Genomes and Genes
Experts and Doctors on membrane proteins in Switzerland
Topic: membrane proteins
Publications207 found, 100 shown here
- von Kienlin M, Künnecke B, Metzger F, Steiner G, Richards J, Ozmen L, et al. Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span. Neurobiol Dis. 2005;18:32-9 pubmed..These noninvasive biomarkers can be exploited in preclinical pharmaceutical research to cope with the high variability in transgenic animal models and to enhance the power of drug efficacy studies. ..
- van Rijnsoever C, Sidler C, Fritschy J. Internalized GABA-receptor subunits are transferred to an intracellular pool associated with the postsynaptic density. Eur J Neurosci. 2005;21:327-38 pubmed..Furthermore, the close association of gephyrin with internalized GABAA receptors suggests a role in intracellular receptor trafficking. ..
- Guillemot L, Citi S. Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA. Mol Biol Cell. 2006;17:3569-77 pubmed..These results provide novel insights about the mechanisms of cingulin function and the signaling pathways controlling claudin-2 expression in MDCK cells. ..
- Olivari S, Molinari M. Glycoprotein folding and the role of EDEM1, EDEM2 and EDEM3 in degradation of folding-defective glycoproteins. FEBS Lett. 2007;581:3658-64 pubmed..This review describes current knowledge about mechanisms regulating folding and disposal of glycoproteins. ..
- Nikonenko I, Boda B, Steen S, Knott G, Welker E, Muller D. PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling. J Cell Biol. 2008;183:1115-27 pubmed publisher..NOS blockade also reduced spine and synapse density in developing hippocampal cultures. These results indicate that the postsynaptic site, through an NOS-PSD-95 interaction and NO signaling, promotes synapse formation with nearby axons. ..
- Andres C, Agne B, Kessler F. The TOC complex: preprotein gateway to the chloroplast. Biochim Biophys Acta. 2010;1803:715-23 pubmed publisher..In this review we will describe the current state of knowledge regarding the composition and function of the TOC complex. ..
- Belibasakis G, Emingil G, Saygan B, Turkoglu O, Atilla G, Bostanci N. Gene expression of transcription factor NFATc1 in periodontal diseases. APMIS. 2011;119:167-72 pubmed publisher..The increased expression of NFATc1 in periodontitis denotes a role for this transcription factor in the pathogenesis of the disease. ..
- Brokopp C, Schoenauer R, Richards P, Bauer S, Lohmann C, Emmert M, et al. Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata. Eur Heart J. 2011;32:2713-22 pubmed publisher..Fibroblast activation protein expression in HASMC is induced by macrophage-derived TNF?. Fibroblast activation protein associates with thin-cap human coronary fibroatheromata and contributes to type I collagen breakdown in fibrous caps. ..
- Breitling J, Aebi M. N-linked protein glycosylation in the endoplasmic reticulum. Cold Spring Harb Perspect Biol. 2013;5:a013359 pubmed publisher..This article focuses on the processes in the ER. Based on the highly conserved nature of this pathway we concentrate on the mechanisms in the eukaryotic model organism Saccharomyces cerevisiae. ..
- Huang C, Olieric V, Ma P, Howe N, Vogeley L, Liu X, et al. In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures. Acta Crystallogr D Struct Biol. 2016;72:93-112 pubmed publisher..Insulin and lysozyme were used as test soluble proteins. The quality of the data that can be generated by this method was attested to by performing sulfur and bromine SAD phasing with two of the test proteins. ..
- Bueler H, Fischer M, Lang Y, Bluethmann H, Lipp H, DeArmond S, et al. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature. 1992;356:577-82 pubmed..It is now feasible to determine whether mice devoid of PrPC can propagate prions and are susceptible to scrapie pathogenesis. ..
- Chretien I, Robert J, Marcuz A, Garcia Sanz J, Courtet M, Du Pasquier L. CTX, a novel molecule specifically expressed on the surface of cortical thymocytes in Xenopus. Eur J Immunol. 1996;26:780-91 pubmed..Based on its unique tissue distribution, the variability of its V region and the motif of its cytoplasmic domain, CTX is a candidate for a new type of specific molecule involved in thymocyte selection. ..
