Genomes and Genes
Experts and Doctors on molecular evolution in Germany
Topic: molecular evolution
Publications229 found, 100 shown here
- Tüncher A, Spröte P, Gehrke A, Brakhage A. The CCAAT-binding complex of eukaryotes: evolution of a second NLS in the HapB subunit of the filamentous fungus Aspergillus nidulans despite functional conservation at the molecular level between yeast, A.nidulans and human. J Mol Biol. 2005;352:517-33 pubmed..nidulans hapB mutant was complemented, at least in part, by both the human NF-YA and S.cerevisiae Hap2p this finding suggests that the piggy-back mechanism of nuclear transport found for A.nidulans is conserved in yeast and human. ..
- Schaschl H, Wegner K. Contrasting mode of evolution between the MHC class I genomic region and class II region in the three-spined stickleback (Gasterosteus aculeatus L.; Gasterosteidae: Teleostei). Immunogenetics. 2007;59:295-304 pubmed..In humans, however, homologues of Oct-2 beta and ATPasealpha3 lie outside the MHC region, which indicates that the concentration of immune genes found in mammalian genomes is a derived state...
- Radzimanowski J, Ravaud S, Schlesinger S, Koch J, Beyreuther K, Sinning I, et al. Crystal structure of the human Fe65-PTB1 domain. J Biol Chem. 2008;283:23113-20 pubmed publisher..We suggest Fe65-PTB1 to interact with its target proteins involved in translocation and signaling of APP in a phosphorylation-dependent manner. ..
- Jekely G. Origin of the nucleus and Ran-dependent transport to safeguard ribosome biogenesis in a chimeric cell. Biol Direct. 2008;3:31 pubmed publisher..This article was reviewed by Eugene V Koonin, Martijn Huynen, Anthony M. Poole and Patrick Forterre. ..
- Völksch B, Thon S, Jacobsen I, Gube M. Polyphasic study of plant- and clinic-associated Pantoea agglomerans strains reveals indistinguishable virulence potential. Infect Genet Evol. 2009;9:1381-91 pubmed publisher..However, these strains were significantly less virulent than a phytopathogenic P. ananatis isolate. We suggest that, independent of their origin, all P. agglomerans strains might possess indistinguishable virulence potential. ..
- Schmickl R, Jørgensen M, Brysting A, Koch M. The evolutionary history of the Arabidopsis lyrata complex: a hybrid in the amphi-Beringian area closes a large distribution gap and builds up a genetic barrier. BMC Evol Biol. 2010;10:98 pubmed publisher..lyrata species complex, we add substantial information to a broad evolutionary framework for future investigations within this emerging model system in molecular and evolutionary biology. ..
- Prawitt D, Enklaar T, Klemm G, Gartner B, Spangenberg C, Winterpacht A, et al. Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression. Hum Mol Genet. 2000;9:203-16 pubmed
- Chakraborty T, Hain T, Domann E. Genome organization and the evolution of the virulence gene locus in Listeria species. Int J Med Microbiol. 2000;290:167-74 pubmed..Thus, here we present an alternative view of the evolution of Listeria spp. and suggest that L. monocytogenes may be the primordial species of this genus. ..
- Greenwood A, Castresana J, Feldmaier Fuchs G, Paabo S. A molecular phylogeny of two extinct sloths. Mol Phylogenet Evol. 2001;18:94-103 pubmed..The results strengthen the view that the two families of living sloths adapted independently to an arboreal life-style...
- Sondermann H, Scheufler C, Schneider C, Hohfeld J, Hartl F, Moarefi I. Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors. Science. 2001;291:1553-7 pubmed..Thus, functional convergence has allowed proteins with different architectures to trigger a conserved conformational shift in Hsp70 that leads to nucleotide exchange. ..
- Grandien K, Sommer R. Functional comparison of the nematode Hox gene lin-39 in C. elegans and P. pacificus reveals evolutionary conservation of protein function despite divergence of primary sequences. Genes Dev. 2001;15:2161-72 pubmed..Therefore, the evolution of lin-39 function is driven by changes in regulatory elements rather than changes in the protein itself. ..
