Experts and Doctors on messenger rna in Switzerland

Summary

Locale: Switzerland
Topic: messenger rna

Top Publications

  1. Hoffmann F, Fournier D, Spierer P. Minigene rescues acetylcholinesterase lethal mutations in Drosophila melanogaster. J Mol Biol. 1992;223:17-22 pubmed
    ..The way is open to study in vivo the structure-function relationships of acetylcholinesterase and insecticide resistance. ..
  2. Preker P, Lingner J, Minvielle Sebastia L, Keller W. The FIP1 gene encodes a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase. Cell. 1995;81:379-89 pubmed
    ..We propose a model in which PF I tethers PAP1 to CF I, thereby conferring specificity to poly(A) polymerase for pre-mRNA substrates. ..
  3. Gotta M, Laroche T, Formenton A, Maillet L, Scherthan H, Gasser S. The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae. J Cell Biol. 1996;134:1349-63 pubmed
    ..Nonetheless, the Y' FISH is altered in a qualitative manner in sir3 and sir4 mutant strains, consistent with the previously reported phenotypes of shortened telomeric repeats and loss of telomeric silencing. ..
  4. Bontron S, Steimle V, Ucla C, Eibl M, Mach B. Two novel mutations in the MHC class II transactivator CIITA in a second patient from MHC class II deficiency complementation group A. Hum Genet. 1997;99:541-6 pubmed
    ..Molecular analysis of these two novel mutations, together with the one described earlier in the first patient, is informative in terms of CIITA structure-function relationships. ..
  5. Zurbriggen A, Schmid I, Graber H, Vandevelde M. Oligodendroglial pathology in canine distemper. Acta Neuropathol. 1998;95:71-7 pubmed
    ..We could demonstrate that CDV infection leads to massive down-regulation of myelin gene expression in demyelinating lesions and that this effect correlates in part with a restricted infection of oligodendrocytes...
  6. Puntschart A, Wey E, Jostarndt K, Vogt M, Wittwer M, Widmer H, et al. Expression of fos and jun genes in human skeletal muscle after exercise. Am J Physiol. 1998;274:C129-37 pubmed
    ..The signals leading to the expression of these immediate early genes are therefore unclear. ..
  7. Ebel C, Frantz C, Paulus F, Imbault P. Trans-splicing and cis-splicing in the colourless Euglenoid, Entosiphon sulcatum. Curr Genet. 1999;35:542-50 pubmed
    ..sulcatum beta-tubulin gene has the intron borders GU-AG, typical of spliceosome-matured introns which have not yet been found in E. gracilis. The probable origins of trans- and cis-mechanisms in Euglenoids are discussed...
  8. Raasi S, Schmidtke G, de Giuli R, Groettrup M. A ubiquitin-like protein which is synergistically inducible by interferon-gamma and tumor necrosis factor-alpha. Eur J Immunol. 1999;29:4030-6 pubmed
    ..A general and synergistic induction with IFN-gamma and TNF-alpha suggests that diubiquitin may exert its functions in antigen presentation or other cellular processes controlled by these two cytokines. ..
  9. Burri L, Höckendorff J, Boehm U, Klamp T, Dohmen R, Levy F. Identification and characterization of a mammalian protein interacting with 20S proteasome precursors. Proc Natl Acad Sci U S A. 2000;97:10348-53 pubmed
    ..We also show that the transcript level of mammalian UMP1 is increased after IFN-gamma treatment and that mammalian UMP1 is functionally related to but not interchangeable with its yeast homologue. ..

More Information

Publications219 found, 100 shown here

  1. Grotzer M, Janss A, Phillips P, Trojanowski J. Neurotrophin receptor TrkC predicts good clinical outcome in medulloblastoma and other primitive neuroectodermal brain tumors. Klin Padiatr. 2000;212:196-9 pubmed
    ..00005). The TrkC neurotrophin receptor appears to be a powerful independent prognostic factor in PNET and may have a role in patient assignment to risk-based treatment strategies. ..
  2. Bodendorf U, Fischer F, Bodian D, Multhaup G, Paganetti P. A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein. J Biol Chem. 2001;276:12019-23 pubmed
    ..Our findings suggest that tissue-specific splicing of the BACE mRNA may explain the observation that in the human pancreas robust transcription of the BACE gene does not translate into recovered enzymatic activity. ..
