Experts and Doctors on mice in United Kingdom

Summary

Locale: United Kingdom
Topic: mice

Top Publications

  1. Tebbutt S, Wardle C, Hill D, Harris A. Molecular analysis of the ovine cystic fibrosis transmembrane conductance regulator gene. Proc Natl Acad Sci U S A. 1995;92:2293-7 pubmed
    ..Further, the developmental expression of CFTR in the sheep is equivalent to that observed in humans. Thus, overall a CF sheep should show lung pathology similar to that of humans with CF. ..
  2. Linardopoulos S, Street A, Quelle D, Parry D, Peters G, Sherr C, et al. Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors. Cancer Res. 1995;55:5168-72 pubmed
    ..Therefore, deletion or altered regulation of p16INK4a and p15INK4b occur concomitantly with the loss of differentiation associated with the late spindle stage of tumor progression in mouse skin. ..
  3. Moore T, Constancia M, Zubair M, Bailleul B, Feil R, Sasaki H, et al. Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2. Proc Natl Acad Sci U S A. 1997;94:12509-14 pubmed
    ..Our results support the proposal that tandem repeats act to target methylation to imprinted genetic loci. ..
  4. Yamada Y, Pannell R, Forster A, Rabbitts T. The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice. Proc Natl Acad Sci U S A. 2000;97:320-4 pubmed
    ..Thus, Lmo2-mediated transcription complexes not only regulate distinct phases of hematopoiesis but also angiogenesis, presumably by Lmo2 interacting with distinct partners in the different settings. ..
  5. Zernicka Goetz M, Pines J. Use of Green Fluorescent Protein in mouse embryos. Methods. 2001;24:55-60 pubmed
    ..In this article we outline the ways in which we have used GFP mRNA and cDNA in our studies of mouse cell lineages, and to characterize the behavior of proteins within the embryos. ..
  6. Cafferty W, Gardiner N, Gavazzi I, Powell J, McMahon S, Heath J, et al. Leukemia inhibitory factor determines the growth status of injured adult sensory neurons. J Neurosci. 2001;21:7161-70 pubmed
    ..LIF is also functionally protective to peptidergic sensory neurons after nerve damage in vivo. Our results indicate that the alteration in intrinsic growth status of injured sensory neurons depends, at least in part, on LIF. ..
  7. Adams J. Thrombospondins: multifunctional regulators of cell interactions. Annu Rev Cell Dev Biol. 2001;17:25-51 pubmed
  8. Clayton E, Bardi G, Bell S, Chantry D, Downes C, Gray A, et al. A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med. 2002;196:753-63 pubmed
    ..p110delta function is required for BCR-mediated calcium flux, activation of phosphlipaseCgamma2, and Bruton's tyrosine kinase. Thus, p110delta plays a critical role in B cell homeostasis and function. ..
  9. Goodall J, Martinozzi S, Dexter T, Champeval D, Carreira S, Larue L, et al. Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. Mol Cell Biol. 2004;24:2915-22 pubmed
    ..These results, together with the observation that BRAF signaling also induces Brn-2 expression, reveal that Brn-2 is a focus for the convergence of two key melanoma-associated signaling pathways that are linked to cell proliferation. ..

More Information

Publications526 found, 100 shown here

  1. Lang V, Symons A, Watton S, Janzen J, Soneji Y, Beinke S, et al. ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. Mol Cell Biol. 2004;24:5235-48 pubmed
    ..Thus, optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105. Together, these data raise the possibility that ABIN-2 functions in the TLR4 signaling pathway which regulates TPL-2 activation. ..
  2. Emes R, Riley M, Laukaitis C, Goodstadt L, Karn R, Ponting C. Comparative evolutionary genomics of androgen-binding protein genes. Genome Res. 2004;14:1516-29 pubmed
    ..We propose a role for ABPalpha/beta/gamma proteins as pheromones, or in modulating odorant detection. This would account for the extraordinary adaptive evolution of these genes, and surrounding genomic regions, in murid rodents. ..
