Experts and Doctors on mrna cleavage and polyadenylation factors in United Kingdom
Locale: United Kingdom
Topic: mrna cleavage and polyadenylation factors
Hollingworth D, Noble C, Taylor I, Ramos A. RNA polymerase II CTD phosphopeptides compete with RNA for the interaction with Pcf11. RNA. 2006;12:555-60 pubmed
..We propose that competition between the protein-peptide and the protein-RNA interaction is important mechanistically and required for the disengagement of polyadenylation factors from RNAPII. ..
Santos Rosa H, Schneider R, Bernstein B, Karabetsou N, Morillon A, Weise C, et al
. Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin. Mol Cell. 2003;12:1325-32 pubmed
..These results indicate that K4 H3 methylation and Isw1p ATPase activity are intimately linked in regulating transcription of certain genes in yeast. ..
Barilla D, Lee B, Proudfoot N. Cleavage/polyadenylation factor IA associates with the carboxyl-terminal domain of RNA polymerase II in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2001;98:445-50 pubmed
..Moreover, these data reinforce the concept that CTD phosphorylation acts as a regulatory mechanism in the maturation of the primary transcript. ..
Aranda A, Proudfoot N. Transcriptional termination factors for RNA polymerase II in yeast. Mol Cell. 2001;7:1003-11 pubmed
..Deletion of res2 in both fission and budding yeast results in a defect in 3' end formation. This raises the possibility that RNAP II transcriptional termination may in some situations be integrated with cell cycle events. ..
Wang S, Asakawa K, Win T, Toda T, Norbury C. Inactivation of the pre-mRNA cleavage and polyadenylation factor Pfs2 in fission yeast causes lethal cell cycle defects. Mol Cell Biol. 2005;25:2288-96 pubmed
..Mutations in pfs2 were suppressed by overexpression of the putative mRNA 3'-end cleavage factor Cft1. These data suggest unexpected links between mRNA 3'-end processing and chromosome replication and segregation. ..
Manzano D, Marquardt S, Jones A, Bäurle I, Liu F, Dean C. Altered interactions within FY/AtCPSF complexes required for Arabidopsis FCA-mediated chromatin silencing. Proc Natl Acad Sci U S A. 2009;106:8772-7 pubmed publisher
..These altered interactions would appear to be a necessary step in this RNA-mediated chromatin silencing. ..
Rasaiyaah J, Tan C, Fletcher A, Price A, Blondeau C, Hilditch L, et al
. HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature. 2013;503:402-405 pubmed publisher
..We conclude that HIV-1 has evolved to use CPSF6 and cyclophilins to cloak its replication, allowing evasion of innate immune sensors and induction of a cell-autonomous innate immune response in primary human macrophages. ..
Maertens G, Cook N, Wang W, Hare S, Gupta S, Oztop I, et al
. Structural basis for nuclear import of splicing factors by human Transportin 3. Proc Natl Acad Sci U S A. 2014;111:2728-33 pubmed publisher
..Our results elucidate the structural bases for nuclear import of splicing factors and the Tnpo3-CPSF6 nexus in HIV-1 biology. ..
Volanakis A, Kamieniarz Gdula K, Schlackow M, Proudfoot N. WNK1 kinase and the termination factor PCF11 connect nuclear mRNA export with transcription. Genes Dev. 2017;31:2175-2185 pubmed publisher
..We predict that WNK1 and the associated phosphorylation of the PCF11 CID act to promote transcript release from chromatin-associated Pol II. This in turn facilitates mRNA export to the cytoplasm. ..