Experts and Doctors on membrane proteins in Germany

Summary

Locale: Germany
Topic: membrane proteins

Top Publications

  1. Steinmeyer K, Ortland C, Jentsch T. Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel. Nature. 1991;354:301-4 pubmed
    ..This and the functional destruction of this channel in mouse myotonia suggests that we have cloned the major skeletal muscle chloride channel. ..
  2. Simos G, Segref A, Fasiolo F, Hellmuth K, Shevchenko A, Mann M, et al. The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases. EMBO J. 1996;15:5437-48 pubmed
    ..Arc1p is, therefore, a yeast protein with dual specificity: it associates with tRNA and aminoacyl-tRNA synthetases. This functional interaction may be required for efficient aminoacylation in vivo. ..
  3. Schwab J, Nguyen T, Postler E, Meyermann R, Schluesener H. Selective accumulation of cyclooxygenase-1-expressing microglial cells/macrophages in lesions of human focal cerebral ischemia. Acta Neuropathol. 2000;99:609-14 pubmed
    ..Therefore we suggest that therapeutic approaches based on selective COX-2 blocking might not be sufficient for suppressing the local synthesis of prostanoids. ..
  4. Arnhold S, Heiduschka P, Klein H, Absenger Y, Basnaoglu S, Kreppel F, et al. Adenovirally transduced bone marrow stromal cells differentiate into pigment epithelial cells and induce rescue effects in RCS rats. Invest Ophthalmol Vis Sci. 2006;47:4121-9 pubmed
    ..Taken together, these results raise the possibility that MSCs have the potency to replace diseased RPE cells and deliver therapeutic proteins into the subretinal space to protect photoreceptor cells from degeneration. ..
  5. Mees S, Mennigen R, Spieker T, Rijcken E, Senninger N, Haier J, et al. Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and beta-catenin. Int J Colorectal Dis. 2009;24:361-8 pubmed publisher
    ..TJ proteins claudin-1, claudin-3, claudin-4, and the AJ protein beta-catenin are overexpressed in CAC. This suggests that these proteins may become potential markers and targets in CAC. ..
  6. Bramkamp M. The putative Bacillus subtilis L,D-transpeptidase YciB is a lipoprotein that localizes to the cell poles in a divisome-dependent manner. Arch Microbiol. 2010;192:57-68 pubmed publisher
    ..Evidence is shown that YciB localizes to the cell poles. YciB localization depends on the existence of a mature divisome, suggesting that L,D-transpeptidases are, like penicillin-binding proteins, part of the divisome. ..
  7. Jose J, Maas R, Teese M. Autodisplay of enzymes--molecular basis and perspectives. J Biotechnol. 2012;161:92-103 pubmed publisher
    ..Applications that will provide sustainable solutions towards a bio-based industry are discussed. ..
  8. Kalin N, Dork T, Tummler B. A cystic fibrosis allele encoding missense mutations in both nucleotide binding folds of the cystic fibrosis transmembrane conductance regulator. Hum Mutat. 1992;1:204-10 pubmed
    ..Although F508C has been classified as a neutral sequence variation because of its discovery in healthy delta F508 gene carriers, it may nevertheless influence CFTR dysfunction caused by the S1251N mutation. ..
  9. Rohrback M, Paul S, Koster W. In vivo reconstitution of an active siderophore transport system by a binding protein derivative lacking a signal sequence. Mol Gen Genet. 1995;248:33-42 pubmed
    ..Moreover, purification of modified periplasmic proteins from the cytosol may be a useful approach for recovery of many polypeptides which are normally exported across the inner membrane and can cause toxicity problems when overproduced. ..

More Information

Publications612 found, 100 shown here

  1. Gournier H, Stenmark H, Rybin V, Lippe R, Zerial M. Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion. EMBO J. 1998;17:1930-40 pubmed
    ..Our results suggest that Rab5 binds to at least two distinct effectors which cooperate for optimal endocytic membrane docking and fusion. ..
  2. Teismann P, Ferger B. Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease. Synapse. 2001;39:167-74 pubmed
    ..5 and 50 mg/kg). In conclusion, the inhibition of either COX-1/COX-2 by acetylsalicylic acid or preferentially COX-2 by meloxicam provided a clear neuroprotection against MPTP-toxicity on the striatal and nigral levels. ..
