Genomes and Genes
Experts and Doctors on mice in Sweden
Publications571 found, 100 shown here
- Svensson A, Casey P, Young S, Bergo M. Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. Methods Enzymol. 2006;407:144-59 pubmed
- Wootz H, Weber E, Korhonen L, Lindholm D. Altered distribution and levels of cathepsinD and cystatins in amyotrophic lateral sclerosis transgenic mice: possible roles in motor neuron survival. Neuroscience. 2006;143:419-30 pubmed..The observed changes in the levels and distributions of cathepsinD and cystatinB and-C indicate a role of these proteins in the degeneration of motor neurons in ALS. ..
- Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhäll C, et al. Functional relevance of the IL-23-IL-17 axis in lungs in vivo. Am J Respir Cell Mol Biol. 2007;36:442-51 pubmed..These findings support that IL-23 and IL-17 form a functionally relevant "immunological axis" in the lungs in vivo. ..
- Ekoff M, Strasser A, Nilsson G. FcepsilonRI aggregation promotes survival of connective tissue-like mast cells but not mucosal-like mast cells. J Immunol. 2007;178:4177-83 pubmed..These findings demonstrate a difference among mast cell populations in their ability to undergo activation-induced survival after FcepsilonRI stimulation, which might explain the slower turnover of CTMC in IgE-dependent reactions...
- Sharoyko V, Zaitseva I, Leibiger B, Efendic S, Berggren P, Zaitsev S. Arachidonic acid signaling is involved in the mechanism of imidazoline-induced KATP channel-independent stimulation of insulin secretion. Cell Mol Life Sci. 2007;64:2985-93 pubmed
- Jerlhag E, Egecioglu E, Dickson S, Svensson L, ENGEL J. Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors are involved in mediating the ghrelin-induced locomotor stimulation and dopamine overflow in nucleus accumbens. Eur Neuropsychopharmacol. 2008;18:508-18 pubmed publisher..We therefore suggest that the alpha(3)beta(2), beta(3) and/or alpha(6) subtypes might be pharmacological targets for treatment of addictive behaviours including compulsive overeating and alcoholism. ..
- Portela Gomes G, Gayen J, Grimelius L, Stridsberg M, Mahata S. The importance of chromogranin A in the development and function of endocrine pancreas. Regul Pept. 2008;151:19-25 pubmed publisher..Our study shows that CgA exerts a significant influence on the endocrine pancreas with importance in maintaining islet volume, cellular composition and function. ..
- Carlsson A, Ohsawa M, Hallberg M, Nyberg F, Kamei J. Substance P(1-7) induces antihyperalgesia in diabetic mice through a mechanism involving the naloxone-sensitive sigma receptors. Eur J Pharmacol. 2010;626:250-5 pubmed publisher..These results suggest that hyperalgesia in diabetic mice may be, in part, due to the enhanced endogenous sigma(1) receptor systems in the spinal cord. ..
- Johnsson A, Karlsson R. Microtubule-dependent localization of profilin I mRNA to actin polymerization sites in serum-stimulated cells. Eur J Cell Biol. 2010;89:394-401 pubmed publisher..Here we provide evidence for a microtubule-dependent localization of mRNA encoding the actin regulatory protein profilin to sites in mouse embryonic fibroblasts, which express enhanced actin polymerization. ..
- Andersson I, Batsalova T, Dzhambazov B, Edvinsson L, Holmdahl R, Kihlberg J, et al. Oxazole-modified glycopeptides that target arthritis-associated class II MHC A(q) and DR4 proteins. Org Biomol Chem. 2010;8:2931-40 pubmed publisher..This work contributes to the development of an altered glycopeptide for inducing immunological tolerance in CIA, with the long-term goal of developing a therapeutic vaccine for treatment of RA. ..
