Genomes and Genes
Experts and Doctors on membrane proteins in Japan
Topic: membrane proteins
Publications251 found, 100 shown here
- Ueda Y, Willmore L. Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis. Exp Brain Res. 2000;133:334-9 pubmed
- Takahashi Y, Kako K, Arai H, Ohishi T, Inada Y, Takehara A, et al. Characterization and identification of promoter elements in the mouse COX17 gene. Biochim Biophys Acta. 2002;1574:359-64 pubmed..These results indicated that Sp1, NRF-1 and NRF-2 are involved in basal transcription of the COX17 gene, similar to the transcription mechanism of other CCO-related genes. ..
- Horie M, Kajikawa H, Toba T. Identification of Lactobacillus crispatus by polymerase chain reaction targeting S-layer protein gene. Lett Appl Microbiol. 2002;35:57-61 pubmed..crispatus accurately and rapidly. To the authors' knowledge, this is the first paper to provide a PCR method for the specific identification of Lact. crispatus. ..
- Higashio H, Kohno K. A genetic link between the unfolded protein response and vesicle formation from the endoplasmic reticulum. Biochem Biophys Res Commun. 2002;296:568-74 pubmed..These findings suggest that the activation of the UPR affects ER-to-Golgi transport via stimulation of COPII vesicle formation from the ER. ..
- Nakada Y, Nishijyo T, Itoh Y. Divergent structure and regulatory mechanism of proline catabolic systems: characterization of the putAP proline catabolic operon of Pseudomonas aeruginosa PAO1 and its regulation by PruR, an AraC/XylS family protein. J Bacteriol. 2002;184:5633-40 pubmed..Thus, the proline utilization system of P. aeruginosa differs from that of P. putida with respect to putA structure, the organization of the putAP genes, and the regulatory mechanism of putA expression. ..
- Nagano O, Murakami D, Hartmann D, De Strooper B, Saftig P, Iwatsubo T, et al. Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation. J Cell Biol. 2004;165:893-902 pubmed..The spatio-temporal regulation of two independent signaling pathways for CD44 cleavage plays a crucial role in cell-matrix interaction and cell migration...
- Tahara Hanaoka S, Miyamoto A, Hara A, Honda S, Shibuya K, Shibuya A. Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands. Biochem Biophys Res Commun. 2005;329:996-1000 pubmed..We demonstrated that ligand binding of murine DNAM-1 induced a costimulatory signal in antigen-specific CD8+ T cells. These results should provide a useful animal model to explore a role of DNAM-1 in immune responses in vivo. ..
- Yoshida T, Hanawa H, Toba K, Watanabe H, Watanabe R, Yoshida K, et al. Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis. Cardiovasc Res. 2005;68:278-88 pubmed..It is further suggested that fractalkine, IL-10, and MCP-1 expressed in NCNI cells or cardiomyocytes regulate inflammatory cells. ..
- Zhang J, Migita O, Koga M, Shibasaki M, Arinami T, Noguchi E. Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. Pediatr Allergy Immunol. 2006;17:242-9 pubmed..Our findings indicate that CYSLTR1 polymorphisms are not likely to be involved in the development of asthma/rhinitis, but it is possible that these polymorphisms could influence drug responses in individuals with atopic diseases. ..
- Takada A, Umitsuki G, Nagai K, Wachi M. RNase E is required for induction of the glutamate-dependent acid resistance system in Escherichia coli. Biosci Biotechnol Biochem. 2007;71:158-64 pubmed..These results indicate that RNase E is required for induction of the glutamate-dependent acid resistance system in a RpoS-independent manner. ..
- Sakaushi S, Inoue K, Zushi H, Senda Murata K, Fukada T, Oka S, et al. Dynamic behavior of FCHO1 revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation. Biosci Biotechnol Biochem. 2007;71:1764-8 pubmed..The periodicity of FCHO1 was temporally correlated with that of clathrin, suggesting that FCHO1 is involved in clathrin-coated vesicle formation. ..
