Genomes and Genes
Experts and Doctors on neurons in United States
Locale: United States
Publications610 found, 100 shown here
- Zaborszky L. The modular organization of brain systems. Basal forebrain: the last frontier. Prog Brain Res. 2002;136:359-72 pubmed
- Yang Y, Mufson E, Herrup K. Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. J Neurosci. 2003;23:2557-63 pubmed..The implication of the findings for human clinical trials is discussed. ..
- Faherty C, Raviie Shepherd K, Herasimtschuk A, Smeyne R. Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism. Brain Res Mol Brain Res. 2005;134:170-9 pubmed..This non-pharmacological approach presents significant implications for the prevention and/or treatment of PD...
- Kisby G, Olivas A, Standley M, Lu X, Pattee P, O Malley J, et al. Genotoxicants target distinct molecular networks in neonatal neurons. Environ Health Perspect. 2006;114:1703-12 pubmed..Exposure of the brain to environmental agents during critical periods of neuronal development is considered a key factor underlying many neurologic disorders...
- Ren K, Thinschmidt J, Liu J, Ai L, Papke R, King M, et al. alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation. Neuroscience. 2007;145:314-22 pubmed
- Rankin C, Sun Q, Gamblin T. Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures. Neurobiol Dis. 2008;31:368-77 pubmed publisher..We conclude that the phosphorylation of tau by GSK-3beta either prior to or following polymerization promotes polymer/polymer interactions that result in stable clusters of tau filaments. ..
- Wu C, Chang A, Smith M, Won R, Yin X, Staugaitis S, et al. Beta4 tubulin identifies a primitive cell source for oligodendrocytes in the mammalian brain. J Neurosci. 2009;29:7649-57 pubmed publisher..We propose that betaT4 cells are an endogenous cell source that can be recruited to promote neural repair in the adult telencephalon. ..
- Liu C, Fraser S, Koos D. Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway. J Comp Neurol. 2009;516:36-48 pubmed publisher..This subsystem is well suited to detect a unique set of odors and to mediate behaviors that remained intact in previous olfactory perturbations. ..
- Fei G, RAEHAL K, Liu S, Qu M, Sun X, Wang G, et al. Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse. J Pharmacol Exp Ther. 2010;334:333-40 pubmed publisher..Lubiprostone, which does not directly affect enteric neurons, bypasses the neurogenic constipating effects of morphine by directly opening chloride channels in the mucosal epithelium...
- Dachsel J, Behrouz B, Yue M, Beevers J, Melrose H, Farrer M. A comparative study of Lrrk2 function in primary neuronal cultures. Parkinsonism Relat Disord. 2010;16:650-5 pubmed publisher..The phenotype and assay described provides a means to develop therapeutic agents that modulate the toxic gain-of-function conferred by mutant Lrrk2. ..
- Amir A, Amano T, PARE D. Physiological identification and infralimbic responsiveness of rat intercalated amygdala neurons. J Neurophysiol. 2011;105:3054-66 pubmed publisher..The unique response pattern of ITC cells to infralimbic stimuli can now be used to identify them in fear conditioning experiments. ..
- Schmeichel B, Zemlan F, Berridge C. A selective dopamine reuptake inhibitor improves prefrontal cortex-dependent cognitive function: potential relevance to attention deficit hyperactivity disorder. Neuropharmacology. 2013;64:321-8 pubmed publisher..This article is part of a Special Issue entitled 'Cognitive Enhancers'. ..
- Ramesh G, Santana Gould L, Inglis F, England J, Philipp M. The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from dorsal root ganglia. J Neuroinflammation. 2013;10:88 pubmed publisher..In this model, B. burgdorferi induced an inflammatory response and neuronal apoptosis of DRG. These pathophysiological processes could contribute to peripheral neuropathy in LNB. ..
- Sagare A, Bell R, Zhao Z, Ma Q, Winkler E, Ramanathan A, et al. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2013;4:2932 pubmed publisher..Therefore, pericytes may represent a novel therapeutic target to modify disease progression in AD. ..
- Gascon E, Lynch K, Ruan H, Almeida S, Verheyden J, Seeley W, et al. Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia. Nat Med. 2014;20:1444-51 pubmed publisher..Our results identify a previously undescribed mechanism involving miR-124 and AMPARs in regulating social behavior in FTD and suggest a potential therapeutic avenue. ..