- Sauter C, Basquin J, Suck D. Sm-like proteins in Eubacteria: the crystal structure of the Hfq protein from Escherichia coli. Nucleic Acids Res. 2003;31:4091-8 pubmed..Finally, a detailed structural comparison shows that the Sm-fold is remarkably well conserved in bacteria, Archaea and Eukarya, and represents a universal and modular building unit for oligomeric RNA binding proteins...
- Hoffmeister M, Piotrowski M, Nowitzki U, Martin W. Mitochondrial trans-2-enoyl-CoA reductase of wax ester fermentation from Euglena gracilis defines a new family of enzymes involved in lipid synthesis. J Biol Chem. 2005;280:4329-38 pubmed..Trans-2-enoyl-CoA reductase assigns a biochemical activity, NAD(P)H-dependent acyl-CoA synthesis from enoyl-CoA, to one member of this gene family of previously unknown function...
- Mesecke N, Terziyska N, Kozany C, Baumann F, Neupert W, Hell K, et al. A disulfide relay system in the intermembrane space of mitochondria that mediates protein import. Cell. 2005;121:1059-69 pubmed..We suggest that this process reflects the evolutionary origin of the IMS from the periplasmic space of the prokaryotic ancestors of mitochondria. ..
- Reusch T, Langefors A. Inter- and intralocus recombination drive MHC class IIB gene diversification in a teleost, the three-spined stickleback Gasterosteus aculeatus. J Mol Evol. 2005;61:531-41 pubmed..Our finding of widespread recombination suggests that phylogenies of MHC genes should not be based on coding segments but rather on noncoding introns. ..
- Fuchs C, Luckhardt A, Gerlach F, Burmester T, Hankeln T. Duplicated cytoglobin genes in teleost fishes. Biochem Biophys Res Commun. 2005;337:216-23 pubmed publisher..However, Cygb-2 is more than 250-fold stronger expressed in neuronal tissues, suggesting a subfunctionalization of the two cytoglobin paralogs after gene duplication...
- MacWilliams H, Doquang K, Pedrola R, Dollman G, Grassi D, Peis T, et al. A retinoblastoma ortholog controls stalk/spore preference in Dictyostelium. Development. 2006;133:1287-97 pubmed..rblA-null cells show reduced cell size and a premature growth-development transition; the latter appears anomalous but may reflect selection pressures acting on social ameba. ..
- Kahlau S, Aspinall S, Gray J, Bock R. Sequence of the tomato chloroplast DNA and evolutionary comparison of solanaceous plastid genomes. J Mol Evol. 2006;63:194-207 pubmed publisher..Comparison of the two genotypes (IPA-6, bred in South America, and Ailsa Craig, bred in Europe) revealed no nucleotide differences, suggesting that the plastomes of modern tomato cultivars display very little, if any, sequence variation...
- Isayenkova J, Wray V, Nimtz M, Strack D, Vogt T. Cloning and functional characterisation of two regioselective flavonoid glucosyltransferases from Beta vulgaris. Phytochemistry. 2006;67:1598-612 pubmed..vulgaris tissue culture are discussed as potential endogenous products of UGT73A4 and UGT71F1. The results are analyzed with regard to evolution and specificity of plant natural product glucosyltransferases. ..
- Prüfer K, Muetzel B, Do H, Weiss G, Khaitovich P, Rahm E, et al. FUNC: a package for detecting significant associations between gene sets and ontological annotations. BMC Bioinformatics. 2007;8:41 pubmed..FUNC is a versatile and useful tool for the analysis of genome-wide data. It is freely available under the GPL license and also accessible via a web service. ..
- Mittelstaedt T, Schoch S. Structure and evolution of RIM-BP genes: identification of a novel family member. Gene. 2007;403:70-9 pubmed..The modular domain structure of RIM-BPs, their expression pattern and the conservative expansion during evolution shown here support their potential role as important molecular adaptors. ..
- Pilhofer M, Rappl K, Eckl C, Bauer A, Ludwig W, Schleifer K, et al. Characterization and evolution of cell division and cell wall synthesis genes in the bacterial phyla Verrucomicrobia, Lentisphaerae, Chlamydiae, and Planctomycetes and phylogenetic comparison with rRNA genes. J Bacteriol. 2008;190:3192-202 pubmed publisher..This implies that Planctomycetes and Chlamydiae may have shifted independently to a non-FtsZ-based cell division mechanism after their separate branchings from their last common ancestor with Verrucomicrobia. ..
