Genomes and Genes
Experts and Doctors on magnesium in Germany
Publications146 found, 100 shown here
- Schwanstecher C, Dickel C, Ebers I, Lins S, Zünkler B, Panten U. Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells. Br J Pharmacol. 1992;107:87-94 pubmed..Strong inhibition of the channel openings by sulphonylureas results from occupation of both sites for nucleotides. Diazoxide is only effective when the site for stimulatory nucleotides is occupied. ..
- Obermann W, Sondermann H, Russo A, Pavletich N, Hartl F. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. J Cell Biol. 1998;143:901-10 pubmed..Our results establish Hsp90 as an ATP-dependent chaperone. ..
- Ohm T, von Dewitz G, Witte K, Nitsch R, Lemmer B. Basal and stimulated hippocampal adenylate cyclase activity in the experimentally lesioned rat entorhinal cortex. Acta Neuropathol. 1999;98:389-95 pubmed..Our data suggests that the loss of entorhinal afferents alone cannot explain the reduction in cyclase-activity seen in 'entorhinal' cases. ..
- Kuhn A, Schroder W, Bauch J. The kinetics of calcium and magnesium entry into mycorrhizal spruce roots. Planta. 2000;210:488-96 pubmed..The kinetics of Ca and Mg entry at + 6 degrees C were similar to those obtained at a root temperature of +22 degrees C...
- Weber S, Hoffmann K, Jeck N, Saar K, Boeswald M, Kuwertz Broeking E, et al. Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene. Eur J Hum Genet. 2000;8:414-22 pubmed..This study confirms the implication of paracellin-1 defects in FHHNC and points to a predominant role of this protein in the paracellular reabsorption of divalent cations in the TAL...
- Rettinger J, Schmalzing G. Activation and desensitization of the recombinant P2X1 receptor at nanomolar ATP concentrations. J Gen Physiol. 2003;121:451-61 pubmed..Our results imply that nanomolar extracellular ATP concentrations can obscure P2X1 receptor responses by driving a significant fraction of the receptor pool into a long-lasting refractory closed state. ..
- Balaban T. Relevance of the diastereotopic ligation of magnesium atoms of chlorophylls in the major light-harvesting complex II (LHC II) of green plants. Photosynth Res. 2005;86:251-62 pubmed..A careful pairing of carotenoids with the special beta-Chls, which could quench their triplet states efficiently, implies a functional relevance of this diastereotopic ligation. ..
- Carius Y, Christian H, Faust A, Zander U, Klink B, Kornberger P, et al. Structural insight into substrate differentiation of the sugar-metabolizing enzyme galactitol dehydrogenase from Rhodobacter sphaeroides D. J Biol Chem. 2010;285:20006-14 pubmed publisher..The presented structures provide valuable information for a rational design of this enzyme to improve its stability against pH, temperature, or solvent concentration and to optimize product yield in bioreactors. ..
- Brauser A, Schroeder I, Gutsmann T, Cosentino C, Moroni A, Hansen U, et al. Modulation of enrofloxacin binding in OmpF by Mg2+ as revealed by the analysis of fast flickering single-porin current. J Gen Physiol. 2012;140:69-82 pubmed publisher..The voltage dependence suggests that the dipole of the antibiotic has to be adequately oriented to facilitate binding. ..
- Wegscheid B, Hartmann R. The precursor tRNA 3'-CCA interaction with Escherichia coli RNase P RNA is essential for catalysis by RNase P in vivo. RNA. 2006;12:2135-48 pubmed..Thus, we cannot exclude that altered folding of the mutant RNAs may have also contributed to their in vivo defect. ..
- Kerkhoff C, Vogl T, Nacken W, Sopalla C, Sorg C. Zinc binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8/A9 protein complex. FEBS Lett. 1999;460:134-8 pubmed..Due to the fact that the inhibitory effect of Zn2+ was present at physiological serum concentrations, it is assumed that released S100A8/A9 may carry AA at inflammatory lesions, but not within the blood compartment. ..
