Genomes and Genes
Experts and Doctors on mitochondria in France
Publications435 found, 100 shown here
- Clémençon B, Rey M, Dianoux A, Trezeguet V, Lauquin G, Brandolin G, et al. Structure-function relationships of the C-terminal end of the Saccharomyces cerevisiae ADP/ATP carrier isoform 2. J Biol Chem. 2008;283:11218-25 pubmed publisher..Taken together, our results highlight the involvement of the Anc2p C-terminal region in nucleotide recognition, binding, and transport. ..
- Susin S, Lorenzo H, Zamzami N, Marzo I, Brenner C, Larochette N, et al. Mitochondrial release of caspase-2 and -9 during the apoptotic process. J Exp Med. 1999;189:381-94 pubmed
- Teulier L, Rouanet J, Letexier D, Romestaing C, Belouze M, Rey B, et al. Cold-acclimation-induced non-shivering thermogenesis in birds is associated with upregulation of avian UCP but not with innate uncoupling or altered ATP efficiency. J Exp Biol. 2010;213:2476-82 pubmed publisher..In the absence of mitochondrial uncoupling, these data indicate a clear link between avUCP expression and the capacity of ducklings to adjust their muscular aerobic activity to cold exposure. ..
- Procaccio V, Depetris D, Soularue P, Mattei M, Lunardi J, Issartel J. cDNA sequence and chromosomal localization of the NDUFS8 human gene coding for the 23 kDa subunit of the mitochondrial complex I. Biochim Biophys Acta. 1997;1351:37-41 pubmed..Two clusters of four cysteine residues are conserved among these proteins. The gene (NDUFS8) coding for the human subunit has been mapped to chromosome 11q13. ..
- Djouadi F, Brandt J, Weinheimer C, Leone T, Gonzalez F, Kelly D. The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism. Prostaglandins Leukot Essent Fatty Acids. 1999;60:339-43 pubmed..These results identify an important role for PPARalpha in the control of cardiac lipid metabolism. ..
- Vidau C, Gonzalez Polo R, Niso Santano M, Gómez Sánchez R, Bravo San Pedro J, Pizarro Estrella E, et al. Fipronil is a powerful uncoupler of oxidative phosphorylation that triggers apoptosis in human neuronal cell line SHSY5Y. Neurotoxicology. 2011;32:935-43 pubmed publisher..Thus in this study, we report a new mode of action by which the insecticide fipronil could triggers apoptosis. ..
- Guerin J, Cornut Thibaut A, Giscard Destaing S, Pouvreau S, Guillemin Y, Aouacheria A. Subcellular dynamics of the maternal cell death regulator BCL2L10 in human preimplantation embryos. Hum Reprod. 2013;28:729-39 pubmed publisher..What is the expression status and subcellular localization of the maternally expressed Bcl-2 family member, BCL2L10, in early human embryos of diverse developmental stages and quality?..
- Trian T, Benard G, Begueret H, Rossignol R, Girodet P, Ghosh D, et al. Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma. J Exp Med. 2007;204:3173-81 pubmed..Thus, BSM in asthmatic patients is characterized by an altered calcium homeostasis that increases mitochondrial biogenesis, which, in turn, enhances cell proliferation, leading to airway remodeling. ..
- Bonaïti B, Olsson M, Hellman U, Suhr O, Bonaïti Pellié C, Plante Bordeneuve V. TTR familial amyloid polyneuropathy: does a mitochondrial polymorphism entirely explain the parent-of-origin difference in penetrance?. Eur J Hum Genet. 2010;18:948-52 pubmed publisher..In clinical practice, these results might help to better delineate the individual disease risk and have a significant impact on the management of both patients and carriers. ..