  3. Bisset L, Bosbach S, Tomasik Z, Lutz H, Schupbach J, Boni J. Quantification of in vitro retroviral replication using a one-tube real-time RT-PCR system incorporating direct RNA preparation. J Virol Methods. 2001;91:149-55 pubmed
  4. Paratore C, Goerich D, Suter U, Wegner M, Sommer L. Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling. Development. 2001;128:3949-61 pubmed
    ..Failures in fate decision processes might thus contribute to the etiology of Waardenburg/Hirschsprung disease. ..
  5. le Mercier P, Garcin D, Garcia E, Kolakofsky D. Competition between the Sendai virus N mRNA start site and the genome 3'-end promoter for viral RNA polymerase. J Virol. 2003;77:9147-55 pubmed
  6. Mahé C, Loetscher E, Dev K, Bobirnac I, Otten U, Schoeffter P. Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells. Neuropharmacology. 2005;49:40-7 pubmed
    ..These data show that functional 5-HT7 receptors are present in human microglial MC-3 cells, suggesting that they are involved in neuroinflammatory processes...
  7. Franchini M, Schweizer M, Mätzener P, Magkouras I, Sauter K, Mirkovitch J, et al. Evidence for dissociation of TLR mRNA expression and TLR agonist-mediated functions in bovine macrophages. Vet Immunol Immunopathol. 2006;110:37-49 pubmed
    ..Thus, the amount of TLR2, TLR3 and TLR4 mRNA transcripts is stable at least under the conditions tested. More importantly, modulation of TLR-mediated responses was dissociated from mRNA expression of TLR members. ..
  8. Spinedi E, Voirol M, Verdumo C, Giacominni M, Pralong F, Gaillard R. Hypothalamic ghrelin treatment modulates NPY-but not CRH-ergic activity in adrenalectomized rats subjected to food restriction: Evidence of a novel hypothalamic ghrelin effect. Endocrine. 2006;29:477-84 pubmed
    ..Our data indicate an inhibitory effect of hypothalamic ghrelin on NPY-ergic activity in FR rats lacking endogenous glucocorticoid. ..
  9. Hornemann T, Richard S, Rütti M, Wei Y, von Eckardstein A. Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase. J Biol Chem. 2006;281:37275-81 pubmed
    ..The expression of two SPT isoforms could be a cellular mechanism to adjust SPT activity to tissue-specific requirements of sphingolipid synthesis. ..
  10. Chalmel F, Rolland A, Niederhauser Wiederkehr C, Chung S, Demougin P, Gattiker A, et al. The conserved transcriptome in human and rodent male gametogenesis. Proc Natl Acad Sci U S A. 2007;104:8346-51 pubmed
    ..Expression profiling data further identified numerous conserved genes of biological and clinical interest previously unassociated with the mammalian male germ line. ..
  11. Acosta Rodriguez E, Rivino L, Geginat J, Jarrossay D, Gattorno M, Lanzavecchia A, et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol. 2007;8:639-46 pubmed
    ..Our results demonstrate that human T(H)-17 cells have distinct migratory capacity and antigenic specificities and establish a link between microbial products, T helper cell differentiation and homing in response to fungal antigens. ..
  12. Gao S, De Geyter C, Kossowska K, Zhang H. FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles. Mol Hum Reprod. 2007;13:465-71 pubmed
    ..These studies provide the first evidence that ADAMTS-16 is an active protease and suggest a physiological role of ADAMTS-16 in ovarian follicles, at least during the pre-ovulatory phase. ..
  13. Boehringer D, Ban N. Trapping the ribosome to control gene expression. Cell. 2007;130:983-5 pubmed
    ..These results have implications for our understanding of the mechanism of translation initiation in general. ..
  14. Bochud M, Bovet P, Burnier M, Eap C. CYP3A5 and ABCB1 genes and hypertension. Pharmacogenomics. 2009;10:477-87 pubmed publisher
    ..If the role of these genes in blood pressure control is confirmed in other populations and other ethnic groups, these findings would point toward a new pathway for blood pressure control in humans. ..