  3. Hicks A, Abbitt K, Dodd P, Ridger V, Hellewell P, Norman K. The anti-inflammatory effects of a selectin ligand mimetic, TBC-1269, are not a result of competitive inhibition of leukocyte rolling in vivo. J Leukoc Biol. 2005;77:59-66 pubmed
    ..We suggest that the in vivo effects of TBC-1269 may be mediated through E-selectin but do not appear to involve leukocyte rolling. ..
  4. Grainger D, Reckless J, McKilligin E. Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice. J Immunol. 2004;173:6366-75 pubmed
    ..Any similar reduction of apoE activity in humans may contribute to the pathogenesis of a wide range of chronic diseases including atherosclerosis, dementia, and osteoporosis. ..
  5. Denton C, Lindahl G, Khan K, Shiwen X, Ong V, Gaspar N, et al. Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k). J Biol Chem. 2005;280:16053-65 pubmed
    ..Our study demonstrates that altered high affinity TGFbeta receptor function may lead to ligand-dependent activation of downstream signaling, and provides further evidence of a pivotal role for sustained TGFbeta overactivity in fibrosis. ..
  6. Prosser H, Bradley A, Chesham J, Ebling F, Hastings M, Maywood E. Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei. Proc Natl Acad Sci U S A. 2007;104:648-53 pubmed
  7. Barr T, Brown S, Mastroeni P, Gray D. B cell intrinsic MyD88 signals drive IFN-gamma production from T cells and control switching to IgG2c. J Immunol. 2009;183:1005-12 pubmed publisher
    ..We also found that B cell intrinsic MyD88 signals are required for the production of natural Abs. The data emphasize the nonredundant role of B cells as programmers of T cell differentiation in vivo. ..
  8. Shibata A, Barton O, Noon A, Dahm K, Deckbar D, Goodarzi A, et al. Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest. Mol Cell Biol. 2010;30:3371-83 pubmed publisher
    ..The combined repair and checkpoint defects conferred by 53BP1 and MDC1 deficiency act synergistically to enhance chromosome breakage. ..
  9. Maywood E, Chesham J, O Brien J, Hastings M. A diversity of paracrine signals sustains molecular circadian cycling in suprachiasmatic nucleus circuits. Proc Natl Acad Sci U S A. 2011;108:14306-11 pubmed publisher
    ..Thus, a hierarchy of paracrine neuropeptidergic signals determines cell- and circuit-level circadian pacemaking in the SCN. ..
  10. Miletich I, Yu W, Zhang R, Yang K, Caixeta de Andrade S, Pereira S, et al. Developmental stalling and organ-autonomous regulation of morphogenesis. Proc Natl Acad Sci U S A. 2011;108:19270-5 pubmed publisher
  11. Patel N, Masaratana P, Diaz Castro J, Latunde Dada G, Qureshi A, Lockyer P, et al. BMPER protein is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice. J Biol Chem. 2012;287:4099-106 pubmed publisher
    ..Thus Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice. ..
  12. Brown N, Marjanović M, Lüders J, Stracker T, Costanzo V. Cep63 and cep152 cooperate to ensure centriole duplication. PLoS ONE. 2013;8:e69986 pubmed publisher
    ..These observations describe the requirement for Cep63 in maintaining centriole number in dividing mammalian cells and further establish the order of events in centriole formation. ..
  13. Zeng L, Wang G, Ummarino D, Margariti A, Xu Q, Xiao Q, et al. Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor ?2. J Biol Chem. 2013;288:31853-66 pubmed publisher
    ..The HD3?-induced EndMT was both PI3K/Akt- and TGF?2-dependent. This study provides the first evidence of the role of HDAC3 splicing in the maintenance of endothelial integrity. ..
  14. Martins M, McCarthy A, Baxendale R, Guichard S, Magno L, Kessaris N, et al. Tumor suppressor role of phospholipase C epsilon in Ras-triggered cancers. Proc Natl Acad Sci U S A. 2014;111:4239-44 pubmed publisher
  15. Cheung E, Lee P, Ceteci F, Nixon C, Blyth K, Sansom O, et al. Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes Dev. 2016;30:52-63 pubmed publisher
  16. Gaunt E, Wise H, Zhang H, Lee L, Atkinson N, Nicol M, et al. Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection. elife. 2016;5:e12735 pubmed publisher
    ..Increasing CpG dinucleotide frequencies represents a generic and potentially highly effective method for generating safe, highly immunoreactive vaccines. ..
