Genomes and Genes
Experts and Doctors on membrane proteins in United Kingdom
Locale: United Kingdom
Topic: membrane proteins
Publications397 found, 100 shown here
- Hunter P, Craddock C, Di Benedetto S, Roberts L, Frigerio L. Fluorescent reporter proteins for the tonoplast and the vacuolar lumen identify a single vacuolar compartment in Arabidopsis cells. Plant Physiol. 2007;145:1371-82 pubmed..Moreover, TIP isoform distribution is tissue and development specific, rather than organelle specific. ..
- Vladimirou E, Li M, Aldridge C, Frigerio L, Kirkilionis M, Robinson C. Diffusion of a membrane protein, Tat subunit Hcf106, is highly restricted within the chloroplast thylakoid network. FEBS Lett. 2009;583:3690-6 pubmed publisher..Integral membrane proteins within both the stromal and granal membranes are therefore highly constrained, possibly forming 'microdomains' that are sharply separated...
- Nuttall J, Motley A, Hettema E. Peroxisome biogenesis: recent advances. Curr Opin Cell Biol. 2011;23:421-6 pubmed publisher..In this minireview, we focus mainly on PMP biogenesis, and highlight recent advances in peroxisomal matrix protein import, fission and segregation in yeast...
- Bottanelli F, Foresti O, Hanton S, Denecke J. Vacuolar transport in tobacco leaf epidermis cells involves a single route for soluble cargo and multiple routes for membrane cargo. Plant Cell. 2011;23:3007-25 pubmed publisher..The results indicate that soluble vacuolar proteins follow a single route to vacuoles, while membrane spanning proteins may use at least three different transport mechanisms. ..
- Haining E, Yang J, Bailey R, Khan K, Collier R, Tsai S, et al. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. J Biol Chem. 2012;287:39753-65 pubmed publisher..This finding has therapeutic implications because focusing on specific TspanC8-ADAM10 complexes may allow cell type- and/or substrate-specific ADAM10 targeting...
- Blackwell J, Barton C, White J, Searle S, Baker A, Williams H, et al. Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism. Mol Med. 1995;1:194-205 pubmed..This analysis provides important resources to study the role of NRAMP in human disease. ..
- Balch S, McKnight A, Seldin M, Gordon S. Cloning of a novel C-type lectin expressed by murine macrophages. J Biol Chem. 1998;273:18656-64 pubmed..The mcl gene locus has been mapped between the genes for the interleukin-17 receptor and CD4 on mouse chromosome 6, the same chromosome as the mouse natural killer cell gene complex. ..
- Golby P, Davies S, Kelly D, Guest J, Andrews S. Identification and characterization of a two-component sensor-kinase and response-regulator system (DcuS-DcuR) controlling gene expression in response to C4-dicarboxylates in Escherichia coli. J Bacteriol. 1999;181:1238-48 pubmed..Although all three proteins have similar topologies and functions, and all are members of the two-component sensor-kinase family, their periplasmic domains appear to have evolved independently. ..
- Xu X, Laffert B, Screaton G, Kraft M, Wolf D, Kolanus W, et al. Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain. J Exp Med. 1999;189:1489-96 pubmed..Thus, our study may provide critical insights into the molecular mechanism whereby the HIV-1 accessory protein Nef contributes to the pathogenesis of HIV. ..
- Thackray P, Behravan J, Southworth T, Moir A. GerN, an antiporter homologue important in germination of Bacillus cereus endospores. J Bacteriol. 2001;183:476-82 pubmed publisher..Since germination in suboptimal concentrations of L-alanine shows a delay, additional germination transporters may be required for optimal response at low germinant concentrations...
- Walzl G, Matthews S, Kendall S, Gutierrez Ramos J, Coyle A, Openshaw P, et al. Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology. J Exp Med. 2001;193:785-92 pubmed..These results show that inhibition of T1/ST2 has a specific effect on virally induced Th2 responses and suggests that therapy targeted at this receptor might be of value in treating Th2-driven illness. ..
