Genomes and Genes
Experts and Doctors on mice in United Kingdom
Locale: United Kingdom
Publications473 found, 100 shown here
- Lowell S, Benchoua A, Heavey B, Smith A. Notch promotes neural lineage entry by pluripotent embryonic stem cells. PLoS Biol. 2006;4:e121 pubmed..Limiting activation of endogenous Notch results in heterogeneous lineage commitment. Manipulation of Notch signalling is therefore likely to be a key factor in taking command of ES cell lineage choice. ..
- Croft D, Olson M. The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms. Mol Cell Biol. 2006;26:4612-27 pubmed..Therefore, the influence of ROCK on cell cycle regulatory proteins occurs by multiple independent mechanisms. ..
- Leese M, Leblond B, Smith A, Newman S, Di Fiore A, De Simone G, et al. 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem. 2006;49:7683-96 pubmed..2-Substituted E2bisMATEs are attractive candidates for further development as multitargeted anticancer agents...
- Entrican G, Wattegedera S, Rocchi M, Wheelhouse N. Pregnancy, indoleamine 2,3-dioxygenase (IDO) and chlamydial abortion: an unresolved paradox. Vet Microbiol. 2009;135:98-102 pubmed publisher..This paradox is discussed in the context of immune modulation during pregnancy, tryptophan biosynthesis by Chlamydiaceae and differences in placental structures between sheep, humans and mice. ..
- Holmes M, Carter R, Noble J, Chitnis S, Dutia A, Paterson J, et al. 11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments. J Neurosci. 2010;30:6916-20 pubmed publisher..Thus, excess 11beta-HSD1 in forebrain is a cause of as well as a therapeutic target in memory impairments with aging. ..
- Parfitt D, Zernicka Goetz M. Epigenetic modification affecting expression of cell polarity and cell fate genes to regulate lineage specification in the early mouse embryo. Mol Biol Cell. 2010;21:2649-60 pubmed publisher..These results demonstrate how the extent of a specific epigenetic modification could affect expression of cell polarity and fate-determining genes to ensure lineage allocation in the mouse embryo. ..
- Thakker R. Multiple endocrine neoplasia type 1 (MEN1). Best Pract Res Clin Endocrinol Metab. 2010;24:355-70 pubmed publisher..The majority of MEN1 mutations are likely to disrupt the interactions of Menin with other proteins and thereby alter critical events in cell cycle regulation and proliferation...
- Al Sabbagh M, Fusi L, Higham J, Lee Y, Lei K, Hanyaloglu A, et al. NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling. Endocrinology. 2011;152:730-40 pubmed publisher..Thus, NOX-4 activation and reactive oxygen species signaling play an integral role in initiating the endometrial decidual response in preparation of pregnancy...
- Xiao Q, Wang G, Yin X, Luo Z, Margariti A, Zeng L, et al. Chromobox protein homolog 3 is essential for stem cell differentiation to smooth muscles in vitro and in embryonic arteriogenesis. Arterioscler Thromb Vasc Biol. 2011;31:1842-52 pubmed publisher..Our findings suggest that the interaction between Cbx3 and Dia-1/SRF is essential for SMC differentiation from stem cells and for the development of functional cardiovascular system. ..
- Selvadurai H, Mason J. Wnt/Î²-catenin signalling is active in a highly dynamic pattern during development of the mouse cerebellum. PLoS ONE. 2011;6:e23012 pubmed publisher..These results indicate a variety of potential functions for Wnt/Î²-catenin activity during cerebellum development. ..
- Bay V, Butt A. Relationship between glial potassium regulation and axon excitability: a role for glial Kir4.1 channels. Glia. 2012;60:651-60 pubmed publisher..Glial Kir have increasing importance in K(+) clearance at higher levels of axonal activity, helping to maintain the physiological [K(+)](o) ceiling and ensure the fidelity of signaling between the retina and brain. ..
