Experts and Doctors on kinetics in Canada


Locale: Canada
Topic: kinetics

Top Publications

  1. Sridharan G, Gaudreau S, Dalstein L, Huiban C, Lejeune A, Fragata M. Effect of alpha-, beta- and gamma-cyclodextrins on oxygen evolution by the thylakoid membrane. influence of pH and temperature. Z Naturforsch C. 2001;56:792-802 pubmed
  2. Bareich D, Nazi I, Wright G. Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor. Chem Biol. 2003;10:967-73 pubmed
  3. Chen X, Miles R, Snyder C, Truksa M, Zhang J, Shah S, et al. Possible allostery and oligomerization of recombinant plastidial sn-glycerol-3-phosphate acyltransferase. Arch Biochem Biophys. 2014;554:55-64 pubmed publisher
    ..These results could have important regulatory implications when plastidial GPAT is introduced into a cytoplasmic environment where acyl-CoA is the acyl donor supporting cytoplasmic glycerolipid assembly...
  4. King J, Poon K, Webb N, Anderson E, McNally D, Brisson J, et al. The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway. FEBS J. 2009;276:2686-2700 pubmed publisher
    ..Comparison of the active sites and amino acid sequences suggests that a conserved amino acid side chain (Arg185 in P. aeruginosa GMD) may be crucial for orienting substrate and cofactor in GMD enzymes. ..
  5. Boehr D, Thompson P, Wright G. Molecular mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: roles of conserved active site residues. J Biol Chem. 2001;276:23929-36 pubmed
    ..These results lay the foundation for the synthesis of transition state mimics that could reverse aminoglycoside antibiotic resistance in vivo. ..
  6. Lavaud J, Six C, Campbell D. Photosystem II repair in marine diatoms with contrasting photophysiologies. Photosynth Res. 2016;127:189-99 pubmed publisher
    ..The present work further confirms the important role for the light-dependent fast regulation of photochemistry by NPQ interacting with PSII repair cycle capacity in the ecophysiology of both pennate and centric diatoms. ..
  7. Corness J, Demchyshyn L, Seeman P, Van Tol H, Srikant C, Kent G, et al. A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. FEBS Lett. 1993;321:279-84 pubmed
  8. Zhang J, Liu Z, Masumiya H, Wang R, Jiang D, Li F, et al. Three-dimensional localization of divergent region 3 of the ryanodine receptor to the clamp-shaped structures adjacent to the FKBP binding sites. J Biol Chem. 2003;278:14211-8 pubmed
    ..6 binding. These results provide a structural basis for the role of the DR3 region in excitation-contraction coupling and in channel regulation. ..
  9. Gaudreau R, Beaulieu M, Chen Z, Le Gouill C, Lavigne P, Stankova J, et al. Structural determinants regulating expression of the high affinity leukotriene B4 receptor: involvement of dileucine motifs and alpha-helix VIII. J Biol Chem. 2004;279:10338-45 pubmed

More Information

Publications163 found, 100 shown here

  1. Hollenstein M, Hipolito C, Lam C, Perrin D. A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+). Nucleic Acids Res. 2009;37:1638-49 pubmed publisher
  2. McDonald B, Pittman K, Menezes G, Hirota S, Slaba I, Waterhouse C, et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science. 2010;330:362-6 pubmed publisher
    ..Thus, dynamic in vivo imaging revealed a multistep hierarchy of directional cues that guide neutrophil localization to sites of sterile inflammation. ..
  3. Kobsar D, Olson C, Paranjape R, Hadjistavropoulos T, Barden J. Evaluation of age-related differences in the stride-to-stride fluctuations, regularity and symmetry of gait using a waist-mounted tri-axial accelerometer. Gait Posture. 2014;39:553-7 pubmed publisher
    ..The findings also suggest the presence of an age-related decline in the anteroposterior control of gait, but not in the vertical and mediolateral control of gait. ..
  4. Boilard E, Surette M. Anti-CD3 and concanavalin A-induced human T cell proliferation is associated with an increased rate of arachidonate-phospholipid remodeling. Lack of involvement of group IV and group VI phospholipase A2 in remodeling and increased susceptibility of p. J Biol Chem. 2001;276:17568-75 pubmed
    ..Altogether these results indicate that increased arachidonate-phospholipid remodeling is associated with T cell proliferation and that CoA-independent transacylase may be a novel therapeutic target for proliferative disorders. ..
