Experts and Doctors on karwinskia in Mexico
Salazar R, Rivas V, Gonzalez G, Waksman N. Antimicrobial activity of coupled hydroxyanthracenones isolated from plants of the genus Karwinskia. Fitoterapia. 2006;77:398-400 pubmed
..boidinii, C. glabrata and Cryptococcus neoformans; minimal inhibitory concentrations range between 16 and 2 microg/ml...
Garza Ocañas L, Zanatta Calderón M, Acosta D, Torres Alanis O, Piñeyro Lopez A. Production of reactive oxygen species by toxin T-514 of genus Karwinskia in vitro. Toxicol In Vitro. 2003;17:19-25 pubmed
..The results indicate that oxidative stress mediated by reactive intermediates may be a mechanism by which T-514 induces its cytotoxic effect...
Gómez Silva M, Garza Ocañas L, Waksman N, Rivas V, Piñeyro Lopez A. In vitro metabolism and toxicity assessment of toxin T-514 (Peroxisomicine A1) of Karwinskia humboldtiana in microsomes and primary cultured hepatocytes. Toxicol In Vitro. 2005;19:47-53 pubmed
..The cytotoxicity of the metabolites was evaluated in Chang liver and Hep G2 cells but they did not show the selective cytotoxic effect on tumor cells seen in the original compound...
Salazar Leal M, Flores M, Sepulveda Saavedra J, Romero Diaz V, Becerra Verdin E, Tamez Rodriguez V, et al
. An experimental model of peripheral neuropathy induced in rats by Karwinskia humboldtiana (buckthorn) fruit. J Peripher Nerv Syst. 2006;11:253-61 pubmed
..Its manipulation is relatively innocuous and allows us to study reversible peripheral nerve damage. This model can be developed in other animal species and may be useful to test new therapies for peripheral neuropathy...
Ocampo Roosens L, Ontiveros Nevares P, Fernández Lucio O. Intoxication with buckthorn (Karwinskia humboldtiana): report of three siblings. Pediatr Dev Pathol. 2007;10:66-8 pubmed
..The clinical diagnosis of intoxicated patients can be difficult without a history of the fruit ingestion. We present a report of three siblings with buckthorn intoxication...
Becerra Verdin E, Bermúdez Barba M, Salazar Leal M, Ancer Rodriguez J, Romero Diaz V, Soto Domínguez A, et al
. Karwinskia humboldtiana (buckthorn) fruit causes central nervous system damage during chronic intoxication in the rat. Toxicon. 2009;53:645-51 pubmed publisher
..With this methodology, we found lesions in the motor pathway. This is the first report about the presence of neuronal damage caused by Kh in the Central Nervous System in chronic intoxication...
DÃaz PÃ©rez R, Castillo GonzÃ¡lez J, CarcaÃ±o DÃaz K, GarcÃa JuÃ¡rez J, Salazar Leal M, MuÃ±oz Maldonado G, et al
. Histopathological alterations in the striatum caused by Karwinskia humboldtiana (Buckthorn) fruit in an experimental model of peripheral neuropathy. Histol Histopathol. 2016;31:393-402 pubmed publisher
..This study is the first report that describes the histopathological alterations within the striatum caused by chronic intoxication with Kh fruit in the Wistar rat. ..