Genomes and Genes
Experts and Doctors on mitochondria in United States
Locale: United States
Publications720 found, 100 shown here
- Gogada R, Yadav N, Liu J, Tang S, Zhang D, Schneider A, et al. Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. J Biol Chem. 2013;288:368-81 pubmed publisher..These findings suggest that the constitutively overexpressed Bim may function as a prosurvival molecule in epithelial cancer cells, and phosphorylation and association with Bcl-xL/Mcl-1 block its proapoptotic functions. ..
- Mavrianos J, Berkow E, Desai C, Pandey A, Batish M, Rabadi M, et al. Mitochondrial two-component signaling systems in Candida albicans. Eukaryot Cell. 2013;12:913-22 pubmed publisher..albicans possesses a two-component response regulator protein that has survived in mitochondria and regulates a subset of genes whose functions are associated with the oxidative stress response and programmed cell death (apoptosis). ..
- Shirakabe A, Fritzky L, Saito T, Zhai P, Miyamoto S, Gustafsson Ã, et al. Evaluating mitochondrial autophagy in the mouse heart. J Mol Cell Cardiol. 2016;92:134-9 pubmed publisher..In summary, the level of mitochondrial autophagy in the adult heart can be evaluated with intravenous injection of AAV-Mito-Keima and AAV-Lamp1-YFP and confocal microscopic analyses. ..
- Gondi C, Kandhukuri N, Dinh D, Gujrati M, Rao J. Down-regulation of uPAR and uPA activates caspase-mediated apoptosis and inhibits the PI3K/AKT pathway. Int J Oncol. 2007;31:19-27 pubmed..Our studies provide evidence for the presence of a feedback response of the uPAR-uPA system indicative of the multifaceted role of uPAR, and also the therapeutic potential of simultaneously targeting uPAR and uPA in cancer patients. ..
- Chang H, Wu R, Shang M, Sato T, Chen C, Shapiro J, et al. Reduction in mitochondrial iron alleviates cardiac damage during injury. EMBO Mol Med. 2016;8:247-67 pubmed publisher..Overall, our findings suggest that mitochondrial iron contributes to cardiac ischemic damage, and may be a novel therapeutic target against ischemic heart disease. ..
- Yang M, Trumpower B. Deletion of QCR6, the gene encoding subunit six of the mitochondrial cytochrome bc1 complex, blocks maturation of cytochrome c1, and causes temperature-sensitive petite growth in Saccharomyces cerevisiae. J Biol Chem. 1994;269:1270-5 pubmed..This is the first example where mutation of a subunit within the bc1 complex blocks maturation of cytochrome c1. ..
- Koybasi S, Senkal C, Sundararaj K, Spassieva S, Bielawski J, Osta W, et al. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem. 2004;279:44311-9 pubmed..In conclusion, this study demonstrates, for the first time, a biological role for LAG1 and C18-ceramide in the regulation of growth of HNSCC. ..
- Gu Y, Gordon D, Amutha B, Pain D. A GTP:AMP phosphotransferase, Adk2p, in Saccharomyces cerevisiae. Role of the C terminus in protein folding/stabilization, thermal tolerance, and enzymatic activity. J Biol Chem. 2005;280:18604-9 pubmed
- Holyoak T, Sullivan S, Nowak T. Structural insights into the mechanism of PEPCK catalysis. Biochemistry. 2006;45:8254-63 pubmed..The ordering of the mobile active site lid in the PEPCK-Mn2+-malonate-Mn2+ GDP complex yields the first observation of this structural feature and provides additional insight into the mechanism of phosphoryl transfer. ..
- Zhu H, Cao Z, Zhang L, Trush M, Li Y. Glutathione and glutathione-linked enzymes in normal human aortic smooth muscle cells: chemical inducibility and protection against reactive oxygen and nitrogen species-induced injury. Mol Cell Biochem. 2007;301:47-59 pubmed
- Mattingly K, Ivanova M, Riggs K, Wickramasinghe N, Barch M, Klinge C. Estradiol stimulates transcription of nuclear respiratory factor-1 and increases mitochondrial biogenesis. Mol Endocrinol. 2008;22:609-22 pubmed..Knockdown of NRF-1 blocked E(2) stimulation of mitochondrial biogenesis and activity, indicating a mechanism by which estrogens regulate mitochondrial function by increasing NRF-1 expression. ..
