Genomes and Genes
Experts and Doctors on mitochondria in Germany
Publications317 found, 100 shown here
- Fahrein K, Talarico G, Braband A, Podsiadlowski L. The complete mitochondrial genome of Pseudocellus pearsei (Chelicerata: Ricinulei) and a comparison of mitochondrial gene rearrangements in Arachnida. BMC Genomics. 2007;8:386 pubmed publisher..Some gene order changes are valuable characters in phylogenetic analysis of intraordinal relationships, e.g. in Acari...
- Degrandi D, Hoffmann R, Beuter Gunia C, Pfeffer K. The proinflammatory cytokine-induced IRG1 protein associates with mitochondria. J Interferon Cytokine Res. 2009;29:55-67 pubmed publisher..Furthermore, this study identifies 35 genes that constitute the IFN-gamma/TNF-triggered effector program in innate immunity...
- Wisniewski J, Zougman A, Nagaraj N, Mann M. Universal sample preparation method for proteome analysis. Nat Methods. 2009;6:359-62 pubmed publisher..Peptides eluted after digestion on the filter were pure, allowing single-run analyses of organelles and an unprecedented depth of proteome coverage. ..
- Ristow M, Zarse K. How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). Exp Gerontol. 2010;45:410-8 pubmed publisher..Hence, the concept of mitohormesis provides a common mechanistic denominator for the physiological effects of physical exercise, reduced calorie uptake, glucose restriction, and possibly beyond. ..
- Baris O, Klose A, Kloepper J, Weiland D, Neuhaus J, Schauen M, et al. The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells. 2011;29:1459-68 pubmed publisher..In conclusion, we here provide unequivocal evidence that EPSCs, and probably tissue stem cells in general, are independent of the mitochondrial respiratory chain, but still require a functional dynamic mitochondrial compartment. ..
- Gupta K, Igamberdiev A, Manjunatha G, Segu S, Moran J, Neelawarne B, et al. The emerging roles of nitric oxide (NO) in plant mitochondria. Plant Sci. 2011;181:520-6 pubmed publisher..The contribution of NO turnover during pathogen defense, symbiosis and hypoxic stress is discussed in detail. ..
- Ponsuksili S, Murani E, Schwerin M, Schellander K, Tesfaye D, Wimmers K. Gene expression and DNA-methylation of bovine pretransfer endometrium depending on its receptivity after in vitro-produced embryo transfer. PLoS ONE. 2012;7:e42402 pubmed publisher..Key components of these molecular pathways are known to be dependent on ovarian hormones that promote uterine receptivity. ..
- Kastl L, Sauer S, Ruppert T, Beissbarth T, Becker M, Süss D, et al. TNF-α mediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-κB activation in liver cells. FEBS Lett. 2014;588:175-83 pubmed publisher..7-fold. This study identifies complex I and complex III of the mitochondrial respiratory chain as point of release of ROS upon TNF-α stimulation of liver cells, which enhances cell migration by activating NF-κB signalling. ..
- Casadei N, Sood P, Ulrich T, Fallier Becker P, Kieper N, Helling S, et al. Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2. Hum Mol Genet. 2016;25:459-71 pubmed publisher..The location and abundance of HtrA2 is tightly controlled and, therefore, human mutations leading to gain- or loss of function could provide significant risk for PD-related neurodegeneration. ..
- Cooper H, Yang Y, Ylikallio E, Khairullin R, Woldegebriel R, Lin K, et al. ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia. Hum Mol Genet. 2017;26:1432-1443 pubmed publisher..This finding extends the group of mitochondrial inner membrane AAA proteins associated with spasticity. ..
- Schricker R, Magdolen V, Kaniak A, Wolf K, Bandlow W. The adenylate kinase family in yeast: identification of URA6 as a multicopy suppressor of deficiency in major AMP kinase. Gene. 1992;122:111-8 pubmed
- Uhlig S, Wendel A. The physiological consequences of glutathione variations. Life Sci. 1992;51:1083-94 pubmed..Thus, in cases of severe GSH-depletion a substitution of GSH as a therapeutic measure seems justified. Such a severe depletion of GSH has been described for some diseases such as liver dysfunction, AIDS or pulmonary fibrosis. ..
