Genomes and Genes
Experts and Doctors on membrane proteins in United States
Locale: United States
Topic: membrane proteins
Publications574 found, 100 shown here
- Ansaldi M, Marolt D, Stebe T, Mandic Mulec I, Dubnau D. Specific activation of the Bacillus quorum-sensing systems by isoprenylated pheromone variants. Mol Microbiol. 2002;44:1561-73 pubmed..These results give new insights into peptidemediated quorum-sensing signalling in Gram-positive bacteria and emphasize the role of isoprenylation in bacterial signal transduction. ..
- Noh B, Bandyopadhyay A, Peer W, Spalding E, Murphy A. Enhanced gravi- and phototropism in plant mdr mutants mislocalizing the auxin efflux protein PIN1. Nature. 2003;423:999-1002 pubmed..Lateral auxin conductance becomes relatively larger as a result, enhancing the growth differentials responsible for tropic responses. ..
- Bullesbach E, Schwabe C. The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7. J Biol Chem. 2005;280:14051-6 pubmed..This model explains the exquisite sensitivity of relaxin binding avidity to minute changes in the disposition of the guanidinium and the size dependence of the hydrophobic binding residue in position B20. ..
- Tzeng Y, Ambrose K, Zughaier S, Zhou X, Miller Y, Shafer W, et al. Cationic antimicrobial peptide resistance in Neisseria meningitidis. J Bacteriol. 2005;187:5387-96 pubmed..The modification of meningococcal lipid A head groups with PEA also prevents neutralization of the biological effects of endotoxin by CAMP. ..
- Tang D, Ade J, Frye C, Innes R. Regulation of plant defense responses in Arabidopsis by EDR2, a PH and START domain-containing protein. Plant J. 2005;44:245-57 pubmed..The PH and START domains are implicated in lipid binding, suggesting that EDR2 may provide a link between lipid signaling and activation of programmed cell death mediated by mitochondria. ..
- Ioannidou S, Deinhardt K, Miotla J, Bradley J, Cheung E, Samuelsson S, et al. An in vitro assay reveals a role for the diaphragm protein PV-1 in endothelial fenestra morphogenesis. Proc Natl Acad Sci U S A. 2006;103:16770-5 pubmed..Together, these data provide insight into the cell biology of fenestra formation and open up the future study of the fenestra to a combined morphological and biochemical analysis. ..
- Ge Y, Rikihisa Y. Surface-exposed proteins of Ehrlichia chaffeensis. Infect Immun. 2007;75:3833-41 pubmed..The identification of E. chaffeensis surface-exposed proteins provides novel insights into the E. chaffeensis surface and lays the foundation for rational studies on pathogen-host interactions and vaccine development. ..
- Funk A, Rumbaugh G, Harotunian V, McCullumsmith R, Meador Woodruff J. Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia. Neuroreport. 2009;20:1019-22 pubmed publisher..These data suggest that NMDA receptor complex formation, localization, and downstream signaling may be abnormal in schizophrenia. ..
- Tallafuss A, Trepman A, Eisen J. DeltaA mRNA and protein distribution in the zebrafish nervous system. Dev Dyn. 2009;238:3226-36 pubmed publisher..In the adult brain, dla mRNA and Dla protein are expressed in proliferative zones normally associated with stem cells. ..
- Kuravi S, Lan T, Barik A, Lambert N. Third-party bioluminescence resonance energy transfer indicates constitutive association of membrane proteins: application to class a g-protein-coupled receptors and g-proteins. Biophys J. 2010;98:2391-9 pubmed publisher..We find that beta2 adrenoreceptors constitutively associate with each other and with several other class A GPCRs. In contrast, GPCRs and G-proteins are unlikely to exist in stable constitutive preassembled complexes. ..
- Balic A, Mina M. Characterization of progenitor cells in pulps of murine incisors. J Dent Res. 2010;89:1287-92 pubmed publisher..These results provide evidence that continuous generation of odontoblasts and dentin on the labial and lingual sides of unerupted and erupted incisors is supported by a progenitor population and not multipotent MSCs in the dental pulp. ..
- Li H, Zhong X, Chau K, Williams E, Chang Q. Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory. Nat Neurosci. 2011;14:1001-8 pubmed publisher..Our results suggest that NAIP of MeCP2 is required for modulating dynamic functions of the adult mouse brain. ..
