Experts and Doctors on molecular sequence data in United Kingdom

Summary

Locale: United Kingdom
Topic: molecular sequence data

Top Publications

  1. Myat A, Henrique D, Ish Horowicz D, Lewis J. A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis. Dev Biol. 1996;174:233-47 pubmed
    ..We argue that signalling via Notch maintains neurogenesis, both in vertebrates and in flies, by keeping a proportion of the neuroepithelial cells in an uncommitted stem-cell-like state. ..
  2. Simpson C, Russell R. Identification of a homolog of CcpA catabolite repressor protein in Streptococcus mutans. Infect Immun. 1998;66:2085-92 pubmed
    ..These results suggest that while RegM can affect catabolite repression in S. mutans, it does not conform to the model proposed for CcpA in Bacillus subtilis. ..
  3. Michaelson L, Lazarus C, Griffiths G, Napier J, Stobart A. Isolation of a Delta5-fatty acid desaturase gene from Mortierella alpina. J Biol Chem. 1998;273:19055-9 pubmed
    ..The M. alpina Delta5-desaturase is the first example of a cloned Delta5-desaturase, and differs from other fungal desaturases previously characterized by the presence of an N-terminal domain related to cytochrome b5. ..
  4. Pike A, Brzozowski A, Roberts S, Olsen O, Persson E. Structure of human factor VIIa and its implications for the triggering of blood coagulation. Proc Natl Acad Sci U S A. 1999;96:8925-30 pubmed
    ..This subtle structural difference sheds light on the mechanism of the dramatic tissue factor-induced enhancement of factor VIIa activity. ..
  5. Fullwood Y, dos Santos M, Hsuan J. Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta. J Biol Chem. 1999;274:31553-8 pubmed
  6. Hallet B, Arciszewska L, Sherratt D. Reciprocal control of catalysis by the tyrosine recombinases XerC and XerD: an enzymatic switch in site-specific recombination. Mol Cell. 1999;4:949-59 pubmed
  7. Goulding S, zur Lage P, Jarman A. amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge. Neuron. 2000;25:69-78 pubmed
    ..We present evidence that amos is required for olfactory sensilla and is regulated by the prepattern gene lozenge. Between them, amos, atonal, and the AS-C can potentially account for the origin of the entire PNS. ..
  8. David Cordonnier M, Laval J, O NEILL P. Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins. J Biol Chem. 2000;275:11865-73 pubmed
    ..Therefore, this large inhibition of the excision of DHT by the presence of an opposite AP site may minimize the formation of double-strand breaks in the processing of DNA clustered damages. ..
  9. McKie A, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell. 2000;5:299-309 pubmed
    ..IREG1 stimulates iron efflux following expression in Xenopus oocytes. We conclude that IREG1 represents the long-sought duodenal iron export protein and is upregulated in the iron overload disease, hereditary hemochromatosis. ..

More Information

Publications409 found, 100 shown here

  1. Aranda A, Proudfoot N. Transcriptional termination factors for RNA polymerase II in yeast. Mol Cell. 2001;7:1003-11 pubmed
    ..Deletion of res2 in both fission and budding yeast results in a defect in 3' end formation. This raises the possibility that RNAP II transcriptional termination may in some situations be integrated with cell cycle events. ..
  2. Roberts G, Grogan G, Greter A, Flitsch S, Turner N. Identification of a new class of cytochrome P450 from a Rhodococcus sp. J Bacteriol. 2002;184:3898-908 pubmed
    ..This unprecedented finding leads us to propose that P450RhF represents the first example of a new class of cytochromes P450 in which the reducing equivalents are supplied by a novel reductase in a fused arrangement. ..
  3. Berwick D, Hers I, Heesom K, Moule S, Tavare J. The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes. J Biol Chem. 2002;277:33895-900 pubmed
    ..Taken together, these results demonstrate that serine 454 of ATP-citrate lyase is a novel and major in vivo substrate for protein kinase B. ..
  4. Roes J, Choi B, Power D, Xu P, Segal A. Granulocyte function in grancalcin-deficient mice. Mol Cell Biol. 2003;23:826-30 pubmed
  5. Hanna S, Kirk P, Holt O, Puklavec M, Brown M, Barclay A. A novel form of the membrane protein CD147 that contains an extra Ig-like domain and interacts homophilically. BMC Biochem. 2003;4:17 pubmed
  6. Muskett F, May F, Westley B, Feeney J. Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins. Biochemistry. 2003;42:15139-47 pubmed
    ..Such differences have significant implications for the mechanism of action and functional specificity for the TFF class of proteins. ..
