Experts and Doctors on map kinase kinase kinases in China


Locale: China
Topic: map kinase kinase kinases

Top Publications

  1. Yang X, Wang Y, Zhang J, Li Y, Xu J, Zhu J, et al. Role of PI3K/Akt and MEK/ERK in mediating hypoxia-induced expression of HIF-1alpha and VEGF in laser-induced rat choroidal neovascularization. Invest Ophthalmol Vis Sci. 2009;50:1873-9 pubmed publisher
    ..LY294002 and PD98059 severely inhibited the formation of CNV. The PI3K/Akt pathway was required for hypoxia-induced expression of HIF-1alpha and VEGF, whereas the MEK/ERK pathway was required only for VEGF in laser-induced rat CNV. ..
  2. Mu N, Gu J, Huang T, Zhang C, Shu Z, Li M, et al. A novel NF-κB/YY1/microRNA-10a regulatory circuit in fibroblast-like synoviocytes regulates inflammation in rheumatoid arthritis. Sci Rep. 2016;6:20059 pubmed publisher
    ..Thus, miR-10a acts as a switch to control this regulatory circuit and may serve as a diagnostic and therapeutic target for RA treatment. ..
  3. Kong X, Lv W, Zhang D, Jiang S, Zhang S, Li D. Genome-wide identification and analysis of expression profiles of maize mitogen-activated protein kinase kinase kinase. PLoS ONE. 2013;8:e57714 pubmed publisher
    ..Our genomics analysis of maize MAPKKK genes provides important information for evolutionary and functional characterization of this family in maize. ..
  4. Xu Z, Lai K, Zhou H, Lin S, Ip N. Ephrin-B1 reverse signaling activates JNK through a novel mechanism that is independent of tyrosine phosphorylation. J Biol Chem. 2003;278:24767-75 pubmed
  5. Zhao J, Pei D, Zhang Q, Zhang G. Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus. Cell Signal. 2007;19:831-43 pubmed
    ..Thus, Cdc42 may be a potential therapeutic target in ischemic brain injury. ..
  6. Tang R, Kong F, Fan B, Liu X, You H, Zhang P, et al. HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module. World J Gastroenterol. 2012;18:1485-95 pubmed publisher
    ..1-X transfected group. HBx can induce HepG2 cell apoptosis via a novel active MLK3-MKK7-JNKs signaling module to upregulate FasL protein expression. ..
  7. Liu W, Liu H, Gao D, Ge G, Zhang P, Sun S, et al. ABCG2 protects kidney side population cells from hypoxia/reoxygenation injury through activation of the MEK/ERK pathway. Cell Transplant. 2013;22:1859-68 pubmed publisher
    ..Collectively, these findings provide evidence for a crucial role for the MEK/ERK-ABCG2 pathway in protecting kidney SP cells from ischemic/hypoxic injury. ..
  8. Zhang F, Yu J, Yang T, Xu D, Chi Z, Xia Y, et al. A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development. J Biol Chem. 2016;291:11466-75 pubmed publisher
    ..We suggest that unique JNK protein complexes are involved in the diversified biological and pathological functions during brain development and pathogenesis of diseases. ..
  9. Pei D, Guan Q, Sun Y, Zhang Q, Xu T, Zhang G. Neuroprotective effects of GluR6 antisense oligodeoxynucleotides on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 region. J Neurosci Res. 2005;82:642-9 pubmed
    ..In conclusion, our results demonstrate that kainate receptor subunit GluR6 plays an important role in neuronal death induced by cerebral ischemia followed by reperfusion. ..

More Information


  1. Wang R, Zhang Q, Han D, Xu J, Lu Q, Zhang G. Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. J Neurochem. 2006;99:1543-54 pubmed
    ..Our data indicate that in response to estrogen, ERalpha interacts with PI3K to activate Akt1, which may inhibit the MLK3-MKK4/7-JNK1/2 pathway to protect hippocampal CA1 neurons against global cerebral ischemia in male rats. ..
  2. Zhang Q, Pei D, Guan Q, Sun Y, Liu X, Zhang G. Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia. Biochemistry. 2007;46:4006-16 pubmed
    ..Thus, specific blockade of PSD-95-MLK3 coupling may reduce the extent of ischemia-reperfusion-induced neuronal cell death. ..
  3. Chen Y, Ip S, Ko K, Poon T, Ng E, Lai P, et al. A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein. J Proteome Res. 2011;10:299-304 pubmed publisher
    ..The results indicate that Sch B triggers the Raf/MEK/ERK signaling pathway, presumably by downregulating RKIP, thereby protecting against carbon tetrachloride-induced cytotoxicity. ..
  4. Tao Y, Wang Y, Wang X, Wang C, Bao K, Ji L, et al. Calycosin Suppresses Epithelial Derived Initiative Key Factors and Maintains Epithelial Barrier in Allergic Inflammation via TLR4 Mediated NF-κB Pathway. Cell Physiol Biochem. 2017;44:1106-1119 pubmed publisher
    ..These findings help to understand the beneficial effects of calycosin on AD, and to develop effective preventive or therapeutic strategies to combat this disease and other epithelial barrier deletion-mediated allergic diseases. ..