Experts and Doctors on membrane proteins in Belgium

Summary

Locale: Belgium
Topic: membrane proteins

Top Publications

  1. Decottignies A, Lambert L, Catty P, Degand H, Epping E, Moye Rowley W, et al. Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane. J Biol Chem. 1995;270:18150-7 pubmed
  2. Kolaczkowski M, van der Rest M, Cybularz Kolaczkowska A, Soumillion J, Konings W, Goffeau A. Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p. J Biol Chem. 1996;271:31543-8 pubmed
    ..Our experimental system opens new possibilities for the analysis of structure-function relationship of multidrug transporter substrates and inhibitors...
  3. Nelissen B, De Wachter R, Goffeau A. Classification of all putative permeases and other membrane plurispanners of the major facilitator superfamily encoded by the complete genome of Saccharomyces cerevisiae. FEMS Microbiol Rev. 1997;21:113-34 pubmed
    ..The latter resulted in the identification of 21 subclusters with presumably tightly related permease function. No functional clues were predicted for a total of 41 clustered or unclustered proteins. ..
  4. Nguyen Distèche M, Fraipont C, Buddelmeijer N, Nanninga N. The structure and function of Escherichia coli penicillin-binding protein 3. Cell Mol Life Sci. 1998;54:309-16 pubmed
    ..Initiation of septum formation is not PBP3-dependent but rests on the appearance of the FtsZ ring, and is thus penicillin-insensitive. The control of PBP3 activity during the cell cycle is briefly discussed. ..
  5. Fransen M, Wylin T, Brees C, Mannaerts G, Van Veldhoven P. Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences. Mol Cell Biol. 2001;21:4413-24 pubmed
  6. Geldhof P, Claerebout E, Knox D, Vercauteren I, Looszova A, Vercruysse J. Vaccination of calves against Ostertagia ostertagi with cysteine proteinase enriched protein fractions. Parasite Immunol. 2002;24:263-70 pubmed
    ..However, these correlations were quite weak and did not appear to be isotype-specific...
  7. van Eyll O, Michiels T. Non-AUG-initiated internal translation of the L* protein of Theiler's virus and importance of this protein for viral persistence. J Virol. 2002;76:10665-73 pubmed
    ..The expression of the 18-kDa form is required for efficient persistence of DA virus derivatives in the central nervous system. ..
  8. Kaletta T, Van der Craen M, Van Geel A, Dewulf N, Bogaert T, Branden M, et al. Towards understanding the polycystins. Nephron Exp Nephrol. 2003;93:e9-17 pubmed
  9. Depreter M, Walker T, De Smet K, Beken S, Kerckaert I, Rogiers V, et al. Hepatocyte polarity and the peroxisomal compartment: a comparative study. Histochem J. 2002;34:139-51 pubmed
    ..Distinct polarization characteristics do not necessarily change simultaneously, suggesting different regulatory mechanisms. ..

More Information

Publications122 found, 100 shown here

  1. Van Kolen K, Slegers H. P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B. J Neurochem. 2004;89:442-53 pubmed
  2. Christophe Hobertus C, Kooy F, Gecz J, Abramowicz M, Holinski Feder E, Schwartz C, et al. TM4SF10 gene sequencing in XLMR patients identifies common polymorphisms but no disease-associated mutation. BMC Med Genet. 2004;5:22 pubmed
    ..We have investigated the majority of the known MRX families linked to the TM4SF10 gene region. In the absence of mutations detected, our study indicates that alterations of TM4SF10 are not a frequent cause of XLMR. ..
  3. Mahieu T, Park J, Revets H, Pasche B, Lengeling A, Staelens J, et al. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A. 2006;103:2292-7 pubmed
    ..In contrast to TLR4-deficient mice, SPRET/Ei mice resist both LPS and sepsis induced with Klebsiella pneumoniae. ..
  4. Geukens N, Rao C V S, Mellado R, Frederix F, Reekmans G, De Keersmaeker S, et al. Surface plasmon resonance-based interaction studies reveal competition of Streptomyces lividans type I signal peptidases for binding preproteins. Microbiology. 2006;152:1441-50 pubmed
    ..Hence, these results strongly suggest that there are additional factors other than the cleavage requirements of the enzymes that strongly affect the substrate preference of SPases in vivo. ..
