Experts and Doctors on kinetics in United States


Locale: United States
Topic: kinetics

Top Publications

  1. Mejillano M, Jahansouz H, Matsunaga T, Kenyon G, Himes R. Formation and utilization of formyl phosphate by N10-formyltetrahydrofolate synthetase: evidence for formyl phosphate as an intermediate in the reaction. Biochemistry. 1989;28:5136-45 pubmed
    ..The absence of scrambling of the 18O label as observed by 31P NMR suggests that the central complex may impose restraints to limit free rotation of the P beta oxygens of the product ADP. ..
  2. Beatty W, Byrne G, Morrison R. Morphologic and antigenic characterization of interferon gamma-mediated persistent Chlamydia trachomatis infection in vitro. Proc Natl Acad Sci U S A. 1993;90:3998-4002 pubmed
  3. Jean F, Stella K, Thomas L, Liu G, Xiang Y, Reason A, et al. alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent. Proc Natl Acad Sci U S A. 1998;95:7293-8 pubmed
    ..Finally, we propose a structural model of the alpha1-PDX-reactive site loop that explains the high degree of enzyme selectivity of this serpin and which can be used to generate small molecule furin inhibitors. ..
  4. Schmidt M, Ding H, Ramamurthy V, Mukerji I, Oliver D. Nucleotide binding activity of SecA homodimer is conformationally regulated by temperature and altered by prlD and azi mutations. J Biol Chem. 2000;275:15440-8 pubmed
    ..These results provide the first direct evidence for conformational regulation of the SecA-dependent nucleotide cycle, its alteration in azi and prlD mutants, and its relevance to in vivo protein export. ..
  5. Zhou M, Kimelberg H. Freshly isolated astrocytes from rat hippocampus show two distinct current patterns and different [K(+)](o) uptake capabilities. J Neurophysiol. 2000;84:2746-57 pubmed
    ..ORAs show abundant outward potassium currents with more depolarized RMP. Thus VRAs and ORAs may cooperate in vivo for uptake and release of K(+), respectively...
  6. Ason B, Handayani R, Williams C, Bertram J, Hingorani M, O Donnell M, et al. Mechanism of loading the Escherichia coli DNA polymerase III beta sliding clamp on DNA. Bona fide primer/templates preferentially trigger the gamma complex to hydrolyze ATP and load the clamp. J Biol Chem. 2003;278:10033-40 pubmed
  7. Umesh A, Cohen B, Ross L, Gill S. Functional characterization of a glutamate/aspartate transporter from the mosquito Aedes aegypti. J Exp Biol. 2003;206:2241-55 pubmed
    ..Together, the work presented here provides a thorough examination of the role played by glutamate transport in Ae. aegypti...
  8. Lee A, Conney A, Zhu B. Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol. Cancer Res. 2003;63:6532-6 pubmed
  9. Davis J, Rall J, Alionte C, Tikunova S. Mutations of hydrophobic residues in the N-terminal domain of troponin C affect calcium binding and exchange with the troponin C-troponin I96-148 complex and muscle force production. J Biol Chem. 2004;279:17348-60 pubmed
    ..In conclusion, elucidating the determinants of calcium binding and exchange with troponin C in the presence of troponin I provides a deeper understanding of how troponin C controls signal transduction. ..

More Information

Publications729 found, 100 shown here

  1. Horio T, Oakley B. The role of microtubules in rapid hyphal tip growth of Aspergillus nidulans. Mol Biol Cell. 2005;16:918-26 pubmed
    ..These data also reveal that A. nidulans exhibits a remarkable spatial regulation of microtubule disassembly within hyphal tip cells...
  2. Zhang S, Zhou L, Nemeria N, Yan Y, Zhang Z, Zou Y, et al. Evidence for dramatic acceleration of a C-H bond ionization rate in thiamin diphosphate enzymes by the protein environment. Biochemistry. 2005;44:2237-43 pubmed
    ..This finding is likely a general feature of thiamin diphosphate enzymes. ..
  3. Lin D, Lee H, Liu Q, Perry G, Smith M, Sayre L. 4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal. Chem Res Toxicol. 2005;18:1219-31 pubmed
    ..The greater neurotoxicity of ONE could reflect in part the different reactivity characteristics of ONE as compared to HNE...
