Genomes and Genes
Experts and Doctors on neurons in United Kingdom
Locale: United Kingdom
Publications290 found, 100 shown here
- O Neill M, Schultz W. Risk prediction error coding in orbitofrontal neurons. J Neurosci. 2013;33:15810-4 pubmed publisher..A group of orbitofrontal neurons displayed a risk signal that tracked the discrepancy between current and predicted risk. Such neuronal signals may be involved in the updating of risk information. ..
- Osborne C, West E, Nolan W, McHale Owen H, Williams A, Bate C. Glimepiride protects neurons against amyloid-Î²-induced synapse damage. Neuropharmacology. 2016;101:225-36 pubmed publisher..Such observations raise the possibility that glimepiride may reduce synapse damage and hence delay the progression of cognitive decline in Alzheimer's disease. ..
- Waterman S. Multiple subtypes of voltage-gated calcium channel mediate transmitter release from parasympathetic neurons in the mouse bladder. J Neurosci. 1996;16:4155-61 pubmed..Furthermore, the release of the two main transmitters in these neurons has differing dependencies on the calcium channel subtypes. ..
- Li Y, Foran P, Lawrence G, Mohammed N, Chan Kwo Chion C, Lisk G, et al. Recombinant forms of tetanus toxin engineered for examining and exploiting neuronal trafficking pathways. J Biol Chem. 2001;276:31394-401 pubmed..Thus, this innocuous mutant may be a useful vehicle, superior to the heavy chain, for drug delivery to central neurons. ..
- Han S, Abraham I, Herbison A. Effect of GABA on GnRH neurons switches from depolarization to hyperpolarization at puberty in the female mouse. Endocrinology. 2002;143:1459-66 pubmed..These findings demonstrate that GnRH neurons display an unusually late postnatal switch in their response to GABA. They also provide the first direct evidence that GABA inhibits the electrical activity of postpubertal GnRH neurons. ..
- Mander P, Borutaite V, Moncada S, Brown G. Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death. J Neurosci Res. 2005;79:208-15 pubmed..Brain inflammation can thus sensitize to hypoxia-induced death, which may be important in pathologies such as stroke, neurodegeneration, and brain aging. ..
- Piper M, Salih S, Weinl C, Holt C, Harris W. Endocytosis-dependent desensitization and protein synthesis-dependent resensitization in retinal growth cone adaptation. Nat Neurosci. 2005;8:179-86 pubmed..These two phases of adaptation allow retinal axons to adjust their range of sensitivity to specific guidance cues. ..
- Khakh B, Fisher J, Nashmi R, Bowser D, Lester H. An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with fluorescence resonance energy transfer and total internal reflection fluorescence microscopy. J Neurosci. 2005;25:6911-20 pubmed..The data provide direct evidence for the close spatial apposition of full-length P2X2 and alpha4beta2 channels within 100 nm of the plasma membrane of living cells. ..
- Wylie S, Chantler P. Myosin IIC: a third molecular motor driving neuronal dynamics. Mol Biol Cell. 2008;19:3956-68 pubmed publisher..This novel combination of properties suggests that myosin IIC must participate in distinctive cellular roles and reinforces our view that closely related motor isoforms drive diverse functions within neuronal cells. ..
- Landles C, Sathasivam K, Weiss A, Woodman B, Moffitt H, Finkbeiner S, et al. Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease. J Biol Chem. 2010;285:8808-23 pubmed publisher..This methodology can be used to validate the inhibition of specific proteases as therapeutic targets for HD by pharmacological or genetic approaches. ..
- Soriano F, Hardingham G. In cortical neurons HDAC3 activity suppresses RD4-dependent SMRT export. PLoS ONE. 2011;6:e21056 pubmed publisher..Furthermore, they underline the fact that HDAC inhibitors can cause reorganization and redistribution of corepressor complexes. ..