- Hanagata N, Li X. Osteoblast-enriched membrane protein IFITM5 regulates the association of CD9 with an FKBP11-CD81-FPRP complex and stimulates expression of interferon-induced genes. Biochem Biophys Res Commun. 2011;409:378-84 pubmed publisher..Induction of these genes likely resulted from dissociation of CD9 from the FKBP11-CD81-[FPRP/CD9] complex. Cumulatively, these results suggest that IFITM5 is involved not only in bone formation, but also in immune system activity. ..
- Matsumoto M, Iwamasa K, Rennert P, Yamada T, Suzuki R, Matsushima A, et al. Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis. J Immunol. 1999;163:1584-91 pubmed
- Murdiastuti K, Miki O, Yao C, Parvin M, Kosugi Tanaka C, Akamatsu T, et al. Divergent expression and localization of aquaporin 5, an exocrine-type water channel, in the submandibular gland of Sprague-Dawley rats. Pflugers Arch. 2002;445:405-12 pubmed..Our present study suggests the existence of genetic variation in the expression of a water channel protein, AQP5, in rats. ..
- Katoh M, Katoh M. Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico. Int J Mol Med. 2004;14:327-31 pubmed..elegans 2B609 were found consisting of N-terminal FCH domain and C-terminal FOH domain. This is the first report on identification and characterization of evolutionarily conserved FCHO homologs as well as the novel FOH domain. ..
- Ozaki C, Yoshioka M, Tominaga S, Osaka Y, Obata S, Suzuki S. p120-Catenin is essential for N-cadherin-mediated formation of proper junctional structure, thereby establishing cell polarity in epithelial cells. Cell Struct Funct. 2010;35:81-94 pubmed..Similar results were obtained when E-cadherin mutants comparable to those of N-cadherin were used, suggesting that p120-catenin plays the same role in the function of other classical cadherins. ..
- Kajiho Y, Harita Y, Kurihara H, Horita S, Matsunaga A, Tsurumi H, et al. SIRP? interacts with nephrin at the podocyte slit diaphragm. FEBS J. 2012;279:3010-21 pubmed publisher..Thus, SIRP? interacts with nephrin at the SD, and its phosphorylation is dynamically regulated in proteinuric states. Our data provide new molecular insights into the phosphorylation events triggered by podocyte injury. ..
- Shimizu T, Hiyama T, Ikeuchi M, Koike H, Inoue Y. Nucleotide sequence of the psaC gene of the cyanobacterium Synechococcus vulcanus. Nucleic Acids Res. 1990;18:3644 pubmed
- Matsuyama S, Akimaru J, Mizushima S. SecE-dependent overproduction of SecY in Escherichia coli. Evidence for interaction between two components of the secretory machinery. FEBS Lett. 1990;269:96-100 pubmed..It is suggested that SecY and SecE interact with each other in the cytoplasmic membrane. The numbers of the SecY and SecE molecules per cell were estimated. ..
- Akiyama Y, Yoshihisa T, Ito K. FtsH, a membrane-bound ATPase, forms a complex in the cytoplasmic membrane of Escherichia coli. J Biol Chem. 1995;270:23485-90 pubmed..We suggest that the N-terminal transmembrane region of FtsH mediates directly the interaction between the FtsH subunits. ..
- Watabe S, Kohno H, Kouyama H, Hiroi T, Yago N, Nakazawa T. Purification and characterization of a substrate protein for mitochondrial ATP-dependent protease in bovine adrenal cortex. J Biochem. 1994;115:648-54 pubmed..Since a segment around AA47 was highly conserved, this residue may be important for the biochemical functions of SP-22. ..
- Pan J, Nakanishi K, Yutsudo M, Inoue H, Li Q, Oka K, et al. Isolation of a novel gene down-regulated by v-src. FEBS Lett. 1996;383:21-5 pubmed..We named the gene drs for a gene down-regulated by v-src. ..
- Saito T, Endo T, Kawaguchi A, Ikeda M, Nakazato M, Kogai T, et al. Increased expression of the Na+/I- symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue. J Clin Endocrinol Metab. 1997;82:3331-6 pubmed..The amount of NIS protein was also increased 3.1-fold in Graves' thyroid tissue compared with that in normal thyroid tissue. The increased expression of NIS may thus contribute to the development of Graves' disease. ..
