Experts and Doctors on lipid bilayers in Germany


Locale: Germany
Topic: lipid bilayers

Top Publications

  1. Zitzer A, Bittman R, Verbicky C, Erukulla R, Bhakdi S, Weis S, et al. Coupling of cholesterol and cone-shaped lipids in bilayers augments membrane permeabilization by the cholesterol-specific toxins streptolysin O and Vibrio cholerae cytolysin. J Biol Chem. 2001;276:14628-33 pubmed
    ..Instead, lipids that have a conical molecular shape appear to effect a change in the energetic state of membrane cholesterol that in turn augments the interaction of the sterol with the cholesterol-specific cytolysins. ..
  2. Spaar A, Salditt T. Short range order of hydrocarbon chains in fluid phospholipid bilayers studied by x-ray diffraction from highly oriented membranes. Biophys J. 2003;85:1576-84 pubmed
    ..Heller, M. Schaefer, and K. Schulten. 1993. J. Phys. Chem. 97:8343-8360) by direct Fourier transformation of the atomic coordinates. The exact prefactor in the relationship between interchain distance and peak position is derived. ..
  3. Huster D, Scheidt H, Arnold K, Herrmann A, Muller P. Desmosterol may replace cholesterol in lipid membranes. Biophys J. 2005;88:1838-44 pubmed
    ..Our results show that, from the point of view of membrane biophysics, cholesterol and desmosterol behave identically and, therefore, replacement of cholesterol by desmosterol may not impact organism homeostasis. ..
  4. Brauser A, Schroeder I, Gutsmann T, Cosentino C, Moroni A, Hansen U, et al. Modulation of enrofloxacin binding in OmpF by Mg2+ as revealed by the analysis of fast flickering single-porin current. J Gen Physiol. 2012;140:69-82 pubmed publisher
    ..The voltage dependence suggests that the dipole of the antibiotic has to be adequately oriented to facilitate binding. ..
  5. Orlik F, Andersen C, Benz R. Site-directed mutagenesis of tyrosine 118 within the central constriction site of the LamB (maltoporin) channel of Escherichia coli. II. Effect on maltose and maltooligosaccharide binding kinetics. Biophys J. 2002;83:309-21 pubmed
    ..The results suggest that tyrosine 118 has a crucial effect on carbohydrate transport through LamB. ..
  6. Jenske R, Lindström F, Gröbner G, Vetter W. Impact of free hydroxylated and methyl-branched fatty acids on the organization of lipid membranes. Chem Phys Lipids. 2008;154:26-32 pubmed publisher
    ..In both cases, the pure enantiomers alleviated the liquid-crystalline state of the biological model membrane. ..
  7. Klein M, Grage S, Muhle Goll C, Bürck J, Afonin S, Ulrich A. Structure analysis of the membrane-bound PhoD signal peptide of the Tat translocase shows an N-terminal amphiphilic helix. Biochim Biophys Acta. 2012;1818:3025-31 pubmed publisher
    ..Based on our new structural insights, we propose a model for the folding and membrane interactions of the Tat signal sequence from PhoD. ..
  8. Langecker M, Arnaut V, Martin T, List J, Renner S, Mayer M, et al. Synthetic lipid membrane channels formed by designed DNA nanostructures. Science. 2012;338:932-6 pubmed publisher
    ..Single-molecule translocation experiments show that the synthetic channels can be used to discriminate single DNA molecules. ..
  9. Harsman A, Kopp A, Wagner R, Zimmermann R, Jung M. Calmodulin regulation of the calcium-leak channel Sec61 is unique to vertebrates. Channels (Austin). 2011;5:293-8 pubmed
    ..Therefore, CaM binding to the cytosolic N-terminus of Sec61? is involved in limiting Ca(2+)-leakage from the ER in C. familiaris but not S. cerevisiae. ..

More Information

Publications121 found, 100 shown here

  1. Zhao W, Rog T, Gurtovenko A, Vattulainen I, Karttunen M. Role of phosphatidylglycerols in the stability of bacterial membranes. Biochimie. 2008;90:930-8 pubmed publisher
    ..A more compact and less dynamic interface structure also decreases membrane permeability. That provides a possible mechanism for stabilizing, e.g., bacterial membranes. ..