- Mauduit C, Goddard I, Besset V, Tabone E, Rey C, Gasnier F, et al. Leukemia inhibitory factor antagonizes gonadotropin induced-testosterone synthesis in cultured porcine leydig cells: sites of action. Endocrinology. 2001;142:2509-20 pubmed
- Alphonse G, Bionda C, Aloy M, Ardail D, Rousson R, Rodriguez Lafrasse C. Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels. Oncogene. 2004;23:2703-15 pubmed..Modulation of endogenous ceramide levels by inhibitors of sphingolipid metabolism may represent a new cellular target for the sensitization of radioresistant tumours to gamma-ray therapy. ..
- Malka F, Guillery O, Cifuentes Diaz C, Guillou E, Belenguer P, Lombes A, et al. Separate fusion of outer and inner mitochondrial membranes. EMBO Rep. 2005;6:853-9 pubmed..The separate fusion of outer and inner membranes and the different requirements of these fusion reactions point to the existence of fusion machineries that can function separately. ..
- Araiso Y, Huot J, Sekiguchi T, Frechin M, Fischer F, Enkler L, et al. Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases. Nucleic Acids Res. 2014;42:6052-63 pubmed publisher..The positive surface charge and novel fold of the GatF-GatA interface, shown in this first crystal structure of an organellar AdT, stand in contrast with the more conventional, negatively charged bacterial AdTs described previously. ..
- Haouzi D, Cohen I, Vieira H, Poncet D, Boya P, Castedo M, et al. Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivo. Apoptosis. 2002;7:395-405 pubmed..Acetaminophen (paracetamol)-induced acute poisoning was also attenuated by CsA and GSH, both in vitro and in vivo. Altogether these data indicate that PTPC-mediated MMP may determine the hepatorenal toxicity of xenobiotics in vivo. ..
- Weber Lotfi F, Dietrich A, Russo M, Rubino L. Mitochondrial targeting and membrane anchoring of a viral replicase in plant and yeast cells. J Virol. 2002;76:10485-96 pubmed
- Boya P, Andreau K, Poncet D, Zamzami N, Perfettini J, Metivier D, et al. Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med. 2003;197:1323-34 pubmed..Altogether, our data indicate that mitochondria are indispensable for cell death initiated by lysosomal destabilization. ..
- Kerdelhué C, Zane L, Simonato M, Salvato P, Rousselet J, Roques A, et al. Quaternary history and contemporary patterns in a currently expanding species. BMC Evol Biol. 2009;9:220 pubmed publisher..In contrast, in regions that experienced the most intense Quaternary climatic oscillations, the natural populations are not genetically structured, and contemporary patterns of population expansion remain undetected. ..
- Aguer C, Mercier J, Man C, Metz L, Bordenave S, Lambert K, et al. Intramyocellular lipid accumulation is associated with permanent relocation ex vivo and in vitro of fatty acid translocase (FAT)/CD36 in obese patients. Diabetologia. 2010;53:1151-63 pubmed publisher..In cultured myotubes, IMCL content and FAT/CD36 relocation are independent of type 2 diabetes, suggesting that distinct factors in obesity and type 2 diabetes contribute to permanent FAT/CD36 relocation ex vivo. ..
- Habersetzer J, Ziani W, Larrieu I, Stines Chaumeil C, Giraud M, Brèthes D, et al. ATP synthase oligomerization: from the enzyme models to the mitochondrial morphology. Int J Biochem Cell Biol. 2013;45:99-105 pubmed publisher..This review also discusses the physiological role of this oligomerization process and its potential implications in mammal pathology. This article is part of a Directed Issue entitled: Bioenergetic Dysfunction, adaptation and therapy. ..
- Boya P, Roques B, Kroemer G. New EMBO members' review: viral and bacterial proteins regulating apoptosis at the mitochondrial level. EMBO J. 2001;20:4325-31 pubmed..It may be speculated that such proteins employ pre-existing host-intrinsic mechanisms of MMP control. ..
