Experts and Doctors on mice in Israel


Locale: Israel
Topic: mice

Top Publications

  1. Priel E, Aflalo E, Chechelnitsky G, Benharroch D, Aboud M, Segal S. Inhibition of retrovirus-induced disease in mice by camptothecin. J Virol. 1993;67:3624-9 pubmed
    ..This ability of CPT to inhibit retrovirus-induced disease in vivo without causing any apparent toxic side effects suggests its application as a legitimate remedy for the treatment of retroviral diseases. ..
  2. Bar Peled O, Korkotian E, Segal M, Groner Y. Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons. Proc Natl Acad Sci U S A. 1996;93:8530-5 pubmed
    ..The data are compatible with the thesis that overexpression of Cu/Zn SOD creates chronic oxidative stress in the transgenic neurons, which exacerbates their susceptibility to additional insults such as KA-mediated excitotoxicity. ..
  3. Selvaraj N, Israeli D, Amsterdam A. Partial sequencing of the rat steroidogenic acute regulatory protein message from immortalized granulosa cells: regulation by gonadotropins and isoproterenol. Mol Cell Endocrinol. 1996;123:171-7 pubmed
    ..In addition, we find that the rat StAR cDNA exhibit a high degree of homology with the mouse and human sequences. ..
  4. Lallemand Y, Luria V, Haffner Krausz R, Lonai P. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase. Transgenic Res. 1998;7:105-12 pubmed
  5. Bank I, Weiss P, Doolman R, Book M, Sela B. Detection of soluble alpha1 integrin in human serum. J Lab Clin Med. 1999;134:599-604 pubmed
    ..These results suggest, for the first time, that salpha1 are present in healthy and diseased human serum. ..
  6. Henis Korenblit S, Strumpf N, Goldstaub D, Kimchi A. A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation. Mol Cell Biol. 2000;20:496-506 pubmed
  7. Wang X, Michael D, de Murcia G, Oren M. p53 Activation by nitric oxide involves down-regulation of Mdm2. J Biol Chem. 2002;277:15697-702 pubmed
    ..The drop in endogenous Mdm2 levels following NO treatment is accompanied by a corresponding reduction in the rate of p53 ubiquitination. Thus, the down-regulation of Mdm2 by NO is likely to contribute to the activation of p53. ..
  8. Petit I, Szyper Kravitz M, Nagler A, Lahav M, Peled A, Habler L, et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol. 2002;3:687-94 pubmed
    ..We suggest that manipulation of SDF-1 CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation. ..
  9. Bar Yehuda S, Madi L, Barak D, Mittelman M, Ardon E, Ochaion A, et al. Agonists to the A3 adenosine receptor induce G-CSF production via NF-kappaB activation: a new class of myeloprotective agents. Exp Hematol. 2002;30:1390-8 pubmed
    ..CF101 induced upregulation of the PI3K/NF-kappaB pathway leading to G-CSF production, resulting in myeloprotective effect in cyclophosphamide-treated mice. ..

More Information

Publications641 found, 100 shown here

  1. Schechter I, Ziv E. Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s). Biol Chem. 2008;389:313-20 pubmed publisher
    ..Nevertheless, as both BACE 1 and cathepsin D show poor activity towards the WT beta-site sequence, it is necessary to continue the search for additional beta-secretase candidate(s). ..
  2. Tzuman Y, Sapoznik S, Granot D, Nevo N, Neeman M. Peritoneal adhesion and angiogenesis in ovarian carcinoma are inversely regulated by hyaluronan: the role of gonadotropins. Neoplasia. 2010;12:51-60 pubmed
    ..Accordingly, angiogenesis of the adhered spheroids was significantly elevated in DON-treated tumors. These results can explain the selective pressure that can lead to simultaneously increased tumor expression of both HASs and Hyals...
  3. Kuperman Y, Issler O, Regev L, Musseri I, Navon I, Neufeld Cohen A, et al. Perifornical Urocortin-3 mediates the link between stress-induced anxiety and energy homeostasis. Proc Natl Acad Sci U S A. 2010;107:8393-8 pubmed publisher
  4. Elyakim E, Sitbon E, Faerman A, Tabak S, Montia E, Belanis L, et al. hsa-miR-191 is a candidate oncogene target for hepatocellular carcinoma therapy. Cancer Res. 2010;70:8077-87 pubmed publisher
    ..Our findings offer a preclinical proof of concept for miR-191 targeting as a rational strategy to pursue for improving HCC treatment. ..