- Antonsson B, Lutjens R, Di Paolo G, Kassel D, Allet B, Bernard A, et al. Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10. Protein Expr Purif. 1997;9:363-71 pubmed..Our data suggest that SCG10 is a phosphoprotein which might be involved in signal transduction in neurons. ..
- Klopfenstein D, Kappeler F, Hauri H. A novel direct interaction of endoplasmic reticulum with microtubules. EMBO J. 1998;17:6168-77 pubmed..p63 is the first identified integral membrane protein that can link a membrane organelle directly to microtubules. By doing so, it may contribute to the positioning of the ER along microtubules. ..
- Klopfenstein D, Klumperman J, Lustig A, Kammerer R, Oorschot V, Hauri H. Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment. J Cell Biol. 2001;153:1287-300 pubmed..Concentration of CLIMP-63 into patches may enhance microtubule binding on the cytosolic side and contribute to ER morphology by the formation of a protein scaffold in the lumen of the ER. ..
- Rothenberger S, Rousseaux M, Knecht H, Bender F, Legler D, Bron C. Association of the Epstein-Barr virus latent membrane protein 1 with lipid rafts is mediated through its N-terminal region. Cell Mol Life Sci. 2002;59:171-80 pubmed..Moreover, Ndelta25 inhibited WT LMP1-mediated induction of the transcription factors NF-kappaB and AP-1. Morphological data indicate that Ndelta25 hampers WT LMP1 plasma membrane localization, thus blocking LMP1 function. ..
- Huh K, Fuhrer C. Clustering of nicotinic acetylcholine receptors: from the neuromuscular junction to interneuronal synapses. Mol Neurobiol. 2002;25:79-112 pubmed..This review summarizes the current knowledge about formation and stabilization of the postsynaptic apparatus at the neuromuscular junction and extends this to explore the synaptic structures of interneuronal cholinergic synapses. ..
- Grauschopf U, Fritz A, Glockshuber R. Mechanism of the electron transfer catalyst DsbB from Escherichia coli. EMBO J. 2003;22:3503-13 pubmed..This demonstrates that the high catalytic efficiency of DsbB results from the extreme intrinsic oxidative force of the enzyme. ..
- Wodnar Filipowicz A. Flt3 ligand: role in control of hematopoietic and immune functions of the bone marrow. News Physiol Sci. 2003;18:247-51 pubmed..Potent effects of flt3 ligand on HSCs and the development of the immune system have generated much interest in the clinical application of this cytokine in stem cell transplantation and cancer immunotherapy. ..
- Schaerli P, Britschgi M, Keller M, Steiner U, Steinmann L, Moser B, et al. Characterization of human T cells that regulate neutrophilic skin inflammation. J Immunol. 2004;173:2151-8 pubmed..This mechanism may be relevant for other T cell-mediated diseases with a neutrophilic inflammation such as Behçet's disease and pustular psoriasis. ..
- Ingold K, Zumsteg A, Tardivel A, Huard B, Steiner Q, Cachero T, et al. Identification of proteoglycans as the APRIL-specific binding partners. J Exp Med. 2005;201:1375-83 pubmed
- Nyfeler B, Reiterer V, Wendeler M, Stefan E, Zhang B, Michnick S, et al. Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin. J Cell Biol. 2008;180:705-12 pubmed publisher..The results reveal ERGIC-53 to be an intracellular transport receptor of alpha1-AT and provide direct evidence for active receptor-mediated ER export of a soluble secretory protein in higher eukaryotes. ..
- Schäfer N, Luhmann U, Feil S, Berger W. Differential gene expression in Ndph-knockout mice in retinal development. Invest Ophthalmol Vis Sci. 2009;50:906-16 pubmed publisher..In particular, ectopic expression of Plvap is consistent with hallmark disease symptoms in mice and humans. ..
- Ramming T, Appenzeller Herzog C. The physiological functions of mammalian endoplasmic oxidoreductin 1: on disulfides and more. Antioxid Redox Signal. 2012;16:1109-18 pubmed publisher..The conserved, ER-resident endoplasmic oxidoreductin 1 (Ero1) sulfhydryl oxidases that reduce molecular oxygen to generate an active-site disulfide represent one of these pathways. In mammals, two family members exist, Ero1? and Ero1?...