- Savagner F, Franc B, Guyetant S, Rodien P, Reynier P, Malthiery Y. Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors. J Clin Endocrinol Metab. 2001;86:4920-5 pubmed..Adenosine triphosphate synthesis was significantly lower in all the tumors, compared with controls, suggesting that a coupling defect in oxidative phosphorylation may be a cause of mitochondrial hyperplasia in oxyphilic thyroid tumors...
- Roy V, Demanche C, Livet A, Harry M. Genetic differentiation in the soil-feeding termite Cubitermes sp. affinis subarquatus: occurrence of cryptic species revealed by nuclear and mitochondrial markers. BMC Evol Biol. 2006;6:102 pubmed
- Caron M, Auclair M, Donadille B, Bereziat V, Guerci B, Laville M, et al. Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence. Cell Death Differ. 2007;14:1759-67 pubmed..These alterations could participate in the pathophysiology of lipodystrophic syndromes and lead to premature ageing complications. ..
- Farina F, Alberti A, Breuil N, Bolotin Fukuhara M, Pinto M, Culetto E. Differential expression pattern of the four mitochondrial adenine nucleotide transporter ant genes and their roles during the development of Caenorhabditis elegans. Dev Dyn. 2008;237:1668-81 pubmed publisher..1 is also required postembryonically because RNAi mutants exhibit small size and life-span extension. Our results suggest that ant-1.1 is the only ant gene strictly required for embryonic and postembryonic development in C. elegans. ..
- Al Kaddissi S, Legeay A, Elia A, Gonzalez P, Camilleri V, Gilbin R, et al. Effects of uranium on crayfish Procambarus clarkii mitochondria and antioxidants responses after chronic exposure: what have we learned?. Ecotoxicol Environ Saf. 2012;78:218-24 pubmed publisher..However a multiple biomarker approach is recommended as the perturbed pathways and the mode of action of this pollutant are not completely understood. ..
- Alphonse G, Maalouf M, Battiston Montagne P, Ardail D, Beuve M, Rousson R, et al. p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation. BMC Cancer. 2013;13:151 pubmed publisher..We propose that ceramide is the molecular bridge between mitotic catastrophe and the commitment phase of delayed apoptosis in response to irradiation. ..
- Koll F, Sidoti C, Rincheval V, Lecellier G. Mitochondrial membrane potential and ageing in Podospora anserina. Mech Ageing Dev. 2001;122:205-17 pubmed..We also show that the driving force of Psi(mt) is principally maintained by the alternative pathway during ageing, suggesting a role of the alternative oxidase pathway. ..
- Vieira H, Kroemer G. Mitochondria as targets of apoptosis regulation by nitric oxide. IUBMB Life. 2003;55:613-6 pubmed..This effect may involve a direct effect on the PTPC and/or indirect effects secondary to the NO-mediated inhibition of oxidative phosphorylation. This has far-reaching implications for the pathophysiology of NO. ..
- Manon S, Guerin M. The ATP-induced K(+)-transport pathway of yeast mitochondria may function as an uncoupling pathway. Biochim Biophys Acta. 1997;1318:317-21 pubmed..AT 5 mM phosphate, no uncoupling effect of K+ could be evidenced. These data suggest that the ATP-induced K(+)-transport pathway may, under certain conditions, function as an uncoupling pathway of oxidative phosphorylation. ..
- Poupon V, Begue B, Gagnon J, Dautry Varsat A, Cerf Bensussan N, Benmerah A. Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase. J Biol Chem. 1999;274:19188-94 pubmed..These results indicate that p48, called MT-ACT48 (mitochondrial acyl-CoA thioesterase of 48 kDa), defines a novel family of mitochondrial long chain acyl-CoA thioesterases. ..
- Nebigil C, Jaffré F, Messaddeq N, Hickel P, Monassier L, Launay J, et al. Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy. Circulation. 2003;107:3223-9 pubmed..This observation suggests a role for mitochondria in the hypertrophic signaling that is regulated by serotonin. These transgenic mice provide a new genetic model for hypertrophic heart disease. ..
