Genomes and Genes
Experts and Doctors on multigene family in United States
Locale: United States
Topic: multigene family
Publications563 found, 100 shown here
- Hoyle H, Raff E. Two Drosophila beta tubulin isoforms are not functionally equivalent. J Cell Biol. 1990;111:1009-26 pubmed
- Matthews K, Miller D, Kaufman T. Developmental distribution of RNA and protein products of the Drosophila alpha-tubulin gene family. Dev Biol. 1989;132:45-61 pubmed..The developmental profiles of both synthesis and accumulation of these alpha-tubulin proteins are described. ..
- Perrot G, Cone K. Nucleotide sequence of the maize R-S gene. Nucleic Acids Res. 1989;17:8003 pubmed
- Stojiljkovic I, Bäumler A, Heffron F. Ethanolamine utilization in Salmonella typhimurium: nucleotide sequence, protein expression, and mutational analysis of the cchA cchB eutE eutJ eutG eutH gene cluster. J Bacteriol. 1995;177:1357-66 pubmed..Ethanolamine-utilization mutants were slightly attenuated in a mouse model of S. typhimurium infection, indicating that ethanolamine may be an important source of nitrogen and carbon for S. typhimurium in vivo...
- Lincoln J, Campbell A, Oetiker J, Rottmann W, Oeller P, Shen N, et al. LE-ACS4, a fruit ripening and wound-induced 1-aminocyclopropane-1-carboxylate synthase gene of tomato (Lycopersicon esculentum). Expression in Escherichia coli, structural characterization, expression characteristics, and phylogenetic analysis. J Biol Chem. 1993;268:19422-30 pubmed..The divergence of this sublineage is a relatively recent event in the evolution of ACC synthase protein. ..
- Fyodorov D, Nelson T, Deneris E. Pet-1, a novel ETS domain factor that can activate neuronal nAchR gene transcription. J Neurobiol. 1998;34:151-63 pubmed..Our results lead us to hypothesize that Pet-1 acts as a transcriptional regulator of downstream target genes involved in cholinergic neurotransmission. ..
- Lashbrook C, Tieman D, Klee H. Differential regulation of the tomato ETR gene family throughout plant development. Plant J. 1998;15:243-52 pubmed..Furthermore, the abundance of mRNAs for all three LeETR genes remained uniform in multiple plant tissues experiencing marked changes in ethylene sensitivity, including the cell separation layer throughout tomato flower abscission. ..
- Hickey W, Sabat G, Yuroff A, Arment A, Pérez Lesher J. Cloning, nucleotide sequencing, and functional analysis of a novel, mobile cluster of biodegradation genes from Pseudomonas aeruginosa strain JB2. Appl Environ Microbiol. 2001;67:4603-9 pubmed
- Drewell R, Bae E, Burr J, Lewis E. Transcription defines the embryonic domains of cis-regulatory activity at the Drosophila bithorax complex. Proc Natl Acad Sci U S A. 2002;99:16853-8 pubmed..We also discuss a possible mechanism by which this may occur. ..
- Hughes A. Birth-and-death evolution of protein-coding regions and concerted evolution of non-coding regions in the multi-component genomes of nanoviruses. Mol Phylogenet Evol. 2004;30:287-94 pubmed..Thus, there is a process of concerted evolution of non-coding regions of Nanovirus genome components, which raises the possibility that certain non-coding regions are subject to functional constraint...
- Schuenzel E, Scally M, Stouthamer R, Nunney L. A multigene phylogenetic study of clonal diversity and divergence in North American strains of the plant pathogen Xylella fastidiosa. Appl Environ Microbiol. 2005;71:3832-9 pubmed..The low level of variation within the X. fastidiosa subsp. piercei and X. fastidiosa subsp. sandyi clades, despite their antiquity, suggests strong selection, possibly driven by host plant adaptation. ..
- Wiemann P, Guo C, Palmer J, Sekonyela R, Wang C, Keller N. Prototype of an intertwined secondary-metabolite supercluster. Proc Natl Acad Sci U S A. 2013;110:17065-70 pubmed publisher..This blended design confounds predictions from established secondary-metabolite cluster search algorithms and provides an expanded view of natural product evolution. ..