  3. Mund T, Gewies A, Schoenfeld N, Bauer M, Grimm S. Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum. FASEB J. 2003;17:696-8 pubmed
    ..Its down-regulation in certain tumors suggests that Spike may also play a role in tumorigenesis. Our findings add new insight for how BH3-only and antiapoptotic Bcl-2 proteins regulate cell death. ..
  4. Schlickum S, Moghekar A, Simpson J, Steglich C, O Brien R, Winterpacht A, et al. LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein. Genomics. 2004;83:254-61 pubmed
    ..The present study presents information about a possible function for LETM1 and suggests that at least some (neuromuscular) features of WHS may be caused by mitochondrial dysfunction. ..
  5. Eitinger T, Suhr J, Moore L, Smith J. Secondary transporters for nickel and cobalt ions: theme and variations. Biometals. 2005;18:399-405 pubmed
  6. Varoqueaux F, Aramuni G, Rawson R, Mohrmann R, Missler M, Gottmann K, et al. Neuroligins determine synapse maturation and function. Neuron. 2006;51:741-54 pubmed
    ..Our data show that neuroligins are required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts. ..
  7. Atanackovic D, Arfsten J, Cao Y, Gnjatic S, Schnieders F, Bartels K, et al. Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation. Blood. 2007;109:1103-12 pubmed
    ..Immune responses induced by alloSCT could be boosted by active CT antigen-specific immunotherapy, which might help to achieve long-lasting remissions in patients with MM. ..
  8. Gergs U, Berndt T, Buskase J, Jones L, Kirchhefer U, Müller F, et al. On the role of junctin in cardiac Ca2+ handling, contractility, and heart failure. Am J Physiol Heart Circ Physiol. 2007;293:H728-34 pubmed
    ..Our results demonstrate that an increased expression of junctin is associated with an impaired Ca(2+) homeostasis. Downregulation of junctin in human heart failure may thus be a compensatory mechanism. ..
  9. Krappmann A, Taheri N, Heinrich M, Mösch H. Distinct domains of yeast cortical tag proteins Bud8p and Bud9p confer polar localization and functionality. Mol Biol Cell. 2007;18:3323-39 pubmed
    ..In summary, our study suggests that Bud8p and Bud9p carry distinct domains for delivery of the proteins to the cell poles, for interaction with the general budding machinery and for association with other cortical tag proteins. ..
  10. Tsarovina K, Schellenberger J, Schneider C, Rohrer H. Progenitor cell maintenance and neurogenesis in sympathetic ganglia involves Notch signaling. Mol Cell Neurosci. 2008;37:20-31 pubmed
  11. Groer G, Haslbeck M, Roessle M, Gessner A. Structural characterization of soluble E-Syt2. FEBS Lett. 2008;582:3941-7 pubmed publisher
    ..Quantitative analysis of the calcium binding revealed an apparent binding constant of 100muM. This is the first structural study of a multi-C2 protein, presumably involved in Ca-dependent signalling events. ..
  12. Dultz E, Ellenberg J. Live imaging of single nuclear pores reveals unique assembly kinetics and mechanism in interphase. J Cell Biol. 2010;191:15-22 pubmed publisher
    ..This inverse order of recruitment and the overall much slower kinetics compared with postmitotic NPC assembly support the conclusion that the two processes occur by distinct molecular mechanisms. ..
  13. Schumann W. FtsH--a single-chain charonin?. FEMS Microbiol Rev. 1999;23:1-11 pubmed
    ..Therefore, FtsH may serve to maintain quality control of some cytoplasmic and membrane proteins. Such ATP-dependent proteases with intrinsic chaperone activity have been designated charonins. ..
  14. Otto E, Kispert A, Schätzle -, Lescher B, Rensing C, Hildebrandt F. Nephrocystin: gene expression and sequence conservation between human, mouse, and Caenorhabditis elegans. J Am Soc Nephrol. 2000;11:270-82 pubmed
    ..The previously described discrepancy between widespread tissue expression and the restriction of symptoms to the kidney has now been confirmed by an in-depth expression study. ..