- Odani T, Shimma Y, Wang X, Jigami Y. Mannosylphosphate transfer to cell wall mannan is regulated by the transcriptional level of the MNN4 gene in Saccharomyces cerevisiae. FEBS Lett. 1997;420:186-90 pubmed..This type of transcriptional regulation is observed in many stress response genes, implying that mannosylphosphate transfer is involved in the cellular response to a variety of stresses. ..
- Kato J, Nakamura T, Kuroda A, Ohtake H. Cloning and characterization of chemotaxis genes in Pseudomonas aeruginosa. Biosci Biotechnol Biochem. 1999;63:155-61 pubmed..This gene was located at least 1,800 kb away from the chemotaxis gene cluster and encoded a putative polypeptide that had 32% amino acid identity with E. coli CheR. ..
- Kawabe Y, Enomoto T, Morio T, Urushihara H, Tanaka Y. LbrA, a protein predicted to have a role in vesicle trafficking, is necessary for normal morphogenesis in Polysphondylium pallidum. Gene. 1999;239:75-9 pubmed..As far as we know, this is the first paper to show that a p24 family member is implicated in morphogenesis...
- Hosoya M, Moriya T, Kawamata Y, Ohkubo S, Fujii R, Matsui H, et al. Identification and functional characterization of a novel subtype of neuromedin U receptor. J Biol Chem. 2000;275:29528-32 pubmed..The identification of specific and functional receptor subtypes for neuromedin U will facilitate the study of their physiological roles and the search for their specific agonists and antagonists. ..
- Fukumoto T, Watanabe Fukunaga R, Fujisawa K, Nagata S, Fukunaga R. The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells. J Biol Chem. 2001;276:38441-8 pubmed
- Araki K, Nozaki K, Ueba T, Tatsuka M, Hashimoto N. High expression of Aurora-B/Aurora and Ipll-like midbody-associated protein (AIM-1) in astrocytomas. J Neurooncol. 2004;67:53-64 pubmed..The modification of the level of Aurora-B/AIM-1 expression might be a new target for glioma therapy. ..
- Ichinoe M, Mikami T, Shiraishi H, Okayasu I. High microvascular density is correlated with high VEGF, iNOS and COX-2 expression in penetrating growth-type early gastric carcinomas. Histopathology. 2004;45:612-8 pubmed..Increased MVD in PEN type has an intimate causal relationship to angiogenic factors, high VEGF and iNOS expression. The SUP type, in contrast, has characteristics of low angiogenesis. ..
- Ando A, Suzuki C. Cooperative function of the CHD5-like protein Mdm39p with a P-type ATPase Spf1p in the maintenance of ER homeostasis in Saccharomyces cerevisiae. Mol Genet Genomics. 2005;273:497-506 pubmed..Our findings imply a homeostatic role for Mdm39p, which may be related to the regulation of calcium ion fluxes in the ER, and is indispensable for mutants that lack Spf1p...
- Koike S, Keino Masu K, Ohto T, Masu M. The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions as a signal peptide. Genes Cells. 2006;11:133-42 pubmed..These data demonstrate that the N-terminal hydrophobic sequence of autotaxin functions as a signal peptide, not as a transmembrane segment, and thus autotaxin is synthesized as a secreted protein. ..
- Shimomura S. Identification of a glycosylphosphatidylinositol-anchored plasma membrane protein interacting with the C-terminus of auxin-binding protein 1: a photoaffinity crosslinking study. Plant Mol Biol. 2006;60:663-77 pubmed publisher..The present results indicate that ABP1 may contribute to directional cell growth processes via the GPI-anchored plasma membrane protein SKU5 and its family members...
- Shi J, Yoshino O, Osuga Y, Koga K, Hirota Y, Nose E, et al. Bone morphogenetic protein-2 (BMP-2) increases gene expression of FSH receptor and aromatase and decreases gene expression of LH receptor and StAR in human granulosa cells. Am J Reprod Immunol. 2011;65:421-7 pubmed publisher..HCG can modulate BMP-2 function by controlling BMP-2 and BAMBI expression. ..
