Genomes and Genes
Experts and Doctors on mitochondria in United Kingdom
Locale: United Kingdom
Publications149 found, 100 shown here
- Neame S, Rubin L, Philpott K. Blocking cytochrome c activity within intact neurons inhibits apoptosis. J Cell Biol. 1998;142:1583-93 pubmed..These data suggest that cytochrome c is an intrinsic but not limiting component of the neuronal apoptotic pathway. ..
- Hanrott K, Gudmunsen L, O Neill M, Wonnacott S. 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta. J Biol Chem. 2006;281:5373-82 pubmed
- Aguilera P, Barry T, Tovar J. Entamoeba histolytica mitosomes: organelles in search of a function. Exp Parasitol. 2008;118:10-6 pubmed..Identifying the protein complement of mitosomes will provide answers as to their biological significance and the reason(s) for their retention in this parasite. ..
- Williams R, Smith T, Cull B, Mottram J, Coombs G. ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major. PLoS Pathog. 2012;8:e1002695 pubmed publisher..The overall result of this is reduced virulence. ..
- Pienaar I, Elson J, Racca C, Nelson G, Turnbull D, Morris C. Mitochondrial abnormality associates with type-specific neuronal loss and cell morphology changes in the pedunculopontine nucleus in Parkinson disease. Am J Pathol. 2013;183:1826-1840 pubmed publisher..Our findings suggest an imbalance in the activity of key neuronal subgroups of the PPN in PD, potentially because of abnormal inhibitory activity and altered cholinergic outflow. ..
- Bogsch E, Sargent F, Stanley N, Berks B, Robinson C, Palmer T. An essential component of a novel bacterial protein export system with homologues in plastids and mitochondria. J Biol Chem. 1998;273:18003-6 pubmed..These findings suggest a central role for TatC-type proteins in the translocation of tightly folded proteins across a spectrum of biological membranes. ..
- Yang Z, Nielsen R, Goldman N, Pedersen A. Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics. 2000;155:431-49 pubmed..However, we encountered difficulties in estimating the precise distribution of omega among sites from real data sets. ..
- Telford M, Herniou E, Russell R, Littlewood D. Changes in mitochondrial genetic codes as phylogenetic characters: two examples from the flatworms. Proc Natl Acad Sci U S A. 2000;97:11359-64 pubmed
- Albury M, Affourtit C, Crichton P, Moore A. Structure of the plant alternative oxidase. Site-directed mutagenesis provides new information on the active site and membrane topology. J Biol Chem. 2002;277:1190-4 pubmed..These data are discussed in reference to the importance of both residues in the catalytic cycle of the AOX. ..
- Sun X, Bratton S, Butterworth M, MacFarlane M, Cohen G. Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein. J Biol Chem. 2002;277:11345-51 pubmed..Our data strongly suggest that the relative ratios of XIAP (and other inhibitor-of-apoptosis proteins) to active caspase-3 and Smac may dictate, in part, whether a cell exhibits a type I or type II phenotype. ..
- Lam D, Dickens D, Reid E, Loh S, Moisoi N, Martins L. MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins. Proc Natl Acad Sci U S A. 2009;106:11978-83 pubmed publisher..Additionally, we found decreased levels of this kinase in pancreatic cancer samples, suggesting a tumor suppressor role for MAP4K3 in pancreatic tumorigenesis. ..
- Mercer A, Copple I, Maggs J, O Neill P, Park B. The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials. J Biol Chem. 2011;286:987-96 pubmed publisher..36 ± 0.20 ?M and 11 ± 5%; and with succinylacetone, >100 ?M and 2 ± 5%). ..
- Alkhaldi A, Martinek J, Panicucci B, Dardonville C, ZÃkovÃ¡ A, de Koning H. Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei. Int J Parasitol Drugs Drug Resist. 2016;6:23-34 pubmed publisher..The results show that, in T. brucei, bisphosphonium compounds do not principally act on succinate dehydrogenase but on the mitochondrial FoF1 ATPase. ..