  4. Ravyn V, Bostwick J. Functional coupling of the Galpha(olf) variant XLGalpha(olf) with the human adenosine A2A receptor. J Recept Signal Transduct Res. 2006;26:241-58 pubmed
    ..This pharmacology is consistent with the literature for A2AR and suggests that Sf9 cells co-expressing A2AR, beta1, gamma2, and XLGalphaolf could serve as a heterologous expression system for A2AR drug screening. ..
  5. McAnelly M, Zakon H. Androgen modulates the kinetics of the delayed rectifying K+ current in the electric organ of a weakly electric fish. Dev Neurobiol. 2007;67:1589-97 pubmed
    ..Thus, androgens coregulate the time-varying kinetics of two distinct ion currents in the EO to shape a sexually dimorphic communication signal...
  6. Spruill L, Lowry A, Stroud R, Squires C, Mains I, Flack E, et al. Membrane-type-1 matrix metalloproteinase transcription and translation in myocardial fibroblasts from patients with normal left ventricular function and from patients with cardiomyopathy. Am J Physiol Cell Physiol. 2007;293:C1362-73 pubmed
    ..These phenotypic changes in DCM fibroblasts may provide the basis for developing cell specific pharmacological targets for control of MT1-MMP expression. ..
  7. Benkovic S, Hammes G, Hammes Schiffer S. Free-energy landscape of enzyme catalysis. Biochemistry. 2008;47:3317-21 pubmed publisher
    ..Experimental and theoretical evidence is presented to support this concept. ..
  8. Liu Y, Annis D, Mosher D. Interactions among the epidermal growth factor-like modules of thrombospondin-1. J Biol Chem. 2009;284:22206-12 pubmed publisher
    ..7, which recognize epitopes in E2, bound to E12, E23, or E123 with greater affinity than to E2 alone. These results indicate that interactions among the modules of E123 influence the tertiary structure and calcium binding of E2. ..
  9. Mickelson D, Sproat L, Dean R, Sobecks R, Rybicki L, Kalaycio M, et al. Comparison of donor chimerism following myeloablative and nonmyeloablative allogeneic hematopoietic SCT. Bone Marrow Transplant. 2011;46:84-9 pubmed publisher
    ..Donor T-cell chimerism of ? 90% was significantly associated with development of extensive chronic GVHD. The value of routine surveillance of chimerism following any of the preparative regimens used in this study should be reevaluated. ..
  10. Knuckley B, Causey C, Jones J, Bhatia M, Dreyton C, Osborne T, et al. Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3. Biochemistry. 2010;49:4852-63 pubmed publisher
    ..Additionally, the substrate specificity studies provided critical information that aided the identification of PAD3-selective inhibitors. These compounds, denoted F4- and Cl4-amidine, are the most potent PAD3 inhibitors ever described. ..
  11. Liu W, Tang F, Chen J. Designing dynamical output feedback controllers for store-operated Ca²+ entry. Math Biosci. 2010;228:110-8 pubmed publisher
    ..This indicates that the designed feedback controller can reject the disturbance and track the equilibrium. ..
  12. Vunnam N, Flint J, Balbo A, Schuck P, Pedigo S. Dimeric states of neural- and epithelial-cadherins are distinguished by the rate of disassembly. Biochemistry. 2011;50:2951-61 pubmed publisher
    ..These studies provide evidence that the kinetics of dimer disassembly of the extracellular domains may be a major contributor to the morphological dynamics of synapses in vivo. ..
  13. Kim H, Ruszczycky M, Choi S, Liu Y, Liu H. Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A. Nature. 2011;473:109-12 pubmed publisher
    ..In addition, the mode of formation of the complex perhydro-as-indacene moiety in spinosyn A is now fully established. ..
  14. Maier O, Marvin S, Wodrich H, Campbell E, Wiethoff C. Spatiotemporal dynamics of adenovirus membrane rupture and endosomal escape. J Virol. 2012;86:10821-8 pubmed publisher
    ..Thus, Ad5 membrane rupture and endosomal escape appear to be both spatially and temporally distinct events. ..
  15. Doupnik C, Davidson N, Lester H, Kofuji P. RGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels. Proc Natl Acad Sci U S A. 1997;94:10461-6 pubmed
  16. Fukagawa N, Hercules E, Ajami A. L-2-[(13)C]oxothiazolidine-4-carboxylic acid: a probe for precursor mobilization for glutathione synthesis. Am J Physiol Endocrinol Metab. 2000;278:E171-6 pubmed
    ..01). These data support the use of [(13)C]OTZ as a probe to identify individuals who may be at risk for low GSH stores or who have an impaired capacity to synthesize GSH...