- Konopacki F, Jaafari N, Rocca D, Wilkinson K, Chamberlain S, Rubin P, et al. Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis. Proc Natl Acad Sci U S A. 2011;108:19772-7 pubmed publisher..Thus, direct phosphorylation by PKC and GluK2 SUMOylation are intimately linked in regulating the surface expression and function of GluK2-containing KARs. ..
- Ioannidou K, Anderson K, Strachan D, Edgar J, Barnett S. Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS ONE. 2012;7:e30775 pubmed publisher..Moreover, these approaches complement each other with the in vitro approach allowing visualization of an entire internodal length of myelin and the ex vivo approach validating the in vitro data. ..
- Zupanc G, Sîrbulescu R, Ilies I. Radial glia in the cerebellum of adult teleost fish: implications for the guidance of migrating new neurons. Neuroscience. 2012;210:416-30 pubmed publisher..These results suggest the role of radial glia in the guidance of migrating adult-born neurons in the teleostean cerebellum. This function appears to be mediated both by somal translocation and by a glial-guided mode of locomotion. ..
- Cheung G, Cousin M. Adaptor protein complexes 1 and 3 are essential for generation of synaptic vesicles from activity-dependent bulk endosomes. J Neurosci. 2012;32:6014-23 pubmed publisher..Thus, adaptor protein complexes 1 and 3 play an essential dual role in generation of synaptic vesicles during activity-dependent bulk endocytosis. ..
- Craig T, Jaafari N, Petrovic M, Jacobs S, Rubin P, Mellor J, et al. Homeostatic synaptic scaling is regulated by protein SUMOylation. J Biol Chem. 2012;287:22781-8 pubmed publisher..Thus, protein SUMOylation plays an important and previously unsuspected role in synaptic trafficking of AMPARs that underlies homeostatic scaling. ..
- Corrêa S, Hunter C, Palygin O, Wauters S, Martin K, McKenzie C, et al. MSK1 regulates homeostatic and experience-dependent synaptic plasticity. J Neurosci. 2012;32:13039-51 pubmed..MSK1 may thus act as a key homeostat in the activity- and experience-dependent regulation of synaptic strength. ..
- Macgregor D, Leng G. Phasic firing in vasopressin cells: understanding its functional significance through computational models. PLoS Comput Biol. 2012;8:e1002740 pubmed publisher..These findings show large differences in information coding between the populations, and apparent functional advantages of asynchronous phasic firing. ..
- Zeng F, Wind N, McClenaghan C, Verkuyl J, Watson R, Nash M. GPR39 is coupled to TMEM16A in intestinal fibroblast-like cells. PLoS ONE. 2012;7:e47686 pubmed publisher..These data suggest that GPR39 might modulate gut motility via regulating TMEM16A function in FLCs. ..
- Herreros J, Ng T, Schiavo G. Lipid rafts act as specialized domains for tetanus toxin binding and internalization into neurons. Mol Biol Cell. 2001;12:2947-60 pubmed..Our results indicate that TeNT interacts with target cells by binding to lipid rafts and that cholesterol is required for TeNT internalization and/or trafficking in neurons. ..
- Harris W. Temporal coordinates: the genes that fix cell fate with birth order. Dev Cell. 2001;1:313-4 pubmed..In analogy to spatial coordinate genes that specify neuroblasts by position, these sequentially expressed genes can be called "temporal coordinate genes." ..
- Harmar A, Marston H, Shen S, Spratt C, West K, Sheward W, et al. The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Cell. 2002;109:497-508 pubmed..Moreover, the mutants fail to show acute induction of mPer1 and mPer2 by nocturnal illumination. This study highlights the role of intercellular neuropeptidergic signaling in maintenance of circadian function within the SCN. ..