- Yoshimura T, Tomita T, Dixon M, Axon A, Robinson P, Crabtree J. ADAMs (a disintegrin and metalloproteinase) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa. J Infect Dis. 2002;185:332-40 pubmed..Chronic infection with H. pylori may result in persistent mucosal increases in members of the ADAMs family. ADAMs-mediated ectodomain shedding may have a role in gastric carcinogenesis. ..
- Varadi A, Tsuboi T, Rutter G. Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells. Mol Biol Cell. 2005;16:2670-80 pubmed..We conclude that MyoVa-driven movements of vesicles along the cortical actin network are essential for the terminal stages of regulated exocytosis in beta-cells. ..
- Bracale A, Cesca F, Neubrand V, Newsome T, Way M, Schiavo G. Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation. Mol Biol Cell. 2007;18:142-52 pubmed..Our results suggest that Kidins220/ARMS-positive carriers undergo a kinesin-1-dependent transport linked to neurotrophin action. ..
- Greaves J, Salaun C, Fukata Y, Fukata M, Chamberlain L. Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. J Biol Chem. 2008;283:25014-26 pubmed publisher..The coupling of CSP palmitoylation to Golgi membranes may thus be an important requirement for subsequent sorting. ..
- Kadekoppala M, O Donnell R, Grainger M, Crabb B, Holder A. Deletion of the Plasmodium falciparum merozoite surface protein 7 gene impairs parasite invasion of erythrocytes. Eukaryot Cell. 2008;7:2123-32 pubmed publisher..Despite this reduction in efficiency, D10DeltaMSP7 parasites did not show any obvious preference for alternate pathways of invasion. ..
- Irvine E, Drinkwater L, Radwanska K, Al Qassab H, Smith M, O Brien M, et al. Insulin receptor substrate 2 is a negative regulator of memory formation. Learn Mem. 2011;18:375-83 pubmed publisher..Overall, these results suggest that Irs2 acts as a negative regulator on memory formation by restricting dendritic spine generation. ..
- McDowell M, Johnson S, Deane J, Cheung M, Roehrich A, Blocker A, et al. Structural and functional studies on the N-terminal domain of the Shigella type III secretion protein MxiG. J Biol Chem. 2011;286:30606-14 pubmed publisher..Positioning of MxiG-N(6-112) within the EM density of the S. flexneri needle complex gives insight into the ambiguous stoichiometry of the T3SS, supporting models with 24 MxiG subunits in the inner membrane ring...
- Nie M, Balda M, Matter K. Stress- and Rho-activated ZO-1-associated nucleic acid binding protein binding to p21 mRNA mediates stabilization, translation, and cell survival. Proc Natl Acad Sci U S A. 2012;109:10897-902 pubmed publisher..We thus identify a unique type of stress and Rho signaling activated pathway that drives mRNA stabilization and translation and links the cellular stress response to p21 expression and cell survival...
- Banham A, Turley H, Pulford K, Gatter K, Mason D. The plasma cell associated antigen detectable by antibody VS38 is the p63 rough endoplasmic reticulum protein. J Clin Pathol. 1997;50:485-9 pubmed..While it is not exclusively expressed on plasma cells, the presence of p63 distinguishes plasma cells from other lymphoid cells because of their high secretory activity. ..
- Szekeres P, Muir A, Spinage L, Miller J, Butler S, Smith A, et al. Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. J Biol Chem. 2000;275:20247-50 pubmed..The discovery that neuromedin U is an endogenous agonist for FM3 will significantly aid the study of the full physiological role of this peptide. ..
- Gillespie C, Sherman D, Fleetwood Walker S, Cottrell D, Tait S, Garry E, et al. Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice. Neuron. 2000;26:523-31 pubmed
- Owens D, Watt F. Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion. Cancer Res. 2001;61:5248-54 pubmed..Our results demonstrate that the alpha3beta1 integrin can suppress malignant conversion, and that the mechanism may involve CD81. ..