- Meinhardt A, Parvinen M, Bacher M, Aumuller G, Hakovirta H, Yagi A, et al. Expression of mitochondrial heat shock protein 60 in distinct cell types and defined stages of rat seminiferous epithelium. Biol Reprod. 1995;52:798-807 pubmed..The presence of hsp60 in stages with mitotic activity suggests a very active mitochondrial protein import and protein assembly machinery that generates further mitochondria for the dividing cells. ..
- Schneider H, Westermann B, Neupert W, Brunner M. The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import. EMBO J. 1996;15:5796-803 pubmed..Subsequently, the release of mt-Hsp70 from the polypeptide chain is triggered by Mge1p which promotes release of ADP from mt-Hsp70. Rebinding of ATP to mt-Hsp70 completes the reaction cycle. ..
- Missel A, Souza A, N rskau G, G ringer H. Disruption of a gene encoding a novel mitochondrial DEAD-box protein in Trypanosoma brucei affects edited mRNAs. Mol Cell Biol. 1997;17:4895-903 pubmed..The results suggest an involvement of mHel61p in the control of the abundance of edited mRNAs and thus reveal a novel function for DEAD-box proteins...
- Rehling P, Wiedemann N, Pfanner N, Truscott K. The mitochondrial import machinery for preproteins. Crit Rev Biochem Mol Biol. 2001;36:291-336 pubmed..Moreover, we are now approaching a new era in which elaborated techniques have already allowed and will enable us to gather information about the TOM and TIM complexes on an ultrastructural level. ..
- Luetjens C, Kogel D, Reimertz C, Dussmann H, Renz A, Schulze Osthoff K, et al. Multiple kinetics of mitochondrial cytochrome c release in drug-induced apoptosis. Mol Pharmacol. 2001;60:1008-19 pubmed..Our data indicate the existence of multiple kinetics of cytochrome c release in drug-induced apoptosis. ..
- Rajalingam K, al Younes H, Muller A, Meyer T, Szczepek A, Rudel T. Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis. Infect Immun. 2001;69:7880-8 pubmed..Consequently, active caspase-3 was absent in infected cells. Our data suggest a direct modulation of apoptotic pathways in epithelial cells by C. pneumoniae. ..
- Schinzel A, Kaufmann T, Schuler M, Martinalbo J, Grubb D, Borner C. Conformational control of Bax localization and apoptotic activity by Pro168. J Cell Biol. 2004;164:1021-32 pubmed..Moreover, the mutants have their NH2 termini exposed. We propose that Pro168 links the NH2 and the COOH terminus of Bax and is required for COOH-terminal release and mitochondrial targeting once this link is broken. ..
- Brandner K, Rehling P, Truscott K. The carboxyl-terminal third of the dicarboxylate carrier is crucial for productive association with the inner membrane twin-pore translocase. J Biol Chem. 2005;280:6215-21 pubmed..We concluded that, in this case, a single structural repeat can drive inner membrane insertion, whereas all three related units contribute targeting information for outer membrane translocation. ..
- Meier S, Neupert W, Herrmann J. Conserved N-terminal negative charges in the Tim17 subunit of the TIM23 translocase play a critical role in the import of preproteins into mitochondria. J Biol Chem. 2005;280:7777-85 pubmed..On the basis of these observations we propose that charged residues in Tim17 are critical for the preprotein-induced gating of the TIM23 translocase. ..
- Gerhard R, Burger S, Tatge H, Genth H, Just I, Hofmann F. Comparison of wild type with recombinant Clostridium difficile toxin A. Microb Pathog. 2005;38:77-83 pubmed..In summary, we tested the recombinant toxin A to be at least an adequate substitute for the native toxin, bearing the advantage of a rapid single-step purification and the absence of biological active contaminations...
- Bau V, Zierz S. Update on chronic progressive external ophthalmoplegia. Strabismus. 2005;13:133-42 pubmed..The efficacy of pharmacological therapies (e.g., coenzyme Q) has not been established so far. Symptomatic ophthalmological treatment includes ptosis and strabismus surgery. Early cardiac pacemaker implantation may be life-saving...
