Genomes and Genes
Experts and Doctors on mitosis in United States
Locale: United States
Publications343 found, 100 shown here
- Akiyoshi B, Nelson C, Biggins S. The aurora B kinase promotes inner and outer kinetochore interactions in budding yeast. Genetics. 2013;194:785-9 pubmed publisher..The Dsn1 component is crucial for kinetochore assembly and is phosphorylated by the Aurora B kinase. We found that Aurora B phosphorylation of Dsn1 promotes the interaction between outer and inner kinetochore proteins in budding yeast. ..
- Qiao D, Yang X, Meyer K, Friedl A. Glypican-1 regulates anaphase promoting complex/cyclosome substrates and cell cycle progression in endothelial cells. Mol Biol Cell. 2008;19:2789-801 pubmed publisher..These observations suggest that GPC1 regulates EC cell cycle progression at least partially by modulating APC/C-mediated degradation of mitotic cyclins and securin. ..
- Compton D, Luo C. Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis. J Cell Sci. 1995;108 ( Pt 2):621-33 pubmed
- Richman T, Sawyer M, Johnson D. The Cdc42p GTPase is involved in a G2/M morphogenetic checkpoint regulating the apical-isotropic switch and nuclear division in yeast. J Biol Chem. 1999;274:16861-70 pubmed
- Verbrugghe K, White J. Cortical centralspindlin and G alpha have parallel roles in furrow initiation in early C. elegans embryos. J Cell Sci. 2007;120:1772-8 pubmed..We also found spindle length or microtubule distribution did not correlate with furrow initiation. We propose that centralspindlin acts redundantly with G alpha to regulate furrow initiation. ..
- Uppal S, Li Y, Wendt E, Cayer M, Barnes J, Conway D, et al. Pattern analysis of microtubule-polymerizing and -depolymerizing agent combinations as cancer chemotherapies. Int J Oncol. 2007;31:1281-91 pubmed..These therapies appear to restore in transformed cells some of the features of a contact-inhibited cell, and to impede progress through the cell cycle even when provided at nanomolar concentrations. ..
- Starnes J, Thornbury D, Novikova O, Rehmeyer C, Farman M. Telomere-targeted retrotransposons in the rice blast fungus Magnaporthe oryzae: agents of telomere instability. Genetics. 2012;191:389-406 pubmed publisher..Genetic evidence indicates that the MoTeR elements are responsible for the observed instability. MoTeRs represent a new family of telomere-targeted transposons whose members are found exclusively in fungi. ..
- Cai Z, Mehendale H. Resiliency to amplification of carbon tetrachloride hepatotoxicity by chlordecone during postnatal development in rats. Pediatr Res. 1993;33:225-32 pubmed..These data suggest that the absence of potentiation of CCl4 toxicity by chlordecone in postnatally developing rats is well correlated with the presence of ongoing and stimulatable hepatocellular regenerative activity. ..
- Huang Y, Fang Y, Wu J, Dziadyk J, Zhu X, Sui M, et al. Regulation of Vinca alkaloid-induced apoptosis by NF-kappaB/IkappaB pathway in human tumor cells. Mol Cancer Ther. 2004;3:271-7 pubmed..These findings suggest that the NF-kappaB/IkappaB signaling pathway may contribute to the mediation of Vinca alkaloid-induced apoptosis in human tumor cells. ..
- Roh M, Song C, Kim J, Abdulkadir S. Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1. J Biol Chem. 2005;280:40568-77 pubmed..These results indicated that chronic Pim-1 overexpression dysregulates cyclin B1 protein expression, which contributes to the development of polyploidy by delaying cytokinesis. ..
- Marchetti M, Weinberger M, Murakami Y, Burhans W, Huberman J. Production of reactive oxygen species in response to replication stress and inappropriate mitosis in fission yeast. J Cell Sci. 2006;119:124-31 pubmed..Thus, studies in fission yeast are likely to prove helpful in understanding the pathways that lead from replication stress and inappropriate mitosis to cell death in mammalian cells. ..