  15. Ontsouka C, Burgener I, Mani O, Albrecht C. Polyunsaturated fatty acid-enriched diets used for the treatment of canine chronic enteropathies decrease the abundance of selected genes of cholesterol homeostasis. Domest Anim Endocrinol. 2010;38:32-7 pubmed publisher
    ..05) by PUFA-enriched diets in IBD dogs only. Our results suggest that feeding PUFA-enriched diets may alter cholesterol homeostasis in duodenal mucosal cells of dogs suffering from IBD...
  16. Hausser J, Landthaler M, Jaskiewicz L, Gaidatzis D, Zavolan M. Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C-miRNA complexes and the degradation of miRNA targets. Genome Res. 2009;19:2009-20 pubmed publisher
    ..We found that structural features of the target site are only important for Argonaute/EIF2C binding, while sequence features such as the A/U content of the 3' UTR are important for mRNA degradation. ..
  17. Talarek N, Cameroni E, Jaquenoud M, Luo X, Bontron S, Lippman S, et al. Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway. Mol Cell. 2010;38:345-55 pubmed publisher
    ..These results delineate a likely conserved mechanism by which nutrient limitation leads to stabilization of specific mRNAs that are critical for cell differentiation and life span. ..
  18. Rebmann G, Mauch F, Dudler R. Sequence of a wheat cDNA encoding a pathogen-induced thaumatin-like protein. Plant Mol Biol. 1991;17:283-5 pubmed
  19. Vazquez J. Response to heat shock of gene 1, a Drosophila melanogaster small heat shock gene, is developmentally regulated. Mol Gen Genet. 1991;226:393-400 pubmed
    ..Furthermore, S1 nuclease mapping analysis revealed several gene 1 mRNA species, which are generated by the use of alternative polyadenylation sites and by the use of differentially regulated transcriptional initiation sites. ..
  20. Chaponnier C, Kocher O, Gabbiani G. Modulation of gelsolin content in rat aortic smooth muscle cells during development, experimental intimal thickening and culture. An immunohistochemical and biochemical study. Eur J Biochem. 1990;190:559-65 pubmed
    ..The similar modulation patterns of gelsolin and alpha-SM actin suggest a preferential interaction between these two proteins. ..
  21. Bauer S, Kudo A, Melchers F. Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species. EMBO J. 1988;7:111-6 pubmed
    ..the human VpreB gene appears to be selectively expressed in human pre-B cell lines as an 0.85 kb poly(A)+ RNA. Its expression promises to be a useful marker for the detection of normal and malignant human pre-B lymphocytes. ..
  22. Pott U, Thiesen H, Colello R, Schwab M. A new Cys2/His2 zinc finger gene, rKr2, is expressed in differentiated rat oligodendrocytes and encodes a protein with a functional repressor domain. J Neurochem. 1995;65:1955-66 pubmed
  23. Cléard F, Matsarskaia M, Spierer P. The modifier of position-effect variegation Suvar(3)7 of Drosophila: there are two alternative transcripts and seven scattered zinc fingers, each preceded by a tryptophan box. Nucleic Acids Res. 1995;23:796-802 pubmed
    ..The ubiquitous distribution of transcripts in embryos and the different sequence motifs support our speculation that the locus encodes a chromosomal protein implicated in heterochromatin-mediated DNA silencing. ..
  24. Giger R, Vogt L, Zuellig R, Rader C, Henehan Beatty A, Wolfer D, et al. The gene of chicken axonin-1. Complete structure and analysis of the promoter. Eur J Biochem. 1995;227:617-28 pubmed
    ..A second AP-2 binding site and a homeodomain protein binding site are located within exon 1. ..
  25. Sappino A, Madani R, Huarte J, Belin D, Kiss J, Wohlwend A, et al. Extracellular proteolysis in the adult murine brain. J Clin Invest. 1993;92:679-85 pubmed
    ..The identification of an extracellular proteolytic system active in the adult central nervous system may also help gain insights into the pathogeny of neurodegenerative disorders associated with extracellular protein deposition. ..
  26. French L, Hahne M, Viard I, Radlgruber G, Zanone R, Becker K, et al. Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover. J Cell Biol. 1996;133:335-43 pubmed
    ..It may be, therefore, that the Fas system is implicated in both the regulation of physiological cell turnover and the protection of particular tissues against potential lymphocyte-mediated damage. ..