  5. Ivarsson Y, Wawrzyniak A, Wuytens G, Kosloff M, Vermeiren E, Raport M, et al. Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulin. J Biol Chem. 2011;286:44669-78 pubmed publisher
  6. Vanherberghen M, Bureau F, Peters I, Day M, Clercx C, Peeters D. Analysis of gene expression in canine sino-nasal aspergillosis and idiopathic lymphoplasmacytic rhinitis: a transcriptomic analysis. Vet Microbiol. 2012;157:143-51 pubmed publisher
    ..The over-expression of interleukin (IL)-16, natural killer cell group 7 and chemokine ligand 10 might be related to a potential protective Th1 immunity counterbalanced by other molecules such as DNA-binding protein Ikaros...
  7. Dejeans N, Glorieux C, Guenin S, Beck R, Sid B, Rousseau R, et al. Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence. Free Radic Biol Med. 2012;52:993-1002 pubmed publisher
    ..In conclusion, this study suggests that GRP94 overexpression may be a hallmark of aggressiveness and recurrence in breast cancers. ..
  8. Demaegd D, Foulquier F, Colinet A, Gremillon L, Legrand D, Mariot P, et al. Newly characterized Golgi-localized family of proteins is involved in calcium and pH homeostasis in yeast and human cells. Proc Natl Acad Sci U S A. 2013;110:6859-64 pubmed publisher
  9. Pontes M, Van Waesberghe C, Nauwynck H, Verhasselt B, Favoreel H. Pseudorabies virus glycoprotein gE triggers ERK1/2 phosphorylation and degradation of the pro-apoptotic protein Bim in epithelial cells. Virus Res. 2016;213:214-218 pubmed publisher
    ..Our results for the first time link the viral glycoprotein gE, an important alphaherpesvirus virulence factor, with the apoptotic signaling pathway. ..
  10. Sánchez Vásquez L, Vázquez Acevedo M, De La Mora J, Vega deLuna F, Cardol P, Remacle C, et al. Near-neighbor interactions of the membrane-embedded subunits of the mitochondrial ATP synthase of a chlorophycean alga. Biochim Biophys Acta Bioenerg. 2017;1858:497-509 pubmed publisher
    ..We also propose based on sequence analysis and hydrophobicity plots, that the algal subunit a is atypical in as much it lacks the first transmembrane stretch, exhibiting only four hydrophobic, tilted alpha helices. ..
  11. Marynen P, Zhang J, Cassiman J, Van den Berghe H, David G. Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell . J Biol Chem. 1989;264:7017-24 pubmed
    ..The 48K5 gene was mapped to chromosome 8q23 by in situ hybridization and hybridization to DNA of somatic cell hybrids. ..
  12. Debeer P, Schoenmakers E, Thoelen R, Holvoet M, Kuittinen T, Fabry G, et al. Physical map of a 1.5 mb region on 12p11.2 harbouring a synpolydactyly associated chromosomal breakpoint. Eur J Hum Genet. 2000;8:561-70 pubmed
    ..These findings lay the groundwork for further efforts to characterise a gene critical for normal distal limb development that is perturbed by this translocation. ..
  13. Dewachter I, Van Dorpe J, Smeijers L, Gilis M, Kuiperi C, Laenen I, et al. Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1. J Neurosci. 2000;20:6452-8 pubmed
    ..Therefore, the data are interpreted to suggest that parenchymal and vascular accumulation of amyloid in aging brain resulted from failure to clear the amyloid peptides rather than from increased production. ..
  14. Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, et al. Alzheimer's-Causing Mutations Shift A? Length by Destabilizing ?-Secretase-A?n Interactions. Cell. 2017;170:443-456.e14 pubmed publisher
  15. Vertommen A, Panis B, Swennen R, Carpentier S. Challenges and solutions for the identification of membrane proteins in non-model plants. J Proteomics. 2011;74:1165-81 pubmed publisher
    ..Finally, an overview of recent plant membrane proteome studies is provided with the used separation technique and the number of identified membrane proteins listed. ..