  2. Patel G, Kleinschmidt J. The lipid bilayer-inserted membrane protein BamA of Escherichia coli facilitates insertion and folding of outer membrane protein A from its complex with Skp. Biochemistry. 2013;52:3974-86 pubmed publisher
  3. Purrucker O, Förtig A, Jordan R, Tanaka M. Supported membranes with well-defined polymer tethers--incorporation of cell receptors. Chemphyschem. 2004;5:327-35 pubmed
  4. Hakobyan D, Heuer A. Phase separation in a lipid/cholesterol system: comparison of coarse-grained and united-atom simulations. J Phys Chem B. 2013;117:3841-51 pubmed publisher
    ..From the structural perspective, the phase separation process appears to be rather similar for both models, which illustrates once more the power of using CG approaches. ..
  5. Benz R, Maier E, Gentschev I. TolC of Escherichia coli functions as an outer membrane channel. Zentralbl Bakteriol. 1993;278:187-96 pubmed
    ..A dissociation constant of 20 mM was calculated for the binding of the tripeptide H-Gly-Gly-Leu-OH to the binding site. The results are consistent with the assumption that TolC acts as an outer membrane channel for peptides. ..
  6. Popova A, Hincha D. Effects of cholesterol on dry bilayers: interactions between phosphatidylcholine unsaturation and glycolipid or free sugar. Biophys J. 2007;93:1204-14 pubmed
    ..The data indicate a complex balance of interactions between the different components in the dry state and a strong influence of fatty acid unsaturation on the interactions of the diacyl lipids with both cholesterol and galactose. ..
  7. Hauss T, Dante S, Haines T, Dencher N. Localization of coenzyme Q10 in the center of a deuterated lipid membrane by neutron diffraction. Biochim Biophys Acta. 2005;1710:57-62 pubmed
    ..Thus ubiquinone, in addition to its free radical scavenging and its well-known role in oxidative phosphorylation as a carrier of electrons and protons, might also act as an inhibitor of transmembrane proton leaks. ..
  8. Eckert G, Wood W, Muller W. Lipid membranes and beta-amyloid: a harmful connection. Curr Protein Pept Sci. 2010;11:319-25 pubmed
    ..Perturbation of membranes, binding to lipids and alteration of cellular calcium signaling by Abeta have been reported by several studies and these topics are examined in this review. ..
  9. Thess A, Hutschenreiter S, Hofmann M, Tampe R, Baumeister W, Guckenberger R. Specific orientation and two-dimensional crystallization of the proteasome at metal-chelating lipid interfaces. J Biol Chem. 2002;277:36321-8 pubmed
  10. Kubelt J, Menon A, Muller P, Herrmann A. Transbilayer movement of fluorescent phospholipid analogues in the cytoplasmic membrane of Escherichia coli. Biochemistry. 2002;41:5605-12 pubmed
    ..No flip-flop was detected in protein-free liposomes, but in IIMV-derived proteoliposomes flip-flop of M-C6-NBD-PE occurred similarly to IIMV and could be largely eliminated by proteinase K treatment. ..
  11. Martos A, Jimenez M, Rivas G, Schwille P. Towards a bottom-up reconstitution of bacterial cell division. Trends Cell Biol. 2012;22:634-43 pubmed publisher
  12. Fertig N, Meyer C, Blick R, Trautmann C, Behrends J. Microstructured glass chip for ion-channel electrophysiology. Phys Rev E Stat Nonlin Soft Matter Phys. 2001;64:040901 pubmed
    ..The function of the device is demonstrated by recordings of single channel currents mediated by the model ion channel gramicidin A in lipid bilayers spanning the micromachined aperture. ..