- HESTER J, Chan E, Menard D, Mercereau Puijalon O, Barnwell J, Zimmerman P, et al. De novo assembly of a field isolate genome reveals novel Plasmodium vivax erythrocyte invasion genes. PLoS Negl Trop Dis. 2013;7:e2569 pubmed publisher..Further analyses of the novel protein coding genes discovered through de novo assembly have the potential to identify genes that influence key aspects of P. vivax biology, including alternative mechanisms of human erythrocyte invasion. ..
- Condon M, Hall A. Expression of thymosin beta-4 and related genes in developing human brain. J Mol Neurosci. 1992;3:165-70 pubmed
- Laughner B, Sehnke P, Ferl R. A novel nuclear member of the thioredoxin superfamily. Plant Physiol. 1998;118:987-96 pubmed
- Yu C. Molecular genetics of the human MHC complement gene cluster. Exp Clin Immunogenet. 1998;15:213-30 pubmed..The complete genomic DNA sequence between C2 and TNX is now available. This should facilitate a complete documentation of polymorphisms, mutations and disease associations for the MCGC. ..
- Liou L, Shi T, Duan Z, Sadhukhan P, Der S, Novick A, et al. Microarray gene expression profiling and analysis in renal cell carcinoma. BMC Urol. 2004;4:9 pubmed..This study reveals significant gene expression alterations in key biological pathways and provides potential insights into understanding the molecular mechanism of renal cell carcinogenesis. ..
- Thomas J. Concerted evolution of two novel protein families in Caenorhabditis species. Genetics. 2006;172:2269-81 pubmed..I speculate that these genes encode rapidly evolving antimicrobial peptides...
- Adams M, Goglin K, Molyneaux N, Hujer K, Lavender H, Jamison J, et al. Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii. J Bacteriol. 2008;190:8053-64 pubmed publisher..These genes are enriched for transcription factors and transporters and suggest physiological features of A. baumannii that are related to adaptation for growth in association with humans. ..
- Tietjen J, Zhang D, Rodríguez Molina J, White B, Akhtar M, Heidemann M, et al. Chemical-genomic dissection of the CTD code. Nat Struct Mol Biol. 2010;17:1154-61 pubmed publisher..We propose that Ser7-P could facilitate elongation and suppress cryptic transcription. ..
- Meijer W, Tabita F. Isolation and characterization of the nifUSVW-rpoN gene cluster from Rhodobacter sphaeroides. J Bacteriol. 1992;174:3855-66 pubmed..Similar regions were found in pyruvate carboxylase and oxaloacetate decarboxylase. It is proposed that these conserved regions represent keto acid-binding sites. ..
- Holland L, Suksang C, Wall A, Roberts L, Moser D, Bhattacharya A. A major estrogen-regulated protein secreted from the liver of Xenopus laevis is a member of the serpin superfamily. Nucleotide sequence of cDNA and hormonal induction of mRNA. J Biol Chem. 1992;267:7053-9 pubmed..Thus, both Ep45 and vitellogenin mRNAs are switched from undetectable to very high levels, a pattern of expression not found for any other mRNAs in Xenopus liver. ..
- Gibson J, Falcone D, Tabita F. Nucleotide sequence, transcriptional analysis, and expression of genes encoded within the form I CO2 fixation operon of Rhodobacter sphaeroides. J Biol Chem. 1991;266:14646-53 pubmed
- Shen L, Wu L, Sanlioglu S, Chen R, Mendoza A, Dangel A, et al. Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplic. J Biol Chem. 1994;269:8466-76 pubmed..Duplication of the RCCX modules probably occurred before the speciation of great apes and humans as they contain the same breakpoint region of RP and Gene X gene duplication. ..
- Yang P, Smalle J, Lee S, Yan N, Emborg T, Vierstra R. Ubiquitin C-terminal hydrolases 1 and 2 affect shoot architecture in Arabidopsis. Plant J. 2007;51:441-57 pubmed
- Matthews K, Miller D, Kaufman T. Functional implications of the unusual spatial distribution of a minor alpha-tubulin isotype in Drosophila: a common thread among chordotonal ligaments, developing muscle, and testis cyst cells. Dev Biol. 1990;137:171-83 pubmed..The cell types that express alpha 85E share a requirement for extensive cell shape changes during development, suggesting that this minor alpha-tubulin may have distinct functional properties. ..