- Arab A, Kuemmerer K, Wang J, Bode C, Hehrlein C. Oxygenated perfluorochemicals improve cell survival during reoxygenation by pacifying mitochondrial activity. J Pharmacol Exp Ther. 2008;325:417-24 pubmed publisher..These effects of oxPFCs are dose-dependent, and they lead to a stabilization of the mitochondrial membrane potential, decreased steady-state levels of superoxide, and pacification of mitochondrial activity. ..
- Zick M, Rabl R, Reichert A. Cristae formation-linking ultrastructure and function of mitochondria. Biochim Biophys Acta. 2009;1793:5-19 pubmed publisher..Further, we formulate several theoretical models which could account for the de novo formation of cristae as well as their propagation from existing cristae. ..
- Schulz K, Eckert A, Rhein V, Mai S, Haase W, Reichert A, et al. A new link to mitochondrial impairment in tauopathies. Mol Neurobiol. 2012;46:205-16 pubmed publisher..Our findings clearly link tau bidirectional to mitochondrial function and dynamics, identifying a novel aspect of the physiological role of tau and the pathomechanism of tauopathies...
- Kondadi A, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, et al. Loss of the m-AAA protease subunit AFG?L? causes mitochondrial transport defects and tau hyperphosphorylation. EMBO J. 2014;33:1011-26 pubmed publisher..We propose that reactive oxygen species signaling leads to cytoskeletal modifications that impair mitochondrial transport in neurons lacking AFG?L?. ..
- Geissler A, Krimmer T, Schönfisch B, Meijer M, Rassow J. Biogenesis of the yeast frataxin homolog Yfh1p. Tim44-dependent transfer to mtHsp70 facilitates folding of newly imported proteins in mitochondria. Eur J Biochem. 2000;267:3167-80 pubmed..We conclude that Tim44 not only plays a role in protein translocation but also in the pathways of mitochondrial protein folding. ..
- Fritz S, Rapaport D, Klanner E, Neupert W, Westermann B. Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion. J Cell Biol. 2001;152:683-92 pubmed..A fusion machinery that is in contact with both mitochondrial membranes appears to be functionally important for coordinated fusion of four mitochondrial membranes. ..
- Mokranjac D, Sichting M, Popov Celeketic D, Berg A, Hell K, Neupert W. The import motor of the yeast mitochondrial TIM23 preprotein translocase contains two different J proteins, Tim14 and Mdj2. J Biol Chem. 2005;280:31608-14 pubmed..However, overexpressed Mdj2 fully restores the growth of cells lacking Tim14. We conclude that Mdj2 is a functional J protein and a component of the mitochondrial import motor. ..
- Artal Sanz M, Tavernarakis N. Opposing function of mitochondrial prohibitin in aging. Aging (Albany NY). 2010;2:1004-11 pubmed..The tight evolutionary conservation and ubiquitous expression of prohibitin proteins suggest a similar role for the mitochondrial prohibitin complex during aging in other organisms. ..
- Wischmann C, Schuster W. Transfer of rps10 from the mitochondrion to the nucleus in Arabidopsis thaliana: evidence for RNA-mediated transfer and exon shuffling at the integration site. FEBS Lett. 1995;374:152-6 pubmed..In vitro-translated RPS10 protein is efficiently imported into potato mitochondria and a presequence of about 7 kDa is removed resulting in a mature protein that is larger compared to organellar and bacterial RPS10 proteins. ..
- Westermann B, Neupert W. Mitochondria-targeted green fluorescent proteins: convenient tools for the study of organelle biogenesis in Saccharomyces cerevisiae. Yeast. 2000;16:1421-7 pubmed
- Geissler A, Rassow J, Pfanner N, Voos W. Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins. Mol Cell Biol. 2001;21:7097-104 pubmed
- Bureik M, Schiffler B, Hiraoka Y, Vogel F, Bernhardt R. Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1. Biochemistry. 2002;41:2311-21 pubmed..Therefore, we suggest to name this protein etp1 (electron-transfer protein 1). ..
- Dirsch V, Kirschke S, Estermeier M, Steffan B, Vollmar A. Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria. Oncogene. 2004;23:1586-93 pubmed..The activation of JNK contributes to this signaling upstream of mitochondria. ..
