Genomes and Genes
Experts and Doctors on membrane proteins in Belgium
Topic: membrane proteins
Publications122 found, 100 shown here
- Van Kolen K, Slegers H. P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B. J Neurochem. 2004;89:442-53 pubmed
- Christophe Hobertus C, Kooy F, Gecz J, Abramowicz M, Holinski Feder E, Schwartz C, et al. TM4SF10 gene sequencing in XLMR patients identifies common polymorphisms but no disease-associated mutation. BMC Med Genet. 2004;5:22 pubmed..We have investigated the majority of the known MRX families linked to the TM4SF10 gene region. In the absence of mutations detected, our study indicates that alterations of TM4SF10 are not a frequent cause of XLMR. ..
- Mahieu T, Park J, Revets H, Pasche B, Lengeling A, Staelens J, et al. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A. 2006;103:2292-7 pubmed..In contrast to TLR4-deficient mice, SPRET/Ei mice resist both LPS and sepsis induced with Klebsiella pneumoniae. ..
- Geukens N, Rao C V S, Mellado R, Frederix F, Reekmans G, De Keersmaeker S, et al. Surface plasmon resonance-based interaction studies reveal competition of Streptomyces lividans type I signal peptidases for binding preproteins. Microbiology. 2006;152:1441-50 pubmed..Hence, these results strongly suggest that there are additional factors other than the cleavage requirements of the enzymes that strongly affect the substrate preference of SPases in vivo. ..
- Vanherberghen M, Bureau F, Peters I, Day M, Clercx C, Peeters D. Analysis of gene expression in canine sino-nasal aspergillosis and idiopathic lymphoplasmacytic rhinitis: a transcriptomic analysis. Vet Microbiol. 2012;157:143-51 pubmed publisher..The over-expression of interleukin (IL)-16, natural killer cell group 7 and chemokine ligand 10 might be related to a potential protective Th1 immunity counterbalanced by other molecules such as DNA-binding protein Ikaros...
- Dejeans N, Glorieux C, Guenin S, Beck R, Sid B, Rousseau R, et al. Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence. Free Radic Biol Med. 2012;52:993-1002 pubmed publisher..In conclusion, this study suggests that GRP94 overexpression may be a hallmark of aggressiveness and recurrence in breast cancers. ..
- Pontes M, Van Waesberghe C, Nauwynck H, Verhasselt B, Favoreel H. Pseudorabies virus glycoprotein gE triggers ERK1/2 phosphorylation and degradation of the pro-apoptotic protein Bim in epithelial cells. Virus Res. 2016;213:214-218 pubmed publisher..Our results for the first time link the viral glycoprotein gE, an important alphaherpesvirus virulence factor, with the apoptotic signaling pathway. ..
- Sánchez Vásquez L, Vázquez Acevedo M, De La Mora J, Vega deLuna F, Cardol P, Remacle C, et al. Near-neighbor interactions of the membrane-embedded subunits of the mitochondrial ATP synthase of a chlorophycean alga. Biochim Biophys Acta Bioenerg. 2017;1858:497-509 pubmed publisher..We also propose based on sequence analysis and hydrophobicity plots, that the algal subunit a is atypical in as much it lacks the first transmembrane stretch, exhibiting only four hydrophobic, tilted alpha helices. ..
- Marynen P, Zhang J, Cassiman J, Van den Berghe H, David G. Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell . J Biol Chem. 1989;264:7017-24 pubmed..The 48K5 gene was mapped to chromosome 8q23 by in situ hybridization and hybridization to DNA of somatic cell hybrids. ..
- Debeer P, Schoenmakers E, Thoelen R, Holvoet M, Kuittinen T, Fabry G, et al. Physical map of a 1.5 mb region on 12p11.2 harbouring a synpolydactyly associated chromosomal breakpoint. Eur J Hum Genet. 2000;8:561-70 pubmed..These findings lay the groundwork for further efforts to characterise a gene critical for normal distal limb development that is perturbed by this translocation. ..
