Experts and Doctors on mice in Poland


Locale: Poland
Topic: mice

Top Publications

  1. Goł b J, Zagozdzon R, Kaminski R, Kozar K, Gryska K, Izycki D, et al. Potentiatied antitumor effectiveness of combined chemo-immunotherapy with interleukin-12 and 5-fluorouracil of L1210 leukemia in vivo. Leukemia. 2001;15:613-20 pubmed
  2. Krzyzowska M, Schollenberger A, Skierski J, Niemialtowski M. Apoptosis during ectromelia orthopoxvirus infection is DEVDase dependent: in vitro and in vivo studies. Microbes Infect. 2002;4:599-611 pubmed
    ..i. was caspase independent. Therefore, we conclude that DEVDase- (caspase-3- and caspase-7-) dependent apoptosis is an important mechanism regulating the resolution of EV infection...
  3. Czuczwar M, Kis J, Czuczwar P, Wielosz M, Turski W. Nicotine diminishes anticonvulsant activity of antiepileptic drugs in mice. Pol J Pharmacol. 2003;55:799-802 pubmed
    ..The obtained data may suggest that interaction between nicotine and antiepileptic drugs should be carefully considered as a cause of the therapeutic failure in epileptic patients. ..
  4. Zalewska Kaszubska J, Czarnecka E. Deficit in beta-endorphin peptide and tendency to alcohol abuse. Peptides. 2005;26:701-5 pubmed
    ..Its release increases significantly after alcohol consumption. Clinical and laboratory studies confirm that certain genetically determined factors might increase the individual's vulnerability to alcohol abuse. ..
  5. Bryniarski K, Szczepanik M, Ptak M, Ptak W. Modulation of testicular macrophage activity by collagenase. Folia Histochem Cytobiol. 2005;43:37-41 pubmed
    ..We conclude that in the case of local inflammation in the testis, ROI-negative TMs do not contribute to the tissue damage and instead may direct the local immune response into humoral pathway. ..
  6. Korostynski M, Kaminska Chowaniec D, Piechota M, Przewlocki R. Gene expression profiling in the striatum of inbred mouse strains with distinct opioid-related phenotypes. BMC Genomics. 2006;7:146 pubmed
    ..The genes identified in this work constitute promising candidates for further animal studies and for translational genetic studies in the field of addictive and analgesic properties of opioids. ..
  7. Skuza G, Rogóz Z. Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice. Pharmacol Rep. 2009;61:1179-83 pubmed
    ..These results support the idea that sigma(1)-receptors, but not sigma(2)-receptors, contribute to the mechanism of antidepressant activity of sigma agonists in FST. ..
  8. Łukawski K, Swiderska G, Łuszczki J, Czuczwar S. Influence of ethacrynic acid on the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock seizure model. Pharmacol Rep. 2010;62:808-13 pubmed
    ..Taking into consideration the clinical use of both drugs, this interaction between EA and VPA can be important for patients receiving these drugs. ..
  9. Lukaszuk B, Bialuk I, Gorski J, Zajączkiewicz M, Winnicka M, Chabowski A. A single bout of exercise increases the expression of glucose but not fatty acid transporters in skeletal muscle of IL-6 KO mice. Lipids. 2012;47:763-72 pubmed publisher
    ..We may speculate, that IL-6 deficiency provokes more pronounced glucose utilization over lipid oxidation during a single bout of exhausting exercise. ..

More Information

Publications252 found, 100 shown here

  1. Gesing A, Masternak M, Lewinski A, Karbownik Lewinska M, Kopchick J, Bartke A. Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice. J Gerontol A Biol Sci Med Sci. 2013;68:639-51 pubmed publisher
    ..This may attribute the primary role to GH resistance in the regulation of apoptosis and mitochondrial biogenesis in GHRKO mice in terms of increased life span. ..
  2. Milczarek M, Psurski M, Kutner A, Wietrzyk J. Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivo mouse colon cancer model. BMC Cancer. 2013;13:294 pubmed publisher
    ..The activity of PRI-2191 is realized through stopping the cells in the G?/G? cell cycle phase and increasing the expression of E-cadherin. ..
  3. Canale V, Kurczab R, Partyka A, Satała G, Lenda T, Jastrzębska Więsek M, et al. Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties. Eur J Med Chem. 2016;108:334-346 pubmed publisher
    ..Finally, the study provided valuable insight into the development of potential therapeutic agents for the treatment of CNS disorders. ..
  4. Ziółkowska B, Korostyński M, Piechota M, Kubik J, Przewłocki R. Effects of morphine on immediate-early gene expression in the striatum of C57BL/6J and DBA/2J mice. Pharmacol Rep. 2012;64:1091-104 pubmed
    ..They also suggest inter-strain differences in the development of striatal neuroadaptations to chronic morphine treatment. ..
