Genomes and Genes
Experts and Doctors on mammals in Germany
Publications114 found, 100 shown here
- Goemann B, Potapov A, Ante M, Wingender E. Comparative analysis of topological patterns in different mammalian networks. Genome Inform. 2009;23:32-45 pubmed..Interestingly, some of the most important 3-node patterns of both the transcription and the signaling network can be concatenated to subnetworks comprising many genes that play a particular role in the regulation of cell proliferation. ..
- Dumont M, Laurin M, Jacques F, Pellé E, Dabin W, De Buffrénil V. Inner architecture of vertebral centra in terrestrial and aquatic mammals: a two-dimensional comparative study. J Morphol. 2013;274:570-84 pubmed publisher..7% for coastal oscillatory, and 81.3% for pelagic oscillatory. The possible functional meaning of these results and their potential use for paleobiological inference of locomotion in extinct taxa are discussed...
- Geiser F, Klingenspor M, McAllan B. A functional nexus between photoperiod acclimation, torpor expression and somatic fatty acid composition in a heterothermic mammal. PLoS ONE. 2013;8:e63803 pubmed publisher..They suggest that some of the changes in thermal physiology are linked to the composition of tissue and organ fatty acids. ..
- Dietrich D, Seiler F, Essmann F, Dodt G. Identification of the kinesin KifC3 as a new player for positioning of peroxisomes and other organelles in mammalian cells. Biochim Biophys Acta. 2013;1833:3013-3024 pubmed publisher..Knockdown of KifC3 would then lead to increased minus-end directed peroxisomal transport and cause the observed peroxisomal clustering at the microtubule-organizing center. ..
- Borner J, Pick C, Thiede J, Kolawole O, Kingsley M, Schulze J, et al. Phylogeny of haemosporidian blood parasites revealed by a multi-gene approach. Mol Phylogenet Evol. 2016;94:221-31 pubmed publisher..Support for these relationships was high in nearly all trees, revealing a novel phylogeny of Haemosporida, which is robust to the choice of the outgroup and the method of tree inference. ..
- Steib B, Geier M, Boeckh J. The effect of lactic acid on odour-related host preference of yellow fever mosquitoes. Chem Senses. 2001;26:523-8 pubmed..hircus as did to human odours. All these data demonstrate that olfactory-based host preference of the anthropophilic mosquito A. aegypti is to a large extent due to differences in the amount of lactic acid in the odour samples. ..
- Salzburger W, Steinke D, Braasch I, Meyer A. Genome desertification in eutherians: can gene deserts explain the uneven distribution of genes in placental mammalian genomes?. J Mol Evol. 2009;69:207-16 pubmed publisher..We show that the uneven distribution of gene deserts is a derived character state of eutherians. The functional and evolutionary significance of this particular feature of eutherian genomes remains to be explained. ..
- Vater M, Kössl M. Comparative aspects of cochlear functional organization in mammals. Hear Res. 2011;273:89-99 pubmed publisher..Furthermore, structural functional correlations important for tonotopic cochlear organization and predictions of hearing capabilities are discussed. ..
- Bauer E, Williams B, Smidt H, Verstegen M, Mosenthin R. Influence of the gastrointestinal microbiota on development of the immune system in young animals. Curr Issues Intest Microbiol. 2006;7:35-51 pubmed..Regulation of the composition of the GIT microbiota, e.g. by the use of pre- and probiotics, offers the possibility to influence the development of mucosal, and also systemic immunity. ..
- Buchler M, Tisljar U, Wolf D. Proteinase yscD (oligopeptidase yscD). Structure, function and relationship of the yeast enzyme with mammalian thimet oligopeptidase (metalloendopeptidase, EP 24.15). Eur J Biochem. 1994;219:627-39 pubmed..They do not show any grossly altered phenotype but exhibit a decrease in the intracellular degradation of peptides. This suggests a function of proteinase yscD in the late stages of protein degradation. ..
- Langheinrich U, Hennen E, Stott G, Vacun G. Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling. Curr Biol. 2002;12:2023-8 pubmed..We conclude that zebrafish represents a promising model organism for future compound-based and genetic screens and believe that it will help to identify and characterize new anticancer drugs and new targets for cancer treatment. ..
