Genomes and Genes
Experts and Doctors on nervous system diseases in United States
Locale: United States
Topic: nervous system diseases
Publications114 found, 100 shown here
- Khaing Z, Schmidt C. Advances in natural biomaterials for nerve tissue repair. Neurosci Lett. 2012;519:103-14 pubmed publisher..In addition, newly developed advanced fabrication techniques to further develop the next generation natural biomaterials-based therapeutic devices are discussed. ..
- Johnson R, Mitchell G. Common mechanisms of compensatory respiratory plasticity in spinal neurological disorders. Respir Physiol Neurobiol. 2013;189:419-28 pubmed publisher..Through this contrast, we hope to understand the multilayered strategies used to "fight" for adequate breathing in the face of mounting pathology. ..
- Farooqui A, Ong W, Horrocks L. Plasmalogens, docosahexaenoic acid and neurological disorders. Adv Exp Med Biol. 2003;544:335-54 pubmed
- Yasuhara T, Hara K, Maki M, Masuda T, Sanberg C, Sanberg P, et al. Dietary supplementation exerts neuroprotective effects in ischemic stroke model. Rejuvenation Res. 2008;11:201-14 pubmed publisher..These data demonstrate the remarkable neuroprotective effects of NT-020 when given prior to stroke, possibly acting via its neurogenic potential. ..
- Stump D, Beck M, Radovsky A, Garman R, Freshwater L, Sheets L, et al. Developmental neurotoxicity study of dietary bisphenol A in Sprague-Dawley rats. Toxicol Sci. 2010;115:167-82 pubmed publisher..There was no evidence that BPA is a developmental neurotoxicant in rats, and the NOAEL for developmental neurotoxicity was 2250 ppm, the highest dose tested (164 and 410 mg/kg/day during gestation and lactation, respectively). ..
- Sakamoto K, Karelina K, Obrietan K. CREB: a multifaceted regulator of neuronal plasticity and protection. J Neurochem. 2011;116:1-9 pubmed publisher..We also discuss work showing that CREB is a critical component of the neuroprotective transcriptional network, and data indicating that CREB dysregulation contributes to an array of neuropathological conditions. ..
- Kelly M, Lenke L, Godzik J, Pellisé F, Shaffrey C, Smith J, et al. Retrospective analysis underestimates neurological deficits in complex spinal deformity surgery: a Scoli-RISK-1 Study. J Neurosurg Spine. 2017;27:68-73 pubmed publisher..These findings validate concerns regarding retrospective cohort studies and confirm the need for and value of carefully designed prospective, observational cohort studies in ASD. ..
- OCHOA J, Campero M, Serra J, Bostock H. Hyperexcitable polymodal and insensitive nociceptors in painful human neuropathy. Muscle Nerve. 2005;32:459-72 pubmed..This similarity, and the striking heat dependence of the spontaneous pain, suggest that a common feature may be altered expression or modulation of vanilloid 1 receptor, provoking abnormal nociceptor discharges. ..
- Pallotto E, Kilbride H. Perinatal outcome and later implications of intrauterine growth restriction. Clin Obstet Gynecol. 2006;49:257-69 pubmed..Morbidities associated with preterm delivery appear to be additive to those associated with fetal growth restriction so IUGR, preterm infants may be at great risk for poor neurodevelopmental outcome. ..
- Nozaki K, Silver R, Stickler D, Abou Fayssal N, Giglio P, Kamen D, et al. Neurological deficits during treatment with tumor necrosis factor-alpha antagonists. Am J Med Sci. 2011;342:352-5 pubmed publisher..Determining if the relationship between the neurological deficits and TNF-? antagonist therapy is causal can be challenging and can impact patient care. ..