- Azzouz M, Martin Rendon E, Barber R, Mitrophanous K, Carter E, Rohll J, et al. Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat m. J Neurosci. 2002;22:10302-12 pubmed
- Grubb M, Thompson I. Visual response properties in the dorsal lateral geniculate nucleus of mice lacking the beta2 subunit of the nicotinic acetylcholine receptor. J Neurosci. 2004;24:8459-69 pubmed
- Brown M, Jacobs T, Eickholt B, Ferrari G, Teo M, Monfries C, et al. Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. J Neurosci. 2004;24:8994-9004 pubmed..These results indicate that active alpha2-chimaerin Rac GAP, Cdk5/p35, and its substrate CRMP-2, are implicated in the dynamics of growth cone guidance initiated through Sema 3A signaling. ..
- Powell L, zur Lage P, Prentice D, Senthinathan B, Jarman A. The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites. Mol Cell Biol. 2004;24:9517-26 pubmed..While the latter finding shows that enhancer context is also important in defining how proneural proteins interact with these sites, it is clear that differential utilization of DNA binding sites underlies proneural protein specificity. ..
- Chotard C, Leung W, Salecker I. glial cells missing and gcm2 cell autonomously regulate both glial and neuronal development in the visual system of Drosophila. Neuron. 2005;48:237-51 pubmed..Our findings further suggest that gcm genes regulate neurogenesis through collaboration with the Hedgehog-signaling pathway. ..
- Ramanathan S, Combes D, Molinari M, Simmers J, Sillar K. Developmental and regional expression of NADPH-diaphorase/nitric oxide synthase in spinal cord neurons correlates with the emergence of limb motor networks in metamorphosing Xenopus laevis. Eur J Neurosci. 2006;24:1907-22 pubmed..NOS expression reached a peak as the forelimbs emerge then declined. These findings are consistent with a role for nitric oxide (NO) in the developmental transition from undulatory swimming to quadrupedal locomotion. ..
- Blomeley C, Bracci E. Opioidergic interactions between striatal projection neurons. J Neurosci. 2011;31:13346-56 pubmed publisher..Thus, these results reveal a novel, strong opioid-mediated communication between MSNs and provide a new cellular substrate for competitive dynamics in the striatum. ..
- Reeve A, Meagher M, Lax N, Simcox E, Hepplewhite P, Jaros E, et al. The impact of pathogenic mitochondrial DNA mutations on substantia nigra neurons. J Neurosci. 2013;33:10790-801 pubmed publisher..Our finding that the loss of SN neurons was only severe in patients with POLG mutations suggests that acquired mitochondrial defects may be less well tolerated by SN neurons than by inherited ones. ..
- Longden T, Dabertrand F, Hill Eubanks D, Hammack S, Nelson M. Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K+ channel function. Proc Natl Acad Sci U S A. 2014;111:7462-7 pubmed publisher..Because the fidelity of NVC is essential for neuronal health, the impairment characterized here may contribute to the pathophysiology of brain disorders with a stress component. ..
- Nakamura Y, Morrow D, Modgil A, Huyghe D, Deeb T, Lumb M, et al. Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged ?-Aminobutyric Acid Receptor, Type A (GABAA), ?2 Subunit Knock-in Mouse. J Biol Chem. 2016;291:12394-407 pubmed publisher..Thus, our experiments illustrate the complexity of the GABAAR proteome and enhance our understanding of the mechanisms neurons use to construct inhibitory synapses. ..
- Lapiz M, Fulford A, Muchimapura S, Mason R, Parker T, Marsden C. Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission. Neurosci Behav Physiol. 2003;33:13-29 pubmed..A greater understanding of the processes that underlie these changes should improve our knowledge of how environmental events may alter brain development and function, and play a role in the development of neuropsychiatric disorders. ..
- Zhao S, Maxwell S, Jimenez Beristain A, Vives J, Kuehner E, Zhao J, et al. Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons. Eur J Neurosci. 2004;19:1133-40 pubmed..These mice would also provide a useful tool to study DA fate determination from embryo- or adult-derived neural stem cells. ..
- King V, Huang W, Dyall S, Curran O, Priestley J, Michael Titus A. Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J Neurosci. 2006;26:4672-80 pubmed..In contrast, the use of preparations enriched in omega-6 PUFAs after injury could worsen outcome after SCI. ..