  5. Nemirovsky A, Fisher Y, Baron R, Cohen I, Monsonego A. Amyloid beta-HSP60 peptide conjugate vaccine treats a mouse model of Alzheimer's disease. Vaccine. 2011;29:4043-50 pubmed publisher
  6. Sherman H, Genzer Y, Cohen R, Chapnik N, Madar Z, Froy O. Timed high-fat diet resets circadian metabolism and prevents obesity. FASEB J. 2012;26:3493-502 pubmed publisher
    ..Taken together, our findings suggest that timing can prevent obesity and rectify the harmful effects of a HF diet. ..
  7. Pomerantz Y, Elbaz J, Ben Eliezer I, Reizel Y, David Y, Galiani D, et al. From ubiquitin-proteasomal degradation to CDK1 inactivation: requirements for the first polar body extrusion in mouse oocytes. FASEB J. 2012;26:4495-505 pubmed publisher
    ..This information significantly contributes to our understanding of faulty chromosome segregation that may lead to aneuploidy. ..
  8. Schmidt R, Frydman L. In vivo 3D spatial/1D spectral imaging by spatiotemporal encoding: a new single-shot experimental and processing approach. Magn Reson Med. 2013;70:382-91 pubmed publisher
    ..In vivo results of fat and water separation on abdominal imaging of mice at 7 T and on human breast imaging at 3 T are presented. ..
  9. Achiron A, Mashiach R, Zilkha Falb R, Meijler M, Gurevich M. Polymerase I pathway inhibitor ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol. 2013;263:91-7 pubmed publisher
    ..Our findings demonstrate that POL1 pathway inhibition delayed and suppressed the development of EAE and ameliorated the disease in mice with persistent clinical signs. ..
  10. Glat M, Benninger F, Barhum Y, Ben Zur T, Kogan E, Steiner I, et al. Ectopic Muscle Expression of Neurotrophic Factors Improves Recovery After Nerve Injury. J Mol Neurosci. 2016;58:39-45 pubmed publisher
    ..Our findings suggest a rationale for using genetic treatment with a combination of NTF-expressing vectors, as a potential therapeutic approach for severe peripheral nerve injury. ..
  11. Krauskopf A, Resnekov O, Aloni Y. A cis downstream element participates in regulation of in vitro transcription initiation from the P38 promoter of minute virus of mice. J Virol. 1990;64:354-60 pubmed
    ..The correlation between the binding and transcription activation is discussed...
  12. Shulman L, Manor Y, Handsher R, Delpeyroux F, McDonough M, Halmut T, et al. Molecular and antigenic characterization of a highly evolved derivative of the type 2 oral poliovaccine strain isolated from sewage in Israel. J Clin Microbiol. 2000;38:3729-34 pubmed
  13. Eilam R, Peter Y, Groner Y, Segal M. Late degeneration of nigro-striatal neurons in ATM-/- mice. Neuroscience. 2003;121:83-98 pubmed
    ..Thus, the Atm-/- mouse may model the extrapyramidal motor deficits seen in AT patients. ..
  14. Kipnis J, Cardon M, Avidan H, Lewitus G, Mordechay S, Rolls A, et al. Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration. J Neurosci. 2004;24:6133-43 pubmed
    ..g., in neuronal degeneration) or for strengthening it (in autoimmune diseases). ..
  15. Breuer O, Lawhorn C, Miller T, Smith D, Brown L. Functional architecture of the mammalian striatum: mouse vascular and striosome organization and their anatomic relationships. Neurosci Lett. 2005;385:198-203 pubmed
    ..In addition, the greater vascularity of the striosomes compared to the matrix suggests a unique function of this compartment in relation to humoral signals and neurotropic drugs. ..
  16. Arzoine L, Zilberberg N, Ben Romano R, Shoshan Barmatz V. Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity. J Biol Chem. 2009;284:3946-55 pubmed publisher
    ..Moreover, VDAC1-based peptides interfering with HK-mediated anti-apoptotic activity may potentiate the efficacy of conventional chemotherapeutic agents. ..