- Doig C, Fletcher R, Morgan S, McCabe E, Larner D, Tomlinson J, et al. 11Î²-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice. Endocrinology. 2017;158:1964-1976 pubmed publisher..These data reveal a novel mechanism in which increased 11Î²-HSD1 expression, in the context of GC excess and aging, impairs the molecular and metabolic function of BAT. ..
- Marsh S, Carter N, Dolce V, Iacobazzi V, Palmieri F. Chromosomal localization of the mitochondrial phosphate carrier gene PHC to 12q23. Genomics. 1995;29:814-5 pubmed
- Pallis M, Grundy M, Turzanski J, Kofler R, Russell N. Mitochondrial membrane sensitivity to depolarization in acute myeloblastic leukemia is associated with spontaneous in vitro apoptosis, wild-type TP53, and vicinal thiol/disulfide status. Blood. 2001;98:405-13 pubmed..It was concluded that in leukemia, TP53 and vicinal thiol/disulfide status are determinants of mitochondrial membrane sensitivity to depolarization, which is in turn associated with spontaneous apoptosis. ..
- Murphy M, Leuenberger D, Curran S, Oppliger W, Koehler C. The essential function of the small Tim proteins in the TIM22 import pathway does not depend on formation of the soluble 70-kilodalton complex. Mol Cell Biol. 2001;21:6132-8 pubmed
- Basselin M, Denise H, Coombs G, Barrett M. Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion. Antimicrob Agents Chemother. 2002;46:3731-8 pubmed
- Biagini G, Viriyavejakul P, O Neill P, Bray P, Ward S. Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria. Antimicrob Agents Chemother. 2006;50:1841-51 pubmed..The potential of targeting PfNDH2 as a chemotherapeutic strategy for drug development is discussed. ..
- Monné M, Robinson A, Boes C, Harbour M, Fearnley I, Kunji E. The mimivirus genome encodes a mitochondrial carrier that transports dATP and dTTP. J Virol. 2007;81:3181-6 pubmed..As the 1.2-Mb double-stranded DNA mimivirus genome is rich in A and T residues, we speculate that the virus is using this protein to target the host mitochondria as a source of deoxynucleotides for its replication. ..
- Matic I, Cocco S, Ferraina C, Martin Jimenez R, Florenzano F, Crosby J, et al. Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1. Pharmacol Res. 2016;103:56-68 pubmed publisher..These data suggest that in mammalian neurons mitochondria adapt to respiratory stress by upregulating IF1, which exerts a protective role by coordinating pro-survival cell mitophagy and bioenergetics resilience. ..
- Billups B, Forsythe I. Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses. J Neurosci. 2002;22:5840-7 pubmed..Without detectable thapsigargin-sensitive presynaptic calcium stores, we conclude that mitochondria are the major organelle regulating presynaptic calcium at central glutamatergic terminals. ..
- Murray A, Denis R, Speake B. Acyltransferase activities in the yolk sac membrane of the chick embryo. Lipids. 1999;34:929-35 pubmed..The results also suggest that the YSM has the capacity to perform simultaneously beta-oxidation at a high rate in order to provide energy for the lipid transfer process. ..
- Heath C, Windsor M, Wileman T. Aggresomes resemble sites specialized for virus assembly. J Cell Biol. 2001;153:449-55 pubmed
- Cleary S, Tan F, Nakrieko K, Thompson S, Mullineaux P, Creissen G, et al. Isolated plant mitochondria import chloroplast precursor proteins in vitro with the same efficiency as chloroplasts. J Biol Chem. 2002;277:5562-9 pubmed..Finally, we show that disruption of potential amphipathic helices in one presequence does not block import into pea mitochondria, indicating that other features are recognized. ..
- Saretzki G, Walter T, Atkinson S, Passos J, Bareth B, Keith W, et al. Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells. Stem Cells. 2008;26:455-64 pubmed..These results confirm earlier data obtained during mouse embryonic stem cell differentiation and are in accordance with evolutionary predictions. ..
