Experts and Doctors on melanophores in United States


Locale: United States
Topic: melanophores

Top Publications

  1. Lomakin A, Kraikivski P, Semenova I, Ikeda K, Zaliapin I, Tirnauer J, et al. Stimulation of the CLIP-170--dependent capture of membrane organelles by microtubules through fine tuning of microtubule assembly dynamics. Mol Biol Cell. 2011;22:4029-37 pubmed publisher
  2. Quigley I, Turner J, Nuckels R, Manuel J, Budi E, MacDonald E, et al. Pigment pattern evolution by differential deployment of neural crest and post-embryonic melanophore lineages in Danio fishes. Development. 2004;131:6053-69 pubmed
  3. Slepchenko B, Semenova I, Zaliapin I, Rodionov V. Switching of membrane organelles between cytoskeletal transport systems is determined by regulation of the microtubule-based transport. J Cell Biol. 2007;179:635-41 pubmed
    ..This result suggests that MT transport is the defining factor whose regulation determines the choice of the cytoskeletal tracks during the transport of membrane organelles. ..
  4. Malikov V, Cytrynbaum E, Kashina A, Mogilner A, Rodionov V. Centering of a radial microtubule array by translocation along microtubules spontaneously nucleated in the cytoplasm. Nat Cell Biol. 2005;7:1213-8 pubmed
    ..We hypothesize that similar mechanisms, in the presence of the centrosome, contribute to this centering mechanism and ensure the robustness of cytoplasmic organization. ..
  5. Ren J, McCarthy W, Zhang H, Adolph A, Li L. Behavioral visual responses of wild-type and hypopigmented zebrafish. Vision Res. 2002;42:293-9 pubmed
    ..Together, the data suggest that screening pigments in the retina play a role in the regulation of behavioral visual responses and are necessary for avoiding "scatter" under bright light conditions. ..
  6. Quigley I, Manuel J, Roberts R, Nuckels R, Herrington E, MacDonald E, et al. Evolutionary diversification of pigment pattern in Danio fishes: differential fms dependence and stripe loss in D. albolineatus. Development. 2005;132:89-104 pubmed
    ..Together, these data suggest evolutionary changes in the fms pathway or fms requirements, and identify changes in cellular interactions as a likely mechanism of evolutionary change in Danio pigment patterns...
  7. Lang M, Patterson L, Gordon T, Johnson S, Parichy D. Basonuclin-2 requirements for zebrafish adult pigment pattern development and female fertility. PLoS Genet. 2009;5:e1000744 pubmed publisher
    ..These findings identify bnc2 as an important mediator of adult pigment pattern formation and identify bonaparte mutants as an animal model for dissecting bnc2 functions...
  8. Cooper C, Linbo T, Raible D. Kit and foxd3 genetically interact to regulate melanophore survival in zebrafish. Dev Dyn. 2009;238:875-86 pubmed publisher
    ..Ectopic expression of foxd3 indicates that foxd3 promotes early melanophore death only when kit is inactive. Taken together, these data suggest a kit-dependent role for foxd3 in the regulation of melanophore survival...
  9. Ikeda K, Semenova I, Zhapparova O, Rodionov V. Melanophores for microtubule dynamics and motility assays. Methods Cell Biol. 2010;97:401-14 pubmed publisher
    ..We focus on the preparation of cell cultures, microsurgery and microinjection, fluorescence labeling, and live imaging of MTs...