  5. Toka F, Niemiałtowski M, Spohr de Faundez I, Gierynska M. Cytotoxic T lymphocyte control during ectromelia (mousepox) virus infection: interaction between MHC-restricted cells analyzed by non-radioactive fluorometry. Acta Virol. 1996;40:239-44 pubmed
    ..Also an alternative method for determining CMC, employing a bisbenzamide dye for labelling target cells, is described. Coefficient variations of relative fluorescence were below 6%, that makes the method sensitive and reliable...
  6. Majsterek I, Blasiak J, Mlynarski W, Hoser G, Skorski T. Does the bcr/abl-mediated increase in the efficacy of DNA repair play a role in the drug resistance of cancer cells?. Cell Biol Int. 2002;26:363-70 pubmed
    ..We hypothesize that this observed increase in the efficacy of repair in BCR/ABL- positive cells is involved in their resistance to idarubicin. ..
  7. Mazur L, Augustynek A, Halicka H, Deptała A. Induction of apoptosis in bone marrow cells after treatment of mice with WR-2721 and gamma-rays: relationship to the cell cycle. Cell Biol Toxicol. 2003;19:13-27 pubmed
    ..A modulatory, suppressive action of WR-2721 on apoptosis induction and the cell cycle perturbation caused in normal cells of the mouse bone marrow by gamma-rays was found. ..
  8. Lukasiewicz J, Jachymek W, Niedziela T, Dzieciatkowska M, Lakomska J, Miedzybrodzki R, et al. Serological characterization of anti-endotoxin serum directed against the conjugate of oligosaccharide core of Escherichia coli type R4 with tetanus toxoid. FEMS Immunol Med Microbiol. 2003;37:59-67 pubmed
    ..The serum inhibited endotoxin-induced tumor necrosis factor alpha and nitric oxide synthesis by the J-774A.1 cell line and attenuated pulmonary retention of YAC-1 cells. ..
  9. Bryniarski K, Maresz K, Szczepanik M, Ptak M, Ptak W. Modulation of macrophage activity by proteolytic enzymes. Differential regulation of IL-6 and reactive oxygen intermediates (ROIs) synthesis as a possible homeostatic mechanism in the control of inflammation. Inflammation. 2003;27:333-40 pubmed
  10. Chodaczek G, Zimecki M, Lukasiewicz J, Lugowski C. A complex of lactoferrin with monophosphoryl lipid A is an efficient adjuvant of the humoral and cellular immune response in mice. Med Microbiol Immunol. 2006;195:207-16 pubmed
    ..Its activity surpassed the adjuvant action of both constituents tested separately in the humoral and cellular immune responses in mice. The plausible mode of action of the new adjuvant is discussed. ..
  11. Dabrowska K, Zembala M, Boratynski J, Switala Jelen K, Wietrzyk J, Opolski A, et al. Hoc protein regulates the biological effects of T4 phage in mammals. Arch Microbiol. 2007;187:489-98 pubmed publisher
    ..Although HAP1 was previously defined to bind cancer cells more effectively (than T4), its rapid elimination precluded its higher concentration in tumours...
  12. Iciek M, Marcinek J, Mleczko U, Włodek L. Selective effects of diallyl disulfide, a sulfane sulfur precursor, in the liver and Ehrlich ascites tumor cells. Eur J Pharmacol. 2007;569:1-7 pubmed
    ..These data indicate that this compound is capable of acting efficiently and selectively only in the liver and can be used for hepatoprotection during chemotherapy. ..
  13. Dabrowska K, Skaradziński G, Jończyk P, Kurzepa A, Wietrzyk J, Owczarek B, et al. The effect of bacteriophages T4 and HAP1 on in vitro melanoma migration. BMC Microbiol. 2009;9:13 pubmed publisher
    ..We also believe that they will contribute to the general understanding of bacteriophage biology, as bacteriophages, extremely ubiquitous entities, are in permanent contact with human organisms. ..
  14. Frackowiak A, Skibiński P, Gaweł W, Zaczynska E, Czarny A, Gancarz R. Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compounds in kidney stone therapy. Eur J Med Chem. 2010;45:1001-7 pubmed publisher
    ..In addition, the effect of the compounds obtained on real kidney stones was analyzed by ex vivo tests. The tests on L929 and A545 cell lines have shown that the compounds obtained were not cytotoxic...
  15. Hus I, Kawiak J, Hoser G, Tabarkiewicz J, Radej S, Dmoszynska A, et al. SCID mice model in vivo evaluation of autologous and allogeneic dendritic cells activity on B-cell chronic lymphocytic leukemia. Folia Histochem Cytobiol. 2009;47:563-70 pubmed publisher
    ..We found, that mean numbers of CD19+CD5+ leukemic cells as well as human T cells were lowered in peritoneal fluid of mice treated with allogeneic APCs. However, we did not observe similar effects with autologous DCs. ..
  16. Biała G, Budzyńska B. Rimonabant attenuates sensitization, cross-sensitization and cross-reinstatement of place preference induced by nicotine and ethanol. Pharmacol Rep. 2010;62:797-807 pubmed
  17. Grygoruk C, Pietrewicz P, Modlinski J, Gajda B, Greda P, Grad I, et al. Influence of embryo transfer on embryo preimplantation development. Fertil Steril. 2012;97:1417-21 pubmed publisher
    ..To investigate the impact of injection speeds of the transferred load on embryo development...