- Manvelyan M, Riegel M, Santos M, Fuster C, Pellestor F, Mazaurik M, et al. Thirty-two new cases with small supernumerary marker chromosomes detected in connection with fertility problems: detailed molecular cytogenetic characterization and review of the literature. Int J Mol Med. 2008;21:705-14 pubmed..Nonetheless, further detailed molecular analysis will be necessary in the future to characterize the mechanisms and genetic basis for this phenomenon. ..
- Schilling S, Wasternack C, Demuth H. Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution. Biol Chem. 2008;389:983-91 pubmed publisher..It is possible that the requirement for catalysis of pGlu formation under physiological conditions may have triggered separate evolution of QCs in plants and animals. ..
- Batistic O, Kudla J. Plant calcineurin B-like proteins and their interacting protein kinases. Biochim Biophys Acta. 2009;1793:985-92 pubmed publisher..The occurrence of CBL and CIPK proteins appears not to be restricted to the plant kingdom raising the question about the function of these Ca2+ decoding components in non-plant species. ..
- Sommer R. The future of evo-devo: model systems and evolutionary theory. Nat Rev Genet. 2009;10:416-22 pubmed publisher..Furthermore, a synthesis of evo-devo with population genetics and evolutionary ecology is needed to meet future challenges. ..
- Jordon Thaden I, Hase I, Al Shehbaz I, Koch M. Molecular phylogeny and systematics of the genus Draba (Brassicaceae) and identification of its most closely related genera. Mol Phylogenet Evol. 2010;55:524-40 pubmed publisher..The compilation of these data indicate that true Draba are highly migrating arctic and higher alpine species that are most often perennial with white petals and n=8 as plesiomorphic characters...
- Fischer W, Windhager L, Rohrer S, Zeiller M, Karnholz A, Hoffmann R, et al. Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transfer. Nucleic Acids Res. 2010;38:6089-101 pubmed publisher..Thus, in addition to its natural transformation competence, conjugative transfer of genomic islands has to be considered as an important source of genetic diversity in H. pylori. ..
- Hansen Hagge T, Janssen J, Hameister H, Papa F, Zechner U, Seriu T, et al. An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme. Genomics. 1998;49:411-8 pubmed..This new deubiquitinating enzyme has been named UBH1, for ubiquitin hydrolyzing enzyme 1. ..
- Lang D, Thoma R, Henn Sax M, Sterner R, Wilmanns M. Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion. Science. 2000;289:1546-50 pubmed..The detection of subdomain structures may be useful in efforts to search genome sequences for functionally and structurally related proteins...
- Walter L, Gunther E. Physical mapping and evolution of the centromeric class I gene-containing region of the rat MHC. Immunogenetics. 2000;51:829-37 pubmed..Thus, this insertion is likely to have occurred in a common ancestor of these rodents, although the presence of a site particularly permissive for insertions cannot be excluded. ..
- Oxelmark E, Marchini A, Malanchi I, Magherini F, Jaquet L, Hajibagheri M, et al. Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome. Mol Cell Biol. 2000;20:7784-97 pubmed..5, like Mmf1p, is a soluble protein of the matrix. Our study identifies a biological function for Mmf1p and furthermore indicates that this function is conserved between members of the p14.5 family. ..
- Grabarse W, Mahlert F, Shima S, Thauer R, Ermler U. Comparison of three methyl-coenzyme M reductases from phylogenetically distant organisms: unusual amino acid modification, conservation and adaptation. J Mol Biol. 2000;303:329-44 pubmed publisher..This was reflected in a higher fraction of glutamate residues at the protein surface of the thermophilic enzymes adapted to high intracellular salt concentrations...
- Jenne D, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, et al. Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions. Am J Hum Genet. 2001;69:516-27 pubmed
- Auge H, Neuffer B, Erlinghagen F, Grupe R, Brandl R. Demographic and random amplified polymorphic DNA analyses reveal high levels of genetic diversity in a clonal violet. Mol Ecol. 2001;10:1811-9 pubmed..Although Viola riviniana is a clonal plant, traits associated with sexual reproduction rather than clonality per se are moulding the pattern of genetic variation in this species...
