Experts and Doctors on monophenol monooxygenase in Japan


Locale: Japan
Topic: monophenol monooxygenase

Top Publications

  1. Ando H, Ryu A, Hashimoto A, Oka M, Ichihashi M. Linoleic acid and alpha-linolenic acid lightens ultraviolet-induced hyperpigmentation of the skin. Arch Dermatol Res. 1998;290:375-81 pubmed
  2. Sunagawa G, Sumiyama K, Ukai Tadenuma M, Perrin D, Fujishima H, Ukai H, et al. Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene. Cell Rep. 2016;14:662-677 pubmed publisher
    ..These results demonstrate the application of mammalian reverse genetics without crossing to organism-level systems biology in sleep research. ..
  3. Nakamura K, Ozaki A, Akutsu T, Iwai K, Sakamoto T, Yoshizaki G, et al. Genetic mapping of the dominant albino locus in rainbow trout (Oncorhynchus mykiss). Mol Genet Genomics. 2001;265:687-93 pubmed
    ..The markers identified here will facilitate cloning of the dominant albino gene in rainbow trout and contribute to a better understanding of tyrosinase-negative OCA in animals. ..
  4. Matsuyama K, Villareal M, El Omri A, Han J, Kchouk M, Isoda H. Effect of Tunisian Capparis spinosa L. extract on melanogenesis in B16 murine melanoma cells. J Nat Med. 2009;63:468-72 pubmed publisher
  5. Yamazaki Y, Kawano Y, Yamanaka A, Maruyama S. N-[(Dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells. Bioorg Med Chem Lett. 2009;19:4178-82 pubmed publisher
    ..Their inhibition of tyrosinase is primarily performed through the 5-hydroxyindole moiety and further strengthened by the phenolic hydroxyl groups in the acyl moiety. ..
  6. Jimbow K, Hua C, Gomez P, Hirosaki K, Shinoda K, Salopek T, et al. Intracellular vesicular trafficking of tyrosinase gene family protein in eu- and pheomelanosome biogenesis. Pigment Cell Res. 2000;13 Suppl 8:110-7 pubmed
  7. Tomita Y, Miyamura Y, Kono M, Nakamura R, Matsunaga J. Molecular bases of congenital hypopigmentary disorders in humans and oculocutaneous albinism 1 in Japan. Pigment Cell Res. 2000;13 Suppl 8:130-4 pubmed
    ..The disease gene and its chromosomal localization have not been identified yet. Our trial of linkage analysis and positional cloning to determine the disease gene is presented. ..
  8. Ito S, Nishigaki A, Ishii Osai Y, Ojika M, Wakamatsu K, Yamashita T, et al. Mechanism of putative neo-antigen formation from N-propionyl-4-S-cysteaminylphenol, a tyrosinase substrate, in melanoma models. Biochem Pharmacol. 2012;84:646-53 pubmed publisher
    ..NPrCAP thus represents a potential new approach to immunotherapy against metastatic melanoma. ..
  9. Gocho K, Kondo I, Yamaki K. Identification of autoreactive T cells in Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci. 2001;42:2004-9 pubmed
    ..To determine the finer specificity and immunologic features of autoreactive T cells in Vogt-Koyanagi-Harada (VKH) disease...

