Genomes and Genes
Experts and Doctors on molecular sequence data in United States
Locale: United States
Topic: molecular sequence data
Publications955 found, 100 shown here
- Dai G, Liu B, Szpirer C, Levan G, Kwok S, Soares M. Prolactin-like protein-C variant: complementary deoxyribonucleic acid, unique six exon gene structure, and trophoblast cell-specific expression. Endocrinology. 1996;137:5009-19 pubmed..In conclusion, we have identified a new member of the PRL family possessing considerable homology to PLP-C, a unique gene structure, and displaying a trophoblast-specific pattern of transcriptional activation. ..
- Papenbrock T, Peterson R, Lee R, Hsu T, Kuroiwa A, Awgulewitsch A. Murine Hoxc-9 gene contains a structurally and functionally conserved enhancer. Dev Dyn. 1998;212:540-7 pubmed..This finding indicates that the Hoxc-9 intragenic enhancer is involved in transcriptional regulatory circuits conserved between vertebrates and arthropods. ..
- Peck R, DasSarma S, Krebs M. Homologous gene knockout in the archaeon Halobacterium salinarum with ura3 as a counterselectable marker. Mol Microbiol. 2000;35:667-76 pubmed..These studies establish an efficient new genetic strategy towards the systematic knockout of genes in an archaeon. ..
- Chiu C, Ross L, Cohen B, Lester H, Gill S. The transporter-like protein inebriated mediates hyperosmotic stimuli through intracellular signaling. J Exp Biol. 2000;203:3531-46 pubmed..We propose that stimulation of MasIne releases intracellular Ca(2+) in native tissues, activating Ca(2+)-dependent K(+) channels, and leading to K(+) transport. ..
- Chapman T, Heikema A, West A, Bjorkman P. Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). Immunity. 2000;13:727-36 pubmed..The LIR-1 binding site comprises a portion of D1 distant from the interdomain hinge region that constitutes the KIR binding site, consistent with differences in LIR-1 and KIR recognition properties and functions. ..
- Wang T, Lafuse W, Zwilling B. NFkappaB and Sp1 elements are necessary for maximal transcription of toll-like receptor 2 induced by Mycobacterium avium. J Immunol. 2001;167:6924-32 pubmed..Together, these data provide genetic and biochemical evidence for NF-kappaB as well as Sp1 in regulating TLR2 transcription. ..
- Lowther W, Weissbach H, Etienne F, Brot N, Matthews B. The mirrored methionine sulfoxide reductases of Neisseria gonorrhoeae pilB. Nat Struct Biol. 2002;9:348-52 pubmed publisher..These observations have broad implications for modular catalysis, antibiotic drug design and continuing longevity studies in mammals...
- De La Fuente J, Van Den Bussche R, Garcia Garcia J, Rodríguez S, Garcia M, Guglielmone A, et al. Phylogeography of New World isolates of Anaplasma marginale based on major surface protein sequences. Vet Microbiol. 2002;88:275-85 pubmed..marginale isolates. In contrast MSP1a sequences appeared to be rapidly evolving and these sequences may provide phylogeographic information only when numerous isolate MSP1a sequences are analyzed from a geographic area...
- d Offay J, Floyd J, Eberle R, Saliki J, Brock K, D Andrea G, et al. Use of a polymerase chain reaction assay to detect bovine herpesvirus type 2 DNA in skin lesions from cattle suspected to have pseudo-lumpy skin disease. J Am Vet Med Assoc. 2003;222:1404-7, 1366-7 pubmed..Our findings suggest that PLSD may be more common and widespread in the United States than suggested by the frequency with which BHV-2 has been isolated from cattle with PLSD-like skin lesions...
- Rose K, Marin M, Kozak S, Kabat D. Regulated production and anti-HIV type 1 activities of cytidine deaminases APOBEC3B, 3F, and 3G. AIDS Res Hum Retroviruses. 2005;21:611-9 pubmed..Although A3G and/or A3F inactivate HIV-1(Deltavif) and are neutralized by Vif, the antiviral properties of cell lines are also influenced by other cellular and viral factors. ..
