Genomes and Genes
Experts and Doctors on neuronal cell adhesion molecules in Germany
Topic: neuronal cell adhesion molecules
- Vishnu S, Hertenstein A, Betschinger J, Knoblich J, Gert de Couet H, Fischbach K. The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila. Dev Biol. 2006;289:296-307 pubmed..Using genetic, cell biological, and biochemical approaches, we show that the interaction of Rst with X11Lalpha is of biological significance. The proteins interact, for example, in the context of cell sorting in the pupal retina. ..
- Andersen O, Benhayon D, Curran T, Willnow T. Differential binding of ligands to the apolipoprotein E receptor 2. Biochemistry. 2003;42:9355-64 pubmed..This finding indicates that aggregation of apoER2 by multivalent ligands such as Reelin may be the structural basis for signal transduction. ..
- Werno C, Menrad H, Weigert A, Dehne N, Goerdt S, Schledzewski K, et al. Knockout of HIF-1? in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses. Carcinogenesis. 2010;31:1863-72 pubmed publisher..Our data suggest that HIF-1?-deficient M?s develop a more prominent TAM marker profile accompanied by reduced cytotoxicity, whereas HIF-1 seems indispensable for the angiogenesis-promoting properties of TAMs. ..
- Haas C, Dudeck O, Kirsch M, Huszka C, Kann G, Pollak S, et al. Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. J Neurosci. 2002;22:5797-802 pubmed..These results suggest that reelin is required for normal neuronal lamination in humans, and that deficient reelin expression may be involved in migration defects associated with temporal lobe epilepsy. ..
- Banovic D, Khorramshahi O, Owald D, Wichmann C, Riedt T, Fouquet W, et al. Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions. Neuron. 2010;66:724-38 pubmed publisher..Instead, other signaling components are likely involved in DNlg1 transsynaptic functions, with essential interactions organized by the DNlg1 extracellular domain but also by the cytoplasmic domain. ..
- Freigang J, Proba K, Leder L, Diederichs K, Sonderegger P, Welte W. The crystal structure of the ligand binding module of axonin-1/TAG-1 suggests a zipper mechanism for neural cell adhesion. Cell. 2000;101:425-33 pubmed..In accordance with this model, mutations in a loop critical for the formation of the zipper resulted in the loss of the homophilic binding capacity of axonin-1. ..
- Irintchev A, Zeschnigk M, Starzinski Powitz A, Wernig A. Expression pattern of M-cadherin in normal, denervated, and regenerating mouse muscles. Dev Dyn. 1994;199:326-37 pubmed..These observations are in line with the idea that Mcad plays a crucial role in myogenesis. In intact muscle, Mcad might function as a molecular link between satellite cell and muscle fiber. ..
- Reiter C, Schimansky T, Nie Z, Fischbach K. Reorganization of membrane contacts prior to apoptosis in the Drosophila retina: the role of the IrreC-rst protein. Development. 1996;122:1931-40 pubmed..This reorganisation is a prerequisite for the identification of death candidates. Irregular chiasmC-roughest function in retinal development demonstrates the importance of specific cell contacts for assignment of the apoptotic fate. ..
- Strünkelnberg M, Bonengel B, Moda L, Hertenstein A, de Couet H, Ramos R, et al. rst and its paralogue kirre act redundantly during embryonic muscle development in Drosophila. Development. 2001;128:4229-39 pubmed..This defect can be rescued by one copy of either gene. Moreover, Rst, like Kirre is a myoblast attractant. ..
- Kzhyshkowska J, Gratchev A, Schmuttermaier C, Brundiers H, Krusell L, Mamidi S, et al. Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosis. J Immunol. 2008;180:3028-37 pubmed..5 microg/ml in fetal circulation. We propose that stabilin-1-positive macrophages determine the difference in PL levels between maternal and fetal circulation. ..
- Stolt P, Bock H. Modulation of lipoprotein receptor functions by intracellular adaptor proteins. Cell Signal. 2006;18:1560-71 pubmed
- Ramos R, Igloi G, Lichte B, Baumann U, Maier D, Schneider T, et al. The irregular chiasm C-roughest locus of Drosophila, which affects axonal projections and programmed cell death, encodes a novel immunoglobulin-like protein. Genes Dev. 1993;7:2533-47 pubmed..Both known irreC alleles reduce the level of transcription, whereas the roughestCT mutation disrupts the intracellular domain of the protein. ..
- Ankerhold R, Leppert C, Bastmeyer M, Stuermer C. E587 antigen is upregulated by goldfish oligodendrocytes after optic nerve lesion and supports retinal axon regeneration. Glia. 1998;23:257-70 pubmed
- Horst D, Kriegl L, Engel J, Kirchner T, Jung A. Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer. Cancer Invest. 2009;27:844-50 pubmed publisher..We show that CD133 is the best sole marker to predict low patient survival, while the combined analysis of all three markers may be superior in identification of low-, intermediate-, and high-risk cases of colorectal cancer. ..