  7. Munro C, Bates S, Buurman E, Hughes H, MacCallum D, Bertram G, et al. Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence. J Biol Chem. 2005;280:1051-60 pubmed
    ..The double mutant was attenuated in virulence, underlining the importance of O-glycosylation in pathogenesis of C. albicans infections. ..
  8. Messenger N, Kabitschke C, Andrews R, Grimmer D, Nunez Miguel R, Blundell T, et al. Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1. Dev Cell. 2005;8:599-610 pubmed
    ..These findings suggest a mechanism by which individual T-domain proteins may interact with different partners to elicit a specific response. ..
  9. Jiggins F, Tinsley M. An ancient mitochondrial polymorphism in Adalis bipunctata linked to a sex-ratio-distorting bacterium. Genetics. 2005;171:1115-24 pubmed
    ..We conclude that the fitness of these male killers may be negatively frequency dependent or different strains may be favored in different populations. These hypotheses await experimental confirmation. ..
  10. Allen J, Harvat E, Stevens J, Ferguson S. A variant System I for cytochrome c biogenesis in archaea and some bacteria has a novel CcmE and no CcmH. FEBS Lett. 2006;580:4827-34 pubmed
    ..Significantly, CcmH is absent from all of the complete archaeal genomes we have studied, and also from most of the bacterial genomes that have CxxxY-type CcmE. ..
  11. Markovic D, Lehnert H, Levine M, Grammatopoulos D. Structural determinants critical for localization and signaling within the seventh transmembrane domain of the type 1 corticotropin releasing hormone receptor: lessons from the receptor variant R1d. Mol Endocrinol. 2008;22:2505-19 pubmed publisher
    ..This mechanism appears to involve accelerated CRH-R2beta endocytosis. ..
  12. Uitte de Willige S, Standeven K, Philippou H, Ariens R. The pleiotropic role of the fibrinogen gamma' chain in hemostasis. Blood. 2009;114:3994-4001 pubmed publisher
    ..This review summarizes the key biologic aspects of this interesting variant of fibrinogen and discusses inconsistencies in current reports. ..
  13. Howie D, Nolan K, Daley S, Butterfield E, Adams E, Garcia Rueda H, et al. MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation. J Immunol. 2009;183:4197-204 pubmed publisher
  14. Nistala K, Adams S, Cambrook H, Ursu S, Olivito B, de Jager W, et al. Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment. Proc Natl Acad Sci U S A. 2010;107:14751-6 pubmed publisher
    ..Therefore therapies targeting the induction of Th17 cells could also attenuate Th17/1 and Th1 effector populations within the inflamed joint. ..
  15. Seipke R, Crossman L, Drou N, Heavens D, Bibb M, Caccamo M, et al. Draft genome sequence of Streptomyces strain S4, a symbiont of the leaf-cutting ant Acromyrmex octospinosus. J Bacteriol. 2011;193:4270-1 pubmed publisher
    ..and other actinomycetes in order to help defend their fungal gardens from parasitic fungi. Herein, we report the draft genome sequence of Streptomyces strain S4, an antifungal-producing symbiont of A. octospinosus. ..
  16. Corvetta D, Chayka O, Gherardi S, D Acunto C, Cantilena S, Valli E, et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem. 2013;288:8332-41 pubmed publisher
    ..Our study implies that MYC tumorigenesis can be effectively antagonized by epigenetic drugs that interfere with the recruitment of chromatin modifiers at repressive E boxes of tumor suppressor genes such as CLU. ..
  17. Balasuriya D, Goetze T, Barrera N, Stewart A, Suzuki Y, Edwardson J. ?-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors adopt different subunit arrangements. J Biol Chem. 2013;288:21987-98 pubmed publisher
    ..We conclude that the two types of ionotropic glutamate receptor are built in different ways from their constituent subunits. This surprising finding necessitates a reassessment of the assembly of these important receptors. ..
  18. Purdue P, Lumb M, Fox M, Griffo G, Hamon Benais C, Povey S, et al. Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase. Genomics. 1991;10:34-42 pubmed
    ..The gene symbol AGXT has been assigned for this locus. ..