  13. Zaitseva E, Brown M, Vogel R. Sequential rearrangement of interhelical networks upon rhodopsin activation in membranes: the Meta II(a) conformational substate. J Am Chem Soc. 2010;132:4815-21 pubmed publisher
  14. Andrä J, Goldmann T, Ernst C, Peschel A, Gutsmann T. Multiple peptide resistance factor (MprF)-mediated Resistance of Staphylococcus aureus against antimicrobial peptides coincides with a modulated peptide interaction with artificial membranes comprising lysyl-phosphatidylglycerol. J Biol Chem. 2011;286:18692-700 pubmed publisher
    ..Altogether, our data support and underline the significance of lysyl-PG for S. aureus resistance to AMPs. ..
  15. Ludolphs M, Schneeberger D, Soykan T, Schäfer J, Papadopoulos T, Brose N, et al. Specificity of Collybistin-Phosphoinositide Interactions: IMPACT OF THE INDIVIDUAL PROTEIN DOMAINS. J Biol Chem. 2016;291:244-54 pubmed publisher
    ..This type of membrane tethering under the control of the release of the SH3 domain of CB is essential for regulating gephyrin clustering. ..
  16. Hagn F, Nasr M, Wagner G. Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR. Nat Protoc. 2018;13:79-98 pubmed publisher
    ..Although the focus of this protocol is on protein NMR, these nanodiscs can also be used for (cryo-) electron microscopy (EM) and small-angle X-ray and neutron-scattering studies...
  17. Bosio A, Binczek E, Stoffel W. Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis. Proc Natl Acad Sci U S A. 1996;93:13280-5 pubmed
    ..GalC and sGalC are essential for the unperturbed lipid bilayer of the myelin membrane of CNS and PNS. The severe dysmyelinosis leads to death of the cgt-/- mouse at the end of the myelination period. ..
  18. Arouri A, Dathe M, Blume A. Peptide induced demixing in PG/PE lipid mixtures: a mechanism for the specificity of antimicrobial peptides towards bacterial membranes?. Biochim Biophys Acta. 2009;1788:650-9 pubmed publisher
  19. Shanmugavadivu B, Apell H, Meins T, Zeth K, Kleinschmidt J. Correct folding of the beta-barrel of the human membrane protein VDAC requires a lipid bilayer. J Mol Biol. 2007;368:66-78 pubmed
  20. Wollny G, Brundermann E, Arsov Z, Quaroni L, Havenith M. Nanoscale depth resolution in scanning near-field infrared microscopy. Opt Express. 2008;16:7453-9 pubmed
    ..Contrast evaluation as a function of layer thickness provides the near-field depth resolution. ..
  21. Schumann U, Wanner G, Veenhuis M, Schmid M, Gietl C. AthPEX10, a nuclear gene essential for peroxisome and storage organelle formation during Arabidopsis embryogenesis. Proc Natl Acad Sci U S A. 2003;100:9626-31 pubmed
    ..The ultrastructural knockout phenotype of AthPEX10p suggests that this protein in Arabidopsis is essential for peroxisome, oleosome, and protein transport vesicle formation. ..
  22. Costa Riu N, Maier E, Burkovski A, Kr mer R, Lottspeich F, Benz R. Identification of an anion-specific channel in the cell wall of the Gram-positive bacterium Corynebacterium glutamicum. Mol Microbiol. 2003;50:1295-308 pubmed
    ..The gene products PorBCglut and PorCCglut represent obviously other permeability pathways for the transport of hydrophilic compounds through the cell wall of C. glutamicum...
  23. Olausson B, Grossfield A, Pitman M, Brown M, Feller S, Vogel A. Molecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes. J Am Chem Soc. 2012;134:4324-31 pubmed publisher
  24. Kleinschmidt J. Folding kinetics of the outer membrane proteins OmpA and FomA into phospholipid bilayers. Chem Phys Lipids. 2006;141:30-47 pubmed
    ..A study on FomA folding into lipid bilayers indicated the presence of parallel folding pathways for OMPs with larger transmembrane beta-barrels. ..
  25. Güldenhaupt J, Adiguzel Y, Kuhlmann J, Waldmann H, Kötting C, Gerwert K. Secondary structure of lipidated Ras bound to a lipid bilayer. FEBS J. 2008;275:5910-8 pubmed publisher
    ..The novel attenuated total reflectance approach opens the way for detailed studies of the interaction network of the membrane-bound Ras protein. ..