- Tobias J, Holmgren J, Hellman M, Nygren E, Lebens M, Svennerholm A. Over-expression of major colonization factors of enterotoxigenic Escherichia coli, alone or together, on non-toxigenic E. coli bacteria. Vaccine. 2010;28:6977-84 pubmed publisher..We conclude that the described type of recombinant bacteria over-expressing major CFs of ETEC, alone or in combination, may be useful as candidate strains for use in an oral whole-cell CF-ETEC vaccine...
- Yadav M, Zhang J, Fischer H, Huang W, Lutay N, Cirl C, et al. Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence. PLoS Pathog. 2010;6:e1001120 pubmed publisher..Dysregulation of the host response by microbial TcpC thus appears to impair the protective effects of innate immunity, while promoting inflammation and tissue damage. ..
- Ingberg E, Theodorsson A, Theodorsson E, Strom J. Methods for long-term 17?-estradiol administration to mice. Gen Comp Endocrinol. 2012;175:188-93 pubmed publisher..The peroral method and silastic capsules described in this article constitute reliable modes of administration of 17?-estradiol, superior to the widely used commercial pellets. ..
- Hagberg C, Mehlem A, Falkevall A, Muhl L, Fam B, Ortsäter H, et al. Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes. Nature. 2012;490:426-30 pubmed publisher..We propose VEGF-B antagonism as a novel pharmacological approach for type 2 diabetes, targeting the lipid-transport properties of the endothelium to improve muscle insulin sensitivity and glucose disposal. ..
- Rahman A, Ekman M, Shakirova Y, Andersson K, Morgelin M, Erjefalt J, et al. Late onset vascular dysfunction in the R6/1 model of Huntington's disease. Eur J Pharmacol. 2013;698:345-53 pubmed publisher..Our results reveal that arteries in the R6/1 model of Huntington's disease exhibit an age-dependent impairment of contractility and that they depend less on mitochondrial function when they contract. ..
- Wu C, Oberg D, Rashid A, Gupta R, Mignardi M, Johansson S, et al. A mouse mammary epithelial cell line permissive for highly efficient human adenovirus growth. Virology. 2013;435:363-71 pubmed publisher..NMuMG cells might therefore be useful in virotherapy research and the analysis of antiviral defense mechanisms and the determination of toxicity, biodistribution and specific antitumour activity of oncolytic HAdV vectors. ..
- Berglund D, Karlsson M, Palanisamy S, Carlsson B, Korsgren O, Eriksson O. Imaging the in vivo fate of human T cells following transplantation in immunoincompetent mice - implications for clinical cell therapy trials. Transpl Immunol. 2013;29:105-8 pubmed publisher..01) and spleen (p<0.05). This study presents a protocol for labeling of T cells by [(111)In]oxine with preserved viability and in vivo tracking by SPECT for up to 8days, which can easily be translated to clinical cell therapy trials. ..
- Gad H, Koolmeister T, Jemth A, Eshtad S, Jacques S, Ström C, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014;508:215-21 pubmed publisher..This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal. ..
- Geng Y, Almqvist M, Hansson G. cDNA cloning and expression of inducible nitric oxide synthase from rat vascular smooth muscle cells. Biochim Biophys Acta. 1994;1218:421-4 pubmed..This is supported by the short half-life (2.6 h) of smooth muscle NO synthase mRNA, which contrasts with brain and endothelial NO synthase. ..
- Olsson T, Bakhiet M, Hojeberg B, Ljungdahl A, Edlund C, Andersson G, et al. CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule. Cell. 1993;72:715-27 pubmed..The host-parasite interaction in experimental African trypanosomiasis thus involves parasite release of TLTF, which by binding to CD8 triggers CD8+ cells to produce the parasite growth-promoting cytokine IFN-gamma. ..
- Wang S, Zhou Y, Lukinius A, Oberg K, Skogseid B, Gobl A. Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3. Biochim Biophys Acta. 1998;1393:173-8 pubmed..The observation of PLC-beta3 nuclear localization suggests that PLC-beta3 may have intranuclear functions. ..