- Paulsen M, Takada S, Youngson N, Benchaib M, Charlier C, Segers K, et al. Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region. Genome Res. 2001;11:2085-94 pubmed
- Allen S, Barrett C, Ray N, Robinson C. Essential cytoplasmic domains in the Escherichia coli TatC protein. J Biol Chem. 2002;277:10362-6 pubmed..The data point to two essential cytoplasmic domains on the TatC protein that are essential for export. ..
- Garry E, Moss A, Delaney A, O Neill F, Blakemore J, Bowen J, et al. Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice. Curr Biol. 2003;13:321-8 pubmed..Disruption of CaM kinase II docking to the NMDA receptor and activation may be responsible for the lack of neuropathic behavioral reflex sensitization in PSD-95 mutant mice. ..
- Torres I, Lopez Schier H, St Johnston D. A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila. Dev Cell. 2003;5:547-58 pubmed..The anterior-posterior axis is therefore established by a relay mechanism, which propagates polarity from one cyst to the next. ..
- Taylor P, Brown G, Herre J, Williams D, Willment J, Gordon S. The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages. J Immunol. 2004;172:1157-62 pubmed..These studies have identified SIGNR1 as a major MR for fungal and other pathogens present on specific subsets of Mphi. ..
- Hirst J, Miller S, Taylor M, von Mollard G, Robinson M. EpsinR is an adaptor for the SNARE protein Vti1b. Mol Biol Cell. 2004;15:5593-602 pubmed..These findings provide in vivo evidence that epsinR is an adaptor for vti1b, and they also show that CCV isolation can be used as an assay for adaptor function. ..
- Ley R, Hadfield K, Howes E, Cook S. Identification of a DEF-type docking domain for extracellular signal-regulated kinases 1/2 that directs phosphorylation and turnover of the BH3-only protein BimEL. J Biol Chem. 2005;280:17657-63 pubmed..Our results identify a new physiologically relevant functional motif in Bim(EL) that may account for the distinct biological properties of this splice variant. ..
- Hirst J, Borner G, Harbour M, Robinson M. The aftiphilin/p200/gamma-synergin complex. Mol Biol Cell. 2005;16:2554-65 pubmed
- Prescott G, Gorleku O, Greaves J, Chamberlain L. Palmitoylation of the synaptic vesicle fusion machinery. J Neurochem. 2009;110:1135-49 pubmed publisher..In this review, we discuss the mechanisms and dynamics of palmitoylation of these proteins and speculate on how palmitoylation might contribute to the regulation of synaptic vesicle fusion. ..
- Notari M, Hu Y, Koch S, Lu M, Ratnayaka I, Zhong S, et al. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification. Proc Natl Acad Sci U S A. 2011;108:16645-50 pubmed publisher..This study identifies iASPP as an inhibitor of senescence and a key player in controlling epithelial stratification. ..
- Wasmeier C, Hutton J. Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes. J Biol Chem. 1996;271:18161-70 pubmed..It is closely related to the diabetic autoantigen ICA512 (IA-2) (42% identity overall; 80% in the 260-amino acid PTP domain) and thus a potential target of autoimmunity in diabetes mellitus. ..
- Burton E, Tinsley J, Holzfeind P, Rodrigues N, Davies K. A second promoter provides an alternative target for therapeutic up-regulation of utrophin in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 1999;96:14025-30 pubmed..This promoter does not contain synaptic regulatory elements and might, therefore, be a more suitable target for pharmacological manipulation than the previously described promoter. ..
- Mullock B, Smith C, Ihrke G, Bright N, Lindsay M, Parkinson E, et al. Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion. Mol Biol Cell. 2000;11:3137-53 pubmed..Together, these data identify a SNARE complex that functions in the late endocytic system of animal cells. ..