- Hort N, Huang Y, Fechner D, Störmer M, Blawert C, Witte F, et al. Magnesium alloys as implant materials--principles of property design for Mg-RE alloys. Acta Biomater. 2010;6:1714-25 pubmed publisher..Recommendations are given for the design of future degradable magnesium based implant materials...
- Frère F, Reents H, Schubert W, Heinz D, Jahn D. Tracking the evolution of porphobilinogen synthase metal dependence in vitro. J Mol Biol. 2005;345:1059-70 pubmed
- Plchova H, Hartung F, Puchta H. Biochemical characterization of an exonuclease from Arabidopsis thaliana reveals similarities to the DNA exonuclease of the human Werner syndrome protein. J Biol Chem. 2003;278:44128-38 pubmed..Our results indicate that a type of WRN-like exonuclease activity seems to be a common feature of the DNA metabolism of animals and plants. ..
- Böhm I, Halbherr A, Smaglinski S, Ernst A, Boger P. In vitro activation of dinitrogenase reductase from the cyanobacterium Anabaena variabilis (ATCC 29413). J Bacteriol. 1992;174:6179-83 pubmed..The activating principle is localized in the heterocyst and was found effective only when prepared from cells exhibiting active nitrogenase. It also restores the activity of modified Fe-protein from R. rubrum. ..
- Yang L, Huang Y, Feyerabend F, Willumeit R, Kainer K, Hort N. Influence of ageing treatment on microstructure, mechanical and bio-corrosion properties of Mg-Dy alloys. J Mech Behav Biomed Mater. 2012;13:36-44 pubmed publisher..After ageing at 200 °C, the corrosion rate of Mg-20Dy alloy increases largely in 0.9 wt% NaCl solution, but remains unchanged in cell culture medium. ..
- Pingoud V, Conzelmann C, Kinzebach S, Sudina A, Metelev V, Kubareva E, et al. PspGI, a type II restriction endonuclease from the extreme thermophile Pyrococcus sp.: structural and functional studies to investigate an evolutionary relationship with several mesophilic restriction enzymes. J Mol Biol. 2003;329:913-29 pubmed..These results are discussed in an evolutionary context...
- de Rudder K, Sohlenkamp C, Geiger O. Plant-exuded choline is used for rhizobial membrane lipid biosynthesis by phosphatidylcholine synthase. J Biol Chem. 1999;274:20011-6 pubmed..meliloti. We further demonstrate that roots of host plants of S. meliloti exude choline and that the amounts of exuded choline are sufficient to allow for maximal phosphatidylcholine biosynthesis in S. meliloti via the novel pathway. ..
- Benie A, Blume A, Schmidt R, Reutter W, Hinderlich S, Peters T. Characterization of ligand binding to the bifunctional key enzyme in the sialic acid biosynthesis by NMR: II. Investigation of the ManNAc kinase functionality. J Biol Chem. 2004;279:55722-7 pubmed..This provides a cornerstone for the rational design of drugs for novel therapeutic applications by altering the sialic acid decorations of cell walls. ..
- Jinek M, Chen Y, Clausen H, Cohen S, Conti E. Structural insights into the Notch-modifying glycosyltransferase Fringe. Nat Struct Mol Biol. 2006;13:945-6 pubmed..Mutations of several invariant residues in this pocket impair Fringe activity in vivo. ..
- Chubanov V, Schlingmann K, Wäring J, Heinzinger J, Kaske S, Waldegger S, et al. Hypomagnesemia with secondary hypocalcemia due to a missense mutation in the putative pore-forming region of TRPM6. J Biol Chem. 2007;282:7656-67 pubmed..We conclude that a functional defect in the putative pore of TRPM6/7 channel complexes is sufficient to impair body magnesium homeostasis. ..
- Zartner P, Buettner M, Singer H, Sigler M. First biodegradable metal stent in a child with congenital heart disease: evaluation of macro and histopathology. Catheter Cardiovasc Interv. 2007;69:443-6 pubmed..This is an important precondition for further use of biodegradable stents in small infants. Further observations have to prove whether these findings do reproduce in other settings also. ..
