Experts and Doctors on nad in Sweden


Locale: Sweden
Topic: nad

Top Publications

  1. Sabet Azad R, Linares Pastén J, Torkelson L, Sardari R, Hatti Kaul R. Coenzyme A-acylating propionaldehyde dehydrogenase (PduP) from Lactobacillus reuteri: kinetic characterization and molecular modeling. Enzyme Microb Technol. 2013;53:235-42 pubmed publisher
  2. Mardinoglu A, Björnson E, Zhang C, Klevstig M, Soderlund S, Ståhlman M, et al. Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD. Mol Syst Biol. 2017;13:916 pubmed publisher
    ..In a proof-of-concept human study, we found improved liver function and decreased HS after supplementation with serine (a precursor to glycine) and hereby propose a strategy for NAFLD treatment. ..
  3. Johansson F, Michalecka A, Møller I, Rasmusson A. Oxidation and reduction of pyridine nucleotides in alamethicin-permeabilized plant mitochondria. Biochem J. 2004;380:193-202 pubmed
  4. Stygar D, Masironi B, Eriksson H, Sahlin L. Studies on estrogen receptor (ER) alpha and beta responses on gene regulation in peripheral blood leukocytes in vivo using selective ER agonists. J Endocrinol. 2007;194:101-19 pubmed
    ..Our study demonstrates that peripheral blood leukocytes are responsive to estrogens. E2 and selective ERalpha and ERbeta agonists regulate a number of genes that may contribute to inflammation and remodeling of the extracellular matrix. ..
  5. H rlid A, Janke A, Arnason U. The complete mitochondrial genome of Rhea americana and early avian divergences. J Mol Evol. 1998;46:669-79 pubmed
    ..These findings challenge the commonly accepted notion that the most basal avian divergence is that between the Palaeognathae and Neognathae...
  6. Althage M, Karlsson J, Gourdon P, Levin M, Bill R, Tigerström A, et al. Functional split and crosslinking of the membrane domain of the beta subunit of proton-translocating transhydrogenase from Escherichia coli. Biochemistry. 2003;42:10998-1003 pubmed
    ..This is the first time that cross-linking between helices in the same beta subunit has been demonstrated. ..
  7. Wang E, Ikonen T, Knaapila M, Svergun D, Logan D, von Wachenfeldt C. Small-angle X-ray scattering study of a Rex family repressor: conformational response to NADH and NAD+ binding in solution. J Mol Biol. 2011;408:670-83 pubmed publisher
    ..The models emerging from this study indicate a reaction mechanism for B-Rex in which the recognition domains are rotated upon binding to NADH. ..
  8. Zafar M, Tasca F, Gorton L, Patridge E, Ferry J, Nöll G. Tryptophan repressor-binding proteins from Escherichia coli and Archaeoglobus fulgidus as new catalysts for 1,4-dihydronicotinamide adenine dinucleotide-dependent amperometric biosensors and biofuel cells. Anal Chem. 2009;81:4082-8 pubmed publisher
    ..0). Furthermore, an AfWrbA modified electrode was used as an anode in combination with a Pt black cathode as a biofuel cell prototype...
  9. Hoek J, Rydstrom J, Hojeberg B. Comparative studies on nicotinamide nucleotide transhydrogenase from different sources. Biochim Biophys Acta. 1974;333:237-45 pubmed
    ..coli, R. rubrum chromatophores and submitochondrial particles are closely connected with the interaction of the enzyme with an energy-conserving membrane system. ..

