Experts and Doctors on multienzyme complexes in Brazil


Locale: Brazil
Topic: multienzyme complexes

Top Publications

  1. Dias M, Mesquita J, Filgueira A, de Souza W. Human neutrophils susceptibility to Paracoccidioides brasiliensis: an ultrastructural and cytochemical assay. Med Mycol. 2008;46:241-9 pubmed publisher
    ..Hence, this work demonstrates the existence of a functional neutrophil deficiency against P. brasiliensis in susceptible individuals. The exact origin of this susceptibility is still to be determined in further studies. ..
  2. Chagas R, Bailão A, Fernandes K, Winters M, Pereira M, Soares C. Purification of Paracoccidioides brasiliensis catalase P: subsequent kinetic and stability studies. J Biochem. 2010;147:345-51 pubmed publisher
    ..The results demonstrated that a purified PbCatP is a homotetrameric enzyme, classified as a small subunit catalase. ..
  3. de Camargo A, Regitano d Arce M, Biasoto A, Shahidi F. Enzyme-assisted extraction of phenolics from winemaking by-products: Antioxidant potential and inhibition of alpha-glucosidase and lipase activities. Food Chem. 2016;212:395-402 pubmed publisher
    ..Solubility plays an important role in the bioavailability of phenolic compounds, hence this study may assist in better exploitation of phenolics from winemaking by-products as functional food ingredients and/or supplements. ..
  4. Aguirre A, Vicente A, Hardwick S, Alvelos D, Mazzon R, Luisi B, et al. Association of the Cold Shock DEAD-Box RNA Helicase RhlE to the RNA Degradosome in Caulobacter crescentus. J Bacteriol. 2017;199: pubmed publisher
    ..These results suggest that RhlE has a specific role in the degradosome at low temperature, potentially improving adaptation to this condition. ..
  5. Santos C, Stolf B, Takemoto P, Amanso A, Lopes L, Souza E, et al. Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages. J Leukoc Biol. 2009;86:989-98 pubmed publisher
    ..These results provide evidence that PDI not only associates with phagocyte NADPH oxidase but also that PDI is crucial for efficient macrophage infection by L. chagasi. ..
  6. Melo D, Mirandola S, Assunção N, Castilho R. Methylmalonate impairs mitochondrial respiration supported by NADH-linked substrates: involvement of mitochondrial glutamate metabolism. J Neurosci Res. 2012;90:1190-9 pubmed publisher
    ..Taken together, these findings indicate that the inhibitory effect of MMA on mitochondrial oxidative metabolism can be ascribed to concurrent inhibition of specific enzymes and lower availability of respiratory substrates. ..
  7. Dos Santos Costa P, Büchli F, Robl D, Delabona P, Rabelo S, Pradella J. Enhancement of Penicillium echinulatum glycoside hydrolase enzyme complex. J Ind Microbiol Biotechnol. 2016;43:627-39 pubmed publisher
    ..echinulatum using adjustment of the culture medium composition. The proposed strategy may contribute to increase enzymatic hydrolysis of lignocellulosic materials. ..
  8. Papes F, Kemper E, Cord Neto G, Langone F, Arruda P. Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. Biochem J. 1999;344 Pt 2:555-63 pubmed
    ..Lysine-injected mice also show an increase in lysine-oxoglutarate reductase and saccharopine dehydrogenase levels. ..
  9. Bellinaso M, Henriques J, Gaylarde C, Greer C. Genes similar to naphthalene dioxygenase genes in trifluralin-degrading bacteria. Pest Manag Sci. 2004;60:474-8 pubmed
    ..This is the first publication on genes in trifluralin-degrading bacteria...

More Information


  1. Barros M, Johnson A, Gin P, Marbois B, Clarke C, Tzagoloff A. The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration. J Biol Chem. 2005;280:42627-35 pubmed
    ..032-0.034 mol of Q6/mol of protein. We propose that Coq10p is a Q6-binding protein and that in the coq10 mutant Q6 it is not able to act as an electron carrier, possibly because of improper localization. ..
  2. Mingatto F, Dorta D, dos Santos A, Carvalho I, da Silva C, da Silva V, et al. Dehydromonocrotaline inhibits mitochondrial complex I. A potential mechanism accounting for hepatotoxicity of monocrotaline. Toxicon. 2007;50:724-30 pubmed
    ..The mechanism probably involves change of the complex I conformation resulting from modification of cysteine thiol groups by the metabolite...
  3. Ropelle E, Pauli J, Zecchin K, Ueno M, De Souza C, Morari J, et al. A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia. Endocrinology. 2007;148:5220-9 pubmed
    ..Thus, our data indicate that hypothalamic AMPK activation presents an attractive opportunity for the treatment of cancer-induced anorexia. ..
  4. Cesquini M, Stoppa G, Prada P, Torsoni A, Romanatto T, Souza A, et al. Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats. Life Sci. 2008;82:1262-71 pubmed publisher
  5. Trevisol E, Panek A, De Mesquita J, Eleutherio E. Regulation of the yeast trehalose-synthase complex by cyclic AMP-dependent phosphorylation. Biochim Biophys Acta. 2014;1840:1646-50 pubmed publisher
    ..A better understanding of TPS complex regulation is essential for understanding how yeast deals with stress situations and how it is able to recover when the stress is over. ..