- Ju M, Stevens L, Leadbitter E, Wray D. The Roles of N- and C-terminal determinants in the activation of the Kv2.1 potassium channel. J Biol Chem. 2003;278:12769-78 pubmed
- Beher D, Fricker M, Nadin A, Clarke E, Wrigley J, Li Y, et al. In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand. Biochemistry. 2003;42:8133-42 pubmed..This was also reflected by a co-distribution of both enzyme activities in subcellular fractions enriched for trans-Golgi network membranes. ..
- Robinson J, Johnson V, Rogers P, Houlston R, Maher E, Bishop D, et al. Evidence for an association between compound heterozygosity for germ line mutations in the hemochromatosis (HFE) gene and increased risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:1460-3 pubmed..TFR gene polymorphism was not an independent risk factor and did not modify the disease risk associated with HFE mutation. ..
- Toro C, Deakin J. NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder. Schizophr Res. 2005;80:323-30 pubmed..A down-regulation of PSD-95 in schizophrenia and bipolar disorder may also relate to disease mechanisms of psychosis. ..
- Kunji E, Chan K, Slotboom D, Floyd S, O Connor R, Monné M. Eukaryotic membrane protein overproduction in Lactococcus lactis. Curr Opin Biotechnol. 2005;16:546-51 pubmed..Recent advances in the development of the Lactococcus lactis expression system have opened the way for the high-throughput functional expression of eukaryotic membrane proteins. ..
- Thompson S, Wadhams G, Armitage J. The positioning of cytoplasmic protein clusters in bacteria. Proc Natl Acad Sci U S A. 2006;103:8209-14 pubmed..These data suggest that there is a mechanism involved in partitioning some cytoplasmic proteins upon cell division that is analogous to a mechanism seen for plasmid and chromosomal DNA. ..
- Farrell D, File T, Jenkins S. Prevalence and antibacterial susceptibility of mef(A)-positive macrolide-resistant Streptococcus pneumoniae over 4 years (2000 to 2004) of the PROTEKT US Study. J Clin Microbiol. 2007;45:290-3 pubmed..However, the ketolide antibacterial telithromycin consistently demonstrated in vitro activity against these isolates over the 4 years of the study (MIC90=0.5 to 1 microg/ml). ..
- Eames H, Saliba D, Krausgruber T, Lanfrancotti A, Ryzhakov G, Udalova I. KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages. Immunobiology. 2012;217:1315-24 pubmed publisher..Our study furthers an understanding of the complex molecular interactions between the TRIM and IRF protein families, and highlights a role of the inhibitory properties of KAP1 in association with IRF5-mediated gene expression. ..
- Margariti A, Li H, Chen T, Martin D, Vizcay Barrena G, Alam S, et al. XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. J Biol Chem. 2013;288:859-72 pubmed publisher..These results suggest that XBP1 mRNA splicing triggers an autophagic signal pathway through transcriptional regulation of BECLIN-1. ..
- Tate C, Henderson P. Membrane topology of the L-rhamnose-H+ transport protein (RhaT) from enterobacteria. J Biol Chem. 1993;268:26850-7 pubmed..However, the localization of the putative first hydrophilic loop and the NH2 terminus was not possible because the beta-lactamase fusions in this region were shown to be unreliable indicators of the topology of RhaT. ..
- Marsh S, Carter N, Dolce V, Iacobazzi V, Palmieri F. Chromosomal localization of the mitochondrial phosphate carrier gene PHC to 12q23. Genomics. 1995;29:814-5 pubmed
- Pearson A, Bruce K, Osborn A, Ritchie D, Strike P. Distribution of class II transposase and resolvase genes in soil bacteria and their association with mer genes. Appl Environ Microbiol. 1996;62:2961-5 pubmed..59:4024-4030, 1993) indicates the presence of hybrid transposons and provides evidence for extensive recombination, both between transposon genes and between transposon and mer genes, within these natural populations of bacteria. ..
- Griffiths G, Dubrez L, Morgan C, Jones N, Whitehouse J, Corfe B, et al. Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J Cell Biol. 1999;144:903-14 pubmed..This indicated that integration of cellular damage signals did not take place directly on the Bak protein. Release of proteins, including Bcl-xL, from Bak is suggested to be an important event in commitment to death. ..