- Johansson A, Helou K, Levan G. Cytogenetic localization of cancer-related genes in the rat and comparative mapping studies in human and mouse. Cytogenet Cell Genet. 1998;81:217-21 pubmed..The remaining gene (Map1a) is involved in microtubule assembly. ..
- Liuba P, Karnani P, Pesonen E, Paakkari I, Forslid A, Johansson L, et al. Endothelial dysfunction after repeated Chlamydia pneumoniae infection in apolipoprotein E-knockout mice. Circulation. 2000;102:1039-44 pubmed..Cyclooxygenase-dependent vasoconstricting products may also account for the infection-induced impaired relaxation. These findings further support the role of C pneumoniae infection in atherosclerosis development. ..
- Ronne H, Lundgren S, Severinsson L, Rask L, Peterson P. Growth factor-binding proteases in the murine submaxillary gland: isolation of a cDNA clone. EMBO J. 1983;2:1561-4 pubmed
- Hakansson P, Andersson I, Nystrom S, Lofgren L, Amrot L, Li H. Ontogenetic development and spatial distribution of the ileal apical sodium-dependent bile acid transporter and the ileal lipid-binding protein in apoE knockout and C57BL/6 mice. Scand J Gastroenterol. 2002;37:1089-96 pubmed..The bile acid enterohepatic circulation in apoE-/- mice probably does not differ greatly from that in C57BL/6 mice. ..
- Phillipson M, Henriksnäs J, Holstad M, Sandler S, Holm L. Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice. Am J Physiol Gastrointest Liver Physiol. 2003;285:G154-62 pubmed..The results suggest that iNOS is constitutively expressed in the gastric mucosa and is involved in acid-induced hyperemia, suggesting a novel role for iNOS in gastric mucosal protection. ..
- Queva C, Bremner Danielsen M, Edlund A, Ekstrand A, Elg S, Erickson S, et al. Effects of GABA agonists on body temperature regulation in GABA(B(1))-/- mice. Br J Pharmacol. 2003;140:315-22 pubmed..Using this model, GHB was shown to be a selective GABAB receptor agonist. In addition, GABAB(1)-/- mice are hypersensitive to GABAA receptor stimulation, indicating that GABAB tone normally balances GABAA-mediated effects...
- Ilback N, Glynn A, Wikberg L, Netzel E, Lindh U. Metallothionein is induced and trace element balance changed in target organs of a common viral infection. Toxicology. 2004;199:241-50 pubmed..This may be a normal response in common infections that could adversely influence the pathogenesis when the host is concomitantly exposed to potentially toxic trace elements, even at levels in the physiological range. ..
- Lindås A, Tomkinson B. Identification and characterization of the promoter for the gene encoding human tripeptidyl-peptidase II. Gene. 2005;345:249-57 pubmed..The potential role of Sp1 in transcription of TPP2 therefore remains to be established. ..
- Andersson E, Jensen J, Parmar M, Guillemot F, Bjorklund A. Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2. Development. 2006;133:507-16 pubmed
- Spulber S, Oprica M, Bartfai T, Winblad B, Schultzberg M. Blunted neurogenesis and gliosis due to transgenic overexpression of human soluble IL-1ra in the mouse. Eur J Neurosci. 2008;27:549-58 pubmed publisher..Taken together, our results indicate that IL-1 is crucial for the adaptability of the brain to acute and chronic neuroinflammation. ..
- Sorrentino A, Thakur N, Grimsby S, Marcusson A, von Bulow V, Schuster N, et al. The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat Cell Biol. 2008;10:1199-207 pubmed publisher..Our data show that TGF-beta specifically activates TAK1 through interaction of TbetaRI with TRAF6, whereas activation of Smad2 is not dependent on TRAF6. ..