- Barrey E, Saint Auret G, Bonnamy B, Damas D, Boyer O, Gidrol X. Pre-microRNA and mature microRNA in human mitochondria. PLoS ONE. 2011;6:e20220 pubmed publisher..The origin of these pre-miRNA and miRNA should be further investigate to determine if they are imported from the cytosol and/or if they are partially processed in the mitochondria. ..
- Sosso D, Mbelo S, Vernoud V, Gendrot G, Dedieu A, Chambrier P, et al. PPR2263, a DYW-Subgroup Pentatricopeptide repeat protein, is required for mitochondrial nad5 and cob transcript editing, mitochondrion biogenesis, and maize growth. Plant Cell. 2012;24:676-91 pubmed publisher..The results suggest that mitochondrial RNA editing at the cob-908 site is necessary for mitochondrion biogenesis, cell division, and plant growth in maize. ..
- Eschbach J, Sinniger J, Bouitbir J, Fergani A, Schlagowski A, Zoll J, et al. Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age. Neurobiol Dis. 2013;58:220-30 pubmed publisher..Our results show that dynein function is required for the maintenance of mitochondrial morphology and function with aging and suggest that mitochondrial dysfunction contributes to dynein-dependent neurological diseases, such as SMA-LED. ..
- Leong K, Looi C, Loong X, Cheah F, Supratman U, Litaudon M, et al. Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line. PLoS ONE. 2016;11:e0152652 pubmed publisher..The results show that further development of the cycloartane as an anti-cancer drug is worthwhile. ..
- Camougrand N, Pelissier P, Velours G, Guerin M. NCA2, a second nuclear gene required for the control of mitochondrial synthesis of subunits 6 and 8 of ATP synthase in Saccharomyces cerevisiae. J Mol Biol. 1995;247:588-96 pubmed..2 kb mRNA but did not abolish the respiratory competence of a wild-type strain. Hybridization analyses indicated that NCA2 is located on chromosome XVI and produces a single 2750 base transcript. ..
- Emre Y, Hurtaud C, Nubel T, Criscuolo F, Ricquier D, Cassard Doulcier A. Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages. Biochem J. 2007;402:271-8 pubmed..Additionally, we found that the absence of UCP2 renders macrophages more resistant to nitric oxide-induced apoptosis. ..
- Carriere A, Ebrahimian T, Dehez S, Auge N, Joffre C, André M, et al. Preconditioning by mitochondrial reactive oxygen species improves the proangiogenic potential of adipose-derived cells-based therapy. Arterioscler Thromb Vasc Biol. 2009;29:1093-9 pubmed publisher..Our study demonstrates that in vitro preconditioning by moderate mitochondrial ROS generation strongly increases in vivo ADSC proangiogenic properties and emphasizes the crucial role of mitochondrial ROS in ADSC fate. ..
- Seguin A, Sutak R, Bulteau A, Garcia Serres R, Oddou J, Lefevre S, et al. Evidence that yeast frataxin is not an iron storage protein in vivo. Biochim Biophys Acta. 2010;1802:531-8 pubmed publisher..Our results do not privilege the hypothesis of Yfh1p being an iron storage protein in vivo. ..
- Jalmar O, García Sáez A, Berland L, Gonzalvez F, Petit P. Giant unilamellar vesicles (GUVs) as a new tool for analysis of caspase-8/Bid-FL complex binding to cardiolipin and its functional activity. Cell Death Dis. 2010;1:e103 pubmed publisher..This phenomenon was previously only poorly documented and substantially underestimated. ..
- Lefevre S, Sliwa D, Auchère F, Brossas C, Ruckenstuhl C, Boggetto N, et al. The yeast metacaspase is implicated in oxidative stress response in frataxin-deficient cells. FEBS Lett. 2012;586:143-8 pubmed publisher..In addition, our results suggest that metacaspase is associated with mitochondrial respiration, intracellular redox control and genomic stability. ..