- Zhao Y, Malinin N, Meller J, Ma Y, West X, Bledzka K, et al. Regulation of cell adhesion and migration by Kindlin-3 cleavage by calpain. J Biol Chem. 2012;287:40012-20 pubmed publisher..This represents a novel mechanism regulating reversibility of integrin adhesion complexes in leukocytes, which, in turn, is critical for their successful transmigration through the extracellular matrix. ..
- Asanov A, Sherry R, Sampieri A, Vaca L. A relay mechanism between EB1 and APC facilitate STIM1 puncta assembly at endoplasmic reticulum-plasma membrane junctions. Cell Calcium. 2013;54:246-56 pubmed publisher..These results together position APC as an important element in facilitating the translocation of STIM1 puncta near ER-PM junctions, which in turn is required for efficient SOCE and Orai activation upon depletion of the ER...
- Song M, Kim J, Liu L, Husain M, VÃ¡zquez Torres A. Antioxidant Defense by Thioredoxin Can Occur Independently of Canonical Thiol-Disulfide Oxidoreductase Enzymatic Activity. Cell Rep. 2016;14:2901-11 pubmed publisher..These findings suggest that the horizontally acquired virulence determinant SsrB is regulated post-translationally by ancestrally present thioredoxin. ..
- Parks A, Huppert S, Muskavitch M. The dynamics of neurogenic signalling underlying bristle development in Drosophila melanogaster. Mech Dev. 1997;63:61-74 pubmed..Within microchaeta proneural stripes, we demonstrate that Delta-Notch signalling prohibits adoption of the SOP fate by repressing expression of proneural genes. ..
- von Mollard G, Nothwehr S, Stevens T. The yeast v-SNARE Vti1p mediates two vesicle transport pathways through interactions with the t-SNAREs Sed5p and Pep12p. J Cell Biol. 1997;137:1511-24 pubmed..Therefore, a single v-SNARE can interact functionally with two different t-SNAREs in directing membrane traffic in yeast. ..
- Byrd C, Turner G, Varshavsky A. The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J. 1998;17:269-77 pubmed..cerevisiae. Thus, one physiological substrate of the N-end rule pathway functions as both a repressor of peptide import and a regulator of copper homeostasis. ..
- Higgs P, Myers P, Postle K. Interactions in the TonB-dependent energy transduction complex: ExbB and ExbD form homomultimers. J Bacteriol. 1998;180:6031-8 pubmed..The implications of these findings for the mechanism of TonB-dependent energy transduction are discussed. ..
- Smilinich N, Day C, Fitzpatrick G, Caldwell G, Lossie A, Cooper P, et al. A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome. Proc Natl Acad Sci U S A. 1999;96:8064-9 pubmed..We propose that KvDMR1 and/or its associated antisense RNA (KvLQT1-AS) represents an additional imprinting control element or center in the human 11p15.5 and mouse distal 7 imprinted domains. ..
- Beel B, Hazelbauer G. Substitutions in the periplasmic domain of low-abundance chemoreceptor trg that induce or reduce transmembrane signaling: kinase activation and context effects. J Bacteriol. 2001;183:671-9 pubmed
- Torres V, Cai Y, Chen X, Wu G, Geng L, Cleghorn K, et al. Vascular expression of polycystin-2. J Am Soc Nephrol. 2001;12:1-9 pubmed..These observations suggest a direct pathogenic role for PKD1 and PKD2 mutations in the vascular complications of ADPKD. ..
- Jiang W, Hermolin J, Fillingame R. The preferred stoichiometry of c subunits in the rotary motor sector of Escherichia coli ATP synthase is 10. Proc Natl Acad Sci U S A. 2001;98:4966-71 pubmed
- de la Fuente J, Kocan K. Expression of Anaplasma marginale major surface protein 2 variants in persistently infected ticks. Infect Immun. 2001;69:5151-6 pubmed..These results suggest that selection pressure on MSP2 occurred in tick salivary glands independent of the bovine immune response. ..
- Marra A, Lawson S, Asundi J, Brigham D, Hromockyj A. In vivo characterization of the psa genes from Streptococcus pneumoniae in multiple models of infection. Microbiology. 2002;148:1483-91 pubmed..In addition, these mutants were unable to grow in an implanted peritoneal chamber, but growth was restored by the addition of manganese to the chambers...
