Experts and Doctors on melanosomes in United Kingdom
Locale: United Kingdom
Richardson J, Lundegaard P, Reynolds N, Dorin J, Porteous D, Jackson I, et al
. mc1r Pathway regulation of zebrafish melanosome dispersion. Zebrafish. 2008;5:289-95 pubmed publisher
van Steensel M. Making the invisible visible. Semin Cell Dev Biol. 2016;52:58-65 pubmed publisher
..Here, I will illustrate this concept by discussing how human genetic disorders of skin pigmentation reflect the mechanisms underlying this complex and vital process. ..
Strom M, Hume A, Tarafder A, Barkagianni E, Seabra M. A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. J Biol Chem. 2002;277:25423-30 pubmed
..Thus, melanophilin can associate simultaneously with activated Rab27a and myosin Va via distinct regions, and serve as a linker between these proteins. ..
Futter C, Ramalho J, Jaissle G, Seeliger M, Seabra M. The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells. Mol Biol Cell. 2004;15:2264-75 pubmed
..Rab27a and myosin VIIa are likely to be required for association with and movement through the apical actin cytoskeleton, which is a prerequisite for entry into the apical processes. ..
Theos A, Tenza D, Martina J, Hurbain I, Peden A, Sviderskaya E, et al
. Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes. Mol Biol Cell. 2005;16:5356-72 pubmed
Hume A, Tarafder A, Ramalho J, Sviderskaya E, Seabra M. A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes. Mol Biol Cell. 2006;17:4720-35 pubmed
..Our results highlight the importance of the coiled-coil region together with R27BD and EFBD regions of Mlph in the formation of the active melanosomal Rab27a-Mlph-MyoVa complex. ..
Lopes V, Wasmeier C, Seabra M, Futter C. Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis. Mol Biol Cell. 2007;18:3914-27 pubmed
..Together with the high levels of cathepsin D in immature melanosomes of the RPE, our results suggest that melanin deposition may protect the maturing melanosome from the activity of lumenal acid hydrolases...
Figueiredo A, Wasmeier C, Tarafder A, Ramalho J, Baron R, Seabra M. Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. J Biol Chem. 2008;283:23209-16 pubmed publisher
..Our results indicate promiscuity in Rab GEF action and suggest that members of related but functionally distinct Rab subfamilies can be controlled by common activators. ..