- Wang X, Carlsson Y, Basso E, Zhu C, Rousset C, Rasola A, et al. Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury. J Neurosci. 2009;29:2588-96 pubmed publisher..The role of CypD in HI shifts from a predominantly prosurvival protein in the immature to a cell death mediator in the adult brain. ..
- MÃ¼ller F, Mutch N, Schenk W, Smith S, Esterl L, Spronk H, et al. Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell. 2009;139:1143-56 pubmed publisher..The data identify polyP as a new class of mediator having fundamental roles in platelet-driven proinflammatory and procoagulant disorders. ..
- Westergren R, Nilsson D, Heglind M, Arani Z, Grände M, Cederberg A, et al. Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo. Am J Physiol Endocrinol Metab. 2010;298:E548-54 pubmed publisher..Foxf2 and its downstream target genes can provide new insights with regard to identification of novel therapeutic targets. ..
- Dougherty K, Kiehn O. Firing and cellular properties of V2a interneurons in the rodent spinal cord. J Neurosci. 2010;30:24-37 pubmed publisher..These data are compatible with V2a neurons having a role in regulating segmental left-right alternation and ipsilateral motor neuron firing with little effect on rhythm generation. ..
- Zhou A, Hartwig J, Akyürek L. Filamins in cell signaling, transcription and organ development. Trends Cell Biol. 2010;20:113-23 pubmed publisher..This review focuses on the emerging roles of filamins in cell signaling and transcription, with emphasis on cell motility and organ development. ..
- Hühn M, McCartney S, Lind K, Svedin E, Colonna M, Flodstrom Tullberg M. Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after Coxsackievirus infection. Virology. 2010;401:42-8 pubmed publisher..Taken together, our findings indicate that MDA-5 plays an important role in the host immune response to CVB3 by preventing early virus replication and limiting tissue pathology. ..
- Petersson J, Schreiber O, Hansson G, Gendler S, Velcich A, Lundberg J, et al. Importance and regulation of the colonic mucus barrier in a mouse model of colitis. Am J Physiol Gastrointest Liver Physiol. 2011;300:G327-33 pubmed publisher..Furthermore, the ability of bacteria to regulate the thickness of the colonic mucus was demonstrated. ..
- Wick M. Innate immune control of Salmonella enterica serovar Typhimurium: mechanisms contributing to combating systemic Salmonella infection. J Innate Immun. 2011;3:543-9 pubmed publisher..Finally, the mechanisms driving recruitment of myeloid cells to infected intestinal lymphoid tissues and what is known about Toll-like receptor signaling pathways in innate immunity to Salmonella infection is also discussed. ..
- Astrom Olsson K, Li L, Olofsson C, Boren J, Ohlin H, Grip L. Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium dynamics. Biochem Biophys Res Commun. 2012;422:732-8 pubmed publisher..6, why this model may be suitable for further studies on ischemia and reperfusion with respect to calcium handling of the sarcoplasmic reticulum. ..
- Andersson D, Wilhelmsson U, Nilsson M, Kubista M, Ståhlberg A, Pekna M, et al. Plasticity response in the contralesional hemisphere after subtle neurotrauma: gene expression profiling after partial deafferentation of the hippocampus. PLoS ONE. 2013;8:e70699 pubmed publisher..We conclude that even a very limited focal neurotrauma triggers a distinct response at the contralesional side, which at least to some extent depends on astrocyte activation. ..
- Pan N, Bai Y, Yang Y, Hokfelt T, Xu Z. Activation of galanin receptor 2 stimulates large conductance Ca(2+)-dependent K(+) (BK) channels through the IP3 pathway in human embryonic kidney (HEK293) cells. Biochem Biophys Res Commun. 2014;446:316-21 pubmed publisher..Taken together, activation of GalR2 leads to elevation of intracellular Ca(2+) is due to Ca(2+) efflux from ER through IP3R sequentially opening BK channels. ..