  16. Jacquet A, Daminet V, Haumont M, Garcia L, Chaudoir S, Bollen A, et al. Expression of a recombinant Toxoplasma gondii ROP2 fragment as a fusion protein in bacteria circumvents insolubility and proteolytic degradation. Protein Expr Purif. 1999;17:392-400 pubmed
    ..Such fusions could represent an alternative to study the immunogenicity of T. gondii proteins which are difficult to produce because of insolubility and degradation...
  17. Piette A, Fraipont C, Den Blaauwen T, Aarsman M, Pastoret S, Nguyen Distèche M. Structural determinants required to target penicillin-binding protein 3 to the septum of Escherichia coli. J Bacteriol. 2004;186:6110-7 pubmed
    ..We postulate that FtsQ could play a role in regulating the assembly of these division proteins at the division site and the activity of the peptidoglycan assembly machineries within the divisome. ..
  18. Van den Plas D, Merregaert J. In vitro studies on Itm2a reveal its involvement in early stages of the chondrogenic differentiation pathway. Biol Cell. 2004;96:463-70 pubmed
    ..These results demonstrate that overexpression of Itm2a in mouse ATDC5 cells impede the transition to hypertrophic cells. Taken together, our observation supports the involvement of Itm2a in the early stages of chondrogenesis in vitro. ..
  19. Vrijens K, Thys S, De Jeu M, Postnov A, Pfister M, Cox L, et al. Ozzy, a Jag1 vestibular mouse mutant, displays characteristics of Alagille syndrome. Neurobiol Dis. 2006;24:28-40 pubmed
    ..Thirty-seven percent of Ozzy mice showed heart defects. No eye or vertebral abnormalities could be detected. In conclusion, Ozzy mice show two of the major and one minor characteristic of AGS...
  20. De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 1998;391:387-90 pubmed
    ..Our results indicate that mutations in PS1 that manifest clinically cause a gain of function and that inhibition of PS1 activity is a potential target for anti-amyloidogenic therapy in Alzheimer's disease. ..
  21. Baert B, Baysse C, Matthijs S, Cornelis P. Multiple phenotypic alterations caused by a c-type cytochrome maturation ccmC gene mutation in Pseudomonas aeruginosa. Microbiology. 2008;154:127-38 pubmed publisher
    ..In conclusion, we have demonstrated that CcmC is a key determinant for cytochrome c biogenesis, pyoverdine maturation, and expression of some quorum sensing-regulated traits...
  22. De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm J, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999;398:518-22 pubmed
    ..Thus the targeting of gamma-secretase for the treatment of Alzheimer's disease may risk toxicity caused by reduced Notch signalling. ..
  23. Ghys K, Fransen M, Mannaerts G, Van Veldhoven P. Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins. Biochem J. 2002;365:41-50 pubmed
    ..The GFP fusion proteins, tagged at either the N- or C-terminus, were able to restore PTS2 import in rhizomelic chondrodysplasia punctata fibroblasts, and Pex7p-GFP was located both in the lumen of peroxisomes and in the cytosol...
  24. Goossens D, Moens L, Nelis E, Lenaerts A, Glassee W, Kalbe A, et al. Simultaneous mutation and copy number variation (CNV) detection by multiplex PCR-based GS-FLX sequencing. Hum Mutat. 2009;30:472-6 pubmed publisher
  25. Vertommen A, Møller A, Cordewener J, Swennen R, Panis B, Finnie C, et al. A workflow for peptide-based proteomics in a poorly sequenced plant: a case study on the plasma membrane proteome of banana. J Proteomics. 2011;74:1218-29 pubmed publisher
    ..By applying this workflow, integral plasma membrane proteins from banana leaves were successfully identified. ..
  26. Roebroek A, Contreras B, Pauli I, Van de Ven W. cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons. Genomics. 1998;51:98-106 pubmed
    ..Analysis of the expression of the RTN2 gene shows differential expression in human tissues with a strikingly high expression of the 1.3-kb transcript in skeletal muscle. ..