- Xu R, Jin J, Hu W, Sun W, Bielawski J, Szulc Z, et al. Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. FASEB J. 2006;20:1813-25 pubmed..Taken together, these results suggest that haCER2 is important for the generation of S1P and S1P-mediated cell proliferation and survival, but that its overexpression may cause cell growth arrest due to an accumulation of sphingosine. ..
- Bochkov Y, Palmenberg A. Translational efficiency of EMCV IRES in bicistronic vectors is dependent upon IRES sequence and gene location. Biotechniques. 2006;41:283-4, 286, 288 passim pubmed..The preferred IRES (viral bases 273-845) and the minimum IRES (viral bases 400-836) for optimum activity are illustrated. ..
- Cornilescu G, Vinarov D, Tyler E, Markley J, Cornilescu C. Solution structure of a single-domain thiosulfate sulfurtransferase from Arabidopsis thaliana. Protein Sci. 2006;15:2836-41 pubmed..Versions of this domain that lack the active site cysteine are found in other proteins, such as phosphatases, ubiquitin hydrolases, and sulfuryltransferases. ..
- Fretz J, Zella L, Kim S, Shevde N, Pike J. 1,25-Dihydroxyvitamin D3 induces expression of the Wnt signaling co-regulator LRP5 via regulatory elements located significantly downstream of the gene's transcriptional start site. J Steroid Biochem Mol Biol. 2007;103:440-5 pubmed..Our studies show that 1,25(OH)(2)D(3) can enhance the expression of a critical component of the Wnt signaling pathway which is known to impact osteogenesis. ..
- Nichols Z, Vogt R. The SNMP/CD36 gene family in Diptera, Hymenoptera and Coleoptera: Drosophila melanogaster, D. pseudoobscura, Anopheles gambiae, Aedes aegypti, Apis mellifera, and Tribolium castaneum. Insect Biochem Mol Biol. 2008;38:398-415 pubmed publisher..The current state of knowledge of the characterized insect members of this gene family is discussed. ..
- Blanchong J, Heisey D, Scribner K, Libants S, Johnson C, Aiken J, et al. Genetic susceptibility to chronic wasting disease in free-ranging white-tailed deer: complement component C1q and Prnp polymorphisms. Infect Genet Evol. 2009;9:1329-35 pubmed publisher..While we documented numerous amino acid polymorphisms in C1q genes none appear to be strongly associated with CWD susceptibility. ..
- Prakasam A, Muthuswamy A, Ablonczy Z, Greig N, Fauq A, Rao K, et al. Differential accumulation of secreted AbetaPP metabolites in ocular fluids. J Alzheimers Dis. 2010;20:1243-53 pubmed publisher..In addition, failure of free clearance from the eye may trigger retina degeneration in a manner similar to Abeta-related neurodegeneration in AD. ..
- Balzli C, Bartell J, Dajcs J, McCormick C, Caballero A, Stroman D, et al. A highly virulent Staphylococcus aureus: rabbit anterior chamber infection, characterization, and genetic analysis. Invest Ophthalmol Vis Sci. 2010;51:5114-20 pubmed publisher..To describe and characterize a Staphylococcus aureus strain with unique virulence that overcomes host defenses of the rabbit anterior chamber and mimics clinical cases of postcataract surgery endophthalmitis...
- Hsueh K, Westler W, Markley J. NMR investigations of the Rieske protein from Thermus thermophilus support a coupled proton and electron transfer mechanism. J Am Chem Soc. 2010;132:7908-18 pubmed publisher..Our results are most consistent with a mechanism involving the coupled transfer of an electron and transfer of the proton across the hydrogen bond between the hydroquinone and His154 at the cytochrome b site...