- Razaka Jolly D, Rigoulet M, Guerin B, Velours J. Mutation in the hydrophobic domain of ATP synthase subunit 4 (subunit b) of yeast mitochondria disturbs coupling between proton translocation and catalysis. Biochemistry. 1994;33:9684-91 pubmed..From these results, we propose that the dicyclohexylcarbodiimide inhibition site is located upstream of the oligomycin inhibition site when considering the proton flux occurring during ATP synthesis. ..
- Audebert M, Charbonnier J, Boiteux S, Radicella J. Mitochondrial targeting of human 8-oxoguanine DNA glycosylase hOGG1 is impaired by a somatic mutation found in kidney cancer. DNA Repair (Amst). 2002;1:497-505 pubmed..These results imply that these cancer cells are deficient in their mitochondrial 8-oxoG DNA repair activity. ..
- Queval G, Hager J, Gakiere B, Noctor G. Why are literature data for H2O2 contents so variable? A discussion of potential difficulties in the quantitative assay of leaf extracts. J Exp Bot. 2008;59:135-46 pubmed publisher..Particular attention is drawn to the influence of tissue mass/extraction volume in the quantitative estimation of H2O2 contents, and the possibility that this factor could contribute to the variability of literature data. ..
- Rey B, Sibille B, Romestaing C, Belouze M, Letexier D, Servais S, et al. Reptilian uncoupling protein: functionality and expression in sub-zero temperatures. J Exp Biol. 2008;211:1456-62 pubmed publisher..All together, these data support a physiological role of the repUCP in superoxide limitation by lizard mitochondria in situations of stressful oxidative reperfusion following a re-warming period in winter. ..
- Mathieu L, Bourens M, Marsy S, Hlavacek O, Panozzo C, Dujardin G. A mutational analysis reveals new functional interactions between domains of the Oxa1 protein in Saccharomyces cerevisiae. Mol Microbiol. 2010;75:474-88 pubmed publisher..This analysis reveals the existence of functional interactions between TM2 and TM5, TM4 and TM5 as well as between TM4 and loop 2, highlighting the key position of TM4 and TM5 in the Oxa1 protein. ..
- Haïli N, Arnal N, Quadrado M, Amiar S, Tcherkez G, Dahan J, et al. The pentatricopeptide repeat MTSF1 protein stabilizes the nad4 mRNA in Arabidopsis mitochondria. Nucleic Acids Res. 2013;41:6650-63 pubmed publisher..Our study also reveals that short RNA molecules corresponding to pentatricopeptide repeat-binding sites accumulate also in plant mitochondria. ..
- Duroc Y, Gaillard C, Hiard S, Defrance M, Pelletier G, Budar F. Biochemical and functional characterization of ORF138, a mitochondrial protein responsible for Ogura cytoplasmic male sterility in Brassiceae. Biochimie. 2005;87:1089-100 pubmed..The production of this protein strongly inhibited bacterial growth, but not by inhibiting respiration. The observed toxic effects required both the hydrophilic and hydrophobic moieties of the protein. ..
- Morel C, Adami P, Musard J, Duval D, Radom J, Jouvenot M. Involvement of sulfhydryl oxidase QSOX1 in the protection of cells against oxidative stress-induced apoptosis. Exp Cell Res. 2007;313:3971-82 pubmed..The protective effect is partly due to a preservation of the mitochondrial polarization generally lost after an oxidative stress. These results strengthen our hypothesis of a protective role of QSOX1 against apoptosis. ..
- Pierrel F, Hamelin O, Douki T, Kieffer Jaquinod S, Muhlenhoff U, Ozeir M, et al. Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis. Chem Biol. 2010;17:449-59 pubmed publisher..Our study identifies pABA, Yah1p, and Arh1p as three actors in Q(6) biosynthesis. ..