- Wittenmayer N, Körber C, Liu H, Kremer T, Varoqueaux F, Chapman E, et al. Postsynaptic Neuroligin1 regulates presynaptic maturation. Proc Natl Acad Sci U S A. 2009;106:13564-9 pubmed publisher..These data show that induction of presynaptic terminal assembly and maturation involve mechanistically distinct actions of Neuroligins, and that Neuroligin1 is essential for presynaptic terminal maturation. ..
- Hummel T, Schimmelpfeng K, Klämbt C. Commissure formation in the embryonic CNS of Drosophila. Development. 1999;126:771-9 pubmed..The results lead to a detailed model relating different cellular functions to axonal patterning at the midline. ..
- Forster E, Tielsch A, Saum B, Weiss K, Johanssen C, Graus Porta D, et al. Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus. Proc Natl Acad Sci U S A. 2002;99:13178-83 pubmed..Moreover, recombinant Reelin induced branching of glial processes in vitro. Our data suggest that Reelin affects glial differentiation via Disabled 1 and beta(1)-class integrin-dependent signaling pathways. ..
- Hartfuss E, Forster E, Bock H, Hack M, Leprince P, Luque J, et al. Reelin signaling directly affects radial glia morphology and biochemical maturation. Development. 2003;130:4597-609 pubmed..Taken together, these results unravel a novel role of reelin signaling to radial glial cells that is crucial for the regulation of their Blbp content and characteristic morphology in a region-specific manner. ..
- Volkmer H, Zacharias U, Nörenberg U, Rathjen F. Dissection of complex molecular interactions of neurofascin with axonin-1, F11, and tenascin-R, which promote attachment and neurite formation of tectal cells. J Cell Biol. 1998;142:1083-93 pubmed..In conclusion, these investigations indicate that the molecular interactions of neurofascin are regulated at different levels, including alternative splicing and by the presence of interacting proteins. ..
- Derfuss T, Parikh K, Velhin S, Braun M, Mathey E, Krumbholz M, et al. Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proc Natl Acad Sci U S A. 2009;106:8302-7 pubmed publisher..This study identifies contactin-2 as an autoantigen targeted by T cells and autoantibodies in MS. Our findings suggest that a contactin-2-specific T-cell response contributes to the development of gray matter pathology. ..
- Schapitz I, Behrend B, Pechmann Y, Lappe Siefke C, Kneussel S, Wallace K, et al. Neuroligin 1 is dynamically exchanged at postsynaptic sites. J Neurosci. 2010;30:12733-44 pubmed publisher..Our data suggest the concept that synaptic plasticity regulates neuroligin turnover through active cytoskeleton transport...
- Santos J, VÃ¶mel M, Struck R, Homberg U, NÃ¤ssel D, Wegener C. Neuroarchitecture of peptidergic systems in the larval ventral ganglion of Drosophila melanogaster. PLoS ONE. 2007;2:e695 pubmed..The data can further be useful to identify colocalized transmitters and receptors, and develop peptidergic neurons as new landmarks. ..
- Schweitzer J, Gimnopoulos D, Lieberoth B, Pogoda H, Feldner J, Ebert A, et al. Contactin1a expression is associated with oligodendrocyte differentiation and axonal regeneration in the central nervous system of zebrafish. Mol Cell Neurosci. 2007;35:194-207 pubmed..These complex regulation patterns suggest roles for Cntn1a in myelinating cells and neurons particularly in successful CNS regeneration. ..
- Maertens B, Hopkins D, Franzke C, Keene D, Bruckner Tuderman L, Greenspan D, et al. Cleavage and oligomerization of gliomedin, a transmembrane collagen required for node of ranvier formation. J Biol Chem. 2007;282:10647-59 pubmed..Interestingly, the later cleavage induces formation of higher order, insoluble molecular aggregates that may play important roles in Na(+)-channel clustering. ..
- Schneider T, Reiter C, Eule E, Bader B, Lichte B, Nie Z, et al. Restricted expression of the irreC-rst protein is required for normal axonal projections of columnar visual neurons. Neuron. 1995;15:259-71 pubmed..Epigenesis of the phenotypes can be explained partially on the bases of homophilic irreC-rst interactions. ..
- Schwab M, Bartholomae A, Heimrich B, Feldmeyer D, Druffel Augustin S, Goebbels S, et al. Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. J Neurosci. 2000;20:3714-24 pubmed..The primary developmental arrest appears to be restricted to granule cells in which an autoregulatory system involving all three neuronal bHLH genes has failed. ..
- Zacharias U, Nörenberg U, Rathjen F. Functional interactions of the immunoglobulin superfamily member F11 are differentially regulated by the extracellular matrix proteins tenascin-R and tenascin-C. J Biol Chem. 1999;274:24357-65 pubmed..These results suggest that the molecular interactions of F11 might be regulated by the presence of tenascin-R and tenascin-C. ..