- Pollock J. Transient neurologic symptoms: etiology, risk factors, and management. Reg Anesth Pain Med. 2002;27:581-6 pubmed
- Koide M, Nystoriak M, Krishnamoorthy G, O Connor K, Bonev A, Nelson M, et al. Reduced Ca2+ spark activity after subarachnoid hemorrhage disables BK channel control of cerebral artery tone. J Cereb Blood Flow Metab. 2011;31:3-16 pubmed publisher..This phenomenon may contribute to decreased cerebral blood flow and poor outcome after aneurysmal SAH. ..
- McKay W. Neurophysiological characterization of the 'new anatomy' and motor control that results from neurological injury or disease. Clin Neurol Neurosurg. 2012;114:447-54 pubmed publisher..Measured through multiple-muscle recordings of selected motor-task performance, these domains can be useful in quantifying the severity of CNS damage and changes achieved through recovery or treatment. ..
- Spencer P, Kisby G, Ludolph A. Slow toxins, biologic markers, and long-latency neurodegenerative disease in the western Pacific region. Neurology. 1991;41:62-6; discussion 66-8 pubmed..This paper explores the possible relationship between tumorigenesis and long-latency neurotoxicity, and discusses possible biologic markers of cycad exposure and subclinical neurodegenerative disease...
- Tani M, Fuentes M, Peterson J, Trapp B, Durham S, Loy J, et al. Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes. J Clin Invest. 1996;98:529-39 pubmed..Late-onset neurological symptoms in MBP-N51/KC mice may indicate unanticipated consequences of CNS chemokine expression. ..
- Berger J, Fannin M. The "bedsheet" Babinski. South Med J. 2002;95:1178-9 pubmed..Although typically elicited by stroking the plantar surface of the foot with a firm object, other means of obtaining the response have been described...
- Judson M. Sarcoidosis: clinical presentation, diagnosis, and approach to treatment. Am J Med Sci. 2008;335:26-33 pubmed publisher..Sarcoidosis may remit spontaneously or remain stable. Therefore, therapy is not mandated for the disease. This report reviews the clinical presentation, diagnostic approach, and treatment of sarcoidosis. ..
- Westmark C, Westmark P, Malter J. Soy-based diet exacerbates seizures in mouse models of neurological disease. J Alzheimers Dis. 2013;33:797-805 pubmed publisher..Thus, the soy isoflavone daidzein recapitulated seizure induction in vivo and altered A?PP expression in vitro. These results have important implications for individuals on soy-based diets as well as for rodent model research. ..
- Seal R, Amara S. Excitatory amino acid transporters: a family in flux. Annu Rev Pharmacol Toxicol. 1999;39:431-56 pubmed..This review summarizes current knowledge of the structural and functional diversity of excitatory amino acid transporters and explores how they might serve as targets for drug design. ..
- Lee Y, McKinnon P. Responding to DNA double strand breaks in the nervous system. Neuroscience. 2007;145:1365-74 pubmed..Thus, there are distinct requirements for each DNA DSB repair pathway during neural development, which have important implications for understanding diseases of the nervous system...
- Hu X, Fan Q, Hou H, Yan R. Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling. J Neurochem. 2016;136:234-49 pubmed publisher..The dependence of Nrg on the cleavage by BACE1 is bestÂ manifested by disrupting the critical role of Nrg in the control of axonal myelination, schizophrenic behaviors as well as the formation and maintenance of muscle spindles. ..
- Ney J, Johnson B, Knabel T, Craft K, Kaufman J. Neurologist ambulatory care, health care utilization, and costs in a large commercial dataset. Neurology. 2016;86:367-74 pubmed publisher..Neurologist involvement with care is associated with greater unadjusted allowed payments, but fewer adverse events and less acute care utilization. ..
- Anji A, Kumari M. Guardian of Genetic Messenger-RNA-Binding Proteins. Biomolecules. 2016;6:4 pubmed publisher..We further discuss the conventional methods and newer techniques that are employed to identify RNA-binding proteins. ..