More Information


  1. Shirasugi I, Sakakibara Y, Yamasaki M, Nishiyama K, Matsui T, Liu M, et al. Novel screening method for potential skin-whitening compounds by a luciferase reporter assay. Biosci Biotechnol Biochem. 2010;74:2253-8 pubmed
    ..These results indicate this new luciferase reported assay system to be an effective and convenient method for screening potential skin-whitening compounds. ..
  2. Kawano M, Matsuyama K, Miyamae Y, Shinmoto H, Kchouk M, Morio T, et al. Antimelanogenesis effect of Tunisian herb Thymelaea hirsuta extract on B16 murine melanoma cells. Exp Dermatol. 2007;16:977-84 pubmed
    ..This indicates that our findings might be attributable to daphnanes...
  3. Chao H, Najjaa H, Villareal M, Ksouri R, Han J, Neffati M, et al. Arthrophytum scoparium inhibits melanogenesis through the down-regulation of tyrosinase and melanogenic gene expressions in B16 melanoma cells. Exp Dermatol. 2013;22:131-6 pubmed publisher
    ..This is the first report on the antimelanogenesis effect of A. scoparium and on its potential as a whitening agent. ..
  4. Yada Y, Higuchi K, Imokawa G. Effects of endothelins on signal transduction and proliferation in human melanocytes. J Biol Chem. 1991;266:18352-7 pubmed
    ..2% bovine pituitary extract, resulting in a 4.5-fold increase in cell number for 12 culture days. These findings strongly suggest involvement of ET in the mechanism regulating proliferation and melanization of human melanocytes. ..
  5. Suzuki H, Furusho Y, Higashi T, Ohnishi Y, Horinouchi S. A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone. J Biol Chem. 2006;281:824-33 pubmed publisher
    ..GriF is thus a novel o-aminophenol oxidase that is responsible for the formation of the phenoxazinone chromophore in the grixazone biosynthetic pathway...
  6. Zhaorigetu S, Yanaka N, Sasaki M, Watanabe H, Kato N. Silk protein, sericin, suppresses DMBA-TPA-induced mouse skin tumorigenesis by reducing oxidative stress, inflammatory responses and endogenous tumor promoter TNF-alpha. Oncol Rep. 2003;10:537-43 pubmed
    ..The results suggest that sericin possesses protective effect against tumor promotion in mouse skin by suppressing oxidative stress, inflammatory responses and TNF-alpha. ..
  7. Yamaki K, Gocho K, Hayakawa K, Kondo I, Sakuragi S. Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease. J Immunol. 2000;165:7323-9 pubmed
    ..We conclude that VKH disease is an autoimmune disease against the tyrosinase family proteins...
  8. Marubashi S, Shimada H, Fukuda M, Ohbayashi N. RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J Biol Chem. 2016;291:1427-40 pubmed publisher
    ..These results collectively indicate that proper spatiotemporal regulation of Rab32/38 is essential for the trafficking of all three melanogenic enzymes in mouse melanocytes. ..
  9. Tomita Y. The molecular genetics of albinism and piebaldism. Arch Dermatol. 1994;130:355-8 pubmed
    ..Piebaldism is an autosomal-dominant congenital leukoderma associated with a white forelock. The molecular pathogeneses of these congenital pigmentary disorders have been clarified in recent years and are briefly reviewed here...
  10. Okumura N, Hayashi T, Sekikawa H, Matsumoto T, Mikawa A, Hamasima N, et al. Sequences and mapping of genes encoding porcine tyrosinase (TYR) and tyrosinase-related proteins (TYRP1 and TYRP2). Anim Genet. 2005;36:513-6 pubmed
  11. Matoba Y, Kihara S, Muraki Y, Bando N, Yoshitsu H, Kuroda T, et al. Activation Mechanism of the Streptomyces Tyrosinase Assisted by the Caddie Protein. Biochemistry. 2017;56:5593-5603 pubmed publisher
    ..Aggregation of the caddie protein, which is triggered by the conversion of the Tyr98 residue to dopaquinone, may ensure the generation of fully activated tyrosinase...
  12. Shigemura T, Shiohara M, Tanaka M, Takeuchi K, Koike K. Effect of the mutant microphthalmia-associated transcription factor found in Tietz syndrome on the in vitro development of mast cells. J Pediatr Hematol Oncol. 2010;32:442-7 pubmed publisher
    ..These findings suggest that MITF does not play a critical role in MC development in humans. ..
  13. Shiohara M, Shigemura T, Suzuki T, Tanaka M, Morii E, Ohtsu H, et al. MITF-CM, a newly identified isoform of microphthalmia-associated transcription factor, is expressed in cultured mast cells. Int J Lab Hematol. 2009;31:215-26 pubmed publisher
    ..In contrast, none of the MITF isoforms transactivated both the tryptase and chymase gene promoters, indicating differences in the gene transactivation system between humans and mice. ..
  14. Kawamura Konishi Y, Tsuji M, Hatana S, Asanuma M, Kakuta D, Kawano T, et al. Purification, characterization, and molecular cloning of tyrosinase from Pholiota nameko. Biosci Biotechnol Biochem. 2007;71:1752-60 pubmed
    ..These results suggest that P. nameko tyrosinase is expressed as a proenzyme followed by specific cleavage to produce a mature enzyme. ..
  15. Inagaki H, Koga A, Bessho Y, Hori H. The tyrosinase gene from medakafish: transgenic expression rescues albino mutation. Pigment Cell Res. 1998;11:283-90 pubmed
    ..Thus, transgenic expression rescued from the albino-i(l) mutation, and the i locus of the medaka genome can be concluded to encode the tyrosinase gene. ..
  16. Inagaki H, Bessho Y, Koga A, Hori H. Expression of the tyrosinase-encoding gene in a colorless melanophore mutant of the medaka fish, Oryzias latipes. Gene. 1994;150:319-24 pubmed
    ..In the b mutant, contrary to expectation, the mRNA was detected not only in eyes but also in amelanotic skin. Therefore, pigmentation of the skin controlled by b is not directly related to expression of the Tyr gene...
  17. Fujimoto K, Okino N, Kawabata S, Iwanaga S, Ohnishi E. Nucleotide sequence of the cDNA encoding the proenzyme of phenol oxidase A1 of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1995;92:7769-73 pubmed
    ..It seems, therefore, likely that pro-PO originates from a common ancestor with arthropod hemocyanins, independently to the vertebrate and microbial tyrosinases. ..