- Sitko J, Yeh B, Kim M, Zhou H, Takaesu G, Yoshimura A, et al. SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage. Cell Signal. 2008;20:2221-30 pubmed publisher..Our results suggest a novel function for SOCS3 in the control of genome stability by negatively regulating STAT3-dependent radioresistant DNA synthesis, and promoting p53-dependent p21 expression. ..
- Brinkkoetter P, Olivier P, Wu J, Henderson S, Krofft R, Pippin J, et al. Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells. J Clin Invest. 2009;119:3089-101 pubmed publisher..Taken together, these data suggest that a cyclin I-Cdk5 complex forms a critical antiapoptotic factor in terminally differentiated cells that functions via MAPK signaling to modulate levels of the prosurvival proteins Bcl-2 and Bcl-XL. ..
- Stevens K, Kelemen L, Wang X, Fridley B, Vierkant R, Fredericksen Z, et al. Common variation in Nemo-like kinase is associated with risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2012;21:523-8 pubmed publisher..An association between SNPs in NLK and ovarian cancer may provide biologic insight into the development of this disease. ..
- Francia M, Jordan C, Patel J, Sheiner L, Demerly J, Fellows J, et al. Cell division in Apicomplexan parasites is organized by a homolog of the striated rootlet fiber of algal flagella. PLoS Biol. 2012;10:e1001444 pubmed publisher..Instead of ensuring appropriate numbers of flagella, the system now positions the apical invasion complexes. This suggests that elements of the invasion apparatus may be derived from flagella or flagellum associated structures...
- Spicer L, Aad P. Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor. Biol Reprod. 2007;77:18-27 pubmed..In particular, increased free IGF1 in developing follicles may decrease synthesis of IGF2R, thereby allowing for more IGF2 to be bioavailable (free) for induction of steroidogenesis and mitogenesis via the IGF1R. ..
- Toczyski D, Galgoczy D, Hartwell L. CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Cell. 1997;90:1097-106 pubmed
- Schmidt D, Rose D, Saxton W, Strome S. Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Mol Biol Cell. 2005;16:1200-12 pubmed..This suggests that temperature-sensitive mutations can be created for time-resolved function analyses of dyneins and perhaps other P-loop proteins in a variety of model systems. ..
- Yu X, Minter Dykhouse K, Malureanu L, Zhao W, Zhang D, Merkle C, et al. Chfr is required for tumor suppression and Aurora A regulation. Nat Genet. 2005;37:401-6 pubmed..Collectively, our data suggest that Chfr is a tumor suppressor and ensures chromosomal stability by controlling the expression levels of key mitotic proteins such as Aurora A. ..
- Yuan L, Yu W, Xu M, Qu C. SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively. J Biol Chem. 2005;280:42701-6 pubmed..Collectively, these studies have further defined the mechanisms by which SHP-2 phosphatase regulates DNA damage responses. ..
- Gilliland W, Hughes S, Cotitta J, Takeo S, Xiang Y, Hawley R. The multiple roles of mps1 in Drosophila female meiosis. PLoS Genet. 2007;3:e113 pubmed..These filaments polymerize during early germinal vesicle breakdown, perhaps as a means of storing excess outer kinetochore kinases during early embryonic development. ..
- Lingle W, Lukasiewicz K, Salisbury J. Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer. Adv Exp Med Biol. 2005;570:393-421 pubmed publisher..Centrosome amplification, therefore, can serve to exacerbate and/or generate genetic instabilities associated with cancers. ..
- Compton D. Chromosome segregation: pulling from the poles. Curr Biol. 2002;12:R651-3 pubmed..The data reveal that poleward microtubule flux provides the dominant force for separating chromatids in Drosophila embryos during anaphase A. ..
- Englund C, Fink A, Lau C, Pham D, Daza R, Bulfone A, et al. Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex. J Neurosci. 2005;25:247-51 pubmed
- Brito D, Rieder C. Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr Biol. 2006;16:1194-200 pubmed..Thus, vertebrate cells do not adapt to the SAC. Rather, our data suggest that in normal cells, the SAC cannot prevent a slow but continuous degradation of cyclin B that ultimately drives the cell out of mitosis. ..