- Gybina A, Prohaska J. Fructose-2,6-bisphosphate is lower in copper deficient rat cerebellum despite higher content of phosphorylated AMP-activated protein kinase. Exp Biol Med (Maywood). 2008;233:1262-70 pubmed publisher..Furthermore, other metabolite data suggest that glycolysis may actually be blunted, since levels of glucose and glucose-6-phosphate were higher in Cu- cerebella than controls. ..
- Choi D, Liu M, Hunter R, Cass W, Pandya J, Sullivan P, et al. Striatal neuroinflammation promotes Parkinsonism in rats. PLoS ONE. 2009;4:e5482 pubmed publisher..These results implicate neuroinflammation-induced S-nitrosylation/nitration of mitochondrial complex I in mitochondrial malfunction and subsequent degeneration of the nigral dopamine neurons. ..
- Sauerbeck A, Gao J, Readnower R, Liu M, Pauly J, Bing G, et al. Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury. Exp Neurol. 2011;227:128-35 pubmed publisher..These studies provide further support for the use of PPAR ligands, specifically Pioglitazone, for neuroprotection. ..
- Calvetti D, Somersalo E. Ménage à trois: the role of neurotransmitters in the energy metabolism of astrocytes, glutamatergic, and GABAergic neurons. J Cereb Blood Flow Metab. 2012;32:1472-83 pubmed publisher..At inhibitory steady state, characterized by high rate of GABA release, there is elevated oxidative activity in astrocyte, not in response to specific energetic needs. ..
- Liu Z, Lanford R, Mueller S, Gerhard G, Luscieti S, Sanchez M, et al. Siderophore-mediated iron trafficking in humans is regulated by iron. J Mol Med (Berl). 2012;90:1209-21 pubmed publisher..These observations provide a new and an unanticipated mechanism by which iron regulates its intracellular trafficking. ..
- Perl A, Hanczko R, Doherty E. Assessment of mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus. Methods Mol Biol. 2012;900:61-89 pubmed publisher..Activation of the mammalian target of rapamycin (mTOR) has recently emerged as a key sensor of MHP and mediator of enhanced Ca(2+) flux in lupus T cells. ..
- Singh H, Li M, Hall L, Chen S, Sukur S, Lu R, et al. MaxiK channel interactome reveals its interaction with GABA transporter 3 and heat shock protein 60 in the mammalian brain. Neuroscience. 2016;317:76-107 pubmed publisher..The interaction of MaxiK channel with GAT3 opens the possibility of a role of MaxiK channel in GABA homeostasis and signaling. ..
- Ding L, Wang H, Lang W, Xiao L. Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway. J Biol Chem. 2002;277:35305-13 pubmed..Taken together, our findings suggest an important role for PKC-epsilon in regulating survival of lung cancer cells. ..
- Wakade C, Khan M, De Sevilla L, Zhang Q, Mahesh V, Brann D. Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase. Endocrinology. 2008;149:367-79 pubmed
- Su K, Banker G, Bourdette D, Forte M. Axonal degeneration in multiple sclerosis: the mitochondrial hypothesis. Curr Neurol Neurosci Rep. 2009;9:411-7 pubmed..In addition, the role of mitochondria as therapeutic targets for neuroprotection in MS is addressed. ..
- Li Y, Bondada V, Joshi A, Geddes J. Calpain 1 and Calpastatin expression is developmentally regulated in rat brain. Exp Neurol. 2009;220:316-9 pubmed publisher..The inverse relationship of calpain 1 and caspase 3 levels during CNS development is consistent with the shift from caspase-dependent to caspase-independent cell death mechanisms following CNS injury in neonatal vs. adult rat brain. ..
- Trotter P, Hagerman R, Voelker D. A yeast strain defective in oleic acid utilization has a mutation in the RML2 gene. Biochim Biophys Acta. 1999;1438:223-38 pubmed
- Liu Y, Jetton T, Leahy J. beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats. J Biol Chem. 2002;277:39163-8 pubmed
- Eng C, Kiuru M, Fernandez M, Aaltonen L. A role for mitochondrial enzymes in inherited neoplasia and beyond. Nat Rev Cancer. 2003;3:193-202 pubmed..Understanding this link between inherited cancer syndromes and neurological disease could provide further insights into the mechanisms by which mitochondrial deficiencies lead to tumour development. ..