  15. Sohrt K, Soll J. Toc64, a new component of the protein translocon of chloroplasts. J Cell Biol. 2000;148:1213-21 pubmed
    ..We propose that Toc64 functions early in preprotein translocation, maybe as a docking protein for cytosolic cofactors of the protein import into chloroplasts. ..
  16. Kather B, Stingl K, van der Rest M, Altendorf K, Molenaar D. Another unusual type of citric acid cycle enzyme in Helicobacter pylori: the malate:quinone oxidoreductase. J Bacteriol. 2000;182:3204-9 pubmed
    ..pylori possesses a complete citric acid cycle, but one which deviates from the standard textbook example in three steps...
  17. Walther K, Krauss M, Diril M, Lemke S, Ricotta D, Honing S, et al. Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating. EMBO Rep. 2001;2:634-40 pubmed
    ..We hypothesize that hStnB regulates synaptic vesicle recycling by facilitating vesicle uncoating. ..
  18. Klammt C, Schwarz D, Fendler K, Haase W, Dötsch V, Bernhard F. Evaluation of detergents for the soluble expression of alpha-helical and beta-barrel-type integral membrane proteins by a preparative scale individual cell-free expression system. FEBS J. 2005;272:6024-38 pubmed
    ..Structural and functional variations of the analyzed membrane proteins are evident that correspond with the mode of expression and that depend on the supplied detergent. ..
  19. Mannan A, Boehm J, Sauter S, Rauber A, Byrne P, Neesen J, et al. Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein. Neurogenetics. 2006;7:93-103 pubmed
    ..It is interesting to note that RTN1 is localized to 14q23.1 where SPG15 locus was mapped. Therefore, we considered RTN1 as a candidate gene for the SPG15 locus, but our mutational analysis possibly excludes RTN1 as causative gene. ..
  20. Grupp L, Wolburg H, Mack A. Astroglial structures in the zebrafish brain. J Comp Neurol. 2010;518:4277-87 pubmed publisher
    ..Thus, astroglial cells in the zebrafish differ in many aspects from mammalian astrocytes. ..
  21. Bettenworth D, Buyse M, Bohm M, Mennigen R, Czorniak I, Kannengiesser K, et al. The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function. Am J Pathol. 2011;179:1230-42 pubmed publisher
    ..Furthermore, KdPT does not induce pigmentation, emphasizing the potential of this small molecule for the future treatment of IBD. ..
  22. Karbach J, Neumann A, Brand K, Wahle C, Siegel E, Maeurer M, et al. Phase I clinical trial of mixed bacterial vaccine (Coley's toxins) in patients with NY-ESO-1 expressing cancers: immunological effects and clinical activity. Clin Cancer Res. 2012;18:5449-59 pubmed publisher
    ..We propose to further explore the role of MBV as a potent immune modulator at higher dose levels and in conjunction with antigen-specific cancer vaccines. ..
  23. Moczko M, Dietmeier K, Sollner T, Segui B, Steger H, Neupert W, et al. Identification of the mitochondrial receptor complex in Saccharomyces cerevisiae. FEBS Lett. 1992;310:265-8 pubmed
    ..crassa MOM19 contained the N. crassa master receptor in addition to the yeast proteins. This demonstrates that the yeast complex is functional, and provides strong evidence that we also have identified the yeast MOM19. ..
  24. Schumann H, Holtz J, Zerkowski H, Hatzfeld M. Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression. Cardiovasc Res. 2000;45:720-8 pubmed
    ..This might contribute to an apoptosis susceptible phenotype of overloaded human myocardium. ..
  25. Zhao H, Cao Y, Grunz H. Isolation and characterization of a Xenopus gene (XMLP) encoding a MARCKS-like protein. Int J Dev Biol. 2001;45:817-26 pubmed
    ..This observation suggests that retinoic acid plays an important role in the regulation of XMLP. Our results suggest that XMLP might participate in pattern formation of the embryonic axis and the central nervous system. ..
  26. Fritz S, Weinbach N, Westermann B. Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. Mol Biol Cell. 2003;14:2303-13 pubmed
    ..Our results suggest that Mdm30 controls mitochondrial shape by regulating the steady-state level of Fzo1 and point to a connection of the ubiquitin/26S proteasome system and mitochondria. ..