- Wilson L, Sackett J, Mieczkowski B, Richie A, Thoemke K, Rumbley J, et al. Fertilization in C. elegans requires an intact C-terminal RING finger in sperm protein SPE-42. BMC Dev Biol. 2011;11:10 pubmed publisher..The C-terminal domain swap experiment suggests that the incompatibility between the C. elegans and C. briggsae SPE-42 proteins is caused by small amino acid differences outside the C-terminal domain. ..
- Nemoto M, Wang Q, Li D, Pan S, Matsunaga T, Kisailus D. Proteomic analysis from the mineralized radular teeth of the giant Pacific chiton, Cryptochiton stelleri (Mollusca). Proteomics. 2012;12:2890-4 pubmed publisher..Our results indicate that several proteins were dominant in the mineralized part of the radular teeth, amongst which, myoglobin and a highly acidic peptide were identified as possibly involved in the biomineralization process...
- Thekke Veetil T, Aboughanem Sabanadzovic N, Keller K, Martin R, Sabanadzovic S, Tzanetakis I. Molecular characterization and population structure of blackberry vein banding associated virus, new Ampelovirus associated with yellow vein disease. Virus Res. 2013;178:234-40 pubmed publisher..Further analyses indicated that these proteins are under stringent purifying selections. High genetic variability and incongruent clustering of isolates suggested the possible involvement of recombination in the evolution of BVBaV. ..
- Li D, Cottrell C, Cowan J. 15N resonance assignments of oxidized and reduced Chromatium vinosum high-potential iron protein. J Protein Chem. 1995;14:115-26 pubmed..HMQC-COSY, and HMQC-NOESY spectra. Unambiguous assignment of 70 of 85 backbone 15N resonances in the reduced protein and 62 of 85 resonances in the oxidized protein are made, as are 12 of 21 side-chain 15N resonances. ..
- Smilinich N, Day C, Fitzpatrick G, Caldwell G, Lossie A, Cooper P, et al. A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome. Proc Natl Acad Sci U S A. 1999;96:8064-9 pubmed..We propose that KvDMR1 and/or its associated antisense RNA (KvLQT1-AS) represents an additional imprinting control element or center in the human 11p15.5 and mouse distal 7 imprinted domains. ..
- Hamza I, Hassett R, O Brian M. Identification of a functional fur gene in Bradyrhizobium japonicum. J Bacteriol. 1999;181:5843-6 pubmed..The B. japonicum Fur bound to a Fur box DNA element in vitro, and a fur mutant grown in iron-replete medium was derepressed for iron uptake activity. Thus, B. japonicum expresses at least two regulators of iron metabolism...
- Kumagai A, Dunphy W. Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1. Nat Cell Biol. 2003;5:161-5 pubmed..Our results indicate that two phosphopeptide motifs in Claspin are essential for checkpoint signalling. ..
- Hall A. Differential expression of thymosin genes in human tumors and in the developing human kidney. Int J Cancer. 1991;48:672-7 pubmed
- Thomas C, Dunn M, Mattera R. Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways. Biochem J. 1995;312 ( Pt 1):151-8 pubmed..We have thus identified Ca(2+)-mobilizing agonists and related G-proteins in K562 cells, together with changes induced by DMSO in this signalling pathway. ..
- Brandt U, Uribe S, Schagger H, Trumpower B. Isolation and characterization of QCR10, the nuclear gene encoding the 8.5-kDa subunit 10 of the Saccharomyces cerevisiae cytochrome bc1 complex. J Biol Chem. 1994;269:12947-53 pubmed..We conclude that the 8.5-kDa protein encoded by QCR10 is a subunit of the yeast cytochrome bc1 complex and that the presence of this subunit during assembly is required for stable association of the iron-sulfur protein with the complex. ..
- Tang C, Capaldi R. Characterization of the interface between gamma and epsilon subunits of Escherichia coli F1-ATPase. J Biol Chem. 1996;271:3018-24 pubmed..0 still binds purified epsilon subunit, while enzyme treated with the protease at pH 8.0 does not. This identifies sites around residue 70 and/or between 202 and 212 of the gamma subunit as involved in epsilon subunit binding. ..