- Englert H, Heitsch H, Gerlach U, Knieps S. Blockers of the ATP-sensitive potassium channel SUR2A/Kir6.2: a new approach to prevent sudden cardiac death. Curr Med Chem Cardiovasc Hematol Agents. 2003;1:253-71 pubmed..As a highlight, first strategies to come to selective SUR2A/Kir6.2 blockers, such as HMR 1883, are reviewed...
- Scheckhuber C, Erjavec N, Tinazli A, Hamann A, Nystrom T, Osiewacz H. Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat Cell Biol. 2007;9:99-105 pubmed..Our data further suggest that reduced mitochondrial fission extends life span by increasing cellular resistance to the induction of apoptosis and links mitochondrial dynamics, apoptosis and life-span control. ..
- Klingenberg M. Wanderings in bioenergetics and biomembranes. Biochim Biophys Acta. 2010;1797:579-94 pubmed publisher..These wanderings are recalled with varying emphasis paid to the covered science stations. ..
- Rai A, Nöthe H, Tzvetkov N, Korenbaum E, Manstein D. Dictyostelium dynamin B modulates cytoskeletal structures and membranous organelles. Cell Mol Life Sci. 2011;68:2751-67 pubmed publisher..Other functions displayed by dynamin B are commonly associated with either classical dynamins or dynamin-related proteins. ..
- Osman C, Voelker D, Langer T. Making heads or tails of phospholipids in mitochondria. J Cell Biol. 2011;192:7-16 pubmed publisher..The discovery of proteins that regulate mitochondrial membrane lipid composition and of a multiprotein complex tethering ER to mitochondrial membranes has unveiled novel mechanisms of mitochondrial membrane biogenesis. ..
- Araujo W, Nunes Nesi A, Osorio S, Usadel B, Fuentes D, Nagy R, et al. Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture. Plant Cell. 2011;23:600-27 pubmed publisher..The data obtained are discussed in the context of the role of TCA cycle intermediates both generally with respect to photosynthetic metabolism and specifically with respect to their role in the regulation of stomatal aperture. ..
- Gross D, Burgard C, Reddehase S, Leitch J, Culotta V, Hell K. Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system. Mol Biol Cell. 2011;22:3758-67 pubmed publisher..Thus the disulfide relay system is able to form, in addition to double disulfide bonds in twin Cx(n)C motifs, single structural disulfide bonds in complex protein domains. ..
- Vernunft A, Alm H, Tuchscherer A, Kanitz W, Hinrichs K, Torner H. Chromatin and cytoplasmic characteristics of equine oocytes recovered by transvaginal ultrasound-guided follicle aspiration are influenced by the developmental stage of their follicle of origin. Theriogenology. 2013;80:1-9 pubmed publisher..These findings will help in effective scheduling of oocyte recovery for equine-assisted reproduction techniques. ..
- Schwarzkopf T, Koch K, Klein J. Neurodegeneration after transient brain ischemia in aged mice: beneficial effects of bilobalide. Brain Res. 2013;1529:178-87 pubmed publisher..In conclusion, aged mice show some differences in their response to transient ischemia when compared with young mice. Bilobalide has prominent neuroprotective properties in mice of all ages. ..
- Levchenko M, Wuttke J, Römpler K, Schmidt B, Neifer K, Juris L, et al. Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase. Biochim Biophys Acta. 2016;1863:1624-32 pubmed publisher..Our analyses reveal Cox26 as a novel stoichiometric structural subunit of the cytochrome c oxidase. A loss of Cox26 affects cytochrome c oxidase activity and respirasome organization. ..
- Chowdhury S, Reimer A, Sharan M, Kozjak Pavlovic V, Eulalio A, Prusty B, et al. Chlamydia preserves the mitochondrial network necessary for replication via microRNA-dependent inhibition of fission. J Cell Biol. 2017;216:1071-1089 pubmed publisher..We show that C. trachomatis require mitochondrial ATP for normal development and hence postulate that they preserve mitochondrial integrity through a miR-30c-5p-dependent inhibition of Drp1-mediated mitochondrial fission. ..
- Ehmke N, Graul Neumann L, Smorag L, Koenig R, Segebrecht L, Magoulas P, et al. De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction. Am J Hum Genet. 2017;101:833-843 pubmed publisher..Our results suggest that the SLC25A24 mutations induce a gain of pathological function and link mitochondrial ATP-Mg/Pi transport to the development of skeletal and connective tissue. ..