  17. Terry R, Wells D. Histopathological Evaluation of Skeletal Muscle with Specific Reference to Mouse Models of Muscular Dystrophy. Curr Protoc Mouse Biol. 2016;6:343-363 pubmed publisher
    ..Muscles carefully processed using this protocol are suitable for further evaluation using immunohistochemistry, immunofluorescence, special histochemical stains, and immuoblotting. © 2016 by John Wiley & Sons, Inc. ..
  18. Tam S, Hasan S, Choi H, Brown L, Jagannath A, Hughes S, et al. Constant Light Desynchronizes Olfactory versus Object and Visuospatial Recognition Memory Performance. J Neurosci. 2017;37:3555-3567 pubmed publisher
    ..Moreover, such a dispersed network of dissociable circadian clocks may provide greater flexibility when faced with conflicting environmental signals (e.g., seasonal changes in photoperiod). ..
  19. Goto T, Monk M. Regulation of X-chromosome inactivation in development in mice and humans. Microbiol Mol Biol Rev. 1998;62:362-78 pubmed
    ..This article reviews the mechanisms underlying XCI and recent advances elucidating the functions of the Xist gene in mice and humans. ..
  20. Macrae A, Dutia B, Milligan S, Brownstein D, Allen D, Mistrikova J, et al. Analysis of a novel strain of murine gammaherpesvirus reveals a genomic locus important for acute pathogenesis. J Virol. 2001;75:5315-27 pubmed
    ..These results demonstrate that genetic elements at the left end of the unique region of the MHV-68 genome play vital roles in host evasion and are critical to the development of splenic pathology. ..
  21. Scotland R, Cohen M, Foster P, Lovell M, Mathur A, Ahluwalia A, et al. C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression. Proc Natl Acad Sci U S A. 2005;102:14452-7 pubmed
    ..These observations suggest that endothelial CNP might maintain an anti-atherogenic influence on the blood vessel wall and represent a target for therapeutic intervention in inflammatory cardiovascular disorders. ..
  22. Na J, Zernicka Goetz M. Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function. Curr Biol. 2006;16:1249-54 pubmed
    ..Thus, at least two pathways appear to be downstream of CDC42: one affecting the actin cytoskeleton and required for migration of the meiotic spindle, and a second affecting the spindle microtubules in which aPKCzeta plays a role. ..
  23. Musson J, Morton M, Walker N, Harper H, McNeill H, Williamson E, et al. Sequential proteolytic processing of the capsular Caf1 antigen of Yersinia pestis for major histocompatibility complex class II-restricted presentation to T lymphocytes. J Biol Chem. 2006;281:26129-35 pubmed publisher
  24. Lerner O, Davenport D, Patel P, Psatha M, Lieberam I, Guthrie S. Stromal cell-derived factor-1 and hepatocyte growth factor guide axon projections to the extraocular muscles. Dev Neurobiol. 2010;70:549-64 pubmed publisher
    ..HGF shows some specificity in preferentially enhancing development of the trochlear nerve. ..
  25. Iwagaki N, Miles G. Activation of group I metabotropic glutamate receptors modulates locomotor-related motoneuron output in mice. J Neurophysiol. 2011;105:2108-20 pubmed publisher
    ..Given that group I mGluR activation reduces motoneuron excitability, mGluRs may provide negative feedback control of motoneuron output, particularly during high levels of glutamatergic stimulation. ..
  26. Ninkina N, Privalova E, Pinon L, Davies A, Buchman V. Developmentally regulated expression of persyn, a member of the synuclein family, in skin. Exp Cell Res. 1999;246:308-11 pubmed
    ..This finding together with our recent observations that persyn influences neurofilament network integrity in sensory neurons raises the possibility that persyn in skin could be involved in modulation of the keratin network. ..