- Ihssen J, Kowarik M, Wiesli L, Reiss R, Wacker M, Thöny Meyer L. Structural insights from random mutagenesis of Campylobacter jejuni oligosaccharyltransferase PglB. BMC Biotechnol. 2012;12:67 pubmed publisher..coli system. ..
- Kocik L, Junne T, Spiess M. Orientation of internal signal-anchor sequences at the Sec61 translocon. J Mol Biol. 2012;424:368-78 pubmed publisher..The results indicate a mechanistic difference in the insertion process of N-terminal and internal signal sequences. ..
- Pfreundschuh M, Hensen U, Muller D. Quantitative imaging of the electrostatic field and potential generated by a transmembrane protein pore at subnanometer resolution. Nano Lett. 2013;13:5585-93 pubmed publisher..These experimental results establish FD-based AFM as a unique tool to image biological systems to subnanometer resolution and to quantify their electrostatic properties. ..
- Greber U, Gastaldelli M. Junctional gating: the achilles' heel of epithelial cells in pathogen infection. Cell Host Microbe. 2007;2:143-6 pubmed..A distinctive endocytic mechanism opens the junctions and gates infectious virus entry. ..
- Guillas I, Jiang J, Vionnet C, Roubaty C, Uldry D, Chuard R, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003;278:37083-91 pubmed..CLN8, another human LAG1 homologue implicated in ceroid lipofuscinosis, could not restore viability to lag1delta lac1delta yeast mutants. ..
- Fraering P, Imhof I, Meyer U, Strub J, Van Dorsselaer A, Vionnet C, et al. The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p. Mol Biol Cell. 2001;12:3295-306 pubmed publisher..When GPI precursor proteins or GPI lipids are depleted, the transamidase complex remains intact...
- Herwig L, Blum Y, Krudewig A, Ellertsdottir E, Lenard A, Belting H, et al. Distinct cellular mechanisms of blood vessel fusion in the zebrafish embryo. Curr Biol. 2011;21:1942-8 pubmed publisher..Here, the invaginating inner cell membrane undergoes concomitant apicobasal polarization and the vascular lumen is formed by the extension of a transcellular lumen through the EC, which forms a unicellular or seamless tube...
- Helenius J, Aebi M. Transmembrane movement of dolichol linked carbohydrates during N-glycoprotein biosynthesis in the endoplasmic reticulum. Semin Cell Dev Biol. 2002;13:171-8 pubmed..The transfer of the substrates and intermediates depend on specific translocators, i.e. so called flippases...
- Beermann F, Orlow S, Boissy R, Schmidt A, Boissy Y, Lamoreux M. Misrouting of tyrosinase with a truncated cytoplasmic tail as a result of the murine platinum (cp) mutation. Exp Eye Res. 1995;61:599-607 pubmed..Our results demonstrate misrouting of a mutant tyrosinase lacking its cytoplasmic tail, providing an explanation for the severe effect of this mutation on ocular and cutaneous pigmentation. ..
- Thaminy S, Auerbach D, Arnoldo A, Stagljar I. Identification of novel ErbB3-interacting factors using the split-ubiquitin membrane yeast two-hybrid system. Genome Res. 2003;13:1744-53 pubmed..We expect the split-ubiquitin membrane YTH technology to be valuable for the identification of potential interacting partners of integral membrane proteins from many model organisms. ..
- Pfeiffer F, Schäfer J, Lyck R, Makrides V, Brunner S, Schaeren Wiemers N, et al. Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol. 2011;122:601-14 pubmed publisher..Our observations suggest that stabilizing BBB barrier function by therapeutic targeting of TJs may be beneficial in treating MS, especially when anti-inflammatory treatments have failed...
- Aurrand Lions M, Duncan L, Ballestrem C, Imhof B. JAM-2, a novel immunoglobulin superfamily molecule, expressed by endothelial and lymphatic cells. J Biol Chem. 2001;276:2733-41 pubmed..Taken together, our results suggest that JAM-2 is a novel vascular molecule, which participates in interendothelial junctional complexes...
- Desplantez T, Marics I, Jarry Guichard T, Veteikis R, Briand J, Weingart R, et al. Characterization of zebrafish Cx43.4 connexin and its channels. Exp Physiol. 2003;88:681-90 pubmed..The single channel currents yielded two prominent levels attributable to a main conductance state (gamma(j,main) = 33.2 +/- 1.5 pS) and a residual conductance state (gamma(j,residual) = 11.9 +/- 0.6 pS). ..