- Yoshida J, Iwabuchi K, Matsui T, Ishibashi T, Masuoka T, Nishio M. Knockdown of stromal interaction molecule 1 (STIM1) suppresses store-operated calcium entry, cell proliferation and tumorigenicity in human epidermoid carcinoma A431 cells. Biochem Pharmacol. 2012;84:1592-603 pubmed publisher..These results indicate that STIM1 plays an important role in SOCE, cell-growth and tumorigenicity in human epidermoid carcinoma A431cells, suggesting the potential use of STIM1-targeting agents for treating epidermoid carcinoma. ..
- Moriyama M, Moriyama H, Uda J, Matsuyama A, Osawa M, Hayakawa T. BNIP3 plays crucial roles in the differentiation and maintenance of epidermal keratinocytes. J Invest Dermatol. 2014;134:1627-1635 pubmed publisher..This suggests that BNIP3 has a protective effect against UVB-induced apoptosis in keratinocytes. Overall, our data provide valuable insights into the role of BNIP3 in the differentiation and maintenance of epidermal keratinocytes. ..
- Lam A, Bert N, Ho S, Shen Y, Tang L, Xiong G, et al. RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma. Cancer Res. 2014;74:2193-2203 pubmed publisher..Taken together, our results suggest that genomic damage in tumor cells leads to activation of STING-dependent DNA sensor pathways, thereby activating RAE1 and enabling tumor immunosurveillance...
- Hisabe T, Yao K, Imamura K, Ishihara H, Yamasaki K, Yasaka T, et al. Novel Endoscopic Findings as Visualized by Magnifying Endoscopy with Narrow-Band Imaging: White Opaque Substance Is Present in Colorectal Hyperplastic Polyps. Digestion. 2016;93:127-31 pubmed publisher..Adipophilin was present in 24 of the 26 colorectal hyperplastic polyps (92.3%). This study is the first to demonstrate that WOS (i.e. lipid droplets) accumulates in the epithelium of colorectal hyperplastic polyps. ..
- Tanimoto T, Hoshijima M, Kawata M, Yamamoto K, Ohmori T, Shiku H, et al. Binding of ras p21 to bands 4.2 and 6 of human erythrocyte membranes. FEBS Lett. 1988;226:291-6 pubmed..2 or 6 protein. These results indicate that v-Ki-ras p21 can bind directly to bands 4.2 and 6 of human erythrocyte membranes as far as tested in an in vitro cell-free system. ..
- Fukuta M, Uchimura K, Nakashima K, Kato M, Kimata K, Shinomura T, et al. Molecular cloning and expression of chick chondrocyte chondroitin 6-sulfotransferase. J Biol Chem. 1995;270:18575-80 pubmed..The amino-terminal amino acid sequence of the purified protein was found in the transmembrane domain, suggesting that the purified protein might be released from the chondrocytes after proteolytic cleavage in the transmembrane domain. ..
- Kutsukake K, Minamino T, Yokoseki T. Isolation and characterization of FliK-independent flagellation mutants from Salmonella typhimurium. J Bacteriol. 1994;176:7625-9 pubmed..On the basis of these results, we discuss the mechanism of suppression of the fliK defects by the flhB mutations and propose a hypothesis on the export switching machinery of the flagellar proteins. ..
- Akagawa E, Kurita K, Sugawara T, Nakamura K, Kasahara Y, Ogasawara N, et al. Determination of a 17,484 bp nucleotide sequence around the 39 degrees region of the Bacillus subtilis chromosome and similarity analysis of the products of putative ORFs. Microbiology. 1995;141 ( Pt 12):3241-5 pubmed..The amino acid sequence of Orf3 showed 34% identity with that of LeuC of B. subtilis, though they seem to be functionally different. The remaining seven ORFs did not show similarity to any known proteins. ..