- Cafaro J, Lee G, Stone J. Atoh1 expression defines activated progenitors and differentiating hair cells during avian hair cell regeneration. Dev Dyn. 2007;236:156-70 pubmed..These observations suggest a role for Atoh1 in re-specifying supporting cells and in biasing postmitotic cells toward the hair cell fate during hair cell regeneration in the mature chicken ear. ..
- McNeely S, Belshoff A, Taylor B, Fan T, McCabe M, Pinhas A, et al. Sensitivity to sodium arsenite in human melanoma cells depends upon susceptibility to arsenite-induced mitotic arrest. Toxicol Appl Pharmacol. 2008;229:252-61 pubmed publisher..These data suggest that arsenite has potential for treatment of solid tumors but a functional spindle checkpoint is a prerequisite for a positive response to its clinical application. ..
- Kieserman E, Wallingford J. In vivo imaging reveals a role for Cdc42 in spindle positioning and planar orientation of cell divisions during vertebrate neural tube closure. J Cell Sci. 2009;122:2481-90 pubmed publisher..Our data provide new insights into the coordination of cell division and morphogenesis in epithelial cell sheets and reveal novel, cell-type-specific roles for Cdc42 in spindle positioning and spindle orientation. ..
- Duncan A, Taylor M, Hickey R, Hanlon Newell A, Lenzi M, Olson S, et al. The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature. 2010;467:707-10 pubmed publisher..We propose that this mechanism evolved to generate genetic diversity and permits adaptation of hepatocytes to xenobiotic or nutritional injury. ..
- Martin C, Ahmad I, Klingseisen A, Hussain M, Bicknell L, Leitch A, et al. Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat Genet. 2014;46:1283-1292 pubmed publisher..Furthermore, we establish that different levels of impaired PLK4 activity result in growth and cilia phenotypes, providing a mechanism by which microcephaly disorders can occur with or without ciliopathic features. ..
- Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science. 1999;283:1321-5 pubmed..Thus, in some cells, telomere shortening may signal cell death rather than senescence. ..
- Taylor B, McNeely S, Miller H, Lehmann G, McCabe M, States J. p53 suppression of arsenite-induced mitotic catastrophe is mediated by p21CIP1/WAF1. J Pharmacol Exp Ther. 2006;318:142-51 pubmed..The data indicate that p53 mediates cyclin B/CDC2 inactivation and mitotic release directly via p21CIP1/WAF1 induction. ..
- Place S, Smith B. Effects of seawater acidification on cell cycle control mechanisms in Strongylocentrotus purpuratus embryos. PLoS ONE. 2012;7:e34068 pubmed publisher..These data suggest low pH environments may not impact developmental programs directly, but may act through secondary mechanisms such as cellular energetics...
- Jiang L, Rong R, Sheikh M, Huang Y. Cullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis. J Biol Chem. 2011;286:6971-8 pubmed publisher..Thus, our present study demonstrates that the CUL4A·DDB1 E3 complex is important for regulation of RASSF1A during mitosis, and it may contribute to inactivation of RASSF1A and promoting cell cycle progression. ..
- Ye X, Fincher R, Tang A, McNeal K, Gygax S, Wexler A, et al. Proteolysis and tyrosine phosphorylation of p34cdc2/cyclin B. The role of MCM2 and initiation of DNA replication to allow tyrosine phosphorylation of p34cdc2. J Biol Chem. 1997;272:33384-93 pubmed..We also show that cells arrested at G1/S due to lack of nimQMCM2 continue to replicate spindle pole bodies in the absence of DNA replication and can undergo anaphase in the absence of APC function. ..
- Mitchell D, Sprague G. The phosphotyrosyl phosphatase activator, Ncs1p (Rrd1p), functions with Cla4p to regulate the G(2)/M transition in Saccharomyces cerevisiae. Mol Cell Biol. 2001;21:488-500 pubmed..Strains lacking both NCS1 and NOH1 were inviable and arrested as unbudded cells, implying that PTPA function is required for proper G(1) progression. ..
- Biggins S, Murray A. The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes Dev. 2001;15:3118-29 pubmed..Ipl1p localizes at or near kinetochores during mitosis, and we propose that Ipl1p is required to monitor tension at the kinetochore. ..