- Berset T, Hoier E, Battu G, Canevascini S, Hajnal A. Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development. Science. 2001;291:1055-8 pubmed..LIN-12/NOTCH up-regulates lip-1 transcription in P5.p and P7.p where LIP-1 inactivates the MAP kinase to inhibit primary fate specification. LIP-1 thus links the two signaling pathways to generate a pattern. ..
- Wilson A, MacDonald H, Radtke F. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J Exp Med. 2001;194:1003-12 pubmed
- Flahaut M, Rossier B, Firsov D. Respective roles of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMP) in cell surface expression of CRLR/RAMP heterodimeric receptors. J Biol Chem. 2002;277:14731-7 pubmed..Our data argue against a chaperone function for RAMP and identify the role of N-glycosylation in targeting these molecules to the cell surface. ..
- Riera C, Vogel H, Simon S, le Coutre J. Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. Am J Physiol Regul Integr Comp Physiol. 2007;293:R626-34 pubmed..In summary, our results identify a novel group of compounds that activate TRPV1 and, consequently, provide a molecular mechanism that may account for off tastes of sweeteners and metallic tasting salts. ..
- Froquet R, Cherix N, Birke R, Benghezal M, Cameroni E, Letourneur F, et al. Control of cellular physiology by TM9 proteins in yeast and Dictyostelium. J Biol Chem. 2008;283:6764-72 pubmed publisher..These results suggest that in both yeast and amoebae, TM9 proteins participate in the control of specific cellular functions in response to changing nutrient conditions. ..
- Mandicourt G, Iden S, Ebnet K, Aurrand Lions M, Imhof B. JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration. J Biol Chem. 2007;282:1830-7 pubmed..These results highlight an unexpected function for JAM-C in controlling epithelial cell conversion from a static, polarized state to a pro-migratory phenotype. ..
- Antonsson B, Kassel D, Di Paolo G, Lutjens R, Riederer B, Grenningloh G. Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity. J Biol Chem. 1998;273:8439-46 pubmed
- Galan J, Wiederkehr A, Seol J, Haguenauer Tsapis R, Deshaies R, Riezman H, et al. Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast. Mol Cell Biol. 2001;21:3105-17 pubmed..Importantly, Skp1p was the only major partner that copurified with Rcy1p. Our results thus suggest that a complex composed of Rcy1p and Skp1p but not other SCF components may play a direct role in recycling of internalized proteins. ..
- Rintelen F, Hafen E, Nairz K. The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER. Development. 2003;130:3479-90 pubmed..In addition, DMKP3 function appears to be required in surrounding non-neuronal cells for ommatidial patterning and photoreceptor differentiation. ..
- Lütolf S, Radtke F, Aguet M, Suter U, Taylor V. Notch1 is required for neuronal and glial differentiation in the cerebellum. Development. 2002;129:373-85 pubmed..We have also analyzed the effects of Notch1 ablation on gliogenesis in vivo. Our results show that Notch1 is required for both neuron and glia formation and modulates the onset of neurogenesis within the cerebellar neuroepithelium. ..
- Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier P. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002;16:2283-96 pubmed..Thus, in contrast to most other family members, OATP-F has a more selective substrate preference and may play an important role in the disposition of thyroid hormones in brain and testis. ..
- Prinz M, Montrasio F, Klein M, Schwarz P, Priller J, Odermatt B, et al. Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells. Proc Natl Acad Sci U S A. 2002;99:919-24 pubmed..Macrophage subsets are plausible candidates for lymphoreticular prion pathogenesis and neuroinvasion in the absence of FDCs, and may represent a novel target for postexposure prophylaxis. ..
- Lowin Kropf B, Kunz B, Schneider P, Held W. A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors. Eur J Immunol. 2002;32:773-82 pubmed..NK cells may acquire Ly49 receptors until they generate sufficient inhibitory signals to balance their activation levels. Such a process would ensure the induction of NK cell self-tolerance. ..