- Dewachter I, Van Dorpe J, Smeijers L, Gilis M, Kuiperi C, Laenen I, et al. Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1. J Neurosci. 2000;20:6452-8 pubmed..Therefore, the data are interpreted to suggest that parenchymal and vascular accumulation of amyloid in aging brain resulted from failure to clear the amyloid peptides rather than from increased production. ..
- Vertommen A, Panis B, Swennen R, Carpentier S. Challenges and solutions for the identification of membrane proteins in non-model plants. J Proteomics. 2011;74:1165-81 pubmed publisher..Finally, an overview of recent plant membrane proteome studies is provided with the used separation technique and the number of identified membrane proteins listed. ..
- Jacquet A, Daminet V, Haumont M, Garcia L, Chaudoir S, Bollen A, et al. Expression of a recombinant Toxoplasma gondii ROP2 fragment as a fusion protein in bacteria circumvents insolubility and proteolytic degradation. Protein Expr Purif. 1999;17:392-400 pubmed..Such fusions could represent an alternative to study the immunogenicity of T. gondii proteins which are difficult to produce because of insolubility and degradation...
- Piette A, Fraipont C, Den Blaauwen T, Aarsman M, Pastoret S, Nguyen Distèche M. Structural determinants required to target penicillin-binding protein 3 to the septum of Escherichia coli. J Bacteriol. 2004;186:6110-7 pubmed..We postulate that FtsQ could play a role in regulating the assembly of these division proteins at the division site and the activity of the peptidoglycan assembly machineries within the divisome. ..
- Van den Plas D, Merregaert J. In vitro studies on Itm2a reveal its involvement in early stages of the chondrogenic differentiation pathway. Biol Cell. 2004;96:463-70 pubmed..These results demonstrate that overexpression of Itm2a in mouse ATDC5 cells impede the transition to hypertrophic cells. Taken together, our observation supports the involvement of Itm2a in the early stages of chondrogenesis in vitro. ..
- Vrijens K, Thys S, De Jeu M, Postnov A, Pfister M, Cox L, et al. Ozzy, a Jag1 vestibular mouse mutant, displays characteristics of Alagille syndrome. Neurobiol Dis. 2006;24:28-40 pubmed..Thirty-seven percent of Ozzy mice showed heart defects. No eye or vertebral abnormalities could be detected. In conclusion, Ozzy mice show two of the major and one minor characteristic of AGS...
- De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 1998;391:387-90 pubmed..Our results indicate that mutations in PS1 that manifest clinically cause a gain of function and that inhibition of PS1 activity is a potential target for anti-amyloidogenic therapy in Alzheimer's disease. ..
- Baert B, Baysse C, Matthijs S, Cornelis P. Multiple phenotypic alterations caused by a c-type cytochrome maturation ccmC gene mutation in Pseudomonas aeruginosa. Microbiology. 2008;154:127-38 pubmed publisher..In conclusion, we have demonstrated that CcmC is a key determinant for cytochrome c biogenesis, pyoverdine maturation, and expression of some quorum sensing-regulated traits...
- De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm J, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999;398:518-22 pubmed..Thus the targeting of gamma-secretase for the treatment of Alzheimer's disease may risk toxicity caused by reduced Notch signalling. ..
- Ghys K, Fransen M, Mannaerts G, Van Veldhoven P. Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins. Biochem J. 2002;365:41-50 pubmed..The GFP fusion proteins, tagged at either the N- or C-terminus, were able to restore PTS2 import in rhizomelic chondrodysplasia punctata fibroblasts, and Pex7p-GFP was located both in the lumen of peroxisomes and in the cytosol...
- Vertommen A, Møller A, Cordewener J, Swennen R, Panis B, Finnie C, et al. A workflow for peptide-based proteomics in a poorly sequenced plant: a case study on the plasma membrane proteome of banana. J Proteomics. 2011;74:1218-29 pubmed publisher..By applying this workflow, integral plasma membrane proteins from banana leaves were successfully identified. ..