  27. Molina Holgado F, Pinteaux E, Moore J, Molina Holgado E, Guaza C, Gibson R, et al. Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia. J Neurosci. 2003;23:6470-4 pubmed
    ..These data suggest a novel neuroprotective mechanism of action for CBs in response to inflammatory or excitotoxic insults that is mediated by both CB1 and CB2 receptor-dependent pathways. ..
  28. Mesnard D, Filipe M, Belo J, Zernicka Goetz M. The anterior-posterior axis emerges respecting the morphology of the mouse embryo that changes and aligns with the uterus before gastrulation. Curr Biol. 2004;14:184-96 pubmed
    ..This suggests an interdependence between anterior-posterior gene expression, the shape of the embryo, and the uterus. ..
  29. Edgar A, Dover S, Lodrick M, McKay I, Hughes F, Turner W. Bone morphogenetic protein-2 induces expression of murine zinc finger transcription factor ZNF450. J Cell Biochem. 2005;94:202-15 pubmed
    ..However, ZNF450 mRNA was found also in a wide range of adult tissues. The consistent induction of ZNF450 by BMP-2 after 4 h in three murine pluripotent cell lines suggests that ZNF450 may play a role in the BMP-2 signalling pathway. ..
  30. Giavara S, Kosmidou E, Hande M, Bianchi M, Morgan A, d Adda di Fagagna F, et al. Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability. Curr Biol. 2005;15:68-72 pubmed
    ..Taken together, these data indicate that Nhp6A/B and Hmgb1 protect DNA from damaging agents and thus guard against the generation of genomic aberrations. ..
  31. Nandi M, Miller A, Stidwill R, Jacques T, Lam A, Haworth S, et al. Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse. Circulation. 2005;111:2086-90 pubmed
    ..This study demonstrates that mice deficient in GTP-CH1/BH4 display a pulmonary hypertensive but not systemic hypertensive phenotype. ..
  32. Sheader K, Vaughan S, Minchin J, Hughes K, Gull K, Rudenko G. Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes. Proc Natl Acad Sci U S A. 2005;102:8716-21 pubmed
  33. Turner J, Langley R, Johnston K, Egerton G, Wanji S, Taylor M. Wolbachia endosymbiotic bacteria of Brugia malayi mediate macrophage tolerance to TLR- and CD40-specific stimuli in a MyD88/TLR2-dependent manner. J Immunol. 2006;177:1240-9 pubmed
    ..Our data promote a role for Wolbachia in contributing toward the dysregulated and tolerized immunological phenotype that accompanies the majority of human filarial infections. ..
  34. Pattaradilokrat S, Cheesman S, Carter R. Linkage group selection: towards identifying genes controlling strain specific protective immunity in malaria. PLoS ONE. 2007;2:e857 pubmed
    ..c. chabaudi merozoite surface protein-1 protein. Other regions, including that containing the gene for P. c. chabaudi apical membrane antigen-1, may be more weakly associated with Strain Specific Protective Immunity in these parasites. ..
  35. Wijetunge L, Till S, Gillingwater T, Ingham C, Kind P. mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex. J Neurosci. 2008;28:13028-37 pubmed publisher
    ..Together these data indicate a key role for mGluR5 at both early and late stages of neuronal development in the trigeminal system of mice. ..
  36. Serrels A, Timpson P, Canel M, Schwarz J, Carragher N, Frame M, et al. Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development. Cancer Res. 2009;69:2714-9 pubmed publisher
    ..Furthermore, this work highlights critical differences in molecular dynamics in vitro and in vivo, which have important implications for the use of cultured disease models as surrogates for living tissue. ..
  37. Raby A, Le Bouder E, Colmont C, Davies J, Richards P, Coles B, et al. Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering. J Immunol. 2009;183:506-17 pubmed publisher
  38. Johnson M. From mouse egg to mouse embryo: polarities, axes, and tissues. Annu Rev Cell Dev Biol. 2009;25:483-512 pubmed publisher
    ..No final decision can be reached on a mechanism of action underlying any encoded information, but a cell interaction process model is preferred over one that relies solely on differential inheritance. ..