  19. Andrews S, Le Brun N, Barynin V, Thomson A, Moore G, Guest J, et al. Site-directed replacement of the coaxial heme ligands of bacterioferritin generates heme-free variants. J Biol Chem. 1995;270:23268-74 pubmed
    ..This study is consistent with the reported location of the BFR heme site at the 2-fold axis and shows that heme is unnecessary for BFR assembly and iron uptake. ..
  20. Aguado B, Campbell R. The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein. Genomics. 1995;25:650-9 pubmed
  21. Williams R, Rhodius V, Bell A, Kolb A, Busby S. Orientation of functional activating regions in the Escherichia coli CRP protein during transcription activation at class II promoters. Nucleic Acids Res. 1996;24:1112-8 pubmed
    ..Using the method of 'oriented heterodimers' we show that these alternative activating regions are functional in the downstream subunit of the bound CRP dimer. ..
  22. Atkin J, Pleass R, Owens R, Woof J. Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly. J Immunol. 1996;157:156-9 pubmed
    ..The tailpiece may thus play some role in promoting the association of alpha-chains required for IgA monomer assembly. ..
  23. Beesley A, Ortega B, White S. Splicing of a retained intron within ROMK K+ channel RNA generates a novel set of isoforms in rat kidney. Am J Physiol. 1999;276:C585-92 pubmed
    ..The deletion in this core region is predicted to generate hydrophilic proteins that are approximately one-third of the size of native ROMK and lack membrane-spanning domains. ..
  24. Brewer A, Gove C, Davies A, McNulty C, Barrow D, Koutsourakis M, et al. The human and mouse GATA-6 genes utilize two promoters and two initiation codons. J Biol Chem. 1999;274:38004-16 pubmed
    ..Thus, GATA-6 function in the cell is controlled by a complex interplay of transcriptional and translational regulation. ..
  25. Wroe S, Kelsey G, Skinner J, Bodle D, Ball S, Beechey C, et al. An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus. Proc Natl Acad Sci U S A. 2000;97:3342-6 pubmed
    ..We propose that Nespas is an additional control element in the imprinting region of mouse distal Chr 2; it adds further complexity to the Gnas-imprinted gene cluster. ..
  26. Saunders K, Bedford I, Briddon R, Markham P, Wong S, Stanley J. A unique virus complex causes Ageratum yellow vein disease. Proc Natl Acad Sci U S A. 2000;97:6890-5 pubmed
    ..conyzoides plays no essential role in the disease and represents a satellite-like DNA. Furthermore, the satellite DNA previously found associated with tomato leaf curl virus is probably a defective DNA beta homologue...
  27. Hall D, Bond C, Leonard G, Watt C, Berry A, Hunter W. Structure of tagatose-1,6-bisphosphate aldolase. Insight into chiral discrimination, mechanism, and specificity of class II aldolases. J Biol Chem. 2002;277:22018-24 pubmed publisher
    ..The availability of more space and a wider range of aldehyde partners used by TBPA together with the highly specific nature of FBPA suggest that TBPA might be a preferred enzyme to modify for use in biotransformation chemistry...
  28. Riffel N, Harlos K, Iourin O, Rao Z, Kingsman A, Stuart D, et al. Atomic resolution structure of Moloney murine leukemia virus matrix protein and its relationship to other retroviral matrix proteins. Structure. 2002;10:1627-36 pubmed
    ..The protein fold appears to be maintained, in part, by the conservation of side chain packing, which may provide a useful tool for searching for weak distant similarities in proteins. ..
  29. Essa A, Julian D, Kidd S, Brown N, Hobman J. Mercury resistance determinants related to Tn21, Tn1696, and Tn5053 in enterobacteria from the preantibiotic era. Antimicrob Agents Chemother. 2003;47:1115-9 pubmed
    ..Tn5073 is most closely related to Tn5036 and Tn1696, and Tn5074 is most closely related to Tn5053. Tn5075 is most closely related to Tn21 but lacks integron In2 and is flanked by insertion elements...
  30. Escobar N, Haupt S, Thow G, Boevink P, Chapman S, Oparka K. High-throughput viral expression of cDNA-green fluorescent protein fusions reveals novel subcellular addresses and identifies unique proteins that interact with plasmodesmata. Plant Cell. 2003;15:1507-23 pubmed
    ..This virus-based system represents a method for high-throughput functional genomic study of plant cell organelles and allows the identification of unique proteins that associate with specific subcompartments within organelles...