  18. Nasulewicz Goldeman A, Uszczyńska B, Szczaurska Nowak K, Wietrzyk J. siRNA-mediated silencing of integrin ?3 expression inhibits the metastatic potential of B16 melanoma cells. Oncol Rep. 2012;28:1567-73 pubmed publisher
    ..These results provide evidence for a direct role of integrin ?3 in the adhesion, migration and metastasis processes of mouse melanoma cells and point to the potential therapeutic advantages of siRNAs. ..
  19. Olejnik A, Kowalska K, Kidoń M, Czapski J, Rychlik J, Olkowicz M, et al. Purple carrot anthocyanins suppress lipopolysaccharide-induced inflammation in the co-culture of intestinal Caco-2 and macrophage RAW264.7 cells. Food Funct. 2016;7:557-64 pubmed publisher
    ..These findings may provide preliminary justification for the use of PCA in further studies focused on the prevention and therapy supporting the conventional treatment of inflammatory bowel diseases. ..
  20. Górska S, Buda B, Brzozowska E, Schwarzer M, Srůtková D, Kozakova H, et al. Identification of Lactobacillus proteins with different recognition patterns between immune rabbit sera and nonimmune mice or human sera. BMC Microbiol. 2016;16:17 pubmed publisher
    ..The identification of immunoreactive lactobacilli proteins opens the possibility to use them as an antigens for development of vaccines. ..
  21. Gu S, Kumar M, Sikorska B, Hejduk J, Markowski J, Markowski M, et al. Isolation and partial characterization of a highly divergent lineage of hantavirus from the European mole (Talpa europaea). Sci Rep. 2016;6:21119 pubmed publisher
    ..Neuropathological examination showed astrocytic and microglial activation and neuronal loss. The first mole-borne hantavirus isolate will facilitate long-overdue studies on its infectivity and pathogenic potential in humans. ..
  22. Prendecka M, Mlak R, Jaszek M, Osińska Jaroszuk M, Jakubiak Hulicz M, Leibold C, et al. Effect of exopolysaccharide from Ganoderma applanatum on the electrical properties of mouse fibroblast cells line L929 culture using an electric cell-substrate impedance sensing (ECIS) - Preliminary study. Ann Agric Environ Med. 2016;23:280-4 pubmed publisher
    ..In the future, following further studies (comprising in preventive and therapeutic actions), GpEPS can be safely used in anti-cancer therapy which does not cause side-effects or damage to healthy cells. ..
  23. Luszczki J, Czuczwar P, Cioczek Czuczwar A, Czuczwar S. Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model. Eur J Pharmacol. 2006;547:65-74 pubmed
    ..To elucidate the protective role of cannabinoids in the brain during seizures, more advanced neurochemical studies are required. ..
  24. Arkusz J, Stepnik M, Lewińska D, Stańczyk M, Palus J, Dziubałtowska E. Interleukin-1beta expression in murine J774A.1 macrophages exposed to platinum compounds: the role of p38 and ERK 1/2 mitogen-activated protein kinases. Toxicol In Vitro. 2007;21:371-9 pubmed
    ..These data suggest that p38 MAPK and ERK 1/2 play an important role in induction of IL-1beta expression in J774A.1 macrophages exposed to test platinum compounds...
  25. Wesołowska A, Tatarczyńska E, Nikiforuk A, Chojnacka Wójcik E. Enhancement of the anti-immobility action of antidepressants by a selective 5-HT7 receptor antagonist in the forced swimming test in mice. Eur J Pharmacol. 2007;555:43-7 pubmed
    ..The obtained results indicate that blockade of 5-HT7 receptors may facilitate the anti-immobility effect of antidepressants in mice. ..
  26. Luszczki J, Antkiewicz Michaluk L, Raszewski G, Czuczwar S. Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis. Epilepsy Res. 2010;89:207-19 pubmed publisher
    ..The combinations of MeTHIQ with LTG, OXC and PGB were neutral in the mouse MES model. ..
  27. Łuszczki J, Jaskólska A, Dworzański W, Zółkowska D. 7-Nitroindazole, but not NG-nitro-L-arginine, enhances the anticonvulsant activity of pregabalin in the mouse maximal electroshock-induced seizure model. Pharmacol Rep. 2011;63:169-75 pubmed
    ..Based on this preclinical study, one can conclude that 7NI significantly enhanced and NNA had no effect on the anticonvulsant activity of PGB against MES-induced seizures in mice. ..
  28. Maciejewska Z, Pascal A, Kubiak J, Ciemerych M. Phosphorylated ERK5/BMK1 transiently accumulates within division spindles in mouse oocytes and preimplantation embryos. Folia Histochem Cytobiol. 2011;49:528-34 pubmed
    ..In telophase oocytes it becomes incorporated into the midbody. Dynamic changes in the localization of phospho-ERK5 suggests that it may play an important role both in meiotic and mitotic division. ..