  39. Haque F, Mazzeo D, Patel J, Smallwood D, Ellis J, Shanahan C, et al. Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem. 2010;285:3487-98 pubmed publisher
    ..We propose that these different perturbations in lamin A-SUN protein interactions may underlie the opposing effects of EDMD and HGPS mutations on nuclear and cellular mechanics. ..
  40. Soderquest K, Walzer T, Zafirova B, Klavinskis L, Polic B, Vivier E, et al. Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses. J Immunol. 2011;186:3304-8 pubmed publisher
    ..The enhanced memory responses induced by the transient deletion of NK cells may provide a rational basis for the design of new vaccination strategies. ..
  41. Davis M, Abreu Goodger C, van Dongen S, Lu D, Tate P, Bartonicek N, et al. Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines. PLoS ONE. 2012;7:e41762 pubmed publisher
    ..Additionally, our experiments have revealed a novel candidate for Dgcr8-independent microRNA genesis and highlighted the challenges currently facing miRNA annotation. ..
  42. Duffy A, Holscher C. The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease. Neuroscience. 2013;228:294-300 pubmed publisher
    ..This finding shows that novel GIP analogues have the potential to be developed as novel therapeutics for Alzheimer's disease. ..
  43. Spender L, Carter M, O Brien D, Clark L, Yu J, Michalak E, et al. Transforming growth factor-? directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas. J Biol Chem. 2013;288:5198-209 pubmed publisher
    ..TGF-? therefore induces a polygenic response in Myc-driven lymphomas involving transcription of PUMA, which is necessary for the rapid induction of cell death. ..
  44. Chacón Fernández P, Säuberli K, Colzani M, Moreau T, Ghevaert C, Barde Y. Brain-derived Neurotrophic Factor in Megakaryocytes. J Biol Chem. 2016;291:9872-81 pubmed publisher
  45. White H, Gray D. Analysis of immunoglobulin (Ig) isotype diversity and IgM/D memory in the response to phenyl-oxazolone. J Exp Med. 2000;191:2209-20 pubmed
  46. Loh N, Nebenius Oosthuizen D, Blake D, Smith A, Davies K. Role of beta-dystrobrevin in nonmuscle dystrophin-associated protein complex-like complexes in kidney and liver. Mol Cell Biol. 2001;21:7442-8 pubmed
    ..beta-Dystrobrevin may therefore be an anchor or scaffold for Dp71 and syntrophin isoforms, as well as other associating proteins at the basal membranes of kidney and liver, but is not necessary for the normal function of these mice. ..
  47. Boyle J, Spreadborough A, Greaves M, Birch J, Varley J, Scott D. Delayed chromosome changes in gamma-irradiated normal and Li-Fraumeni fibroblasts. Radiat Res. 2002;157:158-65 pubmed
    ..Our findings raise questions about the validity of quantitative extrapolation of cytogenetic data from Trp53-defective mice to radiogenic cancer risk in humans...
  48. Dumaz N, Marais R. Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. J Biol Chem. 2003;278:29819-23 pubmed
    ..These studies suggest that Raf-1 and cAMP form a signaling complex in cells. Upon activation of PKA, Raf-1 is phosphorylated and 14-3-3 binds, blocking Raf-1 recruitment to the plasma membrane and preventing its activation. ..
  49. Brown J, Gilliland S, Spratt B, Holden D. A locus contained within a variable region of pneumococcal pathogenicity island 1 contributes to virulence in mice. Infect Immun. 2004;72:1587-93 pubmed
    ..Gene variation within horizontally acquired DNA such as that of PPI1 may be one factor modulating differences in virulence among strains...
  50. Browne G, Proud C. A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. Mol Cell Biol. 2004;24:2986-97 pubmed
    ..eEF2 kinase is thus a target for mTOR signaling independently of previously known downstream components of the pathway. ..
  51. Bancroft A, Humphreys N, Worthington J, Yoshida H, Grencis R. WSX-1: a key role in induction of chronic intestinal nematode infection. J Immunol. 2004;172:7635-41 pubmed
    ..These studies demonstrate an important role for WSX-1 signaling in the promotion of type 1 responses and chronic gastrointestinal nematode infection...