- Martin T, Dietz H. Magnesium-free self-assembly of multi-layer DNA objects. Nat Commun. 2012;3:1103 pubmed publisher..Minimizing the fraction of such weakly binding strands by rational design choices enhanced the yield of folding. The results support the view that DNA-based nanodevices may be designed and produced for a variety of target environments. ..
- Mooren F, Turi S, Gunzel D, Schlue W, Domschke W, Singh J, et al. Calcium-magnesium interactions in pancreatic acinar cells. FASEB J. 2001;15:659-72 pubmed
- Fujita Becker S, Dürrwang U, Erent M, Clark R, Geeves M, Manstein D. Changes in Mg2+ ion concentration and heavy chain phosphorylation regulate the motor activity of a class I myosin. J Biol Chem. 2005;280:6064-71 pubmed..Our results indicate that higher concentrations of free Mg(2+) ions stabilize the tension-bearing actin myosin ADP state and shift the system from the production of rapid movement toward the generation of tension. ..
- Kremer W, Steiner G, Béraud Dufour S, Kalbitzer H. Conformational states of the small G protein Arf-1 in complex with the guanine nucleotide exchange factor ARNO-Sec7. J Biol Chem. 2004;279:17004-12 pubmed..GTP.Mg(2+) and is able to displace the bound GTP. ..
- Piller F, Bresser T, Fischer M, Knochel P. Preparation of functionalized cyclic enol phosphates by halogen-magnesium exchange and directed deprotonation reactions. J Org Chem. 2010;75:4365-75 pubmed publisher..Several optically pure enol phosphates were prepared starting from readily available d-(+)-camphor derivatives. ..
- Boehmer G, Greffrath W, Martin E, Hermann S. Subthreshold oscillation of the membrane potential in magnocellular neurones of the rat supraoptic nucleus. J Physiol. 2000;526 Pt 1:115-28 pubmed..Subthreshold oscillation of the membrane potential may be important for the inter-neuronal synchronization of discharge and for the amplification of synaptic events...
- Klunker D, Haas B, Hirtreiter A, Figueiredo L, Naylor D, Pfeifer G, et al. Coexistence of group I and group II chaperonins in the archaeon Methanosarcina mazei. J Biol Chem. 2003;278:33256-67 pubmed
- Persson T, Cuzic S, Hartmann R. Catalysis by RNase P RNA: unique features and unprecedented active site plasticity. J Biol Chem. 2003;278:43394-401 pubmed
- Schlingmann K, Sassen M, Weber S, Pechmann U, Kusch K, Pelken L, et al. Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia. J Am Soc Nephrol. 2005;16:3061-9 pubmed..This is best explained by a disturbed magnesium conservation in the distal convoluted tubule, which emerged in all patients upon magnesium supplementation. Delay of diagnosis resulted in permanent neurologic damage in three patients. ..
- Schlingmann K, Waldegger S, Konrad M, Chubanov V, Gudermann T. TRPM6 and TRPM7--Gatekeepers of human magnesium metabolism. Biochim Biophys Acta. 2007;1772:813-21 pubmed
- Bringmann A, Schopf S, Reichenbach A. Developmental regulation of calcium channel-mediated currents in retinal glial (Müller) cells. J Neurophysiol. 2000;84:2975-83 pubmed..The early and sole expression of transient currents at high-density may suggest that LVA Ca(2+) channels are involved in early developmental processes of rabbit Müller cells...
- Schmiedl A, Schmiedl P, Bonucci E, Seitz T, Schwille R, Manoharan M. Renal cortical calcification in syngeneic intact rats and those receiving an infrarenal thoracic aortic graft: possible etiological roles of endothelin, nitrate and minerals, and different preventive effects of long-term oral treatment with magnesium. Urol Res. 2001;29:229-37 pubmed..The significance of these findings for the etiology and treatment of clinical disorders with renal and vascular calcification is uncertain and requires further investigation. ..