  31. Maple J, Fujiwara M, Kitahata N, Lawson T, Baker N, Yoshida S, et al. GIANT CHLOROPLAST 1 is essential for correct plastid division in Arabidopsis. Curr Biol. 2004;14:776-81 pubmed
  32. Holbourn K, Sutton J, Evans H, Shone C, Acharya K. Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase. Proc Natl Acad Sci U S A. 2005;102:5357-62 pubmed
    ..The structure also suggests a molecular explanation for the different levels of C3-exoenzyme inhibition by RalA and why RhoA does not bind C3bot1 in this manner...
  33. Gan Y, Kumimoto R, Liu C, Ratcliffe O, Yu H, Broun P. GLABROUS INFLORESCENCE STEMS modulates the regulation by gibberellins of epidermal differentiation and shoot maturation in Arabidopsis. Plant Cell. 2006;18:1383-95 pubmed
    ..The discovery of GIS reveals a novel mechanism in the control of shoot maturation, through which GAs regulate cellular differentiation in plants. ..
  34. Capasso M, Durrant L, Stacey M, Gordon S, Ramage J, Spendlove I. Costimulation via CD55 on human CD4+ T cells mediated by CD97. J Immunol. 2006;177:1070-7 pubmed
    ..Our results support a multifaceted role for CD55 in human T cell activation, constituting a further link between innate and adaptive immunity. ..
  35. Krysinska H, Hoogenkamp M, Ingram R, Wilson N, Tagoh H, Laslo P, et al. A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene. Mol Cell Biol. 2007;27:878-87 pubmed
    ..The two-step mechanism of developmental gene activation that we describe here may be utilized to regulate gene activity in a variety of developmental pathways. ..
  36. Waterfield N, Sanchez Contreras M, Eleftherianos I, Dowling A, Yang G, Wilkinson P, et al. Rapid Virulence Annotation (RVA): identification of virulence factors using a bacterial genome library and multiple invertebrate hosts. Proc Natl Acad Sci U S A. 2008;105:15967-72 pubmed publisher
    ..The application of RVA to other pathogen genomes promises to ascribe biological function to otherwise uncharacterized virulence genes...
  37. Burge S, Teufel D, Townsley F, Freund S, Bycroft M, Fersht A. Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation. Proc Natl Acad Sci U S A. 2009;106:3142-7 pubmed publisher
    ..Further, we found that phosphorylation of T14 increased the affinity of the p73 N terminus for Taz2 10-fold. The phosphomimetic p73alpha T14D caused increased levels of transactivation. ..
  38. Sauvé V, Roversi P, Leath K, Garman E, Antrobus R, Lea S, et al. Mechanism for the hydrolysis of a sulfur-sulfur bond based on the crystal structure of the thiosulfohydrolase SoxB. J Biol Chem. 2009;284:21707-18 pubmed publisher
    ..5 A. Structures were also determined for SoxB in complex with the substrate analogue thiosulfate and in complex with the product sulfate. A mechanistic model for SoxB is proposed based on these structures. ..
  39. Fogg P, Allison H, Saunders J, McCarthy A. Bacteriophage lambda: a paradigm revisited. J Virol. 2010;84:6876-9 pubmed publisher
    ..coli. Sequence analysis of the complete immunity region demonstrated that these multiply infected lysogens were not immunity mutants. In conclusion, although lambda superinfection immunity can be confounded, it is a rare event...
  40. Saunders D, Breen S, Win J, Schornack S, Hein I, Bozkurt T, et al. Host protein BSL1 associates with Phytophthora infestans RXLR effector AVR2 and the Solanum demissum Immune receptor R2 to mediate disease resistance. Plant Cell. 2012;24:3420-34 pubmed publisher
    ..This reveals that, similar to effectors of phytopathogenic bacteria, recognition of filamentous pathogen effectors can be mediated via a host protein that interacts with both the effector and the NB-LRR immunoreceptor...
  41. Riveron J, Irving H, Ndula M, Barnes K, Ibrahim S, Paine M, et al. Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus. Proc Natl Acad Sci U S A. 2013;110:252-7 pubmed publisher
    ..Urgent resistance management strategies should be implemented in this region to limit a further spread of this resistance and minimize its impact on the success of ongoing malaria control programs. ..