- West E, Gonzalez Cordero A, Hippert C, Osakada F, Martinez Barbera J, Pearson R, et al. Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem Cells. 2012;30:1424-35 pubmed publisher..Despite showing expression profiles characteristic of immature photoreceptors, the ESC-derived precursors generated using this protocol did not display transplantation competence equivalent to precursors from the postnatal retina. ..
- Boonrungsiman S, Gentleman E, Carzaniga R, Evans N, McComb D, Porter A, et al. The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation. Proc Natl Acad Sci U S A. 2012;109:14170-5 pubmed publisher..These observations may have important implications in deciphering both how normal bone forms and in understanding pathological mineralization. ..
- Lee C, Mudaliar M, Haggart D, Wolf C, Miele G, Vass J, et al. Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology. PLoS ONE. 2012;7:e48238 pubmed publisher..Overall, the algorithm shows promise for early detection of toxicity in the drug discovery process. ..
- Galea G, Meakin L, Sugiyama T, Zebda N, Sunters A, Taipaleenmaki H, et al. Estrogen receptor ? mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor ?. J Biol Chem. 2013;288:9035-48 pubmed publisher..ER-targeting therapy may facilitate structurally appropriate bone formation by enhancing the distinct ligand-independent, strain-related contributions to proliferation of both ER? and ER?. ..
- Hoerder Suabedissen A, Oeschger F, Krishnan M, Belgard T, Wang W, Lee S, et al. Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia. Proc Natl Acad Sci U S A. 2013;110:3555-60 pubmed publisher..Our report emphasizes the importance of the study of transient features of the developing brain to better understand neurodevelopmental disorders. ..
- Roversi P, Ryffel B, Togbe D, Maillet I, Teixeira M, Ahmat N, et al. Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury. J Biol Chem. 2013;288:18789-802 pubmed publisher..The findings suggest that dual inhibition of C5 and LTB4 may be useful for treatment of human immune complex-dependent diseases. ..
- Gwyer Findlay E, Danks L, Madden J, Cavanagh M, McNamee K, McCann F, et al. OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis. Proc Natl Acad Sci U S A. 2014;111:2289-94 pubmed publisher..This work shows that more targeted approaches may augment the "therapeutic window" and increase the benefit/risk in RA, and possibly other autoimmune diseases, and are thus worth testing in humans. ..
- Harvey A, Montezano A, Hood K, Lopes R, Ríos F, Ceravolo G, et al. Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: The aldosterone-mineralocorticoid receptor-Nox1 axis. Life Sci. 2017;179:110-119 pubmed publisher..Our findings suggest that aldosterone, which is increased in SHRSP, induces vascular damage through MR-Nox1-p66Shc-mediated processes that modulate pro-fibrotic and pro-inflammatory signaling pathways. ..
- Whiteland J, Nicholls S, Shimeld C, Easty D, Williams N, Hill T. Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. J Histochem Cytochem. 1995;43:313-20 pubmed
- Jones A, Korpi E, McKernan R, Pelz R, Nusser Z, Mäkelä R, et al. Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression. J Neurosci. 1997;17:1350-62 pubmed..Because in alpha6 -/- neurons the remaining alpha1, beta2/3, and gamma2 subunits cannot rescue the delta subunit, certain potential subunit combinations may not be found in wild-type cells. ..
- Xu C, Chambers J, Solomon E. Complex regulation of the BRCA1 gene. J Biol Chem. 1997;272:20994-7 pubmed..We also discerned that there are striking differences in both the genomic organization and immediate cis-control elements of the BRCA1 gene between humans and mice. ..
- Parry C, Simas J, Smith V, Stewart C, Minson A, Efstathiou S, et al. A broad spectrum secreted chemokine binding protein encoded by a herpesvirus. J Exp Med. 2000;191:573-8 pubmed..hvCKBP is the first soluble chemokine receptor identified in herpesviruses; it represents a novel protein structure with the ability to bind all subfamilies of chemokines in solution and has potential therapeutic applications...