- Rohdich F, Lauw S, Kaiser J, Feicht R, KOHLER P, Bacher A, et al. Isoprenoid biosynthesis in plants - 2C-methyl-D-erythritol-4-phosphate synthase (IspC protein) of Arabidopsis thaliana. FEBS J. 2006;273:4446-58 pubmed..The pH optimum is 8.0. NADH can substitute for NADPH, albeit at a low rate (14% as compared to NADPH). The enzyme catalyzes the reverse reaction at a rate of 2.1 micromol x min(-1) x mg(-1). ..
- Brantl S. Metal sensing by RNA in bacteria: exception or rule?. ACS Chem Biol. 2007;2:656-60 pubmed..Now, the discovery and in-depth characterization of a second metal-ion-sensing riboswitch that seems to be ubiquitously present in Gram-positive bacteria suggest that metal sensing by RNAs may represent a widespread mechanism. ..
- Rinnenthal J, Klinkert B, Narberhaus F, Schwalbe H. Modulation of the stability of the Salmonella fourU-type RNA thermometer. Nucleic Acids Res. 2011;39:8258-70 pubmed publisher..Binding of the two Mg(2+) ions exhibits a positive cooperativity with a Hill coefficient of 1.47. Free energy values ?G for Mg(2+) binding determined by NMR are in agreement with data determined from CD measurements. ..
- Westfahl C, Wolf P, Kamphues J. Estimation of inevitable macro mineral losses in amazons (Amazona spp.) as basis for the calculation of maintenance requirement. Arch Anim Nutr. 2009;63:75-85 pubmed publisher..4%), potassium (21.8%) and sodium (4.5%), whereas the calcium and phosphorus content in plasma stayed constant or did not show unidirectional changes in all animals...
- Cuzic Feltens S, Weber M, Hartmann R. Investigation of catalysis by bacterial RNase P via LNA and other modifications at the scissile phosphodiester. Nucleic Acids Res. 2009;37:7638-53 pubmed publisher..The presence of the protein cofactor suppressed the ground state binding defects, but not the catalytic defects. ..
- Seidl B, Huemer K, Neues F, Hild S, Epple M, Ziegler A. Ultrastructure and mineral distribution in the tergite cuticle of the beach isopod Tylos europaeus Arcangeli, 1938. J Struct Biol. 2011;174:512-26 pubmed publisher..Using thin sections of mineralised cuticle we describe for the first time that ACC forms tubes around single protein-chitin fibrils...
- Eggert K, von Wirén N. Dynamics and partitioning of the ionome in seeds and germinating seedlings of winter oilseed rape. Metallomics. 2013;5:1316-25 pubmed publisher..This study documents highly dynamic changes in the ionome of seed and seedling tissues and provides evidence for potentially limiting elements during early germination and seedling establishment in rapeseed. ..
- Contreras S, Meister P, Liu B, Prieto Mollar X, Hinrichs K, Khalili A, et al. Cyclic 100-ka (glacial-interglacial) migration of subseafloor redox zonation on the Peruvian shelf. Proc Natl Acad Sci U S A. 2013;110:18098-103 pubmed publisher..Such changes in subsurface biogeochemical zonation need to be taken into account to assess the role of the subseafloor biosphere in global element and redox cycling. ..
- Berchtold H, Reshetnikova L, Reiser C, Schirmer N, Sprinzl M, Hilgenfeld R. Crystal structure of active elongation factor Tu reveals major domain rearrangements. Nature. 1993;365:126-32 pubmed publisher..Comparison of the structure with that of EF-Tu-GDP reveals major mutual rearrangements of the three domains of the molecule...
- Gromadski K, Wieden H, Rodnina M. Kinetic mechanism of elongation factor Ts-catalyzed nucleotide exchange in elongation factor Tu. Biochemistry. 2002;41:162-9 pubmed..At in vivo concentrations of nucleotides and factors, the overall exchange rate, as calculated from the elemental rate constants, is 30 s(-1), which is compatible with the rate of protein synthesis in the cell. ..