- Carter R, Giudice C, Dubielzig R, Colitz C. Telomerase activity with concurrent loss of cell cycle regulation in feline post-traumatic ocular sarcomas. J Comp Pathol. 2005;133:235-45 pubmed publisher..These findings suggest that p16, and not p53, represents the primary mechanism by which post-traumatic ocular sarcomas that express telomerase activity escape cell cycle control...
- Klovstad M, Abdu U, Schupbach T. Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint. PLoS Genet. 2008;4:e31 pubmed publisher..In addition, Brca2 co-immunoprecipitates with the checkpoint protein Rad9, suggesting a direct role for Brca2 in the transduction of the meiotic recombination checkpoint signal. ..
- Jeong J, Verheyden J, Kimble J. Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans. PLoS Genet. 2011;7:e1001348 pubmed publisher..Therefore, CYE-1/CDK-2 emerges as a critical regulator of stem cell maintenance. We suggest that cyclin E and Cdk-2 may be used broadly to control developmental regulators. ..
- Rieder C, Cole R. Entry into mitosis in vertebrate somatic cells is guarded by a chromosome damage checkpoint that reverses the cell cycle when triggered during early but not late prophase. J Cell Biol. 1998;142:1013-22 pubmed..Together, these data reveal that a checkpoint control exists in early but not late prophase in vertebrate cells that, when triggered, reverses the cell cycle by apparently downregulating existing cyclin-dependent kinase (CDK1) activity. ..
- Dawe R, Reed L, Yu H, Muszynski M, Hiatt E. A maize homolog of mammalian CENPC is a constitutive component of the inner kinetochore. Plant Cell. 1999;11:1227-38 pubmed..CENPC and a previously identified centromeric DNA sequence interact closely but do not strictly colocalize on meiotic chromosomes. These and other data indicate that CENPC occupies an inner domain of the maize kinetochore. ..
- Mack G, Compton D. Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein. Proc Natl Acad Sci U S A. 2001;98:14434-9 pubmed..Thus, we have generated a comprehensive list of major mitotic microtubule-associated proteins, among which is astrin, a nonmotor spindle protein. ..
- Evans J, Sumners C, Moore J, Huentelman M, Deng J, Gelband C, et al. Characterization of mitotic neurons derived from adult rat hypothalamus and brain stem. J Neurophysiol. 2002;87:1076-85 pubmed..These cells therefore have the immunological and electrophysiological properties of immature mitotic neurons and should be useful in a variety of future studies of neuronal differentiation and function. ..
- Liu Cm C, McElver J, Tzafrir I, Joosen R, Wittich P, Patton D, et al. Condensin and cohesin knockouts in Arabidopsis exhibit a titan seed phenotype. Plant J. 2002;29:405-15 pubmed..Further analysis of titan mutants and the SMC gene family in Arabidopsis should provide clues to chromosome mechanics in plants and insights into the regulation of nuclear activity during endosperm development. ..
- Fong Y, Bender L, Wang W, Strome S. Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans. Science. 2002;296:2235-8 pubmed..We propose that all four MES proteins participate in X-chromosome silencing, and that the role of MES-4 is to exclude repressors from the autosomes, thus enabling efficient repression of the Xs. ..
- Suh N, Jedamzik B, Eckmann C, Wickens M, Kimble J. The GLD-2 poly(A) polymerase activates gld-1 mRNA in the Caenorhabditis elegans germ line. Proc Natl Acad Sci U S A. 2006;103:15108-12 pubmed..Therefore, a molecular switch regulates gld-1 mRNA activity to accomplish the transition from mitosis to meiosis. ..
- Drakakaki G, Zabotina O, Delgado I, Robert S, Keegstra K, Raikhel N. Arabidopsis reversibly glycosylated polypeptides 1 and 2 are essential for pollen development. Plant Physiol. 2006;142:1480-92 pubmed..Taken together, our results indicate that RGP1 and RGP2 are required during microspore development and pollen mitosis, either affecting cell division and/or vacuolar integrity. ..