- Hagedorn M, Soldati T. Flotillin and RacH modulate the intracellular immunity of Dictyostelium to Mycobacterium marinum infection. Cell Microbiol. 2007;9:2716-33 pubmed publisher..marinum. Conversely, the absence of the small GTPase RacH renders the host more susceptible to M. marinum proliferation but inhibits its cell-to-cell spreading...
- Cosson P, Démollière C, Hennecke S, Duden R, Letourneur F. Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval. EMBO J. 1996;15:1792-8 pubmed..Both proteins show significant homology to clathrin adaptor subunits. These results emphasize the role of coatomer in retrieval of dilysine-tagged proteins back to the ER, and the similarity between clathrin and coatomer coats. ..
- Burda P, Borsig L, de Rijk van Andel J, Wevers R, Jaeken J, Carchon H, et al. A novel carbohydrate-deficient glycoprotein syndrome characterized by a deficiency in glucosylation of the dolichol-linked oligosaccharide. J Clin Invest. 1998;102:647-52 pubmed..Accordingly, the efficiency of N-linked protein glycosylation was found to be reduced in fibroblasts from these patients...
- Narberhaus F, Urech C, Hennecke H. Characterization of the Bradyrhizobium japonicum ftsH gene and its product. J Bacteriol. 1999;181:7394-7 pubmed..The expression of B. japonicum ftsH in an ftsH-negative Escherichia coli strain significantly enhanced the fitness of this mutant and reduced the steady-state level of sigma(32). ..
- Kunz B, Held W. Positive and negative roles of the trans-acting T cell factor-1 for the acquisition of distinct Ly-49 MHC class I receptors by NK cells. J Immunol. 2001;166:6181-7 pubmed..These findings reveal an important role of TCF-1 for the formation of the NK cell receptor repertoire. ..
- Genoud S, Lappe Siefke C, Goebbels S, Radtke F, Aguet M, Scherer S, et al. Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol. 2002;158:709-18 pubmed..These findings establish a widespread function of Notch1 in the late steps of mammalian OPC development in vivo. ..
- Végh M, Basler K. A genetic screen for hedgehog targets involved in the maintenance of the Drosophila anteroposterior compartment boundary. Genetics. 2003;163:1427-38 pubmed..Among these, we identified a class of patched (ptc) alleles exhibiting a novel phenotype. These results demonstrate the value of our setup in the identification of genes involved in distinct wing-patterning processes. ..
- Le Fourn V, Gaplovska Kysela K, Guhl B, Santimaria R, Zuber C, Roth J. Basal autophagy is involved in the degradation of the ERAD component EDEM1. Cell Mol Life Sci. 2009;66:1434-45 pubmed publisher..Our studies demonstrate that endogenous EDEM1 in cells not stressed by the expression of a transgenic misfolded protein reaches the cytosol and is degraded by basal autophagy. ..
- Takahashi Y, Goldschmidt Clermont M, Soen S, Franzen L, Rochaix J. Directed chloroplast transformation in Chlamydomonas reinhardtii: insertional inactivation of the psaC gene encoding the iron sulfur protein destabilizes photosystem I. EMBO J. 1991;10:2033-40 pubmed..The present study suggests that any chloroplast gene encoding a component of the photosynthetic apparatus can be disrupted in C. reinhardtii using the strategy described. ..
- Schultz Thater E, Noppen C, Gudat F, Dürmüller U, Zajac P, Kocher T, et al. NY-ESO-1 tumour associated antigen is a cytoplasmic protein detectable by specific monoclonal antibodies in cell lines and clinical specimens. Br J Cancer. 2000;83:204-8 pubmed..These data suggest that active specific immunotherapies targeting NY-ESO-1, alone or in combination with other TAA could be of high clinical relevance in sizeable subgroups of melanoma patients. ..
- Kunz J, Schneider U, Howald I, Schmidt A, Hall M. HEAT repeats mediate plasma membrane localization of Tor2p in yeast. J Biol Chem. 2000;275:37011-20 pubmed..Our studies therefore place Tor proteins at the site of action of their known downstream effectors and suggest that they may be part of a multiprotein complex. ..
- D Atri F, Citi S. Molecular complexity of vertebrate tight junctions (Review). Mol Membr Biol. 2002;19:103-12 pubmed..How these molecules functionally interact to provide TJ with their functions, and what roles these molecules play in control of cell growth and differentiation is a fundamental problem in cell biology. ..