  27. Belluoccio D, Trueb B. Matrilin-3 from chicken cartilage. FEBS Lett. 1997;415:212-6 pubmed
    ..The primary structure is similar to that of matrilin-1 which is also expressed in a cartilage-specific manner. This similarity suggests that the genes for the two proteins may have evolved from a common ancestor by gene duplication. ..
  28. Elson G, Graber P, Losberger C, Herren S, Gretener D, Menoud L, et al. Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family. J Immunol. 1998;161:1371-9 pubmed
    ..These results suggest that CLF-1 is a novel soluble cytokine receptor subunit or part of a novel cytokine complex, possibly playing a regulatory role in the immune system and during fetal development. ..
  29. Mery L, Magnino F, Schmidt K, Krause K, Dufour J. Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors. FEBS Lett. 2001;487:377-83 pubmed
    ..Thus, we describe a novel interaction between Trp proteins and InsP3R and we provide evidence suggesting that the formation of hTrp4-InsP3R complexes may be regulated by alternative splicing. ..
  30. Lang C, Schafer M, Varga L, Zimmermann A, Krahenbuhl S, Krahenbuhl L. Hepatic and skeletal muscle glycogen metabolism in rats with short-term cholestasis. J Hepatol. 2002;36:22-9 pubmed
  31. Hannon J, Petrucci C, Fehlmann D, Viollet C, Epelbaum J, Hoyer D. Somatostatin sst2 receptor knock-out mice: localisation of sst1-5 receptor mRNA and binding in mouse brain by semi-quantitative RT-PCR, in situ hybridisation histochemistry and receptor autoradiography. Neuropharmacology. 2002;42:396-413 pubmed
    ..Finally, since the relative distribution of these two ligands were not entirely superimposable, it suggests that their respective selectivity profiles towards the different SRIF receptor subtypes in situ are not identical. ..
  32. Audigé A, Yu Z, Frey B, Uehlinger D, Frey F, Vogt B. Epithelial sodium channel (ENaC) subunit mRNA and protein expression in rats with puromycin aminonucleoside-induced nephrotic syndrome. Clin Sci (Lond). 2003;104:389-95 pubmed
    ..In conclusion, ENaC mRNA expression, especially alphaENaC, is increased in the very early phase of the experimental model of PAN-induced nephrotic syndrome in rats, but appears to escape from the regulation by aldosterone after day 3. ..
  33. Zheng M, Simon R, Mirlacher M, Maurer R, Gasser T, Forster T, et al. TRIO amplification and abundant mRNA expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer. Am J Pathol. 2004;165:63-9 pubmed
    ..It is concluded that TRIO up-regulation through amplification has a potential role in bladder cancer progression. ..
  34. Biecker E, Neef M, Sägesser H, Shaw S, Koshy A, Reichen J. Nitric oxide synthase 1 is partly compensating for nitric oxide synthase 3 deficiency in nitric oxide synthase 3 knock-out mice and is elevated in murine and human cirrhosis. Liver Int. 2004;24:345-53 pubmed
    ..Upregulation of NOS-1 mRNA levels in hepatic arteries of portal hypertensive patients suggests possible clinical significance for these experimental findings. ..
  35. Iynedjian P. Lack of evidence for a role of TRB3/NIPK as an inhibitor of PKB-mediated insulin signalling in primary hepatocytes. Biochem J. 2005;386:113-8 pubmed
    ..No significant change in mRNA level occurred under any of the hormonal treatments. The present study does not support the hypothesis that the physiological role of TRB3/NIPK might be to put a brake on insulin signalling in hepatocytes. ..
  36. Krawczyk M, Masternak K, Zufferey M, Barras E, Reith W. New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study. Mol Cell Biol. 2005;25:8607-18 pubmed
  37. Meier K, Deloche O, Kajiwara K, Funato K, Riezman H. Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae. Mol Biol Cell. 2006;17:1164-75 pubmed
    ..Taken together, we have shown a requirement for sphingoid bases during the recovery from heat shock and suggest that this reflects a direct lipid-dependent signal to the cap-dependent translation initiation apparatus. ..
  38. Grad S, Lee C, Wimmer M, Alini M. Chondrocyte gene expression under applied surface motion. Biorheology. 2006;43:259-69 pubmed
    ..These results demonstrate the beneficial effect of articular motion not only for stimulation of important lubricating molecules, but also for the preservation of the chondrocytic phenotype. ..
