Experts and Doctors on lipoprotein receptors in Germany


Locale: Germany
Topic: lipoprotein receptors

Top Publications

  1. Kiefer C, Sumser E, Wernet M, von Lintig J. A class B scavenger receptor mediates the cellular uptake of carotenoids in Drosophila. Proc Natl Acad Sci U S A. 2002;99:10581-6 pubmed
  2. Hogger P, Dreier J, Droste A, Buck F, Sorg C. Identification of the integral membrane protein RM3/1 on human monocytes as a glucocorticoid-inducible member of the scavenger receptor cysteine-rich family (CD163). J Immunol. 1998;161:1883-90 pubmed
    ..Taken together with a previous result showing an involvement of RM3/1 in adhesion of monocytes to the activated endothelium, we discuss that CD163 might play an important role in inflammatory processes. ..
  3. Janssen K, Rost R, Eichinger L, Schleicher M. Characterization of CD36/LIMPII homologues in Dictyostelium discoideum. J Biol Chem. 2001;276:38899-910 pubmed
    ..These features make them promising candidates as a paradigm for the study of the function and evolution of the as yet poorly understood CD36/LIMPII proteins. ..
  4. Wolf G, Wenzel U, Jablonski K, Brundert M, Rinninger F. Angiotensin II down-regulates the SR-BI HDL receptor in proximal tubular cells. Nephrol Dial Transplant. 2005;20:1222-7 pubmed
    ..ANG II-mediated suppression may contribute to various pathophysiological situations, such as acute tubular injury, the nephrotic syndrome and atherosclerosis. ..
  5. Weiss K, Johanssen C, Tielsch A, Herz J, Deller T, Frotscher M, et al. Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice. J Comp Neurol. 2003;460:56-65 pubmed
    ..Our results suggest that Reelin signaling via ApoER2, VLDLR, and Dab1 is required for the formation of a regular radial glial scaffold in the dentate gyrus. ..
  6. Kosacka J, Gericke M, Nowicki M, Kacza J, Borlak J, Spanel Borowski K. Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures. Neuroscience. 2009;162:282-91 pubmed publisher
    ..We thus assume that apolipoprotein-induced neuritogenesis in DRG cells interferes with CXCR4 signaling, and that adipocyte-derived apolipoproteins might be helpful in nerve repair. ..
  7. Hack I, Hellwig S, Junghans D, Brunne B, Bock H, Zhao S, et al. Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. Development. 2007;134:3883-91 pubmed
    ..We present evidence for divergent roles of the two reelin receptors Vldlr and ApoER2, with Vldlr mediating a stop signal for migrating neurons and ApoER2 being essential for the migration of late generated neocortical neurons. ..
  8. Andersen O, Willnow T. Lipoprotein receptors in Alzheimer's disease. Trends Neurosci. 2006;29:687-94 pubmed
  9. Zhao S, Chai X, Bock H, Brunne B, Forster E, Frotscher M. Rescue of the reeler phenotype in the dentate gyrus by wild-type coculture is mediated by lipoprotein receptors for Reelin and Disabled 1. J Comp Neurol. 2006;495:1-9 pubmed

More Information


  1. Andersen O, Benhayon D, Curran T, Willnow T. Differential binding of ligands to the apolipoprotein E receptor 2. Biochemistry. 2003;42:9355-64 pubmed
    ..This finding indicates that aggregation of apoER2 by multivalent ligands such as Reelin may be the structural basis for signal transduction. ..
  2. Andersen O, Yeung C, Vorum H, Wellner M, Andreassen T, Erdmann B, et al. Essential role of the apolipoprotein E receptor-2 in sperm development. J Biol Chem. 2003;278:23989-95 pubmed
  3. Langer C, Gansz B, Goepfert C, Engel T, Uehara Y, von Dehn G, et al. Testosterone up-regulates scavenger receptor BI and stimulates cholesterol efflux from macrophages. Biochem Biophys Res Commun. 2002;296:1051-7 pubmed
    ..These data suggest that testosterone, despite lowering HDL cholesterol, intensifies reverse cholesterol transport and thereby exerts an anti-atherogenic rather than a pro-atherogenic effect...
  4. Haas C, Dudeck O, Kirsch M, Huszka C, Kann G, Pollak S, et al. Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. J Neurosci. 2002;22:5797-802 pubmed
    ..These results suggest that reelin is required for normal neuronal lamination in humans, and that deficient reelin expression may be involved in migration defects associated with temporal lobe epilepsy. ..
  5. Gebhardt C, Del Turco D, Drakew A, Tielsch A, Herz J, Frotscher M, et al. Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice. J Comp Neurol. 2002;445:278-92 pubmed
    ..These data provide further evidence for a role of granule cells in the laminar termination of commissural/associational afferents to the fascia dentata. ..
  6. Drobnik W, Lindenthal B, Lieser B, Ritter M, Christiansen Weber T, Liebisch G, et al. ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism. Gastroenterology. 2001;120:1203-11 pubmed
    ..Our aim was to further analyze the role of ABCA1 in cholesterol metabolism...
  7. Kerkhoff C, Sorg C, Tandon N, Nacken W. Interaction of S100A8/S100A9-arachidonic acid complexes with the scavenger receptor CD36 may facilitate fatty acid uptake by endothelial cells. Biochemistry. 2001;40:241-8 pubmed
    ..Therefore, it can be envisioned that their interaction might propagate host response by perpetuating recruitment and activation of cellular effectors. ..
  8. Buechler C, Ritter M, Orso E, Langmann T, Klucken J, Schmitz G. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. J Leukoc Biol. 2000;67:97-103 pubmed
    ..This expression pattern implies a functional role of CD 163 in the antiinflammatory response of monocytes. ..
  9. Droste A, Sorg C, Hogger P. Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family. Biochem Biophys Res Commun. 1999;256:110-3 pubmed
    ..These results indicate a specific release mechanism of soluble CD163 by human monocytes which could play an important role in modulating inflammatory processes. ..
  10. Lohrke B, Viergutz T, Kruger B. Polar phospholipids from bovine endogenously oxidized low density lipoprotein interfere with follicular thecal function. J Mol Endocrinol. 2005;35:531-45 pubmed
  11. Stolt P, Bock H. Modulation of lipoprotein receptor functions by intracellular adaptor proteins. Cell Signal. 2006;18:1560-71 pubmed
  12. Chai X, Forster E, Zhao S, Bock H, Frotscher M. Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3. J Neurosci. 2009;29:288-99 pubmed publisher
    ..These novel findings suggest that Reelin-induced stabilization of neuronal processes anchors them to the marginal zone which appears to be required for the directional migration process. ..