- Rolink A, Balciunaite G, Demolière C, Ceredig R. The potential involvement of Notch signaling in NK cell development. Immunol Lett. 2006;107:50-7 pubmed..The potential involvement of Notch signaling in the generation of the NK cell repertoire in vivo is discussed. ..
- Kronidou N, Oppliger W, Bolliger L, Hannavy K, Glick B, Schatz G, et al. Dynamic interaction between Isp45 and mitochondrial hsp70 in the protein import system of the yeast mitochondrial inner membrane. Proc Natl Acad Sci U S A. 1994;91:12818-22 pubmed..This arrangement is reminiscent of the protein transport systems of the yeast endoplasmic reticulum and the bacterial plasma membrane. ..
- Steinhoff U, Muller U, Schertler A, Hengartner H, Aguet M, Zinkernagel R. Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice. J Virol. 1995;69:2153-8 pubmed
- Koehler C, Jarosch E, Tokatlidis K, Schmid K, Schweyen R, Schatz G. Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. Science. 1998;279:369-73 pubmed..Neither protein was required for protein import into the other mitochondrial compartments. Both proteins may function as intermembrane space chaperones for the highly insoluble carrier proteins. ..
- Rossi J, Bischoff M, Wada A, Berger B chi B. MsrR, a putative cell envelope-associated element involved in Staphylococcus aureus sarA attenuation. Antimicrob Agents Chemother. 2003;47:2558-64 pubmed..These observations suggest that MsrR is a new component involved in sarA attenuation and the regulatory network controlling virulence gene expression in S. aureus...
- Besseyrias V, Fiorini E, Strobl L, Zimber Strobl U, Dumortier A, Koch U, et al. Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J Exp Med. 2007;204:331-43 pubmed..Collectively, our results establish a hierarchy of Notch-Delta interactions in which N1-DL4 exhibits the greatest capacity to induce and support T cell development. ..
- Wilson A, de Villartay J, MacDonald H. T cell receptor delta gene rearrangement and T early alpha (TEA) expression in immature alpha beta lineage thymocytes: implications for alpha beta/gamma delta lineage commitment. Immunity. 1996;4:37-45 pubmed..Finally, VDJ delta rearrangements in immature alpha beta cells appear to be random, supporting models in which alpha beta lineage commitment is determined independently of the rearrangement status at the TCR delta locus. ..
- Reiss G, te Heesen S, Gilmore R, Zufferey R, Aebi M. A specific screen for oligosaccharyltransferase mutations identifies the 9 kDa OST5 protein required for optimal activity in vivo and in vitro. EMBO J. 1997;16:1164-72 pubmed..A strong genetic interaction with a stt3 mutation implies a role in complex assembly. ..
- Maillard I, Launois P, Xenarios I, Louis J, Acha Orbea H, Diggelmann H. Immune response to mouse mammary tumor virus in mice lacking the alpha/beta interferon or the gamma interferon receptor. J Virol. 1998;72:2638-46 pubmed..This was associated with lower titers of virus-specific antibodies in serum early after infection, although efficient titers were reached later. ..
- Mueller C, Corazza N, Trachsel Løseth S, Eugster H, Bühler Jungo M, Brunner T, et al. Noncleavable transmembrane mouse tumor necrosis factor-alpha (TNFalpha) mediates effects distinct from those of wild-type TNFalpha in vitro and in vivo. J Biol Chem. 1999;274:38112-8 pubmed..This indicates that transmembrane TNFalpha may greatly affect the course of a cellular immune responses in vivo and exerts quantitatively and qualitatively distinct functions from secreted TNFalpha in vitro and in vivo. ..
- Wiederkehr A, Avaro S, Prescianotto Baschong C, Haguenauer Tsapis R, Riezman H. The F-box protein Rcy1p is involved in endocytic membrane traffic and recycling out of an early endosome in Saccharomyces cerevisiae. J Cell Biol. 2000;149:397-410 pubmed..cerevisiae and that a major fraction of internalized FM4-64 is secreted back into the medium within a few minutes. The rcy1Delta mutant is strongly defective in recycling. ..
- Radojevic V, Lin S, Burgunder J. Differential expression of dystrophin, utrophin, and dystrophin-associated proteins in human muscle culture. Cell Tissue Res. 2000;300:447-57 pubmed..In this study we demonstrated the establishment of a culture technique that should allow the close study of DAP expression in diseased muscle, including its use after gene modulatory strategies. ..