- Flint M, Maidens C, Loomis Price L, Shotton C, Dubuisson J, Monk P, et al. Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81. J Virol. 1999;73:6235-44 pubmed..Finally, we demonstrate that ligation of CD81 by E2661 induced aggregation of lymphoid cells and inhibited B-cell proliferation, demonstrating that E2 interaction with CD81 can modulate cell function. ..
- Sherrier D, Prime T, Dupree P. Glycosylphosphatidylinositol-anchored cell-surface proteins from Arabidopsis. Electrophoresis. 1999;20:2027-35 pubmed..These findings support a model where GPI-anchored proteins are involved in the generation of specialized cell surfaces and extracellular signaling molecules. ..
- Swanton E, Bishop N, Woodman P. Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis. J Biol Chem. 1999;274:37583-90 pubmed..Caspase-dependent cleavage of rabaptin-5 generates two physically separated coiled coil-forming domains, the C-terminal of which retains the ability to bind the Rab5 exchange factor rabex-5. ..
- Plummer S, Hill K, Festing M, Steward W, Gescher A, Sharma R. Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents. Cancer Epidemiol Biomarkers Prev. 2001;10:1295-9 pubmed..Measurement of leukocyte COX-2 activity should be considered in clinical trials of other agents likely to inhibit this isozyme. ..
- Rickman C, Archer D, Meunier F, Craxton M, Fukuda M, Burgoyne R, et al. Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate. J Biol Chem. 2004;279:12574-9 pubmed..Our results shed new light on the functional importance of the conserved polybasic synaptotagmin motif, suggesting that synaptotagmin interacts with the t-SNARE dimer to up-regulate the probability of SNARE-mediated membrane fusion. ..
- Strange R, El Genidy N, Ramachandran S, Lovatt T, Fryer A, Smith A, et al. PTCH polymorphism is associated with the rate of increase in basal cell carcinoma numbers during follow-up: preliminary data on the influence of an exon 12-exon 23 haplotype. Environ Mol Mutagen. 2004;44:469-76 pubmed..The association between C1686-C3944 and BCCs/year remained significant (rate ratio = 0.44; 95% CI = 0.26-0.73 for two copies of the haplotype). The data show that allelic variation in PTCH contributes to the rate of development of BCC. ..
- Zhu J, Qiu Y, Figueroa D, Bandi V, Galczenski H, Hamada K, et al. Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosa. Am J Respir Cell Mol Biol. 2005;33:531-40 pubmed
- Collins R, Beis K, Clarke B, Ford R, Hulley M, Naismith J, et al. Periplasmic protein-protein contacts in the inner membrane protein Wzc form a tetrameric complex required for the assembly of Escherichia coli group 1 capsules. J Biol Chem. 2006;281:2144-50 pubmed..We propose that the crown is formed by protein-protein contacts from the four Wzc periplasmic domains, while each root represents an individual cytoplasmic tyrosine autokinase domain. ..
- Christian M, Kiskinis E, Debevec D, Leonardsson G, White R, Parker M. RIP140-targeted repression of gene expression in adipocytes. Mol Cell Biol. 2005;25:9383-91 pubmed..Therefore, reduction in the levels of RIP140 or prevention of its recruitment to nuclear receptors may provide novel mechanisms for the control of energy expenditure in adipose cells. ..
- Jacob T, Bogdanov Y, Magnus C, Saliba R, Kittler J, Haydon P, et al. Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors. J Neurosci. 2005;25:10469-78 pubmed
- Harrison H, Farnie G, Howell S, Rock R, Stylianou S, Brennan K, et al. Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res. 2010;70:709-18 pubmed publisher..Our findings suggest that Notch4-targeted therapies will be more effective than targeting Notch1 in suppressing breast cancer recurrence, as it is initiated by breast cancer stem cells. ..