  26. Wiebalck S, Kozuch J, Forbrig E, Tzschucke C, Jeuken L, Hildebrandt P. Monitoring the Transmembrane Proton Gradient Generated by Cytochrome bo3 in Tethered Bilayer Lipid Membranes Using SEIRA Spectroscopy. J Phys Chem B. 2016;120:2249-56 pubmed publisher
    ..8 pH units. This study demonstrates the high potential of tBLMs and the SEIRA spectroscopic approach to study bioenergetic processes. ..
  27. Salgado J, Grage S, Kondejewski L, Hodges R, McElhaney R, Ulrich A. Membrane-bound structure and alignment of the antimicrobial beta-sheet peptide gramicidin S derived from angular and distance constraints by solid state 19F-NMR. J Biomol NMR. 2001;21:191-208 pubmed
    ..This study demonstrates the potential of the 19F nucleus to describe suitably labelled polypeptides in membranes, requiring only little material and short NMR acquisition times. ..
  28. Pieper T, Markova S, Kinjo M, Suter D. Effect of cholesterol on diffusion in surfactant bilayers. J Chem Phys. 2007;127:165102 pubmed
    ..We find that a reduction of the diffusion coefficient is already detectable at a molar ratio of 8 mol % cholesterol. ..
  29. Baaken G, Sondermann M, Schlemmer C, Rühe J, Behrends J. Planar microelectrode-cavity array for high-resolution and parallel electrical recording of membrane ionic currents. Lab Chip. 2008;8:938-44 pubmed publisher
    ..Resolution of voltage-dependent current transitions of alamethicin channels as well as polyethylene-glycol-induced blocking events of alpha-hemolysin nanopores on the submillisecond time scale is demonstrated using this device. ..
  30. Sobhanifar S, Schneider B, Lohr F, Gottstein D, Ikeya T, Mlynarczyk K, et al. Structural investigation of the C-terminal catalytic fragment of presenilin 1. Proc Natl Acad Sci U S A. 2010;107:9644-9 pubmed publisher
  31. Wadhwani P, Strandberg E, Heidenreich N, Bürck J, Fanghänel S, Ulrich A. Self-assembly of flexible ?-strands into immobile amyloid-like ?-sheets in membranes as revealed by solid-state 19F NMR. J Am Chem Soc. 2012;134:6512-5 pubmed publisher
    ..It promises to be a valuable approach for studying membrane-induced amyloid formation of many other, clinically relevant peptide systems. ..
  32. Hutschenreiter S, Tinazli A, Model K, Tampe R. Two-substrate association with the 20S proteasome at single-molecule level. EMBO J. 2004;23:2488-97 pubmed
    ..Thus, the two-stroke engine offers the advantage of speeding up degradation without enhancing complexity. ..
  33. Smith A, Lorz B, Seifert U, Sackmann E. Antagonist-induced deadhesion of specifically adhered vesicles. Biophys J. 2006;90:1064-80 pubmed
    ..The work presented herein also provides a new method for the determination of the receptor binding affinity of either the surface-embedded ligands or the competing antagonist molecules. ..
  34. Popova A, Hincha D. Intermolecular interactions in dry and rehydrated pure and mixed bilayers of phosphatidylcholine and digalactosyldiacylglycerol: a Fourier transform infrared spectroscopy study. Biophys J. 2003;85:1682-90 pubmed
    ..We present evidence that these interactions influence the mixing behavior in phosphatidylcholine/DGDG membranes and also the phase behavior of both EPC/DGDG and pure DGDG membranes in the dry state. ..
  35. Elfrink K, Nagel Steger L, Riesner D. Interaction of the cellular prion protein with raft-like lipid membranes. Biol Chem. 2007;388:79-89 pubmed
    ..This corresponds to a free energy of the insertion reaction of -48 kJ/mol. Consequences for the conversion of PrP(C) to PrP(Sc) are discussed. ..