- Jadus M, Chen Y, Boldaji M, Delgado C, Sanchez R, Douglass T, et al. Human U251MG glioma cells expressing the membrane form of macrophage colony-stimulating factor (mM-CSF) are killed by human monocytes in vitro and are rejected within immunodeficient mice via paraptosis that is associated with increased expression of. Cancer Gene Ther. 2003;10:411-20 pubmed..This study shows that human gliomas transduced with mM-CSF have the potential to be used as a safe live tumor cell vaccine. ..
- Holcroft N. A molecular analysis of the interrelationships of tetraodontiform fishes (Acanthomorpha: Tetraodontiformes). Mol Phylogenet Evol. 2005;34:525-44 pubmed..Many of the intrafamilial relationships recovered from the molecular data presented here corroborate previous morphological hypotheses...
- Sedensky M, Morgan P. Mitochondrial respiration and reactive oxygen species in C. elegans. Exp Gerontol. 2006;41:957-67 pubmed..Taken as a group, these mutant strains indicate that metabolic rate, per se, only affects longevity indirectly. Mutations causing lowered metabolic rate potential are capable of decreasing or increasing longevity. ..
- Kao C, Read L. Targeted depletion of a mitochondrial nucleotidyltransferase suggests the presence of multiple enzymes that polymerize mRNA 3' tails in Trypanosoma brucei mitochondria. Mol Biochem Parasitol. 2007;154:158-69 pubmed..Together, these data suggest that multiple nucleotidyltransferases act on mitochondrial mRNA 3' ends, and that these enzymes are somewhat redundant and subject to complex regulation. ..
- Perl A. The pathogenesis of transaldolase deficiency. IUBMB Life. 2007;59:365-73 pubmed..Delineation of the cell type-specific role that TAL plays in the PPP and cell death signal processing will be critical for understanding the pathogenesis of TAL deficiency. ..
- Giguere C, Covington M, Schnellmann R. Mitochondrial calpain 10 activity and expression in the kidney of multiple species. Biochem Biophys Res Commun. 2008;366:258-62 pubmed..These results provide evidence that several previously postulated splice variants of calpain 10 are localized to the mitochondria in kidneys of rabbits, rats, and mice. ..
- Lobo G, Isken A, Hoff S, Babino D, von Lintig J. BCDO2 acts as a carotenoid scavenger and gatekeeper for the mitochondrial apoptotic pathway. Development. 2012;139:2966-77 pubmed publisher..Thus, our study identifying BCDO2 as a crucial protective component against oxidative stress establishes this enzyme as mitochondrial carotenoid scavenger and a gatekeeper of the intrinsic apoptotic pathway. ..
- Schimmel B, Berbusse G, Naylor K. Mitochondrial fission and fusion in Dictyostelium discoideum: a search for proteins involved in membrane dynamics. BMC Res Notes. 2012;5:505 pubmed publisher..This work contributes to our overall understanding of mitochondrial dynamics and ultimately will provide additional insight into mitochondrial disease. ..
- Nath K, Grande J, Croatt A, Likely S, Hebbel R, Enright H. Intracellular targets in heme protein-induced renal injury. Kidney Int. 1998;53:100-11 pubmed..The presence of TUNEL-positive cells in the distal nephron but not at proximal sites in vivo underscores the increasing appreciation of the distinct responses of these nephron sites to nephrotoxic insults. ..
- Jiang J, Ghosh P, Kulp S, Sugimoto Y, Liu S, Czekajewski J, et al. Effects of gossypol on O2 consumption and CO2 production in human prostate cancer cells. Anticancer Res. 2002;22:1491-6 pubmed..0 microM. The inhibitory action of GP on O2 consumption/CO2 production of PC3 cells may be due to disruption of oxidative phosphorylation by inhibition of mitochondrial succinic dehydrogenase. ..
- Yi X, Yin X, Dong Z. Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed. J Biol Chem. 2003;278:16992-9 pubmed..Critical steps blocked by Bcl-2 included tBid insertion, Bax translocation, and Bax/Bak oligomerization in the mitochondrial membranes. ..