  27. Govaerts C, Lefort A, Costagliola S, Wodak S, Ballesteros J, Van Sande J, et al. A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor. J Biol Chem. 2001;276:22991-9 pubmed
    ..In the TSHr, the conformation of this Asn residue of TM7 would be constrained, in the inactive state, by its Asp partner in TM6. ..
  28. Menten B, Buysse K, Zahir F, Hellemans J, Hamilton S, Costa T, et al. Osteopoikilosis, short stature and mental retardation as key features of a new microdeletion syndrome on 12q14. J Med Genet. 2007;44:264-8 pubmed
    ..The observation of osteopoikilosis lesions should facilitate recognition of this new microdeletion syndrome among children with failure to thrive, short stature and learning disabilities...
  29. De Walle J, Sergent T, Piront N, Toussaint O, Schneider Y, Larondelle Y. Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis. Toxicol Appl Pharmacol. 2010;245:291-8 pubmed publisher
  30. De Smedt M, Leclercq G, Vandekerckhove B, Kerre T, Taghon T, Plum J. T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells. Haematologica. 2011;96:646-54 pubmed publisher
    ..Our data shows that cord blood hematopoietic stem cells have higher T-lymphoid differentiation potential than bone marrow hematopoietic stem cells and that this property is cell autonomous. ..
  31. Octave J, Essalmani R, Tasiaux B, Menager J, Czech C, Mercken L. The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease. J Biol Chem. 2000;275:1525-8 pubmed
    ..Taken together, these results conclusively show that, although PS1 does not cleave APP in Sf9 cells, PS1 allows the secretion of Abeta without endocytosis of APP by CHO cells. ..
  32. Lammertyn E, Van Mellaert L, Meyen E, Lebeau I, De Buck E, Anne J, et al. Molecular and functional characterization of type I signal peptidase from Legionella pneumophila. Microbiology. 2004;150:1475-83 pubmed
    ..Finally it was shown by in vivo experiments that L. pneumophila LepB is a target for (5S,6S)-6-[(R)-acetoxyethyl]-penem-3-carboxylate, a specific inhibitor of type I SPases. ..
  33. Navet R, Douette P, Puttine Marique F, Sluse Goffart C, Jarmuszkiewicz W, Sluse F. Regulation of uncoupling protein activity in phosphorylating potato tuber mitochondria. FEBS Lett. 2005;579:4437-42 pubmed
    ..We propose that in phosphorylating potato tuber mitochondria, the redox state of ubiquinone, which can antagonistically be varied with AA and nBM, modulates inhibition of the PA-activated UCP-sustained H+ leak by GTP. ..
  34. Boyen F, Pasmans F, Donne E, Van Immerseel F, Adriaensen C, Hernalsteens J, et al. Role of SPI-1 in the interactions of Salmonella Typhimurium with porcine macrophages. Vet Microbiol. 2006;113:35-44 pubmed
    ..SPI-1 dependent invasion, however, is not a prerequisite to induce a pro-inflammatory response. ..
  35. Bettendorff L, Hennuy B, Wins P, Schoffeniels E. Thiamin and derivatives as modulators of rat brain chloride channels. Neuroscience. 1993;52:1009-17 pubmed
    ..1 mM veratridine (which should both result in membrane depolarization) increased 36Cl- uptake by 50 and 30% respectively; the inhibitory effect of oxythiamin was enhanced to the same proportion.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  36. Ledent P, Duez C, Vanhove M, Lejeune A, Fonz E, Charlier P, et al. Unexpected influence of a C-terminal-fused His-tag on the processing of an enzyme and on the kinetic and folding parameters. FEBS Lett. 1997;413:194-6 pubmed
    ..This resulted in the secretion of a protein with a different N-terminus, showing that this type of protein engineering might not always be as 'neutral' as generally assumed...
  37. Victoir K, Arevalo J, De Doncker S, Barker D, Laurent T, Godfroid E, et al. Complexity of the major surface protease (msp) gene organization in Leishmania (Viannia) braziliensis: evolutionary and functional implications. Parasitology. 2005;131:207-14 pubmed
    ..We speculate that this would be an adaptive strategy of the parasite. ..