  17. Tao L, Cheung A, Nibau C, Wu H. RAC GTPases in tobacco and Arabidopsis mediate auxin-induced formation of proteolytically active nuclear protein bodies that contain AUX/IAA proteins. Plant Cell. 2005;17:2369-83 pubmed
  18. Potter B, Feng L, Parasuram P, Matskevich V, Wilson J, Andrews G, et al. The six zinc fingers of metal-responsive element binding transcription factor-1 form stable and quasi-ordered structures with relatively small differences in zinc affinities. J Biol Chem. 2005;280:28529-40 pubmed
    ..These analyses further suggested that metal sensing by MTF-1 in eukaryotic cells involves multiple zinc fingers and occurs over a 100-fold or less range of accessible Zn(II) concentration. ..
  19. Mihalyo M, Hagymasi A, Slaiby A, Nevius E, Adler A. Dendritic cells program non-immunogenic prostate-specific T cell responses beginning at early stages of prostate tumorigenesis. Prostate. 2007;67:536-46 pubmed
    ..These responses were completely dependent on DC, but not appreciably influenced by Tregs. These results suggest that tolerogenicity is an early and general property of prostate tumors. ..
  20. Zeczycki T, Menefee A, Adina Zada A, Jitrapakdee S, Surinya K, Wallace J, et al. Novel insights into the biotin carboxylase domain reactions of pyruvate carboxylase from Rhizobium etli. Biochemistry. 2011;50:9724-37 pubmed publisher
  21. Zhou G, Chao L, Chao J. Kallistatin: a novel human tissue kallikrein inhibitor. Purification, characterization, and reactive center sequence. J Biol Chem. 1992;267:25873-80 pubmed
    ..The results show that kallistatin is a new member of the serpin superfamily that inhibits human tissue kallikrein. ..
  22. Rush J, van Leyen K, Ouerfelli O, Wolucka B, Waechter C. Transbilayer movement of Glc-P-dolichol and its function as a glucosyl donor: protein-mediated transport of a water-soluble analog into sealed ER vesicles from pig brain. Glycobiology. 1998;8:1195-205 pubmed
  23. Sokal I, Otto Bruc A, Surgucheva I, Verlinde C, Wang C, Baehr W, et al. Conformational changes in guanylyl cyclase-activating protein 1 (GCAP1) and its tryptophan mutants as a function of calcium concentration. J Biol Chem. 1999;274:19829-37 pubmed
    ..Thus, GCAP1 displays thermodynamic and kinetic properties that are compatible with its involvement early in the phototransduction response. ..
  24. Ji H, Jovov B, Fu J, Bishop L, Mebane H, Fuller C, et al. Up-regulation of acid-gated Na(+) channels (ASICs) by cystic fibrosis transmembrane conductance regulator co-expression in Xenopus oocytes. J Biol Chem. 2002;277:8395-405 pubmed
    ..CFTR had no effect on the pH activation of ASIC1a/2a. We conclude that wild type CFTR elevates the acid-gated Na(+) current of ASIC1a/2a in part by altering the kinetics of extracellular Na(+) interaction. ..
  25. Seal R, Shigeri Y, Eliasof S, Leighton B, Amara S. Sulfhydryl modification of V449C in the glutamate transporter EAAT1 abolishes substrate transport but not the substrate-gated anion conductance. Proc Natl Acad Sci U S A. 2001;98:15324-9 pubmed
    ..Moreover, they shed light on some controversial aspects of the EAAT transport cycle, including the kinetics of proton binding and anion conductance activation. ..
  26. Bernt K, Liang M, Ye X, Ni S, Li Z, Ye S, et al. A new type of adenovirus vector that utilizes homologous recombination to achieve tumor-specific replication. J Virol. 2002;76:10994-1002 pubmed
    ..These new Ad.IR-E1A vectors combine elements that allow for tumor-specific transgene expression, efficient viral replication, and spread in liver metastases after systemic vector application. ..