  39. Frigerio F, Chaffard G, Berwaer M, Maechler P. The antiepileptic drug topiramate preserves metabolism-secretion coupling in insulin secreting cells chronically exposed to the fatty acid oleate. Biochem Pharmacol. 2006;72:965-73 pubmed
    ..The data demonstrate that a drug originally used as mood stabilizer exerts a direct action on beta-cells, protecting against lipid-induced dysfunction. ..
  40. Lapouge K, Schubert M, Allain F, Haas D. Gac/Rsm signal transduction pathway of gamma-proteobacteria: from RNA recognition to regulation of social behaviour. Mol Microbiol. 2008;67:241-53 pubmed
    ..Unidentified signal molecules co-ordinate the activity of the Gac/Rsm cascade in a cell population density-dependent manner. ..
  41. Montag Sallaz M, Montag D, Schachner M. Altered processing of novel information in N-CAM-deficient mice. Neuroreport. 2003;14:1343-6 pubmed
    ..1/arc expression in the cingulate cortex 4.5 h after the novel taste was not observed in N-CAM-deficient mice. These data suggest that information processing mediated by immediate-early gene expression is altered in N-CAM-deficient mice. ..
  42. Neef M, Ledermann M, Saegesser H, Schneider V, Widmer N, Decosterd L, et al. Oral imatinib treatment reduces early fibrogenesis but does not prevent progression in the long term. J Hepatol. 2006;44:167-75 pubmed
    ..The antifibrotic effectiveness of imatinib is limited to the early phase of fibrogenesis. In ongoing liver injury other mediators most likely compensate for the inhibited PDGF effect. ..
  43. Escher P, Cottet S, Aono S, Oohira A, Schorderet D. Differential neuroglycan C expression during retinal degeneration in Rpe65-/- mice. Mol Vis. 2008;14:2126-35 pubmed
    ..During retinal degeneration in Rpe65-/- mice, NGC expression is induced in the neural retina, but not in the RPE, where NGC is expressed at highest levels. ..
  44. Garcin D, Rochat S, Kolakofsky D. The Tacaribe arenavirus small zinc finger protein is required for both mRNA synthesis and genome replication. J Virol. 1993;67:807-12 pubmed
    ..Our results suggest that the Z protein is required for both mRNA and genome synthesis, but in somewhat different manners...
  45. Pedrazzini T, Seydoux J, Künstner P, Aubert J, Grouzmann E, Beermann F, et al. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Nat Med. 1998;4:722-6 pubmed
    ..In addition, these data are also indicative of a role for the Y1 receptor in the control of food intake. ..
  46. Eriksson K, Makia D, Maier R, Cervantes L, Ludewig B, Thiel V. Efficient transduction of dendritic cells using coronavirus-based vectors. Adv Exp Med Biol. 2006;581:203-6 pubmed
  47. Basler K, Hafen E. Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain. Cell. 1988;54:299-311 pubmed
    ..A single amino acid substitution in the ATP-binding site of the putative kinase domain results in the synthesis of an inactive sev protein unable to determine cell fate. ..
  48. Preker P, Ohnacker M, Minvielle Sebastia L, Keller W. A multisubunit 3' end processing factor from yeast containing poly(A) polymerase and homologues of the subunits of mammalian cleavage and polyadenylation specificity factor. EMBO J. 1997;16:4727-37 pubmed
    ..PF I also appears to be functionally related to CPSF, as it polyadenylates a substrate RNA more efficiently than Pap1p alone. Possibly, the observed interaction of the complex with RNA tethers Pap1p to its substrate. ..
  49. Martin D, Zusman S, Li X, Williams E, Khare N, DaRocha S, et al. wing blister, a new Drosophila laminin alpha chain required for cell adhesion and migration during embryonic and imaginal development. J Cell Biol. 1999;145:191-201 pubmed
    ..Mutation analysis in the eye demonstrates a function in rhabdomere organization. In summary, this new laminin alpha chain is essential for embryonic viability and is involved in processes requiring cell migration and cell adhesion. ..