- Barrionuevo F, Scherer G. SOX E genes: SOX9 and SOX8 in mammalian testis development. Int J Biochem Cell Biol. 2010;42:433-6 pubmed publisher..In the combined absence of Sox9 and Sox8, primary male infertility evolves, revealing functional redundancy. Loss of Sox10 has no effect on testis development. ..
- Thierbach R, Drewes G, Fusser M, Voigt A, Kuhlow D, Blume U, et al. The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals. Biochem J. 2010;432:165-72 pubmed publisher..These findings indicate that frataxin modulates DNA-repair mechanisms probably due to its impact on ISC-dependent repair proteins, linking mitochondrial dysfunction to DNA repair and tumour initiation. ..
- Schwanhäusser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J, et al. Global quantification of mammalian gene expression control. Nature. 2011;473:337-42 pubmed publisher..Quantitative information about all stages of gene expression provides a rich resource and helps to provide a greater understanding of the underlying design principles. ..
- Meyer W. Distribution of tissue kallikrein in the integumental blood vessel system of wild mammals. Cell Mol Biol (Noisy-le-grand). 2001;47 Online Pub:OL125-30 pubmed..The results obtained are discussed with special regard to the general skin biology of the wild mammals studied, considering comparative hair coat density and normal hazards to the integument. ..
- Brandt J, Schrauth S, Veith A, Froschauer A, Haneke T, Schultheis C, et al. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. Gene. 2005;345:101-11 pubmed..Although additional analysis will be required to establish the function of the retrotransposon-derived Mart neogenes, these observations support the evolutionary importance of retrotransposable elements as a source of genetic novelty. ..
- Rattenborg N. Response to commentary on evolution of slow-wave sleep and palliopallial connectivity in mammals and birds: a hypothesis. Brain Res Bull. 2007;72:187-93 pubmed
- Grassmann R, Jeang K. The roles of microRNAs in mammalian virus infection. Biochim Biophys Acta. 2008;1779:706-11 pubmed publisher..In this review, we summarize in brief recent findings on the antiviral activities of cellular miRNAs and the viral counter-responses to the cell's RNAi restriction. ..
- Haas A, Brehm K, Kreft J, Goebel W. Cloning, characterization, and expression in Escherichia coli of a gene encoding Listeria seeligeri catalase, a bacterial enzyme highly homologous to mammalian catalases. J Bacteriol. 1991;173:5159-67 pubmed..coli, was detected next to the putative promoter region of the L. seeligeri catalase gene. ..
- Kruse U, Sippel A. The genes for transcription factor nuclear factor I give rise to corresponding splice variants between vertebrate species. J Mol Biol. 1994;238:860-5 pubmed..This finding leads to the prediction that more mammalian isoforms will be discovered corresponding to the chicken NFI variants reported here. ..
- Gerber J, Gogel E, Berger C, Wallisch M, Muller F, Grummt I, et al. Termination of mammalian rDNA replication: polar arrest of replication fork movement by transcription termination factor TTF-I. Cell. 1997;90:559-67 pubmed..Thus, the same factor that blocks elongating RNA polymerase I prevents head-on collision between the DNA replication apparatus and the transcription machinery. ..
- Viertlboeck B, Göbel T. The chicken leukocyte receptor cluster. Vet Immunol Immunopathol. 2011;144:1-10 pubmed publisher..Detailed analyses of CHIR-AB1, its crystal structure, the interaction to IgY and functional capabilities allow us to draw conclusions regarding Fc receptor phylogeny and function. ..
- Janke A, Gemmell N, Feldmaier Fuchs G, von Haeseler A, P bo S. The mitochondrial genome of a monotreme--the platypus (Ornithorhynchus anatinus). J Mol Evol. 1996;42:153-9 pubmed..When the protein-coding sequences are used to reconstruct a phylogeny of mammals, the data suggest that monotremes and marsupials are sister groups and thus that placental mammals represent the most ancient divergence among mammals...