  42. Dou H, Buetow L, Sibbet G, Cameron K, Huang D. Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3. Nat Struct Mol Biol. 2013;20:982-986 pubmed publisher
    ..Hence, interactions outside the canonical RING domain are crucial for optimizing Ub transfer in both monomeric and dimeric RING E3s. We propose that an additional non-RING Ub-priming element may be a common RING E3 feature. ..
  43. Koprivova A, Giovannetti M, Baraniecka P, Lee B, Grondin C, Loudet O, et al. Natural variation in the ATPS1 isoform of ATP sulfurylase contributes to the control of sulfate levels in Arabidopsis. Plant Physiol. 2013;163:1133-41 pubmed publisher
    ..Thus, sulfate content in Arabidopsis is controlled by two genes encoding subsequent enzymes in the sulfate assimilation pathway but using different mechanisms, variation in amino acid sequence and variation in expression levels. ..
  44. Goh S, Hussain H, Chang B, Emmett W, Riley T, Mullany P. Phage ?C2 mediates transduction of Tn6215, encoding erythromycin resistance, between Clostridium difficile strains. MBio. 2013;4:e00840-13 pubmed publisher
    ..This element is 13,008 bp in length and contains 17 putative open reading frames (ORFs). It could also be transferred at a lower frequency by filter mating...
  45. Connelly J, de Leau E, Okely E, Leach D. Overexpression, purification, and characterization of the SbcCD protein from Escherichia coli. J Biol Chem. 1997;272:19819-26 pubmed
    ..We demonstrate that SbcD has the potential to form a secondary structural motif found in a number of protein phosphatases and suggest that it is a metalloprotein that contains the catalytic center of the SbcCD exonuclease. ..
  46. Coleman M, Conforti L, Buckmaster E, Tarlton A, Ewing R, Brown M, et al. An 85-kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse. Proc Natl Acad Sci U S A. 1998;95:9985-90 pubmed
    ..In addition, a duplication allele was identified in two Wlds mice, indicating some instability in the repeat copy number and suggesting that the triplication arose from a duplication by unequal crossing over. ..
  47. Morgan M, Madgwick A. The fourth member of the FHL family of LIM proteins is expressed exclusively in the testis. Biochem Biophys Res Commun. 1999;255:251-5 pubmed
    ..It is suggested that mFHL4 is associated with the process of spermatogenesis. ..
  48. Feinmesser R, Wicks S, Taverner C, Chantry A. Ca2+/calmodulin-dependent kinase II phosphorylates the epidermal growth factor receptor on multiple sites in the cytoplasmic tail and serine 744 within the kinase domain to regulate signal generation. J Biol Chem. 1999;274:16168-73 pubmed
  49. Wallis R, Cheng J. Molecular defects in variant forms of mannose-binding protein associated with immunodeficiency. J Immunol. 1999;163:4953-9 pubmed
  50. Frigerio L, Jolliffe N, Di Cola A, Felipe D, Paris N, Neuhaus J, et al. The internal propeptide of the ricin precursor carries a sequence-specific determinant for vacuolar sorting. Plant Physiol. 2001;126:167-75 pubmed
    ..This is the first reported example of a sequence-specific vacuolar sorting signal located within an internal propeptide. ..
  51. Brown S, Hu N, Hombría J. Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless. Curr Biol. 2001;11:1700-5 pubmed
    ..This suggests that the vertebrate families evolved from a single ancestral receptor that also gave rise to dome. ..
  52. Otero L, Devaux A, Standart N. A 250-nucleotide UA-rich element in the 3' untranslated region of Xenopus laevis Vg1 mRNA represses translation both in vivo and in vitro. RNA. 2001;7:1753-67 pubmed
    ..The abundance of p42, p45, and p60 is strikingly higher in stages I-III than in later stages, consistent with a possible role for these proteins in Vg1 translational control. ..
  53. Edwards A, Vincken J, Suurs L, Visser R, Zeeman S, Smith A, et al. Discrete forms of amylose are synthesized by isoforms of GBSSI in pea. Plant Cell. 2002;14:1767-85 pubmed
    ..The product specificity of GBSSIa could provide beneficial attributes to starches for food and nonfood uses. ..