  50. Naula N, Walther C, Baumann D, Schweingruber M. Two non-complementing genes encoding enzymatically active methylenetetrahydrofolate reductases control methionine requirement in fission yeast Schizosaccharomyces pombe. Yeast. 2002;19:841-8 pubmed
  51. Wilson A, MacDonald H. Expression of genes encoding the pre-TCR and CD3 complex during thymus development. Int Immunol. 1995;7:1659-64 pubmed
    ..Detectable surface expression of both CD3 and TCR beta are delayed relative to expression of the corresponding genes, suggesting the existence of other (as yet unidentified) components of the pre-TCR complex. ..
  52. Hock C, Heese K, Muller Spahn F, Hulette C, Rosenberg C, Otten U. Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease. Neurosci Lett. 1998;241:151-4 pubmed
    ..These results reveal a central specific role of the high affinity NGF receptor during neurodegeneration in AD. ..
  53. Müller R, Hülsmeier A, Altmann F, Ten Hagen K, Tiemeyer M, Hennet T. Characterization of mucin-type core-1 beta1-3 galactosyltransferase homologous enzymes in Drosophila melanogaster. FEBS J. 2005;272:4295-305 pubmed
    ..melanogaster suggests an increased complexity of core-1 O-glycan expression, which is possibly related to multiple developmental and physiological functions attributable to this class of glycans. ..
  54. Preker P, Keller W. The HAT helix, a repetitive motif implicated in RNA processing. Trends Biochem Sci. 1998;23:15-6 pubmed
  55. Juge Aubry C, Somm E, Giusti V, Pernin A, Chicheportiche R, Verdumo C, et al. Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation. Diabetes. 2003;52:1104-10 pubmed
  56. Gertsch J, Schoop R, Kuenzle U, Suter A. Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways. FEBS Lett. 2004;577:563-9 pubmed
    ..This study is the first to report a possible molecular mechanism of action of Echinacea, highlighting the role of alkylamides as potent immunomodulators and potential ligands for CB2 receptors. ..
  57. Dichtl B, Blank D, Sadowski M, Hubner W, Weiser S, Keller W. Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination. EMBO J. 2002;21:4125-35 pubmed
    ..We propose that direct interactions of Yhh1p/Cft1p with both the RNA transcript and the CTD are required to communicate poly(A) site recognition to elongating pol II to initiate transcription termination. ..
  58. Durrer S, Maerkel K, Schlumpf M, Lichtensteiger W. Estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor. Endocrinology. 2005;146:2130-9 pubmed
    ..Our data indicate that developmental exposure to 4-MBC affects the regulation of estrogen target genes and the expression of nuclear receptor coregulators in uterus at mRNA and protein levels. ..
  59. Bady I, Marty N, Dallaporta M, Emery M, Gyger J, Tarussio D, et al. Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding. Diabetes. 2006;55:988-95 pubmed
    ..Furthermore, inactivation of these glucose sensors causes overeating. ..
  60. Karoubi G, Gugger M, Schmid R, Dutly A. OCT4 expression in human non-small cell lung cancer: implications for therapeutic intervention. Interact Cardiovasc Thorac Surg. 2009;8:393-7 pubmed publisher
    ..In addition, the aberrant expression and distribution of OCT4 may indicate important parameters concerning the differences between adenocarcinoma and BAC. ..
  61. Obexer Ruff G, Fluri A, Hein W, Lazary S, Peterhans E, Bertoni G. Caprine T-cell receptor variable beta-chain (TCRV beta) repertoire analysis and potential applications in cowdriosis immune response studies. Ann N Y Acad Sci. 1998;849:321-6 pubmed
    ..e., the Creole goat. There the TCR V beta repertoire analysis and kinetic study of the cowdriosis model will provide insight into the type of the immune response and the status of protection during the immunization process and challenge...
  62. Maerkel K, Durrer S, Henseler M, Schlumpf M, Lichtensteiger W. Sexually dimorphic gene regulation in brain as a target for endocrine disrupters: developmental exposure of rats to 4-methylbenzylidene camphor. Toxicol Appl Pharmacol. 2007;218:152-65 pubmed
    ..The data indicate profound sex- and region-specific alterations in the regulation of estrogen target genes at brain level. Effect patterns in baseline and E2-induced gene expression differ from those in uterus and prostate. ..