- Lee S, Nicholls R, Jong M, Fukai K, Spritz R. Organization and sequence of the human P gene and identification of a new family of transport proteins. Genomics. 1995;26:354-63 pubmed..These results provide the basis for analyses of patients with OCA2 and may point toward eventual pharmacologic treatment of this and related disorders of pigmentation...
- Mueller P, Coleman T, Dunphy W. Cell cycle regulation of a Xenopus Wee1-like kinase. Mol Biol Cell. 1995;6:119-34 pubmed..These studies indicate that the down-regulation of Wee1-like kinase activity at mitosis is a multistep process that occurs after other biochemical reactions have signaled the successful completion of S phase. ..
- Warmke J, Ganetzky B. A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A. 1994;91:3438-42 pubmed
- Schiller N, Monday S, Boyd C, Keen N, Ohman D. Characterization of the Pseudomonas aeruginosa alginate lyase gene (algL): cloning, sequencing, and expression in Escherichia coli. J Bacteriol. 1993;175:4780-9 pubmed..Since alginate lyase activity is associated with the ability to produce and secrete alginate polymers, alginate lyase may play a role in alginate production. ..
- Muller H, Orwig K, Soares M. Identification of two new members of the mouse prolactin gene family. Biochim Biophys Acta. 1998;1396:251-8 pubmed..In summary, the two newly identified members share approximately 50% amino acid sequence identity, are specifically expressed in the placenta, and represent a new subfamily within the PRL family. ..
- Cheng Y, Tang G, Shen B. Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. Proc Natl Acad Sci U S A. 2003;100:3149-54 pubmed..This PKS structure provides opportunities for PKS engineering as exemplified by overexpressing lnmG to improve LNM production. ..
- Leang C, Coppi M, Lovley D. OmcB, a c-type polyheme cytochrome, involved in Fe(III) reduction in Geobacter sulfurreducens. J Bacteriol. 2003;185:2096-103 pubmed..These results indicate that OmcB, but not OmcC, has a major role in electron transport to Fe(III) and suggest that electron transport to the outer membrane is an important feature in Fe(III) reduction in this organism...
- Wargo M, Szwergold B, Hogan D. Identification of two gene clusters and a transcriptional regulator required for Pseudomonas aeruginosa glycine betaine catabolism. J Bacteriol. 2008;190:2690-9 pubmed..These studies provided important insight into both the mechanism and the regulation of the catabolism of GB in P. aeruginosa. ..
- Nichols Z, Vogt R. The SNMP/CD36 gene family in Diptera, Hymenoptera and Coleoptera: Drosophila melanogaster, D. pseudoobscura, Anopheles gambiae, Aedes aegypti, Apis mellifera, and Tribolium castaneum. Insect Biochem Mol Biol. 2008;38:398-415 pubmed publisher..The current state of knowledge of the characterized insect members of this gene family is discussed. ..
- Huang Y, Xiao Y, Allred D. Unusual chromatin structure associated with monoparalogous transcription of the Babesia bovis ves multigene family. Int J Parasitol. 2013;43:163-72 pubmed publisher..Based upon these results a working model is proposed for the chromatin structural remodeling responsible for the sequential expression of ves multigene family members from divergently-organized loci...
- Delgadillo Reynoso M, Rollo D, Hursh D, Raff R. Structural analysis of the uEGF gene in the sea urchin strongylocentrotus purpuratus reveals more similarity to vertebrate than to invertebrate genes with EGF-like repeats. J Mol Evol. 1989;29:314-27 pubmed..Thus, an alternative molecular datum is provided to support the hypothesis of echinoderm-chordate relationships. ..
- Frugoli J, Zhong H, Nuccio M, McCourt P, McPeek M, Thomas T, et al. Catalase is encoded by a multigene family in Arabidopsis thaliana (L.) Heynh. Plant Physiol. 1996;112:327-36 pubmed..Similarly, mRNA abundance of the three genes varies among organs. All three mRNAs are highly expressed in bolts, and CAT2 and CAT3 are highly expressed in leaves. ..
- Kwon H, Smith W, Scharon A, Hwang S, Kurth M, Shen B. C-O bond formation by polyketide synthases. Science. 2002;297:1327-30 pubmed..This chemistry can be used in PKS engineering to increase the scope and diversity of polyketide biosynthesis...
