Genomes and Genes
Experts and Doctors on nerve tissue proteins in United States
Locale: United States
Topic: nerve tissue proteins
Publications613 found, 100 shown here
- Yurco P, Cameron D. Cellular correlates of proneural and Notch-delta gene expression in the regenerating zebrafish retina. Vis Neurosci. 2007;24:437-43 pubmed..A model of vertebrate retinal repair is suggested in which damage-induced expression of proneural genes, plus canonical Notch-Delta signaling, could contribute to retinal stem cell promotion and subsequent regenerative neurogenesis. ..
- Shiau C, Lwigale P, Das R, Wilson S, Bronner Fraser M. Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion. Nat Neurosci. 2008;11:269-76 pubmed publisher..The resultant disorganization mimics the effects of neural crest ablation. Thus, our data reveal a novel and essential role for Robo2-Slit1 signaling in mediating neural crest-placode interactions during trigeminal gangliogenesis. ..
- Hu B, Kong L, Matthews R, Viapiano M. The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility. J Biol Chem. 2008;283:24848-59 pubmed publisher..In addition, these results underscore the important functional implications of brevican processing in glioma progression. ..
- Zuba Surma E, Kucia M, Wu W, Klich I, Lillard J, Ratajczak J, et al. Very small embryonic-like stem cells are present in adult murine organs: ImageStream-based morphological analysis and distribution studies. Cytometry A. 2008;73A:1116-27 pubmed publisher..Further studies are needed to determine whether these cells, after being isolated from various adult human organs similarly to their murine BM-derived counterparts, are endowed with pluripotent stem cell properties. ..
- Hu B, Du Z, Li X, Ayala M, Zhang S. Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development. 2009;136:1443-52 pubmed publisher..2. Thus, despite the conservation of a similar transcriptional network across vertebrates, human stem/progenitor cells may respond differently to those of other vertebrates to certain extrinsic factors. ..
- Huang Z. Molecular regulation of neuronal migration during neocortical development. Mol Cell Neurosci. 2009;42:11-22 pubmed publisher..These findings have not only enhanced our understanding of normal neuron migration but also revealed insights into the etiologies of several neurological diseases where these processes go awry. ..
- Bevan A, Hutchinson K, Foust K, Braun L, McGovern V, Schmelzer L, et al. Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery. Hum Mol Genet. 2010;19:3895-905 pubmed publisher..Further cardiographic studies of human SMA patients are needed to clarify the clinical relevance of these findings from this SMA mouse. ..
- Gizard F, Zhao Y, Findeisen H, Qing H, Cohn D, Heywood E, et al. Transcriptional regulation of S phase kinase-associated protein 2 by NR4A orphan nuclear receptor NOR1 in vascular smooth muscle cells. J Biol Chem. 2011;286:35485-93 pubmed publisher..Collectively, these results characterize Skp2 as a novel NOR1-regulated target gene and detail a previously unrecognized transcriptional cascade regulating mitogen-induced VSMC proliferation. ..
- Chatterjee M, Li K, Chen L, Maisano X, Guo Q, Gan L, et al. Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes. Development. 2012;139:4633-43 pubmed publisher..Our findings illustrate the transcriptional control of differential expression of Robo1 and Robo2, which may play an important role in establishing the topography of TCAs. ..
- Domyan E, Branchfield K, Gibson D, Naiche L, Lewandoski M, Tessier Lavigne M, et al. Roundabout receptors are critical for foregut separation from the body wall. Dev Cell. 2013;24:52-63 pubmed publisher..In humans, genomic lesions containing Robo genes have been documented in CDH. Our findings suggest that separation of the foregut from the body wall is genetically controlled and that defects in this event may contribute to CDH. ..
- Hodge R, Garcia A, Elsen G, Nelson B, Mussar K, Reiner S, et al. Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus. J Neurosci. 2013;33:4165-80 pubmed publisher..These studies indicate that Tbr2 is explicitly required for morphogenesis of the DG and participates in multiple aspects of the intricate developmental process of this structure. ..