  5. Béliveau F, Desilets A, Leduc R. Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides. FEBS J. 2009;276:2213-26 pubmed publisher
    ..In summary, our studies revealed that these enzymes have distinct substrate preferences. ..
  6. Brown J, McClelland G, Faure P, Klaiman J, Staples J. Examining the mechanisms responsible for lower ROS release rates in liver mitochondria from the long-lived house sparrow (Passer domesticus) and big brown bat (Eptesicus fuscus) compared to the short-lived mouse (Mus musculus). Mech Ageing Dev. 2009;130:467-76 pubmed publisher
    ..Taken together these data suggest that complexes I and III are less reduced under physiological conditions in sparrows. We conclude that different long-lived species may use distinct mechanisms to lower mitochondrial ROS release rate...
  7. Petric R, Nicholson D, Ford Hutchinson A. Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. Biochim Biophys Acta. 1995;1254:207-15 pubmed
    ..05). These results suggest a potential mechanism for enhanced cysteinyl LT formation in the development of experimental GN and further support their causal role in the etiology of this disease. ..
  8. Okada H, Bakal C, Shahinian A, Elia A, Wakeham A, Suh W, et al. Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. J Exp Med. 2004;199:399-410 pubmed
    ..Thus, survivin plays a critical role in early thymocyte development. ..
  9. Deffrasnes C, Cote S, Boivin G. Analysis of replication kinetics of the human metapneumovirus in different cell lines by real-time PCR. J Clin Microbiol. 2005;43:488-90 pubmed
    ..Our results indicate that hMPV replicates slightly more efficiently in LLC-MK2 than in Vero cells and poorly in HEp-2 cells. ..
  10. Seah S, Ke J, Denis G, Horsman G, Fortin P, Whiting C, et al. Characterization of a C-C bond hydrolase from Sphingomonas wittichii RW1 with novel specificities towards polychlorinated biphenyl metabolites. J Bacteriol. 2007;189:4038-45 pubmed
    ..This study demonstrates that the substrate specificities of evolutionarily divergent hydrolases may be useful for degrading mixtures of pollutants, such as PCBs. ..
  11. Dresen C, Lin L, D Angelo I, Tocheva E, Strynadka N, Eltis L. A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism. J Biol Chem. 2010;285:22264-75 pubmed publisher
    ..Overall, the structural and functional data establish the physiological role of HsaAB and provide a basis to further investigate an important class of monooxygenases as well as the bacterial catabolism of steroids. ..
  12. Yang Y, Johnson J. Multi-parameter single-cell kinetic analysis reveals multiple modes of cell death in primary pancreatic β-cells. J Cell Sci. 2013;126:4286-95 pubmed publisher
    ..We conclude that apoptosis is not the primary mode of adult primary β-cell death. ..
  13. McFarlane Anderson N, Bailly J, Bégin Heick N. Levels of G-proteins in liver and brain of lean and obese (ob/ob) mice. Biochem J. 1992;282 ( Pt 1):15-23 pubmed
    ..Different rates of release of the alpha-subunits from the membrane and/or different rates of degradation would also explain these results. ..
  14. Kurniawati S, Nicell J. A comprehensive kinetic model of laccase-catalyzed oxidation of aqueous phenol. Biotechnol Prog. 2009;25:763-73 pubmed publisher
    ..Excellent agreement was found between model predictions of phenol and oxygen concentrations and experimental data over time for a wide range of initial substrate concentrations and enzyme activities. ..
  15. Tocheva E, Eltis L, Murphy M. Conserved active site residues limit inhibition of a copper-containing nitrite reductase by small molecules. Biochemistry. 2008;47:4452-60 pubmed publisher
    ..Overall, the data substantiate the roles of Asp98 and Ile257 in discriminating substrate from other small anions. ..
  16. Arcand N, Kluepfel D, Paradis F, Morosoli R, Shareck F. Beta-mannanase of Streptomyces lividans 66: cloning and DNA sequence of the manA gene and characterization of the enzyme. Biochem J. 1993;290 ( Pt 3):857-63 pubmed
    ..of 205 i.u./mg of enzyme and a Km of 0.77 mg/ml. Data from SDS/PAGE and Western blotting show that the cloned enzyme was identical to that of the wild-type strain...