- Ma H, Hagen F, Stekel D, Johnston S, Sionov E, Falk R, et al. The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation. Proc Natl Acad Sci U S A. 2009;106:12980-5 pubmed publisher..Our data thus demonstrate that the intracellular parasitism of macrophages is a key driver of a human disease outbreak, a finding that has significant implications for a wide range of other human pathogens. ..
- Divakaruni A, Humphrey D, Brand M. Fatty acids change the conformation of uncoupling protein 1 (UCP1). J Biol Chem. 2012;287:36845-53 pubmed publisher..Our results provide a framework for how fatty acids and nucleotides compete to regulate the activity of UCP1. ..
- Ogawa F, Murphy L, Malavasi E, O Sullivan S, Torrance H, Porteous D, et al. NDE1 and GSK3? Associate with TRAK1 and Regulate Axonal Mitochondrial Motility: Identification of Cyclic AMP as a Novel Modulator of Axonal Mitochondrial Trafficking. ACS Chem Neurosci. 2016;7:553-64 pubmed publisher..Our demonstration that they function together within mitochondrial trafficking complexes suggests that defective mitochondrial transport may be a contributory disease mechanism in some cases of psychiatric disorder. ..
- Allen N, Karadottir R, Attwell D. A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells. J Neurosci. 2005;25:848-59 pubmed..They also define a hierarchy of pool sizes for hippocampal energy stores and suggest that brain ATP production from glial lactate may not be significant in conditions of energy deprivation. ..
- Coatesworth W, Bolsover S. Spatially organised mitochondrial calcium uptake through a novel pathway in chick neurones. Cell Calcium. 2006;39:217-25 pubmed
- Hall A, Crawford C, Unwin R, Duchen M, Peppiatt Wildman C. Multiphoton imaging of the functioning kidney. J Am Soc Nephrol. 2011;22:1297-304 pubmed publisher..This study demonstrates that multiphoton microscopy of the isolated perfused kidney is a powerful technique for detailed imaging of cell structure and function in an intact organ. ..
- Jiggins F, Tinsley M. An ancient mitochondrial polymorphism in Adalis bipunctata linked to a sex-ratio-distorting bacterium. Genetics. 2005;171:1115-24 pubmed..We conclude that the fitness of these male killers may be negatively frequency dependent or different strains may be favored in different populations. These hypotheses await experimental confirmation. ..
- Ang S, Lu H. Deciphering structural and functional roles of individual disulfide bonds of the mitochondrial sulfhydryl oxidase Erv1p. J Biol Chem. 2009;284:28754-61 pubmed publisher..Thus, we provided the first experimental evidence of electron transfer between the shuttle and active site disulfides of Erv1p, and we propose that both intersubunit and intermolecular electron transfer can occur. ..
- ..Copper ions are specifically released from copper metallochaperones upon contact with their cognate cuproproteins and metal transfer is thought to proceed by ligand substitution. ..
- Holmes A, Mühlen S, Roe A, Dean P. The EspF effector, a bacterial pathogen's Swiss army knife. Infect Immun. 2010;78:4445-53 pubmed publisher..This review focuses on the activities of EspF within the host cell and discusses recent findings and molecular insights relating to the virulence functions of this fascinating bacterial effector. ..
- Fiorillo M, Sotgia F, Sisci D, Cappello A, Lisanti M. Mitochondrial "power" drives tamoxifen resistance: NQO1 and GCLC are new therapeutic targets in breast cancer. Oncotarget. 2017;8:20309-20327 pubmed publisher..More specifically, higher levels of NQO1 mRNA strongly predict patient relapse in high-risk ER(+) breast cancer patients receiving endocrine therapy (mostly tamoxifen; H.R. > 2.15; p = 0.007). ..
- Vial S, Lu H, Allen S, Savory P, Thornton D, Sheehan J, et al. Assembly of Tim9 and Tim10 into a functional chaperone. J Biol Chem. 2002;277:36100-8 pubmed..These data demonstrate that the individual subunits can exist as independent, dynamically self-associating proteins. Assembly into the thermodynamically stable hexameric complex is necessary for the TIM10 chaperone function. ..