- Wood M, Sanchez Y. Deregulated Ras signaling compromises DNA damage checkpoint recovery in S. cerevisiae. Cell Cycle. 2010;9:3353-63 pubmed publisher..This work identifies a new signaling pathway that can regulate DNA damage checkpoint recovery and implicates the Ras signaling pathway as an important regulator of mitotic events. ..
- Bitel C, Perrone Bizzozero N, Frederikse P. HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens. Mol Vis. 2010;16:2301-16 pubmed
- Smith S, Kiss D, Turk E, Tartakoff A, Andrulis E. Pronounced and extensive microtubule defects in a Saccharomyces cerevisiae DIS3 mutant. Yeast. 2011;28:755-69 pubmed publisher..Collectively, the data presented in this study suggest an evolutionarily conserved role for Dis3 in linking RNA metabolism, MTs and cell cycle progression. ..
- Cholewa B, Liu X, Ahmad N. The role of polo-like kinase 1 in carcinogenesis: cause or consequence?. Cancer Res. 2013;73:6848-55 pubmed publisher..However, evidence supports the notion that oncogene dependence on Plk1 is not a late occurrence in carcinogenesis and it is likely that Plk1 plays an active role in carcinogenic transformation. ..
- Diehl N, Enslen H, Fortner K, Merritt C, Stetson N, Charland C, et al. Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo. J Exp Med. 2000;191:321-34 pubmed..Therefore, the p38 MAP kinase pathway is a critical regulatory element of differentiation and proliferation during the early stages of in vivo thymocyte development. ..
- Kline Smith S, Walczak C. Microtubules in orbit. J Cell Biol. 2000;149:5-6 pubmed
- Standley P, Stanley M, Senechal P. Activation of mitogenic and antimitogenic pathways in cyclically stretched arterial smooth muscle. Am J Physiol Endocrinol Metab. 2001;281:E1165-71 pubmed..These two molecules regulate each other's secretory rates, providing tight regulation of VSMC proliferation. These data may have profound implications in understanding vascular growth alterations in vascular injury and hypertension...
- Savoian M, Rieder C. Mitosis in primary cultures of Drosophila melanogaster larval neuroblasts. J Cell Sci. 2002;115:3061-72 pubmed
- Lee M, Hook B, Lamont L, Wickens M, Kimble J. LIP-1 phosphatase controls the extent of germline proliferation in Caenorhabditis elegans. EMBO J. 2006;25:88-96 pubmed..The control of germline proliferation by LIP-1 has intriguing parallels with the control of stem cells and progenitor cells in vertebrates. ..
- Hogarth C, Mitchell D, Evanoff R, Small C, Griswold M. Identification and expression of potential regulators of the mammalian mitotic-to-meiotic transition. Biol Reprod. 2011;84:34-42 pubmed publisher..Future research will be directed at determining a specific role for these three proteins in germ cell differentiation. ..
- Chattergoon N, Louey S, STORK P, Giraud G, Thornburg K. Mid-gestation ovine cardiomyocytes are vulnerable to mitotic suppression by thyroid hormone. Reprod Sci. 2012;19:642-9 pubmed publisher..Contrary to our hypothesis, elevated levels of T(3) powerfully inhibit proliferation of midgestation fetal cardiomyocytes. Thus, midgestation maternal hyperthyroidism might lead to an underendowed fetal myocardium. ..
- Schmit T, Nihal M, Ndiaye M, Setaluri V, Spiegelman V, Ahmad N. Numb regulates stability and localization of the mitotic kinase PLK1 and is required for transit through mitosis. Cancer Res. 2012;72:3864-72 pubmed publisher..We suggest that dysregulation of Numb expression results in mislocalized Plk1 and poor centrosomal ?-tubulin recruitment, potentially contributing to mitotic errors, aneuploidy, and cancer development. ..
- Denu R, Zasadil L, Kanugh C, Laffin J, Weaver B, Burkard M. Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer. BMC Cancer. 2016;16:47 pubmed publisher..CA promotes high-risk breast cancer in part by inducing high-grade features. These findings highlight the importance of centrosome aberrations in the biology of human breast cancer. ..
