Experts and Doctors on longevity in Spain


Locale: Spain
Topic: longevity

Top Publications

  1. Juan Jordá M, Mosqueira I, Freire J, Dulvy N. The conservation and management of tunas and their relatives: setting life history research priorities. PLoS ONE. 2013;8:e70405 pubmed publisher
  2. Sanchis Gomar F, Gomez Cabrera M, Vina J. The loss of muscle mass and sarcopenia: non hormonal intervention. Exp Gerontol. 2011;46:967-9 pubmed publisher
    ..Moreover, any significant improvement in the loss of muscle function will be a major breakthrough in the health and welfare of the population. ..
  3. Surco Laos F, Cabello J, Gomez Orte E, Gonzalez Manzano S, González Paramás A, Santos Buelga C, et al. Effects of O-methylated metabolites of quercetin on oxidative stress, thermotolerance, lifespan and bioavailability on Caenorhabditis elegans. Food Funct. 2011;2:445-56 pubmed publisher
    ..Quantification of the levels of quercetin, isorhamnetin and tamarixetin, as well as their detected metabolites indicated a greater uptake of quercetin than its methylated derivatives by the nematode. ..
  4. Bello R, Gómez Díaz C, Burón M, Alcain F, Navas P, Villalba J. Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet. Exp Gerontol. 2005;40:694-706 pubmed
    ..The possibility that a decreased CoQ9/CoQ10 ratio in animals fed on the PUFAn-6-rich plus CoQ10 diet could also influence longevity is also discussed. ..
  5. Sánchez Fidalgo S, Villegas I, Sanchez Hidalgo M, de la Lastra C. Sirtuin modulators: mechanisms and potential clinical implications. Curr Med Chem. 2012;19:2414-41 pubmed
    ..This review is intended to provide an appreciation of the possible protection against aging-associated diseases by these enzymes, summarize novel underlying mechanisms and evaluate potential clinical applications. ..
  6. Gimenez Llort L, Arranz L, Maté I, De la Fuente M. Gender-specific neuroimmunoendocrine aging in a triple-transgenic 3xTg-AD mouse model for Alzheimer's disease and its relation with longevity. Neuroimmunomodulation. 2008;15:331-43 pubmed publisher
    ..The results also show the relevance of gender differences that should be taken into consideration in both basic and clinical research for assessing new strategies for the control of AD. ..
  7. Herranz D, Muñoz Martin M, Canamero M, Mulero F, Martinez Pastor B, Fernandez Capetillo O, et al. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun. 2010;1:3 pubmed publisher
    ..Together, these results provide direct proof of the anti-ageing activity of Sirt1 in mammals and of its tumour suppression activity in ageing- and metabolic syndrome-associated cancer. ..
  8. Alis R, Santos Lozano A, Sanchis Gomar F, Pareja Galeano H, Fiuza Luces C, Garatachea N, et al. Trace elements levels in centenarian 'dodgers'. J Trace Elem Med Biol. 2016;35:103-6 pubmed publisher
    ..These results should be confirmed in larger cohorts of other geographic/ethnic origin and the potential cause-effect association tested in mechanistic experimental settings. ..
  9. Mourocq E, Bize P, Bouwhuis S, Bradley R, Charmantier A, De La Cruz C, et al. Life span and reproductive cost explain interspecific variation in the optimal onset of reproduction. Evolution. 2016;70:296-313 pubmed publisher
    ..By providing the first empirical confirmations of key predictions of life-history theory across species, this study contributes to a better understanding of life-history evolution. ..