  36. Krack M, Hohenberg H, Kornowski A, Lindner P, Weller H, Forster S. Nanoparticle-loaded magnetophoretic vesicles. J Am Chem Soc. 2008;130:7315-20 pubmed publisher
    ..The nanoparticle uptake of the vesicles is sufficiently high to become magnetophoretic in external magnetic fields as shown by video microscopy. ..
  37. Bárcena Uribarri I, Thein M, Maier E, Bonde M, Bergstrom S, Benz R. Use of nonelectrolytes reveals the channel size and oligomeric constitution of the Borrelia burgdorferi P66 porin. PLoS ONE. 2013;8:e78272 pubmed publisher
    ..Two dimension SDS PAGE revealed that P66 is the only polypeptide in the complex. ..
  38. Fertig N, George M, Klau M, Meyer C, Tilke A, Sobotta C, et al. Microstructured apertures in planar glass substrates for ion channel research. Receptors Channels. 2003;9:29-40 pubmed
    ..An additional attractive application that is greatly facilitated by the combination of planar geometry with the optical neutrality of the substrate is single-molecule fluorescence recording with simultaneous single-channel measurements. ..
  39. Limozin L, Bärmann M, Sackmann E. On the organization of self-assembled actin networks in giant vesicles. Eur Phys J E Soft Matter. 2003;10:319-30 pubmed
    ..The fuzzy-cortex formation is interpreted as a consequence of the reduction of the bending energy if the actin filaments accumulate close to the vesicle wall. ..
  40. Kirchhoff H, Borinski M, Lenhert S, Chi L, Büchel C. Transversal and lateral exciton energy transfer in grana thylakoids of spinach. Biochemistry. 2004;43:14508-16 pubmed
    ..Because the connectivity is constant over all degrees of destacking employed, we conclude that the energy transfer in granas is mainly lateral. ..
  41. Palusinska Szysz M, Zdybicka Barabas A, Reszczynska E, Luchowski R, Kania M, Gisch N, et al. The lipid composition of Legionella dumoffii membrane modulates the interaction with Galleria mellonella apolipophorin III. Biochim Biophys Acta. 2016;1861:617-29 pubmed publisher
    ..e. characterized by an increased PC/PE ratio. This could explain, at least in part, the higher susceptibility of choline-cultured L. dumoffii to G. mellonella apoLp-III. ..
  42. Hoernke M, Schwieger C, Kerth A, Blume A. Binding of cationic pentapeptides with modified side chain lengths to negatively charged lipid membranes: Complex interplay of electrostatic and hydrophobic interactions. Biochim Biophys Acta. 2012;1818:1663-72 pubmed
  43. Endress E, Heller H, Casalta H, Brown M, Bayerl T. Anisotropic motion and molecular dynamics of cholesterol, lanosterol, and ergosterol in lecithin bilayers studied by quasi-elastic neutron scattering. Biochemistry. 2002;41:13078-86 pubmed
    ..The results provide an example of how slight structural alterations of sterols can affect their molecular dynamics in bilayers, which in turn may be relevant to the membrane micromechanical properties. ..
  44. Grziwa B, Grimm M, Masters C, Beyreuther K, Hartmann T, Lichtenthaler S. The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted. J Biol Chem. 2003;278:6803-8 pubmed
    ..Moreover, the center of the TMD is positioned at the gamma-cleavage site at residue 42. Our data are consistent with a model in which gamma-secretase is a membrane protein that cleaves at the center of the membrane. ..
  45. Bannwarth M, Schulz G. Asymmetric conductivity of engineered porins. Protein Eng. 2002;15:799-804 pubmed
    ..The results encourage attempts to improve the inserts in order to eventually reach diode characteristics...
  46. John K, Schreiber S, Kubelt J, Herrmann A, Muller P. Transbilayer movement of phospholipids at the main phase transition of lipid membranes: implications for rapid flip-flop in biological membranes. Biophys J. 2002;83:3315-23 pubmed
    ..Molecular packing defects at the phase transition are assumed to be responsible for the rapid transbilayer movement. The relevance of those defects for understanding of the activity of flippases is discussed. ..