- Keller C, Schulz R. Nucleotide and deduced amino acid sequence of equine retinal and pineal gland phosducin. Am J Vet Res. 2001;62:61-6 pubmed..Equine PHD is a highly conserved protein that has homology of immunologic interest with rat PHD. These results establish a basis for studying the role of PHD in ocular inflammation of horses. ..
- Kuhn M. Structure, regulation, and function of mammalian membrane guanylyl cyclase receptors, with a focus on guanylyl cyclase-A. Circ Res. 2003;93:700-9 pubmed
- Hutter B, Bieg M, Helms V, Paulsen M. Divergence of imprinted genes during mammalian evolution. BMC Evol Biol. 2010;10:116 pubmed publisher..Moreover, intensification of imprinting in modern rodents seems to have shifted the evolutionary fate of imprinted genes towards strong purifying selection. ..
- von Werder A, Seidler B, Schmid R, Schneider G, Saur D. Production of avian retroviruses and tissue-specific somatic retroviral gene transfer in vivo using the RCAS/TVA system. Nat Protoc. 2012;7:1167-83 pubmed publisher..The protocol takes 4 weeks from transfection of chicken fibroblasts, which act as the host cells for viral production, to the transduction of TVA-transgenic mice. ..
- Schwerdtfeger S, Melzig M. Sialidases in biological systems. Pharmazie. 2010;65:551-61 pubmed..In pathogen organisms sialidases give insight in coevolution and interaction between pathogen or commensale and host. As well the enzymes are of interest in drug targeting, like neuraminidase inhibitors of influenza viruses. ..
- Haubrich S, Schwarz H, Bukauskas F, Lichtenberg Frate H, Traub O, Weingart R, et al. Incompatibility of connexin 40 and 43 Hemichannels in gap junctions between mammalian cells is determined by intracellular domains. Mol Biol Cell. 1996;7:1995-2006 pubmed..e., Cx40*43C3, showed neither homotypic nor heterotypic coupling with Cx40 and Cx43 transfectants, suggesting that the C-terminal region of Cx43 determined incompatibility. ..
- Roenneberg T, Merrow M. Circadian systems: different levels of complexity. Philos Trans R Soc Lond B Biol Sci. 2001;356:1687-96 pubmed..This review summarizes some of the complexities found at the level of organisms, cells and molecules, and highlights similar strategies that apparently solve similar problems at the different levels of the circadian system. ..
- Eichenlaub Ritter U, Shen Y, Tinneberg H. Manipulation of the oocyte: possible damage to the spindle apparatus. Reprod Biomed Online. 2002;5:117-24 pubmed
- Schulz H, Goetz T, Kaschkoetoe J, Weber B. The Retinome - defining a reference transcriptome of the adult mammalian retina/retinal pigment epithelium. BMC Genomics. 2004;5:50 pubmed..To make this unique resource freely available we have built a database providing a query interface to the reference retinome 1. ..
- Biegel A, Gebauer S, Hartrodt B, Brandsch M, Neubert K, Thondorf I. Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005;48:4410-9 pubmed..The new 3D-QSAR model was used to design a new druglike compound mimicking a dipeptide. The predicted K(i) value was confirmed experimentally. ..
- Koch Nolte F, Kernstock S, Mueller Dieckmann C, Weiss M, Haag F. Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases. Front Biosci. 2008;13:6716-29 pubmed..Recently, molecular cloning, site directed mutagenesis and three-dimensional structural analyses of prototype mammalian ARTs and ARHs have shed fresh insight into the structure and function of these intriguing enzymes. ..
- Meffin H, Grothe B. Selective filtering to spurious localization cues in the mammalian auditory brainstem. J Acoust Soc Am. 2009;126:2437-54 pubmed publisher..These results provide new insights into how the mammalian auditory system processes information about multiple sound sources. ..
- Kenngott R, Al Banaw A, Vermehren M, Wendl J, Sinowatz F. Application of laser-assisted microdissection for gene expression analysis of mammalian germ cells. Anat Histol Embryol. 2010;39:219-26 pubmed publisher..In this review, we give a short overview of the application of LAM in combination with quantitative qPCR for the analysis of gene expression in mammalian germ cells. ..