  63. Cmarko D, Bøe S, Scassellati C, Szilvay A, Davanger S, Fu X, et al. Rev inhibition strongly affects intracellular distribution of human immunodeficiency virus type 1 RNAs. J Virol. 2002;76:10473-84 pubmed
    ..This suggests that Rev is necessary and probably also sufficient for the accumulation of incompletely spliced HIV RNAs at the nuclear pores while CRM1 is needed for translocation across the nuclear pore complex. ..
  64. Koliopanos A, Friess H, Kleeff J, Shi X, Liao Q, Pecker I, et al. Heparanase expression in primary and metastatic pancreatic cancer. Cancer Res. 2001;61:4655-9 pubmed
    ..These results suggest that hpa overexpression in human pancreatic cancers facilitates cancer cell invasion, thereby enhancing the metastatic potential of the tumors. ..
  65. le Mercier P, Garcin D, Hausmann S, Kolakofsky D. Ambisense sendai viruses are inherently unstable but are useful to study viral RNA synthesis. J Virol. 2002;76:5492-502 pubmed
    ..The selection of mutants unable to express ambi-mRNA on passage in chicken eggs is presumably due to increased levels of dsRNA during infection. How natural ambisense viruses may deal with this dilemma is discussed. ..
  66. Bahi A, Boyer F, Bussard G, Dreyer J. Silencing dopamine D3-receptors in the nucleus accumbens shell in vivo induces changes in cocaine-induced hyperlocomotion. Eur J Neurosci. 2005;21:3415-26 pubmed
    ..Thus D(3)R expression significantly contributes to behavioural changes associated with chronic cocaine delivery. ..
  67. Shaw P, Walter Sierra R, Tamone F, Schibler U. Rapid identification of DNA fragments containing promoters for RNA polymerase II. Gene. 1989;84:371-81 pubmed
    ..Here, we demonstrate the applicability of this procedure by the isolation and characterization of several genomic DNA clones containing RNA polymerase II promoter sequences, that are highly active in liver. ..
  68. Fonjallaz P, Ossipow V, Wanner G, Schibler U. The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences. EMBO J. 1996;15:351-62 pubmed
    ..Our results suggest that the promoter environment, rather than the affinity with which PAR proteins recognize their cognate DNA sequences in vitro, determines the promoter preferences of TEF and DBP. ..
  69. Scheidegger P, Weiglhofer W, Suarez S, Kaser Hotz B, Steiner R, Ballmer Hofer K, et al. Vascular endothelial growth factor (VEGF) and its receptors in tumor-bearing dogs. Biol Chem. 1999;380:1449-54 pubmed
    ..Based on the literature and our study we suggest that the molecular biology and the function of the VEGF signaling system are virtually identical in humans and canines and in healthy as well as in disease conditions. ..
  70. Pantano S, Jarrossay D, Saccani S, Bosisio D, Natoli G. Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells. Exp Cell Res. 2006;312:1312-22 pubmed
    ..By regulating the induction of several genes implicated in the immune response, including inflammatory cytokines, chemokines and survival genes, BCL6 may represent a pivotal modulator of the afferent branch of the immune response. ..
  71. Maier S, Lutz R, Gelman L, Sarasa Renedo A, Schenk S, Grashoff C, et al. Tenascin-C induction by cyclic strain requires integrin-linked kinase. Biochim Biophys Acta. 2008;1783:1150-62 pubmed publisher
    ..Our results indicate that ILK is selectively required for the induction of specific genes by mechanical stimulation via RhoA-mediated pathways. ..
  72. Kuhn F, Andres A. pmg-1, a novel gene specifically expressed during the invasive growth phase of the mammary gland at puberty. FEBS Lett. 1997;413:65-9 pubmed
    ..To our knowledge this represents the first isolation of a gene specifically associated with the induction of mammary epithelial invasiveness at puberty. ..
  73. Beris P, Solenthaler M, Deutsch S, Darbellay R, Tobler A, Bochaton Pialat M, et al. Severe inclusion body beta-thalassaemia with haemolysis in a patient double heterozygous for beta(0)-thalassaemia and quadruplicated alpha-globin gene arrangement of the anti-4.2 type. Br J Haematol. 1999;105:1074-80 pubmed
  74. Höpfl G, Wenger R, Ziegler U, Stallmach T, Gardelle O, Achermann R, et al. Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor. Cancer Res. 2002;62:2962-70 pubmed
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