- Pigino G, Morfini G, Pelsman A, Mattson M, Brady S, Busciglio J. Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci. 2003;23:4499-508 pubmed..These findings suggest that mutations in PS1 may compromise neuronal function by affecting GSK-3 activity and kinesin-I-based motility. ..
- Sandberg E, Sayeski P. Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. J Biol Chem. 2004;279:34547-52 pubmed..Furthermore, this report identifies Jak2 as a potential therapeutic target in vascular diseases in which vascular smooth muscle cell apoptosis contributes to pathological progression. ..
- Jolly R, Goldstein K, Wei T, Gao H, Chen P, Huang S, et al. Pooling samples within microarray studies: a comparative analysis of rat liver transcription response to prototypical toxicants. Physiol Genomics. 2005;22:346-55 pubmed..An individual animal approach becomes more valuable when the overall expression response is subtle and/or when associating expression data to variable phenotypic responses. ..
- Newhall K, Criniti A, Cheah C, Smith K, Kafer K, Burkart A, et al. Dynamic anchoring of PKA is essential during oocyte maturation. Curr Biol. 2006;16:321-7 pubmed..However, during the early minutes of maturation, type II PKA moves from cytoplasmic sites to the mitochondria, where it associates with AKAP1, and this is shown to be essential for maturation to continue irreversibly. ..
- Brown L, Longacre M, Hasan N, Kendrick M, Stoker S, MacDonald M. Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line. J Biol Chem. 2009;284:35359-67 pubmed publisher..The maintenance of robust insulin secretion after lowering expression of either one of these malic enzymes is consistent with the redundancy of pathways of pyruvate cycling and/or cytosolic NADPH production in insulinoma cells...
- Kisiela D, Aulik N, Atapattu D, Czuprynski C. N-terminal region of Mannheimia haemolytica leukotoxin serves as a mitochondrial targeting signal in mammalian cells. Cell Microbiol. 2010;12:976-87 pubmed publisher..coli. These findings provide a new evidence for the importance of the N-terminal region in addressing certain RTX toxins to mitochondria. ..
- Arany I, Clark J, Ember I, Juncos L. Epigenetic modifiers exert renal toxicity through induction of p66shc. Anticancer Res. 2011;31:3267-71 pubmed..Knockdown or mutation of the cytochrome c binding site of p66shc attenuated ROS production and cell injury. Therapeutic means that interfere with induction of p66shc may ameliorate renal toxicity of those epigenetic modifiers. ..
- Budhraja A, Gao N, Zhang Z, Son Y, Cheng S, Wang X, et al. Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo. Mol Cancer Ther. 2012;11:132-42 pubmed publisher..Attenuation of tumor growth in U937 xenografts by apigenin raises the possibility that apigenin may have clinical implications and can be further tested for incorporating in leukemia treatment regimens. ..
- Scholl K, Allen J, Leendertz F, Chapman C, Reed D. Variable microsatellite loci for population genetic analysis of Old World monkey lice (Pedicinus sp.). J Parasitol. 2012;98:930-7 pubmed publisher..Because direct host-to-host contact is usually required for lice to move among hosts, these lice could be useful for identification and study of behavioral interactions between primate species...
- Gulde P, Christen L, Brown S, Williams N. Three distinct isoforms of ATP synthase subunit c are expressed in T. brucei and assembled into the mitochondrial ATP synthase complex. PLoS ONE. 2013;8:e54039 pubmed publisher..Although multiple subunit c genes have been found in other organisms, they produce identical polypeptides and the finding of significant differences in the mature proteins is unique to T. brucei. ..
- Han S, El Oussini H, Scekic Zahirovic J, Vibbert J, Cottee P, Prasain J, et al. VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans. PLoS Genet. 2013;9:e1003738 pubmed publisher..Abnormalities in energy metabolism of ALS patients may thus constitute a compensatory mechanism counterbalancing skeletal muscle mitochondrial dysfunction. ..
- Meiser J, Delcambre S, Wegner A, JÃ¤ger C, Ghelfi J, d Herouel A, et al. Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiol Dis. 2016;89:112-25 pubmed publisher..Our work reveals metabolic alterations leading to increased cellular instability and identifies potential new intervention points that can further be studied in the light of novel translational medicine approaches. ..