  27. Bransteitter R, Pham P, Scharff M, Goodman M. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A. 2003;100:4102-7 pubmed
  28. Wang P, Tang Y, Tirrell D. Incorporation of trifluoroisoleucine into proteins in vivo. J Am Chem Soc. 2003;125:6900-6 pubmed
    ..3TFI yielded no evidence for in vivo incorporation into recombinant proteins, and no evidence for activation by IleRS in vitro. ..
  29. Kim S, Mollet J, Dong J, Zhang K, Park S, Lord E. Chemocyanin, a small basic protein from the lily stigma, induces pollen tube chemotropism. Proc Natl Acad Sci U S A. 2003;100:16125-30 pubmed
    ..2 Da. Activity of the lily plantacyanin (named chemocyanin) is enhanced in the presence of stigma/stylar cysteine-rich adhesin, previously identified as a pollen tube adhesin in the lily style. ..
  30. Karaveg K, Siriwardena A, Tempel W, Liu Z, Glushka J, Wang B, et al. Mechanism of class 1 (glycosylhydrolase family 47) {alpha}-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control. J Biol Chem. 2005;280:16197-207 pubmed
    ..A novel (3)H(4) conformation is proposed as the exploded transition state. ..
  31. Naught L, Tipton P. Formation and reorientation of glucose 1,6-bisphosphate in the PMM/PGM reaction: transient-state kinetic studies. Biochemistry. 2005;44:6831-6 pubmed
    ..Isotope trapping studies indicate that it partitions to form glucose 1-phosphate or glucose 6-phosphate 14.3 times more frequently than it dissociates from the enzyme. ..
  32. Kim J, Shen R, Olcott M, Rajagopal I, Mathews C. Adenylate kinase of Escherichia coli, a component of the phage T4 dNTP synthetase complex. J Biol Chem. 2005;280:28221-9 pubmed
  33. Walkup A, Appling D. Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase. Arch Biochem Biophys. 2005;442:196-205 pubmed
    ..The Km values for formate and ATP also are lowered when THF polyglutamates are used. The formate Km dropped 79-fold and the ATP Km dropped more than 5-fold when (6R,S)-H4-PteGlu5 was used as the substrate in place of (6R,S)-H4-PteGlu1. ..
  34. Lee H, Johnson K. Fidelity of the human mitochondrial DNA polymerase. J Biol Chem. 2006;281:36236-40 pubmed
    ..We calculate an average fidelity of 1 error in 440,000 nucleotides. ..
  35. Thomson J, Distler A, Bonomo R. Overcoming resistance to beta-lactamase inhibitors: comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at Ambler position 244. Biochemistry. 2007;46:11361-8 pubmed
    ..The R244S mutation affects beta-lactamase inactivators differently, but resistance can be overcome by designing penem inhibitors with strategic chemical properties that improve affinity and impair turnover. ..
  36. Zhan X, Carpenter R, Ellis H. Catalytic importance of the substrate binding order for the FMNH2-dependent alkanesulfonate monooxygenase enzyme. Biochemistry. 2008;47:2221-30 pubmed publisher
    ..These results suggest that an ordered substrate binding mechanism is important in the desulfonation reaction by SsuD with reduced flavin binding first followed by either O2 or octanesulfonate. ..
  37. Rodland K, Bollinger N, Ippolito D, Opresko L, Coffey R, Zangar R, et al. Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells. J Biol Chem. 2008;283:31477-87 pubmed publisher
  38. Larsen C, Bisson W, Dashwood R. Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies. J Med Chem. 2009;52:6543-5 pubmed publisher
    ..Here we report on the ability of tea catechins to suppress MET activation in human colon cancer cells and propose a mechanism by which they might compete for the kinase domain of the MET protein. ..
  39. Martyniuk C, Fang B, Koomen J, Gavin T, Zhang L, Barber D, et al. Molecular mechanism of glyceraldehyde-3-phosphate dehydrogenase inactivation by ?,?-unsaturated carbonyl derivatives. Chem Res Toxicol. 2011;24:2302-11 pubmed publisher
    ..These specialized cysteine residues are toxicologically relevant molecular targets, because chemical derivatization causes loss of protein function...
  40. PAULK N, Wursthorn K, Haft A, Pelz C, Clarke G, Newell A, et al. In vivo selection of transplanted hepatocytes by pharmacological inhibition of fumarylacetoacetate hydrolase in wild-type mice. Mol Ther. 2012;20:1981-7 pubmed publisher
    ..Compared to controls, recipients treated with the FAH-inhibitor had 20-100-fold increases in liver repopulation. We conclude that pharmacological inhibition of FAH is a promising approach to in vivo selection of hepatocytes. ..