- Gorleku O, Chamberlain L. Palmitoylation and testis-enriched expression of the cysteine-string protein beta isoform. Biochemistry. 2010;49:5308-13 pubmed publisher..Subsequent analysis of chimeric proteins reveals that regions upstream of the cysteine-string domains of CSPalpha and CSPbeta underlie this difference in palmitoylation efficiency between the two isoforms. ..
- Delint Ramirez I, FernÃ¡ndez E, BayÃ©s A, Kicsi E, Komiyama N, Grant S. In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93. J Neurosci. 2010;30:8162-70 pubmed publisher..These data show critical roles for scaffold proteins and their interactions with NMDA receptor subunits in organizing the differential expression in rafts and postsynaptic densities of synaptic signaling complexes. ..
- Odell A, Hollstein M, Ponnambalam S, Walker J. A VE-cadherin-PAR3-?-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)? in endothelial cells. Mol Biol Cell. 2012;23:1783-96 pubmed publisher..Thus a VE-cadherin-PAR3-?-catenin adhesion complex regulates cPLA(2)? recruitment to the Golgi apparatus, with functional consequences for vascular physiology. ..
- Ouberai M, Wang J, Swann M, Galvagnion C, Guilliams T, Dobson C, et al. ?-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling. J Biol Chem. 2013;288:20883-95 pubmed publisher..The ability of ?-Syn to sense lipid packing defects and to remodel membrane structure supports its proposed role in vesicle trafficking. ..
- Maddala R, Walters M, Brophy P, Bennett V, Rao P. Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics. Am J Physiol Cell Physiol. 2016;310:C115-26 pubmed publisher..Taken together, these observations reveal that AnkB is required for Prx membrane anchoring and for maintenance of lens fiber cell hexagonal geometry, membrane skeleton organization, and biomechanics. ..
- Borsch Haubold A, Pasquet S, Watson S. Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase. J Biol Chem. 1998;273:28766-72 pubmed..This is of particular relevance to studies on the regulation of cytosolic phospholipase A2 as these two MAPKs are capable of phosphorylating cytosolic phospholipase A2, thereby increasing its intrinsic activity. ..
- Chang C, Dietrich J, Harpur A, Lindquist J, Haude A, Loke Y, et al. Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. J Immunol. 1999;163:4651-4 pubmed..In addition, we identify KAP10 as being able to bind the adapter protein Grb2. Based on our data, we suggest that this molecule is involved in stimulation and costimulation in cells of both myeloid and lymphoid origin. ..
- Catsicas M, Mobbs P. GABAb receptors regulate chick retinal calcium waves. J Neurosci. 2001;21:897-910 pubmed..GABA(B) receptors are likely to be of key importance in regulating retinal development. ..
- Hill E, Van Der Kaay J, Downes C, Smythe E. The role of dynamin and its binding partners in coated pit invagination and scission. J Cell Biol. 2001;152:309-23 pubmed..The dramatic effects of the SH3 domain of endophilin led us to propose a model for the temporal order of addition of endophilin and its binding partner synaptojanin in the coated vesicle cycle. ..
- Jaju R, Fidler C, Haas O, Strickson A, Watkins F, Clark K, et al. A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia. Blood. 2001;98:1264-7 pubmed..The reciprocal transcript, NSD1-NUP98, was also detected by reverse transcriptase--polymerase chain reaction. This is the first report in which the novel gene NSD1 has been implicated in human malignancy. (Blood. 2001;98:1264-1267) ..
- Smith V, Alcami A. Inhibition of interferons by ectromelia virus. J Virol. 2002;76:1124-34 pubmed..These findings will facilitate future studies of the role of viral anti-IFN strategies in mousepox pathogenesis. Their significance in the light of earlier data on the role of IFNs in mousepox is discussed...
- Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley J, et al. The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. J Biol Chem. 2002;277:15221-4 pubmed..These data also suggest that the structural determinants involved in PDZ interactions are more complex than originally envisaged. ..