- Roebroek A, Contreras B, Pauli I, Van de Ven W. cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons. Genomics. 1998;51:98-106 pubmed..Analysis of the expression of the RTN2 gene shows differential expression in human tissues with a strikingly high expression of the 1.3-kb transcript in skeletal muscle. ..
- Govaerts C, Lefort A, Costagliola S, Wodak S, Ballesteros J, Van Sande J, et al. A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor. J Biol Chem. 2001;276:22991-9 pubmed..In the TSHr, the conformation of this Asn residue of TM7 would be constrained, in the inactive state, by its Asp partner in TM6. ..
- Menten B, Buysse K, Zahir F, Hellemans J, Hamilton S, Costa T, et al. Osteopoikilosis, short stature and mental retardation as key features of a new microdeletion syndrome on 12q14. J Med Genet. 2007;44:264-8 pubmed..The observation of osteopoikilosis lesions should facilitate recognition of this new microdeletion syndrome among children with failure to thrive, short stature and learning disabilities...
- De Smedt M, Leclercq G, Vandekerckhove B, Kerre T, Taghon T, Plum J. T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells. Haematologica. 2011;96:646-54 pubmed publisher..Our data shows that cord blood hematopoietic stem cells have higher T-lymphoid differentiation potential than bone marrow hematopoietic stem cells and that this property is cell autonomous. ..
- Octave J, Essalmani R, Tasiaux B, Menager J, Czech C, Mercken L. The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease. J Biol Chem. 2000;275:1525-8 pubmed..Taken together, these results conclusively show that, although PS1 does not cleave APP in Sf9 cells, PS1 allows the secretion of Abeta without endocytosis of APP by CHO cells. ..
- Lammertyn E, Van Mellaert L, Meyen E, Lebeau I, De Buck E, Anne J, et al. Molecular and functional characterization of type I signal peptidase from Legionella pneumophila. Microbiology. 2004;150:1475-83 pubmed..Finally it was shown by in vivo experiments that L. pneumophila LepB is a target for (5S,6S)-6-[(R)-acetoxyethyl]-penem-3-carboxylate, a specific inhibitor of type I SPases. ..
- Navet R, Douette P, Puttine Marique F, Sluse Goffart C, Jarmuszkiewicz W, Sluse F. Regulation of uncoupling protein activity in phosphorylating potato tuber mitochondria. FEBS Lett. 2005;579:4437-42 pubmed..We propose that in phosphorylating potato tuber mitochondria, the redox state of ubiquinone, which can antagonistically be varied with AA and nBM, modulates inhibition of the PA-activated UCP-sustained H+ leak by GTP. ..
- Boyen F, Pasmans F, Donne E, Van Immerseel F, Adriaensen C, Hernalsteens J, et al. Role of SPI-1 in the interactions of Salmonella Typhimurium with porcine macrophages. Vet Microbiol. 2006;113:35-44 pubmed..SPI-1 dependent invasion, however, is not a prerequisite to induce a pro-inflammatory response. ..
- Bettendorff L, Hennuy B, Wins P, Schoffeniels E. Thiamin and derivatives as modulators of rat brain chloride channels. Neuroscience. 1993;52:1009-17 pubmed..1 mM veratridine (which should both result in membrane depolarization) increased 36Cl- uptake by 50 and 30% respectively; the inhibitory effect of oxythiamin was enhanced to the same proportion.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Ledent P, Duez C, Vanhove M, Lejeune A, Fonz E, Charlier P, et al. Unexpected influence of a C-terminal-fused His-tag on the processing of an enzyme and on the kinetic and folding parameters. FEBS Lett. 1997;413:194-6 pubmed..This resulted in the secretion of a protein with a different N-terminus, showing that this type of protein engineering might not always be as 'neutral' as generally assumed...