- Zhang H, Chang L, Zhang H, Nie J, Zhang Z, Yang X, et al. Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153. Toxicol Lett. 2017;277:41-53 pubmed publisher..Overall, the findings suggested that calpain-2/p35-p25/Cdk5 pathway was involved in BDE-153-induced neuronal apoptosis, which provides novel insight into the mechanisms of PBDE neurotoxicity. ..
- Albers K, Wright D, Davis B. Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system. J Neurosci. 1994;14:1422-32 pubmed..These results demonstrate that NGF production by the epidermal target tissue controls neuronal survival, and in so doing, establishes the level of innervation. ..
- Banerjee S, Hadjiargyrou M, Patterson P. An antibody to the tetraspan membrane protein CD9 promotes neurite formation in a partially alpha3beta1 integrin-dependent manner. J Neurosci. 1997;17:2756-65 pubmed
- Boston B, Blaydon K, Varnerin J, Cone R. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science. 1997;278:1641-4 pubmed..This result implies that in the AY/a mouse, obesity is independent of leptin action, and resistance to leptin results from desensitization of leptin signaling. ..
- Britton J, Edgar B. Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms. Development. 1998;125:2149-58 pubmed..These results demonstrate a fundamental difference in the control of cell cycle activation and maintenance in these two cell types, and imply the existence of a novel mitogen generated by the larval fat body in response to nutrition. ..
- Bantignies F, Goodman R, Smolik S. Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers. Mol Cell Biol. 2000;20:9317-30 pubmed..Our results thus implicate a second class of chromatin-associated proteins in mediating dCBP function and imply that dCBP might be involved in the regulation of higher-order chromatin structure. ..
- Luo R, An M, Arduini B, Henion P. Specific pan-neural crest expression of zebrafish Crestin throughout embryonic development. Dev Dyn. 2001;220:169-74 pubmed..Expression of crestin is gradually downregulated in overtly differentiated cells. Our results indicate that crestin is a specific pan-neural crest marker throughout zebrafish embryogenesis. ..
- Sarter M, Givens B, Bruno J. The cognitive neuroscience of sustained attention: where top-down meets bottom-up. Brain Res Brain Res Rev. 2001;35:146-60 pubmed
- Johnson M, Jin K, Minami M, Chen D, Simon R. Global ischemia induces expression of acid-sensing ion channel 2a in rat brain. J Cereb Blood Flow Metab. 2001;21:734-40 pubmed..The current results suggest a possible role for ASICs in mediating a cellular response to ischemia. ..
- Panksepp J, Huber R. Chronic alterations in serotonin function: dynamic neurochemical properties in agonistic behavior of the crayfish, Orconectes rusticus. J Neurobiol. 2002;50:276-90 pubmed..Moreover, the apparent presence of powerful compensatory mechanisms indicates our need to adopt an increasingly dynamic view of the serotonergic bases of behavior like crayfish aggression. ..
- Sayin U, Rutecki P. Group I metabotropic glutamate receptor activation produces prolonged epileptiform neuronal synchronization and alters evoked population responses in the hippocampus. Epilepsy Res. 2003;53:186-95 pubmed
- Li W, Marquez B, Okino T, Yokokawa F, Shioiri T, Gerwick W, et al. Characterization of the preferred stereochemistry for the neuropharmacologic actions of antillatoxin. J Nat Prod. 2004;67:559-68 pubmed..The decreased potency of the three non-naturally occurring antillatoxin stereoisomers is certainly a result of their dramatically altered overall molecular topologies. ..
- Bugarith K, Dinh T, Li A, Speth R, Ritter S. Basomedial hypothalamic injections of neuropeptide Y conjugated to saporin selectively disrupt hypothalamic controls of food intake. Endocrinology. 2005;146:1179-91 pubmed..Thus, NPY-SAP destroyed NPY receptor-expressing neurons in the ARC and selectively disrupted controls of feeding dependent on those neurons but did not disrupt peptidergic or metabolic controls dependent upon circuitry outside the BMH. ..
- Zhang Z, Ottens A, Sadasivan S, Kobeissy F, Fang T, Hayes R, et al. Calpain-mediated collapsin response mediator protein-1, -2, and -4 proteolysis after neurotoxic and traumatic brain injury. J Neurotrauma. 2007;24:460-72 pubmed..It is possible that the calpain-mediated truncation of CRMPs following TBI may be an inhibiting factor for post-injury neurite regeneration. ..