  52. Chen Y, Abraham D, Shi wen X, Pearson J, Black C, Lyons K, et al. CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell. 2004;15:5635-46 pubmed
    ..These results are consistent with the notion that a principal function of CCN2 is to modulate receptor/ligand interactions in vivo. ..
  53. Tam C, Husmann K, Clark N, Clark J, Lazar Z, Ittner L, et al. Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2. Circ Res. 2006;98:262-70 pubmed
    ..Thus RAMP2 plays a key role in the sensitivity and potency of AM-induced hypotensive responses via the AM1 receptor, providing evidence that this receptor is a selective target for novel therapeutic approaches. ..
  54. Lowell S, Benchoua A, Heavey B, Smith A. Notch promotes neural lineage entry by pluripotent embryonic stem cells. PLoS Biol. 2006;4:e121 pubmed
    ..Limiting activation of endogenous Notch results in heterogeneous lineage commitment. Manipulation of Notch signalling is therefore likely to be a key factor in taking command of ES cell lineage choice. ..
  55. Croft D, Olson M. The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms. Mol Cell Biol. 2006;26:4612-27 pubmed
    ..Therefore, the influence of ROCK on cell cycle regulatory proteins occurs by multiple independent mechanisms. ..
  56. Leese M, Leblond B, Smith A, Newman S, Di Fiore A, De Simone G, et al. 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem. 2006;49:7683-96 pubmed
    ..2-Substituted E2bisMATEs are attractive candidates for further development as multitargeted anticancer agents...
  57. Entrican G, Wattegedera S, Rocchi M, Wheelhouse N. Pregnancy, indoleamine 2,3-dioxygenase (IDO) and chlamydial abortion: an unresolved paradox. Vet Microbiol. 2009;135:98-102 pubmed publisher
    ..This paradox is discussed in the context of immune modulation during pregnancy, tryptophan biosynthesis by Chlamydiaceae and differences in placental structures between sheep, humans and mice. ..
  58. Holmes M, Carter R, Noble J, Chitnis S, Dutia A, Paterson J, et al. 11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments. J Neurosci. 2010;30:6916-20 pubmed publisher
    ..Thus, excess 11beta-HSD1 in forebrain is a cause of as well as a therapeutic target in memory impairments with aging. ..
  59. Parfitt D, Zernicka Goetz M. Epigenetic modification affecting expression of cell polarity and cell fate genes to regulate lineage specification in the early mouse embryo. Mol Biol Cell. 2010;21:2649-60 pubmed publisher
    ..These results demonstrate how the extent of a specific epigenetic modification could affect expression of cell polarity and fate-determining genes to ensure lineage allocation in the mouse embryo. ..
  60. Thakker R. Multiple endocrine neoplasia type 1 (MEN1). Best Pract Res Clin Endocrinol Metab. 2010;24:355-70 pubmed publisher
    ..The majority of MEN1 mutations are likely to disrupt the interactions of Menin with other proteins and thereby alter critical events in cell cycle regulation and proliferation...
  61. Al Sabbagh M, Fusi L, Higham J, Lee Y, Lei K, Hanyaloglu A, et al. NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling. Endocrinology. 2011;152:730-40 pubmed publisher
    ..Thus, NOX-4 activation and reactive oxygen species signaling play an integral role in initiating the endometrial decidual response in preparation of pregnancy...
  62. Xiao Q, Wang G, Yin X, Luo Z, Margariti A, Zeng L, et al. Chromobox protein homolog 3 is essential for stem cell differentiation to smooth muscles in vitro and in embryonic arteriogenesis. Arterioscler Thromb Vasc Biol. 2011;31:1842-52 pubmed publisher
    ..Our findings suggest that the interaction between Cbx3 and Dia-1/SRF is essential for SMC differentiation from stem cells and for the development of functional cardiovascular system. ..
  63. Selvadurai H, Mason J. Wnt/β-catenin signalling is active in a highly dynamic pattern during development of the mouse cerebellum. PLoS ONE. 2011;6:e23012 pubmed publisher
    ..These results indicate a variety of potential functions for Wnt/β-catenin activity during cerebellum development. ..