- Tümpel S, Sanz Ezquerro J, Isaac A, Eblaghie M, Dobson J, Tickle C. Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development. Dev Biol. 2002;250:251-62 pubmed..Anterior Tbx3 expression appears to be related to the width of limb bud, which determines digit number. ..
- Daneshvar H, Coombs G, Hagan P, Phillips R. Leishmania mexicana and Leishmania major: attenuation of wild-type parasites and vaccination with the attenuated lines. J Infect Dis. 2003;187:1662-8 pubmed..mexicana retained its properties in gentamicin-free medium over 40 subcultures. The attenuated lines of L. mexicana and L. major both induced significant protection in mice against challenge with wild-type parasites. ..
- Tsuboi T, Da Silva Xavier G, Leclerc I, Rutter G. 5'-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics. J Biol Chem. 2003;278:52042-51 pubmed
- McMahon S, Wood J. Increasingly irritable and close to tears: TRPA1 in inflammatory pain. Cell. 2006;124:1123-5 pubmed..In contrast, mechano- and thermosensation are normal in TRPA1-deficient mice. ..
- Vellani V, Colucci M, Lattanzi R, Giannini E, Negri L, Melchiorri P, et al. Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8. J Neurosci. 2006;26:5109-16 pubmed..The results suggest a role for prokineticins in physiological inflammation and hyperalgesia. ..
- Wood J, Schneider H, Rudd C. TcR and TcR-CD28 engagement of protein kinase B (PKB/AKT) and glycogen synthase kinase-3 (GSK-3) operates independently of guanine nucleotide exchange factor VAV-1. J Biol Chem. 2006;281:32385-94 pubmed..Both events are down-stream targets of Vav-1. Overall, our findings indicate that the TcR and TcR-CD28 driven PKB-GSK-3 pathway can operate independently of Vav-1 in T-cells. ..
- Hutchings C, Birkett A, Moore A, Hill A. Combination of protein and viral vaccines induces potent cellular and humoral immune responses and enhanced protection from murine malaria challenge. Infect Immun. 2007;75:5819-26 pubmed
- Oxley C, Anthis N, Lowe E, Vakonakis I, Campbell I, Wegener K. An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding. J Biol Chem. 2008;283:5420-6 pubmed..This switch may represent an in vivo mechanism for control of integrin receptor activation. These results have implications for the control of integrin signaling by proteins containing phosphotyrosine binding domains. ..
- Bowers S, Mirabella F, Calero Nieto F, Valeaux S, Hadjur S, Baxter E, et al. A conserved insulator that recruits CTCF and cohesin exists between the closely related but divergently regulated interleukin-3 and granulocyte-macrophage colony-stimulating factor genes. Mol Cell Biol. 2009;29:1682-93 pubmed publisher..We suggest that one important role of these sites is to enable the independent regulation of the IL-3 and GM-CSF genes. ..
- Prestwich R, Ilett E, Errington F, Diaz R, Steele L, Kottke T, et al. Immune-mediated antitumor activity of reovirus is required for therapy and is independent of direct viral oncolysis and replication. Clin Cancer Res. 2009;15:4374-4381 pubmed publisher..The immune response is critical in mediating the efficacy of reovirus, and does not depend upon direct viral oncolysis or replication. The findings are of direct relevance to fulfilling the potential of this novel anticancer agent. ..
- Brady S, Coleman M, Munro J, Feller S, Morrice N, Olson M. Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation. Cancer Res. 2009;69:6773-81 pubmed publisher..Instead, the active kinase conformation induced by oncogenic mutation prevents Sprouty2 binding. These results reveal a dual mechanism that affects the Sprouty2/B-Raf interaction: Sprouty phosphorylation and B-Raf conformation. ..
- Pike R, Filby A, Ploquin M, Eksmond U, Marques R, Antunes I, et al. Race between retroviral spread and CD4+ T-cell response determines the outcome of acute Friend virus infection. J Virol. 2009;83:11211-22 pubmed publisher..Thus, these results suggest that FV-specific CD4(+) T cells provide significant direct protection against acute FV infection, the extent of which critically depends on the ratio of FV-infected cells to FV-specific CD4(+) T cells...