  27. Althaus J, Bernaudin M, Petit E, Toutain J, Touzani O, Rami A. Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats. Neurochem Int. 2006;48:687-95 pubmed
    ..These findings open the possibility that the hypoxia-regulated pro-apoptotic protein BNIP3 enters the nucleus and could interact with other proteins involved in DNA structure, transcription or mRNA splicing after focal brain ischemia. ..
  28. Kott S, Werner M, Körber C, Hollmann M. Electrophysiological properties of AMPA receptors are differentially modulated depending on the associated member of the TARP family. J Neurosci. 2007;27:3780-9 pubmed
  29. Scholz C, Sauer G, Deissler H. Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum. Protein Pept Lett. 2009;16:1244-8 pubmed
    ..Glycosylation seemed to be required for correct folding and subsequent transition through the endoplasmic reticulum. ..
  30. Zaucke F, Boehnlein J, Steffens S, Polishchuk R, Rampoldi L, Fischer A, et al. Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression. Hum Mol Genet. 2010;19:1985-97 pubmed publisher
    ..Our data add UMOD to the group of proteins expressed in primary cilia, where mutations of the gene lead to cystic kidney disease. ..
  31. Böttcher Friebertshäuser E, Freuer C, Sielaff F, Schmidt S, Eickmann M, Uhlendorff J, et al. Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors. J Virol. 2010;84:5605-14 pubmed publisher
    ..The further development of these inhibitors could lead to new drugs for influenza treatment. ..
  32. Kamlah F, Hänze J, Arenz A, Seay U, Hasan D, Juricko J, et al. Comparison of the effects of carbon ion and photon irradiation on the angiogenic response in human lung adenocarcinoma cells. Int J Radiat Oncol Biol Phys. 2011;80:1541-9 pubmed publisher
    ..Thus, in this model system evaluating angiogenesis, carbon ion irradiation may have a therapeutic advantage. This observation should be confirmed in orthotopic lung tumor models. ..
  33. Hessner F, Dlugos C, Chehab T, Schaefer C, Homey B, Gerke V, et al. CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10. Sci Rep. 2016;6:22649 pubmed publisher
    ..This identifies S100A10 as a novel interaction partner and regulator of CCR10 that might serve as a target for therapeutic intervention. ..
  34. Huber R, Berendes R, Burger A, Schneider M, Karshikov A, Luecke H, et al. Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins. J Mol Biol. 1992;223:683-704 pubmed
    ..We suggest that annexins bind with their convex face to membranes, causing local disorder and permeability of the phospholipid bilayers. Annexins are Janus-faced proteins that face phospholipid and water and mediate calcium transport. ..
  35. Hildebrandt F, Otto E, Rensing C, Nothwang H, Vollmer M, Adolphs J, et al. A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1. Nat Genet. 1997;17:149-53 pubmed
    ..In patients with a hemizygous deletion of the NPH1 region, additional point mutations were found in NPHP1 but not in MALL. ..
  36. Takke C, Dornseifer P, v Weizsäcker E, Campos Ortega J. her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling. Development. 1999;126:1811-21 pubmed
    ..These results suggest that her4 acts as a target of notch-mediated signals that regulate primary neurogenesis. ..
  37. Huynh T, Würch A, Bruyns E, Korinek V, Schraven B, Eichmann K. Developmentally regulated expression of the transmembrane adaptor protein trim in fetal and adult T cells. Scand J Immunol. 2001;54:146-54 pubmed
    ..In fetal and adult thymocytes, TRIM protein expression was highest in DN2, DN3 (CD44-25+) and in DP cells, compatible with a functional role at or around phases of thymic selection. ..
  38. Howard S, Herrmann C, Stratilo C, Braun V. In vivo synthesis of the periplasmic domain of TonB inhibits transport through the FecA and FhuA iron siderophore transporters of Escherichia coli. J Bacteriol. 2001;183:5885-95 pubmed
  39. Rohde G, Wenzel D, Haucke V. A phosphatidylinositol (4,5)-bisphosphate binding site within mu2-adaptin regulates clathrin-mediated endocytosis. J Cell Biol. 2002;158:209-14 pubmed
    ..We suggest that PI(4,5)P2 binding to mu2-adaptin regulates clathrin-mediated endocytosis and thereby may contribute to structurally linking cargo recognition to coat formation. ..