- Maury J, Kerbey A, Priestman D, Patel M, Girard J, Ferre P. Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat. Biochem J. 1995;311 ( Pt 2):531-5 pubmed
- Magnon C, Galaup A, Mullan B, Rouffiac V, Bouquet C, Bidart J, et al. Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins. Cancer Res. 2005;65:4353-61 pubmed..Taken together, these results provide insights into how canstatin might exert its strong anticancer effect. ..
- Sieber F, Placido A, El Farouk Ameqrane S, Duchene A, Maréchal Drouard L. A protein shuttle system to target RNA into mitochondria. Nucleic Acids Res. 2011;39:e96 pubmed publisher..We anticipate our novel approach to be the starting point for various studies on mitochondrial processes. Finally, our study provides new insights into the mechanism of RNA import into mitochondria. ..
- Arselin G, Gandar J, Guerin B, Velours J. Isolation and complete amino acid sequence of the mitochondrial ATP synthase epsilon-subunit of the yeast Saccharomyces cerevisiae. J Biol Chem. 1991;266:723-7 pubmed..This polypeptide is rather basic since it contains 7 basic residues and 3 acidic residues. This study shows a slight similarity with the bovine epsilon-subunit ATP synthase since there are 16 identical residues. ..
- Susin S, Zamzami N, Castedo M, Daugas E, Wang H, Geley S, et al. The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med. 1997;186:25-37 pubmed..In addition, they provide a plausible explanation of why Bcl-2 fails to interfere with Fas-triggered apoptosis in most cell types, yet prevents ceramide- and prooxidant-induced apoptosis. ..
- Levillain O, Hus Citharel A, Garvi S, Peyrol S, Reymond I, Mutin M, et al. Ornithine metabolism in male and female rat kidney: mitochondrial expression of ornithine aminotransferase and arginase II. Am J Physiol Renal Physiol. 2004;286:F727-38 pubmed..The fate of L-ornithine may depend on the cellular context. ..
- Thomas D, Bron P, Weimann T, Dautant A, Giraud M, Paumard P, et al. Supramolecular organization of the yeast F1Fo-ATP synthase. Biol Cell. 2008;100:591-601 pubmed publisher..For a large range of organisms, it has been shown that mitochondrial ATP synthase adopts oligomeric structures. Moreover, several studies have suggested that a link exists between ATP synthase and mitochondrial morphology...
- Chami M, Oulès B, Szabadkai G, Tacine R, Rizzuto R, Paterlini Brechot P. Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress. Mol Cell. 2008;32:641-51 pubmed publisher..Thus, by bridging ER stress to apoptosis through increased ER-mitochondria Ca(2+) transfer, S1T acts as an essential determinant of cellular fate. ..
- Le Pennec S, Mirebeau Prunier D, Boutet Bouzamondo N, Jacques C, Guillotin D, Lauret E, et al. Nitric oxide and calcium participate in the fine regulation of mitochondrial biogenesis in follicular thyroid carcinoma cells. J Biol Chem. 2011;286:18229-39 pubmed publisher..This is the first demonstration that NO and calcium regulate mitochondrial biogenesis through the PRC pathway in thyroid cell lines. ..
- Etienne A, Genard M, Lobit P, Mbéguié A Mbéguié D, Bugaud C. What controls fleshy fruit acidity? A review of malate and citrate accumulation in fruit cells. J Exp Bot. 2013;64:1451-69 pubmed publisher..This review sheds light on the interactions between these factors and the metabolism and storage of organic acids in the cell. ..
- Paul C, Manero F, Gonin S, Kretz Remy C, Virot S, Arrigo A. Hsp27 as a negative regulator of cytochrome C release. Mol Cell Biol. 2002;22:816-34 pubmed..Moreover, in etoposide-treated cells, Hsp27 still delayed the release of cytochrome c from mitochondria and Bid intracellular redistribution in conditions where F-actin was not altered. ..