- Gedrange T, Mai R, Richter G, Wolf P, Lupp A, Harzer W. X-ray microanalysis of elements in the masticatory muscle after paresis of the right masseter. J Dent Res. 2005;84:1026-30 pubmed..Botox((R)) has an indirect impact on ion concentrations, resulting in changes in muscle functional capacity and adaptive compensation of paretic muscle function by other muscles...
- Kilb W, Sinning A, Luhmann H. Model-specific effects of bumetanide on epileptiform activity in the in-vitro intact hippocampus of the newborn mouse. Neuropharmacology. 2007;53:524-33 pubmed..In summary, our results demonstrate that bumetanide exerts diverse effects in different in-vitro epilepsy models. ..
- Dorlöchter M, Irintchev A, Brinkers M, Wernig A. Effects of enhanced activity on synaptic transmission in mouse extensor digitorum longus muscle. J Physiol. 1991;436:283-92 pubmed..As a consequence, the safety margin of transmission in trained EDL muscles is markedly elevated. ..
- Pape T, Wintermeyer W, Rodnina M. Induced fit in initial selection and proofreading of aminoacyl-tRNA on the ribosome. EMBO J. 1999;18:3800-7 pubmed..As kinetically favored incorporation of the correct substrate has also been suggested for DNA and RNA polymerases, the present findings indicate that induced fit may contribute to the fidelity of template-programed systems in general. ..
- Weber S, Schneider L, Peters M, Misselwitz J, Rönnefarth G, Böswald M, et al. Novel paracellin-1 mutations in 25 families with familial hypomagnesemia with hypercalciuria and nephrocalcinosis. J Am Soc Nephrol. 2001;12:1872-81 pubmed..In 13 of 23 families, hypercalciuria and/or nephrolithiasis were observed in otherwise unaffected family members, indicating a possible role of heterozygous PCLN-1 mutations in yielding hypercalciuric stone-forming conditions...
- Ziegler A. X-ray microprobe analysis of epithelial calcium transport. Cell Calcium. 2002;31:307-21 pubmed..Organelles, probably the smooth endoplasmic reticulum, sequester Ca(2+) during intracellular Ca(2+)-transport. A role of mitochondria as a storage site for cuticular Ca is excluded...
- Carrillo Nava E, Mejía Radillo Y, Hinz H. Dodecamer DNA duplex formation is characterized by second-order kinetics, positive activation energies, and a dependence on sequence and Mg2+ ion concentration. Biochemistry. 2008;47:13153-7 pubmed..The dependence on sequence of the kinetics of hybridization was manifest in all parameters under all the experimental conditions...
- Feyerabend F, Fischer J, Holtz J, Witte F, Willumeit R, Drücker H, et al. Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines. Acta Biomater. 2010;6:1834-42 pubmed publisher..The focus of magnesium alloy development for biomedical applications should include most defined alloy compositions with well-known tissue-specific and systemic effects...
- Schwanstecher C, Dickel C, Panten U. Interaction of tolbutamide and cytosolic nucleotides in controlling the ATP-sensitive K+ channel in mouse beta-cells. Br J Pharmacol. 1994;111:302-10 pubmed..The latter effect increases the proportion of KATP- channels staying in the nucleotide-blocked state. In addition, this state potentiates the direct effect of sulphonylureas. ..
- Petroianu G, Liu J, Helfrich U, Maleck W, Rufer R. Phospholipase A2-induced coagulation abnormalities after bee sting. Am J Emerg Med. 2000;18:22-7 pubmed..They cannot be recommended at this stage for this purpose. Further investigations with competitive PLA2-inhibitors are warranted. ..
- Ebel H, Hollstein M, Gunther T. Role of the choline exchanger in Na(+)-independent Mg(2+) efflux from rat erythrocytes. Biochim Biophys Acta. 2002;1559:135-44 pubmed..Inhibition of choline efflux and of Mg(2+) efflux in choline medium occurred as follows: quinine>cinchonine>HC-3>DoTMA. Mg(2+) efflux was reduced to the same degree by these inhibitors as was the [(14)C]choline efflux...