  17. Zion O, Genin O, Kawada N, Yoshizato K, Roffe S, Nagler A, et al. Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention. Pancreas. 2009;38:427-35 pubmed publisher
    ..Halofuginone increased the synthesis of PAP-1, which further reduces pancreas fibrosis. Thus, halofuginone might serve as a novel therapy for pancreas fibrosis. ..
  18. Levanon D, Groner Y. Runx3-deficient mouse strains circa 2008: resemblance and dissimilarity. Blood Cells Mol Dis. 2009;43:1-5 pubmed publisher
    ..Here we summarize the phenotypic similarities and dissimilarities between two of the Runx3-deficient mouse strains, discuss the basis of the discrepancies and highlight the crux of the dispute. ..
  19. Pietr M, Kozela E, Levy R, Rimmerman N, Lin Y, Stella N, et al. Differential changes in GPR55 during microglial cell activation. FEBS Lett. 2009;583:2071-6 pubmed publisher
  20. Mor A, Kloog Y, Keren G, George J. Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice. Eur J Pharmacol. 2009;616:301-5 pubmed publisher
    ..Ras inhibition might therefore be worth developing as a new treatment modality in patients with type 1 diabetes...
  21. Gilsohn E, Volk T. Slowdown promotes muscle integrity by modulating integrin-mediated adhesion at the myotendinous junction. Development. 2010;137:785-94 pubmed publisher
    ..Our analysis implicates Slow as an essential component of the MTJ, crucial for ensuring muscle and tendon integrity during larval locomotion. ..
  22. Orenbuch A, Ayelet O, Shulman Y, Yoav S, Lipstein N, Noa L, et al. Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin. J Neurochem. 2012;120:248-58 pubmed publisher
    ..Our results therefore reveal hitherto unidentified feedback within the synaptic vesicle cycle involving the synapsin-managed reserve pool...
  23. Gal Mor O, Suez J, Elhadad D, Porwollik S, Leshem E, Valinsky L, et al. Molecular and cellular characterization of a Salmonella enterica serovar Paratyphi a outbreak strain and the human immune response to infection. Clin Vaccine Immunol. 2012;19:146-56 pubmed publisher
    ..This apparent profile implies a distinct immune response to paratyphoid infections. ..
  24. Dominissini D, Moshitch Moshkovitz S, Salmon Divon M, Amariglio N, Rechavi G. Transcriptome-wide mapping of N(6)-methyladenosine by m(6)A-seq based on immunocapturing and massively parallel sequencing. Nat Protoc. 2013;8:176-89 pubmed publisher
    ..The protocol can be completed within ~9 d for four different sample pairs (each consists of an immunoprecipitation and corresponding input). ..
  25. Vitner E, Salomon R, Farfel Becker T, Meshcheriakova A, Ali M, Klein A, et al. RIPK3 as a potential therapeutic target for Gaucher's disease. Nat Med. 2014;20:204-8 pubmed publisher
    ..Notably, Ripk3 deficiency substantially improved the clinical course of GD mice, with increased survival and motor coordination and salutary effects on cerebral as well as hepatic injury. ..
  26. Wlodarska M, Thaiss C, Nowarski R, Henao Mejia J, Zhang J, Brown E, et al. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 2014;156:1045-59 pubmed publisher
    ..paperclip: ..
  27. Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol. 2014;14:392-404 pubmed publisher
    ..In this Review, we discuss the evidence that has dramatically changed our understanding of monocyte and macrophage development, and the maintenance of these cells in the steady state...
  28. Amirav I, Wallmeier J, Loges N, Menchen T, Pennekamp P, Mussaffi H, et al. Systematic Analysis of CCNO Variants in a Defined Population: Implications for Clinical Phenotype and Differential Diagnosis. Hum Mutat. 2016;37:396-405 pubmed publisher
  29. Fischer K, Ruiz H, Jhun K, Finan B, Oberlin D, van der Heide V, et al. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. Nat Med. 2017;23:623-630 pubmed publisher
    ..Thus, we conclude that alternatively activated macrophages do not synthesize relevant amounts of catecholamines, and hence, are not likely to have a direct role in adipocyte metabolism or adaptive thermogenesis. ..