- Thomas M, Chan Y, Ozanick S. Deciphering tuberactinomycin biosynthesis: isolation, sequencing, and annotation of the viomycin biosynthetic gene cluster. Antimicrob Agents Chemother. 2003;47:2823-30 pubmed
- Collet C, Nielsen K, Russell R, Karl M, Oakeshott J, Richmond R. Molecular analysis of duplicated esterase genes in Drosophila melanogaster. Mol Biol Evol. 1990;7:9-28 pubmed..Southern and Northern blot hybridization analyses of the 20-kb region surrounding the Est-6/Est-P duplication failed to detect any other duplicated esterase genes, although this region is actively transcribed. ..
- Dickens M, Priestley N, Strohl W. In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA. J Bacteriol. 1997;179:2641-50 pubmed..strain C5 doxA, dauK, and dauP were sufficient and necessary to confer on Streptomyces lividans TK24 the ability to convert rhodomycin D, the first glycoside in daunorubicin and doxorubicin biosynthesis, to doxorubicin. ..
- Gaither L, Eide D. Functional expression of the human hZIP2 zinc transporter. J Biol Chem. 2000;275:5560-4 pubmed..Finally, hZip2 was exclusively localized in the plasma membrane. These results indicate that hZip2 is a zinc transporter, and its identification provides one of the first molecular tools to study zinc uptake in mammalian cells. ..
- Yu T, Muller R, Muller M, Zhang X, Draeger G, Kim C, et al. Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699. J Biol Chem. 2001;276:12546-55 pubmed..mediterranei. ..
- Park J, Easton D, Chen X, MacDonald I, Wang X, Subjeck J. The chaperoning properties of mouse grp170, a member of the third family of hsp70 related proteins. Biochemistry. 2003;42:14893-902 pubmed..The ability of the C-terminal region to bind peptides is a unique feature of grp170. ..
- Gaucher E, De Kee D, Benner S. Application of DETECTER, an evolutionary genomic tool to analyze genetic variation, to the cystic fibrosis gene family. BMC Genomics. 2006;7:44 pubmed..While this result validates this approach for this particular family of proteins only, the approach may be applicable to the analysis of polymorphisms generally, including SNPs in a human population. ..
- Chakravarti R, Adams J. Comparative genomics of the syndecans defines an ancestral genomic context associated with matrilins in vertebrates. BMC Genomics. 2006;7:83 pubmed..These conclusions provide the basis for a new model of syndecan evolution in vertebrates and a new perspective for analyzing the roles of syndecans in cells and whole organisms. ..
- Hughes A. Evolution of the lung surfactant proteins in birds and mammals. Immunogenetics. 2007;59:565-72 pubmed..Further, they imply that the loss of surfactant protein genes in the avian lineages formed part of major genomic rearrangement events that involved the loss of other genes as well. ..
- Tang X, Dong W, Griffith J, Nilsen R, Matthes A, Cheng K, et al. Systems biology of the qa gene cluster in Neurospora crassa. PLoS ONE. 2011;6:e20671 pubmed publisher..These studies illustrate new methodologies from systems biology to guide model-driven discoveries about a core metabolic network involving carbon and amino acid metabolism in N. crassa. ..
- Weyrich L, Rolin O, Muse S, Park J, Spidale N, Kennett M, et al. A Type VI secretion system encoding locus is required for Bordetella bronchiseptica immunomodulation and persistence in vivo. PLoS ONE. 2012;7:e45892 pubmed publisher..Together, these results reveal a natural host infection system in which to interrogate T6SS contributions to immunomodulation and pathogenesis. ..
- Allen B, Stein J, Stein G, Ostrer H. Single-copy flanking sequences in human histone gene clusters map to chromosomes 1 and 6. Genomics. 1991;10:486-8 pubmed..001). These findings agree with previous assignments of human histone genes to chromosomes 1 and 6 and demonstrate that the single-copy flanking sequences in different human histone gene clusters are unique for different chromosomes. ..
- Lader E, Ha H, O Neill M, Artzt K, Bennett D. tctex-1: a candidate gene family for a mouse t complex sterility locus. Cell. 1989;58:969-79 pubmed..The aberrant expression of tctex-1 is solely dependent on the t haplotype genes and occurs only in germ cells. The chromosomal location and pattern of expression of tctex-1 make it a candidate for involvement in male sterility. ..