- Mouillon J, Ravanel S, Douce R, Rebeille F. Folate synthesis in higher-plant mitochondria: coupling between the dihydropterin pyrophosphokinase and the dihydropteroate synthase activities. Biochem J. 2002;363:313-9 pubmed..Thus the HPPK domain of this bifunctional protein is the limiting factor of the overall reaction, but the DHPS domain is a potential key regulatory point of the whole folate biosynthetic pathway. ..
- Sohm B, Sissler M, Park H, King M, Florentz C. Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase. J Mol Biol. 2004;339:17-29 pubmed..Leucyl-tRNA synthetase contacts tRNA(Leu(UUR)) in the amino acid acceptor stem, the anticodon stem, and the D-loop, which is unprecedented for a leucine aminoacylation system. ..
- Lorin S, Dufour E, Sainsard Chanet A. Mitochondrial metabolism and aging in the filamentous fungus Podospora anserina. Biochim Biophys Acta. 2006;1757:604-10 pubmed..anserina for studying lifespan regulation...
- Martelli A, Wattenhofer Donzé M, Schmucker S, Bouvet S, Reutenauer L, Puccio H. Frataxin is essential for extramitochondrial Fe-S cluster proteins in mammalian tissues. Hum Mol Genet. 2007;16:2651-8 pubmed..These results thus provide new cellular pathways that may contribute to molecular mechanisms of the disease. ..
- Castera L, Hatzfeld Charbonnier A, Ballot C, Charbonnel F, Dhuiege E, Velu T, et al. Apoptosis-related mitochondrial dysfunction defines human monocyte-derived dendritic cells with impaired immuno-stimulatory capacities. J Cell Mol Med. 2009;13:1321-35 pubmed publisher..These data indicate a strong requirement for mitochondrial integrity for the immuno-stimulatory capacities of DC. Determining Delta psi m could be a useful parameter to select 'fully' functional DCs for anti-tumour vaccines. ..
- Germot A, Philippe H, Le Guyader H. Evidence for loss of mitochondria in Microsporidia from a mitochondrial-type HSP70 in Nosema locustae. Mol Biochem Parasitol. 1997;87:159-68 pubmed..Loss of mitochondria, now demonstrated for several amitochondriate groups, indicates that the common ancestor of all the extant eukaryotic species could have been a mitochondriate eukaryote...
- Degoul F, Brulé H, Cepanec C, Helm M, Marsac C, Leroux J, et al. Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene. Hum Mol Genet. 1998;7:347-54 pubmed..The potential implications of these findings on the understanding of the molecular mechanisms involved in the expression of pathology are discussed. ..
- Rohou H, Francisci S, Rinaldi T, Frontali L, Bolotin Fukuhara M. Reintroduction of a characterized Mit tRNA glycine mutation into yeast mitochondria provides a new tool for the study of human neurodegenerative diseases. Yeast. 2001;18:219-27 pubmed..The method will provide important applications for the use of yeast as a model system of human mitochondrial pathologies. ..
- Mazat J, Rossignol R, Malgat M, Rocher C, Faustin B, Letellier T. What do mitochondrial diseases teach us about normal mitochondrial functions...that we already knew: threshold expression of mitochondrial defects. Biochim Biophys Acta. 2001;1504:20-30 pubmed..This could bring an explanation for the diseases observed in conditions where the mitochondrial rate of ATP synthesis is only slightly affected. ..
- Cuisnier O, Serduc R, Lavieille J, Longuet M, Reyt E, Riva C. Chronic hypoxia protects against gamma-irradiation-induced apoptosis by inducing bcl-2 up-regulation and inhibiting mitochondrial translocation and conformational change of bax protein. Int J Oncol. 2003;23:1033-41 pubmed
- Duvezin Caubet S, Rak M, Lefebvre Legendre L, Tetaud E, Bonnefoy N, di Rago J. A "petite obligate" mutant of Saccharomyces cerevisiae: functional mtDNA is lethal in cells lacking the delta subunit of mitochondrial F1-ATPase. J Biol Chem. 2006;281:16305-13 pubmed..This is the first report of what we have called a "petite obligate" mutant of S. cerevisiae. ..