- Ciccarelli O, Toosy A, De Stefano N, Wheeler Kingshott C, Miller D, Thompson A. Assessing neuronal metabolism in vivo by modeling imaging measures. J Neurosci. 2010;30:15030-3 pubmed publisher..Lower residual variance in NAA, reflecting reduced mitochondrial metabolism, was associated with greater clinical disability in MS, independent of structural damage. ..
- Selak M, Armour S, MacKenzie E, Boulahbel H, Watson D, Mansfield K, et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell. 2005;7:77-85 pubmed..These results suggest a mechanistic link between SDH mutations and HIF-1alpha induction, providing an explanation for the highly vascular tumors that develop in the absence of VHL mutations. ..
- Martins L, Morrison A, Klupsch K, Fedele V, Moisoi N, Teismann P, et al. Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol. 2004;24:9848-62 pubmed
- Havelda Z, Maule A. Complex spatial responses to cucumber mosaic virus infection in susceptible Cucurbita pepo cotyledons. Plant Cell. 2000;12:1975-86 pubmed..The experiments showed that virus infection induced immediate and subsequent changes in gene expression by the host and that the infection has the potential to give advance signaling of the imminent infection. ..
- Caton P, Nayuni N, Murch O, Corder R. Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase. Life Sci. 2009;84:738-44 pubmed publisher..These results indicate that decreases in hepatic PEPCK-M play a key role in the manifestation of hyperlactatemia and hypoglycemia in endotoxemia. ..
- Morgan G, Goulding D, Field M. The single dynamin-like protein of Trypanosoma brucei regulates mitochondrial division and is not required for endocytosis. J Biol Chem. 2004;279:10692-701 pubmed..The evolutionary implications of these findings are discussed. ..
- Owens T, Foster F, Valentijn A, Gilmore A, Streuli C. Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization. J Biol Chem. 2010;285:1081-8 pubmed publisher..Moreover, switching the function of proteins from anti- to proapoptotic forms may be a common theme in the efficient execution of cell death. ..
- Siegesmund M, Hehl A, van der Giezen M. Mitosomes in trophozoites and cysts of the reptilian parasite Entamoeba invadens. Eukaryot Cell. 2011;10:1582-5 pubmed publisher..Here, we show that the distantly related reptilian pathogen Entamoeba invadens contains mitosomes, in both trophozoites and cysts, suggesting all Entamoeba species contain these organelles. ..
- Harris J, Attwell D. The energetics of CNS white matter. J Neurosci. 2012;32:356-71 pubmed publisher..Finally, we show that mitochondria in optic nerve axons could sustain measured firing rates with a plausible density of glucose transporters in the nodal membrane, without the need for energy transfer from oligodendrocytes. ..
- Kowald A, Kirkwood T. Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging. Proc Natl Acad Sci U S A. 2014;111:2972-7 pubmed publisher..Computer simulations show the mechanism to be compatible with the available data from short- and long-lived mammalian species. ..
- Allen S, Lu H, Thornton D, Tokatlidis K. Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10. J Biol Chem. 2003;278:38505-13 pubmed..Taken together these data reveal this specific intramolecular disulfide bonding as the crucial mechanism for Tim10 folding and show that the inner cysteine pair has a more prominent role in this process. ..
- Boonrungsiman S, Gentleman E, Carzaniga R, Evans N, McComb D, Porter A, et al. The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation. Proc Natl Acad Sci U S A. 2012;109:14170-5 pubmed publisher..These observations may have important implications in deciphering both how normal bone forms and in understanding pathological mineralization. ..
- Scott T, Kronsten V, Hughes R, Shawcross D. Pathophysiology of cerebral oedema in acute liver failure. World J Gastroenterol. 2013;19:9240-55 pubmed publisher..At present, there is no fully efficacious therapy for cerebral oedema other than liver transplantation and this reflects our incomplete knowledge of the precise mechanisms underlying this process which remain largely unknown. ..