  29. Grodecka M, Wasniowska K, Halverson G, Yazdanbakhsh K, Reid M, Lisowska E. The production, serologic evaluation, and epitope mapping of ten murine monoclonal Dombrock antibodies. Immunohematology. 2012;28:124-9 pubmed
    ..The dependence of some epitopes on antigen glycosylation is also a possibility. ..
  30. Lazniewska J, Janaszewska A, Miłowska K, Caminade A, Mignani S, Katir N, et al. Promising low-toxicity of viologen-phosphorus dendrimers against embryonic mouse hippocampal cells. Molecules. 2013;18:12222-40 pubmed publisher
    ..Summarising, low-cytotoxicity on mHippoE-18 cells together with their ability to quench ROS, make the VPDs very promising nanodevices for future applications in the biomedical field as nanocarriers and/or drugs per se. ..
  31. Kassassir H, Siewiera K, Sychowski R, Watała C. Can the antiplatelet effects of cangrelor be reliably studied in mice under in vivo and in vitro conditions using flow cytometry?. Pharmacol Rep. 2013;65:870-83 pubmed
  32. Milczarek J, Pawlowska R, Zurawiński R, Lukasik B, Garner L, Chworos A. Fluorescence and confocal imaging of mammalian cells using conjugated oligoelectrolytes with phenylenevinylene core. J Photochem Photobiol B. 2017;170:40-48 pubmed publisher
  33. Gatkowska J, Hiszczynska Sawicka E, Kur J, Holec L, Dlugonska H. Toxoplasma gondii: an evaluation of diagnostic value of recombinant antigens in a murine model. Exp Parasitol. 2006;114:220-7 pubmed
    ..Our results show that the recombinant antigens are useful in distinguishing between acute and chronic toxoplasmosis regardless of the genetically determined susceptibility of the host. ..
  34. Wronska Nofer T, Wisniewska Knypl J, Wyszynska K, Dziubałtowska E. Genotoxicity of industrial dyes under the inductive effect of ethanol on monooxygenase system in mice. Mutat Res. 1997;392:229-35 pubmed
  35. Metodiewa D, Kochman A, Skolimowski J, Koceva Chyła A. TTT, a novel free radical spin trap, induces apoptosis in sarcoma Yoshida cells in vivo: comparative investigations of its cytotoxicity in vitro. Anticancer Res. 1999;19:3343-8 pubmed
    ..We found that TTT inhibits the growth and proliferation of two immortalized cell types-hamster B14 cell line and mouse NIH 3T3 fibroblasts which we used as a model for neoplastic phenotype, in a dose-dependent manner. ..
  36. Zagozdzon R, Giermasz A, Gołąb J, Stokłosa T, Jalili A, Jakobisiak M. The potentiated antileukemic effects of doxorubicin and interleukin-12 combination are not dependent on nitric oxide production. Cancer Lett. 1999;147:67-75 pubmed
    ..Therefore, further studies on the possible mechanisms of potentiated antileukemic activity of combination of IL-12 and DOX would be worth pursuing. ..
  37. Szutowicz A, Madziar B, Pawełczyk T, Tomaszewicz M, Bielarczyk H. Effects of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells. J Neurochem. 2004;90:952-61 pubmed
  38. Kowalski J, Samojedny A, Paul M, Pietsz G, Wilczok T. Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages. Pharmacol Rep. 2005;57:390-4 pubmed
    ..2 macrophages at the transcriptional level. In addition, the studied compounds may be the mediators responsible for protective role of a diet high in fruits and vegetables in the cardiovascular and inflammatory diseases. ..
  39. Basta Kaim A, Budziszewska B, Jaworska Feil L, Tetich M, Kubera M, Leskiewicz M, et al. Inhibitory effect of imipramine on the human corticotropin-releasing-hormone gene promoter activity operates through a PI3-K/AKT mediated pathway. Neuropharmacology. 2005;49:156-64 pubmed
    ..These results indicate that the inhibitory effect of imipramine on the CRH gene promoter activity in Neuro-2A cells is mainly connected with enhancement of PI-3K/Akt pathway. ..
  40. Sinski E, Bajer A, Welc R, Pawełczyk A, Ogrzewalska M, Behnke J. Babesia microti: prevalence in wild rodents and Ixodes ricinus ticks from the Mazury Lakes District of North-Eastern Poland. Int J Med Microbiol. 2006;296 Suppl 40:137-43 pubmed
    ..microti commonly encountered among Microtus spp. rodents is probably not a zoonotic strain and, therefore, that it is most unlikely to represent a risk to public health in the Mazury Lakes District of North-Eastern Poland...