- Roberts T, Chernova O, Cowell J. NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma. Hum Mol Genet. 1998;7:1169-78 pubmed..The chromosome rearrangement creates a fusion gene product which combines the TBC1 motif of NB4S with a polyadenylation signal from TRNG10 , potentially generating a truncated protein with oncogenic properties. ..
- Paris M, Williams B. Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5. Genomics. 2000;69:196-202 pubmed..The identification of potential disease genes within an organizational and evolutionary context provides valuable clues to function and as such will benefit our understanding of this region of the genome. ..
- Wu Y, Meeley R, Cosgrove D. Analysis and expression of the alpha-expansin and beta-expansin gene families in maize. Plant Physiol. 2001;126:222-32 pubmed..The results support the concept that beta-expansins multiplied and evolved special functions in the grasses. ..
- Bowen N, McDonald J. Drosophila euchromatic LTR retrotransposons are much younger than the host species in which they reside. Genome Res. 2001;11:1527-40 pubmed..melanogaster genome have transposed well after this species diverged from its closest relative Drosophila simulans, 2.3 +/-.3 million years ago...
- Clegg M, Durbin M. Tracing floral adaptations from ecology to molecules. Nat Rev Genet. 2003;4:206-15 pubmed..An exception is the morning glory genus Ipomoea, in which a broad picture of floral evolution, ranging from ecology to molecular biology, is emerging. ..
- Hughes A, Friedman R. Differential loss of ancestral gene families as a source of genomic divergence in animals. Proc Biol Sci. 2004;271 Suppl 3:S107-9 pubmed..These results indicate that the differential loss of ancestral gene families can be a significant factor in the evolutionary diversification of organisms. ..
- Tao L, Yao H, Kasai H, Misawa N, Cheng Q. A carotenoid synthesis gene cluster from Algoriphagus sp. KK10202C with a novel fusion-type lycopene beta-cyclase gene. Mol Genet Genomics. 2006;276:79-86 pubmed..A biosynthesis pathway for monocyclic flexixanthin was proposed in Algoriphagus sp. strain KK10202C, though several of the carotenoid synthesis genes not linked with the cluster have not yet been cloned. ..
- He H, Nagy R, Liyanarachchi S, Jiao H, Li W, Suster S, et al. A susceptibility locus for papillary thyroid carcinoma on chromosome 8q24. Cancer Res. 2009;69:625-31 pubmed publisher..Gene expression analysis indicated that AK023948 is significantly down-regulated in most PTC tumors. The putative noncoding RNA gene AK023948 is a candidate susceptibility gene for PTC. ..
- Lin G, Tepp W, Pier C, Jacobson M, Johnson E. Expression of the Clostridium botulinum A2 neurotoxin gene cluster proteins and characterization of the A2 complex. Appl Environ Microbiol. 2010;76:40-7 pubmed publisher..NTNH subtype-specific immunoreactivity was also discovered, allowing for the differentiation of subtypes based on cluster proteins associated with BoNT. ..
- Judelson H, Ah Fong A. The kinome of Phytophthora infestans reveals oomycete-specific innovations and links to other taxonomic groups. BMC Genomics. 2010;11:700 pubmed publisher..Little experimentation to date has addressed the biological functions of oomycete kinases, but this should be stimulated by the structural, evolutionary, and expression data presented here. This may lead to targets for disease control. ..
- Giles S, Soukup A, Lauer C, Shaaban M, Lin A, Oakley B, et al. Cryptic Aspergillus nidulans antimicrobials. Appl Environ Microbiol. 2011;77:3669-75 pubmed publisher..The ability of catalase to diminish this antimicrobial activity implicates reactive oxygen species generation, specifically, the generation of hydrogen peroxide, as the mechanism of emodin hydroxyl activity. ..
- Murphy T, Brauer A. Expression of urease by Haemophilus influenzae during human respiratory tract infection and role in survival in an acid environment. BMC Microbiol. 2011;11:183 pubmed publisher..Expression of urease enhances viability in an acid environment. Taken together, these observations suggest that urease is important for survival and replication of H. influenzae in the human respiratory tract. ..
- Hu J, Chen C, Peever T, Dang H, Lawrence C, Mitchell T. Genomic characterization of the conditionally dispensable chromosome in Alternaria arborescens provides evidence for horizontal gene transfer. BMC Genomics. 2012;13:171 pubmed publisher..Genes encoding these toxins are well-studied, however the genomic content and organization of the CDC is not known...