- Streblow D, Kreklywich C, Yin Q, De La Melena V, Corless C, Smith P, et al. Cytomegalovirus-mediated upregulation of chemokine expression correlates with the acceleration of chronic rejection in rat heart transplants. J Virol. 2003;77:2182-94 pubmed..These results suggest that CMV-induced acceleration of TVS involves the increased graft vascular infiltration of inflammatory cells through enhanced chemokine expression. ..
- Lin T, Zeng L, Liu Y, DeFea K, Schwartz M, Chien S, et al. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res. 2003;92:1296-304 pubmed..By enhancing the SREBP-mediated cholesterol metabolism, this unique mechanism may contribute to endothelial cell functions under flow. ..
- Sanderson M, Erickson S, Gough P, Garton K, Wille P, Raines E, et al. ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx. J Biol Chem. 2005;280:1826-37 pubmed..These results demonstrate, for the first time, activated pro-BTC shedding in response to extracellular calcium influx and APMA and provide evidence that ADAM10 mediates constitutive and activated pro-BTC shedding. ..
- Meller R, Cameron J, Torrey D, Clayton C, Ordonez A, Henshall D, et al. Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons. J Biol Chem. 2006;281:7429-36 pubmed..This suggests that the rapid degradation of cell death-promoting proteins by the ubiquitin-proteasome pathway may represent a novel therapeutic strategy to reduce cell damage following neuropathological insults, e.g. stroke. ..
- Nikolaidis N, Chalkia D, Watkins D, Barrow R, Snyder S, van Rossum D, et al. Ancient origin of the new developmental superfamily DANGER. PLoS ONE. 2007;2:e204 pubmed..Regulation of development may be a universal function of DANGER family members. This family provides a model system to investigate how rapid protein divergence contributes to morphological complexity. ..
- Shah V, Huang Y, Keshwara R, Ozment Skelton T, Williams D, Keshvara L. Beta-glucan activates microglia without inducing cytokine production in Dectin-1-dependent manner. J Immunol. 2008;180:2777-85 pubmed..Our results suggest that the Dectin-1 pathway may play an important role in antifungal immunity in the CNS. ..
- Huang W, Eum S, Andras I, Hennig B, Toborek M. PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities. FASEB J. 2009;23:1596-606 pubmed publisher..The present data indicate that down-regulation of MMP and proteasome activities constitutes a novel mechanism of PPAR-induced protections against HIV-induced disruption of brain endothelial cells. ..
- BIRKHOLZ D, Chou W, Phistry M, Britt S. rhomboid mediates specification of blue- and green-sensitive R8 photoreceptor cells in Drosophila. J Neurosci. 2009;29:2666-75 pubmed publisher..This suggests that rhomboid may function in R8 cells to activate Epidermal growth factor receptor signaling in R7 cells and promote their differentiation to a signaling competent state. ..
- Dey M, Baldys A, Sumter D, Gooz P, Luttrell L, Raymond J, et al. Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement. J Pharmacol Exp Ther. 2010;334:775-83 pubmed publisher..Our data indicate that ADAM17 and the EGFR may be potential novel therapeutic targets in diabetic nephropathy and other chronic kidney diseases. ..
- Hasan N, Corbin D, Hu C. Fusogenic pairings of vesicle-associated membrane proteins (VAMPs) and plasma membrane t-SNAREs--VAMP5 as the exception. PLoS ONE. 2010;5:e14238 pubmed publisher..These data indicate that VAMPs have differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs. ..
- Oka T, Schmitt A, Sudol M. Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP. Oncogene. 2012;31:128-34 pubmed publisher..As YAP is a potent oncogene, the identification and characterization of its regulators is important. AmotL1 and ZO-2 are two candidates that could be harnessed to control the oncogenic function of YAP. ..
- Uppalapati D, Ohta N, Zhang Y, Kawabata A, Pyle M, Becker K, et al. Identification and characterization of unique tumoricidal genes in rat umbilical cord matrix stem cells. Mol Pharm. 2011;8:1549-58 pubmed publisher..These results suggest that ADRP, SULF-1 and GPI act as tumor suppressor genes, and these genes might be involved in rat UCMSC-dependent growth attenuation of rat mammary tumors. ..
- Karunanithi S, Cullen P. The filamentous growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 transcriptional repressors in Saccharomyces cerevisiae. Genetics. 2012;192:869-87 pubmed publisher..Taken together, our findings provide the first regulatory link in yeast between components of the AMPK pathway and a MAPK pathway that controls cellular differentiation. ..