- Tarassenko L, Tombs J, Cairns G. On-chip learning with analogue VLSI neural networks. Int J Neural Syst. 1993;4:419-26 pubmed
- Bazenet C, Mota M, Rubin L. The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death. Proc Natl Acad Sci U S A. 1998;95:3984-9 pubmed..Furthermore, Cdc42-induced death was prevented by coexpressing the c-Jun dominant negative FLAGDelta169. Thus, Cdc42 appears to function as an initiator of neuronal cell death by activating a transcriptional pathway regulated by c-Jun. ..
- Zaidi Z, Matthews M. Stimulant-induced exocytosis from neuronal somata, dendrites, and newly formed synaptic nerve terminals in chronically decentralized sympathetic ganglia of the rat. J Comp Neurol. 1999;415:121-43 pubmed..This modulation could be influential in disease-induced decentralization in man...
- Parsons R, Smith M, Williams A, Waring R, Ramsden D. Expression of nicotinamide N-methyltransferase (E.C. 22.214.171.124) in the Parkinsonian brain. J Neuropathol Exp Neurol. 2002;61:111-24 pubmed..This is the first demonstration that patients with PD have higher levels of NNMT activity and protein in brain tissue than those without PD and that NNMT expression is associated with neurons that degenerate in PD. ..
- Boyd G, Low P, Dunlop J, Robertson L, Vardy A, Lambert J, et al. Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins. Mol Cell Neurosci. 2002;21:38-50 pubmed..In support of the existence of homomeric 5-HT3 receptors in vivo, recombinantly expressed 5-HT3A receptors were capable of clustered cell surface expression in cortical neurons. ..
- Bello B, Hirth F, Gould A. A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis. Neuron. 2003;37:209-19 pubmed..These studies identify a mechanism linking the Hox axial patterning system to neural proliferation, and this involves temporal regulation of precursor cell death rather than the cell cycle. ..
- Holmes F, Bacon A, Pope R, Vanderplank P, Kerr N, Sukumaran M, et al. Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior. Proc Natl Acad Sci U S A. 2003;100:6180-5 pubmed..These results support an inhibitory role for galanin in the modulation of nociception both in intact animals and in neuropathic pain states. ..
- Lacey C, Bolam J, Magill P. Novel and distinct operational principles of intralaminar thalamic neurons and their striatal projections. J Neurosci. 2007;27:4374-84 pubmed..This mechanistic diversity likely underpins the transmission of specific and discrete information from intralaminar thalamic nuclei to striatal and cortical targets. ..
- Nijhawan R. Visual prediction: psychophysics and neurophysiology of compensation for time delays. Behav Brain Sci. 2008;31:179-98; discussion 198-239 pubmed publisher..Understanding visual prediction will inform our theories of sensory processes and visual perception, and will impact our notion of visual awareness. ..
- Friocourt G, Kanatani S, Tabata H, Yozu M, Takahashi T, Antypa M, et al. Cell-autonomous roles of ARX in cell proliferation and neuronal migration during corticogenesis. J Neurosci. 2008;28:5794-805 pubmed publisher..However, our data suggest that ARX is not directly involved in GABAergic cell fate specification. Overall, these results identify multiple and distinct cell-autonomous roles for ARX in corticogenesis. ..
- Kanu N, Penicud K, Hristova M, Wong B, Irvine E, Plattner F, et al. The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem. 2010;285:38534-42 pubmed publisher..These results suggest that ATMIN mediates ATM activation by oxidative stress, and thereby ATMIN protects the aging brain by preventing accumulation of DNA damage. ..
- Puddifoot C, Martel M, Soriano F, Camacho A, Vidal Puig A, Wyllie D, et al. PGC-1Î± negatively regulates extrasynaptic NMDAR activity and excitotoxicity. J Neurosci. 2012;32:6995-7000 pubmed publisher..The link between mHtt, PGC-1Î±, and NMDAR activity was also confirmed in rat striatal neurons. Thus, targeting levels of PGC-1Î± expression may help reduce aberrant NMDAR(EX) activity in disorders where PGC-1Î± is underexpressed. ..