- Ibrahim B, Tamrakar P, Gujar A, Cherian A, Briski K. Caudal fourth ventricular administration of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside regulates glucose and counterregulatory hormone profiles, dorsal vagal complex metabolosensory neuron function, and hypothalamic Fos expression. J Neurosci Res. 2013;91:1226-38 pubmed publisher
- Glerup S, Olsen D, Vaegter C, Gustafsen C, Sjoegaard S, Hermey G, et al. SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014;82:1074-87 pubmed publisher..In conclusion, we have demonstrated that two-chain processing of SorCS2 enables neurons and glia to respond differently to proneurotrophins. ..
- Cordon Cardo C, Tapley P, Jing S, Nanduri V, O ROURKE E, Lamballe F, et al. The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. Cell. 1991;66:173-83 pubmed..These results indicate that the product of the trk proto-oncogene is sufficient to mediate signal transduction processes induced by NGF and NT-3, at least in proliferating cells. ..
- Baizer L, Alkan S, Stocker K, Ciment G. Chicken growth-associated protein (GAP)-43: primary structure and regulated expression of mRNA during embryogenesis. Brain Res Mol Brain Res. 1990;7:61-8 pubmed..In situ hybridization analysis reveals that GAP-43 RNA is expressed by several neural structures in the chick embryo, including derivatives of the neural tube, neural crest, and neuroectodermal placodes. ..
- Chang C, da Silva S, Ideta R, Lee Y, Yeh S, Burbach J. Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. Proc Natl Acad Sci U S A. 1994;91:6040-4 pubmed..Unlike TR2 orphan receptors, the TR4 orphan receptor appears to be predominantly located in granule cells of the hippocampus and the cerebellum, suggesting that it may play some role(s) in transcriptional regulation in these neurons. ..
- Fuss B, Baba H, Phan T, Tuohy V, Macklin W. Phosphodiesterase I, a novel adhesion molecule and/or cytokine involved in oligodendrocyte function. J Neurosci. 1997;17:9095-103 pubmed..These data together implicate the importance of p421.HB/PD-Ialpha in oligodendrocyte function, possibly through cell-cell and/or cell-extracellular matrix recognition...
- Kalandakanond S, Coffield J. Cleavage of SNAP-25 by botulinum toxin type A requires receptor-mediated endocytosis, pH-dependent translocation, and zinc. J Pharmacol Exp Ther. 2001;296:980-6 pubmed..Furthermore, the minimal amount of SNAP-25 cleavage at 1 h postparalysis suggests that inactivation of only a small but functionally important pool of SNAP-25 is necessary for paralysis. ..
- Deckel A, Tang V, Nuttal D, Gary K, Elder R. Altered neuronal nitric oxide synthase expression contributes to disease progression in Huntington's disease transgenic mice. Brain Res. 2002;939:76-86 pubmed..These findings indicate that nNOS activity is altered in a complex manner in HD transgenic mice and suggest that these abnormalities occur in the setting of a more global disturbance of calcium-regulated proteins. ..
- Zhang N, Townes Anderson E. Regulation of structural plasticity by different channel types in rod and cone photoreceptors. J Neurosci. 2002;22:7065-79 pubmed..The differing responses of rod and cone terminals to injury and disease may be determined by these differences in the regulation of Ca2+ influx. ..
- Zhang K, Davids E, Tarazi F, Baldessarini R. Serotonin transporter binding increases in caudate-putamen and nucleus accumbens after neonatal 6-hydroxydopamine lesions in rats: implications for motor hyperactivity. Brain Res Dev Brain Res. 2002;137:135-8 pubmed..These findings suggest that excess 5-HT transporters reflect serotonin hyperinnervation reported to occur in lesioned rats, and may modulate motor hyperactivity. ..
- Fischer A, Wang S, Reh T. NeuroD induces the expression of visinin and calretinin by proliferating cells derived from toxin-damaged chicken retina. Dev Dyn. 2004;229:555-63 pubmed..We conclude that NeuroD stimulates cells from the toxin-damaged chicken retina to acquire some neuronal phenotypes. We propose that most of these cells were derived from Müller glia. ..
