Experts and Doctors on melanocytes in United Kingdom


Locale: United Kingdom
Topic: melanocytes

Top Publications

  1. MacKenzie M, Jordan S, Budd P, Jackson I. Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo. Dev Biol. 1997;192:99-107 pubmed
    ..Our data do not describe a dependence upon Kit for melanoblast migration or differentiation. ..
  2. Goding C. Melanocytes: the new Black. Int J Biochem Cell Biol. 2007;39:275-9 pubmed
  3. Thody A. alpha-MSH and the regulation of melanocyte function. Ann N Y Acad Sci. 1999;885:217-29 pubmed
    ..The precise nature of this role is unclear, but it could be part of a generic role that alpha-MSH and other POMC peptides have in skin homeostasis. ..
  4. Richardson J, Lundegaard P, Reynolds N, Dorin J, Porteous D, Jackson I, et al. mc1r Pathway regulation of zebrafish melanosome dispersion. Zebrafish. 2008;5:289-95 pubmed publisher
  5. Jackson I, Bennett D. Identification of the albino mutation of mouse tyrosinase by analysis of an in vitro revertant. Proc Natl Acad Sci U S A. 1990;87:7010-4 pubmed
    ..The Dde I site also allowed us to show that all inbred albino mice carry the same mutation and so must be derived from the same progenitor. ..
  6. Carreira S, Dexter T, Yavuzer U, Easty D, Goding C. Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter. Mol Cell Biol. 1998;18:5099-108 pubmed
  7. Aksan I, Goding C. Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo. Mol Cell Biol. 1998;18:6930-8 pubmed
  8. Carreira S, Liu B, Goding C. The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes. J Biol Chem. 2000;275:21920-7 pubmed
  9. Jordan S, Jackson I. MGF (KIT ligand) is a chemokinetic factor for melanoblast migration into hair follicles. Dev Biol. 2000;225:424-36 pubmed
    ..The melanoblasts must be guided to their correct location by other chemotactic signals or move at random and locate by ceasing movement when the follicle is engaged. ..

More Information


  1. Goodall J, Martinozzi S, Dexter T, Champeval D, Carreira S, Larue L, et al. Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. Mol Cell Biol. 2004;24:2915-22 pubmed
    ..These results, together with the observation that BRAF signaling also induces Brn-2 expression, reveal that Brn-2 is a focus for the convergence of two key melanoma-associated signaling pathways that are linked to cell proliferation. ..
  2. Goodall J, Wellbrock C, Dexter T, Roberts K, Marais R, Goding C. The Brn-2 transcription factor links activated BRAF to melanoma proliferation. Mol Cell Biol. 2004;24:2923-31 pubmed
    ..The results suggest that the high levels of Brn-2 expression observed in melanomas link BRAF signaling to increased proliferation. ..
  3. Theos A, Tenza D, Martina J, Hurbain I, Peden A, Sviderskaya E, et al. Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes. Mol Biol Cell. 2005;16:5356-72 pubmed
  4. Hume A, Tarafder A, Ramalho J, Sviderskaya E, Seabra M. A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes. Mol Biol Cell. 2006;17:4720-35 pubmed
    ..Our results highlight the importance of the coiled-coil region together with R27BD and EFBD regions of Mlph in the formation of the active melanosomal Rab27a-Mlph-MyoVa complex. ..
  5. Figueiredo A, Wasmeier C, Tarafder A, Ramalho J, Baron R, Seabra M. Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. J Biol Chem. 2008;283:23209-16 pubmed publisher
    ..Our results indicate promiscuity in Rab GEF action and suggest that members of related but functionally distinct Rab subfamilies can be controlled by common activators. ..
  6. Freter R, Osawa M, Nishikawa S. Adult stem cells exhibit global suppression of RNA polymerase II serine-2 phosphorylation. Stem Cells. 2010;28:1571-80 pubmed publisher
    ..Screening heterogeneous tissues, including tumors, for transcriptionally quiescent cells may result in the identification of cells with stem cell-like phenotypes. ..