- Baskerville K, Kent C, Personett D, Lai W, Park P, Coleman P, et al. Aging elevates metabolic gene expression in brain cholinergic neurons. Neurobiol Aging. 2008;29:1874-93 pubmed..The results suggest that aging elicits elevates metabolic activity in cholinergic populations and that this occurs to a much greater degree in the BF group than in the BS group. ..
- Montgomery E. Subthalamic nucleus neuronal activity in Parkinson's disease and epilepsy subjects. Parkinsonism Relat Disord. 2008;14:120-5 pubmed..These and similar findings call into question theories that posit increased STN activity is causal to parkinsonism. ..
- Maher P. Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism. Biochem Pharmacol. 2008;75:1994-2006 pubmed publisher..These data suggest that low concentrations of proteasome inhibitors induce a moderate level of mitochondrial oxidative stress which results in the activation of neuroprotective pathways. ..
- Norris C, Blalock E, Chen K, Porter N, Thibault O, Kraner S, et al. Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging. Neurobiol Aging. 2010;31:328-38 pubmed publisher..Thus, these studies point to altered CN function as a novel and potentially key factor in aging-dependent neuronal Ca(2+) dysregulation. ..
- Streit W, Miller K, Lopes K, Njie E. Microglial degeneration in the aging brain--bad news for neurons?. Front Biosci. 2008;13:3423-38 pubmed
- Bilousova T, Dansie L, Ngo M, Aye J, Charles J, Ethell D, et al. Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model. J Med Genet. 2009;46:94-102 pubmed publisher..These findings establish minocycline as a promising therapeutic for the treatment of fragile X mental retardation. ..
- Tank A, Xu L, Chen X, Radcliffe P, Sterling C. Post-transcriptional regulation of tyrosine hydroxylase expression in adrenal medulla and brain. Ann N Y Acad Sci. 2008;1148:238-48 pubmed publisher..A hypothetical cellular model describing this post-transcriptional regulation is proposed...
- Scharfman H, McCloskey D. Postnatal neurogenesis as a therapeutic target in temporal lobe epilepsy. Epilepsy Res. 2009;85:150-61 pubmed publisher..Although difficult, a number of approaches are possible, and technical advances suggest that there are more on the horizon. ..
- Deshpande A, Dombrowski S, Leichliter A, Krajcir N, Zingales N, Inoue M, et al. Dissociation between vascular endothelial growth factor receptor-2 and blood vessel density in the caudate nucleus after chronic hydrocephalus. J Cereb Blood Flow Metab. 2009;29:1806-15 pubmed publisher..These observed findings suggest that destructive forces may outweigh angiogenic forces and possibly show a disassociation between VEGFR-2 and BV expressions. ..
- Ross B, Tran T, Bhattacharya P, Watterson D, Sailasuta N. Application of NMR spectroscopy in medicinal chemistry and drug discovery. Curr Top Med Chem. 2011;11:93-114 pubmed..Finally, recognizing that a known feature of MR is the lack of sensitivity, we describe new efforts to harness hyperpolarization, with its 50,000 signal amplification, to conventional MRS. ..
- Raisinghani M, Zhong L, Jeffry J, Bishnoi M, Pabbidi R, Pimentel F, et al. Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception. Am J Physiol Cell Physiol. 2011;301:C587-600 pubmed publisher..In conclusion, the characteristics of TRPA1 we have delineated suggest that it might play a unique role in nociception. ..
- Viader A, Ogasawara D, Joslyn C, Sanchez Alavez M, Mori S, Nguyen W, et al. A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation. elife. 2016;5:e12345 pubmed publisher..Mapping the cellular distribution of metabolic enzymes thus identifies pathways for regulating specialized inflammatory responses in the brain while avoiding global alterations in CNS function. ..
- Wang H, Yuan G, Prabhakar N, Boswell M, Katz D. Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling. J Neurochem. 2006;96:694-705 pubmed..These data indicate that oxidative stress can stimulate BDNF release through an autocrine or paracrine loop that requires dopamine receptor activation. ..
- Jiang Q, Yan Z, Feng J. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J Neurosci. 2006;26:4318-28 pubmed..These findings may offer a novel neuroprotective approach against rotenone-induced parkinsonism. ..
- Chen G, Ke Z, Xu M, Liao M, Wang X, Qi Y, et al. Autophagy is a protective response to ethanol neurotoxicity. Autophagy. 2012;8:1577-89 pubmed publisher..Taken together, the results suggest that autophagy activation is a neuroprotective response to alleviate ethanol toxicity. Ethanol modulation of autophagic activity may be mediated by the MTOR pathway. ..