  40. Bader I, Brandau O, Achatz H, Apfelstedt Sylla E, Hergersberg M, Lorenz B, et al. X-linked retinitis pigmentosa: RPGR mutations in most families with definite X linkage and clustering of mutations in a short sequence stretch of exon ORF15. Invest Ophthalmol Vis Sci. 2003;44:1458-63 pubmed
    ..The discrepancy of the proportion of families linked to the RP3 locus and those having RPGR mutations is resolved in a subset of families with definite X linkage. ..
  41. Juenger H, Juenger C, Holst M, Duffe K, Jankowski J, Baader S. Tetraspanin-5 (Tm4sf9) mRNA expression parallels neuronal maturation in the cerebellum of normal and L7En-2 transgenic mice. J Comp Neurol. 2005;483:318-28 pubmed
    ..Thus, the level of Tspan-5 mRNA expression correlates very well with the differentiation status of particular neurons. The level of Tspan-5 expression might therefore be important for distinct phases of neuronal maturation. ..
  42. Boedeker C, Neumann H, Ridder G, Maier W, Schipper J. Paragangliomas in patients with mutations of the SDHD gene. Otolaryngol Head Neck Surg. 2005;132:467-70 pubmed
    ..Because morbidity after surgical resection increases with tumor size, early surgery will minimize the potential risks. ..
  43. Gehrke S, Herrmann T, Kulaksiz H, Merle U, Bents K, Kaiser I, et al. Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway. Digestion. 2005;72:25-32 pubmed
    ..An HFE-independent pathway that seems to involve TFR2 and HJV can regulate HAMP expression under conditions of iron overload. ..
  44. Paarmann I, Schmitt B, Meyer B, Karas M, Betz H. Mass spectrometric analysis of glycine receptor-associated gephyrin splice variants. J Biol Chem. 2006;281:34918-25 pubmed
    ..Our data show that GlyR-associated gephyrin, lacking C3, but enriched in C4 without C5, differs from other neuronal and nonneuronal gephyrin isoforms. ..
  45. Sager C, Tapken D, Kott S, Hollmann M. Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins. Neuroscience. 2009;158:45-54 pubmed publisher
    ..The study of TARP-mediated functional plasticity of AMPA receptors, which has emerged only recently as a hot new field, promises to yield valuable insight into the regulation of neuronal communication. ..
  46. Himmerkus N, Shan Q, Goerke B, Hou J, Goodenough D, Bleich M. Salt and acid-base metabolism in claudin-16 knockdown mice: impact for the pathophysiology of FHHNC patients. Am J Physiol Renal Physiol. 2008;295:F1641-7 pubmed publisher
    ..This study has contributed to the still incomplete understanding of the symptoms of FHHNC patients. ..
  47. Nasir O, Wang K, Foller M, Gu S, Bhandaru M, Ackermann T, et al. Relative resistance of SGK1 knockout mice against chemical carcinogenesis. IUBMB Life. 2009;61:768-76 pubmed publisher
    ..SGK1 deficiency counteracts the development of colonic tumors, an effect at least in part due to up-regulation of FOXO3a and BIM. ..
  48. Koncarevic S, Rohrbach P, Deponte M, Krohne G, Prieto J, Yates J, et al. The malarial parasite Plasmodium falciparum imports the human protein peroxiredoxin 2 for peroxide detoxification. Proc Natl Acad Sci U S A. 2009;106:13323-8 pubmed publisher
    ..Under chloroquine treatment, a drug promoting oxidative stress, the abundance of hPrx-2 in the parasite increases significantly. P. falciparum has adapted to adopt the hPrx-2, thereby using the host protein for its own purposes. ..
  49. Meinecke M, Cizmowski C, Schliebs W, Krüger V, Beck S, Wagner R, et al. The peroxisomal importomer constitutes a large and highly dynamic pore. Nat Cell Biol. 2010;12:273-7 pubmed publisher
    ..The newly identified pore shows striking dynamics, as expected for an import machinery translocating proteins of variable sizes. ..