- Allen C, Thornton P, Denes A, McColl B, Pierozynski A, Monestier M, et al. Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA. J Immunol. 2012;189:381-92 pubmed publisher..Such mechanisms have important implications for neuroinflammatory disorders, notably in the development of antileukocyte therapies. ..
- Keimpema E, Tortoriello G, Alpar A, Capsoni S, Arisi I, Calvigioni D, et al. Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. Proc Natl Acad Sci U S A. 2013;110:1935-40 pubmed publisher..These data indicate that NGF can orchestrate endocannabinoid signaling to promote cholinergic differentiation and implicate BRCA1 in determining neuronal morphology. ..
- Nowakowski T, Fotaki V, Pollock A, Sun T, Pratt T, Price D. MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brain. Proc Natl Acad Sci U S A. 2013;110:7056-61 pubmed publisher..Acute miR-92b loss of function had opposite effects. These findings indicate that miR-92b limits the production of intermediate cortical progenitors. ..
- Emiliani V, Cohen A, Deisseroth K, HÃ¤usser M. All-Optical Interrogation of Neural Circuits. J Neurosci. 2015;35:13917-26 pubmed publisher..These advances promise to illuminate many fundamental challenges in neuroscience, including transforming our search for the neural code and the links between neural circuit activity and behavior. ..
- Hansen K, Sakamoto K, Aten S, Snider K, Loeser J, Hesse A, et al. Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome. Learn Mem. 2016;23:61-71 pubmed publisher..The dysregulation of miR-132/-212 expression could contribute to signaling mechanisms that are involved in an array of cognitive disorders. ..
- Jenkins S, Weinberg D, Al Shakli A, Fernandes A, Yiu H, Telling N, et al. 'Stealth' nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics. J Control Release. 2016;224:136-145 pubmed publisher..We demonstrate changes in protein coronas around these particles within biological media, and discuss how surface chemistry presentation may affect this process and subsequent cellular interactions. ..
- Vickers D, Moore B, Baer T. Effects of low-pass filtering on the intelligibility of speech in quiet for people with and without dead regions at high frequencies. J Acoust Soc Am. 2001;110:1164-75 pubmed..The results have important implications for the fitting of hearing aids...
- Groot Kormelink P, Broadbent S, Boorman J, Sivilotti L. Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors. J Gen Physiol. 2004;123:697-708 pubmed..Such inaccuracies in concatameric receptor assembly would not have been apparent with a standard functional characterization of the receptor. Extensive validation is needed for tandem-expressed receptors in the nicotinic superfamily. ..
- Tillin N, Jimenez Reyes P, Pain M, Folland J. Neuromuscular performance of explosive power athletes versus untrained individuals. Med Sci Sports Exerc. 2010;42:781-90 pubmed publisher..The differences in voluntary normalized RFD between athletes and controls were explained by agonist muscle neural activation and not by the similar intrinsic contractile properties of the groups. ..
- Ribes V, Balaskas N, Sasai N, Cruz C, Dessaud E, Cayuso J, et al. Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev. 2010;24:1186-200 pubmed publisher..In addition, we provide evidence supporting a common scheme for FP specification by Shh signaling that reconciles mechanisms of FP development in teleosts and amniotes. ..
- Chen Y, Magnani D, Theil T, Pratt T, Price D. Evidence that descending cortical axons are essential for thalamocortical axons to cross the pallial-subpallial boundary in the embryonic forebrain. PLoS ONE. 2012;7:e33105 pubmed publisher..These results support the hypothesis that thalamic axons grow from subpallium to cortex guided by cortical efferents, with stimulation from diffusible cortical growth-promoting factors. ..
- Cuntz H, Mathy A, HÃ¤usser M. A scaling law derived from optimal dendritic wiring. Proc Natl Acad Sci U S A. 2012;109:11014-8 pubmed publisher..Our results imply fundamentally distinct design principles for dendritic arbors compared with vascular, bronchial, and botanical trees. ..