More Information


  1. Arduini B, Gallagher G, Henion P. Zebrafish endzone regulates neural crest-derived chromatophore differentiation and morphology. PLoS ONE. 2008;3:e2845 pubmed publisher
  2. Kashina A, Semenova I, Ivanov P, Potekhina E, Zaliapin I, Rodionov V. Protein kinase A, which regulates intracellular transport, forms complexes with molecular motors on organelles. Curr Biol. 2004;14:1877-81 pubmed
    ..We propose to call such complexes 'regulated motor units' (RMU)...
  3. Vorobjev I, Malikov V, Rodionov V. Self-organization of a radial microtubule array by dynein-dependent nucleation of microtubules. Proc Natl Acad Sci U S A. 2001;98:10160-5 pubmed
    ..The radial pattern is generated by continuous disassembly and reassembly of MTs and concurrent minus-end-directed transport of pigment granules bearing the nucleation sites...
  4. Semenova I, Gupta D, Usui T, Hayakawa I, Cowan A, Rodionov V. Stimulation of microtubule-based transport by nucleation of microtubules on pigment granules. Mol Biol Cell. 2017;28:1418-1425 pubmed publisher
    ..We conclude that generation of new MT transport tracks by concentration of the leading pigment granules provides a positive feedback loop that enhances delivery of trailing granules to the cell center. ..
  5. Budi E, Patterson L, Parichy D. Post-embryonic nerve-associated precursors to adult pigment cells: genetic requirements and dynamics of morphogenesis and differentiation. PLoS Genet. 2011;7:e1002044 pubmed publisher
    ..These findings provide a foundation for future studies of post-embryonic pigment cell precursors in development, evolution, and neoplasia...
  6. Ikeda K, Zhapparova O, Brodsky I, Semenova I, Tirnauer J, Zaliapin I, et al. CK1 activates minus-end-directed transport of membrane organelles along microtubules. Mol Biol Cell. 2011;22:1321-9 pubmed publisher
  7. An M, Henion P. The zebrafish sf3b1b460 mutant reveals differential requirements for the sf3b1 pre-mRNA processing gene during neural crest development. Int J Dev Biol. 2012;56:223-37 pubmed publisher
    ..Further, the developmental defects caused by the sf3b1(b460) mutation provide insights into genetic interactions among members of the gene regulatory network controlling neural crest development...
  8. Clancey L, Beirl A, Linbo T, Cooper C. Maintenance of melanophore morphology and survival is cathepsin and vps11 dependent in zebrafish. PLoS ONE. 2013;8:e65096 pubmed publisher
    ..Taken together, these data suggest that vps11 promotes normal melanophore morphology and survival by inhibiting cathepsin release and/or activity. ..
  9. Arduini B, Henion P. Melanophore sublineage-specific requirement for zebrafish touchtone during neural crest development. Mech Dev. 2004;121:1353-64 pubmed
    ..Further, our results suggest that, like other neural crest-derived sublineages, melanogenic precursors constitute a heterogeneous population with respect to genetic requirements for development...
  10. Parichy D, Turner J. Zebrafish puma mutant decouples pigment pattern and somatic metamorphosis. Dev Biol. 2003;256:242-57 pubmed
    ..Taken together, these results provide new insights into zebrafish pigment pattern metamorphosis and the capacity for pattern regulation when normal patterning mechanisms go awry...
  11. Lomakin A, Semenova I, Zaliapin I, Kraikivski P, Nadezhdina E, Slepchenko B, et al. CLIP-170-dependent capture of membrane organelles by microtubules initiates minus-end directed transport. Dev Cell. 2009;17:323-33 pubmed publisher
    ..We conclude that MT dynamics are required for the initiation of MT transport of membrane organelles in interphase cells, and that +TIPs such as CLIP-170 play an important role in this process...
  12. Semenova I, Ikeda K, Ivanov P, Rodionov V. The protein kinase A-anchoring protein moesin is bound to pigment granules in melanophores. Traffic. 2009;10:153-60 pubmed publisher
    ..We conclude that Xenopus moesin is an AKAP whose PKA-scaffolding activity plays a role in the regulation of pigment dispersion in Xenopus melanophores...
  13. Semenova I, Burakov A, Berardone N, Zaliapin I, Slepchenko B, Svitkina T, et al. Actin dynamics is essential for myosin-based transport of membrane organelles. Curr Biol. 2008;18:1581-6 pubmed publisher
  14. Ignatius M, Moose H, El Hodiri H, Henion P. colgate/hdac1 Repression of foxd3 expression is required to permit mitfa-dependent melanogenesis. Dev Biol. 2008;313:568-83 pubmed
  15. Rodionov V, Yi J, Kashina A, Oladipo A, Gross S. Switching between microtubule- and actin-based transport systems in melanophores is controlled by cAMP levels. Curr Biol. 2003;13:1837-47 pubmed
    ..Such coordination could occur through regulation of the densities of the two cytoskeletal systems or through regulation of the activities of the cytoskeletal motors by signaling mechanisms...
  16. Eom D, Inoue S, Patterson L, Gordon T, Slingwine R, Kondo S, et al. Melanophore migration and survival during zebrafish adult pigment stripe development require the immunoglobulin superfamily adhesion molecule Igsf11. PLoS Genet. 2012;8:e1002899 pubmed publisher
    ..Our results provide new insights into adult pigment pattern morphogenesis and how cellular interactions mediate pattern formation...
  17. McClintock T, Landers T, Gimelbrant A, Fuller L, Jackson B, Jayawickreme C, et al. Functional expression of olfactory-adrenergic receptor chimeras and intracellular retention of heterologously expressed olfactory receptors. Brain Res Mol Brain Res. 1997;48:270-8 pubmed
    ..We hypothesize that the olfactory receptors have requirements for maturation and targeting to the plasma membrane that are different from most other G-protein-coupled receptors. ..