  64. Perona Wright G, Lundie R, Jenkins S, Webb L, Grencis R, MacDonald A. Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction. J Immunol. 2012;188:2350-8 pubmed publisher
  65. Bay V, Butt A. Relationship between glial potassium regulation and axon excitability: a role for glial Kir4.1 channels. Glia. 2012;60:651-60 pubmed publisher
    ..Glial Kir have increasing importance in K(+) clearance at higher levels of axonal activity, helping to maintain the physiological [K(+)](o) ceiling and ensure the fidelity of signaling between the retina and brain. ..
  66. West E, Gonzalez Cordero A, Hippert C, Osakada F, Martinez Barbera J, Pearson R, et al. Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem Cells. 2012;30:1424-35 pubmed publisher
    ..Despite showing expression profiles characteristic of immature photoreceptors, the ESC-derived precursors generated using this protocol did not display transplantation competence equivalent to precursors from the postnatal retina. ..
  67. Boonrungsiman S, Gentleman E, Carzaniga R, Evans N, McComb D, Porter A, et al. The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation. Proc Natl Acad Sci U S A. 2012;109:14170-5 pubmed publisher
    ..These observations may have important implications in deciphering both how normal bone forms and in understanding pathological mineralization. ..
  68. Lee C, Mudaliar M, Haggart D, Wolf C, Miele G, Vass J, et al. Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology. PLoS ONE. 2012;7:e48238 pubmed publisher
    ..Overall, the algorithm shows promise for early detection of toxicity in the drug discovery process. ..
  69. Galea G, Meakin L, Sugiyama T, Zebda N, Sunters A, Taipaleenmaki H, et al. Estrogen receptor ? mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor ?. J Biol Chem. 2013;288:9035-48 pubmed publisher
    ..ER-targeting therapy may facilitate structurally appropriate bone formation by enhancing the distinct ligand-independent, strain-related contributions to proliferation of both ER? and ER?. ..
  70. Hoerder Suabedissen A, Oeschger F, Krishnan M, Belgard T, Wang W, Lee S, et al. Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia. Proc Natl Acad Sci U S A. 2013;110:3555-60 pubmed publisher
    ..Our report emphasizes the importance of the study of transient features of the developing brain to better understand neurodevelopmental disorders. ..
  71. Roversi P, Ryffel B, Togbe D, Maillet I, Teixeira M, Ahmat N, et al. Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury. J Biol Chem. 2013;288:18789-802 pubmed publisher
    ..The findings suggest that dual inhibition of C5 and LTB4 may be useful for treatment of human immune complex-dependent diseases. ..
  72. Gwyer Findlay E, Danks L, Madden J, Cavanagh M, McNamee K, McCann F, et al. OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis. Proc Natl Acad Sci U S A. 2014;111:2289-94 pubmed publisher
    ..This work shows that more targeted approaches may augment the "therapeutic window" and increase the benefit/risk in RA, and possibly other autoimmune diseases, and are thus worth testing in humans. ..
  73. Forootan F, Forootan S, Gou X, Yang J, Liu B, Chen D, et al. Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter. Oncotarget. 2016;7:9322-39 pubmed publisher
  74. Harvey A, Montezano A, Hood K, Lopes R, Ríos F, Ceravolo G, et al. Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: The aldosterone-mineralocorticoid receptor-Nox1 axis. Life Sci. 2017;179:110-119 pubmed publisher
    ..Our findings suggest that aldosterone, which is increased in SHRSP, induces vascular damage through MR-Nox1-p66Shc-mediated processes that modulate pro-fibrotic and pro-inflammatory signaling pathways. ..
  75. Whiteland J, Nicholls S, Shimeld C, Easty D, Williams N, Hill T. Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. J Histochem Cytochem. 1995;43:313-20 pubmed
  76. Jones A, Korpi E, McKernan R, Pelz R, Nusser Z, Mäkelä R, et al. Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression. J Neurosci. 1997;17:1350-62 pubmed
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