- Fliegner K, Ching G, Liem R. The predicted amino acid sequence of alpha-internexin is that of a novel neuronal intermediate filament protein. EMBO J. 1990;9:749-55 pubmed
- Barmack N, Fredette B, Mugnaini E. Parasolitary nucleus: a source of GABAergic vestibular information to the inferior olive of rat and rabbit. J Comp Neurol. 1998;392:352-72 pubmed
- Wilson W, Walton J. Background noise improves gap detection in tonically inhibited inferior colliculus neurons. J Neurophysiol. 2002;87:240-9 pubmed..Improved feature detection in background noise resulting from inhibitory adaptation would seem an efficient neural mechanism and one that might be generally useful in other signal detection tasks...
- Prendergast M, Rogers D, Mulholland P, Littleton J, Wilkins L, Self R, et al. Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor. Brain Res. 2002;954:300-7 pubmed..These data suggest that the neurotoxic effects of HIV-1 Tat are mediated, in part, by direct interactions with a polyamine-sensitive site on the NMDAr that positively modulates the function of this receptor. ..
- Neubert M, Kincaid W, Heinricher M. Nociceptive facilitating neurons in the rostral ventromedial medulla. Pain. 2004;110:158-65 pubmed..Activation of on-cells likely contributes to enhanced sensitivity to noxious stimulation or reduced sensitivity to analgesic drugs in a variety of conditions. ..
- Teng Q, Tanase D, Tanase D, Liu J, Garrity Moses M, Baker K, et al. Adenoviral clostridial light chain gene-based synaptic inhibition through neuronal synaptobrevin elimination. Gene Ther. 2005;12:108-19 pubmed
- Obara Y, Labudda K, Dillon T, Stork P. PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells. J Cell Sci. 2004;117:6085-94 pubmed..PKA phosphorylation of Src may therefore be required for Rap1 activation in PC12 cells. ..
- Awatramani G, Price G, Trussell L. Modulation of transmitter release by presynaptic resting potential and background calcium levels. Neuron. 2005;48:109-21 pubmed..Together, these studies suggest that control of resting potential is a powerful means for regulating synaptic function at mammalian synapses. ..
- Pozzi S, Rossetti S, Bistulfi G, Sacchi N. RAR-mediated epigenetic control of the cytochrome P450 Cyp26a1 in embryocarcinoma cells. Oncogene. 2006;25:1400-7 pubmed..This study also shows that chromatin inactivity, and consequent transcriptional silencing, can be achieved in the absence of DNA methylation. ..
- Zhang Y, Chen Y, Xie S, Wang L, Lee Y, Chang S, et al. Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain. Mol Endocrinol. 2007;21:908-20 pubmed..The altered Jagged1-Notch signaling in TR4(-/-) forebrain underlies a potential mechanism that contributes to the reduced myelination in the forebrain. ..
- Shen H, Korutla L, Champtiaux N, Toda S, LaLumiere R, Vallone J, et al. NAC1 regulates the recruitment of the proteasome complex into dendritic spines. J Neurosci. 2007;27:8903-13 pubmed..These experiments show that NAC1 modulates the translocation of the UPS from the nucleus into dendritic spines, thereby suggesting a potential missing link in the recruitment of necessary proteolysis machinery for synaptic remodeling. ..
- Young B, Girard B, Parsons R. Neurturin suppresses injury-induced neuronal activating transcription factor 3 expression in cultured guinea pig cardiac ganglia. J Comp Neurol. 2008;508:795-805 pubmed publisher..It is proposed that the loss of target-derived neurturin is a potential mechanism stimulating injury-induced expression of ATF-3 in cardiac neurons. ..
- Barthelery M, Jaishankar A, Salli U, Vrana K. Reptin52 expression during in vitro neural differentiation of human embryonic stem cells. Neurosci Lett. 2009;452:47-51 pubmed..Moreover, expression of two of these proteins (beta-catenin - the end product of the Wnt signaling pathway - and ATF-2) is coordinately regulated with Reptin52. ..
- Viczian A, Solessio E, Lyou Y, Zuber M. Generation of functional eyes from pluripotent cells. PLoS Biol. 2009;7:e1000174 pubmed publisher..These results suggest the fate of pluripotent cells may be purposely altered to generate multipotent retinal progenitor cells, which differentiate into functional retinal cell classes and form a neural circuitry sufficient for vision. ..
