Experts and Doctors on keratinocytes in South Korea


Locale: South Korea
Topic: keratinocytes

Top Publications

  1. Piao M, Zhang R, Lee N, Hyun J. Protective effect of triphlorethol-A against ultraviolet B-mediated damage of human keratinocytes. J Photochem Photobiol B. 2012;106:74-80 pubmed publisher
    ..These results suggest that triphlorethol-A protects human keratinocytes against UVB by enhancing the activities of the antioxidant system, inhibiting cellular damage and absorbing the UVB. ..
  2. Wi H, Na E, Yun S, Lee J. The antifungal effect of light emitting diode on Malassezia yeasts. J Dermatol Sci. 2012;67:3-8 pubmed publisher
    ..The findings suggest that LED might be an adjunctive therapeutic light tool against Malassezia yeasts related cutaneous diseases. ..
  3. Kim S, Nam G, Lee H, Moon S, Chang I. The effects of Musk T on peroxisome proliferator-activated receptor [PPAR]-alpha activation, epidermal skin homeostasis and dermal hyaluronic acid synthesis. Arch Dermatol Res. 2006;298:273-82 pubmed
    ..Through these experiments, we conclude that Musk T is PPAR-alpha ligand, effects on keratinocyte differentiation, intercellular lipid synthesis in epidermis, HA synthesis stimulation in dermis. ..
  4. Kim N, Jeon S, Lee H, Lee A. Impaired PI3K/Akt activation-mediated NF-kappaB inactivation under elevated TNF-alpha is more vulnerable to apoptosis in vitiliginous keratinocytes. J Invest Dermatol. 2007;127:2612-7 pubmed
    ..Thus, reduced activation of NF-kappaB via impaired PI3K/Akt activation under increased TNF-alpha levels could result in increased apoptosis of vitiliginous keratinocytes. ..
  5. Han C, Lim S, Choi H, Kang K. Induction of ErbB2 by ultraviolet A irradiation: potential role in malignant transformation of keratinocytes. Cancer Sci. 2008;99:502-9 pubmed publisher
  6. Kim N, Lee A. Reduced aquaporin3 expression and survival of keratinocytes in the depigmented epidermis of vitiligo. J Invest Dermatol. 2010;130:2231-9 pubmed publisher
    ..Moreover, AQP3 knockdown induced no increase in differentiating markers at high calcium concentrations and reduced survival of KCs, suggesting that reduced AQP3 in vitiliginous KCs might be responsible for their reduced survival. ..
  7. Piao M, Choi J, Lee D, Yun S, Lee J, Lee S. Differentiation-dependent expression of NADP(H):quinone oxidoreductase-1 via NF-E2 related factor-2 activation in human epidermal keratinocytes. J Dermatol Sci. 2011;62:147-53 pubmed publisher
    ..These results demonstrate that NQO-1 is modulated during KC differentiation via Nrf2 pathway, suggesting the active role of NQO-1 in the differentiating epidermis. ..
  8. Jeong S, Kim S, Bae C, Park J, Choi B, Wang G, et al. Delayed healing and induction of secretory leukocyte protease inhibitor in polycystic ovary syndrome rat skin wounds. Int J Mol Med. 2012;29:185-94 pubmed publisher
  9. Piao M, Zhang R, Lee N, Hyun J. Phloroglucinol attenuates ultraviolet B radiation-induced matrix metalloproteinase-1 production in human keratinocytes via inhibitory actions against mitogen-activated protein kinases and activator protein-1. Photochem Photobiol. 2012;88:381-8 pubmed publisher
    ..In addition, the knockdown of MAPKs significantly inhibited UVB-induced MMP-1 expression. The results of this study suggest that phloroglucinol may be useful as a photoprotective compound for the skin. ..

More Information


  1. Yoon J, Kim I, Kim H, Kim H, Jeong M, Ahn S, et al. Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells. Cancer Lett. 2005;222:237-45 pubmed
    ..The specific inhibition of LAT1 in oral cancer cells could be a new rationale for anti-cancer therapy. ..
  2. Byun S, Jeon I, Lee H, Kim T. IFN-gamma upregulates expression of the mouse complement C1rA gene in keratinocytes via IFN-regulatory factor-1. J Invest Dermatol. 2007;127:1187-96 pubmed
    ..We conclude that IFN-gamma stimulates mC1rA gene expression via IRF-1 in mouse keratinocytes. ..
  3. Thuong P, Kang K, Kim J, Seo D, Lee S, Kim S, et al. Lithospermic acid derivatives from Lithospermum erythrorhizon increased expression of serine palmitoyltransferase in human HaCaT cells. Bioorg Med Chem Lett. 2009;19:1815-7 pubmed publisher
    ..This finding suggests that lithospermic acid and its derivatives from L. erythrorhizon might improve the permeability barrier by stimulating the protein level of SPT...
  4. Kim N, Yoo J, Han J, Hwang E, Kim Y, Jeong E, et al. Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. J Cell Physiol. 2012;227:1157-67 pubmed publisher
    ..These results suggest a novel mechanism of apoptosis mediated by nCLU as a pro-apoptotic molecule. ..
  5. Ayush O, Lee C, Kim H, Im S, Cho B, Lee H. Glutamine suppresses DNFB-induced contact dermatitis by deactivating p38 mitogen-activated protein kinase via induction of MAPK phosphatase-1. J Invest Dermatol. 2013;133:723-731 pubmed publisher
    ..These results suggest that Gln suppresses DNFB-induced CD via deactivation of p38 MAPK through the early induction of MKP-1, the negative regulator of p38, in an ERK-dependent manner...
  6. Kim N, Choi S, Kim C, Lee C, Lee T, Lee A. Reduced MiR-675 in exosome in H19 RNA-related melanogenesis via MITF as a direct target. J Invest Dermatol. 2014;134:1075-1082 pubmed publisher
    ..Collectively, the results suggest that miR-675 derived from keratinocytes could be involved in H19-stimulated melanogenesis using MITF as a target of miR-675. ..