- Nadeau S, Wu S. CIMT as a behavioral engine in research on physiological adjuvants to neurorehabilitation: the challenge of merging animal and human research. NeuroRehabilitation. 2006;21:107-30 pubmed..We consider modifications in current approaches that might more efficiently advance neurorehabilitation science. ..
- Won J, Singh A, Singh I. Lactosylceramide: a lipid second messenger in neuroinflammatory disease. J Neurochem. 2007;103 Suppl 1:180-91 pubmed
- Thayer J, Sternberg E. Neural aspects of immunomodulation: focus on the vagus nerve. Brain Behav Immun. 2010;24:1223-8 pubmed publisher..Then we will provide an overview of what is known from both animal and human studies including neuroimaging and clinical studies. Finally, we will discuss some of the challenges and opportunities in this exciting area of investigation. ..
- Obermeier B, Daneman R, Ransohoff R. Development, maintenance and disruption of the blood-brain barrier. Nat Med. 2013;19:1584-96 pubmed publisher..We then discuss how BBB disruption can cause or contribute to neurological disease. Finally, we examine how this knowledge can be used to explore new possibilities for BBB repair. ..
- Wen R, Banik B, Pathak R, Kumar A, Kolishetti N, Dhar S. Nanotechnology inspired tools for mitochondrial dysfunction related diseases. Adv Drug Deliv Rev. 2016;99:52-69 pubmed publisher..In this review, we present an extensive coverage of possible therapeutic targets in different compartments of mitochondria for cancer, cardiovascular, and mitochondrial dysfunction related diseases. ..
- Cotten C, Goldstein R, McDonald S, Goldberg R, Salhab W, Carlo W, et al. Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. Pediatr Res. 2014;75:424-30 pubmed publisher..None of the differences were statistically significant. CP prevalence was also similar among genotype groups. Disability was not associated with the APOE genotype in this cohort of HIE survivors. ..
- Levine S, Wetzel D, Eilert A. Neuropathology of twitcher mice: examination by histochemistry, immunohistochemistry, lectin histochemistry and Fourier transform infrared microspectroscopy. Int J Dev Neurosci. 1994;12:275-88 pubmed
- Titsworth W, Hester J, Correia T, Reed R, Guin P, Archibald L, et al. The effect of increased mobility on morbidity in the neurointensive care unit. J Neurosurg. 2012;116:1379-88 pubmed publisher..Among neurointensive care unit patients, increased mobility can be achieved quickly and safely with associated reductions in LOS and hospital-acquired infections using the PUMP Plus program. ..
- Elmer J, Torres C, Aufderheide T, Austin M, Callaway C, Golan E, et al. Association of early withdrawal of life-sustaining therapy for perceived neurological prognosis with mortality after cardiac arrest. Resuscitation. 2016;102:127-35 pubmed publisher..After OHCA, death following WLST-N<72 may be common and is potentially avoidable. Reducing WLST-N<72 has national public health implications and may afford an opportunity to decrease mortality after OHCA. ..
- Gold B, Villafranca J. Neuroimmunophilin ligands: the development of novel neuroregenerative/ neuroprotective compounds. Curr Top Med Chem. 2003;3:1368-75 pubmed..We suggest that components of steroid receptor complexes are novel targets for the design of neuroregenerative/neuroprotective drugs. ..
- Sun J, Hu H, Ren X, Simpkins J. Tert-butylhydroquinone compromises survival in murine experimental stroke. Neurotoxicol Teratol. 2016;54:15-21 pubmed publisher..These data indicate that tBHQ-exacerbated stroke damage might due to the compromised BBB permeability in permanent stroke. ..
- McJunkin J, de los Reyes E, Irazuzta J, Caceres M, Khan R, Minnich L, et al. La Crosse encephalitis in children. N Engl J Med. 2001;344:801-7 pubmed..La Crosse encephalitis is a mosquito-borne disease that can be mistaken for herpes simplex encephalitis. It has been reported in 28 states but may be underrecognized...