  54. Rylott E, Rogers C, Gilday A, Edgell T, Larson T, Graham I. Arabidopsis mutants in short- and medium-chain acyl-CoA oxidase activities accumulate acyl-CoAs and reveal that fatty acid beta-oxidation is essential for embryo development. J Biol Chem. 2003;278:21370-7 pubmed
    ..This is the first demonstration of the effects of eliminating (short-chain) beta-oxidation capacity in plants and shows that a functional beta-oxidation cycle is essential in the early stages of embryo development. ..
  55. Murtas G, Reeves P, Fu Y, Bancroft I, Dean C, Coupland G. A nuclear protease required for flowering-time regulation in Arabidopsis reduces the abundance of SMALL UBIQUITIN-RELATED MODIFIER conjugates. Plant Cell. 2003;15:2308-19 pubmed
    ..ESD4 defines an important role for protein modification by AtSUMO in the regulation of flowering. ..
  56. Tzouanacou E, Tweedie S, Wilson V. Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development. Mol Cell Biol. 2003;23:8553-2 pubmed
    ..Database searches identified a family of Jade proteins conserved through vertebrates. This raises the possibility that the absence of phenotype is due to a functional compensation by other family members...
  57. Tan C, Nakielny S. Control of the DNA methylation system component MBD2 by protein arginine methylation. Mol Cell Biol. 2006;26:7224-35 pubmed
    ..It is the first to demonstrate that protein arginine methyltransferases participate in the DNA methylation system of chromatin control. ..
  58. Yu Y, Tangney M, Aass H, Mitchell W. Analysis of the mechanism and regulation of lactose transport and metabolism in Clostridium acetobutylicum ATCC 824. Appl Environ Microbiol. 2007;73:1842-50 pubmed
    ..A pathway for the uptake and metabolism of lactose by this industrially important organism is proposed. ..
  59. Bert A, Johnson B, Baxter E, Cockerill P. A modular enhancer is differentially regulated by GATA and NFAT elements that direct different tissue-specific patterns of nucleosome positioning and inducible chromatin remodeling. Mol Cell Biol. 2007;27:2870-85 pubmed
    ..These studies reveal that distinct tissue-specific mechanisms can be used either alternately or in combination to activate the same enhancer. ..
  60. Catlow K, Ashurst H, Varro A, Dimaline R. Identification of a gastrin response element in the vesicular monoamine transporter type 2 promoter and requirement of 20 S proteasome subunits for transcriptional activity. J Biol Chem. 2007;282:17069-77 pubmed
    ..These data suggest that elements of the 20 S proteasome interact with the VMAT2 promoter to enhance G-protein-coupled receptor-mediated transcription. ..
  61. Bayele H, Peyssonnaux C, Giatromanolaki A, Arrais Silva W, Mohamed H, Collins H, et al. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood. 2007;110:3039-48 pubmed
    ..This report also suggests that microsatellites may play critical roles in the directional evolution of complex heritable traits by regulating gene expression phenotypes. ..
  62. Webster B, Rudolfov J, Hor k P, Littlewood D. The complete mitochondrial genome of the bird schistosome Trichobilharzia regenti (Platyhelminthes: Digenea), causative agent of cercarial dermatitis. J Parasitol. 2007;93:553-61 pubmed publisher
    ..g., T. regenti characterized in this study, but also numerous species within the predominant group of visceral (blood dwelling) bird schistosomes...
  63. Cullen J, Hussey S, Walker C, Prudden J, Wee B, Davé A, et al. Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition. Mol Cell Biol. 2007;27:7745-57 pubmed
    ..Together, these results suggest that the mechanisms of break-induced LOH may be predicted from the functional status of the HR machinery. ..
  64. Hoogenkamp M, Krysinska H, Ingram R, Huang G, Barlow R, Clarke D, et al. The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis. Mol Cell Biol. 2007;27:7425-38 pubmed
    ..Our results provide important insights into how overlapping, but different, sets of transcription factors program tissue-specific chromatin structures in the hematopoietic system. ..
  65. Cooper S, Murawsky C, Lowe N, Travers A. Two modes of degradation of the tramtrack transcription factors by Siah homologues. J Biol Chem. 2008;283:1076-83 pubmed
    ..We speculate that SinaH may be involved in regulating the levels of developmentally important transcription factors. ..
  66. Zhang M, Gaisser S, Nur E Alam M, Sheehan L, Vousden W, Gaitatzis N, et al. Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. J Med Chem. 2008;51:5494-7 pubmed publisher
    ..Structural flexibility may contribute to the preorganization of 5 to exist in solution in the Hsp90-bound conformation. ..