- Varela M, Schnettler E, Caporale M, Murgia C, Barry G, McFarlane M, et al. Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host. PLoS Pathog. 2013;9:e1003133 pubmed publisher..Attenuation of SBV virulence depends on the inability of SBVΔNSs to block IFN synthesis in virus infected cells. In conclusion, this work provides a useful experimental framework to study the biology and pathogenesis of SBV. ..
- Davies S, Turmaine M, Cozens B, Difiglia M, Sharp A, Ross C, et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell. 1997;90:537-48 pubmed..The appearance in transgenic mice of these inclusions, followed by characteristic morphological change within neuronal nuclei, is strikingly similar to nuclear abnormalities observed in biopsy material from HD patients. ..
- Brown T, Hughes A, Piggins H. Gastrin-releasing peptide promotes suprachiasmatic nuclei cellular rhythmicity in the absence of vasoactive intestinal polypeptide-VPAC2 receptor signaling. J Neurosci. 2005;25:11155-64 pubmed..These findings establish that residual electrical oscillations persist in the SCN of Vipr2(-/-) mice and reveal a potential new role for GRP-BB2 signaling within the circadian clock. ..
- Nguyen L, Besson A, Heng J, Schuurmans C, Teboul L, Parras C, et al. p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev. 2006;20:1511-24 pubmed..Thus, p27(Kip1) plays a key role in cortical development, acting as a modular protein that independently regulates and couples multiple cellular pathways contributing to neurogenesis. ..
- Pooler A, McIlhinney R. Lateral diffusion of the GABAB receptor is regulated by the GABAB2 C terminus. J Biol Chem. 2007;282:25349-56 pubmed..Treatment of COS-7 cells with the GABAB receptor agonist baclofen significantly increased its mobile fraction. These data show that the restricted movement of GABAB at the cell surface is regulated by a region within its C terminus. ..
- Gu P, Harwood L, Zhang X, Wylie M, Curry W, Cogliati T. Isolation of retinal progenitor and stem cells from the porcine eye. Mol Vis. 2007;13:1045-57 pubmed
- Delivopoulos E, Murray A, Curtis J. Effects of parylene-C photooxidation on serum-assisted glial and neuronal patterning. J Biomed Mater Res A. 2010;94:47-58 pubmed publisher..c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010. ..
- Tse K, Sun M, Mantovani C, Terenghi G, Downes S, Kingham P. In vitro evaluation of polyester-based scaffolds seeded with adipose derived stem cells for peripheral nerve regeneration. J Biomed Mater Res A. 2010;95:701-8 pubmed publisher..This study suggests polymer scaffolds combined with dADSCs could be a promising therapy for peripheral nerve injuries. ..
- Holgado A, Terry J, Bogacz R. Conditions for the generation of beta oscillations in the subthalamic nucleus-globus pallidus network. J Neurosci. 2010;30:12340-52 pubmed publisher..These conditions describe changes in parameters that are consistent with those expected as a result of the development of Parkinson's disease, and predict manipulations that could inhibit the pathological oscillations. ..
- Magnani D, Hasenpusch Theil K, Jacobs E, Campagnoni A, Price D, Theil T. The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence. J Neurosci. 2010;30:13883-94 pubmed publisher..We conclude that correct Gli3 levels are particularly important for the LGE's growth, patterning, and development of axon guidance capabilities. ..
- Agostini M, Tucci P, Killick R, Candi E, Sayan B, Rivetti di Val Cervo P, et al. Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A. 2011;108:21093-8 pubmed publisher..Notably, the axis TAp73/miR-34a/synaptotagmin-1 is conserved in brains from Alzheimer's patients. These data reinforce a role for TAp73 in neuronal development. ..