  41. Galus R, Włodarski P, Włodarski K. Influence of fluvastatin on bone formation induced by demineralized bone matrix in mice. Pharmacol Rep. 2006;58:443-7 pubmed
  42. Pajtasz Piasecka E, Rossowska J, Dus D, Weber Dabrowska B, Zabłocka A, Gorski A. Bacteriophages support anti-tumor response initiated by DC-based vaccine against murine transplantable colon carcinoma. Immunol Lett. 2008;116:24-32 pubmed publisher
    ..Therefore, pretreatment of DCs with the phages may be considered as a beneficial element of a novel strategy in anti-tumor immunotherapy. ..
  43. Mycko M, Cwiklinska H, Walczak A, Libert C, Raine C, Selmaj K. A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigen. Eur J Immunol. 2008;38:1999-2013 pubmed publisher
  44. Niewiarowska J, Sacewicz I, Wiktorska M, Wysocki T, Stasikowska O, Wagrowska Danilewicz M, et al. DNAzymes to mouse beta1 integrin mRNA in vivo: targeting the tumor vasculature and retarding cancer growth. Cancer Gene Ther. 2009;16:713-22 pubmed publisher
    ..1 and PC-3 cells within the 3 weeks of experiment duration. Thus, DNAzymes targeting beta1 integrin genes can inhibit multiple key tumorigenic processes in vitro and in vivo and may serve as useful anti-cancer agents. ..
  45. Chabowski A, Zmijewska M, Gorski J, Bonen A, Kaminski K, Kozuch M, et al. IL-6 deficiency increases fatty acid transporters and intramuscular lipid content in red but not white skeletal muscle. J Physiol Pharmacol. 2008;59 Suppl 7:105-17 pubmed
    ..IL-6 ablation increases fatty acid transporter expression and intramuscular lipid accumulation, particularly the saturated fatty acids. These effects however were confined to oxidative muscles, as glycolytic muscles were not affected. ..
  46. Razny U, Kiec Wilk B, Wator L, Polus A, Dyduch G, Solnica B, et al. Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance. Cardiovasc Diabetol. 2011;10:68 pubmed publisher
    ..Our results indicate that increased NO availability attenuates some HFD induced alterations in metabolism and gene expression associated with insulin resistance. ..
  47. Baranowski M, Gorski J. Heart sphingolipids in health and disease. Adv Exp Med Biol. 2011;721:41-56 pubmed publisher
    ..In the last section of this chapter we discuss the evidence for a role of ceramide in myocardial lipotoxicity. ..
  48. Młyniec K, Davies C, Budziszewska B, Opoka W, Reczyński W, Sowa Kućma M, et al. Time course of zinc deprivation-induced alterations of mice behavior in the forced swim test. Pharmacol Rep. 2012;64:567-75 pubmed
    ..The obtained results indicate that zinc deprivation induced "pro-depressive" behavior (after the initial period of "antidepressive" behavior). This pro-depressive behavior correlates with enhanced serum corticosterone concentration. ..
  49. Majewska Szczepanik M, Góralska M, Marcińska K, Zemelka Wiącek M, Strzępa A, Dorożyńska I, et al. Epicutaneous immunization with protein antigen TNP-Ig alleviates TNBS-induced colitis in mice. Pharmacol Rep. 2012;64:1497-504 pubmed
    ..This work shows that EC immunization with protein antigen prior to TNBS-colitis induction ameliorates disease and observed suppression of inflammatory response in the colon might be mediated by IL-10. ..
  50. Rogóż Z. Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice. Pharmacol Rep. 2012;64:1567-72 pubmed
    ..Further studies are necessary to elucidate its mechanism of action. ..
  51. Mycko M, Sliwinska B, Cichalewska M, Cwiklinska H, Raine C, Selmaj K. Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination. J Neurosci. 2014;34:8646-58 pubmed publisher
    ..Thus, we have defined a novel mechanism of negative regulation of T cell function by endogenous brain-derived glycolipids, a family of molecules traditionally deemphasized in favor of myelin proteins in studies of CNS autoimmunity. ..
  52. Bil Lula I, Krzywonos Zawadzka A, Sawicki G, Woźniak M. An infection of human adenovirus 31 affects the differentiation of preadipocytes into fat cells, its metabolic profile and fat accumulation. J Med Virol. 2016;88:400-7 pubmed publisher
    ..The results obtained from this study provided the evidences that HAdV31, likewise previously documented HAdV36, is a subsequent human adenovirus affecting the differentiation and lipid accumulation of 3T3L1 cells. ..
  53. Bober J, Olsnes S, Kostas M, Bogacz M, Zakrzewska M, Otlewski J. Identification of new FGF1 binding partners-Implications for its intracellular function. IUBMB Life. 2016;68:242-51 pubmed publisher
    ..Thus, our study indicates that the role of intracellular FGF1 is to protect the cell against stress conditions by providing an additional signal for cell survival, independently of receptor-activated signaling cascades. ..
  54. Obniska J, Rapacz A, Rybka S, Góra M, Kamiński K, Sałat K, et al. Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3-methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acids. Bioorg Med Chem. 2016;24:1598-607 pubmed publisher
    ..Several molecules showed antinociceptive and local anesthetic properties. The in vitro radioligand binding studies demonstrated that the influence on the sodium and calcium channels may be one of the essential mechanisms of action. ..