- Sundelin J, Provvedini D, Wahlestedt C, Laurell H, Pohl J, Peterson P. Molecular cloning of the murine substance K and substance P receptor genes. Eur J Biochem. 1992;203:625-31 pubmed..The cloning of the murine substance K and substance P receptor genes should contribute substantially to the generation of in vivo models for the detailed analysis of the functional significance of these receptors. ..
- Molin G, Soderlind O, Ursing J, Nørrung V, Ternström A, Löwenhielm C. Occurrence of Erysipelothrix rhusiopathiae on pork and in pig slurry, and the distribution of specific antibodies in abattoir workers. J Appl Bacteriol. 1989;67:347-52 pubmed..In 20 of 138 workers antibodies against E. rhusiopathiae were found; 14 had increased levels of IgG antibodies, seven had increased levels of IgM antibodies and one had an increased level of both...
- Coumailleau P, Poellinger L, Gustafsson J, Whitelaw M. Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity. J Biol Chem. 1995;270:25291-300 pubmed
- Klinga Levan K, Andersson A, Hanson C, Ridderström M, Stenberg G, Mannervik B, et al. Mapping of glutathione transferase (GST) genes in the rat. Hereditas. 1993;119:285-96 pubmed..Interestingly, each of the three groups of conserved synteny seems to span the region across the centromeres of the human chromosomes. ..
- Grawe J, Nusse M, Adler I. Quantitative and qualitative studies of micronucleus induction in mouse erythrocytes using flow cytometry. I. Measurement of micronucleus induction in peripheral blood polychromatic erythrocytes by chemicals with known and suspected genotoxicity. Mutagenesis. 1997;12:1-8 pubmed..The method also allows a substantial reduction in the number of animals needed. ..
- Tiger C, Gullberg D. Abscence of laminin alpha1 chain in the skeletal muscle of dystrophic dy/dy mice. Muscle Nerve. 1997;20:1515-24 pubmed..Our data might be important when designing therapy strategies for CMD. ..
- Esni F, Taljedal I, Perl A, Cremer H, Christofori G, Semb H. Neural cell adhesion molecule (N-CAM) is required for cell type segregation and normal ultrastructure in pancreatic islets. J Cell Biol. 1999;144:325-37 pubmed..Possible mechanisms underlying this phenomenon may include changes in cadherin-mediated adhesion and cell polarity. ..
- Fundin B, Mikaels A, Westphal H, Ernfors P. A rapid and dynamic regulation of GDNF-family ligands and receptors correlate with the developmental dependency of cutaneous sensory innervation. Development. 1999;126:2597-610 pubmed
- Svensson C, Silverstone A, Lai Z, Lundberg K. Dioxin-induced adseverin expression in the mouse thymus is strictly regulated and dependent on the aryl hydrocarbon receptor. Biochem Biophys Res Commun. 2002;291:1194-200 pubmed..This further supports that adseverin induction is a specific gene regulatory effect by TCDD on thymocytes. ..
- Thonberg H, Fredriksson J, Nedergaard J, Cannon B. A novel pathway for adrenergic stimulation of cAMP-response-element-binding protein (CREB) phosphorylation: mediation via alpha1-adrenoceptors and protein kinase C activation. Biochem J. 2002;364:73-9 pubmed
- Xia G, Chen J, Tiwari V, Ju W, Li J, Malmstrom A, et al. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. J Biol Chem. 2002;277:37912-9 pubmed..These results provide a new insight regarding the mechanism for the biosynthesis of biologically active HS. ..
- Harandi A, Eriksson K, Holmgren J. A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. J Virol. 2003;77:953-62 pubmed
- Finnberg N, Stenius U, Hogberg J. Heterozygous p53-deficient (+/-) mice develop fewer p53-negative preneoplastic focal liver lesions in response to treatment with diethylnitrosamine than do wild-type (+/+) mice. Cancer Lett. 2004;207:149-55 pubmed..Furthermore, our findings suggest that the presence of only one functional p53 allele in p53+/- mice is sufficient to counteract the growth advantage that such an attenuated p53 response appears to confer. ..