- Victoir K, Arevalo J, De Doncker S, Barker D, Laurent T, Godfroid E, et al. Complexity of the major surface protease (msp) gene organization in Leishmania (Viannia) braziliensis: evolutionary and functional implications. Parasitology. 2005;131:207-14 pubmed..We speculate that this would be an adaptive strategy of the parasite. ..
- Decottignies A, Evain A, Ghislain M. Binding of Cdc48p to a ubiquitin-related UBX domain from novel yeast proteins involved in intracellular proteolysis and sporulation. Yeast. 2004;21:127-39 pubmed..Together, these results indicate that the Cuil-3 proteins form complexes that are components of the ubiquitin-proteasome system. ..
- Wawrzyniak A, Vermeiren E, Zimmermann P, Ivarsson Y. Extensions of PSD-95/discs large/ZO-1 (PDZ) domains influence lipid binding and membrane targeting of syntenin-1. FEBS Lett. 2012;586:1445-51 pubmed publisher..Our study adds new components to the multi-dentate membrane targeting mechanism and highlights the role of N- and C-terminal PDZ extensions in the regulation of syntenin-1 plasma membrane localization. ..
- Goffin C, Fraipont C, Ayala J, Terrak M, Nguyen Distèche M, Ghuysen J. The non-penicillin-binding module of the tripartite penicillin-binding protein 3 of Escherichia coli is required for folding and/or stability of the penicillin-binding module and the membrane-anchoring module confers cell septation activity on the fo. J Bacteriol. 1996;178:5402-9 pubmed..The in vivo activity of PBP3 also depends on the M-1-to-E-56 amino-terminal module which encompasses the cytosol, the membrane, and the periplasm and which functions as a noncleaved pseudo-signal peptide. ..
- Stiernet P, Nenquin M, Moulin P, Jonas J, Henquin J. Glucose-induced cytosolic pH changes in beta-cells and insulin secretion are not causally related: studies in islets lacking the Na+/H+ exchangeR NHE1. J Biol Chem. 2007;282:24538-46 pubmed..The changes in pH(c) produced by glucose involve HCO(-)(3)-dependent mechanisms. Variations in beta-cell pH(c) are not causally related to changes in insulin secretion. ..
- Deleersnijder W, Hong G, Cortvrindt R, Poirier C, Tylzanowski P, Pittois K, et al. Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins. J Biol Chem. 1996;271:19475-82 pubmed..Homology searches of DNA databanks showed that E25 belongs to a novel multigene family, containing three members both in man and mouse. The mouse E25 gene locus (Itm2) was mapped to the X chromosome. ..
- Belles Boix E, Babiychuk E, Montagu M, Inze D, Kushnir S. CEF, a sec24 homologue of Arabidopsis thaliana, enhances the survival of yeast under oxidative stress conditions. J Exp Bot. 2000;51:1761-2 pubmed..CEF is homologous to animal and yeast Sec24 proteins. These data suggest that CEF plays a protective role through protein transport during growth under pro-oxidant conditions. ..
- Van Kolen K, Gilany K, Moens L, Esmans E, Slegers H. P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1. Cell Signal. 2006;18:1169-81 pubmed
- Fransen M, Vastiau I, Brees C, Brys V, Mannaerts G, Van Veldhoven P. Potential role for Pex19p in assembly of PTS-receptor docking complexes. J Biol Chem. 2004;279:12615-24 pubmed..Importantly, we also found that amino acid substitutions resulting in a strongly reduced binding affinity for Pex13p affect the peroxisomal localization of Pex14p. ..
- Geukens N, Frederix F, Reekmans G, Lammertyn E, Van Mellaert L, Dehaen W, et al. Analysis of type I signal peptidase affinity and specificity for preprotein substrates. Biochem Biophys Res Commun. 2004;314:459-67 pubmed..In fact, this is the first report of a membrane protein that was covalently attached to a biosensor surface and that retained binding capacity. ..