  67. Tambini C, Spink K, Ross C, Hill M, Thacker J. The importance of XRCC2 in RAD51-related DNA damage repair. DNA Repair (Amst). 2010;9:517-25 pubmed publisher
    ..Our data indicate that an important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage. ..
  68. Harvala H, McLeish N, Kondracka J, McIntyre C, McWilliam Leitch E, Templeton K, et al. Comparison of human parechovirus and enterovirus detection frequencies in cerebrospinal fluid samples collected over a 5-year period in edinburgh: HPeV type 3 identified as the most common picornavirus type. J Med Virol. 2011;83:889-96 pubmed publisher
    ..The highly sensitive virus typing methods applied in this study will assist further EV and HPeV screening of sepsis and meningitis cases as well as in future molecular epidemiological studies and population surveillance...
  69. Lum J, Neuweiler H, Fersht A. Long-range modulation of chain motions within the intrinsically disordered transactivation domain of tumor suppressor p53. J Am Chem Soc. 2012;134:1617-22 pubmed publisher
    ..Long-range interactions can be induced in an intrinsically disordered domain by partner proteins that induce apparently only local structure or by post-translational modification. ..
  70. Couto N, Malys N, Gaskell S, Barber J. Partition and turnover of glutathione reductase from Saccharomyces cerevisiae: a proteomic approach. J Proteome Res. 2013;12:2885-94 pubmed publisher
    ..Surprisingly, the second AUG appears to be responsible for most of the cellular Glr1. This is the first report of protein turnover measurements of a low-abundance protein distributed in different compartments of a eukaryotic cell. ..
  71. Feig C, Jones J, Kraman M, Wells R, Deonarine A, Chan D, et al. Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proc Natl Acad Sci U S A. 2013;110:20212-7 pubmed publisher
    ..The residual tumor was composed only of premalignant epithelial cells and inflammatory cells. Thus, a single protein, CXCL12, from a single stromal cell type, the FAP(+) CAF, may direct tumor immune evasion in a model of human PDA. ..
  72. Parker C, Daenke S, Nightingale S, Bangham C. Activated, HTLV-1-specific cytotoxic T-lymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis. Virology. 1992;188:628-36 pubmed
    ..A CTL epitope in the middle region of Tax and one in the C terminus of Pol have been mapped at the peptide level and the HLA Class 1 molecules restricting their recognition have been defined. ..
  73. Willems A, Collins M. Phylogenetic placement of Sarcina ventriculi and Sarcina maxima within group I Clostridium, a possible problem for future revision of the genus Clostridium. Request for an opinion. Int J Syst Bacteriol. 1994;44:591-3 pubmed
    ..The implications of these phylogenetic findings for future revision of the genus Clostridium are discussed...
  74. Bradbury J, Edwards P, Niemeyer C, Dale T. Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice. Dev Biol. 1995;170:553-63 pubmed
    ..As Wnt-1 is not normally expressed in the mammary gland, it may exert its effect on the mammary gland by activating a developmental pathway normally regulated by Wnt-4. ..
  75. Williams J, Morrison A. Prestalk cell-differentiation and movement during the morphogenesis of Dictyostelium discoideum. Prog Nucleic Acid Res Mol Biol. 1994;47:1-27 pubmed
  76. Ponting C, Kerr I. A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues. Protein Sci. 1996;5:914-22 pubmed
    ..It is suggested that, for each of these enzymes, conserved histidine, lysine, aspartic acid, and/or asparagine residues may be involved in a two-step ping pong mechanism involving an enzyme-substrate intermediate. ..
  77. Ji X, Moore H, Russell R, Watts D. cDNA cloning and characterization of a rat spermatogenesis-associated protein RSP29. Biochem Biophys Res Commun. 1997;241:714-9 pubmed
    ..The high expression of RSP29 in testis and its stimulatory effects on Sertoli cells suggest that RSP29 could be especially important in the regulation of spermatogenesis. ..
  78. Pannifer A, Flint A, Tonks N, Barford D. Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography. J Biol Chem. 1998;273:10454-62 pubmed
    ..The hydrolysis of the cysteinyl-phosphate intermediate of PTPs is reminiscent of GTP hydrolysis by the GTPases, in that both families of enzymes utilize an invariant Gln residue to coordinate the attacking nucleophilic water molecule. ..