- Dessimoz J, Opoka R, Kordich J, Grapin Botton A, Wells J. FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo. Mech Dev. 2006;123:42-55 pubmed..These data show that FGF signaling is critical for patterning the gut tube by promoting posterior and inhibiting anterior endoderm cell fate. ..
- Brawand P, Lemonnier F, MacDonald H, Cerottini J, Held W. Transgenic expression of Ly49A on T cells impairs a specific antitumor response. J Immunol. 2000;165:1871-6 pubmed
- Schulz H, Hennecke H, Thony Meyer L. Prototype of a heme chaperone essential for cytochrome c maturation. Science. 1998;281:1197-200 pubmed..The heme was then released and delivered to apocytochrome c. Thus, CcmE can be viewed as a heme chaperone guiding heme to its appropriate biological partner and preventing illegitimate complex formation. ..
- Cartoni R, Leger B, Hock M, Praz M, Crettenand A, Pich S, et al. Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J Physiol. 2005;567:349-58 pubmed..Our results provide evidence that PGC-1alpha not only mediates the increased expression of oxidative phosphorylation genes but also mediates alterations in mitochondrial architecture in response to aerobic exercise in humans. ..
- Keller F, Levitt P. Developmental and regeneration-associated regulation of the limbic system associated membrane protein in explant cultures of the rat brain. Neuroscience. 1989;28:455-74 pubmed..Furthermore, we suggest that the reinnervation processes taking place after central nervous system injury may exhibit a similar molecular basis to the development of neural pathways. ..
- van den Broek M, Muller U, Huang S, Aguet M, Zinkernagel R. Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors. J Virol. 1995;69:4792-6 pubmed..Even though global antiviral immunoglobulin G (IgG) titers were within normal ranges, the IgG subclass distribution was heavily biased toward IgG1. ..
- Orci L, Stamnes M, Ravazzola M, Amherdt M, Perrelet A, Sollner T, et al. Bidirectional transport by distinct populations of COPI-coated vesicles. Cell. 1997;90:335-49 pubmed
- Rolink A, Melchers F. BAFFled B cells survive and thrive: roles of BAFF in B-cell development. Curr Opin Immunol. 2002;14:266-75 pubmed..Upon BAFF-influenced differentiation, immature B cells change their surface-IgM signal transduction machinery and proliferate rather than undergoing apoptosis. ..
- Marone R, Hess D, Dankort D, Muller W, Hynes N, Badache A. Memo mediates ErbB2-driven cell motility. Nat Cell Biol. 2004;6:515-22 pubmed..Our data suggest that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. ..
- Paoloni Giacobino A, Chen H, Peitsch M, Rossier C, Antonarakis S. Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. Genomics. 1997;44:309-20 pubmed..The gene was mapped to 21q22.3 between markers ERG and D21S56 in the same P1 as MX1. The physiological role of TMPRSS2 and its involvement in trisomy 21 phenotypes or monogenic disorders that map to HC21 are unknown. ..
- Crambert G, Fuzesi M, Garty H, Karlish S, Geering K. Phospholemman (FXYD1) associates with Na,K-ATPase and regulates its transport properties. Proc Natl Acad Sci U S A. 2002;99:11476-81 pubmed..In conclusion, this study demonstrates that PLM is a tissue-specific regulator of NKA that may play an essential role in muscle contractility. ..
- Mancini S, Mantei N, Dumortier A, Suter U, MacDonald H, Radtke F. Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood. 2005;105:2340-2 pubmed..In contrast to earlier reports, these data exclude an essential role for Jagged1-mediated Notch signaling during hematopoiesis. ..
- Xue G, von Schubert C, Hermann P, Peyer M, Maushagen R, Schmuckli Maurer J, et al. Characterisation of gp34, a GPI-anchored protein expressed by schizonts of Theileria parva and T. annulata. Mol Biochem Parasitol. 2010;172:113-20 pubmed publisher..Overexpression of Tp-gp34 and Ta-gp34 induced cytokinetic defects and resulted in accumulation of binucleated cells. These findings suggest that gp34 could contribute to important parasite-host interactions during host cell division...
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