- Shirai Y, Akiyama Y, Ito K. Suppression of ftsH mutant phenotypes by overproduction of molecular chaperones. J Bacteriol. 1996;178:1141-5 pubmed..These results suggest that FtsH functions can be somehow compensated for when the cellular concentrations of some molecular chaperones increase. ..
- Akiyama H, Shigeno C, Hiraki Y, Shukunami C, Kohno H, Akagi M, et al. Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5. Biochem Biophys Res Commun. 1997;235:142-7 pubmed..Our data suggest that hh signalling molecules may be involved in chondrogenesis and cartilage differentiation in ATDC5 cells. ..
- Kobayashi H, Yamamoto M, Aono R. Appearance of a stress-response protein, phage-shock protein A, in Escherichia coli exposed to hydrophobic organic solvents. Microbiology. 1998;144 ( Pt 2):353-9 pubmed publisher..Introduction of a multi-copy plasmid vector carrying the psp operon into E. coli improved the survival frequency of cells exposed suddenly to n-hexane but not the growth rate of cells growing in the presence of n-hexane...
- Matsushima M, Fujiwara T, Takahashi E, Minaguchi T, Eguchi Y, Tsujimoto Y, et al. Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3. Genes Chromosomes Cancer. 1998;21:230-5 pubmed
- Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). Cytogenet Cell Genet. 1997;79:103-8 pubmed..These data suggest that members of this novel gene family may play important roles in suppression of glioblastoma. BAI1, BAI2 and BAI3 were mapped to 8q24, 1p35 and 6q12, respectively. ..
- Koarada S, Tada Y, Ushiyama O, Morito F, Suzuki N, Ohta A, et al. B cells lacking RP105, a novel B cell antigen, in systemic lupus erythematosus. Arthritis Rheum. 1999;42:2593-600 pubmed..These findings suggest that loss of RP105 is associated with B cell activation and increased disease activity in SLE patients. ..
- Ikegami T, Okada T, Ohki I, Hirayama J, Mizuno T, Shirakawa M. Solution structure and dynamic character of the histidine-containing phosphotransfer domain of anaerobic sensor kinase ArcB from Escherichia coli. Biochemistry. 2001;40:375-86 pubmed..This is consistent with the solution structure of HPt(ArcB), in which the imidazole ring of His717 is exposed to the solvent. ..
- Katoh M, Katoh M. FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26. Int J Oncol. 2003;22:1155-9 pubmed..Tumor suppressor genes closely linked to oncogenes might be excluded from amplicon through a breakage-fusion-bridge process during oncogene amplification. ..
- Katoh M, Katoh M. Identification and characterization of human ZPBP-like gene in silico. Int J Mol Med. 2003;12:399-404 pubmed..Comparative genomics revealed that ZPBPL-ZNFN1A3-GRB7-ERBB2 and ZPBP-ZNFN1A1-GRB10-EGFR loci were paralogous regions within the human genome. This is the first report on identification and characterization of the ZPBPL gene. ..
- Takano Y, Ohguro H, Dezawa M, Ishikawa H, Yamazaki H, Ohguro I, et al. Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse. Biochem Biophys Res Commun. 2004;313:1015-22 pubmed..It is suggested that some types of Ca(2+) channel blockers, such as nilvadipine and nicardipine, are able to preserve photoreceptor cells in rd mouse and can potentially be used to treat some RP patients. ..
- Suzuki K, Watanabe K, Masumura T, Kitamura S. Characterization of soluble and putative membrane-bound UDP-glucuronic acid decarboxylase (OsUXS) isoforms in rice. Arch Biochem Biophys. 2004;431:169-77 pubmed publisher..In the present study, we report that the UXS2-type enzyme of rice is not only characterized for the first time but also show significant findings involved in the gene expression of OsUXSs...
- Chinami M, Yano Y, Yang X, Salahuddin S, Moriyama K, Shiroishi M, et al. Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. J Biol Chem. 2005;280:17235-42 pubmed..We show that this interaction not only facilitates access of KAP to Thr160 and accelerates KAP kinetics, but also forces exclusion of cyclin A from the KAP.cdk2 complex. ..