- Schlee S, Deuss M, Bruning M, Ivens A, Schwab T, Hellmann N, et al. Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release . Biochemistry. 2009;48:5199-209 pubmed publisher..This effect appears to be mainly caused by an increased conformational flexibility induced by the F149S mutation, a hypothesis which is supported by the reduced thermal stability of the ssAnPRT-F149S single mutant...
- Roland L, Grau M, Matena J, Teske M, Gieseke M, Kampmann A, et al. Poly-Îµ-caprolactone Coated and Functionalized Porous Titanium and Magnesium Implants for Enhancing Angiogenesis in Critically Sized Bone Defects. Int J Mol Sci. 2015;17: pubmed publisher..Incorporated concentrations of proangiogenic factors were probably too low, as they did not lead to any effect. Magnesium implants did not yield evaluable results, as they led to pH increase and subsequent cell death. ..
- Frings S, Brüll N, Dzeja C, Angele A, Hagen V, Kaupp U, et al. Characterization of ether-à-go-go channels present in photoreceptors reveals similarity to IKx, a K+ current in rod inner segments. J Gen Physiol. 1998;111:583-99 pubmed..Comparison of EAG currents with IKx, a noninactivating K+ current in the inner segment of rod photoreceptors, reveals an intriguing similarity, suggesting that EAG polypeptides are involved in the formation of Kx channels. ..
- Hofmann K, Tomiuk S, Wolff G, Stoffel W. Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase. Proc Natl Acad Sci U S A. 2000;97:5895-900 pubmed..Both mammalian nSMases are members of a superfamily of Mg(2+)-dependent phosphohydrolases, which also contains nucleases, inositol phosphatases, and bacterial toxins. ..
- Raaijmakers H, Toro I, Birkenbihl R, Kemper B, Suck D. Conformational flexibility in T4 endonuclease VII revealed by crystallography: implications for substrate binding and cleavage. J Mol Biol. 2001;308:311-23 pubmed..A comparison with the active-site geometries of other magnesium-dependent nucleases, among them the homing endonuclease I-PpoI and Serratia endonuclease, shows common features, suggesting related catalytic mechanisms. ..
- El Faramawy N, Göksu H, Panzer W. Thermoluminescence dosimetric properties of a new thin beta detector (LiF:Mg, Cu, P; GR-200F) in comparison with highly sensitive Al2O3:C beta dosimeters. J Radiol Prot. 2004;24:273-82 pubmed..The photon energy responses of the detectors are investigated using 150 keV filtered x-rays and 60Co gamma-rays. ..
- Musset B, Meuth S, Liu G, Derst C, Wegner S, Pape H, et al. Effects of divalent cations and spermine on the K+ channel TASK-3 and on the outward current in thalamic neurons. J Physiol. 2006;572:639-57 pubmed..We conclude from our results that inhibition of TASK-3 channels may contribute to the neuromodulatory effect of spermine released from neurons during repetitive activity or during hypoxia. ..
- Blume A, Berger M, Benie A, Peters T, Hinderlich S. Characterization of ligand binding to N-acetylglucosamine kinase studied by STD NMR. Biochemistry. 2008;47:13138-46 pubmed publisher..The high beta anomeric preference of GlcNAc kinase along with the drastically reduced binding affinity for sugars other than GlcNAc, suggests that GlcNAc kinase phosphorylates beta-GlcNAc in cells. ..
- Hardt W, Schlegl J, Erdmann V, Hartmann R. Gel retardation analysis of E. coli M1 RNA-tRNA complexes. Nucleic Acids Res. 1993;21:3521-7 pubmed..This indicates that tight binding of the tRNA to the catalytic RNA at higher magnesium concentrations retards product release and therefore substrate turnover. ..
- Niefind K, Guerra B, Pinna L, Issinger O, Schomburg D. Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution. EMBO J. 1998;17:2451-62 pubmed..This finding explains the observation that CK2, unlike other protein kinases, can use both ATP and GTP as phosphorylating agents. ..