  30. Ner Gaon H, Melchior A, Golan N, Ben Haim Y, Shay T. JingleBells: A Repository of Immune-Related Single-Cell RNA-Sequencing Datasets. J Immunol. 2017;198:3375-3379 pubmed publisher
    ..Thus JingleBells is a resource that will extend the usefulness of scRNA-seq datasets outside the programming aficionado realm. ..
  31. Lotem J, Sachs L. Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone. Cell Growth Differ. 1995;6:647-53 pubmed
  32. Burgess H, Martinez S, Reiner O. KIAA0369, doublecortin-like kinase, is expressed during brain development. J Neurosci Res. 1999;58:567-75 pubmed
  33. Shav Tal Y, Lee B, Bar Haim S, Vandekerckhove J, Zipori D. Enhanced proteolysis of pre-mRNA splicing factors in myeloid cells. Exp Hematol. 2000;28:1029-38 pubmed
    ..Proteolytic degradation of PSF specifically occurs in intact myeloid cells and this process is enhanced upon myeloid cell lysis. ..
  34. Paperna I, Son R. Light microscopical structure and ultrastructure of a Besnoitia sp. in the naturally infected lizard Ameiva ameiva (Teiidae) from north Brazil, and in experimentally infected mice. Parasitology. 2001;123:247-55 pubmed
    ..No evidence of infection could be detected in these animals after feeding them with the tissues of mice harbouring cysts with very large number of bradyzoites...
  35. Shternhall Ron K, Quintana F, Perl S, Meivar Levy I, Barshack I, Cohen I, et al. Ectopic PDX-1 expression in liver ameliorates type 1 diabetes. J Autoimmun. 2007;28:134-42 pubmed
    ..Our findings suggest a beneficial therapeutic effect of the PDX-1 gene therapy for treating autoimmune type 1 diabetes mellitus (T1DM). ..
  36. Laviad E, Albee L, Pankova Kholmyansky I, Epstein S, Park H, Merrill A, et al. Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. J Biol Chem. 2008;283:5677-84 pubmed publisher
  37. Pasvolsky R, Grabovsky V, Giagulli C, Shulman Z, Shamri R, Feigelson S, et al. RhoA is involved in LFA-1 extension triggered by CXCL12 but not in a novel outside-in LFA-1 activation facilitated by CXCL9. J Immunol. 2008;180:2815-23 pubmed
  38. Ben Moshe T, Kang T, Kovalenko A, Barash H, Abramovitch R, Galun E, et al. Cell-autonomous and non-cell-autonomous functions of caspase-8. Cytokine Growth Factor Rev. 2008;19:209-17 pubmed publisher
  39. Brody R, Peleg E, Grossman E, Sharabi Y. Production and secretion of adiponectin from 3T3-L1 adipocytes: comparison of antihypertensive drugs. Am J Hypertens. 2009;22:1126-9 pubmed publisher
    ..05 for both compared to the control). In this comparative model, telmisartan, and to a lesser extent, losartan, increased production and secretion of adiponectin from 3T3-L1 adipocytes compared to the other antihypertensive drugs. ..
  40. Yatuv R, Robinson M, Dayan Tarshish I, Baru M. The use of PEGylated liposomes in the development of drug delivery applications for the treatment of hemophilia. Int J Nanomedicine. 2010;5:581-91 pubmed
    ..These improvements seem to arise from the association of formulated proteins with platelets prior to induction of coagulation. ..
  41. Zigdon H, Kogot Levin A, Park J, Goldschmidt R, Kelly S, Merrill A, et al. Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain. J Biol Chem. 2013;288:4947-56 pubmed publisher
    ..These results are of relevance for understanding modulation of ROS signaling by sphingolipids. ..
  42. Shechter R, Miller O, Yovel G, Rosenzweig N, London A, Ruckh J, et al. Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity. 2013;38:555-69 pubmed publisher
    ..Overall, our finding demonstrates that the route of monocyte entry to central nervous system provides an instructional environment to shape their function. ..
  43. Garin Shkolnik T, Rudich A, Hotamisligil G, Rubinstein M. FABP4 attenuates PPAR? and adipogenesis and is inversely correlated with PPAR? in adipose tissues. Diabetes. 2014;63:900-11 pubmed publisher
    ..Suppression of PPAR? by FABP4 in visceral fat may explain the reported role of FABP4 in the development of obesity-related morbidities, including insulin resistance, diabetes, and atherosclerosis. ..