  17. Forrester S, Prichard R, Beech R. A glutamate-gated chloride channel subunit from Haemonchus contortus: expression in a mammalian cell line, ligand binding, and modulation of anthelmintic binding by glutamate. Biochem Pharmacol. 2002;63:1061-8 pubmed
    ..These results also indicate that it may be possible to enhance the efficacy of macrocyclic lactone anthelmintics by administering these compounds with ligands acting allosterically to enhance their binding. ..
  18. Chang H, Shi R, Rehse P, Lin S. Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. J Biol Chem. 2004;279:2689-96 pubmed
    ..Our results identify that this human enzyme is an ADT sulfotransferase as well as a DHEA sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver. ..
  19. Wang J, Zhang Y, Wang H, Han H, Nattel S, Yang B, et al. Potential mechanisms for the enhancement of HERG K+ channel function by phospholipid metabolites. Br J Pharmacol. 2004;141:586-99 pubmed
    ..The increase in I(HERG) is best described by direct interactions between lipid molecules and HERG proteins, which is consistent with lack of effects via membrane destabilization or modulation by intracellular signaling pathways. ..
  20. Favetta L, St John E, King W, Betts D. High levels of p66shc and intracellular ROS in permanently arrested early embryos. Free Radic Biol Med. 2007;42:1201-10 pubmed
    ..These results further substantiate that p66shc and oxidative stress are associated with a p53-independent embryonic arrest event for in vitro-produced embryos. ..
  21. Chatelier A, Dahllund L, Eriksson A, Krupp J, Chahine M. Biophysical properties of human Na v1.7 splice variants and their regulation by protein kinase A. J Neurophysiol. 2008;99:2241-50 pubmed publisher
    ..7 can specifically modulate the biophysical properties and cAMP-mediated regulation of this channel. Changing the proportions of these variants may thus influence neuronal excitability and pain sensation. ..
  22. Goupil E, Laporte S, Hébert T. A simple method to detect allostery in GPCR dimers. Methods Cell Biol. 2013;117:165-79 pubmed publisher
    ..This assay measures time-dependent ligand occupancy of radiolabeled orthosteric or (with adaptations) allosteric ligands as modulated by either small molecules or receptor dimer partners bound or unbound with their own ligands. ..
  23. St Pierre M, Pang K. Kinetics of sequential metabolism. II. Formation and metabolism of nordiazepam and oxazepam from diazepam in the perfused murine liver. J Pharmacol Exp Ther. 1993;265:1437-45 pubmed
    ..The atypical kinetic behavior of generated NZ may have also influenced the ensuing metabolic fate of its product, OZ, such that E[OZ,NZ] approximately E[OZ,DZ].(ABSTRACT TRUNCATED AT 250 WORDS) ..
  24. Duong M, Ouellet N, Simard M, Bergeron Y, Olivier M, Bergeron M. Kinetic study of host defense and inflammatory response to Aspergillus fumigatus in steroid-induced immunosuppressed mice. J Infect Dis. 1998;178:1472-82 pubmed
    ..These insights may be useful in the development of new treatment strategies for pulmonary aspergillosis. ..
  25. Coady M, Chang M, Charron F, Plata C, Wallendorff B, Sah J, et al. The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. J Physiol. 2004;557:719-31 pubmed
    ..The significance of a Na(+)-monocarboxylate transporter to colon cancer presumably stems from the transport of butyrate, which is well known for having anti-proliferative and apoptosis-inducing activity in colon epithelial cells. ..
  26. Cloutier G, Daronatand M, Savery D, Garcia D, Durand L, Foster F. Non-Gaussian statistics and temporal variations of the ultrasound signal backscattered by blood at frequencies between 10 and 58 MHz. J Acoust Soc Am. 2004;116:566-77 pubmed
  27. Perroy J, Pontier S, Charest P, Aubry M, Bouvier M. Real-time monitoring of ubiquitination in living cells by BRET. Nat Methods. 2004;1:203-8 pubmed
    ..The ubiquitination BRET assay should prove to be a useful tool for studying the dynamic ubiquitination of proteins and for understanding which cellular functions are regulated by this post-translational event. ..