- Kusano K, Berres M, Engels W. Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human bloom syndrome gene. Genetics. 1999;151:1027-39 pubmed..We propose that invertebrates such as nematodes and insects are useful as model systems of human genetic diseases. ..
- Jiang H, Kendrick K. Characterization of ssfR and ssgA, two genes involved in sporulation of Streptomyces griseus. J Bacteriol. 2000;182:5521-9 pubmed..The ssfR and ssgA disruption mutants were constructed and showed the "white" mutant phenotype, with some growth medium dependence. In addition, the ssfR null mutant sporulated ectopically in phosphate starvation medium...
- Carlini L, Getz M, Strauch A, Kelm R. Cryptic MCAT enhancer regulation in fibroblasts and smooth muscle cells. Suppression of TEF-1 mediated activation by the single-stranded DNA-binding proteins, Pur alpha, Pur beta, and MSY1. J Biol Chem. 2002;277:8682-92 pubmed
- Tamura G, Nittayajarn A, Schoentag D. A glutamine transport gene, glnQ, is required for fibronectin adherence and virulence of group B streptococci. Infect Immun. 2002;70:2877-85 pubmed..We speculate that glnQ may regulate expression of fibronectin adhesins by affecting cytoplasmic glutamine levels and that regulation may be posttranscriptional...
- Smith L, Smith J. Lack of constitutive activity of the free kinase domain of protein kinase C zeta. Dependence on transphosphorylation of the activation loop. J Biol Chem. 2002;277:45866-73 pubmed..These findings indicate that the catalytic domain of PKC zeta is intrinsically inactive and dependent on the transphosphorylation of the activation loop. ..
- Zhang X, Kim C, Sivakumaran K, Kao C. Stable RNA structures can repress RNA synthesis in vitro by the brome mosaic virus replicase. RNA. 2003;9:555-65 pubmed..The results characterize another potential mechanism whereby the BMV replicase can specifically recognize BMV RNAs...
- Van Lanen S, Reader J, Swairjo M, De Crecy Lagard V, Lee B, Iwata Reuyl D. From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold. Proc Natl Acad Sci U S A. 2005;102:4264-9 pubmed..We report here in vitro and in vivo studies that demonstrate this catalytic activity, as well as preliminary biochemical and bioinformatics analysis that provide insight into the structure of this family of enzymes. ..
- Shin D, Anderson D. Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells. Dev Dyn. 2005;233:1589-604 pubmed..Taken together, these data reveal unanticipated temporal and spatial heterogeneity among arterial endothelial cells of various tissues and organs, raising new questions regarding the functional significance of this diversity. ..
- Nguyen K, Ritz D, Gu J, Alexander D, Chu M, Miao V, et al. Combinatorial biosynthesis of novel antibiotics related to daptomycin. Proc Natl Acad Sci U S A. 2006;103:17462-7 pubmed..This study established a robust combinatorial biosynthesis platform to produce novel peptide antibiotics in sufficient quantities for antimicrobial screening and drug development. ..
- Kendall M, Wardlaw G, Tang C, Bonin A, Liu Y, Valentine D. Diversity of Archaea in marine sediments from Skan Bay, Alaska, including cultivated methanogens, and description of Methanogenium boonei sp. nov. Appl Environ Microbiol. 2007;73:407-14 pubmed..The phylogenetic positions and physiological characteristics of these strains are described. We propose a new species, Methanogenium boonei, with strain AK-7 as the type strain...
- Kim J, Bogner P, Baek S, Ramnath N, Liang P, Kim H, et al. Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target. Clin Cancer Res. 2008;14:2326-33 pubmed publisher..These results suggest that Prx1 may possess unique functions and regulatory mechanisms in NSCLC which are not shared with Prx2, and that Prx1 may serve as a new prognostic biomarker and therapeutic target in NSCLC. ..