  44. Lee J, Hsu C, Michael M, Nanda A, Liu L, McMillan J, et al. Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23. Am J Hum Genet. 2017;100:364-370 pubmed publisher
  45. Wolf Y, Boura Halfon S, Cortese N, Haimon Z, Sar Shalom H, Kuperman Y, et al. Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure. Nat Immunol. 2017;18:665-674 pubmed publisher
    ..Collectively, we report a previously unappreciated homeostatic role for macrophages in the control of tissue innervation. Disruption of this circuit in BAT resulted in metabolic imbalance. ..
  46. Harroch S, Gothelf Y, Revel M, Chebath J. 5' upstream sequences of MyD88, an IL-6 primary response gene in M1 cells: detection of functional IRF-1 and Stat factors binding sites. Nucleic Acids Res. 1995;23:3539-46 pubmed
    ..IRF1, an activator of transcription, is also induced to bind to this sequence at later times. A model of persistent activation of MyD88 gene through these two types of factors is proposed. ..
  47. Volberg T, Romer L, Zamir E, Geiger B. pp60(c-src) and related tyrosine kinases: a role in the assembly and reorganization of matrix adhesions. J Cell Sci. 2001;114:2279-89 pubmed
    ..These findings demonstrate that Src family kinases, and pp60(c-src) in particular, have a central role in regulating protein dynamics at cell-matrix interfaces, both during early stages of interaction and in mature focal contacts. ..
  48. Toledano Katchalski H, Kraut J, Sines T, Granot Attas S, Shohat G, Gil Henn H, et al. Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases. Mol Cancer Res. 2003;1:541-50 pubmed
  49. Zhang P, Izrael M, Ainbinder E, Ben Simchon L, Chebath J, Revel M. Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/soluble interleukin-6 receptor fusion protein. Mol Cell Neurosci. 2006;31:387-98 pubmed
    ..IL6RIL6 acts as an effective stimulator of the myelinating function of ES cell-derived oligodendrocyte precursors, as observed upon transplantation of the IL6RIL6- pretreated cells into brain slices of MBP-deficient shiverer mice. ..
  50. Pick M, Perry C, Lapidot T, Guimaraes Sternberg C, Naparstek E, Deutsch V, et al. Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis. Blood. 2006;107:3397-406 pubmed
    ..Our findings implicate AChE-R in thrombopoietic recovery, suggesting new therapeutic modalities for supporting platelet production. ..
  51. Galski H, Sivan H, Lazarovici P, Nagler A. In vitro and in vivo reversal of MDR1-mediated multidrug resistance by KT-5720: implications on hematological malignancies. Leuk Res. 2006;30:1151-8 pubmed
    ..Therefore, KT-5720 can be considered as candidate for combination therapy in various hematological malignancies where Pgp activity is a major impediment for cure. ..
  52. Kaushansky N, Zilkha Falb R, Hemo R, Lassman H, Eisenstein M, Sas A, et al. Pathogenic T cells in MOBP-induced murine EAE are predominantly focused to recognition of MOBP21F and MOBP27P epitopic residues. Eur J Immunol. 2007;37:3281-92 pubmed
    ..Such focused epitopic recognition may affect profoundly on peripheral self-tolerance to MOBP and on potential altered peptide ligand-mediated therapy of MOBP-related autoimmune pathogenesis. ..
  53. Farkash Amar S, Lipson D, Polten A, Goren A, Helmstetter C, Yakhini Z, et al. Global organization of replication time zones of the mouse genome. Genome Res. 2008;18:1562-70 pubmed publisher
    ..These findings, along with the strong conservation found between replication timing in human and mouse genomes, emphasize the importance of replication timing in transcription regulation. ..
  54. Lustig S, Maik Rachline G, Paran N, Melamed S, Israely T, Erez N, et al. Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response. Vaccine. 2009;27:1691-9 pubmed publisher
    ..Vaccine efficiency is not impaired, providing a non-prohibitive VIG dose is used. Thus, VIG can be used as a prophylactic measure against post-vaccinal complications but could also serve for post-exposure treatment against smallpox. ..