- Pfeiffer J, Guhl J, Waidner B, Kist M, Bereswill S. Magnesium uptake by CorA is essential for viability of the gastric pathogen Helicobacter pylori. Infect Immun. 2002;70:3930-4 pubmed..pylori. The drastic Mg(2+) requirement (20 mM) of H. pylori corA mutants indicates that CorA plays a key role in the adaptation to the low-Mg(2+) conditions predominant in the gastric environment...
- Hofmann T, Chubanov V, Chen X, Dietz A, Gudermann T, Montell C. Drosophila TRPM channel is essential for the control of extracellular magnesium levels. PLoS ONE. 2010;5:e10519 pubmed publisher..These data provide the first evidence for a role for a Drosophila TRP channel in Mg2+ homeostasis, and underscore a broad and evolutionarily conserved role for TRPM channels in Mg2+ homeostasis...
- Hornberger H, Virtanen S, Boccaccini A. Biomedical coatings on magnesium alloys - a review. Acta Biomater. 2012;8:2442-55 pubmed publisher..In addition to biocompatibility, the mechanical properties of the coatings are also relevant, and the development of appropriate methods to study the corrosion process in detail and in the long term remains an important area of research...
- Yang L, Ma L, Huang Y, Feyerabend F, Blawert C, Höche D, et al. Influence of Dy in solid solution on the degradation behavior of binary Mg-Dy alloys in cell culture medium. Mater Sci Eng C Mater Biol Appl. 2017;75:1351-1358 pubmed publisher..This can be attributed to the formation of a relatively more corrosion resistant Dy-enriched film which decreases the anodic dissolution of Mg. ..
- Lancaster C, Bibikova M, Sabatino P, Oesterhelt D, Michel H. Structural basis of the drastically increased initial electron transfer rate in the reaction center from a Rhodopseudomonas viridis mutant described at 2.00-A resolution. J Biol Chem. 2000;275:39364-8 pubmed..The high quality of the electron density maps also allowed a reliable discussion of the mode of binding of the triazine herbicide terbutryn at the binding site of the secondary quinone, Q(B)...
- Scheideler L, Füger C, Schille C, Rupp F, Wendel H, Hort N, et al. Comparison of different in vitro tests for biocompatibility screening of Mg alloys. Acta Biomater. 2013;9:8740-5 pubmed publisher..We suppose that this test system has the potential to enhance the predictability of in vivo corrosion behaviour and biocompatibility of Mg-based materials for biodegradable medical devices. ..
- Lukatela G, Krauss N, Theis K, Selmer T, Gieselmann V, Von Figura K, et al. Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis. Biochemistry. 1998;37:3654-64 pubmed..This study provides the structural basis for understanding a novel mechanism of ester hydrolysis and explains the functional importance of the unusually modified amino acid. ..
- Orth P, Saenger W, Hinrichs W. Tetracycline-chelated Mg2+ ion initiates helix unwinding in Tet repressor induction. Biochemistry. 1999;38:191-8 pubmed publisher..They simultaneously close the tunnel entrance and cause the DNA-binding domains to adopt a nonbinding conformation, leading to release of operator DNA and expression of the genes responsible for resistance...
- Schipke C, Ohlemeyer C, Matyash M, Nolte C, Kettenmann H, Kirchhoff F. Astrocytes of the mouse neocortex express functional N-methyl-D-aspartate receptors. FASEB J. 2001;15:1270-2 pubmed
- Gómez Merino F, Brearley C, Ornatowska M, Abdel Haliem M, Zanor M, Mueller Roeber B. AtDGK2, a novel diacylglycerol kinase from Arabidopsis thaliana, phosphorylates 1-stearoyl-2-arachidonoyl-sn-glycerol and 1,2-dioleoyl-sn-glycerol and exhibits cold-inducible gene expression. J Biol Chem. 2004;279:8230-41 pubmed..We found that AtDGK2 is induced by exposure to low temperature (4 degrees C), pointing to a role in cold signal transduction. ..