- Fenouille N, Bassil C, Ben Sahra I, Benajiba L, Alexe G, Ramos A, et al. The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia. Nat Med. 2017;23:301-313 pubmed publisher..Targeting CKMT1 is thus a promising therapeutic strategy for this EVI1-driven AML subtype that is highly resistant to current treatment regimens. ..
- Ettinger R, Ismail R, DeLuca H. cDNA cloning and characterization of a vitamin D3 hydroxylase-associated protein. J Biol Chem. 1994;269:176-82 pubmed..VDHAP is a novel chick kidney-specific inner membrane protein of mitochondria, which associates with a fraction of the 1,25-dihydroxyvitamin D3-24R-hydroxylase and 25-hydroxyvitamin D3-1 alpha-hydroxylase. ..
- Stribinskis V, Gao G, Ellis S, Martin N. Rpm2, the protein subunit of mitochondrial RNase P in Saccharomyces cerevisiae, also has a role in the translation of mitochondrially encoded subunits of cytochrome c oxidase. Genetics. 2001;158:573-85 pubmed..Moreover, there is a synthetic lethal interaction between the disruption of this novel respiratory function and the loss of wild-type mtDNA. This synthetic interaction explains why a complete deletion of RPM2 is lethal. ..
- Deng Y, Kohlwein S, Mannella C. Fasting induces cyanide-resistant respiration and oxidative stress in the amoeba Chaos carolinensis: implications for the cubic structural transition in mitochondrial membranes. Protoplasma. 2002;219:160-7 pubmed
- Joshi S, Francis C, Silverman D, Sahni S. Nuclear factor kappa B protects against host cell apoptosis during Rickettsia rickettsii infection by inhibiting activation of apical and effector caspases and maintaining mitochondrial integrity. Infect Immun. 2003;71:4127-36 pubmed..Targeted inhibition of NF-kappa B may therefore be exploited to enhance the clearance of infections with R. rickettsii and other intracellular pathogens with similar survival strategies...
- Bijur G, Jope R. Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation. J Neurochem. 2003;87:1427-35 pubmed..These results demonstrate that signals emanating from plasma membrane receptors or generated by stress rapidly modulate Akt and glycogen synthase kinase-3beta in mitochondria. ..
- Altuve A, Wang L, Benson D, Rivera M. Mammalian mitochondrial and microsomal cytochromes b(5) exhibit divergent structural and biophysical characteristics. Biochem Biophys Res Commun. 2004;314:602-9 pubmed..The biophysical properties characteristic of the OM proteins may be important in facilitating the two functions proposed for them so far, reduction of ascorbate radical and stimulation of androgen synthesis. ..
- Zhu H, Piletz J. Association between I(2) binding sites and monoamine oxidase-B activity in platelets. Ann N Y Acad Sci. 2003;1009:347-52 pubmed..61, P = 0.0016) among 24 human subjects. Nevertheless, the variance in MAO-B activity cannot be completely accounted for in relation to I(2) sites. Therefore, I(2) density and MAO-B activity are only weakly correlated in platelets. ..
- Vaena De Avalos S, Su X, Zhang M, Okamoto Y, Dowhan W, Hannun Y. The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae. J Biol Chem. 2005;280:7170-7 pubmed..This study provides the first evidence for the mechanism of in vivo activation and function of Isc1p. A model with endogenous PG/CL as the in vivo activator of Isc1p is proposed. ..
- Kitatani K, Idkowiak Baldys J, Bielawski J, Taha T, Jenkins R, Senkal C, et al. Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. J Biol Chem. 2006;281:36793-802 pubmed
- Si Y, Palani S, Jayaraman A, Lee K. Effects of forced uncoupling protein 1 expression in 3T3-L1 cells on mitochondrial function and lipid metabolism. J Lipid Res. 2007;48:826-36 pubmed..Together, our results suggest that the reduction in intracellular lipid by constitutive expression of UCP1 reflects a downregulation of fat synthesis rather than an upregulation of fatty acid oxidation. ..
- Ding M, Butler C, Saracco S, Fox T, Godard F, di Rago J, et al. Introduction of cytochrome b mutations in Saccharomyces cerevisiae by a method that allows selection for both functional and non-functional cytochrome b proteins. Biochim Biophys Acta. 2008;1777:1147-56 pubmed publisher..This is the first time mutations have been created for three of the loci presented here, and nine of the resulting mutants have never been described before. ..