- Grootjans J, Reekmans G, Ceulemans H, David G. Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin. J Biol Chem. 2000;275:19933-41 pubmed..In general, an intramolecular combination of PDZ domains that are weak, taken individually, would appear to be designed to detect rather than drive the formation of specific molecular assemblies. ..
- Jacquet A, Coulon L, De Neve J, Daminet V, Haumont M, Garcia L, et al. The surface antigen SAG3 mediates the attachment of Toxoplasma gondii to cell-surface proteoglycans. Mol Biochem Parasitol. 2001;116:35-44 pubmed..Taken together, these results indicate that SAG3 is a first glycoaminoglycan-binding protein associated with Toxoplasma, and SAG3-HSPGs interactions are involved in the parasite attachment to target cells. ..
- Nilius B, Prenen J, Hoenderop J, Vennekens R, Hoefs S, Weidema A, et al. Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3. J Biol Chem. 2002;277:30852-8 pubmed..In conclusion, the TM2-TM3 loop is a critical determinant of the inactivation in ECaC1 and ECaC2. ..
- Baeyens N, Latrache I, Yerna X, Noppe G, Horman S, Morel N. Redundant control of migration and adhesion by ERM proteins in vascular smooth muscle cells. Biochem Biophys Res Commun. 2013;441:579-85 pubmed publisher..These results indicate that ERM proteins exert a redundant control on PDGF-induced VSMC migration by regulating focal adhesion turn-over and cell adhesion to substrate. ..
- Vervoort M, Merritt D, Ghysen A, Dambly Chaudiere C. Genetic basis of the formation and identity of type I and type II neurons in Drosophila embryos. Development. 1997;124:2819-28 pubmed
- Herman C, Thevenet D, Bouloc P, Walker G, D Ari R. Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH). Genes Dev. 1998;12:1348-55 pubmed..These results establish a tail-specific pathway for removing abnormal cytoplasmic proteins via the HflB and Clp proteases. ..
- Flamez D, Berger V, Kruhøffer M, Orntoft T, Pipeleers D, Schuit F. Critical role for cataplerosis via citrate in glucose-regulated insulin release. Diabetes. 2002;51:2018-24 pubmed
- Hendrickx N, Volanti C, Moens U, Seternes O, de Witte P, Vandenheede J, et al. Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. J Biol Chem. 2003;278:52231-9 pubmed
- Nijsten T, Geluyckens E, Colpaert C, Lambert J. Peroxisome proliferator-activated receptors in squamous cell carcinoma and its precursors. J Cutan Pathol. 2005;32:340-7 pubmed..Although further research is warranted, these results suggest that PPAR ligands such as fibrates and thiazolidinediones may have chemoprophylactic properties in skin carcinogenesis. ..
- Nilius B, Prenen J, Janssens A, Owsianik G, Wang C, Zhu M, et al. The selectivity filter of the cation channel TRPM4. J Biol Chem. 2005;280:22899-906 pubmed..Our findings delineate the selectivity filter of TRPM channels and provide the first insight into the molecular basis of monovalent cation selectivity. ..
- Wawrzak D, Metioui M, Willems E, Hendrickx M, De Genst E, Leyns L. Wnt3a binds to several sFRPs in the nanomolar range. Biochem Biophys Res Commun. 2007;357:1119-23 pubmed..These results provide the first measurement of binding affinity of sFRPs for a Wnt, which together with the measurement of antagonistic activity of sFRPs could help understand how sFRPs regulate Wnt signaling. ..
- Li T, Froeyen M, Herdewijn P. Computational alanine scanning and free energy decomposition for E. coli type I signal peptidase with lipopeptide inhibitor complex. J Mol Graph Model. 2008;26:813-23 pubmed..coli SPase are also analyzed. This study can be a guide for the optimization of lipopeptide inhibitors and future design of new therapeutic agents for the treatment of bacterial infections. ..