More Information


  1. Agren D, Stehr M, Berthold C, Kapoor S, Oehlmann W, Singh M, et al. Three-dimensional structures of apo- and holo-L-alanine dehydrogenase from Mycobacterium tuberculosis reveal conformational changes upon coenzyme binding. J Mol Biol. 2008;377:1161-73 pubmed publisher
    ..Amino acid replacements of these residues by site-directed mutagenesis led to inactive mutants, further emphasizing their essential roles in the enzymatic reaction mechanism. ..
  2. Laadan B, Almeida J, Radstrom P, Hahn Hägerdal B, Gorwa Grauslund M. Identification of an NADH-dependent 5-hydroxymethylfurfural-reducing alcohol dehydrogenase in Saccharomyces cerevisiae. Yeast. 2008;25:191-8 pubmed publisher
    ..Increased biomass production and HMF conversion rate were achieved in a CEN.PK S. cerevisiae strain overexpressing the mutated ADH1 gene. ..
  3. Oswald C, Johansson T, Törnroth S, Okvist M, Krengel U. Crystallization and preliminary crystallographic analysis of the NAD(H)-binding domain of Escherichia coli transhydrogenase. Acta Crystallogr D Biol Crystallogr. 2004;60:743-5 pubmed
    ..8, c = 76.4 A, alpha = 67.5, beta = 80.8, gamma = 81.5 degrees. X-ray diffraction data were collected to 1.9 A resolution using synchrotron radiation. The crystals contain one dimer of transhydrogenase domain I per asymmetric unit. ..
  4. Carlberg I, Nordlund S. Purification and partial characterization of glutamate synthase from Rhodospirillum rubrum grown under nitrogen-fixing conditions. Biochem J. 1991;279 ( Pt 1):151-4 pubmed
    ..The enzyme is inhibited by amidotransferase inhibitors at micromolar concentrations. The role of the enzyme in the metabolic regulation of nitrogenase is discussed...
  5. Pahlman I, Larsson C, Avéret N, Bunoust O, Boubekeur S, Gustafsson L, et al. Kinetic regulation of the mitochondrial glycerol-3-phosphate dehydrogenase by the external NADH dehydrogenase in Saccharomyces cerevisiae. J Biol Chem. 2002;277:27991-5 pubmed
    ..The physiological consequences of this regulation are discussed. ..
  6. Wahlbom C, Hahn Hägerdal B. Furfural, 5-hydroxymethyl furfural, and acetoin act as external electron acceptors during anaerobic fermentation of xylose in recombinant Saccharomyces cerevisiae. Biotechnol Bioeng. 2002;78:172-8 pubmed
    ..The enzymatic activity responsible for furfural reduction was considerably higher than for HMF reduction and also in situ furfural conversion was higher than HMF conversion. ..
  7. Bergkvist A, Johansson C, Johansson T, Rydstrom J, Karlsson B. Interactions of the NADP(H)-binding domain III of proton-translocating transhydrogenase from escherichia coli with NADP(H) and the NAD(H)-binding domain I studied by NMR and site-directed mutagenesis. Biochemistry. 2000;39:12595-605 pubmed
    ..Finally, by combining the above conclusions with information obtained by a further characterization of previously constructed mutants, the implications of the findings were considered in a mechanistic context. ..
  8. Bizouarn T, Fjellström O, Axelsson M, Korneenko T, Pestov N, Ivanova M, et al. Interactions between the soluble domain I of nicotinamide nucleotide transhydrogenase from Rhodospirillum rubrum and transhydrogenase from Escherichia coli. Effects on catalytic and H+-pumping activities. Eur J Biochem. 2000;267:3281-8 pubmed
    ..The reverse reaction and proton pumping showed a less pronounced change in pH dependence, demonstrating the regulatory role of domain II in these reactions. ..
  9. Rydstrom J, Hu X, Fjellström O, Meuller J, Zhang J, Johansson C, et al. Domains, specific residues and conformational states involved in hydride ion transfer and proton pumping by nicotinamide nucleotide transhydrogenase from Escherichia coli. Biochim Biophys Acta. 1998;1365:10-6 pubmed
    ..coli and Rhodospirillum rubrum at hand, the overall aim of the transhydrogenase research, the understanding of the conformationally driven proton pumping mechanism, is within reach. ..
  10. Larsson C, Påhlman I, Ansell R, Rigoulet M, Adler L, Gustafsson L. The importance of the glycerol 3-phosphate shuttle during aerobic growth of Saccharomyces cerevisiae. Yeast. 1998;14:347-57 pubmed
  11. Olausson T, Hultman T, Holmberg E, Rydstrom J, Ahmad S, Glavas N, et al. Site-directed mutagenesis of tyrosine residues at nicotinamide nucleotide binding sites of Escherichia coli transhydrogenase. Biochemistry. 1993;32:13237-44 pubmed
    ..These mutants were also active in proton pumping assayed as quenching of 9-methoxy-6-chloro-2-aminoacridine or quinacrine fluorescence.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  12. Nygard O, Nilsson L. Kinetic determination of the effects of ADP-ribosylation on the interaction of eukaryotic elongation factor 2 with ribosomes. J Biol Chem. 1990;265:6030-4 pubmed
    ..We conclude that the ADP-ribosylation affects both the association of the modified factor with pretranslocation ribosomes and the hydrolytic capacity of the factor. ..
  13. Pedersen A, Karlsson G, Rydström J. Proton-translocating transhydrogenase: an update of unsolved and controversial issues. J Bioenerg Biomembr. 2008;40:463-73 pubmed publisher
  14. Andersson M, Holmberg H, Adlercreutz P. Evaluation of Alcaligenes eutrophus cells as an NADH regenerating catalyst in organic-aqueous two-phase system. Biotechnol Bioeng. 1998;57:79-86 pubmed
    ..The use of this preparation in heptane (10% water) was optimized with respect to the yield obtained in the HLADH-catalyzed reduction of cyclohexanone. Using the optimized conditions, yields of 99% cyclohexanol were obtained...