- Goffredi S, Jones W, Erhlich H, Springer A, Vrijenhoek R. Epibiotic bacteria associated with the recently discovered Yeti crab, Kiwa hirsuta. Environ Microbiol. 2008;10:2623-34 pubmed publisher..Consequently, the potential for carbon fixation and cycling of reduced and oxidized sulfur appear to exist in the dense microflora that grows on the crab's setae...
- Parker A, Zheng W, Griswold K, Bailey Kellogg C. Optimization algorithms for functional deimmunization of therapeutic proteins. BMC Bioinformatics. 2010;11:180 pubmed publisher..Our mechanism not only helps identify designs more likely to be effective, but also provides insights into the interrelated implications of design choices. ..
- Sizova M, Izquierdo J, Panikov N, Lynd L. Cellulose- and xylan-degrading thermophilic anaerobic bacteria from biocompost. Appl Environ Microbiol. 2011;77:2282-91 pubmed publisher..A mixture of xylan and cellulose was utilized simultaneously, with a significant synergistic effect observed as a reduction of lag phase in cellulose degradation. ..
- Gripp K, Bifeld E, Stabley D, Hopkins E, Meien S, Vinette K, et al. A novel HRAS substitution (c.266C>G; p.S89C) resulting in decreased downstream signaling suggests a new dimension of RAS pathway dysregulation in human development. Am J Med Genet A. 2012;158A:2106-18 pubmed publisher..While the pathogenicity of the HRAS c.266C>G change remains unproven, our data may illustrate wide functional and phenotypic variability of germline HRAS mutations. ..
- Gollapudi S, Mamidi R, Mallampalli S, Chandra M. The N-terminal extension of cardiac troponin T stabilizes the blocked state of cardiac thin filament. Biophys J. 2012;103:940-8 pubmed..Our finding has implications regarding the effect of tissue- and disease-related changes in cTnT isoforms on cardiac muscle function. ..
- Lockhart M, Wirrig E, Phelps A, Ghatnekar A, Barth J, Norris R, et al. Mef2c regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart. PLoS ONE. 2013;8:e57073 pubmed publisher..Combined, these findings highlight a new role for Mef2c in cardiac development and the regulation of cardiac extracellular matrix protein expression. ..
- Zhang F, Fu L, Wang Y. 6-thioguanine induces mitochondrial dysfunction and oxidative DNA damage in acute lymphoblastic leukemia cells. Mol Cell Proteomics. 2013;12:3803-11 pubmed publisher..Together, our results suggested that (S)G may exert its cytotoxic effect by inducing mitochondrial dysfunction and reactive oxygen species formation in acute lymphoblastic leukemia cells. ..
- Hong W, Doyle D. Molecular dissection of the NH2-terminal signal/anchor sequence of rat dipeptidyl peptidase IV. J Cell Biol. 1990;111:323-8 pubmed..These and other structural features of the DPPIV amino-terminal signal-anchor sequences are discussed along with other types of sequences for their role in targeting nascent polypeptides to the RER. ..
- Nicholson B, Dermietzel R, Teplow D, Traub O, Willecke K, Revel J. Two homologous protein components of hepatic gap junctions. Nature. 1987;329:732-4 pubmed..Thus, it seems that hepatic gap junction channels (and by extension possibly others) are composed of two (or more) homologous proteins. ..
- Lee I, Aukerman M, Gore S, Lohman K, Michaels S, Weaver L, et al. Isolation of LUMINIDEPENDENS: a gene involved in the control of flowering time in Arabidopsis. Plant Cell. 1994;6:75-83 pubmed..Genomic and cDNA clones of the LD gene were characterized. The predicted amino acid sequence of the LD protein contains 953 residues and includes two putative bipartite nuclear localization signals and a glutamine-rich region. ..
- Langemeier J, Cook S, Cook R, Rushlow K, Montelaro R, Issel C. Detection of equine infectious anemia viral RNA in plasma samples from recently infected and long-term inapparent carrier animals by PCR. J Clin Microbiol. 1996;34:1481-7 pubmed..Viral gag sequences were not detectable in this control group. These data suggest that the EIAV RT-nPCR assay effectively detects EIAV and is more sensitive than current standard methods for detection of early stages of infection...