  41. Jeneson J, Westerhoff H, Kushmerick M. A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle. Am J Physiol Cell Physiol. 2000;279:C813-32 pubmed
    ..The functional significance of this result is that, at steady state, ATP free energy consumption cannot outstrip the ATP free energy supply. Therefore, this reduced, three-component muscle ATPase system is inherently homeostatic...
  42. Jain R, Joyce P, Molinete M, Halban P, Gorr S. Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells. Biochem J. 2001;360:645-9 pubmed
    ..These results suggest that the oligomerization of EGFP must be considered when the protein is used as a reporter molecule in the secretory pathway. ..
  43. Shiels J, Tuite J, Nolan S, Baranger A. Investigation of a conserved stacking interaction in target site recognition by the U1A protein. Nucleic Acids Res. 2002;30:550-8 pubmed
  44. Hu Y, Riesland L, Paterson A, Kudlow J. Phosphorylation of mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase increases the enzyme activity. J Biol Chem. 2004;279:29988-93 pubmed
    ..GFAT2 is, therefore, an isoenzyme of GFAT1, but its regulation by cAMP is the opposite, allowing differential regulation of the hexosamine pathway in specialized tissues. ..
  45. Cowan J, Wang X, Guan R, He K, Jiang J, Baumann G, et al. Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage. J Biol Chem. 2005;280:19331-42 pubmed
    ..These data indicate that the GHR is subject to sequential proteolysis by metalloprotease and gamma-secretase activities and may suggest GH-independent roles for the GHR. ..
  46. Jones J, Rawles R, Hannun Y. Identification of a novel phosphatidic acid binding domain in protein phosphatase-1. Biochemistry. 2005;44:13235-45 pubmed
    ..When these results were taken together with the known crystallographic structure of PP1, they identified a novel PA binding region on PP1c gamma that contains a unique loop-strand structural fold responsible for the interaction with PA. ..
  47. Blatnik M, Thorpe S, Baynes J. Succination of proteins by fumarate: mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in diabetes. Ann N Y Acad Sci. 2008;1126:272-5 pubmed publisher
  48. Chen S, Levin M, Sakato M, Zhou Y, Hingorani M. Mechanism of ATP-driven PCNA clamp loading by S. cerevisiae RFC. J Mol Biol. 2009;388:431-42 pubmed publisher
    ..DNA release. This model enables quantitative understanding of the multistep mechanism of a eukaryotic clamp loader and furthermore facilitates comparative analysis of loaders from diverse organisms. ..
  49. Brethauer S, Wyman C. Review: Continuous hydrolysis and fermentation for cellulosic ethanol production. Bioresour Technol. 2010;101:4862-74 pubmed publisher
    ..If sugar generation rates can be increased, the high cell densities in a continuous system could enable higher productivities and yields than in batch fermentations. ..
  50. Hu Z, Perumal S, Yue H, Benkovic S. The human lagging strand DNA polymerase ? holoenzyme is distributive. J Biol Chem. 2012;287:38442-8 pubmed publisher
    ..It is noted that high concentrations of ATP inhibit the holoenzyme DNA synthesis activity, most likely due to its inhibition of the clamp loading process. ..
  51. Kreuzer S, Moon T, Elber R. Catch bond-like kinetics of helix cracking: network analysis by molecular dynamics and milestoning. J Chem Phys. 2013;139:121902 pubmed publisher
    ..It is illustrated that the nature of the reaction networks changes as a function of load, demonstrating that the process is far from one-dimensional. ..
  52. Berger T. Preliminary kinetic evaluation of an immobilized polysaccharide sub-2?m column using a low dispersion supercritical fluid chromatograph. J Chromatogr A. 2017;1510:82-88 pubmed publisher
    ..The differences in Fopt suggests that the solute diffusion coefficients are a strong function of modifier concentration. Several sub-1min separations, including a 7.5s separation, are presented. ..
  53. Cross F. DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae. Mol Cell Biol. 1988;8:4675-84 pubmed
    ..5-fold; thus, DAF1-1 may be a hyperactive or deregulated allele of a nonessential gene involved in G1 size control. Multiple copies of DAF1-1 also greatly reduced the duration of the G1 phase of the cell cycle. ..