- Traut W, Rahn I, Winking H, Kunze B, Weichehan D. Evolution of a 6-200 Mb long-range repeat cluster in the genus Mus. Chromosoma. 2001;110:247-52 pubmed..Our results suggest a model for the origin and evolution of the long-range repeat cluster by duplication, gene fusion and amplification. ..
- Herrmann R, Maier R, Schmitz Linneweber C. Eukaryotic genome evolution: rearrangement and coevolution of compartmentalized genetic information. Philos Trans R Soc Lond B Biol Sci. 2003;358:87-97; discussion 97 pubmed..Allopolyploidy can influence this phenomenon by providing an increased, cryptic RNA editing potential and the capacity to maintain the integrity of organelles of different taxonomic origins. ..
- Heim M, Jakoby M, Werber M, Martin C, Weisshaar B, Bailey P. The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. Mol Biol Evol. 2003;20:735-47 pubmed..Based on the current characterization of a limited number of plant bHLH proteins, we predict that this family of TFs has a range of different roles in plant cell and tissue development as well as plant metabolism. ..
- Hellmann I, Zollner S, Enard W, Ebersberger I, Nickel B, Paabo S. Selection on human genes as revealed by comparisons to chimpanzee cDNA. Genome Res. 2003;13:831-7 pubmed publisher..This indicates that positive selection may have had a considerable influence on 5'UTRs. The dinucleotide CG (CpG) also exhibits a different substitution pattern within 5'UTRs as compared with other parts of the genome...
- Seltsam A, Hallensleben M, Kollmann A, Blasczyk R. The nature of diversity and diversification at the ABO locus. Blood. 2003;102:3035-42 pubmed..All variant ABO*A/B alleles and one new ABO*O03-like allele were associated with weak ABO phenotypes. These findings are suggestive of the requirement of a comprehensive coding sequence database for sequence-based phenotype prediction. ..
- Delaroque N, Boland W, Müller D, Knippers R. Comparisons of two large phaeoviral genomes and evolutionary implications. J Mol Evol. 2003;57:613-22 pubmed..We speculate that the ancestral genome belonged to a cellular organism that had once invaded a primordial brown algal host...
- Burger J, Rosendahl W, Loreille O, Hemmer H, Eriksson T, Götherström A, et al. Molecular phylogeny of the extinct cave lion Panthera leo spelaea. Mol Phylogenet Evol. 2004;30:841-9 pubmed..The cave lion lineages presented here went extinct without mitochondrial descendants on other continents. The high sequence divergence in the cytochrome b gene between cave and modern lions is notable...
- Meyer A, Kirsch H, Domergue F, Abbadi A, Sperling P, Bauer J, et al. Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis. J Lipid Res. 2004;45:1899-909 pubmed publisher..This may be considered an encouraging first step in future efforts to implement this biosynthetic sequence into transgenic oilseed crops...
- Brandt J, Schrauth S, Veith A, Froschauer A, Haneke T, Schultheis C, et al. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. Gene. 2005;345:101-11 pubmed..Although additional analysis will be required to establish the function of the retrotransposon-derived Mart neogenes, these observations support the evolutionary importance of retrotransposable elements as a source of genetic novelty. ..
- Burmester T, Haberkamp M, Mitz S, Roesner A, Schmidt M, Ebner B, et al. Neuroglobin and cytoglobin: genes, proteins and evolution. IUBMB Life. 2004;56:703-7 pubmed..This result suggests either multiple independent functional changes or a yet undefined respiratory role of tissue globins like Ngb and Cygb. ..
- Krull M, BROSIUS J, Schmitz J. Alu-SINE exonization: en route to protein-coding function. Mol Biol Evol. 2005;22:1702-11 pubmed..The course of these paths can probably be generalized to the exonization of other elements as well. ..
- Haarmann T, Machado C, Lübbe Y, Correia T, Schardl C, Panaccione D, et al. The ergot alkaloid gene cluster in Claviceps purpurea: extension of the cluster sequence and intra species evolution. Phytochemistry. 2005;66:1312-20 pubmed..purpurea is determined by evolution of NRPS module specificity...
- Kemler M, Göker M, Oberwinkler F, Begerow D. Implications of molecular characters for the phylogeny of the Microbotryaceae (Basidiomycota: Urediniomycetes). BMC Evol Biol. 2006;6:35 pubmed..Parasitism on Polygonaceae is likely to be the ancestral state for the Microbotryaceae on Eudicot hosts. ..