- McNicholas P, Salavati R, Oliver D. Dual regulation of Escherichia coli secA translation by distinct upstream elements. J Mol Biol. 1997;265:128-41 pubmed..Our results suggest strongly that there is a system of dual regulation of secA translation, whereby helix I serves as an activator element while helix II serves as a repressor element. ..
- Takaki S, Watts J, Forbush K, Nguyen N, Hayashi J, Alberola Ila J, et al. Characterization of Lnk. An adaptor protein expressed in lymphocytes. J Biol Chem. 1997;272:14562-70 pubmed..Together these studies suggest that Lnk participates in signaling from receptors other than antigen receptors in lymphocytes. ..
- Laughner B, Sehnke P, Ferl R. A novel nuclear member of the thioredoxin superfamily. Plant Physiol. 1998;118:987-96 pubmed
- Smart L, Cameron K, Bennett A. Isolation of genes predominantly expressed in guard cells and epidermal cells of Nicotiana glauca. Plant Mol Biol. 2000;42:857-69 pubmed..This work has identified members of a subset of epidermis- and guard cell-predominant genes, whose protein products are likely to contribute to the unique properties acquired by guard cells and pavement cells during differentiation. ..
- Havlicek V, Higgins L, Chen W, Halada P, Sebo P, Sakamoto H, et al. Mass spectrometric analysis of recombinant adenylate cyclase toxin from Bordetella pertussis strain 18323/pHSP9. J Mass Spectrom. 2001;36:384-91 pubmed
- Hurwitz A, Sullivan T, Sobel R, Allison J. Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice. Proc Natl Acad Sci U S A. 2002;99:3013-7 pubmed
- Harpel M, Horiuchi K, Luo Y, Shen L, Jiang W, Nelson D, et al. Mutagenesis and mechanism-based inhibition of Streptococcus pyogenes Glu-tRNAGln amidotransferase implicate a serine-based glutaminase site. Biochemistry. 2002;41:6398-407 pubmed
- Li M, Wang Y, Yu Y, Nishizawa M, Nakajima T, Ito S, et al. The human transcription factor activation protein-2 gamma (AP-2gamma): gene structure, promoter, and expression in mammary carcinoma cell lines. Gene. 2002;301:43-51 pubmed..hAP-2alpha and hAP-2gamma have some common and some distinct roles in cells, and are likely the remarkable results of gene duplication, translocation and functional divergence through evolution. ..
- Nikiforov M, Popov N, Kotenko I, Henriksson M, Cole M. The Mad and Myc basic domains are functionally equivalent. J Biol Chem. 2003;278:11094-9 pubmed..We find that the wild-type c-Myc and c-Myc/MadBR proteins have indistinguishable biological activity and target gene recognition in vivo. These data are consistent with a model in which Myc and Mad regulate a common set of target genes. ..
- Daido H, Zhou M, Gomez Sanchez E, Gomez Sanchez C. Interferon-inducible genes in the rat adrenal gland and vascular smooth muscle cells. Mol Cell Endocrinol. 2003;200:81-7 pubmed..These results show that genes similar to the human 1-8 gene family are expressed in rat adrenal glomerulosa cells and VSMC, but their expression is not regulated by A-II. The function of these genes in VSMC and adrenal is unknown. ..
- Aminev A, Amineva S, Palmenberg A. Encephalomyocarditis viral protein 2A localizes to nucleoli and inhibits cap-dependent mRNA translation. Virus Res. 2003;95:45-57 pubmed
- Abdu U, González Reyes A, Ghabrial A, Schupbach T. The Drosophila spn-D gene encodes a RAD51C-like protein that is required exclusively during meiosis. Genetics. 2003;165:197-204 pubmed..As there is no apparent ortholog of the meiosis-specific DMC1 gene in the Drosophila genome, and given their meiosis-specific requirement, we suggest that spn-B and spn-D may have a function comparable to DMC1. ..