- Kispal G, Csere P, Guiard B, Lill R. The ABC transporter Atm1p is required for mitochondrial iron homeostasis. FEBS Lett. 1997;418:346-50 pubmed..The increased mitochondrial iron content may be causative of the oxidative damage of heme-containing proteins in delta atm1 cells. Our data assign an important function to Atm1p in mitochondrial iron homeostasis...
- van Dyck L, Neupert W, Langer T. The ATP-dependent PIM1 protease is required for the expression of intron-containing genes in mitochondria. Genes Dev. 1998;12:1515-24 pubmed..Transcripts of COXI and COB genes harboring multiple introns are degraded in the absence of PIM1. These results establish multiple, essential functions of the ATP-dependent PIM1 protease during mitochondrial gene expression. ..
- Loffler M, Klein A, Hayek Ouassini M, Knecht W, Konrad L. Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells. Nucleosides Nucleotides Nucleic Acids. 2004;23:1281-5 pubmed..In mouse B-lymphocytes, which were adapted to tolerate up to a 50-fold concentration of the DHODH inhibitor leflunomide, a 20 fold protein overexpression was measured. Southern blotting indicated DHODH gene amplification. ..
- Altmann K, Westermann B. Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. Mol Biol Cell. 2005;16:5410-7 pubmed..We conclude that these cellular pathways play an important role in mitochondrial morphogenesis and inheritance. ..
- Murin R, Verleysdonk S, Rapp M, Hamprecht B. Immunocytochemical localization of 3-methylcrotonyl-CoA carboxylase in cultured ependymal, microglial and oligodendroglial cells. J Neurochem. 2006;97:1393-402 pubmed..The ubiquitous expression of MCC in glial cells demonstrates the ability of the cells to engage in the catabolism of leucine transported into the brain, mainly for the generation of energy. ..
- Ewald R, Kolukisaoglu U, Bauwe U, Mikkat S, Bauwe H. Mitochondrial protein lipoylation does not exclusively depend on the mtKAS pathway of de novo fatty acid synthesis in Arabidopsis. Plant Physiol. 2007;145:41-8 pubmed..These data suggest that mitochondrial protein lipoylation does not exclusively depend on the mtKAS pathway of lipoate biosynthesis in leaves and may occur independently of this pathway in roots. ..
- Zhang M, Yu X, Xu Y, Jouhten P, Swapna G, Glaser R, et al. 13 C metabolic flux profiling of Pichia pastoris grown in aerobic batch cultures on glucose revealed high relative anabolic use of TCA cycle and limited incorporation of provided precursors of branched-chain amino acids. FEBS J. 2017;284:3100-3113 pubmed publisher..4.1.1), pyruvate kinase (EC 22.214.171.124), l-serine hydroxymethyltransferase (EC 126.96.36.199), threonine aldolase (EC 188.8.131.52), threonine dehydratase (EC 184.108.40.206); transketolase (EC 220.127.116.11), transaldolase (EC 18.104.22.168). ..
- Haslinger B, Strangfeld K, Peters G, Schulze Osthoff K, Sinha B. Staphylococcus aureus alpha-toxin induces apoptosis in peripheral blood mononuclear cells: role of endogenous tumour necrosis factor-alpha and the mitochondrial death pathway. Cell Microbiol. 2003;5:729-41 pubmed..aureus infection. ..
- Quintana A, Hoth M. Apparent cytosolic calcium gradients in T-lymphocytes due to fura-2 accumulation in mitochondria. Cell Calcium. 2004;36:99-109 pubmed..These methods are therefore suitable to study localized Ca2+ signals in large populations of T-cells while preserving their cytosolic integrity. ..
- Schiffler B, Bureik M, Reinle W, Müller E, Hannemann F, Bernhardt R. The adrenodoxin-like ferredoxin of Schizosaccharomyces pombe mitochondria. J Inorg Biochem. 2004;98:1229-37 pubmed..The kinetics of substrate conversion in the etp1(fd)-supported CYP11A1 and CYP11B1-dependent systems mediated was studied. ..
- Siemen D, Ziemer M. What is the nature of the mitochondrial permeability transition pore and what is it not?. IUBMB Life. 2013;65:255-62 pubmed publisher..Thereafter, this review will critically report about some of the unknown elements and hypotheses that had to be rejected. ..