- Valmalette J, Dombrovsky A, Brat P, Mertz C, Capovilla M, Robichon A. Light- induced electron transfer and ATP synthesis in a carotene synthesizing insect. Sci Rep. 2012;2:579 pubmed publisher..This appears as an archaic photosynthetic system consisting of photo-emitted electrons that are in fine funnelled into the mitochondrial reducing power in order to synthesize ATP molecules. ..
- Loeffler M, Daugas E, Susin S, Zamzami N, Metivier D, Nieminen A, et al. Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor. FASEB J. 2001;15:758-67 pubmed..AIF Delta 1-100-induced cell death is suppressed by neither Z-VAD.fmk or by Bcl-2. Thus, extramitochondrially targeted AIF is a dominant cell death inducer. ..
- Bernard D, Monte D, Vandenbunder B, Abbadie C. The c-Rel transcription factor can both induce and inhibit apoptosis in the same cells via the upregulation of MnSOD. Oncogene. 2002;21:4392-402 pubmed..These results indicate that the anti- and pro-apoptotic effects of Rel/NF-kappaB factors are not necessarily alternative but can occur successively in the same cell, via the up-regulation of the same target gene. ..
- Behm Ansmant I, Branlant C, Motorin Y. The Saccharomyces cerevisiae Pus2 protein encoded by YGL063w ORF is a mitochondrial tRNA:Psi27/28-synthase. RNA. 2007;13:1641-7 pubmed
- Desquiret V, Gueguen N, Malthiery Y, Ritz P, Simard G. Mitochondrial effects of dexamethasone imply both membrane and cytosolic-initiated pathways in HepG2 cells. Int J Biochem Cell Biol. 2008;40:1629-41 pubmed publisher..We concluded that mitochondria are the target of multiple dexamethasone-induced regulatory pathways that are set up gradually after the beginning of hormone exposure and that durably influence mitochondrial oxidative phosphorylation. ..
- Lapasset L, Milhavet O, Prieur A, Besnard E, Babled A, Aït Hamou N, et al. Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. Genes Dev. 2011;25:2248-53 pubmed publisher..These results provide new insights into iPSC technology and pave the way for regenerative medicine for aged patients. ..
- Eidi H, Joubert O, Nemos C, Grandemange S, Mograbi B, Foliguet B, et al. Drug delivery by polymeric nanoparticles induces autophagy in macrophages. Int J Pharm. 2012;422:495-503 pubmed publisher..Although toxicity of nanoparticles has already been evidenced, it is the first time that results show clearly that the toxicity of polymeric nanovectors may be related to an activation of autophagy. ..
- Dubrez L, Coll J, Hurbin A, Solary E, Favrot M. Caffeine sensitizes human H358 cell line to p53-mediated apoptosis by inducing mitochondrial translocation and conformational change of BAX protein. J Biol Chem. 2001;276:38980-7 pubmed..All together, caffeine synergizes with p53 for inducing cell death through a cell cycle-independent mechanism, involving mitochondrial translocation and conformational change of BAX protein. ..
- Théobald Dietrich A, Frugier M, Giege R, Rudinger Thirion J. Atypical archaeal tRNA pyrrolysine transcript behaves towards EF-Tu as a typical elongator tRNA. Nucleic Acids Res. 2004;32:1091-6 pubmed
- Bedhomme M, Hoffmann M, McCarthy E, Gambonnet B, Moran R, Rebeille F, et al. Folate metabolism in plants: an Arabidopsis homolog of the mammalian mitochondrial folate transporter mediates folate import into chloroplasts. J Biol Chem. 2005;280:34823-31 pubmed
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