  38. Decottignies A, Evain A, Ghislain M. Binding of Cdc48p to a ubiquitin-related UBX domain from novel yeast proteins involved in intracellular proteolysis and sporulation. Yeast. 2004;21:127-39 pubmed
    ..Together, these results indicate that the Cuil-3 proteins form complexes that are components of the ubiquitin-proteasome system. ..
  39. Dumont B, Castronovo V, Peulen O, Blétard N, Clezardin P, Delvenne P, et al. Differential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis. J Proteome Res. 2012;11:2247-60 pubmed publisher
  40. Wawrzyniak A, Vermeiren E, Zimmermann P, Ivarsson Y. Extensions of PSD-95/discs large/ZO-1 (PDZ) domains influence lipid binding and membrane targeting of syntenin-1. FEBS Lett. 2012;586:1445-51 pubmed publisher
    ..Our study adds new components to the multi-dentate membrane targeting mechanism and highlights the role of N- and C-terminal PDZ extensions in the regulation of syntenin-1 plasma membrane localization. ..
  41. Goffin C, Fraipont C, Ayala J, Terrak M, Nguyen Distèche M, Ghuysen J. The non-penicillin-binding module of the tripartite penicillin-binding protein 3 of Escherichia coli is required for folding and/or stability of the penicillin-binding module and the membrane-anchoring module confers cell septation activity on the fo. J Bacteriol. 1996;178:5402-9 pubmed
    ..The in vivo activity of PBP3 also depends on the M-1-to-E-56 amino-terminal module which encompasses the cytosol, the membrane, and the periplasm and which functions as a noncleaved pseudo-signal peptide. ..
  42. Stiernet P, Nenquin M, Moulin P, Jonas J, Henquin J. Glucose-induced cytosolic pH changes in beta-cells and insulin secretion are not causally related: studies in islets lacking the Na+/H+ exchangeR NHE1. J Biol Chem. 2007;282:24538-46 pubmed
    ..The changes in pH(c) produced by glucose involve HCO(-)(3)-dependent mechanisms. Variations in beta-cell pH(c) are not causally related to changes in insulin secretion. ..
  43. Deleersnijder W, Hong G, Cortvrindt R, Poirier C, Tylzanowski P, Pittois K, et al. Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins. J Biol Chem. 1996;271:19475-82 pubmed
    ..Homology searches of DNA databanks showed that E25 belongs to a novel multigene family, containing three members both in man and mouse. The mouse E25 gene locus (Itm2) was mapped to the X chromosome. ..
  44. Belles Boix E, Babiychuk E, Montagu M, Inze D, Kushnir S. CEF, a sec24 homologue of Arabidopsis thaliana, enhances the survival of yeast under oxidative stress conditions. J Exp Bot. 2000;51:1761-2 pubmed
    ..CEF is homologous to animal and yeast Sec24 proteins. These data suggest that CEF plays a protective role through protein transport during growth under pro-oxidant conditions. ..
  45. Van Kolen K, Gilany K, Moens L, Esmans E, Slegers H. P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1. Cell Signal. 2006;18:1169-81 pubmed
  46. Fransen M, Vastiau I, Brees C, Brys V, Mannaerts G, Van Veldhoven P. Potential role for Pex19p in assembly of PTS-receptor docking complexes. J Biol Chem. 2004;279:12615-24 pubmed
    ..Importantly, we also found that amino acid substitutions resulting in a strongly reduced binding affinity for Pex13p affect the peroxisomal localization of Pex14p. ..
  47. Geukens N, Frederix F, Reekmans G, Lammertyn E, Van Mellaert L, Dehaen W, et al. Analysis of type I signal peptidase affinity and specificity for preprotein substrates. Biochem Biophys Res Commun. 2004;314:459-67 pubmed
    ..In fact, this is the first report of a membrane protein that was covalently attached to a biosensor surface and that retained binding capacity. ..