- Fritz S, Weinbach N, Westermann B. Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. Mol Biol Cell. 2003;14:2303-13 pubmed..Our results suggest that Mdm30 controls mitochondrial shape by regulating the steady-state level of Fzo1 and point to a connection of the ubiquitin/26S proteasome system and mitochondria. ..
- Kölker S, Schwab M, Hörster F, Sauer S, Hinz A, Wolf N, et al. Methylmalonic acid, a biochemical hallmark of methylmalonic acidurias but no inhibitor of mitochondrial respiratory chain. J Biol Chem. 2003;278:47388-93 pubmed..Inhibition of respiratory chain and tricarboxylic acid cycle is most likely induced by synergistically acting alternative metabolites, in particular 2-methylcitric acid, malonic acid, and propionyl-CoA. ..
- Tillich M, Lehwark P, Morton B, Maier U. The evolution of chloroplast RNA editing. Mol Biol Evol. 2006;23:1912-21 pubmed..This is the first comprehensive model for the evolution of the chloroplast RNA-editing system of land plants and may also be applicable to the evolution of RNA editing in plant mitochondria...
- Wagener N, Ackermann M, Funes S, Neupert W. A pathway of protein translocation in mitochondria mediated by the AAA-ATPase Bcs1. Mol Cell. 2011;44:191-202 pubmed publisher..In bacteria and chloroplasts Rip1 uses the Tat machinery for topogenesis; however, mitochondria have lost this machinery during evolution and a member of the AAA-ATPase family has taken over its function. ..
- Zanon A, Kalvakuri S, Rakovic A, Foco L, Guida M, Schwienbacher C, et al. SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Hum Mol Genet. 2017;26:2412-2425 pubmed publisher..This finding places further emphasis on the significance of Parkin for the maintenance of mitochondrial function in neurons and provides a novel target for therapeutic strategies...
- Vukotic M, Nolte H, König T, Saita S, Ananjew M, Kruger M, et al. Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. Mol Cell. 2017;67:471-483.e7 pubmed publisher..The dual function of AGK as lipid kinase and constituent of the TIM22 complex reveals that disturbances in both phospholipid metabolism and mitochondrial protein biogenesis contribute to the pathogenesis of Sengers syndrome. ..
- Dimmer K, Jakobs S, Vogel F, Altmann K, Westermann B. Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast. J Cell Biol. 2005;168:103-15 pubmed..We propose that Mdm31 and Mdm32 cooperate with Mmm1, Mmm2, Mdm10, and Mdm12 in maintenance of mitochondrial morphology and mtDNA. ..
- Reumann S, Weber A. Plant peroxisomes respire in the light: some gaps of the photorespiratory C2 cycle have become filled--others remain. Biochim Biophys Acta. 2006;1763:1496-510 pubmed..This review highlights recent developments in understanding photorespiration and identifies remaining gaps in our knowledge of this important metabolic pathway. ..
- Kunze B, Steinmetz H, Hofle G, Huss M, Wieczorek H, Reichenbach H. Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (myxobacteria) with inhibitory effect on mitochondrial ATPase activity. Fermentation and biological properties. J Antibiot (Tokyo). 2006;59:664-8 pubmed..Cruentaren A inhibited F0F1 mitochondrial ATP-hydrolysis in submitochondrial particles of yeasts and beef heart. ..
- Mokranjac D, Berg A, Adam A, Neupert W, Hell K. Association of the Tim14.Tim16 subcomplex with the TIM23 translocase is crucial for function of the mitochondrial protein import motor. J Biol Chem. 2007;282:18037-45 pubmed..Deletion of hydrophobic segments in both, Tim16 and Tim14, is lethal. We conclude that import into the matrix space of mitochondria requires association of the co-chaperones Tim16 and Tim14 with the TIM23 preprotein translocase. ..
- Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, et al. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016;213:456-64 pubmed publisher..These defects impair antigen recognition and T cell function and are correlated with sepsis severity. Pharmacological targeting of these defects may improve T cell function and reduce the risk of sepsis. ..