- Arthur Farraj P, Wanek K, Hantke J, Davis C, Jayakar A, Parkinson D, et al. Mouse schwann cells need both NRG1 and cyclic AMP to myelinate. Glia. 2011;59:720-33 pubmed publisher..They demonstrate unambiguously the promyelin effects of NRG1 in purified cells, and they show that the cAMP pathway determines whether NRG1 drives proliferation or induces myelin differentiation...
- Stroud M, Kammerer R, Ballestrem C. Characterization of G2L3 (GAS2-like 3), a new microtubule- and actin-binding protein related to spectraplakins. J Biol Chem. 2011;286:24987-95 pubmed publisher..Furthermore, we show that tubulin acetylation drives GAS2-like 3 localization to MTs and may provide functional insights into the role of GAS2-like 3. ..
- Evans C, Humphries J, Waltham M, Saha P, Mattock K, Patel A, et al. Upregulation of hypoxia-inducible factor 1 alpha in local vein wall is associated with enhanced venous thrombus resolution. Thromb Res. 2011;128:346-51 pubmed publisher..Stimulating HIF1? levels in the vein wall leads to an increased angiogenic drive and promotes vein recanalisation and thrombus resolution. ..
- Morton N, Nelson Y, Michailidou Z, Di Rollo E, Ramage L, Hadoke P, et al. A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes. PLoS ONE. 2011;6:e23944 pubmed publisher..A focussed candidate gene enrichment strategy in the unique F and L model has identified novel adipose tissue-enriched genes contributing to obesity. ..
- M ller C, Conejero L, Spink N, Wand M, Bancroft G, Titball R. Role of RelA and SpoT in Burkholderia pseudomallei virulence and immunity. Infect Immun. 2012;80:3247-55 pubmed publisher..pseudomallei, and the ?relA ?spoT mutant may be a promising live-attenuated vaccine candidate...
- Neher J, Emmrich J, Fricker M, Mander P, Thery C, Brown G. Phagocytosis executes delayed neuronal death after focal brain ischemia. Proc Natl Acad Sci U S A. 2013;110:E4098-107 pubmed publisher..Therefore, inhibition of specific phagocytic pathways may present therapeutic targets for preventing delayed neuronal loss after transient cerebral ischemia. ..
- Attridge K, Kenefeck R, Wardzinski L, Qureshi O, Wang C, Manzotti C, et al. IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells. J Immunol. 2014;192:2195-201 pubmed publisher..These data pinpoint CD86 upregulation as an additional mechanism by which IL-21 can elicit immunomodulatory effects. ..
- Kantidakis T, Saponaro M, Mitter R, Horswell S, Kranz A, Boeing S, et al. Mutation of cancer driver MLL2 results in transcription stress and genome instability. Genes Dev. 2016;30:408-20 pubmed publisher..The requirement for MLL2 in the maintenance of genome stability in genes helps explain its widespread role in cancer and points to transcription stress as a strong driver in tumorigenesis. ..
- Zervou S, Whittington H, Ostrowski P, Cao F, Tyler J, Lake H, et al. Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro. PLoS ONE. 2017;12:e0182994 pubmed publisher..These findings support increased CK activity as protection against ischaemia-reperfusion injury, in particular, protection via CKMT2 in a cardiac-relevant cell line, which merits further investigation in vivo. ..
- Sun Y, Lacour S, Brooks R, Rushton N, Fawcett J, Cameron R. Assessment of the biocompatibility of photosensitive polyimide for implantable medical device use. J Biomed Mater Res A. 2009;90:648-55 pubmed publisher..Schwann cell appearance was similar on each of the PIs and the PSPI tested. The results suggest that PSPIs may have potential use for biological microsystem and neuroprosthetic applications. ..