- Das S, Chen Q, Saucier J, Drescher B, Zong Y, Morgan S, et al. The Drosophila T-box transcription factor Midline functions within the Notch-Delta signaling pathway to specify sensory organ precursor cell fates and regulates cell survival within the eye imaginal disc. Mech Dev. 2013;130:577-601 pubmed publisher
- Spassieva S, Ji X, Liu Y, Gable K, Bielawski J, Dunn T, et al. Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency. Proc Natl Acad Sci U S A. 2016;113:5928-33 pubmed publisher..The strong association of LCB levels with neuronal survival both in vivo and in vitro suggests high-level accumulation of LCBs is a possible underlying cause of the CerS1 deficiency-induced neuronal death. ..
- Bastos R, Howard Z, Hiroyasu A, Goodman A. Host and Bacterial Factors Control Susceptibility of Drosophila melanogaster to Coxiella burnetii Infection. Infect Immun. 2017;85: pubmed publisher..Our work also demonstrates the usefulness of this BSL2 model to investigate both host and Coxiella components implicated in infection. ..
- Shay A, Diwakar B, Guan B, Narayan V, Urban J, Prabhu K. IL-4 up-regulates cyclooxygenase-1 expression in macrophages. J Biol Chem. 2017;292:14544-14555 pubmed publisher..In summary, these findings suggest a new paradigm where IL-4-dependent up-regulation of Cox-1 expression may play a key role in tissue homeostasis and wound healing during Th2-mediated immune responses, such as parasitic infections. ..
- Liu Y, Schiff M, Czymmek K, Tall czy Z, Levine B, Dinesh Kumar S. Autophagy regulates programmed cell death during the plant innate immune response. Cell. 2005;121:567-577 pubmed publisher..Thus, the evolutionarily conserved autophagy pathway plays an essential role in plant innate immunity and negatively regulates PCD...
- Qu C, Liang F, Hu W, Shen Z, Spicer S, Schulte B. Expression of CLC-K chloride channels in the rat cochlea. Hear Res. 2006;213:79-87 pubmed..These data support the hypothesis that both isoforms of ClC-K are co-expressed in some cell membranes and account for the preservation of hearing in the presence of a mutation in only one channel isoform. ..
- Lee C, Kim S, McClure B. A pollen protein, NaPCCP, that binds pistil arabinogalactan proteins also binds phosphatidylinositol 3-phosphate and associates with the pollen tube endomembrane system. Plant Physiol. 2009;149:791-802 pubmed publisher..Therefore, it could function in the transport of pistil ECM proteins in the pollen tube endomembrane system. ..
- Hall A, Nelson R, Rutishauser U. Binding properties of detergent-solubilized NCAM. J Cell Biol. 1990;110:817-24 pubmed..These results are consistent with the hypothesis that the major binding protein for NCAM is NCAM itself, and suggest that differences in polysialic acid content do not directly alter the properties of NCAM's homophilic binding site. ..
- Lillard J, Fetherston J, Pedersen L, Pendrak M, Perry R. Sequence and genetic analysis of the hemin storage (hms) system of Yersinia pestis. Gene. 1997;193:13-21 pubmed..5 kDa protein with a pI of 6.68. Hms- Y. pestis strain M23-2 transformed with the cloned hmsHFRS locus developed an Hms(c) phenotype (Hms+ at 26-37 degrees C) due to mutations in genes outside the pgm locus...
- Siegall C, Liggitt D, Chace D, Mixan B, Sugai J, Davidson T, et al. Characterization of vascular leak syndrome induced by the toxin component of Pseudomonas exotoxin-based immunotoxins and its potential inhibition with nonsteroidal anti-inflammatory drugs. Clin Cancer Res. 1997;3:339-45 pubmed..These results demonstrate that the toxin component of PE-based immunotoxins induce VLS and suggest agents for clinical management of the toxicity. ..
- Liu Z, Mukherjee A, Lutkenhaus J. Recruitment of ZipA to the division site by interaction with FtsZ. Mol Microbiol. 1999;31:1853-61 pubmed..These results are consistent with ZipA acting after Z ring formation, possibly to link the membrane to FtsZ filaments during invagination of the septum...
- Li X, Routt S, Xie Z, Cui X, Fang M, Kearns M, et al. Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Mol Biol Cell. 2000;11:1989-2005 pubmed..These findings expand the physiological repertoire of PITP function in yeast and provide the first in vivo demonstration of a role for specific PITPs in stimulating activation of PLD. ..