- Halldner L, Aden U, Dahlberg V, Johansson B, Ledent C, Fredholm B. The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: a study in mice lacking adenosine A1 and/or A2A receptors. Neuropharmacology. 2004;46:1008-17 pubmed..Furthermore, these results suggest that the inhibitory effect of high doses of caffeine is due neither to blockade of the A1R, nor of the A2AR, and an effect independent of these adenosine receptors is likely. ..
- Takahashi Y, Li L, Kamiryo M, Asteriou T, Moustakas A, Yamashita H, et al. Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner. J Biol Chem. 2005;280:24195-204 pubmed..Our data show that hyaluronan fragments and FGF-2 affect endothelial cell morphogenesis by the induction of overlapping but also by distinct sets of genes. ..
- Håkansson P, Hofer A, Thelander L. Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells. J Biol Chem. 2006;281:7834-41 pubmed
- Chromek M, Slamová Z, Bergman P, Kovacs L, Podracká L, Ehren I, et al. The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat Med. 2006;12:636-41 pubmed..In addition, clinical E. coli strains that were more resistant to LL-37 caused more severe urinary tract infections than did susceptible strains. Thus, cathelicidin seems to be a key factor in mucosal immunity of the urinary tract. ..
- Song T, Mika F, Lindmark B, Liu Z, Schild S, Bishop A, et al. A new Vibrio cholerae sRNA modulates colonization and affects release of outer membrane vesicles. Mol Microbiol. 2008;70:100-11 pubmed publisher..VrrA overproduction caused a distinct reduction in the TcpA protein level. Our findings suggest that VrrA contributes to bacterial fitness in certain stressful environments, and modulates infection of the host intestinal tract. ..
- Reigstad C, Lundén G, Felin J, Backhed F. Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota. PLoS ONE. 2009;4:e5842 pubmed publisher..6+/-0.1-fold, respectively). Our data suggest that LPS, and potentially other products of the indigenous gut microbiota, might elevate cytokine expression in tissues and thus exacerbate chronic low-grade inflammation observed in obesity. ..
- Forsberg G, Skartved N, Wallén Ohman M, Nyhlén H, Behm K, Hedlund G, et al. Naptumomab estafenatox, an engineered antibody-superantigen fusion protein with low toxicity and reduced antigenicity. J Immunother. 2010;33:492-9 pubmed publisher..Thus, naptumomab estafenatox is a novel optimized tumor-targeted superantigen currently investigated in clinical trials. ..
- Flach C, Ostberg A, Nilsson A, Malefyt R, Raghavan S. Proinflammatory cytokine gene expression in the stomach correlates with vaccine-induced protection against Helicobacter pylori infection in mice: an important role for interleukin-17 during the effector phase. Infect Immun. 2011;79:879-86 pubmed publisher..pylori infection, our study indicates that mainly T(h)17 effector mechanisms are of critical importance to protection. ..
- Reinbothe T, Mollet I. Optogenetic Control of Pancreatic Islets. Methods Mol Biol. 2016;1408:107-23 pubmed publisher..The technique is easy to set up and provides a useful tool for controlling the activity of distinct islet cell populations. ..
- Hörnquist C, Ekman L, Grdic K, Schon K, Lycke N. Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation. J Immunol. 1995;155:2877-87 pubmed..Thus, paradoxically, although IgA B cell differentiation appears to proceed normally in CD4-/- mice, specific gut mucosal immune responses are grossly impaired in the absence of CD4+ T cells. ..
- Palmqvist P, Lundberg P, Persson E, Johansson A, Lundgren I, Lie A, et al. Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway. J Biol Chem. 2006;281:2414-29 pubmed..The data indicate that IL-4 and IL-13, via a STAT6-dependent pathway, inhibit osteoclast differentiation and bone resorption by activating receptors on osteoblasts and osteoclasts that affect the RANKL/RANK/OPG system. ..