  50. Mauch C, Zamek J, Abety A, Grimberg G, Fox J, Zigrino P. Accelerated wound repair in ADAM-9 knockout animals. J Invest Dermatol. 2010;130:2120-30 pubmed publisher
    ..These results show the previously unreported role of ADAM-9 in wound repair by regulating keratinocyte migration through modulation of collagen XVII shedding...
  51. Tian Y, Kongsuphol P, Hug M, Ousingsawat J, Witzgall R, Schreiber R, et al. Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A. FASEB J. 2011;25:1058-68 pubmed publisher
    ..These results reinforce the use of these compounds for activation of electrolyte secretion in diseases such as cystic fibrosis. ..
  52. Reinhold R, Bareth B, Balleininger M, Wissel M, Rehling P, Mick D. Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast. Hum Mol Genet. 2011;20:2379-93 pubmed publisher
    ..Thus, exchanging the conserved tyrosine (Y(344)) with aspartate in yeast uncouples translational regulation of Cox1 from cytochrome c oxidase assembly and provides evidence for the dual functionality of Shy1. ..
  53. Dumke R, Hausner M, Jacobs E. Role of Mycoplasma pneumoniae glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in mediating interactions with the human extracellular matrix. Microbiology. 2011;157:2328-38 pubmed publisher
    ..Thus, the surface-exposed fraction of GAPDH may be a factor that contributes to the successful colonization of the human respiratory tract by M. pneumoniae...
  54. Schwarz H, Chang Y, Hennemann H, Dahl E, Lalley P, Willecke K. Chromosomal assignments of mouse connexin genes, coding for gap junctional proteins, by somatic cell hybridization. Somat Cell Mol Genet. 1992;18:351-9 pubmed
    ..3 have previously been assigned. Interestingly three of them (coding for Cx31, Cx31.1, and Cx30.3) are preferentially expressed in skin. Possibly some of the connexin genes clustered on mouse chromosome 4 may be regulated coordinately. ..
  55. Suppmann B, Sawers G. Isolation and characterization of hypophosphite--resistant mutants of Escherichia coli: identification of the FocA protein, encoded by the pfl operon, as a putative formate transporter. Mol Microbiol. 1994;11:965-82 pubmed
    ..coli and the FdhC protein of Methanobacterium formicicum. All three proteins are predicted to be integral membrane proteins. A detailed in vivo TnphoA mutagenesis study predicted that FocA has six membrane-spanning segments. ..
  56. Burkovski A. Rapid detection of bacterial surface proteins using an enzyme-linked immunosorbent assay system. J Biochem Biophys Methods. 1997;34:69-71 pubmed
    ..The protocol uses whole cells and avoids any centrifugation or cross-linking steps. Less than 10(6) cells were detected by this procedure...
  57. Lenhard T, Reiländer H. Engineering the folding pathway of insect cells: generation of a stably transformed insect cell line showing improved folding of a recombinant membrane protein. Biochem Biophys Res Commun. 1997;238:823-30 pubmed
  58. Kirchhoff C, Pera I, Derr P, Yeung C, Cooper T. The molecular biology of the sperm surface. Post-testicular membrane remodelling. Adv Exp Med Biol. 1997;424:221-32 pubmed
    ..Its synthesis is carefully regulated by the cells of the epididymal epithelium, with temperature and androgens acting synergistically on CD52 mRNA levels. ..
  59. Mademidis A, Koster W. Transport activity of FhuA, FhuC, FhuD, and FhuB derivatives in a system free of polar effects, and stoichiometry of components involved in ferrichrome uptake. Mol Gen Genet. 1998;258:156-65 pubmed
    ..The stoichiometry of the components involved in the uptake of iron(III) hydroxamates seems to be important for proper functioning. ..
  60. Buechler C, Ritter M, Orso E, Langmann T, Klucken J, Schmitz G. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. J Leukoc Biol. 2000;67:97-103 pubmed
    ..This expression pattern implies a functional role of CD 163 in the antiinflammatory response of monocytes. ..
  61. Ossig R, Schmitt H, de Groot B, Riedel D, Keranen S, Ronne H, et al. Exocytosis requires asymmetry in the central layer of the SNARE complex. EMBO J. 2000;19:6000-10 pubmed
    ..We conclude that the asymmetric arrangement of the polar amino acids in the central layer is essential for normal function of SNAREs in membrane fusion. ..