- Liu Y, Villamena F, Sun J, Wang T, Zweier J. Esterified trityl radicals as intracellular oxygen probes. Free Radic Biol Med. 2009;46:876-83 pubmed publisher..This study demonstrates that these esterified trityl radicals can function as effective EPR oximetry probes measuring intracellular O2 concentration and consumption. ..
- Ye B, Kroboth S, Pu J, Sims J, Aggarwal N, McNally E, et al. Molecular identification and functional characterization of a mitochondrial sulfonylurea receptor 2 splice variant generated by intraexonic splicing. Circ Res. 2009;105:1083-93 pubmed publisher..Cardioprotective pathways may involve a mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel but its composition is not fully understood...
- Xu J, Seo A, Vorobyeva D, Carter C, Anton S, Lezza A, et al. Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats. PLoS ONE. 2010;5:e10572 pubmed publisher..Selected antioxidants and specific combinations of nutritional compounds could target many biochemical pathways that affect both oxidative stress and mitochondrial function and, thereby, preserve or enhance physical performance...
- Roos C, Hagler M, Zhang B, Oehler E, Arghami A, Miller J. Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice. Am J Physiol Heart Circ Physiol. 2013;305:H1428-39 pubmed publisher..Furthermore, although MnSOD does not result in overt cardiovascular dysfunction with aging, compensatory transcriptional responses to MnSOD deficiency appear to be tissue specific. ..
- Corum D, Tsichlis P, Muise Helmericks R. AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. FASEB J. 2014;28:395-407 pubmed publisher..This correlates with an ~1.5-fold decrease in mitochondrial Cox IV expression. Our studies suggest that Akt3 is a regulator of mitochondrial dynamics in the vasculature via regulation of CRM-1-dependent nuclear export. ..
- Liu W, Beck B, Vaidya K, Nash K, Feeley K, Ballinger S, et al. Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis. Cancer Res. 2014;74:954-63 pubmed publisher..Since the downstream effects could be reversed using short hairpin RNA to KISS1 or PGC1?, these data appear to directly connect changes in mitochondria mass, cellular glucose metabolism, and metastasis. ..
- Lee H, Yoon Y. Transient contraction of mitochondria induces depolarization through the inner membrane dynamin OPA1 protein. J Biol Chem. 2014;289:11862-72 pubmed publisher..Our findings show that transient matrix contraction is a novel cellular mechanism regulating mitochondrial activity through the function of the inner membrane dynamin OPA1. ..
- Einat H, Yuan P, Manji H. Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders. Behav Brain Res. 2005;165:172-80 pubmed..Our study, therefore demonstrates that Bcl-2 may be a key factor in anxiety disorders and that its effects may possibly originate from its role in the mitochondria. ..
- Liu S, Bae Y, Leggas M, Daily A, Bhatnagar S, Miriyala S, et al. Pharmacologic properties of polyethylene glycol-modified Bacillus thiaminolyticus thiaminase I enzyme. J Pharmacol Exp Ther. 2012;341:775-83 pubmed publisher..These studies suggest that the mechanism of anticancer cytotoxicity of thiaminase requires acute depression of cellular respiration, whereas systemic toxicity is related to the duration of extracellular thiamine depletion...
- Gilkeson G, Mashmoushi A, Ruiz P, Caza T, Perl A, Oates J. Endothelial nitric oxide synthase reduces crescentic and necrotic glomerular lesions, reactive oxygen production, and MCP1 production in murine lupus nephritis. PLoS ONE. 2013;8:e64650 pubmed publisher..These results suggest that modulation of eNOS may be a novel therapeutic approach to treating lupus nephritis. ..
- Sakuragi S, Liu Q, Craig E. Interaction between the nucleotide exchange factor Mge1 and the mitochondrial Hsp70 Ssc1. J Biol Chem. 1999;274:11275-82 pubmed..The robust growth of the K108A/R213A MGE1 mutant suggests that the interaction between Mge1 and Ssc1 is tighter than required for function in vivo. ..
- Kruman I, Pedersen W, Springer J, Mattson M. ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis. Exp Neurol. 1999;160:28-39 pubmed..The mitochondrial dysfunction associated with Cu/Zn-SOD mutations may play an important role in disturbing calcium homeostasis and increasing oxyradical production, thereby increasing the vulnerability of MNs to excitotoxicity. ..