- Wolff G, Burger G, Lang B, Kuck U. Mitochondrial genes in the colourless alga Prototheca wickerhamii resemble plant genes in their exons but fungal genes in their introns. Nucleic Acids Res. 1993;21:719-26 pubmed..Our finding of highly similar introns in fungi and algae is consistent with the idea that introns have already been present in the bacterial ancestors of present day mitochondria and evolved concomitantly with the organelles. ..
- Bauer N, Richter Landsberg C. The dynamic instability of microtubules is required for aggresome formation in oligodendroglial cells after proteolytic stress. J Mol Neurosci. 2006;29:153-68 pubmed..Furthermore, the binding of stress-induced alphaBcrystallin to the MTs points to a possible protective role during disease progression. ..
- Jonietz C, Forner J, Hölzle A, Thuss S, Binder S. RNA PROCESSING FACTOR2 is required for 5' end processing of nad9 and cox3 mRNAs in mitochondria of Arabidopsis thaliana. Plant Cell. 2010;22:443-53 pubmed publisher..The identification of RPF2 is a major step toward the characterization of 5' mRNA processing in mitochondria of higher plants. ..
- Zeth K, Thein M. Porins in prokaryotes and eukaryotes: common themes and variations. Biochem J. 2010;431:13-22 pubmed publisher..Despite the lack of a clear evolutionary link between these protein families, their common principles and differences in assembly, architecture and function are summarized in the present review. ..
- Rapaport D, Brunner M, Neupert W, Westermann B. Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem. 1998;273:20150-5 pubmed..It is imported into the outer membrane in a receptor-dependent manner. Fzo1p is part of a larger protein complex of 800 kDa, and presumably is the first identified component of the yeast mitochondrial fusion machinery. ..
- Pfeiffer I, Burger J, Brenig B. Diagnostic polymorphisms in the mitochondrial cytochrome b gene allow discrimination between cattle, sheep, goat, roe buck and deer by PCR-RFLP. BMC Genet. 2004;5:30 pubmed..e., species) of blood traces obtained from a leaf. The method presented can be used for the discrimination of cattle (Bos taurus), sheep (Ovis aries), goat (Capra hircus), roe buck (Capreolus capreolus) and red deer (Cervus elaphus). ..
- Kashkar H, Wiegmann K, Yazdanpanah B, Haubert D, Kronke M. Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane. J Biol Chem. 2005;280:20804-13 pubmed..The results suggest that UV light-triggered ASMase activation is essentially required for Bax conformational change leading to mitochondrial release of pro-apoptotic factors like cytochrome c and Smac. ..
- Habarou F, Hamel Y, Haack T, Feichtinger R, Lebigot E, Marquardt I, et al. Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy. Am J Hum Genet. 2017;101:283-290 pubmed publisher..Lipoic acid supplementation did not improve clinical condition nor activities of PDHc, ?-KGDHc, or leucine metabolism in fibroblasts and was ineffective in yeast deleted for the orthologous LIP2. ..
- Klein Geltink R, O Sullivan D, Corrado M, Bremser A, Buck M, Buescher J, et al. Mitochondrial Priming by CD28. Cell. 2017;171:385-397.e11 pubmed publisher..Our data show that initial CD28 signals during T cell activation prime mitochondria with latent metabolic capacity that is essential for future T cell responses. ..
- Newton C, Bilko D, Tichomirowa M, Renner U, Stalla G. The role of poly (adenosine 5'-diphosphate-ribose) polymerase in the response of pituitary tumor cells to reactive oxygen species. Endocrinology. 2005;146:1119-27 pubmed
- Sichting M, Mokranjac D, Azem A, Neupert W, Hell K. Maintenance of structure and function of mitochondrial Hsp70 chaperones requires the chaperone Hep1. EMBO J. 2005;24:1046-56 pubmed..This process is efficiently counteracted by Hep1. We conclude that Hep1 acts as a chaperone that is necessary and sufficient to prevent self-aggregation and to thereby maintain the function of the mitochondrial Hsp70 chaperones. ..
- Standl E. Dysglycemia and abdominal obesity. Curr Vasc Pharmacol. 2012;10:678-9 pubmed..In addition, the multiple effects of insulin also on the regulation of the vasculature are shifted towards vasoconstriction and proliferation in the context of insulin resistance and the excessively high levels. ..