- Henno A, Blacher S, Lambert C, Deroanne C, Noel A, Lapiere C, et al. Histological and transcriptional study of angiogenesis and lymphangiogenesis in uninvolved skin, acute pinpoint lesions and established psoriasis plaques: an approach of vascular development chronology in psoriasis. J Dermatol Sci. 2010;57:162-9 pubmed publisher..Expansion of BV in PP could be followed by vessel enlargement during progression to PSO, in parallel with a decreased VEGF-A 189/VEGF-A 121 balance in plaques. ..
- Boudin E, Piters E, Fransen E, Nielsen T, Andersen M, Roef G, et al. Association study of common variants in the sFRP1 gene region and parameters of bone strength and body composition in two independent healthy Caucasian male cohorts. Mol Genet Metab. 2012;105:508-15 pubmed publisher..However we were not able to replicate those results in the Belgian population. At last we found in the OAS population age specific effects for rs10106678 with whole body BMD and waist to hip ratio. ..
- Van Heirstraeten L, Coenen S, Lammens C, Hens N, Goossens H, Malhotra Kumar S. Antimicrobial drug use and macrolide-resistant Streptococcus pyogenes, Belgium. Emerg Infect Dis. 2012;18:1515-8 pubmed publisher..Maintaining drug use below a critical threshold corresponded with low-level macrolide-resistant S. pyogenes and an increased number of erm(A)-harboring emm77 S. pyogenes with low fitness costs...
- Van de Walle I, Waegemans E, De Medts J, De Smet G, De Smedt M, Snauwaert S, et al. Specific Notch receptor-ligand interactions control human TCR-??/?? development by inducing differential Notch signal strength. J Exp Med. 2013;210:683-97 pubmed publisher..Our findings reveal that differential Notch receptor-ligand interactions mediate human TCR-?? and -?? T cell differentiation and provide a mechanistic insight into the high Notch dependency of human ?? T cell development. ..
- Dedobbeleer O, Stockis J, van der Woning B, Coulie P, Lucas S. Cutting Edge: Active TGF-?1 Released from GARP/TGF-?1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA. J Immunol. 2017;199:391-396 pubmed publisher..We show in this study that stimulated, human B lymphocytes produce active TGF-?1 from surface GARP/latent TGF-?1 complexes with isotype switching to IgA production. ..
- Van Huffel C, Dubois E, Messenguy F. Cloning and sequencing of Schizosaccharomyces pombe car1 gene encoding arginase. Expression of the arginine anabolic and catabolic genes in response to arginine and related metabolites. Yeast. 1994;10:923-33 pubmed..cerevisiae, and also indicates that in S. pombe enzyme compartmentation is not always sufficient to control the arginine metabolic flux. ..
- Deconinck N, Rafael J, Beckers Bleukx G, Kahn D, Deconinck A, Davies K, et al. Consequences of the combined deficiency in dystrophin and utrophin on the mechanical properties and myosin composition of some limb and respiratory muscles of the mouse. Neuromuscul Disord. 1998;8:362-70 pubmed..Moreover these results bring some support to the idea that the expression of utrophin in mdx muscle compensates, to some extent, for the lack of dystrophin. ..
- Al Mariri A, Tibor A, Mertens P, De Bolle X, Michel P, Godefroid J, et al. Protection of BALB/c mice against Brucella abortus 544 challenge by vaccination with bacterioferritin or P39 recombinant proteins with CpG oligodeoxynucleotides as adjuvant. Infect Immun. 2001;69:4816-22 pubmed..Intriguingly, no protection was detected after BFR vaccination. All other groups did not demonstrate any protection. ..
- Garbacki N, Angenot L, Bassleer C, Damas J, Tits M. Effects of prodelphinidins isolated from Ribes nigrum on chondrocyte metabolism and COX activity. Naunyn Schmiedebergs Arch Pharmacol. 2002;365:434-41 pubmed..However, the prodelphinidins had no effects on COX activity in the whole blood assay. Our studies suggest that the prodelphinidins fractions from R. nigrum may be useful as an additive agent in the prevention of osteoarthritis...