More Information


  1. Anadón A, Martínez Larrañaga M, Martinez M, Ares I, Ramos E, Gómez Cortés P, et al. Acute oral safety study of dairy fat rich in trans-10 C18:1 versus vaccenic plus conjugated linoleic acid in rats. Food Chem Toxicol. 2010;48:591-8 pubmed publisher
    ..Our results suggest that the T10 milk fat treatment tended to increase triglycerides concentrations, whereas the T11-CLA milk fat treatment tended to reduce it. ..
  2. Herrera E, Samper E, Martin Caballero J, Flores J, Lee H, Blasco M. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 1999;18:2950-60 pubmed
    ..These results indicate that telomere shortening in mTR-/- mice leads to progressive loss of organismal viability. ..
  3. Ortega Molina A, Efeyan A, Lopez Guadamillas E, Muñoz Martin M, Gomez Lopez G, Canamero M, et al. Pten positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab. 2012;15:382-94 pubmed publisher
    ..These observations uncover a role of Pten in promoting energy expenditure, thus decreasing nutrient storage and its associated damage. ..
  4. Arranz L, Caamano J, Lord J, De la Fuente M. Preserved immune functions and controlled leukocyte oxidative stress in naturally long-lived mice: possible role of nuclear factor kappa B. J Gerontol A Biol Sci Med Sci. 2010;65:941-50 pubmed publisher
  5. Fiuza Luces C, Ruiz J, Rodríguez Romo G, Santiago C, Gomez Gallego F, Cano Nieto A, et al. Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort. J Renin Angiotensin Aldosterone Syst. 2011;12:202-7 pubmed publisher
    ..Further research is, however, necessary using other approaches. It also remains to be determined if the interaction of ACE genotypes with some other genetic variants exerts a potential effect on longevity. ..
  6. Borras C, Monleon D, López Grueso R, Gambini J, Orlando L, Pallardo F, et al. RasGrf1 deficiency delays aging in mice. Aging (Albany NY). 2011;3:262-76 pubmed
    ..Our observations link Ras signaling to lifespan and suggest that RasGrf1 is an evolutionary conserved gene which could be targeted for the development of therapies to delay age-related processes. ..
  7. Adán C, Matsushima Y, Hernández Sierra R, Marco Ferreres R, Fernández Moreno M, Gonzalez Vioque E, et al. Mitochondrial transcription factor B2 is essential for metabolic function in Drosophila melanogaster development. J Biol Chem. 2008;283:12333-42 pubmed publisher
  8. Muñoz Antoli C, Marin A, Toledo R, Esteban J. Effect of Echinostoma friedi (Trematoda: Echinostomatidae) experimental infection on longevity, growth and fecundity of juvenile Radix peregra (Gastropoda: Lymnaeidae) and Biomphalaria glabrata (Gastropoda: Planorbidae) snails. Parasitol Res. 2007;101:1663-70 pubmed
    ..E. friedi produces a total parasitic castration of R. peregra and B. glabrata INF snails. R. peregra would be considered as the required snail host, while B. glabrata only as an adequate snail host...
  9. Monje J, Brokate Llanos A, Pérez Jiménez M, Fidalgo M, Munoz M. pkc-1 regulates daf-2 insulin/IGF signalling-dependent control of dauer formation in Caenorhabditis elegans. Aging Cell. 2011;10:1021-31 pubmed publisher
    ..pkc-1 belongs to the novel protein kinase C (nPKC) family, members of which have been implicated in insulin resistance and diabetes in mammals, suggesting a conserved role for pkc-1 in the regulation of the insulin/IGF pathway. ..
  10. Sanchez D, López Arias B, Torroja L, Canal I, Wang X, Bastiani M, et al. Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila. Curr Biol. 2006;16:680-6 pubmed this issue of Current Biology), who analyze the effects of overexpressing GLaz, we conclude that GLaz has a protective role in stress situations and that its absence reduces lifespan and accelerates neurodegeneration. ..
  11. Serra Majem L, Roman B, Estruch R. Scientific evidence of interventions using the Mediterranean diet: a systematic review. Nutr Rev. 2006;64:S27-47 pubmed
    ..Further experimental research is needed to corroborate the benefits of the Mediterranean diet and the underlying mechanisms, and in this sense the methodology of the ongoing PREDIMED study is explained. ..
  12. Espejel S, Klatt P, Menissier de Murcia J, Martin Caballero J, Flores J, Taccioli G, et al. Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs. J Cell Biol. 2004;167:627-38 pubmed
    ..These results support the notion that absence of telomerase and short telomeres in combination with DNA repair deficiencies accelerate the aging process without impacting on tumorigenesis. ..
  13. Asencio C, Rodríguez Aguilera J, Ruiz Ferrer M, Vela J, Navas P. Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans. FASEB J. 2003;17:1135-7 pubmed
    ..elegans. ..
  14. Pamplona R, Portero Otin M, Riba D, Ledo F, Gredilla R, Herrero A, et al. Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse. Aging (Milano). 1999;11:44-9 pubmed
  15. Scialò F, Sriram A, Fernández Ayala D, Gubina N, Lõhmus M, Nelson G, et al. Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metab. 2016;23:725-34 pubmed publisher
    ..These results illustrate that the source of a ROS signal is vital in determining its effects on cellular physiology and establish that manipulation of ubiquinone redox state is a valid strategy to delay aging. ..