- Vernino S, Lennon V. Autoantibody profiles and neurological correlations of thymoma. Clin Cancer Res. 2004;10:7270-5 pubmed..Serological evaluation of a patient's profile of neuronal and muscle autoantibodies may aid in preoperative identification of an indeterminate mediastinal mass. ..
- Huang Z. Molecular regulation of neuronal migration during neocortical development. Mol Cell Neurosci. 2009;42:11-22 pubmed publisher..These findings have not only enhanced our understanding of normal neuron migration but also revealed insights into the etiologies of several neurological diseases where these processes go awry. ..
- Rahman M, Bidari S, Quisling R, Friedman W. Spontaneous intracranial hypotension: dilemmas in diagnosis. Neurosurgery. 2011;69:4-14; discussion 14 pubmed publisher..Here, based on a comprehensive literature review, we describe the epidemiology, presentation, diagnostic workup and treatment of SIH. ..
- Struble R, Cady C, Nathan B, McAsey M. Apolipoprotein E may be a critical factor in hormone therapy neuroprotection. Front Biosci. 2008;13:5387-405 pubmed..Future studies of HT should evaluate the effects of apoE genotype and production estradiol on neuroprotection. ..
- Bidinost C, Matsumoto M, Chung D, Salem N, Zhang K, Stockton D, et al. Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities. Invest Ophthalmol Vis Sci. 2006;47:1274-80 pubmed..Also studied were two siblings who were homozygous for the PITX3 mutation who had microphthalmia and significant neurologic impairment...
- Vogelbaum M, Sampson J, Kunwar S, Chang S, Shaffrey M, Asher A, et al. Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase 1 study of final safety results. Neurosurgery. 2007;61:1031-7; discussion 1037-8 pubmed..CB (0.5 microg/mL) administered via convection-enhanced delivery before standard radiochemotherapy seems to be well tolerated in adults with newly diagnosed malignant gliomas. Further clinical study assessment is warranted. ..
- Hsiao Y, Tong Z, Westfall J, Ault J, Page McCaw P, Ferland R. Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking. Hum Mol Genet. 2009;18:3926-41 pubmed publisher..Overall, our data indicate that the distribution and functioning of Rab8a is regulated by Ahi1, not only affecting cilium formation, but also vesicle transport...
- Yao C, El Khoury R, Wang W, Byrd T, Pehek E, Thacker C, et al. LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease. Neurobiol Dis. 2010;40:73-81 pubmed publisher..These invertebrate models will be useful for studying pathogenesis of PD and for development of potential therapeutics for the disease. ..
- Harrington M, Aebersold R, Martin B, Merril C, Hood L. Identification of a brain-specific human cerebrospinal fluid glycoprotein, beta-trace protein. Appl Theor Electrophor. 1993;3:229-34 pubmed..Proteins of different mass and charge from beta-trace protein were clearly immunostained in samples of eight tissues.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Malley L, Hansen J, Everds N, Warheit D. 4-week inhalation toxicity study with a mixture of dichloroethylene and perfluorobutylethylene in rats. Inhal Toxicol. 2002;14:773-87 pubmed..Under the conditions of the study, the no-observed-effect level (NOEL) was 400 ppm in males and females based on clinical signs of toxicity during exposure to 2000 or 8000 ppm. ..
- Kent P, Michet C, Luthra H. Relapsing polychondritis. Curr Opin Rheumatol. 2004;16:56-61 pubmed..This article summarizes important aspects of the disease with a focus on recent information regarding clinical manifestations, disease associations, pathogenesis, and advances in therapeutics...
- Marra C, Maxwell C, Tantalo L, Eaton M, Rompalo A, Raines C, et al. Normalization of cerebrospinal fluid abnormalities after neurosyphilis therapy: does HIV status matter?. Clin Infect Dis. 2004;38:1001-6 pubmed..Future studies should address whether more intensive therapy for neurosyphilis is warranted in HIV-infected individuals...