  28. Paradis Bleau C, Lloyd A, Sanschagrin F, Clarke T, Blewett A, Bugg T, et al. Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF. BMC Biochem. 2008;9:33 pubmed publisher
    ..We present the first peptide inhibitor of MurF, an enzyme that should be exploited as a target for antimicrobial drug development. ..
  29. Basak A, Chen A, Scamuffa N, Mohottalage D, Basak S, Khatib A. Blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain. Curr Med Chem. 2010;17:2214-21 pubmed
    ..This suggests that the combined presence of the above two prodomain segments is crucial for prodomain's potent furin-inhibitory and hence anticancer activities. ..
  30. Guintini L, Tremblay M, Toussaint M, D Amours A, Wellinger R, Wellinger R, et al. Repair of UV-induced DNA lesions in natural Saccharomyces cerevisiae telomeres is moderated by Sir2 and Sir3, and inhibited by yKu-Sir4 interaction. Nucleic Acids Res. 2017;45:4577-4589 pubmed publisher
    ..The telomere terminal complex also prevents NER, however, this effect is largely dependent on the yKu-Sir4 interaction, but Sir2 and Sir3 independent. ..
  31. Trudel G, Holland P. Effect of inhibitors of glycoprotein processing on integrin and the adhesion of myoblasts to extracellular matrix proteins. Biochem Biophys Res Commun. 1989;163:1338-43 pubmed
    ..We suggest that the previously reported inhibitory effects of glucosidase inhibitors on the terminal differentiation of myoblasts may be mediated, at least in part, through their effect on integrin accumulation. ..
  32. Bryant R, Laishley E. Evidence for proton motive force dependent transport of selenite by Clostridium pasteurianum. Can J Microbiol. 1989;35:481-6 pubmed
    ..The SeO3(2-) porter system in C. pasteurianum was found to be dependent upon energy source, temperature, and medium pH. ..
  33. Zaher H, Unrau P. A general RNA-capping ribozyme retains stereochemistry during cap exchange. J Am Chem Soc. 2006;128:13894-900 pubmed
    ..As all protein enzymes that mediate similar capping reactions utilize a covalent intermediate, chemical necessity may have strongly guided the evolution of both protein and RNA-capping catalysts. ..
  34. Capyk J, D Angelo I, Strynadka N, Eltis L. Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis. J Biol Chem. 2009;284:9937-46 pubmed publisher
    ..This study provides a solid basis for further studies of a key steroid-transforming enzyme of biotechnological and medical importance...
  35. Gingras D, Menard P, Beliveau R. Protein carboxyl methylation in kidney brush-border membranes. Biochim Biophys Acta. 1991;1066:261-7 pubmed
  36. Morris C, Montpetit M, Sigurdson W, Iwasa K. Activation by curare of acetylcholine receptor channels in a murine skeletal muscle cell line. Can J Physiol Pharmacol. 1989;67:152-8 pubmed
    ..The outcome is (a) an agonist action too feeble to perturb the membrane voltage and (b) a powerful competitive antagonist action. ..
  37. Beaulieu M, Levesque E, Hum D, Belanger A. Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids. J Biol Chem. 1996;271:22855-62 pubmed
    ..UGT2B17 is the first human uridine diphosphoglucuronosyltransferase enzyme expressed in extrahepatic tissues to have a specificity for ADT as well as testosterone, dihydrotestosterone, and 3alpha-diol. ..
  38. Marshall A, Fleming H, Wu G, Paige C. Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression. J Immunol. 1998;161:6038-45 pubmed
    ..Our results suggest that positive selection of pre-BCR+ pro-B cells may be achieved through the fine tuning of IL-7 responses. ..
  39. Koenig K, Rode L, Knight C, McCullough P. Ruminal escape, gastrointestinal absorption, and response of serum methionine to supplementation of liquid methionine hydroxy analog in dairy cows. J Dairy Sci. 1999;82:355-61 pubmed
    ..3%). Serum methionine concentration peaked 6 h after analog dosing at a level that was three times the predose level, indicating that the methionine analog that escaped ruminal degradation was absorbed and metabolized to methionine. ..