- Van Laethem F, Liang X, Andris F, Urbain J, Vandenbranden M, Ruysschaert J, et al. Glucocorticoids alter the lipid and protein composition of membrane rafts of a murine T cell hybridoma. J Immunol. 2003;170:2932-9 pubmed
- Hellemans J, Preobrazhenska O, Willaert A, Debeer P, Verdonk P, Costa T, et al. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. Nat Genet. 2004;36:1213-8 pubmed..XMAN1, the Xenopus laevis ortholog, antagonizes BMP signaling during embryogenesis. In this study, LEMD3 interacted with BMP and activin-TGFbeta receptor-activated Smads and antagonized both signaling pathways in human cells...
- Fretin D, Fauconnier A, K hler S, Halling S, L onard S, Nijskens C, et al. The sheathed flagellum of Brucella melitensis is involved in persistence in a murine model of infection. Cell Microbiol. 2005;7:687-98 pubmed publisher..In contrast, all these mutants were unable to establish a chronic infection in mice infected via the intraperitoneal route, raising the question of the biological role(s) of this flagellar appendage...
- Van Maldergem L, Moser A, Vincent M, Roland D, Reding R, Otte J, et al. Orthotopic liver transplantation from a living-related donor in an infant with a peroxisome biogenesis defect of the infantile Refsum disease type. J Inherit Metab Dis. 2005;28:593-600 pubmed..Abnormal bile acids disappeared from plasma. Although the OLT did not result in a cure of the disorder, the clinical and biochemical results suggest that OLT should be considered in mildly symptomatic patients...
- Hellemans J, Debeer P, Wright M, Janecke A, Kjaer K, Verdonk P, et al. Germline LEMD3 mutations are rare in sporadic patients with isolated melorheostosis. Hum Mutat. 2006;27:290 pubmed..Somatic mosaicism for a LEMD3 mutation in the latter group was also not observed, and therefore we must conclude that the genetic defect in the majority of sporadic and isolated melorheostosis remains unknown...
- Van Campenhout C, Nichane M, Antoniou A, Pendeville H, Bronchain O, Marine J, et al. Evi1 is specifically expressed in the distal tubule and duct of the Xenopus pronephros and plays a role in its formation. Dev Biol. 2006;294:203-19 pubmed..Together, these data indicate that Evi1 plays a role in the proximo-distal patterning of the pronephros and suggest that it may do so by functioning as a CtBP dependent repressor. ..
- Verhoeven K, Claeys K, Zuchner S, Schröder J, Weis J, Ceuterick C, et al. MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2. Brain. 2006;129:2093-102 pubmed..In patients with a documented family history of CMT2 the frequency of MFN2 mutations was 33% indicating that MFN2 mutations are a major cause in this population...
- Hilgert N, Alasti F, Dieltjens N, Pawlik B, Wollnik B, Uyguner O, et al. Mutation analysis of TMC1 identifies four new mutations and suggests an additional deafness gene at loci DFNA36 and DFNB7/11. Clin Genet. 2008;74:223-32 pubmed publisher..The analysis of copy number variations in TMC1 as well as DNA sequencing of 15 additional candidate genes did not reveal any proven pathogenic changes, leaving both hypotheses open. ..
- Nichane M, Ren X, Souopgui J, Bellefroid E. Hairy2 functions through both DNA-binding and non DNA-binding mechanisms at the neural plate border in Xenopus. Dev Biol. 2008;322:368-80 pubmed publisher..Together, these results suggest that Hairy2 has a dual mode of action and may function at the neural plate border through both a DNA-binding and a non-DNA-binding Stat3-Delta1 mediated mechanism. ..
- Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss K, et al. ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. J Biol Chem. 2009;284:11738-47 pubmed publisher..Thus, ADAM10 performs a dual role in cells, as a metalloprotease when it is membrane-bound, and as a potential signaling protein once cleaved by ADAM9/15 and the gamma-Secretase. ..