- Patel A, Huang T, Krimm R. Lingual and palatal gustatory afferents each depend on both BDNF and NT-4, but the dependence is greater for lingual than palatal afferents. J Comp Neurol. 2010;518:3290-301 pubmed publisher..Thus, gustatory neurons are equally dependent on BDNF and NT-4 expression for survival, regardless of what peripheral target they innervate. However, taste buds are more sensitive to BDNF than NT-4 removal...
- Kerstein P, Jacques Fricke B, Rengifo J, Mogen B, Williams J, Gottlieb P, et al. Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth. J Neurosci. 2013;33:273-85 pubmed publisher..Together our results suggest that Ca(2+) influx through MS TRPC1 on filopodia activates calpain to control growth cone turning during development...
- Nezami B, Mwangi S, Lee J, Jeppsson S, Anitha M, Yarandi S, et al. MicroRNA 375 mediates palmitate-induced enteric neuronal damage and high-fat diet-induced delayed intestinal transit in mice. Gastroenterology. 2014;146:473-83.e3 pubmed publisher..This effect is mediated by Mir375 and is associated with reduced levels of Pdk1. Mir375 might be targeted to increase survival of enteric neurons and gastrointestinal motility. ..
- Martin I, Kim J, Lee B, Kang H, Xu J, Jia H, et al. Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease. Cell. 2014;157:472-485 pubmed publisher..These results reveal a novel mechanism of PD pathogenesis linked to elevated LRRK2 kinase activity and aberrant protein synthesis in vivo. ..
- Darnall R, Schneider R, Tobia C, Commons K. Eliminating medullary 5-HT neurons delays arousal and decreases the respiratory response to repeated episodes of hypoxia in neonatal rat pups. J Appl Physiol (1985). 2016;120:514-25 pubmed publisher..Thus alterations medullary 5-HT mechanisms might contribute to an arousal deficit and contribute to death in SIDS infants. ..
- Mahapatra S, Fan F, Lou X. Tissue-specific dynamin-1 deletion at the calyx of Held decreases short-term depression through a mechanism distinct from vesicle resupply. Proc Natl Acad Sci U S A. 2016;113:E3150-8 pubmed publisher..This role comes into play primarily during brief high-frequency stimulation. ..
- Lee B, Cho G, Norgren R, Junier M, Hill D, Tapia V, et al. TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. Mol Cell Neurosci. 2001;17:107-26 pubmed
- Srinivasan D, Yen J, Joseph D, Friedman W. Cell type-specific interleukin-1beta signaling in the CNS. J Neurosci. 2004;24:6482-8 pubmed
- LeMaster A, Krimm R, Davis B, Noel T, Forbes M, Johnson J, et al. Overexpression of brain-derived neurotrophic factor enhances sensory innervation and selectively increases neuron number. J Neurosci. 1999;19:5919-31 pubmed..These data indicate that skin-derived BDNF does not enhance survival of cutaneous sensory neurons, although it does promote neurite innervation of specific sites and sensory end organs of the skin. ..
- Briski K. Pharmacological manipulation of central nitric oxide/guanylate cyclase activity alters Fos expression by rat hypothalamic vasopressinergic neurons during acute glucose deprivation. J Chem Neuroanat. 1999;17:13-9 pubmed
- Finn L, Zhang M, Chen S, Scott C. Severe type II Gaucher disease with ichthyosis, arthrogryposis and neuronal apoptosis: molecular and pathological analyses. Am J Med Genet. 2000;91:222-6 pubmed..The apoptosis of neuronal cells from the anterior horns and brainstem are a reasonable explanation for the arthrogryposis and neonatal death, respectively. ..
- Vemuri M, Schiller E, Naegele J. Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice. Cell Death Differ. 2001;8:245-55 pubmed..Additional biochemical and immunocytochemical studies indicated that of several DNA repair enzymes investigated, only PARP was increased in scid mice, possibly in response to elevated DNA strand breaks. ..
- Albrecht M, Colegrove S, Hongpaisan J, Pivovarova N, Andrews S, Friel D. Multiple modes of calcium-induced calcium release in sympathetic neurons I: attenuation of endoplasmic reticulum Ca2+ accumulation at low [Ca2+](i) during weak depolarization. J Gen Physiol. 2001;118:83-100 pubmed..These results emphasize the importance of the relative rates of Ca2+ uptake and release in defining ER contributions to depolarization-induced Ca2+ signals. ..