- Kingsley P, McGrath K, Maltby K, Koniski A, Ramchandran R, Palis J. Subtractive hybridization reveals tissue-specific expression of ahnak during embryonic development. Dev Growth Differ. 2001;43:133-43 pubmed..The potential functions of ahnak are discussed in light of these results. ..
- O Callaghan C, Cerwenka A, Willcox B, Lanier L, Bjorkman P. Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60. Immunity. 2001;15:201-11 pubmed..The distinct thermodynamic profiles provide insights into the different molecular mechanisms of the binding interactions. ..
- Zheng Z, Nafisi M, Tam A, Li H, Crowell D, Chary S, et al. Plasma membrane-associated ROP10 small GTPase is a specific negative regulator of abscisic acid responses in Arabidopsis. Plant Cell. 2002;14:2787-97 pubmed..These results suggest that ROP10 is a PM-localized signaling molecule that is involved specifically in the negative regulation of ABA signaling. ..
- Brunschwig E, Wilson K, Mack D, Dawson D, Lawrence E, Willson J, et al. PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer. Cancer Res. 2003;63:1568-75 pubmed
- Plasilova M, Risitano A, O Keefe C, Rodriguez A, Wlodarski M, Young N, et al. Shared and individual specificities of immunodominant cytotoxic T-cell clones in paroxysmal nocturnal hemoglobinuria as determined by molecular analysis. Exp Hematol. 2004;32:261-9 pubmed..Analysis of the CDR3 sequence pattern as a marker for expanded immunodominant clonotypes may have an application in the study of T-cell responses in PNH. ..
- Wu K, Khan S, Lakhe Reddy S, Jarad G, Mukherjee A, Obejero Paz C, et al. The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival. J Biol Chem. 2004;279:26280-6 pubmed
- Zhou H, Schulze R, Cox S, Saez C, Hu Z, Lutkenhaus J. Analysis of MinD mutations reveals residues required for MinE stimulation of the MinD ATPase and residues required for MinC interaction. J Bacteriol. 2005;187:629-38 pubmed..This mutant provides evidence that dimerization of MinD is sufficient for MinD to bind the membrane and recruit its partners. ..
- Lawler M, Larson D, Hinz A, Klein D, Brun Y. Dissection of functional domains of the polar localization factor PodJ in Caulobacter crescentus. Mol Microbiol. 2006;59:301-16 pubmed..Finally, we identify a cytoplasmic region of PodJ involved in targeting it to the flagellar pole, and a periplasmic region required for localization of PleC. ..
- Aslanukov A, Bhowmick R, Guruju M, Oswald J, Raz D, Bush R, et al. RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. PLoS Genet. 2006;2:e177 pubmed..Hence, RanBP2 and its partners emerge as critical modulators of neuronal HKI, glucose catabolism, energy homeostasis, and targets for metabolic, aging disorders and allied neuropathies. ..
- Kurusu M, Cording A, Taniguchi M, Menon K, Suzuki E, Zinn K. A screen of cell-surface molecules identifies leucine-rich repeat proteins as key mediators of synaptic target selection. Neuron. 2008;59:972-85 pubmed publisher..By manipulating gene expression in muscle 12, we showed that four LRR proteins participate in the selection of this muscle as the appropriate synaptic target for the RP5 motor neuron. ..
- Beck R, Padival M, Yeh D, Ralston J, Cooke K, Lowe J. The Notch ligands Jagged2, Delta1, and Delta4 induce differentiation and expansion of functional human NK cells from CD34+ cord blood hematopoietic progenitor cells. Biol Blood Marrow Transplant. 2009;15:1026-37 pubmed publisher..Thus, Notch ligands have differential ability to induce and expand immature, but functional, NK cells from CD34(+) HPCs. The use of Notch ligands to generate functional NK cells in vitro may be significant for cellular therapy purposes. ..
- Celver J, Sharma M, Kovoor A. D(2)-Dopamine receptors target regulator of G protein signaling 9-2 to detergent-resistant membrane fractions. J Neurochem. 2012;120:56-69 pubmed publisher..D(2)R-mediated targeting of RGS9-2 to DRM was blocked by the deletion of the RGS9-2 DEP domain or by a point mutation that abolishes the GTPase accelerating protein function of RGS9-2. ..