- Bond M, Murphy G, Bennett M, Newby A, Baker A. Tissue inhibitor of metalloproteinase-3 induces a Fas-associated death domain-dependent type II apoptotic pathway. J Biol Chem. 2002;277:13787-95 pubmed..Taken together, these results indicate that TIMP-3 overexpression induces a type II apoptotic pathway initiated via a Fas-associated death domain-dependent mechanism. ..
- MacFarlane M, Merrison W, Bratton S, Cohen G. Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. J Biol Chem. 2002;277:36611-6 pubmed..Thus, in addition to its well characterized role in inhibiting caspase activity, XIAP may also protect cells from inadvertent mitochondrial damage by targeting pro-apoptotic molecules for proteasomal degradation. ..
- Wang P, Valentijn A, Gilmore A, Streuli C. Early events in the anoikis program occur in the absence of caspase activation. J Biol Chem. 2003;278:19917-25 pubmed..Moreover, although the conformational changes in Bax are rapid and synchronous, the subsequent events occur stochastically and with considerable delays. ..
- Abramov A, Fraley C, Diao C, Winkfein R, Colicos M, Duchen M, et al. Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death. Proc Natl Acad Sci U S A. 2007;104:18091-6 pubmed..These results demonstrate a crucial role played by polyP in mitochondrial function of mammalian cells. ..
- Hardie D. Sensing of energy and nutrients by AMP-activated protein kinase. Am J Clin Nutr. 2011;93:891S-6 pubmed publisher..Most of these agents activate AMPK because they inhibit mitochondrial function. ..
- Osellame L, Blacker T, Duchen M. Cellular and molecular mechanisms of mitochondrial function. Best Pract Res Clin Endocrinol Metab. 2012;26:711-23 pubmed publisher..Mitochondrial dysfunction is implicated in metabolic and age related disorders, neurodegenerative diseases and ischemic injury in heart and brain. ..
- Fuchs R, Kopischke M, Klapprodt C, Hause G, Meyer A, SchwarzlÃ¤nder M, et al. Immobilized Subpopulations of Leaf Epidermal Mitochondria Mediate PENETRATION2-Dependent Pathogen Entry Control in Arabidopsis. Plant Cell. 2016;28:130-45 pubmed publisher..Moreover, live-cell imaging shows that mitochondria arrested at these domains exhibit a pathogen-induced redox imbalance, which may lead to the production of intracellular signals. ..
- Pryde J, Walker A, Rossi A, Hannah S, Haslett C. Temperature-dependent arrest of neutrophil apoptosis. Failure of Bax insertion into mitochondria at 15 degrees C prevents the release of cytochrome c. J Biol Chem. 2000;275:33574-84 pubmed..Bax insertion was only sensitive to zVAD-fmk when added at the start of the 15 degrees C culture period, suggesting that a cytoplasmic substrate of the effector caspases may mediate in the mechanism of Bax insertion into mitochondria. ..
- Pracharoenwattana I, Cornah J, Smith S. Arabidopsis peroxisomal citrate synthase is required for fatty acid respiration and seed germination. Plant Cell. 2005;17:2037-48 pubmed..We conclude that citrate is exported from the peroxisome during fatty acid respiration, whereas in yeast, acetylcarnitine is exported. ..
- Grosskreutz J, Haastert K, Dewil M, Van Damme P, Callewaert G, Robberecht W, et al. Role of mitochondria in kainate-induced fast Ca2+ transients in cultured spinal motor neurons. Cell Calcium. 2007;42:59-69 pubmed..This may exert deleterious effects in motor neuron disease where mitochondrial function is thought to be compromised. ..
- Murray A. Oxygen delivery and fetal-placental growth: beyond a question of supply and demand?. Placenta. 2012;33 Suppl 2:e16-22 pubmed publisher..Much remains unknown about the coordinated metabolic response of the fetal-placental unit to chronic hypoxia and oxidative stress, but it would appear to be more than a simple question of supply and demand. ..