- Dharmasiri N, Dharmasiri S, Estelle M. The F-box protein TIR1 is an auxin receptor. Nature. 2005;435:441-5 pubmed..Finally, TIR1 synthesized in insect cells binds Aux/IAA proteins in an auxin-dependent manner. Together, these results indicate that TIR1 is an auxin receptor that mediates Aux/IAA degradation and auxin-regulated transcription. ..
- Elango V, Liggenstoffer A, Fathepure B. Biodegradation of vinyl chloride and cis-dichloroethene by a Ralstonia sp. strain TRW-1. Appl Microbiol Biotechnol. 2006;72:1270-5 pubmed..This ability of the strain TRW-1 to degrade cis-DCE in the presence of a nontoxic, water-soluble substrate is relevant to in-situ remediation of cis-DCE-contaminated aquifers...
- McBride K, Riley M, Zender G, Fitzgerald Butt S, Towbin J, Belmont J, et al. NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling. Hum Mol Genet. 2008;17:2886-93 pubmed publisher..These results also establish for the first time that AVS, COA and HLHS can share a common pathogenetic mechanism at the molecular level, explaining observations of these defects co-occurring within families. ..
- Hohle T, O Brian M. The mntH gene encodes the major Mn(2+) transporter in Bradyrhizobium japonicum and is regulated by manganese via the Fur protein. Mol Microbiol. 2009;72:399-409 pubmed publisher..japonicum, and show that Fur is a manganese-responsive regulator in that organism. Furthermore, Fe(2+) is neither a substrate for MntH nor a regulator of mntH expression in vivo...
- Hall J, Karplus P, Barbar E. Multivalency in the assembly of intrinsically disordered Dynein intermediate chain. J Biol Chem. 2009;284:33115-21 pubmed publisher..Our results show assembled dynein IC as an elongated, flexible polybivalent duplex, and suggest that polybivalency is an important general mechanism for constructing stable yet reversible and functionally versatile complexes. ..
- Wisser R, Kolkman J, Patzoldt M, Holland J, Yu J, Krakowsky M, et al. Multivariate analysis of maize disease resistances suggests a pleiotropic genetic basis and implicates a GST gene. Proc Natl Acad Sci U S A. 2011;108:7339-44 pubmed publisher..The known functions of GSTs suggested that variability in detoxification pathways underlie natural variation in maize MDR...
- Schetelig M, Nirmala X, Handler A. Pro-apoptotic cell death genes, hid and reaper, from the tephritid pest species, Anastrepha suspensa. Apoptosis. 2011;16:759-68 pubmed publisher..We show that these tephritid cell death genes are functional and potent as cell death effectors, and could be used to design improved transgenic lethality systems for insect population control. ..
- Suttangkakul A, Li F, Chung T, Vierstra R. The ATG1/ATG13 protein kinase complex is both a regulator and a target of autophagic recycling in Arabidopsis. Plant Cell. 2011;23:3761-79 pubmed publisher..Given its responsiveness to nutrient demands, the turnover of the ATG1/13 kinase likely provides a dynamic mechanism to tightly connect autophagy to a plant's nutritional status. ..
- Kamlekar R, Simanshu D, Gao Y, Kenoth R, Pike H, Prendergast F, et al. The glycolipid transfer protein (GLTP) domain of phosphoinositol 4-phosphate adaptor protein-2 (FAPP2): structure drives preference for simple neutral glycosphingolipids. Biochim Biophys Acta. 2013;1831:417-27 pubmed publisher..These findings along with the distinct mRNA exon/intron organizations originating from single-copy genes on separate human chromosomes suggest adaptive evolutionary divergence by these two GLTP-folds. ..