  40. Gingras M, Zhang Y, Kharitidi D, Barr A, Knapp S, Tremblay M, et al. HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. PLoS ONE. 2009;4:e5105 pubmed publisher
    ..As such, we identify one residue involved in its inactivation and show that its colony growth reduction activity is independent of its PTP activity status in human cancer cell lines. ..
  41. Benoit Biancamano M, Adam J, Bernard O, Court M, Leblanc M, Caron P, et al. A pharmacogenetics study of the human glucuronosyltransferase UGT1A4. Pharmacogenet Genomics. 2009;19:945-54 pubmed publisher
    ..Besides, several coding variants significantly modified the enzyme kinetics for tamoxifen and Z-4-hydroxytamoxifen (Val??, Asp??, Gln??, Phe¹??, Asn²??, Leu²??) and are expected to have a potential in vivo effect. ..
  42. Belatik A, Hotchandani S, Bariyanga J, Tajmir Riahi H. Binding sites of retinol and retinoic acid with serum albumins. Eur J Med Chem. 2012;48:114-23 pubmed publisher
    ..The results indicate that serum albumins are capable of transporting retinoids in vitro and in vivo. ..
  43. Zitouni M, Fortin M, Scheerle R, Letzel T, Matteau D, Rodrigue S, et al. Biochemical and molecular characterization of a thermostable chitosanase produced by the strain Paenibacillus sp. 1794 newly isolated from compost. Appl Microbiol Biotechnol. 2013;97:5801-13 pubmed publisher
    ..The enzyme should be useful in biotechnological applications of chitosan hydrolysis, dealing with concentrated chitosan solutions at high temperatures. ..
  44. Currie S, Lau D, Doane J, Whitby F, Okon M, McIntosh L, et al. Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5. Nucleic Acids Res. 2017;45:2223-2241 pubmed publisher
    ..These distinguishing inhibitory elements provide a platform through which cellular triggers, such as protein-protein interactions or post-translational modifications, may specifically regulate the function of these oncogenic proteins. ..
  45. Brandes L, Queen G, LaBella F. Displacement of histamine from liver cells and cell components by ligands for cytochromes P450. J Cell Biochem. 2002;85:820-4 pubmed
  46. Beharry A, Sadovski O, Woolley G. Photo-control of peptide conformation on a timescale of seconds with a conformationally constrained, blue-absorbing, photo-switchable linker. Org Biomol Chem. 2008;6:4323-32 pubmed publisher
    ..This cross-linker design thus expands the possibilities for fast photo-control of peptide and protein structure in biochemical systems. ..
  47. Toyota B, Carbonetto S, David S. A dual laminin/collagen receptor acts in peripheral nerve regeneration. Proc Natl Acad Sci U S A. 1990;87:1319-22 pubmed
    ..These data provide evidence that an integrin receptor functions in nerve regeneration in vivo. ..
  48. Estall J, Koehler J, Yusta B, Drucker D. The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation. J Biol Chem. 2005;280:22124-34 pubmed
  49. Brayer G, Sidhu G, Maurus R, Rydberg E, Braun C, Wang Y, et al. Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry. 2000;39:4778-91 pubmed
    ..Structural analyses of the Asp300Asn variant of human pancreatic alpha-amylase and its complex with acarbose clearly demonstrate the importance of Asp300 to the mode of inhibitor binding. ..
  50. Paradis Bleau C, Lloyd A, Sanschagrin F, Maaroufi H, Clarke T, Blewett A, et al. Pseudomonas aeruginosa MurE amide ligase: enzyme kinetics and peptide inhibitor. Biochem J. 2009;421:263-72 pubmed publisher
    ..Identification of the MurEp1 residues involved in MurE binding and inhibition will allow the development of a novel class of inhibitors having a novel mode of action against MurE...
  51. Shi R, Chen Z, Zhu D, Li C, Shan Y, Xu G, et al. Crystal structures of human muscle fructose-1,6-bisphosphatase: novel quaternary states, enhanced AMP affinity, and allosteric signal transmission pathway. PLoS ONE. 2013;8:e71242 pubmed publisher
  52. Rachel N, Pelletier J. One-pot peptide and protein conjugation: a combination of enzymatic transamidation and click chemistry. Chem Commun (Camb). 2016;52:2541-4 pubmed publisher
    ..Tuning the reaction kinetics was key to success, providing up to 95% conversion. This one-pot reaction allowed for targeted fluorescent protein labeling. ..