- Hanagata N, Li X, Morita H, Takemura T, Li J, Minowa T. Characterization of the osteoblast-specific transmembrane protein IFITM5 and analysis of IFITM5-deficient mice. J Bone Miner Metab. 2011;29:279-90 pubmed publisher..Overall, the effect of Ifitm5 deficiency on bone formation was less than we expected. We hypothesize that this may have resulted from a compensatory mechanism in Ifitm5-deficient mice. ..
- Takeuchi F, Yamamoto K, Katsuya T, Nabika T, Sugiyama T, Fujioka A, et al. Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals. Diabetologia. 2011;54:1350-9 pubmed publisher..Six (of ten) loci exert diabetogenic effects in the Japanese, although relatively modest in size, and independently of increased adiposity. ..
- Takeda M, Nagasaka T, Dong Sheng S, Nishie H, Oka T, Yamada E, et al. Expansion of CpG methylation in the SFRP2 promoter region during colorectal tumorigenesis. Acta Med Okayama. 2011;65:169-77 pubmed..0001), suggesting that genetic alteration in the RAS-RAF pathway might precede the spread of CpG methylation through the SFRP2 promoter, which is observed in over 60% of advanced colorectal tumors. ..
- Katayama K, Sasaki T, Goto S, Ogasawara K, Maru H, Suzuki K, et al. Insertional mutation in the Golgb1 gene is associated with osteochondrodysplasia and systemic edema in the OCD rat. Bone. 2011;49:1027-36 pubmed publisher..Therefore, we concluded that mutation of the Golgb1 gene is responsible for the phenotypic characteristics including osteochondrodysplasia of ocd/ocd, and that giantin plays a pivotal role in multiple aspects of chondrogenesis...
- Fujita Y, Nagaosa K, Shiratsuchi A, Nakanishi Y. Role of NPxY motif in Draper-mediated apoptotic cell clearance in Drosophila. Drug Discov Ther. 2012;6:291-7 pubmed..In summary, we demonstrated that Draper binds to its ligand Pretaporter using EGF-like sequences, and that the NPxY motif in the intracellular region of Draper plays an essential role in its actions as an engulfment receptor. ..
- Ikeda A, Kajiwara K, Iwamoto K, Makino A, Kobayashi T, Mizuta K, et al. Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis. Yeast. 2016;33:37-42 pubmed publisher..The results suggest that Arv1 function in GPI biosynthesis may be conserved in all eukaryotes, from yeast to humans. ..
- Suzuki E, Kamiya H. PSD-95 regulates synaptic kainate receptors at mouse hippocampal mossy fiber-CA3 synapses. Neurosci Res. 2016;107:14-9 pubmed publisher..Analysis of KARs-mediated miniature EPSCs also suggested reduced synaptic KARs. All the evidence supports critical roles of PSD-95 in regulating synaptic KARs. ..
- Nagasawa S, Tokishita S, Aiba H, Mizuno T. A novel sensor-regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive responses in Escherichia coli. Mol Microbiol. 1992;6:799-807 pubmed..coli genetic map. The BarA protein in isolated membranes was demonstrated in vitro to undergo phosphorylation in the presence of ATP. ..
- Ohsumi T, Ichimura T, Sugano H, Omata S, Isobe T, Kuwano R. Ribosome-binding protein p34 is a member of the leucine-rich-repeat-protein superfamily. Biochem J. 1993;294 ( Pt 2):465-72 pubmed..The cytoplasmic domain also contains a characteristic hydrophilic region with abundant charged amino acids. These structural regions may be important for the observed ribosome-binding activity of the p34 protein. ..
- Kontinen V, Tokuda H. Overexpression of phosphatidylglycerophosphate synthase restores protein translocation in a secG deletion mutant of Escherichia coli at low temperature. FEBS Lett. 1995;364:157-60 pubmed..Furthermore, protein translocation in the deletion mutant was stimulated when it harbored a plasmid carrying pgsA. A possible mechanism underlying the pgsA-dependent suppression of the secG deletion mutation is discussed. ..