- Chung E, Gu Q, Kwong K, Arden W, Lee L. Comparison of capsaicin-evoked calcium transients between rat nodose and jugular ganglion neurons. Auton Neurosci. 2002;97:83-8 pubmed..Capsaicin at high concentration evoked a greater peak Ca2+ transient in jugular ganglion neurons, despite no difference in the responses to KCl between these two types of ganglion neurons. ..
- Wingrave J, Sribnick E, Wilford G, Matzelle D, Mou J, Ray S, et al. Higher calpastatin levels correlate with resistance to calpain-mediated proteolysis and neuronal apoptosis in juvenile rats after spinal cord injury. J Neurotrauma. 2004;21:1240-54 pubmed..18%), and less neuronal DNA damage, as compared to older rats. These results suggest that increased calpastatin levels found in juvenile rats muted calpain activity and neuronal apoptosis, following spinal cord injury. ..
- Leão R, Kushmerick C, Pinaud R, Renden R, Li G, Taschenberger H, et al. Presynaptic Na+ channels: locus, development, and recovery from inactivation at a high-fidelity synapse. J Neurosci. 2005;25:3724-38 pubmed..We propose that the high density and polarized locus of Na+ channels on a long heminode are critical design features that allow the mature calyx of Held terminal to fire reliably at frequencies near 1 kHz. ..
- Sanchez Pernaute R, Studer L, Ferrari D, Perrier A, Lee H, Vinuela A, et al. Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation. Stem Cells. 2005;23:914-22 pubmed..Optimization of differentiation, cell selection, and cell transfer is required for functional studies of ES-derived DA neurons for future therapeutic applications. ..
- Lucas M, Muller F, Rüdiger R, Henion P, Rohrer H. The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons. Development. 2006;133:4015-24 pubmed..These results demonstrate in vivo an essential and selective function of hand2 for the noradrenergic differentiation of sympathetic neurons, and implicates tfap2a and gata2 as downstream effectors. ..
- Embury J, Charron C, Martynyuk A, Zori A, Liu B, Ali S, et al. PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice. Brain Res. 2007;1127:136-50 pubmed
- Fraser M, Bayazitov I, Zakharenko S, Baker S. Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. Neuroscience. 2008;151:476-88 pubmed..These data suggest that Pten is involved in mechanisms that control development of neuronal and synaptic structures and subsequently synaptic function. ..
- Pacheco Otalora L, Hernandez E, Arshadmansab M, Francisco S, Willis M, Ermolinsky B, et al. Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy. Brain Res. 2008;1200:116-31 pubmed publisher..Moreover, seizure-mediated BK down-regulation may disturb neuronal excitability and presynaptic control at glutamatergic terminals triggering exaggerated glutamate release and seizures. ..
- Saylor A, McGinty J. Amphetamine-induced locomotion and gene expression are altered in BDNF heterozygous mice. Genes Brain Behav. 2008;7:906-14 pubmed publisher..These results indicate that BDNF modifies the locomotor responses of mice to acute amphetamine and differentially regulates amphetamine-induced gene expression. ..
- Granstedt A, Szpara M, Kuhn B, Wang S, Enquist L. Fluorescence-based monitoring of in vivo neural activity using a circuit-tracing pseudorabies virus. PLoS ONE. 2009;4:e6923 pubmed publisher..Our work establishes in vivo investigation of physiological neuronal circuit activity and subsequent effects of infection with single cell resolution...
- Mayer C, Macklin W, Avishai N, Balan K, Wilson C, Miller M. Mutation in the myelin proteolipid protein gene alters BK and SK channel function in the caudal medulla. Respir Physiol Neurobiol. 2009;169:303-14 pubmed publisher..These results provide evidence that Plp mutation specifically alters neuronal excitability through calcium-dependent potassium channels in nTS. ..
- Dickson D, Ahmed Z, Algom A, Tsuboi Y, Josephs K. Neuropathology of variants of progressive supranuclear palsy. Curr Opin Neurol. 2010;23:394-400 pubmed publisher..The basis for anatomical selective vulnerability in PSP and its variants remains to be determined. ..
- Wu G, Lu Z, Kulkarni N, Amin R, Ledeen R. Mice lacking major brain gangliosides develop parkinsonism. Neurochem Res. 2011;36:1706-14 pubmed publisher..These results suggest that perturbation of intracellular mechanisms mediated by intracellular GM1 may be a contributing factor to PD. ..