  53. Szerencsei R, Prinsen C, Schnetkamp P. Stoichiometry of the retinal cone Na/Ca-K exchanger heterologously expressed in insect cells: comparison with the bovine heart Na/Ca exchanger. Biochemistry. 2001;40:6009-15 pubmed
    ..The calcium dependence of (45)Ca uptake yielded values between 1 and 2.5 microM for the external calcium dissociation constant of the different NCKX proteins studied here. ..
  54. Ouellet J, Perreault J. Cross-linking experiments reveal the presence of novel structural features between a hepatitis delta virus ribozyme and its substrate. RNA. 2004;10:1059-72 pubmed
    ..To provide a model representation of these data, a three-dimensional structure of the delta ribozyme was developed using several RNA bioinformatic software packages. ..
  55. Park S, Kang H, Shim J, Woo E, Hong J, Kim J, et al. Modulation of substrate preference of thermus maltogenic amylase by mutation of the residues at the interface of a dimer. Biosci Biotechnol Biochem. 2007;71:1564-7 pubmed
    ..Thus, the substituted bulky amino acid residues modified the shape of the catalytic site, such that the ability of the enzyme to distinguish between small and large molecules like amylose and amylopectin was enhanced...
  56. Wang W, Zhang Y, Ye R, Ni Y. Physical crosslinkings of edible collagen casing. Int J Biol Macromol. 2015;81:920-5 pubmed publisher
    ..The physical treatments could potentially be used as safe and effective alternatives to chemical cross-linking for the production of collage casing. ..
  57. De Kauwe M, Lin Y, Wright I, Medlyn B, Crous K, Ellsworth D, et al. A test of the 'one-point method' for estimating maximum carboxylation capacity from field-measured, light-saturated photosynthesis. New Phytol. 2016;210:1130-44 pubmed publisher
    ..1 μmol m(-2) s(-1) . The one-point method provides a robust means to expand current databases of field-measured Vcmax , giving new potential to improve vegetation models and quantify the environmental drivers of Vcmax variation. ..
  58. Thilakarathna S, Rogers M, Lan Y, Huynh S, Marangoni A, Robinson L, et al. Investigations of in vitro bioaccessibility from interesterified stearic and oleic acid-rich blends. Food Funct. 2016;7:1932-40 pubmed publisher
    ..8640) with postprandial serum TAG concentration in the human study. Therefore, the in vitro digestion model offered predictive insights related to the impacts of lipid interesterificaton on absorption. ..
  59. Bi H, Masse R. Studies on anabolic steroids--12. Epimerization and degradation of anabolic 17 beta-sulfate-17 alpha-methyl steroids in human: qualitative and quantitative GC/MS analysis. J Steroid Biochem Mol Biol. 1992;42:533-46 pubmed
    ..The urinary excretion profiles of the epimeric and 18-nor-17,17-dimethyl-13(14)-ene steroids are presented and discussed on the basis of their structural features. ..
  60. Gruenheid S, DeVinney R, Bladt F, Goosney D, Gelkop S, Gish G, et al. Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells. Nat Cell Biol. 2001;3:856-9 pubmed
    ..Cells with null alleles of both mammalian Nck genes are resistant to the effects of EPEC on the actin cytoskeleton. These results implicate Nck adaptors as host-cell determinants of EPEC virulence. ..
  61. Gidda S, Miersch O, Levitin A, Schmidt J, Wasternack C, Varin L. Biochemical and molecular characterization of a hydroxyjasmonate sulfotransferase from Arabidopsis thaliana. J Biol Chem. 2003;278:17895-900 pubmed
    ..Alternatively, the function of AtST2a might be to control the biological activity of 12-hydroxyjasmonic acid. ..
  62. Denis M, Landry Y, Zha X. ATP-binding cassette A1-mediated lipidation of apolipoprotein A-I occurs at the plasma membrane and not in the endocytic compartments. J Biol Chem. 2008;283:16178-86 pubmed publisher
    ..We therefore conclude that the plasma membrane is the main platform where ABCA1-mediated lipidation of apoA-I occurs...