  48. Grootjans J, Reekmans G, Ceulemans H, David G. Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin. J Biol Chem. 2000;275:19933-41 pubmed
    ..In general, an intramolecular combination of PDZ domains that are weak, taken individually, would appear to be designed to detect rather than drive the formation of specific molecular assemblies. ..
  49. Jacquet A, Coulon L, De Neve J, Daminet V, Haumont M, Garcia L, et al. The surface antigen SAG3 mediates the attachment of Toxoplasma gondii to cell-surface proteoglycans. Mol Biochem Parasitol. 2001;116:35-44 pubmed
    ..Taken together, these results indicate that SAG3 is a first glycoaminoglycan-binding protein associated with Toxoplasma, and SAG3-HSPGs interactions are involved in the parasite attachment to target cells. ..
  50. Nilius B, Prenen J, Hoenderop J, Vennekens R, Hoefs S, Weidema A, et al. Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3. J Biol Chem. 2002;277:30852-8 pubmed
    ..In conclusion, the TM2-TM3 loop is a critical determinant of the inactivation in ECaC1 and ECaC2. ..
  51. Baeyens N, Latrache I, Yerna X, Noppe G, Horman S, Morel N. Redundant control of migration and adhesion by ERM proteins in vascular smooth muscle cells. Biochem Biophys Res Commun. 2013;441:579-85 pubmed publisher
    ..These results indicate that ERM proteins exert a redundant control on PDGF-induced VSMC migration by regulating focal adhesion turn-over and cell adhesion to substrate. ..
  52. Vervoort M, Merritt D, Ghysen A, Dambly Chaudiere C. Genetic basis of the formation and identity of type I and type II neurons in Drosophila embryos. Development. 1997;124:2819-28 pubmed
  53. Herman C, Thevenet D, Bouloc P, Walker G, D Ari R. Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH). Genes Dev. 1998;12:1348-55 pubmed
    ..These results establish a tail-specific pathway for removing abnormal cytoplasmic proteins via the HflB and Clp proteases. ..
  54. Flamez D, Berger V, Kruhøffer M, Orntoft T, Pipeleers D, Schuit F. Critical role for cataplerosis via citrate in glucose-regulated insulin release. Diabetes. 2002;51:2018-24 pubmed
  55. Hendrickx N, Volanti C, Moens U, Seternes O, de Witte P, Vandenheede J, et al. Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. J Biol Chem. 2003;278:52231-9 pubmed
  56. Nijsten T, Geluyckens E, Colpaert C, Lambert J. Peroxisome proliferator-activated receptors in squamous cell carcinoma and its precursors. J Cutan Pathol. 2005;32:340-7 pubmed
    ..Although further research is warranted, these results suggest that PPAR ligands such as fibrates and thiazolidinediones may have chemoprophylactic properties in skin carcinogenesis. ..
  57. Nilius B, Prenen J, Janssens A, Owsianik G, Wang C, Zhu M, et al. The selectivity filter of the cation channel TRPM4. J Biol Chem. 2005;280:22899-906 pubmed
    ..Our findings delineate the selectivity filter of TRPM channels and provide the first insight into the molecular basis of monovalent cation selectivity. ..
  58. Wawrzak D, Metioui M, Willems E, Hendrickx M, De Genst E, Leyns L. Wnt3a binds to several sFRPs in the nanomolar range. Biochem Biophys Res Commun. 2007;357:1119-23 pubmed
    ..These results provide the first measurement of binding affinity of sFRPs for a Wnt, which together with the measurement of antagonistic activity of sFRPs could help understand how sFRPs regulate Wnt signaling. ..
  59. Li T, Froeyen M, Herdewijn P. Computational alanine scanning and free energy decomposition for E. coli type I signal peptidase with lipopeptide inhibitor complex. J Mol Graph Model. 2008;26:813-23 pubmed
    ..coli SPase are also analyzed. This study can be a guide for the optimization of lipopeptide inhibitors and future design of new therapeutic agents for the treatment of bacterial infections. ..
