Experts and Doctors on l type calcium channels in Israel
Topic: l type calcium channels
Kanevsky N, Dascal N. Regulation of maximal open probability is a separable function of Ca(v)beta subunit in L-type Ca2+ channel, dependent on NH2 terminus of alpha1C (Ca(v)1.2alpha). J Gen Physiol. 2006;128:15-36 pubmed
..We conclude that regulation of P(o,max) is a discrete, separable function of Ca(v)beta. In Ca(v)1.2, this action of Ca(v)beta depends on NT of alpha1C and is alpha1C isoform specific. ..
Priel T, Hershfinkel M. Zinc influx and physiological consequences in the beta-insulinoma cell line, Min6. Biochem Biophys Res Commun. 2006;346:205-12 pubmed
..Our results demonstrate homeostatic crosstalk between the plasma membrane and intracellular zinc transporters and suggest that attenuating zinc influx may enhance beta-cell survival. ..
Blumenstein Y, Kanevsky N, Sahar G, Barzilai R, Ivanina T, Dascal N. A novel long N-terminal isoform of human L-type Ca2+ channel is up-regulated by protein kinase C. J Biol Chem. 2002;277:3419-23 pubmed
..The long-NT isoform may be the Ca(2+) channel enhanced by PKC-activating transmitters in human tissues. ..
Opatowsky Y, Chomsky Hecht O, Kang M, Campbell K, Hirsch J. The voltage-dependent calcium channel beta subunit contains two stable interacting domains. J Biol Chem. 2003;278:52323-32 pubmed
..Domain II is responsible for this binding, but domain I enhances it. ..
Shapiro H, Shachar S, Sekler I, Hershfinkel M, Walker M. Role of GPR40 in fatty acid action on the beta cell line INS-1E. Biochem Biophys Res Commun. 2005;335:97-104 pubmed
..Taken together, the data indicate that GPR40 mediates the increase in [Ca2+]i and insulin secretion through the Galphaq-PLC pathway, resulting in release of Ca2+ from the ER and leading to up-regulation of Ca2+ influx via LTCC. ..
Perets T, Blumenstein Y, Shistik E, Lotan I, Dascal N. A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunit. FEBS Lett. 1996;384:189-92 pubmed
..This effect was independent of the presence of the beta subunit. Phosphorylation of serine 1928 of alpha 1C may mediate the modulatory effect of PKA on the cardiac voltage-dependent ca2+ channel. ..
Beharier O, Etzion Y, Katz A, Friedman H, Tenbosh N, Zacharish S, et al
. Crosstalk between L-type calcium channels and ZnT-1, a new player in rate-dependent cardiac electrical remodeling. Cell Calcium. 2007;42:71-82 pubmed
Kaisman Elbaz T, Sekler I, Fishman D, Karol N, Forberg M, Kahn N, et al
. Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules. J Cell Physiol. 2009;220:222-9 pubmed publisher
..Taken together, our results indicate that Zn(2+) and Cd(2+) influx induce expression and secretion of clusterin, thereby linking metal homeostasis and germ cell fate...
Levy S, Beharier O, Etzion Y, Mor M, Buzaglo L, Shaltiel L, et al
. Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels. J Biol Chem. 2009;284:32434-43 pubmed publisher