- Poulet F, Berardi M, Halliwell W, Hartman B, Auletta C, Bolte H. Development of hibernomas in rats dosed with phentolamine mesylate during the 24-month carcinogenicity study. Toxicol Pathol. 2004;32:558-66 pubmed..This study documents the previously unreported development of hibernomas in rats treated with phentolamine mesylate. ..
- Patel S, Sullivan P, Pandya J, Rabchevsky A. Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury. J Neurosci Res. 2009;87:130-140 pubmed publisher..Moreover, they indicate that combinatorial therapeutic approaches targeting different populations of mitochondria holds great potential in fostering neuroprotection after acute SCI. ..
- Chen Q, Paillard M, Gomez L, Ross T, Hu Y, Xu A, et al. Activation of mitochondrial ?-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion. Biochem Biophys Res Commun. 2011;415:533-8 pubmed publisher..Inhibition of calpains using MDL-28170 decreases cardiac injury by inhibiting both cytosolic calpains and mito-?-calpain during ischemia-reperfusion. ..
- Zhao X, Tian C, Puszyk W, Ogunwobi O, Cao M, Wang T, et al. OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma. Lab Invest. 2013;93:8-19 pubmed publisher..Our results provide new insights into the pathogenesis of HCC and suggest that OPA1 is a novel therapeutic target in patients with HCC. ..
- Jin Y, Yu Y, Gundemir S, Jo C, Cui M, Tieu K, et al. Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin. PLoS ONE. 2013;8:e57932 pubmed publisher..These results suggest that mHtt disrupts Nrf2 signaling which contributes to impaired mitochondrial dynamics and may enhance susceptibility to oxidative stress in STHdh(Q111/Q111) cells...
- Bauer J, Morrison B, Grane R, Jacobs B, Dabney S, Gamero A, et al. Effects of interferon beta on transcobalamin II-receptor expression and antitumor activity of nitrosylcobalamin. J Natl Cancer Inst. 2002;94:1010-9 pubmed..NO-Cbl inhibited tumor growth in vivo by activating the extrinsic apoptotic pathway. The increased expression of TC II-R induced by IFN-beta resulted in enhanced antitumor effects with NO-Cbl both in vitro and in vivo. ..
- Byrne E, Stout A, Gott J. Editing site recognition and nucleotide insertion are separable processes in Physarum mitochondria. EMBO J. 2002;21:6154-61 pubmed
- Ilangovan G, Osinbowale S, Bratasz A, Bonar M, Cardounel A, Zweier J, et al. Heat shock regulates the respiration of cardiac H9c2 cells through upregulation of nitric oxide synthase. Am J Physiol Cell Physiol. 2004;287:C1472-81 pubmed..On the basis of these results, we conclude that myocardial protection by hyperthermia occurs at least partly by the pathway of HSP90-mediated NO production, leading to subsequent attenuation of cellular respiration. ..
- Ryan C, Kao C, Sleve D, Read L. Biphasic decay of guide RNAs in Trypanosoma brucei. Mol Biochem Parasitol. 2006;146:68-77 pubmed..Overall, these results provide the first evidence for a gRNA-specific decay pathway. ..
- Taha T, Kitatani K, El Alwani M, Bielawski J, Hannun Y, Obeid L. Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J. 2006;20:482-4 pubmed..These studies for the first time implicate endogenous SK1 as an important survival enzyme in MCF-7 cells and link the biological consequences of knocking down the enzyme to its biochemical role as a regulator of sphingolipid metabolism. ..
- Zhang A, Sheftel A, Ponka P. The anemia of "haemoglobin-deficit" (hbd/hbd) mice is caused by a defect in transferrin cycling. Exp Hematol. 2006;34:593-8 pubmed..Therefore, the product of Sec15l1 is directly involved in vesicular trafficking, docking, fusing, and/or cargo delivery in erythroid precursors. ..
- Falk M, Kayser E, Morgan P, Sedensky M. Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans. Curr Biol. 2006;16:1641-5 pubmed..This work is the first to specifically implicate complex I-dependent oxidative phosphorylation function as a primary mediator of volatile anesthetic effect. ..