- Filipovic R, Zecevic N. Lipopolysaccharide affects Golli expression and promotes proliferation of oligodendrocyte progenitors. Glia. 2005;49:457-66 pubmed..Taken together, these results demonstrate that microglia and/or microglia secreted factors, are necessary for the LPS-promoted proliferation of OPCs and suggest possible involvement of Golli proteins as one of mediators in this process. ..
- Ferrari D, Sanchez Pernaute R, Lee H, Studer L, Isacson O. Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft. Eur J Neurosci. 2006;24:1885-96 pubmed..Despite the heterogeneity of ES-derived graft cell composition, these results demonstrate normal phenotypic specification, conserved natural axonal target selectivity and functionality of DA neurons derived from primate ES cells. ..
- Yan Y, Jensen K, Brown A. The polypeptide composition of moving and stationary neurofilaments in cultured sympathetic neurons. Cell Motil Cytoskeleton. 2007;64:299-309 pubmed
- Ghai K, Stanke J, Fischer A. Patterning of the circumferential marginal zone of progenitors in the chicken retina. Brain Res. 2008;1192:76-89 pubmed..We propose that the microenvironment within the far peripheral retina at late stages of development permits the maintenance of a zone of progenitors and slows the differentiation of neurons. ..
- Coling D, Ding D, Young R, Lis M, Stofko E, Blumenthal K, et al. Proteomic analysis of cisplatin-induced cochlear damage: methods and early changes in protein expression. Hear Res. 2007;226:140-56 pubmed..Changes in cisplatin-induced protein expression are discussed with respect to known or hypothesized functions of the identified proteins. ..
- Park E, Choi S, Muse K, Curry T, Jo M. Response gene to complement 32 expression is induced by the luteinizing hormone (LH) surge and regulated by LH-induced mediators in the rodent ovary. Endocrinology. 2008;149:3025-36 pubmed publisher..In summary, the present study demonstrated the spatial/temporal-specific expression of Rgc32 in the ovary, and provided evidence of LH-initiated and RUNX1-mediated expression of Rgc32 gene in luteinizing granulosa cells. ..
- Maghirang Rodriguez R, Archie J, Schwartz C, Collins J. The c.940G variant of the Microcephalin (MCPH1) gene is not associated with microcephaly or mental retardation. Am J Med Genet A. 2009;149A:622-5 pubmed publisher..940G allele and either microcephaly or MR. However, we found highly significant racial differences in the c.940G > C SNP allele frequencies between African-American and Caucasian populations. ..
- Conrad A, Albrecht M, Pettit Scott M, Conrad G. Embryonic corneal Schwann cells express some Schwann cell marker mRNAs, but no mature Schwann cell marker proteins. Invest Ophthalmol Vis Sci. 2009;50:4173-84 pubmed publisher..Embryonic chick corneas contain SCs, as defined by SOX10 and PAX3 transcription, which remain immature, at least in part because of stromal transcriptional and epithelial translational regulation of some SC marker gene expression. ..
- Jossin Y, Cooper J. Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex. Nat Neurosci. 2011;14:697-703 pubmed publisher..However, inhibition of Rap1 or NCad had little effect on glia-dependent locomotion. We propose a multistep mechanism in which Reelin activates Rap1, Rap1 upregulates NCad, and NCad is needed to orient cell migration. ..
- Stephens C, Toda H, Palmer T, Demarse T, Ormerod B. Adult neural progenitor cells reactivate superbursting in mature neural networks. Exp Neurol. 2012;234:20-30 pubmed publisher..Future work exploring whether NPCs can re-stimulate developmental states in injury models would be an interesting test of their regenerative potential. ..
- Daniels G, Amara S. Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters. J Biol Chem. 1999;274:35794-801 pubmed..Phorbol ester-mediated alterations in the trafficking of the dopamine transporter may serve as a mechanism for controlling extracellular dopamine levels in the central nervous system. ..
- Pyle R, Schivell A, Hidaka H, Bajjalieh S. Phosphorylation of synaptic vesicle protein 2 modulates binding to synaptotagmin. J Biol Chem. 2000;275:17195-200 pubmed..These results suggest that the affinity of SV2 for synaptotagmin is modulated by phosphorylation of SV2. ..