- Iida Y, Takeda J, Miyata T, Inoue N, Nishimura J, Kitani T, et al. Characterization of genomic PIG-A gene: a gene for glycosylphosphatidylinositol-anchor biosynthesis and paroxysmal nocturnal hemoglobinuria. Blood. 1994;83:3126-31 pubmed..We report pairs of oligonucleotide primers for polymerase chain reaction that should be useful to amplify and analyze various regions of the PIG-A gene in patients with PNH. ..
- Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, et al. A novel partner for the GTP-bound forms of rho and rac. FEBS Lett. 1995;377:243-8 pubmed..We recently identified three others putative rho effectors characterized by a common rho binding motif. Citron does not share this motif and displays a distinctive protein organization, thus defining a separate class of rho partners. ..
- Okuda M, Saito H, Urakami Y, Takano M, Inui K. cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun. 1996;224:500-7 pubmed..These findings suggest that OCT2 is responsible for the transport of cationic drugs in the kidney...
- Furuhata T, Tokino T, Urano T, Nakamura Y. Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity. Oncogene. 1996;13:1965-70 pubmed
- Tsujimura A, Yasojima K, Hashimoto Gotoh T. Cloning of Xenopus presenilin-alpha and -beta cDNAs and their differential expression in oogenesis and embryogenesis. Biochem Biophys Res Commun. 1997;231:392-6 pubmed..We propose that presenilins may function in preventing cells from undergoing apoptotic degeneration particularly prior to embryonic development and in developmentally matured tissues. ..
- Takeuchi T, Miyahara K, Hirata D, Miyakawa T. Mutational analysis of Yap1 protein, an AP-1-like transcriptional activator of Saccharomyces cerevisiae. FEBS Lett. 1997;416:339-43 pubmed..The carboxy-terminal domain of Yap1 appears to act negatively in cadmium resistance. ..
- Ishibashi K, Marumo F. Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis. Biochem Biophys Res Commun. 1998;245:589-93 pubmed..The identification of a new member of Na channel specifically expressed in testis will expand the role of this channel family to the reproduction physiology. ..
- Nishi M, Komazaki S, Iino M, Kangawa K, Takeshima H. Mitsugumin23, a novel transmembrane protein on endoplasmic reticulum and nuclear membranes. FEBS Lett. 1998;432:191-6 pubmed..The distribution and primary structure indicate the possibility that mitsugumin23 interacts with cytoplasmic protein(s) and participates in a housekeeping function on the intracellular organelle membranes. ..
- Taketo M. COX-2 and colon cancer. Inflamm Res. 1998;47 Suppl 2:S112-6 pubmed..The results provide direct genetic evidence that COX-2 plays a key role in tumorigenesis, and indicate that COX-2-selective inhibitors can be a new class of therapeutic agents for colorectal polyposis and cancer. ..
- Ikebe T, Iyoda S, Kutsukake K. Promoter analysis of the class 2 flagellar operons of Salmonella. Genes Genet Syst. 1999;74:179-83 pubmed..Truncation of this sequence from the flgB promoter reduced its transcriptional activity to the background level, indicating that this is an essential cis-acting element for transcription of the class 2 operons. ..
- Suzuki K, Yamanishi K, Mori O, Kamikawa M, Andersen B, Kato S, et al. Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene. FEBS Lett. 2000;481:53-6 pubmed..These data suggest that Fgf10 is required for embryonic epidermal morphogenesis but is not essential for hair follicle development. ..
- Motohashi T, Miyoshi S, Osawa M, Eyre H, Sutherland G, Matsuda Y, et al. Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83. Biochem Biophys Res Commun. 2000;276:244-50 pubmed..Among hematopoietic cells, it was highly expressed in resting T lymphocytes and was downregulated by cell activation, suggestive of its biological role related to the T cell resting status. ..
- Suzuki A, Kadota N, Hara T, Nakagami Y, Izumi T, Takenawa T, et al. Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src. Oncogene. 2000;19:5842-50 pubmed..These results may imply that meltrin alpha cytoplasmic domain is involved in a signal transduction for some biological function through the interaction with SH3-containing proteins. ..