- Schluter A, Szczepanowski R, Kurz N, Schneiker S, Krahn I, Puhler A. Erythromycin resistance-conferring plasmid pRSB105, isolated from a sewage treatment plant, harbors a new macrolide resistance determinant, an integron-containing Tn402-like element, and a large region of unknown function. Appl Environ Microbiol. 2007;73:1952-60 pubmed..Comparative genomics of pRSB105 and related plasmids elucidated that pRSB105 evolved by integration of distinct modules from different plasmid sources, including Pseudomonas aeruginosa plasmids, and thus represents a mosaic plasmid...
- Suchanek M, Hynynen R, Wohlfahrt G, Lehto M, Johansson M, Saarinen H, et al. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Biochem J. 2007;405:473-80 pubmed..In addition, the ORP1L variant and ORP3, ORP5, and ORP8 were cross-linked with photoCH. The present study identifies ORP1 and ORP2 as OSBPs and suggests that most of the mammalian ORPs are able to bind sterols. ..
- Korb J, Weil T, Hoffmann K, Foster K, Rehli M. A gene necessary for reproductive suppression in termites. Science. 2009;324:758 pubmed publisher..We used a combination of behavioral assays and RNA interference (RNAi) to identify a gene required for the reproductive division of labor between the queen and the workers. ..
- Schirawski J, Mannhaupt G, Münch K, Brefort T, Schipper K, Doehlemann G, et al. Pathogenicity determinants in smut fungi revealed by genome comparison. Science. 2010;330:1546-8 pubmed publisher..maydis, we demonstrate a role in virulence for four previously unknown diversity regions. This highlights the power of comparative genomics of closely related species for identification of virulence determinants...
- Lücke C, Huang S, Rademacher M, Rüterjans H. New insights into intracellular lipid binding proteins: The role of buried water. Protein Sci. 2002;11:2382-92 pubmed
- Fiebig A, Stegemann S, Bock R. Rapid evolution of RNA editing sites in a small non-essential plastid gene. Nucleic Acids Res. 2004;32:3615-22 pubmed..Accumulated evidence for this 'relative neutrality hypothesis for the evolution of plastid editing sites' is discussed. ..
- Groeneveld L, Clausnitzer V, Hadrys H. Convergent evolution of gigantism in damselflies of Africa and South America? Evidence from nuclear and mitochondrial sequence data. Mol Phylogenet Evol. 2007;42:339-46 pubmed..Because modern odonates evolved before the split of Africa from Gondwanaland, the proposed phylogeny suggests that C. grandis represents a Gondwana relict. ..
- Jakob S, Blattner F. Two extinct diploid progenitors were involved in allopolyploid formation in the Hordeum murinum (Poaceae: Triticeae) taxon complex. Mol Phylogenet Evol. 2010;55:650-9 pubmed publisher..murinum. None of the used molecular markers revealed a strong geographic pattern of genetic variation that would allow comprehensive phylogeographic analysis, most probably due to the very effective seed dispersal of the taxa. ..
- Alsheimer M, Baier A, Schramm S, Schutz W, Benavente R. Synaptonemal complex protein SYCP3 exists in two isoforms showing different conservation in mammalian evolution. Cytogenet Genome Res. 2010;128:162-8 pubmed publisher..However, the longer isoform, which represents an N-terminal extension of the shorter one, most likely appeared about 15 million years ago in a common ancestor of rat and mouse and after separation from the hamster branch. ..
- Zeller R, Haramis A, Zuniga A, McGuigan C, Dono R, Davidson G, et al. Formin defines a large family of morphoregulatory genes and functions in establishment of the polarising region. Cell Tissue Res. 1999;296:85-93 pubmed
- Kammerer R, Popp T, Singer B, Schlender J, Zimmermann W. Identification of allelic variants of the bovine immune regulatory molecule CEACAM1 implies a pathogen-driven evolution. Gene. 2004;339:99-109 pubmed..This is consistent with the notion that CEACAM1 serves or has served as a pathogen receptor in cattle. ..
- Prohaska S, Stadler P. Evolution of the vertebrate ParaHox clusters. J Exp Zool B Mol Dev Evol. 2006;306:481-7 pubmed
- Shintani S, O hUigin C, Toyosawa S, Michalov V, Klein J. Origin of gene overlap: the case of TCP1 and ACAT2. Genetics. 1999;152:743-54 pubmed..One or both of the transposed genes found by chance signals that are necessary for the processing of their transcripts to be present on the noncoding strand of the partner gene...