- Gross T, Lützelberger M, Weigmann H, Klingenhoff A, Shenoy S, Kaufer N. Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. Nucleic Acids Res. 1997;25:1028-35 pubmed..pombe. Prp4 and the recombinant yeast/mouse protein kinase phosphorylate the human SR splicing factor ASF/SF2 in vitro in its RS domain. ..
- Marx M, Rivera Milla E, Stummeyer K, Gerardy Schahn R, Bastmeyer M. Divergent evolution of the vertebrate polysialyltransferase Stx and Pst genes revealed by fish-to-mammal comparison. Dev Biol. 2007;306:560-71 pubmed..Our findings reveal an important divergence of Stx and Pst enzymes in vertebrates, which is also characterized by a differential gene loss and rapid evolution of Pst genes within the bony-fish class. ..
- Muller J, Scheyer T, Head J, Barrett P, Werneburg I, Ericson P, et al. Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes. Proc Natl Acad Sci U S A. 2010;107:2118-23 pubmed publisher..Our study highlights the importance of fossils in large-scale investigations of evolutionary developmental processes. ..
- Laggerbauer B, Lauber J, Luhrmann R. Identification of an RNA-dependent ATPase activity in mammalian U5 snRNPs. Nucleic Acids Res. 1996;24:868-75 pubmed..Furthermore, both the formation of the crosslink and ATPase activity appear with a similar substrate specificity for ATP. ..
- Kalies K, Hartmann E. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. J Biol Chem. 1996;271:3925-9 pubmed..Therefore, SPC12 and SPC25 are likely to be involved in processes other than the enzymatic cleavage of the signal sequence. ..
- Hiendleder S, Lewalski H, Wassmuth R, Janke A. The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries) and comparison with the other major ovine haplotype. J Mol Evol. 1998;47:441-8 pubmed..indicus and B. taurus cattle. Datings based on complete mtDNAs suggest that the bovine and ovine lineages diverged about 30 million years before present. This dating is considerably earlier than that proposed previously. ..
- Pette D. Historical Perspectives: plasticity of mammalian skeletal muscle. J Appl Physiol (1985). 2001;90:1119-24 pubmed..Fiber-type transitions resulting from multiple qualitative and quantitative changes in gene expression occur sequentially in a regular order within a spectrum of pure and hybrid fiber types...
- Oswald F, Tauber B, Dobner T, Bourteele S, Kostezka U, Adler G, et al. p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol Cell Biol. 2001;21:7761-74 pubmed..Based on physical interaction with Notch-1-IC and coactivator functions of p300, we propose a model for Notch-1-mediated gene regulation via p300. ..
- Haferkamp I, Hackstein J, Voncken F, Schmit G, Tjaden J. Functional integration of mitochondrial and hydrogenosomal ADP/ATP carriers in the Escherichia coli membrane reveals different biochemical characteristics for plants, mammals and anaerobic chytrids. Eur J Biochem. 2002;269:3172-81 pubmed
- Uinuk Ool T, Mayer W, Sato A, Dongak R, Cooper M, Klein J. Lamprey lymphocyte-like cells express homologs of genes involved in immunologically relevant activities of mammalian lymphocytes. Proc Natl Acad Sci U S A. 2002;99:14356-61 pubmed..It reopens the question of the stage jawless fishes reached in the evolution of their immune system. ..
- Kohn M, Kehrer Sawatzki H, Vogel W, Graves J, Hameister H. Wide genome comparisons reveal the origins of the human X chromosome. Trends Genet. 2004;20:598-603 pubmed..This enables surprising new insights into the origins of the mammalian X chromosome. ..
- Fries T, Betz C, Sohn K, Caesar S, Schlenstedt G, Bailer S. A novel conserved nuclear localization signal is recognized by a group of yeast importins. J Biol Chem. 2007;282:19292-301 pubmed
- Jastroch M, Withers K, Taudien S, Frappell P, Helwig M, Fromme T, et al. Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis. Physiol Genomics. 2008;32:161-9 pubmed..Our data suggest that an archetypal brown adipose tissue was present at least 150 million yr ago allowing early mammals to produce endogenous heat in the cold, without dependence on shivering and locomotor activity. ..