- Roth S, Rottach A, Lotz Havla A, Laux V, Muschaweckh A, Gersting S, et al. Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1? production. Nat Immunol. 2014;15:538-45 pubmed publisher..Our results define a cytosolic DNA-recognition pathway for inflammation and a physical and functional connection between a conserved DNA-damage sensor and the innate immune response to pathogens. ..
- Johnson C, Reid D, Parker J, Salter S, Knihtila R, Kuzmic P, et al. The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects. J Biol Chem. 2017;292:12981-12993 pubmed publisher..We present the crystal structure of N-Ras bound to a GTP analogue and interpret the kinetic data in terms of structural features specific for H-, K-, and N-Ras. ..
- Hong F, Liu B, Wu B, Morreall J, Roth B, Davies C, et al. CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response. Nat Struct Mol Biol. 2017;24:834-839 pubmed publisher..These findings demonstrate the critical roles of CNPY2 in ER stress and suggest that CNPY2 is a potential new therapeutic target for UPR-related diseases such as metabolic disorders, inflammation and cancer. ..
- Stojiljkovic I, Hwa V, de Saint Martin L, O Gaora P, Nassif X, Heffron F, et al. The Neisseria meningitidis haemoglobin receptor: its role in iron utilization and virulence. Mol Microbiol. 1995;15:531-41 pubmed..coli hemA aroB mutant on haemin-supplemented plates. The N. meningitidis hmbR mutant was attenuated in an infant rat model for meningococcal infection, indicating that haemoglobin utilization is important for N. meningitidis virulence...
- Zhen L, Jiang S, Feng L, Bright N, Peden A, Seymour A, et al. Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouse. Blood. 1999;94:146-55 pubmed..These and related experiments strongly suggest that the AP-3 complex regulates the biogenesis/function of organelles of platelets and other cells and that abrogation of expression of the AP-3 complex leads to platelet SPD. ..
- Neira M, Danilova V, Hellekant G, Azen E. A new gene (rmSTG) specific for taste buds is found by laser capture microdissection. Mamm Genome. 2001;12:60-6 pubmed publisher..The monkey, human, and mouse STG proteins contain potential O-glycosylation sites and tandem repeats inside a region showing approximately 50% similarity with prion proteins...
- Johnson A, Yabu J, Hanson S, Shah V, Zager R. Experimental glomerulopathy alters renal cortical cholesterol, SR-B1, ABCA1, and HMG CoA reductase expression. Am J Pathol. 2003;162:283-91 pubmed..However, HMGCR protein/mRNA increments can also result. These seem to reflect a maladaptive response, potentially contributing to a cell cholesterol overload state...
- Joseph S, Buchakjian M, Dubyak G. Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes. J Biol Chem. 2003;278:23331-42 pubmed..This colocalization may act to spatially restrict the actions of released ATP as a paracrine or autocrine mediator of cell-to-cell signaling. ..
- Wu S, Zhou T, Chiang C. Human mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors. Mol Cell Biol. 2003;23:6229-42 pubmed..Our data provides biochemical evidence that Mediator functions by facilitating activator-mediated recruitment of pol II and also promoter recognition by TBP, both of which can occur in the absence of TBP-associated factors in TFIID. ..
- Sedensky M, Siefker J, Koh J, Miller D, Morgan P. A stomatin and a degenerin interact in lipid rafts of the nervous system of Caenorhabditis elegans. Am J Physiol Cell Physiol. 2004;287:C468-74 pubmed..Each of these mutations alters anesthetic sensitivity in C. elegans. Because lipid rafts contain many of the putative targets of volatile anesthetics, they may represent a novel class of targets for volatile anesthetics. ..
- Martin M, Trimble M, Brun Y. Cell cycle-dependent abundance, stability and localization of FtsA and FtsQ in Caulobacter crescentus. Mol Microbiol. 2004;54:60-74 pubmed
- Ott P, Herzog B, Quast S, Hofstetter H, Boehm B, Tary Lehmann M, et al. Islet-cell antigen-reactive T cells show different expansion rates and Th1/Th2 differentiation in type 1 diabetic patients and healthy controls. Clin Immunol. 2005;115:102-14 pubmed..Using CFSE-dye-dilution, we demonstrate that naive T cells expand in vitro at a faster rate than memory cells, which might account for the differences in expansion rates between diabetic patients and controls. ..