  55. Kaisman Elbaz T, Sekler I, Fishman D, Karol N, Forberg M, Kahn N, et al. Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules. J Cell Physiol. 2009;220:222-9 pubmed publisher
    ..Taken together, our results indicate that Zn(2+) and Cd(2+) influx induce expression and secretion of clusterin, thereby linking metal homeostasis and germ cell fate...
  56. Ohayon A, Babichev Y, Galperin M, Altman A, Isakov N. Widespread expression of PICOT in mouse and human tissues with predominant localization to epithelium. J Histochem Cytochem. 2010;58:799-806 pubmed publisher
  57. Addadi Y, Moskovits N, Granot D, Lozano G, Carmi Y, Apte R, et al. p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner. Cancer Res. 2010;70:9650-8 pubmed publisher
    ..Moreover, expression of mutant p53 by tumor stroma fibroblasts might exert a gain of function effect, further accelerating tumor development. ..
  58. Shoval Y, Berissi H, Kimchi A, Pietrokovski S. New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform. PLoS ONE. 2011;6:e17344 pubmed publisher
  59. Iskovich S, Goldenberg Cohen N, Stein J, Yaniv I, Fabian I, Askenasy N. Elutriated stem cells derived from the adult bone marrow differentiate into insulin-producing cells in vivo and reverse chemical diabetes. Stem Cells Dev. 2012;21:86-96 pubmed publisher
    ..Considering the extensive functional incorporation of insulin-producing donor cells in the injured islets, we conclude that the adult bone marrow contains a subset of small cells endowed with plastic developmental capacity. ..
  60. Sharir A, Stern T, Rot C, Shahar R, Zelzer E. Muscle force regulates bone shaping for optimal load-bearing capacity during embryogenesis. Development. 2011;138:3247-59 pubmed publisher
    ..Our findings invoke a common mechanism that permits the formation of different circumferential outlines in different bones. ..
  61. Levanon D, Bernstein Y, Negreanu V, Bone K, Pozner A, Eilam R, et al. Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function. EMBO Mol Med. 2011;3:593-604 pubmed publisher
    ..The lack of evidence for Runx3 expression in normal GIT Ep creates a serious challenge to the published data and undermines the notion that Runx3 is a TS involved in cancer pathogenesis. ..
  62. Goldfarb Y, Kadouri N, Levi B, Sela A, Herzig Y, Cohen R, et al. HDAC3 Is a Master Regulator of mTEC Development. Cell Rep. 2016;15:651-665 pubmed publisher
    ..Thus, our findings uncover yet another layer of complexity of TEC lineage divergence and highlight Hdac3 as a major and specific molecular switch crucial for mTEC differentiation. ..
  63. Sprecher E, David D, Yadin H, Peleg B, Becker Y. Mouse footpad Langerhans cells as an indicator for safety of foot and mouth disease virus vaccines. J Virol Methods. 1990;29:189-96 pubmed
  64. Haran Ghera N, Peled A, Canaani E, Caspi Y, Haimovich J, Shaft D, et al. The effects of passive anti-viral immunotherapy in AKR mice: II. Susceptibility to B cell lymphomagenesis. Leukemia. 1995;9:1940-7 pubmed
  65. Reiner O, Albrecht U, Gordon M, Chianese K, Wong C, Gal Gerber O, et al. Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration. J Neurosci. 1995;15:3730-8 pubmed
    ..The direct correlation between cortical defects in MDS patients and Lis1 expression in the murine cortex suggest that the mouse is a model system suitable to study the mechanistic basis of this intriguing genetic disease. ..
  66. Fishburn C, Belleli D, David C, Carmon S, Fuchs S. A novel short isoform of the D3 dopamine receptor generated by alternative splicing in the third cytoplasmic loop. J Biol Chem. 1993;268:5872-8 pubmed
    ..This suggests that an internal acceptor site in the exon coding for the distal part of the third cytoplasmic loop directs alternative splicing of the D3 dopamine receptor. ..
  67. Benayahu D, Efrati M, Wientroub S. Monoclonal antibodies recognize antigen expressed by osteoblasts. J Bone Miner Res. 1995;10:1496-503 pubmed
    ..Western blotting and immunoprecipitation indicated that the antigen that was recognized by MMS-85/12 apparently had a molecular weight of 84 dD. ..