  47. Popova A, Hincha D. Specific interactions of tryptophan with phosphatidylcholine and digalactosyldiacylglycerol in pure and mixed bilayers in the dry and hydrated state. Chem Phys Lipids. 2004;132:171-84 pubmed
    ..In the rehydrated state, the H-bonding interactions between amino acids and lipids are mostly replaced by interactions between water and lipids, while the hydrophobic interactions between lipids and tryptophan mostly persist. ..
  48. Reiss K, Cornelsen I, Husmann M, Gimpl G, Bhakdi S. Unsaturated fatty acids drive disintegrin and metalloproteinase (ADAM)-dependent cell adhesion, proliferation, and migration by modulating membrane fluidity. J Biol Chem. 2011;286:26931-42 pubmed publisher
    ..We propose that FFA represent critical regulators of ADAM function that may assume relevance in many biological settings through their influence on mobility of enzyme and substrate in lipid bilayers. ..
  49. Eing A, Janshoff A, Galla H, Block C, Steinem C. Quantification of the Raf-C1 interaction with solid-supported bilayers. Chembiochem. 2002;3:190-7 pubmed
    ..We hypothesize that PS-enriched domains are initial binding sites with high affinity for Raf-C1, but that lateral interactions may account for protein domain growth. ..
  50. Wolkers W, Oldenhof H, Glasmacher B. Dehydrating phospholipid vesicles measured in real-time using ATR Fourier transform infrared spectroscopy. Cryobiology. 2010;61:108-14 pubmed publisher
    ..We conclude that water entrapment rather than water replacement explains the effect of trehalose on lipid phase behavior of phosphatidylcholine lipid bilayers during the initial phase of drying. ..
  51. Lee J, Klusener B, Tsiamis G, Stevens C, Neyt C, Tampakaki A, et al. HrpZ(Psph) from the plant pathogen Pseudomonas syringae pv. phaseolicola binds to lipid bilayers and forms an ion-conducting pore in vitro. Proc Natl Acad Sci U S A. 2001;98:289-94 pubmed publisher
    ..Such pore-forming activity may allow nutrient release and/or delivery of virulence factors during bacterial colonization of host plants...
  52. Wieser T, Deschauer M, Olek K, Hermann T, Zierz S. Carnitine palmitoyltransferase II deficiency: molecular and biochemical analysis of 32 patients. Neurology. 2003;60:1351-3 pubmed
    ..Using modeling techniques, a structure could be identified anchoring the protein in the membrane. Only one of the five mutations (Y479F) is located within this region. ..
  53. Paschen S, Waizenegger T, Stan T, Preuss M, Cyrklaff M, Hell K, et al. Evolutionary conservation of biogenesis of beta-barrel membrane proteins. Nature. 2003;426:862-6 pubmed
    ..We present evidence that important elements of the topogenesis of beta-barrel membrane proteins have been conserved during the evolution of mitochondria from endosymbiotic bacterial ancestors. ..
  54. Horn C, Steinem C. Photocurrents generated by bacteriorhodopsin adsorbed on nano-black lipid membranes. Biophys J. 2005;89:1046-54 pubmed
    ..By adding the proton ionophore carbonyl cyanide-m-chlorophenylhydrazone the conductivity of the nano-BLMs increases, resulting in a higher stationary current, which proves that proton conductance occurs across the nano-BLMs...
  55. Hemmler R, Becker T, Schleiff E, Bölter B, Stahl T, Soll J, et al. Molecular properties of Oep21, an ATP-regulated anion-selective solute channel from the outer chloroplast membrane. J Biol Chem. 2006;281:12020-9 pubmed
    ..Deletion of a C-terminal putative FX4K binding motif in Oep21 decreased the capability of the channel to tune its ion selectivity by about 50%, whereas current block remained unchanged...