  54. Nagiec M, Skrzypek M, Nagiec E, Lester R, Dickson R. The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. J Biol Chem. 1998;273:19437-42 pubmed
    ..cerevisiae. Potential mammalian cDNA homologs of the LCB kinase genes may prove useful in helping to understand the function of sphingosine 1-phosphate in mammals. ..
  55. Tai T, Morita K, Wong D. Role of Egr-1 in cAMP-dependent protein kinase regulation of the phenylethanolamine N-methyltransferase gene. J Neurochem. 2001;76:1851-9 pubmed
    ..These findings demonstrate that the rat PNMT gene promoter can be activated via the cAMP-PKA signal transduction pathway, mediated by the immediate early gene transcription factor, Egr-1. ..
  56. Tong M, Tai H. Synergistic induction of the nicotinamide adenine dinucleotide-linked 15-hydroxyprostaglandin dehydrogenase by an androgen and interleukin-6 or forskolin in human prostate cancer cells. Endocrinology. 2004;145:2141-7 pubmed
    ..These results indicate that the induction of 15-PGDH by DHT, IL-6, and forskolin in LNCaP cells may involve a functional androgen receptor and phosphorylation-dependent multiple signaling pathways. ..
  57. Arthanari H, Wojtuszewski K, Mukerji I, Bolton P. Effects of HU binding on the equilibrium cyclization of mismatched, curved, and normal DNA. Biophys J. 2004;86:1625-31 pubmed
    ..These results have been considered along with those previously obtained to refine a model for the interaction of HU with duplex DNA. ..
  58. Taghon T, David E, Zuniga Pflucker J, Rothenberg E. Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. Genes Dev. 2005;19:965-78 pubmed
  59. Holder D, Keyhani N. Adhesion of the entomopathogenic fungus Beauveria (Cordyceps) bassiana to substrata. Appl Environ Microbiol. 2005;71:5260-6 pubmed
    ..bassiana aerial conidia, blastospores, and submerged conidia could lead to rational design decisions for improving the efficacy and possibly the specificity of entomopathogenic fungi for host targets. ..
  60. Ji Y, Salavaggione O, Wang L, Adjei A, Eckloff B, Wieben E, et al. Human phenylethanolamine N-methyltransferase pharmacogenomics: gene re-sequencing and functional genomics. J Neurochem. 2005;95:1766-76 pubmed
    ..These observations raise the possibility of inherited variation in the ability to form epinephrine from norepinephrine as a result of variant PNMT polymorphisms and haplotypes. ..
  61. Kumar P, Lau C, Mathur M, Wang P, Defea K. Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2. Am J Physiol Cell Physiol. 2007;293:C346-57 pubmed
    ..Together, these data suggest distinct temporal and functional roles for beta-arrestins in PAR-2 signaling, desensitization, and internalization. ..
  62. Park E, Choi S, Muse K, Curry T, Jo M. Response gene to complement 32 expression is induced by the luteinizing hormone (LH) surge and regulated by LH-induced mediators in the rodent ovary. Endocrinology. 2008;149:3025-36 pubmed publisher
    ..In summary, the present study demonstrated the spatial/temporal-specific expression of Rgc32 in the ovary, and provided evidence of LH-initiated and RUNX1-mediated expression of Rgc32 gene in luteinizing granulosa cells. ..
  63. Zhou D, Guo J, Linnenbach A, Booth Genthe C, Grimm S. Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine. Drug Metab Dispos. 2010;38:863-70 pubmed publisher
  64. Scharf M, Kovaleva E, Jadhao S, Campbell J, Buchman G, Boucias D. Functional and translational analyses of a beta-glucosidase gene (glycosyl hydrolase family 1) isolated from the gut of the lower termite Reticulitermes flavipes. Insect Biochem Mol Biol. 2010;40:611-20 pubmed publisher
  65. Cole E, Lakkaraju P, Rampulla D, Morris A, Abelev E, Bocarsly A. Using a one-electron shuttle for the multielectron reduction of CO2 to methanol: kinetic, mechanistic, and structural insights. J Am Chem Soc. 2010;132:11539-51 pubmed publisher
    ..These mechanistic insights should aid the development of more efficient and selective catalysts for the reduction of carbon dioxide to the desired products...