- Kerscher S, Glenister P, Favor J, Lyon M. Two new cataract loci, Ccw and To3, and further mapping of the Npp and Opj cataracts in the mouse. Genomics. 1996;36:17-21 pubmed..While there are no obvious candidate genes in the vicinity of the Ccw, Npp, and Opj mutations, To3 lies remarkably close to the recently mapped Lim2 locus, which encodes lens intrinsic membrane protein 2, also called MP19. ..
- Bishop K, Bock M, Towers G, Stoye J. Identification of the regions of Fv1 necessary for murine leukemia virus restriction. J Virol. 2001;75:5182-8 pubmed..Binding specificity appeared to be a combinatorial property of a number of residues within the C-terminal portion of Fv1. ..
- Zhu D, Qi C, Morse H, Janz S, Stevenson F. Deregulated expression of the Myc cellular oncogene drives development of mouse "Burkitt-like" lymphomas from naive B cells. Blood. 2005;105:2135-7 pubmed..In contrast, human eBL development occurs in a GC or post-GC site with a likely contribution to pathogenesis from Epstein-Barr virus (EBV) and other epigenetic factors. ..
- Levy L, Howell M, Das D, Harkin S, Episkopou V, Hill C. Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Mol Cell Biol. 2007;27:6068-83 pubmed..Reintroduction of wild-type Arkadia restores TGF-beta-induced Smad3/Smad4-dependent transcription and SnoN degradation in these cells, raising the possibility that loss of Arkadia function may be relevant in cancer. ..
- Kikyo N, Williamson C, John R, Barton S, Beechey C, Ball S, et al. Genetic and functional analysis of neuronatin in mice with maternal or paternal duplication of distal Chr 2. Dev Biol. 1997;190:66-77 pubmed
- Nichols R, Campbell B, Smith H. Molecular fingerprinting of Cryptosporidium oocysts isolated during water monitoring. Appl Environ Microbiol. 2006;72:5428-35 pubmed..muris or C. andersoni, C. hominis or C. parvum, and C. meleagridis or Cryptosporidium sp. cervine, ferret, and mouse genotypes. Oocysts on one slide contained Cryptosporidium muskrat genotype II DNA. ..
- Kearney L, Gonzalez De Castro D, Yeung J, Procter J, Horsley S, Eguchi Ishimae M, et al. Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia. Blood. 2009;113:646-8 pubmed publisher..These results infer a complex molecular pathogenesis for DS-ALL leukemogenesis, with trisomy 21 as an initiating or first hit and with chromosome aneuploidy, gene deletions, and activating JAK2 mutations as complementary genetic events. ..
- Clegg J, Conway C, Howe K, Price D, Mason J, Turnbull J, et al. Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development. J Neurosci. 2014;34:2389-401 pubmed publisher..Overall, our data fit a model in which Hs2st and Hs6st1 normally generate conditions conducive to CC development by generating an HS-containing environment that keeps Erk signaling in check. ..
- Morten I, Gosal W, Radford S, Hewitt E. Investigation into the role of macrophages in the formation and degradation of beta2-microglobulin amyloid fibrils. J Biol Chem. 2007;282:29691-700 pubmed
- Portella G, Cumming S, Liddell J, Cui W, Ireland H, Akhurst R, et al. Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Cell Growth Differ. 1998;9:393-404 pubmed
- Dangerfield J, Larbi K, Huang M, Dewar A, Nourshargh S. PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane. J Exp Med. 2002;196:1201-11 pubmed
- Richards C, Case R, Hirst T, Hill T, Williams N. Protection against recurrent ocular herpes simplex virus type 1 disease after therapeutic vaccination of latently infected mice. J Virol. 2003;77:6692-9 pubmed..The possible immune mechanisms involved in protection against recurrent ocular herpetic disease in therapeutically vaccinated animals are discussed. ..
- Daunt M, Dale O, Smith P. Somatostatin inhibits oxidative respiration in pancreatic beta-cells. Endocrinology. 2006;147:1527-35 pubmed..This represents a new signaling pathway by which somatostatin can inhibit cellular functions regulated by glucose metabolism. ..