- Littleton J, Bai J, Vyas B, Desai R, Baltus A, Garment M, et al. synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo. J Neurosci. 2001;21:1421-33 pubmed..These data suggest that Ca(2+)-driven oligomerization via the C2B domain of synaptotagmin may trigger synaptic vesicle fusion via the assembly and clustering of SNARE complexes. ..
- Tillerson J, Caudle W, Reveron M, Miller G. Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Exp Neurol. 2002;178:80-90 pubmed..Detection of dopamine-modulated behavioral changes in moderately depleted MPTP mice will allow for more efficacious use of this model in PD research. ..
- Himeda C, Ranish J, Angello J, Maire P, Aebersold R, Hauschka S. Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer. Mol Cell Biol. 2004;24:2132-43 pubmed..Our proteomics strategy will be useful for identifying transcription factors from complex mixtures using only defined DNA fragments for purification. ..
- Cai J, Qi Y, Hu X, Tan M, Liu Z, Zhang J, et al. Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron. 2005;45:41-53 pubmed..In addition, we provide genetic evidence that oligodendrogenesis can occur in the absence of hedgehog receptor Smoothened, which is essential for all hedgehog signaling. ..
- Wang E, Huang Z, Hobson G, Dimova N, Sperle K, McCullough A, et al. PLP1 alternative splicing in differentiating oligodendrocytes: characterization of an exonic splicing enhancer. J Cell Biochem. 2006;97:999-1016 pubmed..We conclude that an ESE in exon3B regulates PLP 5' donor site selection and that ASF/SF2 protein participates in the regulation of PLP alternative splicing in oligodendrocytes. ..
- Cannon A, Baker M, Boeve B, Josephs K, Knopman D, Petersen R, et al. CHMP2B mutations are not a common cause of frontotemporal lobar degeneration. Neurosci Lett. 2006;398:83-4 pubmed..Polymorphisms were detected but were present in control samples. We conclude that mutations in CHMP2B are a rare cause of familial FTLD and may be specific to the Danish pedigree. ..
- Rohacs T, Thyagarajan B, Lukacs V. Phospholipase C mediated modulation of TRPV1 channels. Mol Neurobiol. 2008;37:153-63 pubmed publisher..Finally, we also discuss data in the literature indicating that other TRP channels, TRPA1 and some members of the TRPC subfamily, may also be under a similar dual control by PIP2. ..
- Bennett K, Karpenko M, Lin M, Claus R, Arab K, Dyckhoff G, et al. Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. Cancer Res. 2008;68:4494-9 pubmed publisher..Interestingly, all of the candidates identified may be involved in the transforming growth factor beta signaling pathway, which is often disrupted in HNSCC. ..
- Anitei M, Cowan A, Pfeiffer S, Bansal R. Role for Rab3a in oligodendrocyte morphological differentiation. J Neurosci Res. 2009;87:342-52 pubmed publisher..Together, these findings indicate that Rab3a specifically stimulates morphological differentiation of mature oligodendrocytes and thus may be part of the necessary machinery for myelin membrane biogenesis. ..
- Ersahin C, Chivukula M, Bhargava R, Dabbs D. Basal-like subtype breast cancers in women older than 40 years of age. Int J Surg Pathol. 2010;18:42-7 pubmed publisher..BL cancer patients from all age groups require further investigation for BRCA-1, as well as gene microarray analysis to compare the gene expressions with those observed in the younger population. ..
- White R, McTigue D, Jakeman L. Regional heterogeneity in astrocyte responses following contusive spinal cord injury in mice. J Comp Neurol. 2010;518:1370-90 pubmed publisher..The results demonstrate that the astrocyte response to SCI is regionally heterogeneous, and suggests astrocyte populations that could be targeted by interventions. ..
- Chai S, Li M, Branigan D, Xiong Z, Simon R. Activation of acid-sensing ion channel 1a (ASIC1a) by surface trafficking. J Biol Chem. 2010;285:13002-11 pubmed publisher..These results reveal an important trafficking mechanism of ASIC1a that is relevant to both the normal physiology and the pathological activity of this channel. ..