  68. Sharabi Y, Grossman E, Sherer Y, Shaish A, Levkovitz H, Bitzur R, et al. The effect of renin-angiotensin axis inhibition on early atherogenesis in LDL-receptor-deficient mice. Pathobiology. 2000;68:270-4 pubmed
    ..Inhibition of the renin-angiotensin-aldosterone axis by itself does not prevent the development of early atherosclerosis in LDL-receptor-deficient mice. ..
  69. Nili E, Cojocaru G, Kalma Y, Ginsberg D, Copeland N, Gilbert D, et al. Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci. 2001;114:3297-307 pubmed
    ..Co-expression of both LAP2beta and mGCL with the E2F-DP complex resulted in a reduced transcriptional activity equal to that exerted by the pRb protein. ..
  70. Hazkani Covo E, Altman N, Horowitz M, Graur D. The evolutionary history of prosaposin: two successive tandem-duplication events gave rise to the four saposin domains in vertebrates. J Mol Evol. 2002;54:30-4 pubmed
    ..Accordingly, an ancestral saposin-unit duplication produced a two-domain gene, which, subsequently, underwent a second complete tandem duplication to give rise to the present four-domain structure of the prosaposin gene. ..
  71. Rozenfeld Granot G, Krishnamurthy J, Kannan K, Toren A, Amariglio N, Givol D, et al. A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1. Oncogene. 2002;21:1469-76 pubmed
    ..These results suggests the existence of a tightly controlled self amplifying mechanism of transcriptional activation leading to apoptosis by p53. ..
  72. Dafni H, Israely T, Bhujwalla Z, Benjamin L, Neeman M. Overexpression of vascular endothelial growth factor 165 drives peritumor interstitial convection and induces lymphatic drain: magnetic resonance imaging, confocal microscopy, and histological tracking of triple-labeled albumin. Cancer Res. 2002;62:6731-9 pubmed
    ..These results revealed a direct link between expression of VEGF165 and peritumor lymphatic drain, thus suggesting a possible role for tumor-derived VEGF in metastatic spread to sentinel lymph nodes. ..
  73. Tiran Z, Peretz A, Attali B, Elson A. Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon. J Biol Chem. 2003;278:17509-14 pubmed
    ..Together, these results indicate that Tyr(124) is a significant site at which the mutually antagonistic activities of Src and cyt-PTPepsilon affect Kv2.1 phosphorylation and activity. ..
  74. Zhang P, Chebath J, Lonai P, Revel M. Enhancement of oligodendrocyte differentiation from murine embryonic stem cells by an activator of gp130 signaling. Stem Cells. 2004;22:344-54 pubmed
    ..We conclude that this cytokine can significantly enhance the derivation of oligodendrocytes from ES cells. ..
  75. Asna N, Lewy H, Ashkenazi I, Deutsch V, Peretz H, Inbar M, et al. Time dependent protection of amifostine from renal and hematopoietic cisplatin induced toxicity. Life Sci. 2005;76:1825-34 pubmed
    ..The results also further validate the notion that chronochemotherapy is advantageous at least in reducing drug toxicity and thus should be integrated in the design of clinical protocols. ..
  76. Dar A, Goichberg P, Shinder V, Kalinkovich A, Kollet O, Netzer N, et al. Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells. Nat Immunol. 2005;6:1038-46 pubmed
    ..Thus, chemokine translocation across the blood-bone marrow barrier allows effective transfer of functional SDF-1 from the periphery to the stem cell niche in the bone marrow during both homeostasis and 'alarm' situations. ..
  77. Pilpel Y, Segal M. Rapid WAVE dynamics in dendritic spines of cultured hippocampal neurons is mediated by actin polymerization. J Neurochem. 2005;95:1401-10 pubmed
  78. Avkin S, Sevilya Z, Toube L, Geacintov N, Chaney S, Oren M, et al. p53 and p21 regulate error-prone DNA repair to yield a lower mutation load. Mol Cell. 2006;22:407-13 pubmed
    ..Loss of this regulation by inactivation of p53 or p21 causes an out of control lesion-bypass activity, which increases the mutational load and might therefore play a role in pathogenic processes caused by genetic instability. ..
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