- Bisgrove B, Andrews M, Raff R. Fibropellins, products of an EGF repeat-containing gene, form a unique extracellular matrix structure that surrounds the sea urchin embryo. Dev Biol. 1991;146:89-99 pubmed..The molecular weights of the fibropellins and their pattern of embryonic localization indicate that these proteins form a component of the hyaline layer previously described as the apical lamina. ..
- Diederich R, Merrill V, Pultz M, Kaufman T. Isolation, structure, and expression of labial, a homeotic gene of the Antennapedia Complex involved in Drosophila head development. Genes Dev. 1989;3:399-414 pubmed..Finally, we suggest that lab head expression provides a molecular marker for an intercalary segment, an ancestral segment that has become morphologically indistinct during the evolution of the insect head. ..
- Brown S, Rhoads D, Stewart M, Van Slyke B, Chen I, Johnson T, et al. Ribosomal protein S14 is encoded by a pair of highly conserved, adjacent genes on the X chromosome of Drosophila melanogaster. Mol Cell Biol. 1988;8:4314-21 pubmed..Drosophila RPS14 was mapped to region 7C5-9 on the X chromosome. This interval also encodes a previously characterized Minute locus, M(1)7C. ..
- Pajovic S, Jones V, Prowse K, Berger F, Baumann H. Species-specific changes in regulatory elements of mouse haptoglobin genes. J Biol Chem. 1994;269:2215-24 pubmed..domesticus and M. saxicola, but not M. caroli. The specific regulatory effects of glucocorticoid receptor, C/EBP beta, and Ets proteins were documented by co-transfection. ..
- De Beer M, de Beer F, McCubbin W, Kay C, Kindy M. Structural prerequisites for serum amyloid A fibril formation. J Biol Chem. 1993;268:20606-12 pubmed..15 isoform fails to undergo the beta-sheet folding typical for apo-SAA2. This evidence suggests that the folding effect of heparan sulfate proteoglycan on apo-SAA2 is important in amyloid formation. ..
- McConnell T, Godwin U, Norton S, Nairn R, Kazianis S, Morizot D. Identification and mapping of two divergent, unlinked major histocompatibility complex class II B genes in Xiphophorus fishes. Genetics. 1998;149:1921-34 pubmed..maculatus DXB sequence in the conserved beta2-encoding exon and was mapped to new unassigned linkage group LG U24. The DXB gene, then, represents an unlinked duplicated locus not previously identified in teleosts...
- Delgado Nixon V, Gonzalez G, Gilles Gonzalez M. Dos, a heme-binding PAS protein from Escherichia coli, is a direct oxygen sensor. Biochemistry. 2000;39:2685-91 pubmed..Overall the results provide evidence for a heme-binding subgroup of PAS-domain proteins whose working range, signaling mechanisms, and regulatory partners can vary considerably. ..
- Locke D, Archidiacono N, Misceo D, Cardone M, Deschamps S, Roe B, et al. Refinement of a chimpanzee pericentric inversion breakpoint to a segmental duplication cluster. Genome Biol. 2003;4:R50 pubmed..This study further exemplifies the genomic plasticity due to the presence of segmental duplications and highlights their importance for a complete understanding of genome evolution. ..
- Rooney A, Ward T. Evolution of a large ribosomal RNA multigene family in filamentous fungi: birth and death of a concerted evolution paradigm. Proc Natl Acad Sci U S A. 2005;102:5084-9 pubmed..As such, we hypothesize that a mechanism resembling retroposition controls 5S rRNA gene amplification, dispersal, and integration in the genomes of filamentous fungi. ..
- Dutko J, Schäfer A, Kenny A, Cullen B, Curcio M. Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases. Curr Biol. 2005;15:661-6 pubmed..Our findings indicate that APOBEC3G restricts Ty1 and HIV-1 by similar mechanisms and suggest that the APOBEC3 proteins target a substantially broader spectrum of retroelements than previously appreciated. ..
- Giel J, Rodionov D, Liu M, Blattner F, Kiley P. IscR-dependent gene expression links iron-sulphur cluster assembly to the control of O2-regulated genes in Escherichia coli. Mol Microbiol. 2006;60:1058-75 pubmed..The findings presented here indicate a more general role of IscR in the regulation of Fe-S cluster biogenesis and that IscR contributes to the O(2) regulation of several promoters controlling the expression of anaerobic Fe-S proteins. ..