- Bjursell M, Gerdin A, Ploj K, Svensson D, Svensson L, Oscarsson J, et al. Melanin-concentrating hormone receptor 1 deficiency increases insulin sensitivity in obese leptin-deficient mice without affecting body weight. Diabetes. 2006;55:725-33 pubmed..In conclusion, MCHr1 is important for insulin sensitivity and/or secretion via a mechanism not dependent on decreased body weight. ..
- Hägerkvist R, Sandler S, Mokhtari D, Welsh N. Amelioration of diabetes by imatinib mesylate (Gleevec): role of beta-cell NF-kappaB activation and anti-apoptotic preconditioning. FASEB J. 2007;21:618-28 pubmed..We conclude that imatinib mediates beta-cell survival and that this could contribute to the beneficial effects observed in diabetes. ..
- Pedersen M, Ronnstrand L, Sun J. The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit. Cell Signal. 2009;21:413-8 pubmed publisher..Taken together, these findings reveal that the differences in downstream signal transduction and biological responses between the two GNNK isoforms are eliminated by the D816V mutant. ..
- Spalding K, Bergmann O, Alkass K, Bernard S, Salehpour M, Huttner H, et al. Dynamics of hippocampal neurogenesis in adult humans. Cell. 2013;153:1219-1227 pubmed publisher..We conclude that neurons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neurogenesis may contribute to human brain function. ..
- Papareddy P, Kalle M, Singh S, Morgelin M, Schmidtchen A, Malmsten M. An antimicrobial helix A-derived peptide of heparin cofactor II blocks endotoxin responses in vivo. Biochim Biophys Acta. 2014;1838:1225-34 pubmed publisher..Together, these findings suggest that GKS26 may be of interest for further investigations as therapeutic against severe infections and septic shock. ..
- Schou M, Varnas K, Jureus A, Ahlgren C, Malmquist J, Häggkvist J, et al. Discovery and Preclinical Validation of [(11)C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor. ACS Chem Neurosci. 2016;7:177-84 pubmed publisher..11)C]5 has suitable properties for quantification of H3 receptors in nonhuman primate brain and has the potential to offer improved binding kinetics in man compared to [(11)C]1. ..
- Bednar I, Paterson D, Marutle A, Pham T, Svedberg M, Hellström Lindahl E, et al. Selective nicotinic receptor consequences in APP(SWE) transgenic mice. Mol Cell Neurosci. 2002;20:354-65 pubmed..The upregulation of the nAChRs probably reflects compensatory mechanisms in response to Abeta burden in the brains of Tg+ mice. ..
- Andersson P, McGuire J, Rubio C, Gradin K, Whitelaw M, Pettersson S, et al. A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proc Natl Acad Sci U S A. 2002;99:9990-5 pubmed
- Karlstrom H, Beatus P, Dannaeus K, Chapman G, Lendahl U, Lundkvist J. A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling. Proc Natl Acad Sci U S A. 2002;99:17119-24 pubmed..Taken together, these data suggest that trafficking and localization rather than signaling of mNotch 3 are affected in mNotch 3(R142C). ..
- Löfgren M, Ekblad E, Morano I, Arner A. Nonmuscle Myosin motor of smooth muscle. J Gen Physiol. 2003;121:301-10 pubmed..High ADP binding and low phosphate dependence of nonmuscle myosin would influence both velocity of actin translocation and force generation to promote slow motility and economical force maintenance of the cell. ..
- Gunhaga L, Marklund M, Sjödal M, Hsieh J, Jessell T, Edlund T. Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nat Neurosci. 2003;6:701-7 pubmed..Here we show in chick embryos that sequential Wnt and fibroblast growth factor (FGF) signaling specifies cells of dorsal telencephalic character. ..