  79. Prat F, Coward K, Sumpter J, Tyler C. Molecular characterization and expression of two ovarian lipoprotein receptors in the rainbow trout, Oncorhynchus mykiss. Biol Reprod. 1998;58:1146-53 pubmed
    ..The sequence, ovary specificity, and pattern of ovarian expression of the rt-LPR mRNA suggest that it encodes the receptor that mediates vitellogenin uptake into the ovary...
  80. Bemark M, Sale J, Kim H, Berek C, Cosgrove R, Neuberger M. Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity. J Exp Med. 2000;192:1509-14 pubmed
  81. Beales L, Rowlands D, Holzenburg A. The internal ribosome entry site (IRES) of hepatitis C virus visualized by electron microscopy. RNA. 2001;7:661-70 pubmed
    ..Finally, the architecture of the HCV IRES was seen to be markedly different from that of a picornavirus, foot-and-mouth disease virus (FMDV). ..
  82. Murai K, Treisman R. Interaction of serum response factor (SRF) with the Elk-1 B box inhibits RhoA-actin signaling to SRF and potentiates transcriptional activation by Elk-1. Mol Cell Biol. 2002;22:7083-92 pubmed
    ..Combinatorial interactions between SRF and TCF proteins are thus likely to play an important role in determining the relative sensitivity of SRF target genes to Ras- and Rho-controlled signal transduction pathways. ..
  83. Thomson L, Lamont D, Mehlert A, Barry J, Ferguson M. Partial structure of glutamic acid and alanine-rich protein, a major surface glycoprotein of the insect stages of Trypanosoma congolense. J Biol Chem. 2002;277:48899-904 pubmed
    ..Mass spectrometric analyses of tryptic digests suggest that several or all of the closely related glutamic acid and alanine-rich protein genes are expressed simultaneously in a T. congolense population growing in vitro. ..
  84. Dallol A, da Silva N, Viacava P, Minna J, Bieche I, Maher E, et al. SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. Cancer Res. 2002;62:5874-80 pubmed
    ..2. ..
  85. da Silva S, Gates P, Brockes J. The newt ortholog of CD59 is implicated in proximodistal identity during amphibian limb regeneration. Dev Cell. 2002;3:547-55 pubmed
    ..Prod 1 is therefore a cell surface protein implicated in the local cell-cell interactions mediating positional identity...
  86. Miallau L, Alphey M, Kemp L, Leonard G, McSweeney S, Hecht S, et al. Biosynthesis of isoprenoids: crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase. Proc Natl Acad Sci U S A. 2003;100:9173-8 pubmed
    ..Our model therefore provides an accurate template to facilitate the structure-based design of broad-spectrum antimicrobial agents. ..
  87. Krzywda S, Brzozowski A, Higashitsuji H, Fujita J, Welchman R, Dawson S, et al. The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53. J Biol Chem. 2004;279:1541-5 pubmed
    ..Comparison with the structures of other ankyrin repeat proteins suggests that interactions with partner proteins are mediated by residues situated on this concave surface. ..
  88. Hughes Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin S, et al. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell. 2003;115:523-35 pubmed
    ..The remarkable clinical overlap between sporadic EMSY amplification and familial BRCA2 deletion implicates a BRCA2 pathway in sporadic breast and ovarian cancer. ..
  89. Gibson K, Gilleron M, Constant P, Brando T, Puzo G, Besra G, et al. Tsukamurella paurometabola lipoglycan, a new lipoarabinomannan variant with pro-inflammatory activity. J Biol Chem. 2004;279:22973-82 pubmed
    ..This conclusively demonstrates that a linear (alpha1-->6)-Manp chain, linked to the MPI anchor, is sufficient in providing pro-inflammatory activity. ..
  90. Lin H, Chang G, Davies J, Stacey M, Harris J, Gordon S. Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif. J Biol Chem. 2004;279:31823-32 pubmed
  91. Teo H, Perisic O, Gonzalez B, Williams R. ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes. Dev Cell. 2004;7:559-69 pubmed
    ..Vps25 is the chief subunit responsible for Vps20 recruitment. This interaction dramatically increases binding of both components to lipid vesicles in vitro. ..
  92. Gaston Massuet C, Henderson D, Greene N, Copp A. Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system. Dev Dyn. 2005;233:1110-5 pubmed
    ..We conclude that Zic4 has an expression pattern distinct from, but partly overlapping with, other members of the Zic gene family. ..