- Sibbe M, Forster E, Basak O, Taylor V, Frotscher M. Reelin and Notch1 cooperate in the development of the dentate gyrus. J Neurosci. 2009;29:8578-85 pubmed publisher..These results suggest that Reelin enhances Notch1 signaling, thereby contributing to the formation of the radial glial scaffold and the normal development of the dentate gyrus. ..
- Str nkelnberg M, de Couet H, Hertenstein A, Fischbach K. Interspecies comparison of a gene pair with partially redundant function: the rst and kirre genes in D. virilis and D. melanogaster. J Mol Evol. 2003;56:187-97 pubmed publisher..These findings are discussed in the light of general evolutionary mechanisms...
- Schledzewski K, Falkowski M, Moldenhauer G, Metharom P, Kzhyshkowska J, Ganss R, et al. Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangi. J Pathol. 2006;209:67-77 pubmed..This improved approach will help to clarify the prognostic significance of lymphangiogenesis in malignant tumours...
- Marg A, Sirim P, Spaltmann F, Plagge A, Kauselmann G, Buck F, et al. Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP. J Cell Biol. 1999;145:865-76 pubmed..Our data suggest that neurotractin participates in the regulation of neurite outgrowth in the developing brain. ..
- Frotscher M, Haas C, Forster E. Reelin controls granule cell migration in the dentate gyrus by acting on the radial glial scaffold. Cereb Cortex. 2003;13:634-40 pubmed..These findings show that the Reelin signaling pathway is essential for the correct positioning of human hippocampal neurons and that a Reelin deficiency is involved in the pathological changes associated with epilepsy. ..
- Senner V, Schmidtpeter S, Braune S, Püttmann S, Thanos S, Bartsch U, et al. AMOG/beta2 and glioma invasion: does loss of AMOG make tumour cells run amok?. Neuropathol Appl Neurobiol. 2003;29:370-7 pubmed..We conclude that increasing loss of AMOG/beta2 during malignant progression parallels and may underlie the extensive invasion pattern of malignant gliomas. ..
- Silies M, Klämbt C. APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS. Nat Neurosci. 2010;13:1357-64 pubmed publisher..This represents a simple mechanism by which a subcellular gradient of adhesiveness can coordinate glial migration with axonal growth...
- Stork T, Thomas S, Rodrigues F, Silies M, Naffin E, Wenderdel S, et al. Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to Wrapper. Development. 2009;136:1251-61 pubmed publisher..We conclude that Neurexin IV can mediate different adhesive cell-cell contacts depending on the isoforms expressed and the context of its interaction partners. ..
- Chai X, Forster E, Zhao S, Bock H, Frotscher M. Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3. J Neurosci. 2009;29:288-99 pubmed publisher..These novel findings suggest that Reelin-induced stabilization of neuronal processes anchors them to the marginal zone which appears to be required for the directional migration process. ..
- Kzhyshkowska J, Workman G, Cardo Vila M, Arap W, Pasqualini R, Gratchev A, et al. Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC. J Immunol. 2006;176:5825-32 pubmed..We propose that alternatively activated macrophages coordinate extracellular matrix remodeling, angiogenesis, and tumor progression via stabilin-1-mediated endocytosis of SPARC and thereby regulate its extracellular concentration. ..
- Kilb W, Hartmann D, Saftig P, Luhmann H. Altered morphological and electrophysiological properties of Cajal-Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout mice. Eur J Neurosci. 2004;20:2749-56 pubmed..The depolarized membrane potential observed in PS1-/- CRcs may increase the susceptibility to neuronal death, thus facilitating the premature loss of CRcs in PS1-/- mice. ..
- Ulzheimer J, Peles E, Levinson S, Martini R. Altered expression of ion channel isoforms at the node of Ranvier in P0-deficient myelin mutants. Mol Cell Neurosci. 2004;25:83-94 pubmed..Thus, deficiency of P0 leads to dysregulation of nodal VGSC isoforms and to altered localization of paranodal and juxtaparanodal components of the nodal complex. ..
- Stoykova A, Hatano O, Gruss P, Gotz M. Increase in reelin-positive cells in the marginal zone of Pax6 mutant mouse cortex. Cereb Cortex. 2003;13:560-71 pubmed..Taken together, these experiments further elucidate how patterning of the forebrain by the transcription factor Pax6 regulates the specification of distinct neuronal subtypes in the cortical MZ. ..
- Gebhardt C, Del Turco D, Drakew A, Tielsch A, Herz J, Frotscher M, et al. Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice. J Comp Neurol. 2002;445:278-92 pubmed..These data provide further evidence for a role of granule cells in the laminar termination of commissural/associational afferents to the fascia dentata. ..
- Politz O, Gratchev A, McCourt P, Schledzewski K, Guillot P, Johansson S, et al. Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochem J. 2002;362:155-64 pubmed
- Cremer H, Lange R, Christoph A, Plomann M, Vopper G, Roes J, et al. Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature. 1994;367:455-9 pubmed..The animals showed deficits in spatial learning when tested in the Morris water maze, whereas activity and motor abilities appeared normal. ..