- Fox C, Ramig L, Ciucci M, Sapir S, McFarland D, Farley B. The science and practice of LSVT/LOUD: neural plasticity-principled approach to treating individuals with Parkinson disease and other neurological disorders. Semin Speech Lang. 2006;27:283-99 pubmed
- Markowski V. Report of the 26th annual meeting of the Behavioral Toxicology Society. Neurotoxicol Teratol. 2007;29:586-7 pubmed
- Wortzel H, Oster T, Anderson C, Arciniegas D. Pathological laughing and crying : epidemiology, pathophysiology and treatment. CNS Drugs. 2008;22:531-45 pubmed
- Kim C, Waldman I, Blakely R, Kim K. Functional gene variation in the human norepinephrine transporter: association with attention deficit hyperactivity disorder. Ann N Y Acad Sci. 2008;1129:256-60 pubmed publisher..Moreover, we observed a significant association of the -3081(T) variant with ADHD. Altered transcription of SLC6A2 may therefore represent a novel risk factor for the development of ADHD. ..
- Pasternak J, Lanier W. Is nitrous oxide use appropriate in neurosurgical and neurologically at-risk patients?. Curr Opin Anaesthesiol. 2010;23:544-50 pubmed publisher..Except in a few specific circumstances, there exists no conclusive evidence to support the dogmatic avoidance of nitrous oxide in neurosurgical patients. ..
- Nakagawa S, Castro V, Toborek M. Infection of human pericytes by HIV-1 disrupts the integrity of the blood-brain barrier. J Cell Mol Med. 2012;16:2950-7 pubmed publisher..These findings indicate that human brain pericytes can be infected with HIV-1 and suggest that infected pericytes are involved in the progression of HIV-1-induced CNS damage. ..
- Oluigbo C, Salma A, Rezai A. Deep brain stimulation for neurological disorders. IEEE Rev Biomed Eng. 2012;5:88-99 pubmed publisher..The clinical results from studies on DBS show that it has great potential making it one of most promising fields which could be used to address challenging neurological problems. ..
- Backonja M, Attal N, Baron R, Bouhassira D, Drangholt M, Dyck P, et al. Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus. Pain. 2013;154:1807-19 pubmed publisher..When appropriate standards, as discussed here, are applied, QST can provide important and unique information about the functional status of somatosensory system, which would be complementary to already existing clinical methods. ..
- Melian E. Radiation therapy in neurologic disease. Handb Clin Neurol. 2014;121:1181-98 pubmed publisher..In addition we review the more commonly seen side effects and complications of treatment which may be seen by the neurologist. ..
- Heroux A, Pamboukian S. Neurologic aspects of heart transplantation. Handb Clin Neurol. 2014;121:1229-36 pubmed publisher..In children, seizures are the most common neurologic complication, although other neurologic complication rates are comparable. ..
- Raghuram V, Weber S, Raber J, Chen D, Bird T, Maylie J, et al. Assessment of mutations in KCNN2 and ZNF135 to patient neurological symptoms. Neuroreport. 2017;28:375-379 pubmed publisher..ZNF135 is expressed in human brain and it is likely that the homozygous mutation underlies the human phenotype. ..
- Buffington C. Comorbidity of interstitial cystitis with other unexplained clinical conditions. J Urol. 2004;172:1242-8 pubmed..Further investigation of the stress response system of patients with IC seems merited, which may provide novel approaches to therapy in some patients. ..
- Walker M, Zunt J. Neuroparasitic infections: cestodes, trematodes, and protozoans. Semin Neurol. 2005;25:262-77 pubmed..Spirometra spp. (sparganosis), Paragonimus spp., Schistosoma spp., Trypanosoma spp., Naegleria fowlerii, Acanthamoeba histolytica, and Balamuthia mandrillaris. ..