  55. Kruszewski M, Iwaneńko T. Labile iron pool correlates with iron content in the nucleus and the formation of oxidative DNA damage in mouse lymphoma L5178Y cell lines. Acta Biochim Pol. 2003;50:211-5 pubmed
    ..The critical factor appears to be the availability of transition metal ions that take part in the OH radical-generating Fenton reaction (very likely in the form of LIP)...
  56. Dzitko K, Staczek P, Gatkowska J, Dlugonska H. Toxoplasma gondii: Serological recognition of reinfection. Exp Parasitol. 2006;112:134-7 pubmed
    ..In our opinion ELISA combined with immunoblot could enable the recognition of reinfection cases in humans, but earlier our experimental data should be verified in clinical laboratory. ..
  57. Szijártó V, Guachalla L, Hartl K, Varga C, Banerjee P, Stojkovic K, et al. Both clades of the epidemic KPC-producing Klebsiella pneumoniae clone ST258 share a modified galactan O-antigen type. Int J Med Microbiol. 2016;306:89-98 pubmed publisher
    ..Based on these data, the galactan-III antigen may represent an attractive target for active and passive immunization approaches against K. pneumoniae ST258. ..
  58. Cybulska B, Seksek O, Henry Toulme N, Czerwinski A, Bolard J. Polyene macrolide antibiotics: indirect stimulation of the Na+/H+ exchanger of BALB/c B lymphoid cell line, A20. Biochem Pharmacol. 1992;44:539-45 pubmed
    ..The non-aromatic polyene antibiotic amphotericin B had a low ability to increase proton permeability. ..
  59. Rode W, Dabrowska M, Zielinski Z, Gołos B, Wranicz M, Felczak K, et al. Trichinella spiralis and Trichinella pseudospiralis: developmental patterns of enzymes involved in thymidylate biosynthesis and pyrimidine salvage. Parasitology. 2000;120 ( Pt 6):593-600 pubmed
    ..A hypothesis is discussed, assuming high expression of thymidylate synthase in muscle larvae to be connected with their cells being arrested in the cell cycle. ..
  60. Kruszewski M, Zastawny T, Szumiel I. Repair of gamma-ray-induced base damage in L5178Y sublines is damage type-dependent and unrelated to radiation sensitivity. Acta Biochim Pol. 2001;48:525-33 pubmed
  61. Ziolkowski P, Osiecka B, Oremek G, Siewinski M, Symonowicz K, Saleh Y, et al. Enhancement of photodynamic therapy by use of aminolevulinic acid/glycolic acid drug mixture. J Exp Ther Oncol. 2004;4:121-9 pubmed
    ..01). These results provide evidence that addition of glycolic acid should be considered as the agent which enhances 5-ALA penetration in tissues and thus increases the effectiveness of photodynamic therapy. ..
  62. Mezyk Kopec R, Bzowska M, Potempa J, Bzowska M, Jura N, Sroka A, et al. Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis. Infect Immun. 2005;73:1506-14 pubmed
    ..Thus, gingipains are able not only to cleave soluble TNF-alpha but also to destroy the membrane form of the cytokine, which may additionally dysregulate the cytokine network. ..
  63. Nowakowska D, Respondek Liberska M, Golab E, Stray Pedersen B, Szaflik K, Dzbenski T, et al. Too late prenatal diagnosis of fetal toxoplasmosis: a case report. Fetal Diagn Ther. 2005;20:190-3 pubmed
    ..Congenital toxoplasmosis was confirmed by the detection of anti- T. gondii IgM and IgA in the neonatal serum. The presented case is an example of severe fetal toxoplasmosis diagnosed and treated in utero. ..
  64. Luszczki J, Ratnaraj N, Patsalos P, Czuczwar S. Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. Epilepsy Behav. 2005;7:639-51 pubmed
    ..75-0.91) used in this study. However, these conclusions are confounded by the fact that LCZ is associated with significant pharmacokinetic interactions. ..
  65. Stasik I, Rapak A, Kalas W, Ziolo E, Strzadala L. Ionomycin-induced apoptosis of thymocytes is independent of Nur77 NBRE or NurRE binding, but is accompanied by Nur77 mitochondrial targeting. Biochim Biophys Acta. 2007;1773:1483-90 pubmed
    ..This indicates that thymocytes can undergo apoptosis through the intrinsic Nur77-mediated mitochondrial pathway and that the transactivation activity of Nur77 monomers or dimers is not necessary for thymocyte apoptosis. ..
  66. Domin H, Przykaza Å, Jantas D, Koźniewska E, Boguszewski P, ÅšmiaÅ‚owska M. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016;102:276-94 pubmed publisher
    ..In conclusion, our results indicate that ACPT-I may be not only neuroprotective against ischemic neuronal damage but may also diminish the postischemic functional deficits. ..