- Gruegelsiepe H, Brandt O, Hartmann R. Antisense inhibition of RNase P: mechanistic aspects and application to live bacteria. J Biol Chem. 2006;281:30613-20 pubmed
- Mederos y Schnitzler M, Wäring J, Gudermann T, Chubanov V. Evolutionary determinants of divergent calcium selectivity of TRPM channels. FASEB J. 2008;22:1540-51 pubmed..Overall, our findings provide an integrative view on the evolution of the domain architecture and the structural basis of the distinct ion permeation profiles of TRPM channels. ..
- Kolisek M, Launay P, Beck A, Sponder G, Serafini N, Brenkus M, et al. SLC41A1 is a novel mammalian Mg2+ carrier. J Biol Chem. 2008;283:16235-47 pubmed publisher..SLC41A1 activity is temperature-sensitive but not sensitive to the only known magnesium channel blocker, cobalt(III) hexaammine. Taken together, these data functionally identify SLC41A1 as a mammalian carrier mediating magnesium efflux. ..
- Gebert M, Meschenmoser K, Svidova S, Weghuber J, Schweyen R, Eifler K, et al. A root-expressed magnesium transporter of the MRS2/MGT gene family in Arabidopsis thaliana allows for growth in low-Mg2+ environments. Plant Cell. 2009;21:4018-30 pubmed publisher..Hence, contrary to what is frequently found in analyses of plant gene families, a single gene family member knockout results in a strong, environmentally dependent phenotype. ..
- Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science. 1992;256:1217-21 pubmed..Such heteromeric NMDA receptor subtypes may exist in neurons, since NR1 messenger RNA is synthesized throughout the mature rat brain, while NR2 messenger RNA show a differential distribution. ..
- Gudermann T, Birnbaumer M, Birnbaumer L. Homologous desensitization of the murine luteinizing hormone receptor expressed in L cells. Mol Cell Endocrinol. 1995;110:125-35 pubmed..Thus, it is likely that a second messenger-independent kinase, such as beta-adrenergic receptor kinase, or a different, as yet unknown mechanism is involved in the agonist-induced desensitization of the LH receptor. ..
- Niefind K, Pütter M, Guerra B, Issinger O, Schomburg D. GTP plus water mimic ATP in the active site of protein kinase CK2. Nat Struct Biol. 1999;6:1100-3 pubmed..An understanding of the structural basis of dual-cosubstrate specificity may help in the design of drugs that target CK2 or other kinases with this property. ..
- Grabarse W, Mahlert F, Duin E, Goubeaud M, Shima S, Thauer R, et al. On the mechanism of biological methane formation: structural evidence for conformational changes in methyl-coenzyme M reductase upon substrate binding. J Mol Biol. 2001;309:315-30 pubmed publisher..The three different enzymatically inactive enzyme states are discussed with respect to their enzymatically active precursors and with respect to the catalytic mechanism...
- Alber B, Fuchs G. Propionyl-coenzyme A synthase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation. J Biol Chem. 2002;277:12137-43 pubmed..g. polyketide synthases) but rare in primary metabolism (e.g. eukaryotic type I fatty acid synthase). These results lend strong support to the operation of the proposed pathway in autotrophic CO(2) fixation. ..
- Schuchmann S, Meierkord H, Stenkamp K, Breustedt J, Windmüller O, Heinemann U, et al. Synaptic and nonsynaptic ictogenesis occurs at different temperatures in submerged and interface rat brain slices. J Neurophysiol. 2002;87:2929-35 pubmed..The results of the study indicate that gas-liquid interface and total-liquid submerged slice states impart distinct physiological parameters on brain tissue...
- Mayans O, Ivens A, Nissen L, Kirschner K, Wilmanns M. Structural analysis of two enzymes catalysing reverse metabolic reactions implies common ancestry. EMBO J. 2002;21:3245-54 pubmed..These relationships establish new links for enzymes involved in nucleotide and amino acid metabolism. ..
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