- Seoane A, Tinsley C, Brown M. Interfering with Fos expression in rat perirhinal cortex impairs recognition memory. Hippocampus. 2012;22:2101-13 pubmed publisher..Antisense Fos ODN infusion also impaired object-in-place recognition memory. The results demonstrate that Fos is necessary for neuronal mechanisms in PRH cortex essential to recognition memory. ..
- Baseer N, Polgár E, Watanabe M, Furuta T, Kaneko T, Todd A. Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons. J Neurosci. 2012;32:11854-63 pubmed publisher..It is therefore likely that polysynaptic inputs to the lamina III projection neurons are recruited during the development of chronic pain states. ..
- Bernard V, Somogyi P, Bolam J. Cellular, subcellular, and subsynaptic distribution of AMPA-type glutamate receptor subunits in the neostriatum of the rat. J Neurosci. 1997;17:819-33 pubmed
- Komiyama N, Watabe A, Carlisle H, Porter K, Charlesworth P, Monti J, et al. SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci. 2002;22:9721-32 pubmed..A comparison of SynGAP and PSD-95 mutants suggests that PSD-95 couples NMDARs to multiple downstream signaling pathways with very different roles in LTP and learning. ..
- Jacob T, Bogdanov Y, Magnus C, Saliba R, Kittler J, Haydon P, et al. Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors. J Neurosci. 2005;25:10469-78 pubmed
- Allen T, Abogadie F, Brown D. Simultaneous release of glutamate and acetylcholine from single magnocellular "cholinergic" basal forebrain neurons. J Neurosci. 2006;26:1588-95 pubmed..This has implications for BF neuron function and for the use of cholinesterase inhibitors in Alzheimer's disease. ..
- James A, Conway A, Morris B. Regulation of the neuronal proteasome by Zif268 (Egr1). J Neurosci. 2006;26:1624-34 pubmed
- Billups D, Billups B, Challiss R, Nahorski S. Modulation of Gq-protein-coupled inositol trisphosphate and Ca2+ signaling by the membrane potential. J Neurosci. 2006;26:9983-95 pubmed
- Mena Segovia J, Micklem B, Nair Roberts R, Ungless M, Bolam J. GABAergic neuron distribution in the pedunculopontine nucleus defines functional subterritories. J Comp Neurol. 2009;515:397-408 pubmed publisher..Our data suggest that the PPN is neurochemically segregated, and such differences define functional territories. ..
- Mitchell J, Paul P, Chen H, Morris A, Payling M, Falchi M, et al. Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase. Proc Natl Acad Sci U S A. 2010;107:7556-61 pubmed publisher..DAO controls the level of D-serine, which accumulates in the spinal cord in cases of sporadic ALS and in a mouse model of ALS, indicating that this abnormality may represent a fundamental component of ALS pathogenesis. ..
- Ossola B, Zhao C, Compston A, Pluchino S, Franklin R, Spillantini M. Neuronal expression of pathological tau accelerates oligodendrocyte progenitor cell differentiation. Glia. 2016;64:457-71 pubmed publisher..Our data suggest the intriguing concept that damaged axons may signal to OPCs and promote their differentiation in the attempt at rescue by remyelination. ..
- LeBeau F, Malmierca M, Rees A. Iontophoresis in vivo demonstrates a key role for GABA(A) and glycinergic inhibition in shaping frequency response areas in the inferior colliculus of guinea pig. J Neurosci. 2001;21:7303-12 pubmed
- Poulet J, Hedwig B. Corollary discharge inhibition of ascending auditory neurons in the stridulating cricket. J Neurosci. 2003;23:4717-25 pubmed..5 kHz stimuli. The hyperpolarization desensitized the response of AN1 to subsequent quieter stimuli. Therefore, the corollary discharge will reduce desensitization by suppressing the response of AN1 to self-generated sounds. ..
- Burdakov D, Jensen L, Alexopoulos H, Williams R, Fearon I, O Kelly I, et al. Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron. 2006;50:711-22 pubmed..These results reveal an unexpected energy-sensing pathway in neurons that regulate states of consciousness and energy balance. ..