- Benvenuti S, Cramer R, Quinn C, Bruce J, Zvelebil M, Corless S, et al. Differential proteome analysis of replicative senescence in rat embryo fibroblasts. Mol Cell Proteomics. 2002;1:280-92 pubmed..The majority of these candidate proteins were unrecognized previously in replicative senescence. They are now implicated in a new role. ..
- Clayton A, Holland E, Pang L, Knox A. Interleukin-1beta differentially regulates beta2 adrenoreceptor and prostaglandin E2-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells. Role of receptor changes, adenylyl cyclase, cyclo-oxygenase 2, and protein kin. J Biol Chem. 2005;280:23451-63 pubmed..These findings have important implications for diseases involving inflammation and abnormal ion flux such as cystic fibrosis. ..
- Mulvihill D, Edwards S, Hyams J. A critical role for the type V myosin, Myo52, in septum deposition and cell fission during cytokinesis in Schizosaccharomyces pombe. Cell Motil Cytoskeleton. 2006;63:149-61 pubmed..On the commencement of septum formation, Myo52 transports Bgs1 to the cell equator, thus ensuring the accurate deposition of beta-1,3-glucan at the leading edge of the primary septum. ..
- Sidibe A, Yin X, Tarelli E, Xiao Q, Zampetaki A, Xu Q, et al. Integrated membrane protein analysis of mature and embryonic stem cell-derived smooth muscle cells using a novel combination of CyDye/biotin labeling. Mol Cell Proteomics. 2007;6:1788-97 pubmed
- Mullen L, Nair S, Ward J, Rycroft A, Williams R, Robertson G, et al. Novel adhesin from Pasteurella multocida that binds to the integrin-binding fibronectin FnIII9-10 repeats. Infect Immun. 2008;76:1093-104 pubmed..These results support the hypothesis that the PM1665 protein is a member of a new family of fibronectin binding adhesins that are important in the adhesion of P. multocida to fibronectin. ..
- Dukes J, Fish L, Richardson J, Blaikley E, Burns S, Caunt C, et al. Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells. Mol Biol Cell. 2011;22:3192-205 pubmed publisher..Thus, in mammalian epithelial cells, ESCRT function is required for claudin-1 trafficking and for epithelial cell polarity, supporting the hypothesis that ESCRT proteins function as tumor suppressors. ..
- Lovo E, Zhang M, Wang L, Ashton Rickardt P. Serine protease inhibitor 6 is required to protect dendritic cells from the kiss of death. J Immunol. 2012;188:1057-63 pubmed publisher..We conclude that the negative regulation of DC priming of CD8 T lymphocyte immunity by CTL killing is mitigated by the physiological inhibition of GrB by Spi6. ..
- Zawadzki P, May P, Baker R, Pinkney J, Kapanidis A, Sherratt D, et al. Conformational transitions during FtsK translocase activation of individual XerCD-dif recombination complexes. Proc Natl Acad Sci U S A. 2013;110:17302-7 pubmed publisher..These observations, along with the calculated intermediate lifetimes, inform the reaction mechanism, which plays a key role in chromosome unlinking in most bacteria with circular chromosomes. ..
- Schulze R, Komar J, Botte M, Allen W, Whitehouse S, Gold V, et al. Membrane protein insertion and proton-motive-force-dependent secretion through the bacterial holo-translocon SecYEG-SecDF-YajC-YidC. Proc Natl Acad Sci U S A. 2014;111:4844-9 pubmed publisher..A similar modularity may also be exploited for the translocation or insertion of a wide range of substrates across and into the endoplasmic reticular and mitochondrial membranes of eukaryotes. ..
- McCormack S, Li D, Kim Y, Lee J, Kim S, Rapaport R, et al. Digenic Inheritance of PROKR2 and WDR11 Mutations in Pituitary Stalk Interruption Syndrome. J Clin Endocrinol Metab. 2017;102:2501-2507 pubmed publisher..In cases of hypopituitarism in which there is incomplete segregation of a monogenic genotype with the phenotype, the possibility that a second genetic locus is involved should be considered. ..