- Gibson B, Daley D, Williams D. Structural elucidation of N-terminal post-translational modifications by mass spectrometry: application to chicken enolase and the alpha- and beta-subunits of bovine mitochondrial F1-ATPase. Anal Biochem. 1988;169:217-26 pubmed..These data showed the N-terminus to be frayed with N-terminal sequences beginning in pyro-Glu-Ala-Ser, Gln-Ala-Ser, Glu-Ala-Ser, Ala-Ser, and Ser but with no N-acetyl-Ser as was previously thought. ..
- Esposti M, Erler J, Hickman J, Dive C. Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity. Mol Cell Biol. 2001;21:7268-76 pubmed..Thus, Bid is likely to be involved in the transport and recycling of mitochondrial phospholipids. We discuss how this new role of Bid may relate to its proapoptotic action. ..
- Couto N, Malys N, Gaskell S, Barber J. Partition and turnover of glutathione reductase from Saccharomyces cerevisiae: a proteomic approach. J Proteome Res. 2013;12:2885-94 pubmed publisher..Surprisingly, the second AUG appears to be responsible for most of the cellular Glr1. This is the first report of protein turnover measurements of a low-abundance protein distributed in different compartments of a eukaryotic cell. ..
- Randle S, Laman H. F-box protein interactions with the hallmark pathways in cancer. Semin Cancer Biol. 2016;36:3-17 pubmed publisher..We suggest six highly interconnected FBPs affecting multiple cancer hallmarks, which may prove sensible candidates for therapeutic intervention. ..
- Voronina S, Barrow S, Gerasimenko O, Petersen O, Tepikin A. Effects of secretagogues and bile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating DeltaPsim. J Biol Chem. 2004;279:27327-38 pubmed..Our experiments demonstrate that physiological concentrations of secretagogues and pathologically relevant concentrations of bile acids trigger mitochondrial depolarization in pancreatic acinar cells. ..
- Evans A, Mustard K, Wyatt C, Peers C, Dipp M, Kumar P, et al. Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells?. J Biol Chem. 2005;280:41504-11 pubmed..Thus, metabolic sensing by AMP-activated protein kinase may mediate chemotransduction by hypoxia. ..
- Lloyd R, Lee J, Alberio R, Bowles E, Ramalho Santos J, Campbell K, et al. Aberrant nucleo-cytoplasmic cross-talk results in donor cell mtDNA persistence in cloned embryos. Genetics. 2006;172:2515-27 pubmed..Consequently, nucleo-mitochondrial interaction following nuclear transfer is out of sequence as the onset of mitochondrial replication is a postimplantation event. ..
- Finkemeier I, Laxa M, Miguet L, Howden A, Sweetlove L. Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis. Plant Physiol. 2011;155:1779-90 pubmed publisher..Our results demonstrate that Lys acetylation also occurs on proteins outside the nucleus in Arabidopsis (Arabidopsis thaliana) and that Lys acetylation could be important in the regulation of key metabolic enzymes. ..
- Masgras I, Carrera S, De Verdier P, Brennan P, Majid A, Makhtar W, et al. Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. J Biol Chem. 2012;287:9845-54 pubmed publisher..This suggests that selective up-regulation of p21 in cancer cells could be a successful therapeutic intervention for sarcomas and tumors with lower resistance to mitochondrial oxidative damage, regardless of p53 status. ..
- Purdue P, Allsop J, Isaya G, Rosenberg L, Danpure C. Mistargeting of peroxisomal L-alanine:glyoxylate aminotransferase to mitochondria in primary hyperoxaluria patients depends upon activation of a cryptic mitochondrial targeting sequence by a point mutation. Proc Natl Acad Sci U S A. 1991;88:10900-4 pubmed..These results are discussed with reference to the AGT targeting defect in primary hyperoxaluria and also in relation to the highly unusual species specificity of subcellular distribution of AGT among mammals. ..
- Holbrook J, Danpure C. Molecular basis for the dual mitochondrial and cytosolic localization of alanine:glyoxylate aminotransferase in amphibian liver cells. J Biol Chem. 2002;277:2336-44 pubmed..These results are discussed not only in terms of the molecular evolution of AGT targeting but also in terms of the ancillary requirements for the peroxisomal targeting of human AGT. ..