- Perseke M, Fritzsch G, Ramsch K, Bernt M, Merkle D, Middendorf M, et al. Evolution of mitochondrial gene orders in echinoderms. Mol Phylogenet Evol. 2008;47:855-64 pubmed publisher..Only two of these rearrangements are inversions, while we identify three tandem-duplication-random-loss events and three transpositions. ..
- Ueffing N, Singh K, Christians A, Thorns C, Feller A, Nagl F, et al. A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein. Blood. 2009;114:572-9 pubmed publisher..A comparison of 183 patients with follicular lymphoma and 233 population controls revealed an increased lymphoma risk associated with the rs10190751 A genotype causing c-FLIP(R) expression. ..
- Say R, Fuchs G. Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral gluconeogenic enzyme. Nature. 2010;464:1077-81 pubmed publisher..We propose that this highly conserved, heat-stabile and bifunctional FBP aldolase/phosphatase represents the pace-making ancestral gluconeogenic enzyme, and that in evolution gluconeogenesis preceded glycolysis...
- Bozek K, Lengauer T. Positive selection of HIV host factors and the evolution of lentivirus genes. BMC Evol Biol. 2010;10:186 pubmed publisher..Individual host factors pointed to by our analysis might merit further study as potential targets of antiretroviral therapies. ..
- Sudhop S, Coulier F, Bieller A, Vogt A, Hotz T, Hassel M. Signalling by the FGFR-like tyrosine kinase, Kringelchen, is essential for bud detachment in Hydra vulgaris. Development. 2004;131:4001-11 pubmed publisher..Although Kringelchen groups with the FGFR family, it is not known whether this protein is able to bind FGFs, which have not been isolated from Hydra so far...
- Muller V, Lingl A, Lewalter K, Fritz M. ATP synthases with novel rotor subunits: new insights into structure, function and evolution of ATPases. J Bioenerg Biomembr. 2005;37:455-60 pubmed
- Pogoda H, Hammerschmidt M. Molecular genetics of pituitary development in zebrafish. Semin Cell Dev Biol. 2007;18:543-58 pubmed..Finally, we discuss future directions, with particular focus on evolutionary aspects, and some novel functional aspects with growing medical and social relevance. ..
- Lott P, Mundry M, Sassenberg C, Lorkowski S, Fuellen G. Simplifying gene trees for easier comprehension. BMC Bioinformatics. 2006;7:231 pubmed..It yields results of similar quality as manual simplification. It should be valuable in phylogenetic studies of large protein families. The software is available at http://www.uni-muenster.de/Bioinformatics/services/treesim/. ..
- Huber K. The sympathoadrenal cell lineage: specification, diversification, and new perspectives. Dev Biol. 2006;298:335-43 pubmed
- Heinen T, Staubach F, Häming D, Tautz D. Emergence of a new gene from an intergenic region. Curr Biol. 2009;19:1527-31 pubmed publisher..Our results show that cryptic signals for transcript regulation and processing exist in intergenic regions and can become the basis for the evolution of a new functional gene. ..
- Bock R. The give-and-take of DNA: horizontal gene transfer in plants. Trends Plant Sci. 2010;15:11-22 pubmed publisher..Here, I summarize current knowledge about HGT in plants, discuss possible molecular mechanisms and adaptive values of HGT events and highlight recent progress made in reconstructing HGT processes in laboratory experiments. ..
- Hollemann T, Bellefroid E, Pieler T. The Xenopus homologue of the Drosophila gene tailless has a function in early eye development. Development. 1998;125:2425-32 pubmed..These findings suggest that Xtll serves an important regulatory function in the earliest phases of vertebrate eye development. ..
- Herlyn H, Zischler H. Sequence evolution, processing, and posttranslational modification of zonadhesin D domains in primates, as inferred from cDNA data. Gene. 2005;362:85-97 pubmed..A high conservation of processing and dimerization motifs of primate zonadhesin in analogy to pig, on the other hand, illustrates that zonadhesin's backbone needs to meet basic requirements in order to retain function. ..