  67. Zagozdzon R, Gołąb J, Stokłosa T, Giermasz A, Nowicka D, Feleszko W, et al. Effective chemo-immunotherapy of L1210 leukemia in vivo using interleukin-12 combined with doxorubicin but not with cyclophosphamide, paclitaxel or cisplatin. Int J Cancer. 1998;77:720-7 pubmed
    ..Our observations demonstrating potentiation of the antileukemic effects of the IL-12 and doxorubicin combination suggest that the combined use of these 2 agents could be beneficial in leukemia therapy. ..
  68. Dastych J, Taub D, Hardison M, Metcalfe D. Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis. Am J Physiol. 1998;275:C1291-9 pubmed
    ..These observations are consistent with the conclusions that Wv c-kit initiates a signaling process that is PI 3-kinase dependent and that mutated Wv c-kit retains the ability to initiate mast cell adhesion and migration. ..
  69. Mazur L. Radioprotective effects of the thiols GSH and WR-2721 against X-ray-induction of micronuclei in erythroblasts. Mutat Res. 2000;468:27-33 pubmed
    ..The effective radioprotection by the combined action of GSH and WR-2721 against genomic instability induced in the mouse erythroblasts by X-rays was shown. ..
  70. Karasek M, Carrillo Vico A, Guerrero J, Winczyk K, Pawlikowski M. Expression of melatonin MT(1) and MT(2) receptors, and ROR alpha(1) receptor in transplantable murine Colon 38 cancer. Neuro Endocrinol Lett. 2002;23 Suppl 1:55-60 pubmed
    ..Our studies on Colon 38 adenocarcinoma cells support the concept that both membrane and nuclear receptors are involved in the oncostatic action of melatonin. ..
  71. Artym J, Zimecki M, Paprocka M, Kruzel M. Orally administered lactoferrin restores humoral immune response in immunocompromised mice. Immunol Lett. 2003;89:9-15 pubmed
  72. Arkusz J, Stańczyk M, Lewińiska D, Stepnik M. Modulation of murine peritoneal macrophage function by chronic exposure to arsenate in drinking water. Immunopharmacol Immunotoxicol. 2005;27:315-30 pubmed
    ..The potential consequences of decreased production of NO and superoxide by peritoneal macrophages as observed in exposed mice may suggest impaired response of the cells against infection or developing tumor cells. ..
  73. Biała G, Budzynska B, Kruk M. Naloxone precipitates nicotine abstinence syndrome and attenuates nicotine-induced antinociception in mice. Pharmacol Rep. 2005;57:755-60 pubmed
    ..These data support the hypothesis that similar opioid-cholinergic interactions are involved in nicotine-induced antinociception and nicotine withdrawal syndrome. ..
  74. Zimecki M, Artym J, Kocieba M. Endogenous steroids are responsible for lactoferrin-induced myelopoiesis in mice. Pharmacol Rep. 2009;61:705-10 pubmed
    ..We conclude that LF-induced upregulation of endogenous steroid levels is responsible for the stimulation of myelopoiesis. ..
  75. Galus R, Niderla J, Sladowski D, Sajjad E, Włodarski K, Jóźwiak J. Fluvastatin increases tyrosinase synthesis induced by alpha-melanocyte-stimulating hormone in B16F10 melanoma cells. Pharmacol Rep. 2010;62:164-9 pubmed
    ..These findings indicate that fluvastatin increases tyrosinase synthesis induced by alpha-melanocyte-stimulating hormone in B16F10 cells and reveal an unknown effect of statin use: their influence on melanin production. ..
  76. Łuszczki J. Dose-response relationship analysis of pregabalin doses and their antinociceptive effects in hot-plate test in mice. Pharmacol Rep. 2010;62:942-8 pubmed
    ..33, 24.80, 65.93, and 175.26 mg/kg, respectively. In conclusion, pregabalin produces analgesic effects in a dose-dependent manner, as demonstrated using the hot-plate test in mice. ..
  77. Mysliwiec J, Zbucki R, Nikolajuk A, Mysliwiec P, Kaminski K, Bondyra Z, et al. Estrogens modulate RANKL-RANK/osteoprotegerin mediated interleukin-6 effect on thyrotoxicosis-related bone turnover in mice. Horm Metab Res. 2011;43:236-40 pubmed publisher
  78. Wróbel M. Acquisition and expression of ethanol-induced conditioned place preference in mice is inhibited by naloxone. Pharmacol Rep. 2011;63:79-85 pubmed
  79. Talarek S, Listos J, Fidecka S. Effect of nitric oxide synthase inhibitors on benzodiazepine withdrawal in mice and rats. Pharmacol Rep. 2011;63:680-9 pubmed
    ..Moreover, a clear propensity of L-NOARG to protect benzodiazepine-dependent rats against audiogenic seizures was observed. These findings suggest that the cGMP/NO system may participate in causing the signs of benzodiazepine withdrawal. ..
  80. Rogóż Z, Kabziński M. Enhancement of the anti-immobility action of antidepressants by risperidone in the forced swimming test in mice. Pharmacol Rep. 2011;63:1533-8 pubmed
    ..The obtained results indicate that a low dose of risperidone enhances the activity of ADs in an animal model of depression, and that, among other mechanisms, 5-HT(1A) receptors may play a role in these effects. ..