- Grzmil P, Boinska D, Kleene K, Adham I, Schlüter G, Kämper M, et al. Prm3, the fourth gene in the mouse protamine gene cluster, encodes a conserved acidic protein that affects sperm motility. Biol Reprod. 2008;78:958-67 pubmed publisher..We have developed a competition test in which a mutant male has to compete with a rival wild-type male to fertilize a female; the implications of these results are also discussed. ..
- Tureci O, Koslowski M, Helftenbein G, Castle J, Rohde C, Dhaene K, et al. Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals. Gene. 2011;481:83-92 pubmed publisher..Given that CLDN18.2 is a novel drug target candidate, our data is also relevant for drug development as it reveals all six investigated mammalian species as suitable models for testing safety of CLDN18.2 targeting regimen. ..
- Rossow T, Heyman J, Ehrlicher A, Langhoff A, Weitz D, Haag R, et al. Controlled synthesis of cell-laden microgels by radical-free gelation in droplet microfluidics. J Am Chem Soc. 2012;134:4983-9 pubmed publisher..We also demonstrate the encapsulation of mammalian cells including fibroblasts and lymphoblasts. ..
- Frohn A, Eberl H, Stöhr J, Glasmacher E, Rüdel S, Heissmeyer V, et al. Dicer-dependent and -independent Argonaute2 protein interaction networks in mammalian cells. Mol Cell Proteomics. 2012;11:1442-56 pubmed publisher..In contrast to our current view, we find that Ago-mRNA interactions can also take place in the absence of miRNAs. Our proteomics approach provides a rich resource for further functional studies on the cellular roles of Ago proteins. ..
- Münster P, Fechner K, Völkel I, von Buchholz A, Czerny C. Distribution of Mycobacterium avium ssp. paratuberculosis in a German zoological garden determined by IS900 semi-nested and quantitative real-time PCR. Vet Microbiol. 2013;163:116-23 pubmed publisher..In order to restrict further spread of MAP in European zoos, additional investigations regarding the existing transmission pathways of MAP in zoos are recommended...
- Schütte L, Baumeister S, Weis B, Hudemann C, Hanschmann E, Lillig C. Identification of potential protein dithiol-disulfide substrates of mammalian Grx2. Biochim Biophys Acta. 2013;1830:4999-5005 pubmed publisher..The 2-D redox blot may be useful for the analysis of the overall thiol-redox state of proteins with high molecular weight and numerous cysteinyl residues, that evaded analysis by previously described methods. ..
- Kaldenhoff R, Kai L, Uehlein N. Aquaporins and membrane diffusion of CO2 in living organisms. Biochim Biophys Acta. 2014;1840:1592-5 pubmed publisher..This article is part of a Special Issue entitled Aquaporins. ..
- Drabent B, Kardalinou E, Bode C, Doenecke D. Association of histone H4 genes with the mammalian testis-specific H1t histone gene. DNA Cell Biol. 1995;14:591-7 pubmed
- Lehle L, Eiden A, Lehnert K, Haselbeck A, Kopetzki E. Glycoprotein biosynthesis in Saccharomyces cerevisiae: ngd29, an N-glycosylation mutant allelic to och1 having a defect in the initiation of outer chain formation. FEBS Lett. 1995;370:41-5 pubmed..The data indicate that this mutant strain is a suitable host for the expression of recombinant glycoproteins from different origin in S. cerevisiae to obtain mammalian oligomannosidic type N-linked carbohydrate chains. ..
- Janke A, Feldmaier Fuchs G, Thomas W, von Haeseler A, P bo S. The marsupial mitochondrial genome and the evolution of placental mammals. Genetics. 1994;137:243-56 pubmed..Furthermore, the data indicate that the lineages leading to the mouse and rat may have diverged from each other as much as 35 million years ago...
- Antz C, Geyer M, Fakler B, Schott M, Guy H, Frank R, et al. NMR structure of inactivation gates from mammalian voltage-dependent potassium channels. Nature. 1997;385:272-5 pubmed..The RCK4 inactivation peptide (RCK4-IP) shows a similar spatial distribution of charged and uncharged regions, but is more flexible and less ordered in its amino-terminal part. ..