- Meyer B, Kuever J. Molecular analysis of the distribution and phylogeny of dissimilatory adenosine-5'-phosphosulfate reductase-encoding genes (aprBA) among sulfur-oxidizing prokaryotes. Microbiology. 2007;153:3478-98 pubmed..The putative functional role of the SRP-related APS reductases in photo- and chemotrophic SOP is discussed...
- Shavit Grievink L, Penny D, Hendy M, Holland B. Phylogenetic tree reconstruction accuracy and model fit when proportions of variable sites change across the tree. Syst Biol. 2010;59:288-97 pubmed publisher..In addition, we show that increased sampling of taxa that have undergone a change in proportion and positions of variable sites is critical for accurate tree reconstruction. ..
- Potrawfke T, Armengaud J, Wittich R. Chlorocatechols substituted at positions 4 and 5 are substrates of the broad-spectrum chlorocatechol 1,2-dioxygenase of Pseudomonas chlororaphis RW71. J Bacteriol. 2001;183:997-1011 pubmed..These novel characteristics of TetC thus differ significantly from results obtained from hitherto analyzed catechol 1,2-dioxygenases and chlorocatechol 1,2-dioxygenases. ..
- Iozef R, Rahlfs S, Chang T, Schirmer H, Becker K. Glyoxalase I of the malarial parasite Plasmodium falciparum: evidence for subunit fusion. FEBS Lett. 2003;554:284-8 pubmed..These results support the hypothesis of domain-swapping and subunit fusion as mechanisms in glyoxalase I evolution. ..
- Kraemer A, Saraiva L, Korsching S. Structural and functional diversification in the teleost S100 family of calcium-binding proteins. BMC Evol Biol. 2008;8:48 pubmed publisher..Accordingly, our findings provide an excellent basis for future studies of the functions and interaction partners of s100 genes and finally their role in diseases, using the zebrafish as a model organism. ..
- Kammerer S, Arnold N, Gutensohn W, Mewes H, Kunau W, Höfler G, et al. Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein. Genomics. 1997;45:200-10 pubmed..This localization together with the similarity to a peroxisomal assembly protein from Saccharomyces cerevisiae suggests HsPXF is involved in the process of peroxisomal biogenesis or assembly. ..
- Meyer B, Imhoff J, Kuever J. Molecular analysis of the distribution and phylogeny of the soxB gene among sulfur-oxidizing bacteria - evolution of the Sox sulfur oxidation enzyme system. Environ Microbiol. 2007;9:2957-77 pubmed..A putative scenario for the proteobacterial origin and evolution of the Sox enzyme system in SOB is presented considering the phylogenetic, genomic (sox gene cluster composition) and geochemical data...
- Munsterkotter M, Steinberg G. The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae. BMC Genomics. 2007;8:473 pubmed..The identification of functionally un-characterized genes that are conserved in humans and U. maydis opens the door for experimental work, which promises new insight in the cell biology of the mammalian cell. ..
- Rozhdestvensky T, Kopylov A, Brosius J, Huttenhofer A. Neuronal BC1 RNA structure: evolutionary conversion of a tRNA(Ala) domain into an extended stem-loop structure. RNA. 2001;7:722-30 pubmed..The three distinct structural domains reflect evolutionary legacies of BC1 RNA. ..
- Fondufe Mittendorf Y, Härer C, Kramer W, Fritz H. Two amino acid replacements change the substrate preference of DNA mismatch glycosylase Mig.MthI from T/G to A/G. Nucleic Acids Res. 2002;30:614-21 pubmed..The results also offer an explanation for why so many different substrate specificities are realized within the HhH superfamily of DNA repair glycosylases, and they widen the scope of these enzymes as practical tools. ..
- Ober D, Harms R, Witte L, Hartmann T. Molecular evolution by change of function. Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein. J Biol Chem. 2003;278:12805-12 pubmed..It is suggested as having evolved from deoxyhypusine synthase by gene duplication and being recruited for a new function. ..
- Paschen S, Waizenegger T, Stan T, Preuss M, Cyrklaff M, Hell K, et al. Evolutionary conservation of biogenesis of beta-barrel membrane proteins. Nature. 2003;426:862-6 pubmed..We present evidence that important elements of the topogenesis of beta-barrel membrane proteins have been conserved during the evolution of mitochondria from endosymbiotic bacterial ancestors. ..