  56. Hoffmann C, Leis A, Niederweis M, Plitzko J, Engelhardt H. Disclosure of the mycobacterial outer membrane: cryo-electron tomography and vitreous sections reveal the lipid bilayer structure. Proc Natl Acad Sci U S A. 2008;105:3963-7 pubmed publisher
    ..These results are crucial for the investigation and understanding of transport processes across the mycobacterial cell wall, and they are of particular medical relevance in the case of pathogenic mycobacteria. ..
  57. Hammer M, Brauser A, Olak C, Brezesinski G, Goldmann T, Gutsmann T, et al. Lipopolysaccharide interaction is decisive for the activity of the antimicrobial peptide NK-2 against Escherichia coli and Proteus mirabilis. Biochem J. 2010;427:477-88 pubmed publisher
    ..Instead, differences in activity originated from the LPS-binding step, which could be demonstrated by NK-2 attachment to intact bacteria, and to solid-supported LPS bilayers on a surface acoustic wave biosensor...
  58. Buchsteiner A, Hauss T, Dante S, Dencher N. Alzheimer's disease amyloid-beta peptide analogue alters the ps-dynamics of phospholipid membranes. Biochim Biophys Acta. 2010;1798:1969-76 pubmed publisher
    ..The amyloid-beta (25-35) peptide induced membrane alteration even at only 3mol% might be involved in the pathology of Alzheimer's disease as well as be a clue in early diagnosis and therapy. ..
  59. Neumann J, Hennig M, Wixforth A, Manus S, Rädler J, Schneider M. Transport, separation, and accumulation of proteins on supported lipid bilayers. Nano Lett. 2010;10:2903-8 pubmed publisher
    ..The modular planar setup has the potential of integrating other lab-on-a-chip tools, for monitoring the membrane-protein integrity or adding microfluidic features for blood screening or DNA analysis. ..
  60. Weizenmann N, Huster D, Scheidt H. Interaction of local anesthetics with lipid bilayers investigated by ¹H MAS NMR spectroscopy. Biochim Biophys Acta. 2012;1818:3010-8 pubmed publisher
    ..In contrast the side chains of lidocaine and procaine are oriented towards the aqueous phase...
  61. Weimbs T, Stoffel W. Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide-bonded, and fatty acid thioester-linked cysteine residues and implications for the membrane topology of PLP. Biochemistry. 1992;31:12289-96 pubmed
    ..The structural data not only demand the revision of our concept of the membrane topology of PLP but will also promote more sophisticated studies on the mechanism of myelination and new functions of PLP. ..
  62. Brdiczka D, Kaldis P, Wallimann T. In vitro complex formation between the octamer of mitochondrial creatine kinase and porin. J Biol Chem. 1994;269:27640-4 pubmed
    ..Thus, besides a specific structural interaction, a defined physiological function is assumed of the mitochondrial creatine kinase-porin complexes that are discussed here. ..
  63. Heim M, Cevc G, Guckenberger R, Knapp H, Wiegräbe W. Lateral electrical conductivity of mica-supported lipid bilayer membranes measured by scanning tunneling microscopy. Biophys J. 1995;69:489-97 pubmed
    ..The fact that similar observations are also made for other hydrophilic substrates supports the conclusion that lateral conductivity via surface-adsorbed water is a rather general phenomenon. ..
  64. Frenkel C, Gerhard A, Wartenberg H, Rehberg B, Urban B. No evidence for specific opioid effects on batrachotoxin-modified sodium channels from human brain synaptosomes. Neurosci Lett. 1997;229:41-4 pubmed
    ..Thus, human CNS sodium channels are probably not a main target site for the clinical effects of alfentanil but they provide a model system to estimate the proportion of the lipophilic interactions contributing to its overall effect. ..
  65. Pautsch A, Schulz G. Structure of the outer membrane protein A transmembrane domain. Nat Struct Biol. 1998;5:1013-7 pubmed
    ..The structure constitutes a beta-barrel membrane anchor that appears to be the outer membrane equivalent of the single-chain alpha-helix anchor of the inner membrane. ..