  62. Helbig J, Lück P, Steinert M, Jacobs E, Witt M. Immunolocalization of the Mip protein of intracellularly and extracellularly grown Legionella pneumophila. Lett Appl Microbiol. 2001;32:83-8 pubmed
    ..It can be assumed that the accumulation of Mip protein in the multilamellar host membranes increases the infection potential. ..
  63. Schlomann U, Wildeboer D, Webster A, Antropova O, Zeuschner D, Knight C, et al. The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion. J Biol Chem. 2002;277:48210-9 pubmed
    ..Our findings demonstrate that ADAM8 processing by autocatalysis leads to a potential sheddase and to a form of ADAM8 with a function in cell adhesion. ..
  64. Frazier A, Dudek J, Guiard B, Voos W, Li Y, Lind M, et al. Pam16 has an essential role in the mitochondrial protein import motor. Nat Struct Mol Biol. 2004;11:226-33 pubmed
    ..Thus, Pam16 is a newly identified type of motor subunit and is required to promote a functional PAM reaction cycle, thereby driving preprotein import into the matrix. ..
  65. Tebbe A, Klein C, Bisle B, Siedler F, Scheffer B, Garcia Rizo C, et al. Analysis of the cytosolic proteome of Halobacterium salinarum and its implication for genome annotation. Proteomics. 2005;5:168-79 pubmed
    ..The analysis of the integral membrane proteome by tandem mass spectrometric techniques added another 141 identified proteins not identified by the 2-DE approach (see following paper)...
  66. Huber Lang M, Sarma J, Rittirsch D, Schreiber H, Weiss M, Flierl M, et al. Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans. J Immunol. 2005;174:1104-10 pubmed
    ..In contrast, sepsis survivors exhibited retention of C5L2 (n = 12/13). The data suggest that C5L2 on PMN diminishes during sepsis due to systemic generation of C5a, which is associated with a poor prognosis. ..
  67. Rupec R, Jundt F, Rebholz B, Eckelt B, Weindl G, Herzinger T, et al. Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity. 2005;22:479-91 pubmed
    ..In summary, we show that cell-fate decisions leading to a premalignant hematopoietic disorder can be initiated by nonhematopoietic cells with inactive I kappa B alpha. ..
  68. Hilger D, Jung H, Padan E, Wegener C, Vogel K, Steinhoff H, et al. Assessing oligomerization of membrane proteins by four-pulse DEER: pH-dependent dimerization of NhaA Na+/H+ antiporter of E. coli. Biophys J. 2005;89:1328-38 pubmed
  69. Skriner K, Adolph K, Jungblut P, Burmester G. Association of citrullinated proteins with synovial exosomes. Arthritis Rheum. 2006;54:3809-14 pubmed
  70. BelAiba R, Djordjevic T, Petry A, Diemer K, Bonello S, Banfi B, et al. NOX5 variants are functionally active in endothelial cells. Free Radic Biol Med. 2007;42:446-59 pubmed
    ..These findings suggest that NOX5 variants play a novel role in controlling ROS-dependent processes in the vasculature. ..
  71. Glück J, Wittlich M, Feuerstein S, Hoffmann S, Willbold D, Koenig B. Integral membrane proteins in nanodiscs can be studied by solution NMR spectroscopy. J Am Chem Soc. 2009;131:12060-1 pubmed publisher
    ..Our results demonstrate that IMPs in nanodiscs are amenable to liquid-state NMR methodology. ..
  72. Erhardt A, Czibere L, Roeske D, Lucae S, Unschuld P, Ripke S, et al. TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. Mol Psychiatry. 2011;16:647-63 pubmed publisher
    ..TMEM132D may thus be an important new candidate gene for PD as well as more generally for anxiety-related behavior. ..
  73. Vandana S, Sustmann R, Rauen U, Stöhr C. FNOCT as a fluorescent probe for in vivo localization of nitric oxide distribution in tobacco roots. Plant Physiol Biochem. 2012;59:80-9 pubmed publisher
    ..Intact roots were chosen for microscopic observation rather than incised roots to avoid production of NO due to stress or physical injury. ..
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