- Schmidt M, Strenk M, Boyer M, Fritsch B. Importance of cell wall mannoproteins for septum formation in Saccharomyces cerevisiae. Yeast. 2005;22:715-23 pubmed..We discuss a model explaining the pleiotropic effects of impaired N-linked protein glycosylation on septation in S. cerevisiae. ..
- Kudlow B, Jameson S, Kennedy B. HIV protease inhibitors block adipocyte differentiation independently of lamin A/C. AIDS. 2005;19:1565-73 pubmed..Furthermore, lamin A/C plays a minimal role in the differentiation of 3T3-L1. ..
- Rothfield L, Taghbalout A, Shih Y. Spatial control of bacterial division-site placement. Nat Rev Microbiol. 2005;3:959-68 pubmed..Here, we review the latest findings on these two systems. ..
- Gorodeski G. Estrogen decrease in tight junctional resistance involves matrix-metalloproteinase-7-mediated remodeling of occludin. Endocrinology. 2007;148:218-31 pubmed..These mechanisms acting in concert could be important for regulation and control of estrogen modulation of paracellular permeability in vivo. ..
- Gubbels J, Belisle J, Onda M, Rancourt C, Migneault M, Ho M, et al. Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors. Mol Cancer. 2006;5:50 pubmed..The demonstration that N-linked glycans are essential for mediating mesothlein-MUC16 binding may lead to novel therapeutic targets to control the spread of ovarian carcinoma. ..
- Minaguchi T, Waite K, Eng C. Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein. Cancer Res. 2006;66:11677-82 pubmed..Collectively, our data present evidence of a novel crosstalk between the Ca(2+) signaling-mediated regulation of the cell cycle and MVP-mediated nuclear PTEN localization and function. ..
- Serasinghe M, Yoon Y. The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interaction. Exp Cell Res. 2008;314:3494-507 pubmed publisher..Our data suggest that oligomerization of hFis1 in the mitochondrial outer membrane plays a role in mitochondrial fission, potentially through participating in fission factor recruitment. ..
- Barrow S, Constable J, Clark E, El Sabeawy F, McAllister A, Washbourne P. Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis. Neural Dev. 2009;4:17 pubmed publisher..Our results suggest that axodendritic contact leads to rapid accumulation of Nlg1, recruitment of NMDARs co-transported with Nlg1 soon thereafter, followed by a slower, independent recruitment of PSD-95 to those nascent synapses. ..
- Sultana R, Banks W, Butterfield D. Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation o. J Neurosci Res. 2010;88:469-77 pubmed publisher..The data obtained from the current study suggest a possible involvement of these proteins in synaptic alterations, apoptosis and consequent decrements in learning and memory associated with the progression of MCI to AD. ..
- Fournier M, Paulson A, Pavelka N, Mosley A, Gaudenz K, Bradford W, et al. Delayed correlation of mRNA and protein expression in rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to rapamycin. Mol Cell Proteomics. 2010;9:271-84 pubmed publisher..A dynamic mRNA expression analysis of Deltaggc1 and wild-type cells treated with rapamycin revealed a key role for Ggc1p in the regulation of ribosome biogenesis and cell cycle progression under TOR control. ..
- Triozzi P, Aldrich W, Ponnazhagan S. Regulation of the activity of an adeno-associated virus vector cancer vaccine administered with synthetic Toll-like receptor agonists. Vaccine. 2010;28:7837-43 pubmed publisher..Suppressor mechanisms, including those mediated by myeloid cells, may negatively regulate the antitumor immune response. ..
- Rosenzweig H, Clowers J, Nunez G, Rosenbaum J, Davey M. Dectin-1 and NOD2 mediate cathepsin activation in zymosan-induced arthritis in mice. Inflamm Res. 2011;60:705-14 pubmed publisher..Together, Dectin-1 and NOD2 are critical, sentinel receptors in the arthritogenic effects of zymosan. Our data identify a novel role for NOD2 during inflammatory responses within joints. ..
- Lancaster T, Jefferson S, Korzick D. Local delivery of a PKCÎµ-activating peptide limits ischemia reperfusion injury in the aged female rat heart. Am J Physiol Regul Integr Comp Physiol. 2011;301:R1242-9 pubmed publisher..05). The mechanisms described here may represent important therapeutic candidates for the treatment of acute myocardial infarction in postmenopausal women and age-associated estradiol deficiency. ..