  63. Basak A, Cooper S, Roberge A, Banik U, Chretien M, Seidah N. Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Biochem J. 1999;338 ( Pt 1):107-13 pubmed
  64. Yang C, Plackett D, Needham D, Burt H. PLGA and PHBV microsphere formulations and solid-state characterization: possible implications for local delivery of fusidic acid for the treatment and prevention of orthopaedic infections. Pharm Res. 2009;26:1644-56 pubmed publisher
    ..A unique phase separation phenomenon of FA in PLGA but not in PHBV polymers was observed, driven by coalescence of liquid microdroplets of a DCM-FA-rich phase in the forming microsphere. ..
  65. Hallenbeck P, Gennaro G. Stopped-flow kinetic studies of low potential electron carriers of the photosynthetic bacterium, Rhodobacter capsulatus: ferredoxin I and NifF. Biochim Biophys Acta. 1998;1365:435-42 pubmed
    ..Moreover, the apparent lack of specific interaction between NifF and FdI suggest that they act in vivo in parallel to reduce Fe-protein and not in series. ..
  66. Fausther M, Lecka J, Kukulski F, Lévesque S, Pelletier J, Zimmermann H, et al. Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8. Am J Physiol Gastrointest Liver Physiol. 2007;292:G785-95 pubmed
    ..The canalicular localization of this enzyme suggests its involvement in the regulation of bile secretion and/or nucleoside salvage. ..
  67. Gingras D, Beliveau R. Guanine nucleotides stimulate carboxyl methylation of kidney cytosolic proteins. Biochim Biophys Acta. 1992;1136:150-4 pubmed
    ..These results suggest that class-II-associated protein methylation activity from the soluble fraction of the kidney can be regulated by guanine nucleotides. ..
  68. Xiao H, Briere L, Dunn S, Yada R. Characterization of the monomer-dimer equilibrium of recombinant histo-aspartic protease from Plasmodium falciparum. Mol Biochem Parasitol. 2010;173:17-24 pubmed publisher
    ..0 microM and a turnover number, k(cat), of 0.036s(-1) using the internally quenched fluorescent synthetic peptide substrate EDANS-CO-CH(2)-CH(2)-CO-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap-(DABCYL)-OH (2837b) at pH 5.2...
  69. Du C, Mendelson A, Guan Q, Chapanian R, Chafeeva I, da Roza G, et al. The size-dependent efficacy and biocompatibility of hyperbranched polyglycerol in peritoneal dialysis. Biomaterials. 2014;35:1378-89 pubmed publisher
    ..These preclinical data indicate that compared to PYS, low MW HPGs (0.5-3 kDa) produces superior fluid and waste removal with better biocompatibility profile, suggesting that they are promising osmotic agents for PD. ..
  70. Filippou P, Farkona S, Brinc D, Yu Y, Prassas I, Diamandis E. Biochemical and functional characterization of the human tissue kallikrein 9. Biochem J. 2017;474:2417-2433 pubmed publisher
    ..Taken together, our data delineate some functional and biochemical properties of KLK9 for future elucidation of the role of this enzyme in health and disease. ..
  71. Redden P, Melanson R, Douglas J, Dick A. Acyloxymethyl acidic drug derivatives: in vitro hydrolytic reactivity. Int J Pharm. 1999;180:151-60 pubmed
  72. Arnot J, Gobas F. A food web bioaccumulation model for organic chemicals in aquatic ecosystems. Environ Toxicol Chem. 2004;23:2343-55 pubmed
    ..The new model is able to provide better estimates of bioaccumulation factors in comparison to the previous food web bioaccumulation model while the model input requirements remain largely unchanged. ..
  73. Haince J, McDonald D, Rodrigue A, Déry U, Masson J, Hendzel M, et al. PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J Biol Chem. 2008;283:1197-208 pubmed
    ..This may explain the sensitivity of cancer cells to PARP inhibitors. ..
  74. St Pierre M, Pang K. Kinetics of sequential metabolism. I. Formation and metabolism of oxazepam from nordiazepam and temazepam in the perfused murine liver. J Pharmacol Exp Ther. 1993;265:1429-36 pubmed
    ..abstract truncated at 250 words) ..
  75. Pelletier M, Marcil A, Sevigny G, Jakob C, Tessier D, Chevet E, et al. The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo. Glycobiology. 2000;10:815-27 pubmed
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