- Fujihira E, Tamura N, Yamaguchi A. Membrane topology of a multidrug efflux transporter, AcrB, in Escherichia coli. J Biochem. 2002;131:145-51 pubmed..Three of the four short periplasmic loop regions were covered by the two large periplasmic loop domains and were not exposed to the water phase until one of the two large periplasmic loops was removed. ..
- Gotoh M, Yada T, Sato T, Akashima T, Iwasaki H, Mochizuki H, et al. Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine. J Biol Chem. 2002;277:38179-88 pubmed..This enzyme could play a role in the synthesis of chondroitin sulfate as a glucuronyltransferase. ..
- Mori H, Ito K. Biochemical characterization of a mutationally altered protein translocase: proton motive force stimulation of the initiation phase of translocation. J Bacteriol. 2003;185:405-12 pubmed..The proton motive force-dependent step proved to lie before signal peptide cleavage. We suggest that the proton motive force assists in the initiation phase of protein translocation. ..
- Ito Y, Katagiri H, Ishii K, Kakita A, Hayashi I, Majima M. Effects of selective cyclooxygenase inhibitors on ischemia/reperfusion-induced hepatic microcirculatory dysfunction in mice. Eur Surg Res. 2003;35:408-16 pubmed..These results suggest that COX-1 and COX-2 contribute to I/R-induced hepatic microvascular and hepatocellular injury partly through TNF-alpha production, and that TXs derived from COX are partly responsible for I/R-induced liver injury. ..
- Katoh M, Katoh M. Identification and characterization of human TMEM25 and mouse Tmem25 genes in silico. Oncol Rep. 2004;12:429-33 pubmed..Human TMEM25 gene was located at the 11q23.3 oncogenomic recombination hotspot around the MLL amplicon and the neuroblastoma deleted region. TMEM25 is a target of pharmacogenomics in the field of oncology and regenerative medicine. ..
- Toda T, Chiyonobu T, Xiong H, Tachikawa M, Kobayashi K, Manya H, et al. Fukutin and alpha-dystroglycanopathies. Acta Myol. 2005;24:60-3 pubmed..All are characterized by hypoglycosylated alpha-dystroglycan. Fukutin's function and the relation with other alpha-dystroglycanopathies are discussed. ..
- Sugihara S, Katsutani S, Deckmyn H, Fujimura K, Kimura A. Roles of Src-like adaptor protein 2 (SLAP-2) in GPVI-mediated platelet activation SLAP-2 and GPVI signaling. Thromb Res. 2010;126:e276-85 pubmed publisher..In platelets, SLAP-2 may have function as a negative regulator of GPVI-mediated signaling by interacting with c-Cbl, being similar to that reported in T cells. ..
- Nishino K, Yamasaki S, Hayashi Nishino M, Yamaguchi A. Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli. J Antimicrob Chemother. 2011;66:291-6 pubmed publisher..These results indicate that DsrA modulates multidrug efflux through activation of genes encoding the MdtEF pump in E. coli. ..
- Sanda S, Yoshida K, Kuwano M, Kawamura T, Munekage Y, Akashi K, et al. Responses of the photosynthetic electron transport system to excess light energy caused by water deficit in wild watermelon. Physiol Plant. 2011;142:247-64 pubmed publisher..The qualitative changes in photosynthetic proteins may switch the photosynthetic electron transport from normal photosynthesis mode to stress-tolerance mode. ..
- Ito K, Kuno A, Ikehara Y, Sugiyama M, Saito H, Aoki Y, et al. LecT-Hepa, a glyco-marker derived from multiple lectins, as a predictor of liver fibrosis in chronic hepatitis C patients. Hepatology. 2012;56:1448-56 pubmed publisher..LecT-Hepa given by a combination of the two glyco-parameters is a reliable method for determining the fibrosis stage and is a potential substitute for liver biopsy. ..
- Chutiwitoonchai N, Hiyoshi M, Hiyoshi Yoshidomi Y, Hashimoto M, Tokunaga K, Suzu S. Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins. Microbes Infect. 2013;15:280-90 pubmed publisher..These characteristics lead to a better understanding of the mechanism by which IFITMs restrict HIV-1 and other viruses...