  66. Andersen C, Rak B, Benz R. The gene bglH present in the bgl operon of Escherichia coli, responsible for uptake and fermentation of beta-glucosides encodes for a carbohydrate-specific outer membrane porin. Mol Microbiol. 1999;31:499-510 pubmed
    ..The kinetics of cellopentaose binding to BglH was investigated using the carbohydrate-induced current noise and was compared with that of cellopentaose binding to LamB (maltoporin) and ScrY (sucroseporin). ..
  67. Engelk M, Bojarski P, Bloss R, Diehl H. Tamoxifen perturbs lipid bilayer order and permeability: comparison of DSC, fluorescence anisotropy, laurdan generalized polarization and carboxyfluorescein leakage studies. Biophys Chem. 2001;90:157-73 pubmed
    ..From membrane permeability measurements, we conclude that the tamoxifen-induced release of entrapped carboxyfluorescein (CF) results from a permanent bilayer disruption and the formation of transient holes in the lipid bilayer. ..
  68. Hagge S, de Cock H, Gutsmann T, Beckers F, Seydel U, Wiese A. Pore formation and function of phosphoporin PhoE of Escherichia coli are determined by the core sugar moiety of lipopolysaccharide. J Biol Chem. 2002;277:34247-53 pubmed
    ..Furthermore, we found that the voltage gating of the porin channels is strongly dependent on the composition of the lipid matrix. ..
  69. Braun M, Killmann H, Maier E, Benz R, Braun V. Diffusion through channel derivatives of the Escherichia coli FhuA transport protein. Eur J Biochem. 2002;269:4948-59 pubmed
    ..It is concluded that FhuADelta5-160 Delta335-355 assumes a conformation that is incompatible with any of the FhuA functions. ..
  70. Burzik C, Kaim G, Dimroth P, Bamberg E, Fendler K. Charge displacements during ATP-hydrolysis and synthesis of the Na+-transporting FoF1-ATPase of Ilyobacter tartaricus. Biophys J. 2003;85:2044-54 pubmed
    ..For ATP synthesis the rate constant is 50-70 s(-1)...
  71. Bruhn H, Winkelmann J, Andersen C, Andrä J, Leippe M. Dissection of the mechanisms of cytolytic and antibacterial activity of lysenin, a defence protein of the annelid Eisenia fetida. Dev Comp Immunol. 2006;30:597-606 pubmed
    ..Accordingly, lysenin appears to display sphingomyelin-dependent and sphingomyelin-independent activities to kill various foreign intruders of the earthworm's coelomic cavity...
  72. Löw C, Weininger U, Lee H, Schweimer K, Neundorf I, Beck Sickinger A, et al. Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers. Biophys J. 2008;95:4315-23 pubmed publisher
    ..These findings support models for membrane curving by BAR domains in which helix-0 increases the binding affinity to the membrane and enhances curvature generation. ..
  73. Ciobanasu C, Harms E, Tunnemann G, Cardoso M, Kubitscheck U. Cell-penetrating HIV1 TAT peptides float on model lipid bilayers. Biochemistry. 2009;48:4728-37 pubmed publisher
    ..The diffusion constants were not dependent on the TAT concentration ranging from 150 pM to 2 microM, indicating that the peptides were not aggregated on the membrane and not forming any "carpet". ..
  74. Behr J, Vogel R. Mechanisms of hop inhibition: hop ionophores. J Agric Food Chem. 2009;57:6074-81 pubmed publisher
    ..brevis strains, which can cope with unusually low intracellular manganese levels, can survive hop stress. Accordingly, cross-resistance to single proton ionophores or H(+)/Mn(2+) exchangers was not detectable and cannot be expected. ..
  75. Patel G, Behrens Kneip S, Holst O, Kleinschmidt J. The periplasmic chaperone Skp facilitates targeting, insertion, and folding of OmpA into lipid membranes with a negative membrane surface potential. Biochemistry. 2009;48:10235-45 pubmed publisher
    ..The faster phase dominated when the experimental conditions favored the less compact form of aqueous OmpA...
  76. Saleem M, Galla H. Surface view of the lateral organization of lipids and proteins in lung surfactant model systems-a ToF-SIMS approach. Biochim Biophys Acta. 2010;1798:730-40 pubmed publisher
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