- Decarreau J, Wagenbach M, Lynch E, Halpern A, Vaughan J, KOLLMAN J, et al. The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindleÂ orientation. Nat Cell Biol. 2017;19:384-390 pubmed publisher..The activity of Kif25 during interphase is required to maintain a centred nucleus to ensure the spindle is stably oriented at the onset ofÂ mitosis. ..
- Voura E, Montalvo M, Dela Roca K, Fisher J, Defamie V, Narala S, et al. Planarians as models of cadmium-induced neoplasia provide measurable benchmarks for mechanistic studies. Ecotoxicol Environ Saf. 2017;142:544-554 pubmed publisher..From these results, we infer that neoblast activity does respond to cadmium-induced tumor growth, and that metalloproteinases are required for the progression of cancer in the planarian. ..
- Wahls W, Smith G. A heteromeric protein that binds to a meiotic homologous recombination hot spot: correlation of binding and hot spot activity. Genes Dev. 1994;8:1693-702 pubmed..These and other data suggest that homologous recombination may be regulated primarily by discrete DNA sites and proteins that interact with those sites. ..
- Wang X, Yew N, Peloquin J, Vande Woude G, Borisy G. Mos oncogene product associates with kinetochores in mammalian somatic cells and disrupts mitotic progression. Proc Natl Acad Sci U S A. 1994;91:8329-33 pubmed..Our results suggest that mitotic blockage by Mos may result from an action of the Mos kinase on the kinetochores, thus increasing chromosome instability and preventing normal congression. ..
- Maricich S, Herrup K. Pax-2 expression defines a subset of GABAergic interneurons and their precursors in the developing murine cerebellum. J Neurobiol. 1999;41:281-94 pubmed..Finally, our data support the hypothesis that the basket and stellate cells arise from neuronally restricted, migratory precursors located in the early postnatal cerebellar white matter. ..
- Cormier R, Dove W. Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. Cancer Res. 2000;60:3965-70 pubmed..This finding may provide an insight into potential combinatorial therapeutic approaches for treating human colon cancer. ..
- Levesque A, Compton D. The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. J Cell Biol. 2001;154:1135-46 pubmed..This force increases the efficiency with which chromosomes make bipolar spindle attachments and regulates kinetochore activities necessary for chromosome oscillation, but is not essential for chromosome congression. ..
- Deng X, Mercer S, Shah S, Ewton D, Friedman E. The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase. J Biol Chem. 2004;279:22498-504 pubmed..In addition, depletion of Mirk by RNA(i) in postmitotic C2C12 myoblasts decreased protein but not mRNA levels of p27, suggesting that stabilization of p27 by Mirk also occurs during differentiation. ..
- Othman M, Lu C, Klueber K, Winstead W, Roisen F. Clonal analysis of adult human olfactory neurosphere forming cells. Biotech Histochem. 2005;80:189-200 pubmed..Therefore, they are a unique source of progenitors for future cell replacement strategies in the treatment of neurotrauma and neurodegenerative diseases. ..
- Law L, Gardner R, Allen T, Lee D. Species-specific injury-induced cell proliferation in the hippocampus and subventricular zone of food-storing and nonstoring wild birds. Dev Neurobiol. 2010;70:16-27 pubmed publisher..These species differences may provide a useful model for isolating factors involved in cellular responses following injury. ..
- Hizli A, Chi Y, Swanger J, Carter J, Liao Y, Welcker M, et al. Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase. Mol Cell Biol. 2013;33:596-604 pubmed publisher..Because all known eEF2 regulation is exerted via eEF2K, S595 phosphorylation may globally couple the cell cycle machinery to regulatory pathways that impact eEF2K activity. ..
- Melloy P, Rose M. Influence of the bud neck on nuclear envelope fission in Saccharomyces cerevisiae. Exp Cell Res. 2017;358:390-396 pubmed publisher..In addition, 27% of myo1? mutant nuclei completed karyokinesis. These data suggested that fission is not dependent on mechanical contraction at the bud neck, but was instead controlled by regulatory proteins there. ..
- Austin J, Kimble J. glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans. Cell. 1987;51:589-99 pubmed..Mosaic analyses suggest that glp-1 is produced in the germ line. We propose that glp-1 acts as part of the receiving mechanism in the interaction between the distal tip cell and germ line. ..