- Takada N, Kucenas S, Appel B. Sox10 is necessary for oligodendrocyte survival following axon wrapping. Glia. 2010;58:996-1006 pubmed publisher..We conclude that, in addition to promoting myelin gene expression, Sox10 function is necessary for the survival of myelinating oligodedrocytes subsequent to axon wrapping but is not required for the survival of nonmyelinating OPCs. ..
- Sodhi M, Simmons M, McCullumsmith R, Haroutunian V, Meador Woodruff J. Glutamatergic gene expression is specifically reduced in thalamocortical projecting relay neurons in schizophrenia. Biol Psychiatry. 2011;70:646-54 pubmed publisher..Our findings indicate that glutamatergic innervation is dysfunctional in the circuitry between the medial dorsal thalamus and cortex. ..
- Nishimune H. Transsynaptic channelosomes: non-conducting roles of ion channels in synapse formation. Channels (Austin). 2011;5:432-9 pubmed publisher..This review will focus on the non-conducting functions of ion-channels that contribute to the synapse formation in concert with synapse organizers and active-zone-specific proteins. ..
- Schwend T, Lwigale P, Conrad G. Nerve repulsion by the lens and cornea during cornea innervation is dependent on Robo-Slit signaling and diminishes with neuron age. Dev Biol. 2012;363:115-27 pubmed publisher..Later, a shift in nerve guidance behavior occurs, in part due to molecular changes in trigeminal neurons, including Robo1 downregulation, thus allowing nerves to find the Slit-expressing cornea permissive for growth cones. ..
- Trotter J, Lee G, Kazdoba T, Crowell B, Domogauer J, Mahoney H, et al. Dab1 is required for synaptic plasticity and associative learning. J Neurosci. 2013;33:15652-68 pubmed publisher..Collectively, these data conclusively demonstrate an important role for Reelin-Dab1 signaling in the adult forebrain, and underscore the importance of this pathway in learning and memory. ..
- Hurd D, Saxton W. Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila. Genetics. 1996;144:1075-85 pubmed..These phenotypes parallel the pathologies of some vertebrate motor neuron diseases, including some forms of amyotrophic lateral sclerosis (ALS), and suggest that impaired fast axonal transport is a key element in these diseases. ..
- Tamimi R, Steingrimsson E, Montgomery Dyer K, Copeland N, Jenkins N, Tapscott S. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively. Genomics. 1997;40:355-7 pubmed..NEUROD2 maps to human chromosome 17q12 and mouse chromosome 11. NEUROD3 maps to human chromosome 5q23-q31 and mouse chromosome 13. ..
- Prichard L, Deloulme J, Storm D. Interactions between neurogranin and calmodulin in vivo. J Biol Chem. 1999;274:7689-94 pubmed..These data demonstrate that CaM is the major protein that interacts with neurogranin in vivo and support the hypothesis that phosphorylation of neurogranin at Ser-36 regulates its binding to CaM. ..
- Erickson J, Brosenitsch T, Katz D. Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor are required simultaneously for survival of dopaminergic primary sensory neurons in vivo. J Neurosci. 2001;21:581-9 pubmed..Together, these findings demonstrate that both GDNF and BDNF can act as target-derived trophic factors and are required simultaneously for survival of some primary sensory neurons. ..
- Klyachko V, Ahern G, Jackson M. cGMP-mediated facilitation in nerve terminals by enhancement of the spike afterhyperpolarization. Neuron. 2001;31:1015-25 pubmed..Thus, the cGMP/nitric oxide cascade generates a short-term, use-dependent enhancement of release. ..
- Chu X, Miesch J, Johnson M, Root L, Zhu X, Chen D, et al. Proton-gated channels in PC12 cells. J Neurophysiol. 2002;87:2555-61 pubmed..It might be an ideal neuronal cell line for the study of physiological and potential pathological roles of this key subunit of ASICs. ..
- Ganeshan R, Di A, Nelson D, Quick M, Kirk K. The interaction between syntaxin 1A and cystic fibrosis transmembrane conductance regulator Cl- channels is mechanistically distinct from syntaxin 1A-SNARE interactions. J Biol Chem. 2003;278:2876-85 pubmed..Thus, CFTR channel regulation by syntaxin 1A involves hydrophilic interactions that are mechanistically distinct from the hydrophobic interactions that mediate SNARE complex formation and Ca(2+) channel regulation by this t-SNARE. ..