- Renard H, Demaegd D, Guerriat B, Morsomme P. Efficient ER exit and vacuole targeting of yeast Sna2p require two tyrosine-based sorting motifs. Traffic. 2010;11:931-46 pubmed publisher..Sna2p is the first yeast protein in which two YXXØ motifs have been identified and both were shown to be functional at two different steps of the secretory pathway, ER exit and Golgi-to-vacuole transport. ..
- Bultynck G, Kiviluoto S, Henke N, Ivanova H, Schneider L, Rybalchenko V, et al. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. J Biol Chem. 2012;287:2544-57 pubmed publisher..Remarkably, one of these residues was not conserved among plant and yeast BI-1 orthologs, indicating that the ER Ca(2+)-leak properties of BI-1 are an added function during evolution...
- Verrijken A, Beckers S, Francque S, Hilden H, Caron S, Zegers D, et al. A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population. Obesity (Silver Spring). 2013;21:2138-45 pubmed publisher..No association between APOC3 gene variant rs2854117 and histological or metabolic parameters of NAFLD was found. ..
- Bettendorff L, Longrée I, Wins P, Schoffeniels E. Solubilization of thiamine triphosphatase from the electric organ of Electrophorus electricus. Biochim Biophys Acta. 1991;1073:69-76 pubmed..0, but denaturation becomes rapid at pH greater than or equal to 7. Solubilization modifies anion effects on TTPase activity. The activating effect of nitrate is nearly lost, while inhibition by sulfate is no longer time-dependent...
- Deblandre G, Marinx O, Evans S, Majjaj S, Leo O, Caput D, et al. Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. J Biol Chem. 1995;270:23860-6 pubmed
- Van Gysel A, Van Montagu M, Inze D. A negatively light-regulated gene from Arabidopsis thaliana encodes a protein showing high similarity to blue copper-binding proteins. Gene. 1993;136:79-85 pubmed..The isolation of a novel negatively photoregulated gene allows us to investigate the complex expression profile of genes responding to the absence of light. ..
- Van de Craen M, De Jonghe C, Van den Brande I, Declercq W, Van Gassen G, Van Criekinge W, et al. Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases. FEBS Lett. 1999;445:149-54 pubmed..None of five missense mutations affected the sensitivity of PSI to caspase-mediated cleavage. This suggests that AD pathogenesis associated with PS1 missense mutations cannot be explained by a change in caspase-dependent processing. ..
- Desrumaux C, Labeur C, Verhee A, Tavernier J, Vandekerckhove J, Rosseneu M, et al. A hydrophobic cluster at the surface of the human plasma phospholipid transfer protein is critical for activity on high density lipoproteins. J Biol Chem. 2001;276:5908-15 pubmed..Based on these results, we propose that a functional solvent-exposed hydrophobic cluster in the PLTP molecule specifically contributes to the PLTP transfer activity on HDL substrates. ..
- Annaert W, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, et al. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. Neuron. 2001;32:579-89 pubmed..Our data surprisingly indicate a spatial dissociation between the binding site and the proposed catalytic site near the critical aspartates in PSs. They provide important experimental evidence to support a ring structure model for PS. ..
- Tournoy J, Bossuyt X, Snellinx A, Regent M, Garmyn M, Serneels L, et al. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. Hum Mol Genet. 2004;13:1321-31 pubmed..Skin and immune system appear to be especially sensitive targets of impaired PS function and may need careful monitoring if gamma-secretase inhibitors are envisaged for treating AD. ..
- Abdel Sater F, El Bakkoury M, Urrestarazu A, Vissers S, Andre B. Amino acid signaling in yeast: casein kinase I and the Ssy5 endoprotease are key determinants of endoproteolytic activation of the membrane-bound Stp1 transcription factor. Mol Cell Biol. 2004;24:9771-85 pubmed..Upon detection of external amino acids, Ssy1-Ptr3 likely allows-in a manner dependent on SCF(Grr1)-the Ssy5 endoprotease to gain access to and to cleave Stp1, this requiring prior phosphorylation of Stp1 by casein kinase I. ..