- Wetzler M, Talpaz M, Yee G, Stass S, Van Etten R, Andreeff M, et al. Cell cycle-related shifts in subcellular localization of BCR: association with mitotic chromosomes and with heterochromatin. Proc Natl Acad Sci U S A. 1995;92:3488-92 pubmed..Results were similar in cell lines of lymphoid or myeloid origin. These observations suggest a role for BCR in the phosphokinase interactions linked to condensed chromatin, a network previously implicated in cell cycle regulation. ..
- Kumagai A, Yakowec P, Dunphy W. 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts. Mol Biol Cell. 1998;9:345-54 pubmed..These findings indicate that 14-3-3 proteins act as negative regulators of Cdc25 in controlling the G2-M transition. ..
- Platero J, Csink A, Quintanilla A, Henikoff S. Changes in chromosomal localization of heterochromatin-binding proteins during the cell cycle in Drosophila. J Cell Biol. 1998;140:1297-306 pubmed..Upon decondensation, GAGA factor and Prod shift from low affinity sites within satellite DNA back to euchromatic sites as a self-assembly process. ..
- Dua R, Levy D, Campbell J. Role of the putative zinc finger domain of Saccharomyces cerevisiae DNA polymerase epsilon in DNA replication and the S/M checkpoint pathway. J Biol Chem. 1998;273:30046-55 pubmed..The POL2 C terminus is sufficient for interaction with DPB2, the essential and phylogenetically conserved subunit of pol epsilon, but not for interaction with DPB3. Neither Dpb3p nor Dpb2p homodimerizes in the two-hybrid assay. ..
- Shou W, Seol J, Baskerville C, Moazed D, Chen Z, Jang J, et al. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell. 1999;97:233-44 pubmed..Nucleolar sequestration may be a general mechanism for the regulation of diverse biological processes. ..
- Feng H, Zhong W, Punkosdy G, Gu S, Zhou L, Seabolt E, et al. CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nat Cell Biol. 1999;1:486-92 pubmed..In cul-2 mutant embryos, mitotic chromosomes are unable to condense, leading to unequal DNA segregation, chromosome bridging and the formation of multiple nuclei. ..
- Polinko E, Strome S. Depletion of a Cks homolog in C. elegans embryos uncovers a post-metaphase role in both meiosis and mitosis. Curr Biol. 2000;10:1471-4 pubmed..Specifically, cks-1(RNAi) embryos fail to exit M phase properly. We propose that CKS-1 has an essential role in the inactivation of MPF during early C. elegans embryogenesis...
- Mochizuki K, Gorovsky M. A Dicer-like protein in Tetrahymena has distinct functions in genome rearrangement, chromosome segregation, and meiotic prophase. Genes Dev. 2005;19:77-89 pubmed..Dcl1p also is required for proper mitotic and meiotic segregation of micronuclear chromosomes and for normal chromosome alignment in meiotic prophase, suggesting that DCL1 has multiple functions in regulating chromosome dynamics...
- Boronat S, Campbell J. Mitotic Cdc6 stabilizes anaphase-promoting complex substrates by a partially Cdc28-independent mechanism, and this stabilization is suppressed by deletion of Cdc55. Mol Cell Biol. 2007;27:1158-71 pubmed..This demonstrates that the levels and timing of accumulation of Cdc6p in mitosis are appropriate for mediating the modulation of APC/Cdc20. ..
- Sleister H. Isolation and characterization of Saccharomyces cerevisiae mutants defective in chromosome transmission in an undergraduate genetics research course. Genetics. 2007;177:677-88 pubmed..Moreover, this course allowed students to experience scientific inquiry and was influential for students as they considered future endeavors. ..
- Lee M, Bachant J. SUMO modification of DNA topoisomerase II: trying to get a CENse of it all. DNA Repair (Amst). 2009;8:557-68 pubmed publisher..In closing, however, we will evaluate two possible interpretations: one in which SUMO promotes enzyme turnover, and a second in which SUMO acts as a localization tag for topo II chromosome trafficking. ..