Experts and Doctors on longevity in Finland


Locale: Finland
Topic: longevity

Top Publications

  1. Sanz A, Stefanatos R. The mitochondrial free radical theory of aging: a critical view. Curr Aging Sci. 2008;1:10-21 pubmed
    ..g. insulin signalling). If MFRTA is true animals producing fewer mtROS must have the ability to live much longer than their experimental controls. ..
  2. Pertovaara M, Raitala A, Lehtimaki T, Karhunen P, Oja S, Jylha M, et al. Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality. Mech Ageing Dev. 2006;127:497-9 pubmed
    ..Thus, increased IDO activity might be a mechanism involved in the decline of T cell responses in immunosenescence. ..
  3. Karlsson S. Histopathology and histomorphometry of the urogenital tract in 15-month old male and female rats treated neonatally with SERMs and estrogens. Exp Toxicol Pathol. 2006;58:1-12 pubmed
    ..In conclusion, the vas deferens is a main target organ following neonatal administration of SERMs and estrogens. In addition, female rats were significantly more susceptible to SERM treatment than to treatment with estrogens. ..
  4. Katajisto P, Vaahtomeri K, Ekman N, Ventelä E, Ristimaki A, Bardeesy N, et al. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nat Genet. 2008;40:455-9 pubmed publisher
    ..We also noted TGFbeta signaling defects in polyps of individuals with PJS, suggesting that the identified stromal-derived mechanism of tumor suppression is also relevant in PJS. ..
  5. Jylhävä J, Eklund C, Jylha M, Hervonen A, Lehtimaki T, Karhunen P, et al. Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study. Exp Gerontol. 2009;44:297-9 pubmed publisher
    ..016). We propose that the increased mortality is inflammation-related and mediated by aberrant complement regulation by the CFH 402His variant. ..
  6. Sanz A, Soikkeli M, Portero Otin M, Wilson A, Kemppainen E, McIlroy G, et al. Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. Proc Natl Acad Sci U S A. 2010;107:9105-10 pubmed publisher
    ..Our results support a central role of mitochondrial oxidative phosphorylation complex I in influencing longevity via oxidative stress, independently of pathways connected to nutrition and growth signaling. ..
  7. Sanz A, Fernandez Ayala D, Stefanatos R, Jacobs H. Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila. Aging (Albany NY). 2010;2:200-23 pubmed
    ..In summary, these results do not systematically support the predictions of the MFRTA. Accordingly, MFRTA should be revised to accommodate these findings. ..
  8. Niitepõld K, Hanski I. A long life in the fast lane: positive association between peak metabolic rate and lifespan in a butterfly. J Exp Biol. 2013;216:1388-97 pubmed publisher
    ..Generalisations such as 'live fast, die young' may be too simple to explain the complex processes affecting ageing and lifespan. ..
  9. Suppola S, Heikkinen S, Parkkinen J, Uusi Oukari M, Korhonen V, Keinanen T, et al. Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice. Biochem J. 2001;358:343-8 pubmed

More Information


  1. Scialò F, Sriram A, Fernández Ayala D, Gubina N, Lõhmus M, Nelson G, et al. Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metab. 2016;23:725-34 pubmed publisher
    ..These results illustrate that the source of a ROS signal is vital in determining its effects on cellular physiology and establish that manipulation of ubiquinone redox state is a valid strategy to delay aging. ..