- Harper N, Hughes M, Farrow S, Cohen G, MacFarlane M. Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling. J Biol Chem. 2003;278:44338-47 pubmed
- Valentijn A, Gilmore A. Translocation of full-length Bid to mitochondria during anoikis. J Biol Chem. 2004;279:32848-57 pubmed..Our data indicate that Bid is important for regulating apoptosis via the intrinsic pathway and has implications for how Bid may fulfill that role. ..
- McQuibban G, Lee J, Zheng L, Juusola M, Freeman M. Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. Curr Biol. 2006;16:982-9 pubmed..rhomboid-7 mutant flies also have a greatly reduced lifespan. ..
- Sweetlove L, Lytovchenko A, Morgan M, Nunes Nesi A, Taylor N, Baxter C, et al. Mitochondrial uncoupling protein is required for efficient photosynthesis. Proc Natl Acad Sci U S A. 2006;103:19587-92 pubmed..Collectively, these results suggest that the main physiological role of UCP1 in Arabidopsis leaves is related to maintaining the redox poise of the mitochondrial electron transport chain to facilitate photosynthetic metabolism. ..
- Wilkinson S, Taylor M, Horn D, Kelly J, Cheeseman I. A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proc Natl Acad Sci U S A. 2008;105:5022-7 pubmed publisher..This potential for drug resistance by a simple mechanism has important implications, because nifurtimox is currently undergoing phase III clinical trials against African trypanosomiasis. ..
- Cleeter M, Chau K, Gluck C, Mehta A, Hughes D, Duchen M, et al. Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage. Neurochem Int. 2013;62:1-7 pubmed publisher..We suggest that GBA mutations and reduced GCase activity may increase the risk for PD by inducing these same abnormalities in PD brain...
- Cao Z, Subramaniam S, Bulleid N. Lack of an efficient endoplasmic reticulum-localized recycling system protects peroxiredoxin IV from hyperoxidation. J Biol Chem. 2014;289:5490-8 pubmed publisher..Our results demonstrate that peroxiredoxin IV recycling in the endoplasmic reticulum is much less efficient than in the cytosol or mitochondria, leading to the protection of peroxiredoxin IV from hyperoxidation. ..
- Boyd P, Tu W, Shorrock H, Groen E, Carter R, Powis R, et al. Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy. PLoS Genet. 2017;13:e1006744 pubmed publisher..We conclude that global bioenergetics pathways can be therapeutically manipulated to ameliorate SMA motor neuron phenotypes in vivo. ..
- Lumb M, Danpure C. Functional synergism between the most common polymorphism in human alanine:glyoxylate aminotransferase and four of the most common disease-causing mutations. J Biol Chem. 2000;275:36415-22 pubmed..These results are discussed in the light of the high allelic frequency ( approximately 20%) of the P11L polymorphism and its importance in determining the phenotypic manifestations of mutations in PH1. ..
- Coates P, Nenutil R, McGregor A, Picksley S, Crouch D, Hall P, et al. Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. Exp Cell Res. 2001;265:262-73 pubmed..The data support conserved roles for the prohibitins in regulating mitochondrial respiratory activity and in aging. ..
- Casley C, Land J, Sharpe M, Clark J, Duchen M, Canevari L. Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons. Neurobiol Dis. 2002;10:258-67 pubmed..In astrocytes mitochondrial impairment was confined to complex I inhibition, whereas in neurons a generalized loss of mitochondria was seen. ..
- Escobar N, Haupt S, Thow G, Boevink P, Chapman S, Oparka K. High-throughput viral expression of cDNA-green fluorescent protein fusions reveals novel subcellular addresses and identifies unique proteins that interact with plasmodesmata. Plant Cell. 2003;15:1507-23 pubmed..This virus-based system represents a method for high-throughput functional genomic study of plant cell organelles and allows the identification of unique proteins that associate with specific subcompartments within organelles...