- Wang H, Peters N, Schwarze J. Plasmacytoid dendritic cells limit viral replication, pulmonary inflammation, and airway hyperresponsiveness in respiratory syncytial virus infection. J Immunol. 2006;177:6263-70 pubmed..In addition to this innate response, pDC also may play an immune regulatory role in reducing pulmonary inflammation and inhibiting the development of airway hyperresponsiveness. ..
- Kwok C, Zeisig B, Dong S, So C. Forced homo-oligomerization of RARalpha leads to transformation of primary hematopoietic cells. Cancer Cell. 2006;9:95-108 pubmed..Taken together, these findings endorse an oligomerization-dependent mechanism for RARalpha-mediated transformation and suggest a potential avenue for molecular therapy. ..
- Mallya M, Campbell R, Aguado B. Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands. Protein Sci. 2006;15:2244-56 pubmed..This characterization of the five MHC class III region Ly-6 family members is of great relevance, as they represent 18% of the human Ly-6 protein family and 50% of the secreted ones. ..
- Eöry L, Halligan D, Keightley P. Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomes. Mol Biol Evol. 2010;27:177-92 pubmed publisher..Including coding and noncoding sites, we estimate that the genomic deleterious mutation rate U = 4.2. The mutational load predicted under a multiplicative model is therefore about 99% in hominids. ..
- Shaw A, Ratinier M, Nunes S, Nomikou K, Caporale M, Golder M, et al. Reassortment between two serologically unrelated bluetongue virus strains is flexible and can involve any genome segment. J Virol. 2013;87:543-57 pubmed publisher..Given the propensity of BTV to reassort, it is increasingly important to have an alternative classification system for orbiviruses...
- Skamagki M, Wicher K, Jedrusik A, Ganguly S, Zernicka Goetz M. Asymmetric localization of Cdx2 mRNA during the first cell-fate decision in early mouse development. Cell Rep. 2013;3:442-57 pubmed publisher..We discuss how the asymmetric localization and segregation of Cdx2 transcripts could contribute to multiple mechanisms that establish different cell fates in the mouse embryo. ..
- Gaisford W, Pritchard D, Cooke A. OdDHL inhibits T cell subset differentiation and delays diabetes onset in NOD mice. Clin Vaccine Immunol. 2011;18:1213-20 pubmed publisher..OdDHL was shown to have no effect on the inhibition of primed and committed differentiated T cell responses, suggesting that that immune mechanism mediated by this molecule may be more restricted to initial stages of infection. ..
- Burgoyne J, Prysyazhna O, Richards D, Eaton P. Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG IÎ± (Protein Kinase G IÎ±). Hypertension. 2017;70:577-586 pubmed publisher..These studies, therefore, provide validation of PKG IÎ± C42 as the target of G1, as well as proof-of-principle for a new class of antihypertensive drugs that have potential for further development for clinical use in humans. ..
- Kirkland D, Beevers C. Induction of LacZ mutations in Muta Mouse can distinguish carcinogenic from non-carcinogenic analogues of diaminotoluenes and nitronaphthalenes. Mutat Res. 2006;608:88-96 pubmed..Robust carcinogenicity data are needed to determine whether 2-NNT can induce tumours in the liver and bladder...
- Krutskikh A, De Gendt K, Sharp V, Verhoeven G, Poutanen M, Huhtaniemi I. Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia. Endocrinology. 2011;152:689-96 pubmed publisher..The phenotype of the produced knockout mouse provides a novel model for obstructive azoospermia...
- Sembongi H, Miranda M, Han G, Fakas S, Grimsey N, Vendrell J, et al. Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells. J Biol Chem. 2013;288:34502-13 pubmed publisher..We propose that in addition to their roles during early adipogenesis, lipins also have a role in lipid droplet biogenesis. ..