- Moepps B, Braun M, Knöpfle K, Dillinger K, Knochel W, Gierschik P. Characterization of a Xenopus laevis CXC chemokine receptor 4: implications for hematopoietic cell development in the vertebrate embryo. Eur J Immunol. 2000;30:2924-34 pubmed..The hematopoietic defects observed in mice lacking SDF-1 or CXCR4 may, at least in part, be explained by a disturbance of this migration. ..
- Töpfer Petersen E, Wagner A, Friedrich J, Petrunkina A, Ekhlasi Hundrieser M, Waberski D, et al. Function of the mammalian oviductal sperm reservoir. J Exp Zool. 2002;292:210-5 pubmed..Spermadhesins, a new class of animal lectins and the major secretory products of the porcine seminal vesicle, associate with the sperm surface at ejaculation and are candidate molecules for the receptors of the epithelial carbohydrates. ..
- Witte H, Biltzinger J, Hackert R, Schilling N, Schmidt M, Reich C, et al. Torque patterns of the limbs of small therian mammals during locomotion on flat ground. J Exp Biol. 2002;205:1339-53 pubmed..The results are compared with the few torque data available for various joints of cats (Felis catus), dogs (Canis lupus f. familiaris), goats (Capra sp.) and horses (Equus przewalskii f. caballus)...
- Mühlenbein N, Hofmann S, Rothbauer U, Bauer M. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. J Biol Chem. 2004;279:13540-6 pubmed..We conclude that different mechanisms and specific requirements for import and insertion of mammalian carrier preproteins have evolved in higher eukaryotes. ..
- Hansel A, Heinemann S, Hoshi T. Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation. Biochim Biophys Acta. 2005;1703:239-47 pubmed..More MSR-dependent physiological phenomena await to be discovered. ..
- Otto H, Conz C, Maier P, Wölfle T, Suzuki C, Jeno P, et al. The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. Proc Natl Acad Sci U S A. 2005;102:10064-9 pubmed..We conclude that despite a low degree of homology on the amino acid level cooperation of ribosome-associated chaperones with the translational apparatus is well conserved in eukaryotic cells. ..
- Behlke J, Koellner G, Bzowska A. Oligomeric structure of mammalian purine nucleoside phosphorylase in solution determined by analytical ultracentrifugation. Z Naturforsch C. 2005;60:927-31 pubmed
- Krull M, Petrusma M, Makalowski W, BROSIUS J, Schmitz J. Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). Genome Res. 2007;17:1139-45 pubmed
- Bergsdorf E, Zdebik A, Jentsch T. Residues important for nitrate/proton coupling in plant and mammalian CLC transporters. J Biol Chem. 2009;284:11184-93 pubmed publisher..Gating and proton glutamates play similar roles in bacterial, plant, and mammalian CLC anion/proton exchangers...
- Solovei I, Kreysing M, Lanctôt C, Kösem S, Peichl L, Cremer T, et al. Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution. Cell. 2009;137:356-68 pubmed publisher..Comparison of the two patterns suggests that the conventional architecture prevails in eukaryotic nuclei because it results in more flexible chromosome arrangements, facilitating positional regulation of nuclear functions. ..
- Sabour D, Scholer H. Reprogramming and the mammalian germline: the Weismann barrier revisited. Curr Opin Cell Biol. 2012;24:716-23 pubmed publisher..In this review, we focus on the capacity of germ cells and somatic cells (soma) to transfer genetic information to the next generation, and thus revisit the Weismann theory of heredity. ..
- Suh A, BROSIUS J, Schmitz J, Kriegs J. The genome of a Mesozoic paleovirus reveals the evolution of hepatitis B viruses. Nat Commun. 2013;4:1791 pubmed publisher..Our study reveals previously undiscovered and multi-faceted insights into prehistoric hepatitis B virus evolution and provides valuable resources for future studies, such as in-vitro resurrection of Mesozoic hepadnaviruses. ..