  66. Huang X, Zhao X, Zheng F, Zhan C. Cocaine esterase-cocaine binding process and the free energy profiles by molecular dynamics and potential of mean force simulations. J Phys Chem B. 2012;116:3361-8 pubmed publisher
  67. Cox R, Green T, Purushotham S, Deivanayagam C, Bedwell G, Prevelige P, et al. Structural and functional characterization of the mumps virus phosphoprotein. J Virol. 2013;87:7558-68 pubmed publisher
    ..This is consistent with the observation that both the N- and the C-terminal domains are involved in binding the nucleocapsid. ..
  68. Riegert A, Chantigian D, Thoden J, Tipton P, Holden H. Biochemical Characterization of WbkC, an N-Formyltransferase from Brucella melitensis. Biochemistry. 2017;56:3657-3668 pubmed publisher
    ..These data suggest that this nucleotide binding pocket plays a role in enzyme regulation. Finally, by using an alternative substrate, we demonstrate that WbkC can be utilized to produce a trideoxysugar not found in nature...
  69. Li M, Chung S, Hong S, Goldinger J. Effects of methylguanidine on sodium and organic ion transport. Nephron. 1992;60:349-53 pubmed
    ..These results are not consistent with the hypothesis that MG is a potential uremic toxin that causes the natriuresis and other toxic effects. However, long-term toxic effects of MG on the kidney were not assessed in the present study...
  70. Laine R, Shay N, Kilberg M. Nuclear retention of the induced mRNA following amino acid-dependent transcriptional regulation of mammalian ribosomal proteins L17 and S25. J Biol Chem. 1994;269:9693-7 pubmed
    ..Amino acid refeeding of the cells caused the translocation of the stored nuclear mRNAs to the polysomal fraction. ..
  71. Yuan C, Ault Riché D, Borchardt R. Chemical modification and site-directed mutagenesis of cysteine residues in human placental S-adenosylhomocysteine hydrolase. J Biol Chem. 1996;271:28009-16 pubmed
  72. Tortorella M, Pratta M, Liu R, Abbaszade I, Ross H, Burn T, et al. The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. J Biol Chem. 2000;275:25791-7 pubmed
    ..3) Aggrecanase-1 was not effective in cleaving glycosaminoglycan-free aggrecan. Taken together, these data suggest that the TSP-1 motif of aggrecanase-1 is critical for substrate recognition and cleavage. ..
  73. Wang C, Grishanin R, Earles C, Chang P, Martin T, Chapman E, et al. Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles. Science. 2001;294:1111-5 pubmed
    ..Both synaptotagmin isoforms reduced norepinephrine flux through open fusion pores. Thus, synaptotagmin interacts with fusion pores, possibly by associating with a core complex of membrane proteins and/or lipid...
  74. Papke R, Porter Papke J. Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis. Br J Pharmacol. 2002;137:49-61 pubmed
    ..Since these concentrations are relatively non-desensitizing, the contribution of choline-activated alpha7 receptor current may play a significant role in the regulation of calcium homeostasis in alpha7-expressing neurons. ..
  75. Igo R, Weston D, Ernst N, Panigrahi A, Salavati R, Stuart K. Role of uridylate-specific exoribonuclease activity in Trypanosoma brucei RNA editing. Eukaryot Cell. 2002;1:112-8 pubmed
    ..ExoUase is stereospecific and cannot remove (Rp)alpha-thio-U. The specificity of the exoUase activity thus contributes to the precision of RNA editing. ..
  76. Miranda J. Position-dependent interactions between cysteine residues and the helix dipole. Protein Sci. 2003;12:73-81 pubmed
    ..The nature and magnitude of the helix dipole effect is, therefore, position-dependent. Results from this model system were used to interpret cysteine reactivity in rodent hemoglobins and the thioredoxin family. ..
  77. Bobik T, Rasche M. HPLC assay for methylmalonyl-CoA epimerase. Anal Bioanal Chem. 2003;375:344-9 pubmed
    ..The assay reported here overcomes these difficulties and hence will facilitate studies of MCEs. Such enzymes play important roles in the metabolism of both prokaryotes and higher eukaryotes including humans. ..
  78. Thoden J, Holden H. Molecular structure of galactokinase. J Biol Chem. 2003;278:33305-11 pubmed publisher
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