  60. Derouaux A, Wolf B, Fraipont C, Breukink E, Nguyen Distèche M, Terrak M. The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN. J Bacteriol. 2008;190:1831-4 pubmed publisher
  61. Henno A, Blacher S, Lambert C, Deroanne C, Noel A, Lapiere C, et al. Histological and transcriptional study of angiogenesis and lymphangiogenesis in uninvolved skin, acute pinpoint lesions and established psoriasis plaques: an approach of vascular development chronology in psoriasis. J Dermatol Sci. 2010;57:162-9 pubmed publisher
    ..Expansion of BV in PP could be followed by vessel enlargement during progression to PSO, in parallel with a decreased VEGF-A 189/VEGF-A 121 balance in plaques. ..
  62. Boudin E, Piters E, Fransen E, Nielsen T, Andersen M, Roef G, et al. Association study of common variants in the sFRP1 gene region and parameters of bone strength and body composition in two independent healthy Caucasian male cohorts. Mol Genet Metab. 2012;105:508-15 pubmed publisher
    ..However we were not able to replicate those results in the Belgian population. At last we found in the OAS population age specific effects for rs10106678 with whole body BMD and waist to hip ratio. ..
  63. Van Heirstraeten L, Coenen S, Lammens C, Hens N, Goossens H, Malhotra Kumar S. Antimicrobial drug use and macrolide-resistant Streptococcus pyogenes, Belgium. Emerg Infect Dis. 2012;18:1515-8 pubmed publisher
    ..Maintaining drug use below a critical threshold corresponded with low-level macrolide-resistant S. pyogenes and an increased number of erm(A)-harboring emm77 S. pyogenes with low fitness costs...
  64. Van de Walle I, Waegemans E, De Medts J, De Smet G, De Smedt M, Snauwaert S, et al. Specific Notch receptor-ligand interactions control human TCR-??/?? development by inducing differential Notch signal strength. J Exp Med. 2013;210:683-97 pubmed publisher
    ..Our findings reveal that differential Notch receptor-ligand interactions mediate human TCR-?? and -?? T cell differentiation and provide a mechanistic insight into the high Notch dependency of human ?? T cell development. ..
  65. Potelle S, Dulary E, Climer L, Duvet S, Morelle W, Vicogne D, et al. Manganese-induced turnover of TMEM165. Biochem J. 2017;474:1481-1493 pubmed publisher
  66. Dedobbeleer O, Stockis J, van der Woning B, Coulie P, Lucas S. Cutting Edge: Active TGF-?1 Released from GARP/TGF-?1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA. J Immunol. 2017;199:391-396 pubmed publisher
    ..We show in this study that stimulated, human B lymphocytes produce active TGF-?1 from surface GARP/latent TGF-?1 complexes with isotype switching to IgA production. ..
  67. Najem A, Krayem M, Sales F, Hussein N, Badran B, Robert C, et al. P53 and MITF/Bcl-2 identified as key pathways in the acquired resistance of NRAS-mutant melanoma to MEK inhibition. Eur J Cancer. 2017;83:154-165 pubmed publisher
  68. Van Huffel C, Dubois E, Messenguy F. Cloning and sequencing of Schizosaccharomyces pombe car1 gene encoding arginase. Expression of the arginine anabolic and catabolic genes in response to arginine and related metabolites. Yeast. 1994;10:923-33 pubmed
    ..cerevisiae, and also indicates that in S. pombe enzyme compartmentation is not always sufficient to control the arginine metabolic flux. ..
  69. Deconinck N, Rafael J, Beckers Bleukx G, Kahn D, Deconinck A, Davies K, et al. Consequences of the combined deficiency in dystrophin and utrophin on the mechanical properties and myosin composition of some limb and respiratory muscles of the mouse. Neuromuscul Disord. 1998;8:362-70 pubmed
    ..Moreover these results bring some support to the idea that the expression of utrophin in mdx muscle compensates, to some extent, for the lack of dystrophin. ..
  70. Al Mariri A, Tibor A, Mertens P, De Bolle X, Michel P, Godefroid J, et al. Protection of BALB/c mice against Brucella abortus 544 challenge by vaccination with bacterioferritin or P39 recombinant proteins with CpG oligodeoxynucleotides as adjuvant. Infect Immun. 2001;69:4816-22 pubmed
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