- Al Khedery B, Lundgren A, Stuen S, Granquist E, Munderloh U, Nelson C, et al. Structure of the type IV secretion system in different strains of Anaplasma phagocytophilum. BMC Genomics. 2012;13:678 pubmed publisher..These data suggest that the T4SS should be investigated further for a potential role in strain virulence of A. phagocytophilum. ..
- Powers P, Liu S, Hogan K, Gregg R. Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene. J Biol Chem. 1992;267:22967-72 pubmed..Transcripts from the beta 1 gene were detected in RNA from skeletal muscle, heart, spleen, and brain, but not in RNA from liver, stomach, or kidney. ..
- Demarini D, Papa F, Swaminathan S, Ursic D, Rasmussen T, Culbertson M, et al. The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo. Mol Cell Biol. 1995;15:6311-21 pubmed
- Lee S, Nicholls R, Jong M, Fukai K, Spritz R. Organization and sequence of the human P gene and identification of a new family of transport proteins. Genomics. 1995;26:354-63 pubmed..These results provide the basis for analyses of patients with OCA2 and may point toward eventual pharmacologic treatment of this and related disorders of pigmentation...
- Shahrestanifar M, Saha D, Scala L, Basu A, Howells R. Cloning of a human cDNA encoding a putative nucleotide-binding protein related to Escherichia coli MinD. Gene. 1994;147:281-5 pubmed..NBP and MinD contain consensus nucleotide (nt)-binding domains. The NBP mRNA is approx. 1500 nt in length and is expressed in several human cell lines and in all rat tissues examined, with the highest levels in lung and testis. ..
- Dickeson S, Helmkamp G, Yarbrough L. Sequence of a human cDNA encoding phosphatidylinositol transfer protein and occurrence of a related sequence in widely divergent eukaryotes. Gene. 1994;142:301-5 pubmed..A comparison of rat and human PtdInsTP cDNAs revealed strong sequence similarity (88 and 84%) in portions of the corresponding 5'- and 3'-untranslated regions (UTR) of the rat and human mRNAs. ..
- Sherman M, Dube S, Spicer T, Kane T, Love J, Saksena N, et al. Sequence analysis of an immunogenic and neutralizing domain of the human T-cell lymphoma/leukemia virus type I gp46 surface membrane protein among various primate T-cell lymphoma/leukemia virus isolates including those from a patient with both HTLV-I. Cancer Res. 1993;53:6067-73 pubmed..No consistent disease-related changes were observed.(ABSTRACT TRUNCATED AT 400 WORDS)..
- Jones D, Isfort R, Witter R, Kost R, Kung H. Retroviral insertions into a herpesvirus are clustered at the junctions of the short repeat and short unique sequences. Proc Natl Acad Sci U S A. 1993;90:3855-9 pubmed..This clustering of insertions presumably is influenced by selection for viable and fast-growing viruses, and occurs in a region of the MDV genome which shows significant size heterogeneity in several strains. ..
- Chai X, Zhai Y, Napoli J. Cloning of a rat cDNA encoding retinol dehydrogenase isozyme type III. Gene. 1996;169:219-22 pubmed..These data extend the insight that a subfamily of SDR isozymes, tissue-distinctively expressed, catalyzes the first step in RA biogenesis. ..
- Peterson M, POPADIC A, Kaufman T. The expression of two engrailed-related genes in an apterygote insect and a phylogenetic analysis of insect engrailed-related genes. Dev Genes Evol. 1998;208:547-57 pubmed..Thermobia engrailed-related expression also confirms that the dorsal ridge is an ancient structure in insects. ..
- Venolia L, Ao W, Kim S, Kim C, Pilgrim D. unc-45 gene of Caenorhabditis elegans encodes a muscle-specific tetratricopeptide repeat-containing protein. Cell Motil Cytoskeleton. 1999;42:163-77 pubmed
- Sinha S, Abraham S, Gronostajski R, Campbell C. Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2. Gene. 2000;258:15-29 pubmed..These results suggest that the various T-box proteins, while highly conserved, likely use different mechanisms to modulate transcription and may have different targets in vivo. ..