- Chourey K, Thompson M, Morrell Falvey J, Verberkmoes N, Brown S, Shah M, et al. Global molecular and morphological effects of 24-hour chromium(VI) exposure on Shewanella oneidensis MR-1. Appl Environ Microbiol. 2006;72:6331-44 pubmed
- Sasaki E, Ogasawara Y, Liu H. A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product. J Am Chem Soc. 2010;132:7405-17 pubmed publisher..On the basis of these genetic and biochemical experiments, a biosynthetic pathway for BE-7585A can now be proposed. The combined results set the stage for future biochemical studies of 2-thiosugar biosynthesis and BE-7585A assembly. ..
- Smith H, Cronk R, Lang J, McNeel D. Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer. Cancer Res. 2011;71:6785-95 pubmed publisher..Our findings suggest that multiple SSX family members are expressed in metastatic prostate cancers which are amenable to simultaneous targeting. ..
- Wanner L, Li G, Ware D, Somssich I, Davis K. The phenylalanine ammonia-lyase gene family in Arabidopsis thaliana. Plant Mol Biol. 1995;27:327-38 pubmed..thaliana PAL1 and PAL2, as well as motifs described in other genes involved in phenylpropanoid metabolism. A. thaliana PAL3 was expressed at very low levels under the conditions examined. ..
- Ringer K, Davis E, Croteau R. Monoterpene metabolism. Cloning, expression, and characterization of (-)-isopiperitenol/(-)-carveol dehydrogenase of peppermint and spearmint. Plant Physiol. 2005;137:863-72 pubmed
- Karimpour Fard A, Leach S, Gill R, HUNTER L. Predicting protein linkages in bacteria: which method is best depends on task. BMC Bioinformatics. 2008;9:397 pubmed publisher..We used several benchmarks on which we have shown the comparative effectiveness of each prediction method, as well as provided guidelines as to which method is most appropriate for a given prediction task. ..
- Parrott A, Sriram G, Liu Y, Mathews M. Expression of type II chorionic gonadotropin genes supports a role in the male reproductive system. Mol Cell Biol. 2011;31:287-99 pubmed publisher..A novel peptide is encoded by alternatively spliced transcripts. These findings support the view that type II genes evolved in African great apes to function in the male reproductive system. ..
- Peremyslov V, Mockler T, Filichkin S, Fox S, Jaiswal P, Makarova K, et al. Expression, splicing, and evolution of the myosin gene family in plants. Plant Physiol. 2011;155:1191-204 pubmed publisher..Phylogenetic reconstructions indicate that the last common ancestor of the angiosperms possessed two myosins VIII and five myosins XI, many of which underwent additional lineage-specific duplications...
- Zha Y, Ding E, Yang L, Mao L, Wang X, McCarthy B, et al. Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation. PLoS ONE. 2012;7:e40728 pubmed publisher..HOXD8 directly activates the transcription of HOXC9, a key effector of RA action in neuroblastoma cells. These findings highlight the distinct functions of HOXD genes in RA induction of neuroblastoma cell differentiation. ..
- Proctor R, Van Hove F, Susca A, Stea G, Busman M, van der Lee T, et al. Birth, death and horizontal transfer of the fumonisin biosynthetic gene cluster during the evolutionary diversification of Fusarium. Mol Microbiol. 2013;90:290-306 pubmed publisher..Thus, uniform gene organization within the FUM cluster belies a complex evolutionary history that has not always paralleled the evolution of Fusarium. ..
- Johnson M, Malley C, Goffinet B, Shaw A, Wickett N. A phylotranscriptomic analysis of gene family expansion and evolution in the largest order of pleurocarpous mosses (Hypnales, Bryophyta). Mol Phylogenet Evol. 2016;98:29-40 pubmed publisher..Our results reveal candidate genes and pathways that may be associated with the transition to pleurocarpy, illustrating the utility of phylotranscriptomics for the study of molecular evolution in non-model species. ..
- Abranches J, Chen Y, Burne R. Characterization of Streptococcus mutans strains deficient in EIIAB Man of the sugar phosphotransferase system. Appl Environ Microbiol. 2003;69:4760-9 pubmed