- Hallows J, Chen K, Depinho R, Vincent I. Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice. J Neurosci. 2003;23:10633-44 pubmed..Our studies illustrate that p35 regulates the subcellular distribution of cdk5 and cytoskeletal proteins in neurons and that cdk5 has a hierarchical role in regulating the phosphorylation and function of cytoskeletal proteins. ..
- Zainelli G, Ross C, Troncoso J, Fitzgerald J, Muma N. Calmodulin regulates transglutaminase 2 cross-linking of huntingtin. J Neurosci. 2004;24:1954-61 pubmed..Inhibiting the interaction of calmodulin with transglutaminase and huntingtin protein could decrease cross-linking and diminish huntingtin aggregate formation in the HD brain. ..
- Bai J, Wang C, Richards D, Jackson M, Chapman E. Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions. Neuron. 2004;41:929-42 pubmed..Thus, the final step of Ca2+-triggered exocytosis is regulated, at least in part, by direct contacts between syt and SNAP-25/syntaxin. ..
- Crisp M, Liu Q, Roux K, Rattner J, Shanahan C, Burke B, et al. Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol. 2006;172:41-53 pubmed..2005), support a model in which Sun proteins tether nesprins in the ONM via interactions spanning the PNS. In this way, Sun proteins and nesprins form a complex that links the nucleoskeleton and cytoskeleton (the LINC complex). ..
- Hedstrom K, Xu X, Ogawa Y, Frischknecht R, Seidenbecher C, Shrager P, et al. Neurofascin assembles a specialized extracellular matrix at the axon initial segment. J Cell Biol. 2007;178:875-86 pubmed..Thus, NF-186 assembles and links the specialized brevican-containing AIS extracellular matrix to the intracellular cytoskeleton. ..
- Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass Belt P, et al. Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci U S A. 2007;104:14430-5 pubmed
- Cservenka A, Spangler E, Cote D, Ryabinin A. Postnatal developmental profile of urocortin 1 and cocaine- and amphetamine-regulated transcript in the perioculomotor region of C57BL/6J mice. Brain Res. 2010;1319:33-43 pubmed publisher..The lack of brain Ucn 1 immunoreactivity at birth and the gradual postnatal increase in Ucn 1 in pIIIu suggests that this peptide plays a greater behavioral role in adulthood than during the early postnatal development of an organism. ..
- Westmark P, Westmark C, Wang S, Levenson J, O Riordan K, Burger C, et al. Pin1 and PKMzeta sequentially control dendritic protein synthesis. Sci Signal. 2010;3:ra18 pubmed publisher..PKMzeta interacted with and inhibited Pin1 by phosphorylating serine 16. Therefore, glutamate-induced, dendritic protein synthesis is sequentially regulated by Pin1 and PKMzeta signaling. ..
- Schiro M, Stauber S, Peterson T, Krueger C, Darnell S, Satyshur K, et al. Mutations in protein-binding hot-spots on the hub protein Smad3 differentially affect its protein interactions and Smad3-regulated gene expression. PLoS ONE. 2011;6:e25021 pubmed publisher..This approach should be useful for unraveling which Smad3 protein complexes are critical for specific biological responses. ..
- Hota P, Buck M. Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions. Cell Mol Life Sci. 2012;69:3765-805 pubmed publisher..The structural information is helping the plexin field to focus on key questions at the protein structural, cellular, as well as organism level that collaboratoria of investigations are likely to answer. ..
- Robinson K, Mendonca J, Militar J, Theroux M, Dabney K, Shah S, et al. Disruption of basal lamina components in neuromotor synapses of children with spastic quadriplegic cerebral palsy. PLoS ONE. 2013;8:e70288 pubmed publisher..Thus, NMJ disruption in CP was found to principally involve components of the synaptic basal lamina and subtle ultra-structural modifications but appeared unrelated to neuromotor maturational status. ..