- Gawlik K, Miyagoe Suzuki Y, Ekblom P, Takeda S, Durbeej M. Laminin alpha1 chain reduces muscular dystrophy in laminin alpha2 chain deficient mice. Hum Mol Genet. 2004;13:1775-84 pubmed..Correction of LNalpha2 chain deficiency by LNalpha1 chain may serve as a paradigm for gene therapy of CMD in patients. ..
- Ekstedt E, Holm L, Ridderstråle Y. Carbonic anhydrase in mouse testis and epididymis; transfer of isozyme IV to spermatozoa during passage. J Mol Histol. 2004;35:167-73 pubmed..The significance of CA for pH-regulating processes vital for sperm storage and motility is discussed. A function in HCO3- transport during sperm capacitation at fertilization is suggested for the CA IV found in spermatozoa. ..
- Brånén L, Hovgaard L, Nitulescu M, Bengtsson E, Nilsson J, Jovinge S. Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol. 2004;24:2137-42 pubmed..Accordingly, TNF-alpha represents a possible target for prevention of atherosclerosis. This may be of particular importance in rheumatoid arthritis because these patients have an increased risk for cardiovascular disease. ..
- Kuznetsov N, Andersson P, Gradin K, Stein P, Dieckmann A, Pettersson S, et al. The dioxin/aryl hydrocarbon receptor mediates downregulation of osteopontin gene expression in a mouse model of gastric tumourigenesis. Oncogene. 2005;24:3216-22 pubmed
- Nowak G, Ericzon B, Nava S, Jaksch M, Westgren M, Sumitran Holgersson S. Identification of expandable human hepatic progenitors which differentiate into mature hepatic cells in vivo. Gut. 2005;54:972-9 pubmed..Successful in vitro expansion of liver progenitor cells provides a basis for developing cell therapy strategies, metabolic and toxicity testing systems, and may serve as a vehicle for gene therapy. ..
- Bergsland M, Werme M, Malewicz M, Perlmann T, Muhr J. The establishment of neuronal properties is controlled by Sox4 and Sox11. Genes Dev. 2006;20:3475-86 pubmed..Together, these findings demonstrate a central regulatory role of Sox4 and Sox11 during neuronal maturation and mechanistically separate cell cycle withdrawal from the establishment of neuronal properties. ..
- Bryja V, Andersson E, Schambony A, Esner M, Bryjova L, Biris K, et al. The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol Biol Cell. 2009;20:924-36 pubmed publisher..Thus, we provide evidence that the extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt signaling during Xenopus and mouse development in vivo. ..
- Hogmalm A, Sheppard D, Lappalainen U, Bry K. beta6 Integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia. Am J Respir Cell Mol Biol. 2010;43:88-98 pubmed publisher..We conclude that absence of the beta6 integrin subunit protects the infant murine lung against IL-1beta-induced inflammation and injury. ..
- Yasmin L, Veesenmeyer J, Diaz M, Francis M, Ottmann C, Palmer R, et al. Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins. Biochem J. 2010;427:217-24 pubmed publisher..Thus the interaction between the 'roof' of the groove of 14-3-3 and ExoS relies more on hydrophobic interaction forces, which probably contributes to induce cell death after ExoS infection and activation...
- Porritt M, Andersson H, Hou L, Nilsson A, Pekna M, Pekny M, et al. Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane. PLoS ONE. 2012;7:e41090 pubmed publisher..The results show that sulforaphane treatment initiated after photothrombosis-induced permanent cerebral ischemia does not interfere with key cellular mechanisms underlying tissue damage...
- Navabi N, Johansson M, Raghavan S, Linden S. Helicobacter pylori infection impairs the mucin production rate and turnover in the murine gastric mucosa. Infect Immun. 2013;81:829-37 pubmed publisher..pylori creates a more stable and favorable environment for itself by impairing the defense mechanism for clearing the mucosal surface of pathogens by mucus flow...