- Xia C, Smith R, Shen B, Yang Z, Borlongan C, Chao L, et al. Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor. Hypertension. 2006;47:752-61 pubmed..These results indicate that the kinin B2 receptor promotes survival and protects against brain injury by suppression of apoptosis and inflammation induced by ischemic stroke. ..
- Newton H, Padilla W, Burkart J, Pearl D. Neurological manifestations of decompression illness in recreational divers - the Cozumel experience. Undersea Hyperb Med. 2007;34:349-57 pubmed..001). Neurological manifestations are common in recreational divers treated for DCI. Neurological DCI and paresthesias are more likely to occur in younger and less experienced divers...
- Ramsdell J, Zabka T. In utero domoic acid toxicity: a fetal basis to adult disease in the California sea lion (Zalophus californianus). Mar Drugs. 2008;6:262-90 pubmed publisher..This analysis should provide a useful tool to forecast fetal toxicity and understand the impact of fetal toxicity on adult disease of the California sea lion...
- Kilburn K, Thrasher J, Immers N. Do terbutaline- and mold-associated impairments of the brain and lung relate to autism?. Toxicol Ind Health. 2009;25:703-10 pubmed publisher..Profile of mood status scores averaged 26.8 in terbutaline-exposed, 52 in mold exposed, and 26 in unexposed. The mean frequencies of 35 symptoms were 4.7 in terbutaline, 5.4 in mold/mycotoxins exposed and 1.7 in community controls...
- Alexandrov A, Tsivgoulis G, Rubiera M, Vadikolias K, Stamboulis E, Molina C, et al. End-diastolic velocity increase predicts recanalization and neurological improvement in patients with ischemic stroke with proximal arterial occlusions receiving reperfusion therapies. Stroke. 2010;41:948-52 pubmed publisher..Diastolic flow augmentation may represent a novel target for development of reperfusion therapies. ..
- Rosenfeld J, Crolla J, Tomkins S, Bader P, Morrow B, GORSKI J, et al. Refinement of causative genes in monosomy 1p36 through clinical and molecular cytogenetic characterization of small interstitial deletions. Am J Med Genet A. 2010;152A:1951-9 pubmed publisher..Characterization of small deletions is important for narrowing critical intervals and for the identification of causative or candidate genes for features of monosomy 1p36 syndrome...
- Chitravas N, Jung R, Kofskey D, Blevins J, Gambetti P, Leigh R, et al. Treatable neurological disorders misdiagnosed as Creutzfeldt-Jakob disease. Ann Neurol. 2011;70:437-44 pubmed publisher..Adherence to revised criteria for CJD, which include distinctive magnetic resonance imaging features of prion disease, is likely to improve diagnostic accuracy. ..
- Tseng H, Liu A, Sy L, Marcy S, Fireman B, Weintraub E, et al. Safety of zoster vaccine in adults from a large managed-care cohort: a Vaccine Safety Datalink study. J Intern Med. 2012;271:510-20 pubmed publisher..The aim of this study was to examine a large cohort of adults who received the zoster vaccine for evidence of an increased risk of prespecified adverse events requiring medical attention...
- Jethwa P, Lee J, Assina R, Keller I, Danish S. Treatment of a supratentorial primitive neuroectodermal tumor using magnetic resonance-guided laser-induced thermal therapy. J Neurosurg Pediatr. 2011;8:468-75 pubmed publisher..Postoperative imaging has shown no evidence of definitive recurrence at the 6-month follow-up period, but longer-term follow-up is required to assess for late recurrence...
- Klein C, Lennon V, Aston P, McKeon A, O Toole O, Quek A, et al. Insights from LGI1 and CASPR2 potassium channel complex autoantibody subtyping. JAMA Neurol. 2013;70:229-34 pubmed publisher..Additional antigenic components of VGKC macromolecular complexes remain to be defined. ..
- Baeza Yates R, Sangal P, Villoslada P. Burden of neurological diseases in the US revealed by web searches. PLoS ONE. 2017;12:e0178019 pubmed publisher..Web searches reflect the interest of people and the healthcare industry, and are based either on the frequency or social impact of the disease. ..