- Marchese F, Aubareda A, Tudor C, Saklatvala J, Clark A, Dean J. MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment. J Biol Chem. 2010;285:27590-600 pubmed publisher..Cyclooxygenase-2 mRNA stability is increased in CAF1-depleted cells in which it is no longer p38 MAPK/MK2-regulated. ..
- Leonard L, Horton C, Maden M, Pizzey J. Anteriorization of CRABP-I expression by retinoic acid in the developing mouse central nervous system and its relationship to teratogenesis. Dev Biol. 1995;168:514-28 pubmed..The role that CRABP-I may play in normal development of the hindbrain and in teratogenesis and the similarity of these results to those obtained with various Hox genes are discussed. ..
- Izcue A, Hue S, Buonocore S, Arancibia Cárcamo C, Ahern P, Iwakura Y, et al. Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity. 2008;28:559-70 pubmed publisher..Taken together, our data indicate that overriding immunosuppressive pathways is an important function of IL-23 in the intestine and could influence not only Th17 cell activity but also other types of immune responses. ..
- Wolfart J, Roeper J. Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons. J Neurosci. 2002;22:3404-13 pubmed..The functional coupling of SK to T-type channels has important implications for the temporal integration of synaptic input and might help to understand how DA neurons switch between pacemaker and burst-firing modes in vivo. ..
- Verhagen J, Genolet R, Britton G, Stevenson B, Sabatos Peyton C, Dyson J, et al. CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire. Proc Natl Acad Sci U S A. 2013;110:E221-30 pubmed publisher..CTLA-4, therefore, regulates the early development of self-reactive T cells in the thymus and plays a key role in central tolerance. ..
- Guillen C, McInnes I, Vaughan D, Kommajosyula S, van Berkel P, Leung B, et al. Enhanced Th1 response to Staphylococcus aureus infection in human lactoferrin-transgenic mice. J Immunol. 2002;168:3950-7 pubmed..These results demonstrate that human Lf can mediate both antimicrobial and immunomodulatory activities with downstream effects on the outcome of immune pathology in infectious and inflammatory disease. ..
- Gadhavi P, Greenwood M, Strom M, King I, Buxton R. The regulatory region of the human desmocollin 3 promoter forms a DNA four-way junction. Biochem Biophys Res Commun. 2001;281:520-8 pubmed
- Allinson K, Carvalho R, van den Brink S, Mummery C, Arthur H. Generation of a floxed allele of the mouse Endoglin gene. Genesis. 2007;45:391-5 pubmed..Mice homozygous for this allele are normal and in the presence of appropriate Cre lines will allow time and cell specific Endoglin deletion for in vivo analysis of function in cardiovascular development and disease. ..
- Dietrich I, McMonagle E, Petit S, Vijayakrishnan S, Logan N, Chan C, et al. Feline tetherin efficiently restricts release of feline immunodeficiency virus but not spreading of infection. J Virol. 2011;85:5840-52 pubmed publisher..Accordingly, tetherin expression in vivo may promote the selective expansion of viral variants capable of more efficient cell-to-cell spread...
- Tian L, Coghill L, McClafferty H, MacDonald S, Antoni F, Ruth P, et al. Distinct stoichiometry of BKCa channel tetramer phosphorylation specifies channel activation and inhibition by cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 2004;101:11897-902 pubmed..This essentially digital regulation has important implications for the combinatorial and conditional regulation of BK(Ca) channels by reversible protein phosphorylation. ..
- Pallier P, Maywood E, Zheng Z, Chesham J, Inyushkin A, Dyball R, et al. Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease. J Neurosci. 2007;27:7869-78 pubmed
- Finn R, McLaughlin L, Ronseaux S, Rosewell I, Houston J, Henderson C, et al. Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. J Biol Chem. 2008;283:31385-93 pubmed publisher..6-fold in hepatic microsomal cytochrome b5 null mice. These data indicate that microsomal cytochrome b5 can play a major role in the in vivo metabolism of certain drugs and chemicals but in a P450- and substrate-dependent manner. ..