- Safi K, Armour Marshall K, Baillie J, Isaac N. Global patterns of evolutionary distinct and globally endangered amphibians and mammals. PLoS ONE. 2013;8:e63582 pubmed publisher..In addition, we investigate whether environmental conditions can predict the observed spatial pattern in ED and EDGE globally...
- Spletter M, Schnorrer F. Transcriptional regulation and alternative splicing cooperate in muscle fiber-type specification in flies and mammals. Exp Cell Res. 2014;321:90-8 pubmed publisher..Thus, research in Drosophila can provide important mechanistic insight into muscle fiber specification, which is relevant to homologous processes in mammals and to the pathology of muscle diseases. ..
- Rad M, Phan H, Kirchrath L, Tan P, Kirchhausen T, Hollenberg C, et al. Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions. J Cell Sci. 1995;108 ( Pt 4):1605-15 pubmed..These Golgi-specific effects of apl2 delta in chc1-ts cells provide evidence that Apl2p is a component of an AP complex that interacts with clathrin at the Golgi apparatus. ..
- Roeper J, Pongs O. Presynaptic potassium channels. Curr Opin Neurobiol. 1996;6:338-41 pubmed
- Lesche R, Ruther U. Close linkage of p130 and Ft1 is conserved among mammals. Mamm Genome. 1998;9:253-5 pubmed
- Schmidt A, Gromoll J, Weinbauer G, Galla H, Chappel S, Simoni M. Cloning and expression of cynomolgus monkey (Macaca fascicularis) gonadotropins luteinizing hormone and follicle-stimulating hormone and identification of two polymorphic sites in the luteinizing hormone beta subunit. Mol Cell Endocrinol. 1999;156:73-83 pubmed..This work represents a further step towards production of recombinant monkey LH and FSH which can be used in a homologous experimental setting in the cynomolgus monkey. ..
- Lill R, Kispal G. Mitochondrial ABC transporters. Res Microbiol. 2001;152:331-40 pubmed..The function of the mitochondrial Mdl1/2p-like proteins is not clear at present with the notable exception of murine ABC-me that may transport intermediates of heme biosynthesis from the matrix to the cytosol in erythroid tissues...
- Strohner R, Nemeth A, Jansa P, Hofmann Rohrer U, Santoro R, Langst G, et al. NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines. EMBO J. 2001;20:4892-900 pubmed..The results suggest that NoRC is a novel nucleolar chromatin remodeling machine that may serve a role in the regulation of the rDNA locus. ..
- Warnke S, Kemmler S, Hames R, Tsai H, Hoffmann Rohrer U, Fry A, et al. Polo-like kinase-2 is required for centriole duplication in mammalian cells. Curr Biol. 2004;14:1200-7 pubmed..These results show that Plk2 is a physiological centrosomal protein and that its kinase activity is likely to be required for centriole duplication near the G1-to-S phase transition. ..
- Schmitz J, Churakov G, Zischler H, BROSIUS J. A novel class of mammalian-specific tailless retropseudogenes. Genome Res. 2004;14:1911-5 pubmed..Thus, tailless retropseudogenes point to a novel, variant mechanism for the biogenesis of retrosequences. ..
- Paulsen M, Khare T, Burgard C, Tierling S, Walter J. Evolution of the Beckwith-Wiedemann syndrome region in vertebrates. Genome Res. 2005;15:146-53 pubmed..In line with that, imprinting centers in mammals apparently exhibit a high degree of structural and sequence variation despite conserved epigenetic marking. ..
- Martin T, Luo Z. Paleontology. Homoplasy in the mammalian ear. Science. 2005;307:861-2 pubmed
- Mess A, Carter A. Evolutionary transformations of fetal membrane characters in Eutheria with special reference to Afrotheria. J Exp Zool B Mol Dev Evol. 2006;306:140-63 pubmed..e., the occurrence of a four-lobed allantoic sac. Thus, contrary to previous assertions, it is possible to identify morphological characters that could be synapomorphic for this novel taxon. ..
- Saraiva L, Korsching S. A novel olfactory receptor gene family in teleost fish. Genome Res. 2007;17:1448-57 pubmed