- Kao J, Liao B, Markovic S, Klein C, Naddaf E, Staff N, et al. Neurological Complications Associated With Anti-Programmed Death 1 (PD-1) Antibodies. JAMA Neurol. 2017;74:1216-1222 pubmed publisher..2%. To date, the clinical spectrum and optimum treatment approach are not established...
- Smeyne R, Klein R, Schnapp A, Long L, Bryant S, Lewin A, et al. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature. 1994;368:246-9 pubmed..These findings demonstrate that Trk is the primary mediator of the trophic actions of NGF in vivo and that this signalling pathway plays a crucial role in the development of both the peripheral and the central nervous systems. ..
- Sheikh F, Pahan K, Khan M, Barbosa E, Singh I. Abnormality in catalase import into peroxisomes leads to severe neurological disorder. Proc Natl Acad Sci U S A. 1998;95:2961-6 pubmed
- Mabry T. Selected topics from forty years of natural products research: betalains to flavonoids, antiviral proteins, and neurotoxic nonprotein amino acids. J Nat Prod. 2001;64:1596-604 pubmed..Following the betalain story and an account of the early development of my UT-Austin biochemical systematic program, the Phytolacca and neurotoxin investigations are discussed herein...
- Palladino M, Bower J, Kreber R, Ganetzky B. Neural dysfunction and neurodegeneration in Drosophila Na+/K+ ATPase alpha subunit mutants. J Neurosci. 2003;23:1276-86 pubmed..Our data show that maintenance of neuronal viability is dependent on normal sodium pump activity and establish Drosophila as a useful model for investigating the role of the pump in human neurodegenerative and seizure disorders. ..
- Huang D, Wujek J, Kidd G, He T, Cardona A, Sasse M, et al. Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice. FASEB J. 2005;19:761-72 pubmed..These results indicate that huGFAP-CCL2hi tg+ mice provide a useful model to study how chronic CNS expression of CCL2 alters microglial function and CNS physiology. ..
- Horlocker T, Hebl J, Gali B, Jankowski C, Burkle C, Berry D, et al. Anesthetic, patient, and surgical risk factors for neurologic complications after prolonged total tourniquet time during total knee arthroplasty. Anesth Analg. 2006;102:950-5 pubmed..048). We conclude that the likelihood of neurologic dysfunction increases with total tourniquet time and that a reperfusion interval only modestly decreases the risk of nerve injury. ..
- Kapadia R, Tureyen K, Bowen K, Kalluri H, Johnson P, Vemuganti R. Decreased brain damage and curtailed inflammation in transcription factor CCAAT/enhancer binding protein beta knockout mice following transient focal cerebral ischemia. J Neurochem. 2006;98:1718-31 pubmed..These results suggest a significant role for C/EBPbeta in postischemic inflammation and brain damage. ..
- Chung C, Koprich J, Siddiqi H, Isacson O. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. J Neurosci. 2009;29:3365-73 pubmed publisher..These findings can provide ideas for antecedent biomarkers and presymptomatic interventions in PD. ..
- Oh E, Maejima T, Liu C, Deneris E, Herlitze S. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. J Biol Chem. 2010;285:30825-36 pubmed publisher..Thus, as an optogenetic tool, Rh-CT(5-HT1A) has the potential to directly correlate in vivo 5-HT(1A) signaling with 5-HT neuron activity and behavior in both normal animals and animal models of neuropsychiatric disease. ..
- Spencer P, Kisby G, Ludolph A. Long-latency neurodegenerative disease in the western Pacific. Geriatrics. 1991;46 Suppl 1:37-42 pubmed..This paper explores the possible relationship between tumorigenesis and long-latency neurotoxicity, and discusses possible biologic markers of cycad exposure and subclinical neurodegenerative disease...