- Fromer M, Pocklington A, Kavanagh D, Williams H, Dwyer S, Gormley P, et al. De novo mutations in schizophrenia implicate synaptic networks. Nature. 2014;506:179-84 pubmed publisher..Aligning our findings with a parallel case-control study, we demonstrate reproducible insights into aetiological mechanisms for schizophrenia and reveal pathophysiology shared with other neurodevelopmental disorders. ..
- Birren S, Lo L, Anderson D. Sympathetic neuroblasts undergo a developmental switch in trophic dependence. Development. 1993;119:597-610 pubmed..They also suggest that the acquisition of NGF-dependence may occur, at least in part, through the loss of receptors for these interim survival factors. ..
- Horgan A, Lagrange M, Copenhaver P. A developmental role for the heterotrimeric G protein Go alpha in a migratory population of embryonic neurons. Dev Biol. 1995;172:640-53 pubmed..These results suggest that Go(alpha)-coupled signaling events within the EP cells may down-regulate their migratory behavior, possibly in response to inhibitory cues that normally guide migration in the developing embryo. ..
- Hassan B, Vaessin H. Regulatory interactions during early neurogenesis in Drosophila. Dev Genet. 1996;18:18-27 pubmed..While lineage identity genes allow the various lineages to acquire specific identities, neuronal precursor genes presumably regulate functional and developmental characteristics common to all neuronal precursor cells. ..
- Schivell A, Batchelor R, Bajjalieh S. Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin. J Biol Chem. 1996;271:27770-5 pubmed..Interaction is mediated by the cytoplasmic amino terminus of SV2A and the C2B domain of synaptotagmin. Our observations suggest a regulatory relationship between these two proteins. ..
- Micchelli C, Rulifson E, Blair S. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development. 1997;124:1485-95 pubmed..We propose that the boundary of Notch ligand along the normal margin plays a similar role as part of a dynamic feedback loop that maintains the tripartite pattern of margin gene expression. ..
- Lo L, Tiveron M, Anderson D. MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity. Development. 1998;125:609-20 pubmed
- Brown N, Murcia N. Delayed cystogenesis and increased ciliogenesis associated with the re-expression of polaris in Tg737 mutant mice. Kidney Int. 2003;63:1220-9 pubmed..Scanning electron microscopy was utilized to observe and measure cilia expression in cysts from orpk, orpk rescue, and KO rescue animals...
- Scruggs P, Dun S, Dun N. Cocaine- and amphetamine-regulated transcript peptide attenuates phenylephrine-induced bradycardia in anesthetized rats. Am J Physiol Regul Integr Comp Physiol. 2003;285:R1496-503 pubmed..The result suggests that endogenously released CARTp from primary afferents or exogenously administered CARTp modulates PE-induced baroreflex. ..
- Klezovitch O, Fernandez T, Tapscott S, Vasioukhin V. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev. 2004;18:559-71 pubmed
- Harfe B, Scherz P, Nissim S, Tian H, McMahon A, Tabin C. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. 2004;118:517-28 pubmed..Genetic studies of the effects of limiting accessibility of Shh within the limb support this model, in which the effect of the Shh morphogen is dictated by a temporal as well as a spatial gradient. ..
- Wolman M, Liu Y, Tawarayama H, Shoji W, Halloran M. Repulsion and attraction of axons by semaphorin3D are mediated by different neuropilins in vivo. J Neurosci. 2004;24:8428-35 pubmed..Together, these data support the hypothesis that Sema3D may act as a repellent through receptors containing Npn-1A and as an attractant via receptors containing Npn-1A and Npn-2B. ..
- Jung J, Kim T, Lyons G, Kim H, Lee Y. Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein. J Biol Chem. 2005;280:30916-23 pubmed..These data suggest that JMJ down-regulates the cell growth via interaction with Rb, which would provide important insights into the cardiac defects observed in jmj mutant mice. ..
- Ghosh J, Estrada M, Clark J. Interactive domains for chaperone activity in the small heat shock protein, human alphaB crystallin. Biochemistry. 2005;44:14854-69 pubmed..The results suggested that interactive sequences in human alphaB crystallin have dual roles in subunit-subunit assembly and chaperone activity. ..