  81. Kłossowicz M, Scirka B, Suchanek J, Marek Bukowiec K, Kisielow P, Aguado E, et al. Assessment of caspase mediated degradation of linker for activation of T cells (LAT) at a single cell level. J Immunol Methods. 2013;389:9-17 pubmed publisher
    ..This finding can be used as an additional marker for T regulatory cell lineage. ..
  82. Kalas W, Swiderek E, Switalska M, Wietrzyk J, Rak J, Strzadala L. Thrombospondin-1 receptor mediates autophagy of RAS-expressing cancer cells and triggers tumour growth inhibition. Anticancer Res. 2013;33:1429-38 pubmed
    ..This is consistent with near complete loss of TSP-1 expression in RAS-transformed cells and may open new avenues for therapies involving TSP-1 peptides, in a subset of tumours. ..
  83. Wolak M, Siwek A, Szewczyk B, Poleszak E, Pilc A, Popik P, et al. Involvement of NMDA and AMPA receptors in the antidepressant-like activity of antidepressant drugs in the forced swim test. Pharmacol Rep. 2013;65:991-7 pubmed
  84. Łukawski K, Jakubus T, Janowska A, Raszewski G, Czuczwar S. Enalapril enhances the anticonvulsant activity of lamotrigine in the test of maximal electroshock. Pharmacol Rep. 2013;65:1012-7 pubmed
    ..Enalapril even enhanced the anticonvulsant activity of LTG in the MES test in mice that is thought to be a predictive model of human generalized tonic-clonic seizures. ..
  85. Salaga M, Storr M, Martemyanov K, Fichna J. RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives. Bioessays. 2016;38:344-54 pubmed publisher
    ..The ideas introduced in this review set a novel conceptual framework for the utilization of RGS proteins in the treatment of gastrointestinal inflammation, a growing major concern worldwide. ..
  86. Lachowicz J, Nurchi V, Crisponi G, Jaraquemada Pelaez M, Arca M, Pintus A, et al. Hydroxypyridinones with enhanced iron chelating properties. Synthesis, characterization and in vivo tests of 5-hydroxy-2-(hydroxymethyl)pyridine-4(1H)-one. Dalton Trans. 2016;45:6517-28 pubmed publisher
    ..The chelating ability of P1 toward these ions, not higher than that of the corresponding deferiprone, contributes to render P1 a more selective iron chelator. ..
  87. Mikulska J, Pablo L, Canel J, Simister N. Cloning and analysis of the gene encoding the human neonatal Fc receptor. Eur J Immunogenet. 2000;27:231-40 pubmed
    ..Primer extension analysis showed that there are two transcription initiation sites in the upstream flanking sequence. ..
  88. Łuszczki J, Kocharov S, Czuczwar S. Effect of p-isopropoxyphenylsuccinimide monohydrate on the anticonvulsant action of carbamazepine, phenobarbital, phenytoin and valproate in the mouse maximal electroshock-induced seizure model. Pharmacol Rep. 2010;62:194-202 pubmed
    ..The combinations of IPPS with carbamazepine and phenobarbital are neutral from a preclinical viewpoint. ..
  89. Kalaska B, Sokolowska E, Kaminski K, Szczubialka K, Kramkowski K, Mogielnicki A, et al. Cationic derivative of dextran reverses anticoagulant activity of unfractionated heparin in animal models of arterial and venous thrombosis. Eur J Pharmacol. 2012;686:81-9 pubmed publisher
    ..Further clinical studies are needed to estimate whether modified dextran could replace protamine sulfate, especially in dialyzed patients with the end-stage renal disease associated with anemia. ..
  90. Wielgat P, Holownia A, Braszko J. Lipopolysaccharide changes sialylation pattern in the mouse central nervous system. J Physiol Pharmacol. 2012;63:555-61 pubmed
    ..Given the significance of glycans in the brain biology we can conclude that sialic acids and their receptors Siglec may be crucial regulators of immune response in the CNS. ..
  91. Piliszek A, Madeja Z, Plusa B. Suppression of ERK signalling abolishes primitive endoderm formation but does not promote pluripotency in rabbit embryo. Development. 2017;144:3719-3730 pubmed publisher
    ..Furthermore, our results provide insight into the observed discrepancies relating to the role of FGF/ERK signalling in PrE versus EPI specification between mouse and other mammals. ..
  92. Lukasiewicz J, Niedziela T, Jachymek W, Kenne L, Lugowski C. Structure of the lipid A-inner core region and biological activity of Plesiomonas shigelloides O54 (strain CNCTC 113/92) lipopolysaccharide. Glycobiology. 2006;16:538-50 pubmed
    ..shigelloides O54 LPS, resolving the entire molecule. Biological activities and observed discrepancy between in vitro and in vivo activity of P. shigelloides and Escherichia coli LPS are discussed...