Genomes and Genes
Experts and Doctors on k562 cells in United States
Locale: United States
Topic: k562 cells
Publications111 found, 100 shown here
- Jian W, Yan B, Huang S, Qiu Y. Histone deacetylase 1 activates PU.1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly. FASEB J. 2017;31:4104-4116 pubmed publisher..Jian, W., Yan, B., Huang, S., Qiu, Y. Histone deacetylase 1 activates PU.1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly. ..
- Zhou F, Liu Y, Rohde C, Pauli C, Gerloff D, Köhn M, et al. AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia. Nat Cell Biol. 2017;19:844-855 pubmed publisher..Collectively, these findings indicate that induction of C/D box snoRNA/RNP function constitutes an important pathway in leukaemogenesis. ..
- Jin Y, Liu S, Yu B, Golan S, Koh C, Yang J, et al. Targeted delivery of antisense oligodeoxynucleotide by transferrin conjugated pH-sensitive lipopolyplex nanoparticles: a novel oligonucleotide-based therapeutic strategy in acute myeloid leukemia. Mol Pharm. 2010;7:196-206 pubmed publisher..69 nM to 9.05 nM. This study suggests that the combination of pH sensitive LP formulation and Tf mediated targeting is a promising strategy for antisense ODN delivery in leukemia therapy. ..
- Turcotte R, Raines R. Design and characterization of an HIV-specific ribonuclease zymogen. AIDS Res Hum Retroviruses. 2008;24:1357-63 pubmed publisher..By relying on the proper function of HIV-1 protease, rather than its inhibition, our approach will not engender known mechanisms of resistance. Thus, we report an initial step toward a new class of agents for the treatment of HIV/AIDS. ..
- Beharry Z, Mahajan S, Zemskova M, Lin Y, Tholanikunnel B, Xia Z, et al. The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci U S A. 2011;108:528-33 pubmed publisher..These results demonstrate the Pim kinase-mediated control of energy metabolism and thus regulation of AMPK activity. We identify an important role for Pim-3 in modulating c-Myc and PGC-1? protein levels and cell growth. ..
- Lou Z, Jevremovic D, Billadeau D, Leibson P. A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts during the development of cell-mediated killing. J Exp Med. 2000;191:347-54 pubmed..These results suggest that the influence of integrated positive and negative signals on raft redistribution critically influences the development of cell-mediated cytotoxicity. ..
- Johnson R, Chao T, Lavis L, Raines R. Cytotoxic ribonucleases: the dichotomy of Coulombic forces. Biochemistry. 2007;46:10308-16 pubmed..Thus, Coulombic forces mediate extracellular and intracellular equilibria in a dichotomous manner that both endangers cells and defends them from the potentially lethal enzymatic activity of ribonucleases. ..
- Koh C, Zhang X, Liu S, Golan S, Yu B, Yang X, et al. Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing. J Control Release. 2010;141:62-9 pubmed publisher..MF LP nanoparticles had higher level of Bcl-2 antisense uptake and showed more efficient down-regulation of Bcl-2 protein level than BM LP nanoparticles. ..
- Neviani P, Santhanam R, Trotta R, Notari M, Blaser B, Liu S, et al. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell. 2005;8:355-68 pubmed..Thus, functional inactivation of PP2A is essential for BCR/ABL leukemogenesis and, perhaps, required for blastic transformation...
- Nagavarapu U, Danthi S, Boyd R. Characterization of a rat neuronal nicotinic acetylcholine receptor alpha7 promoter. J Biol Chem. 2001;276:16749-57 pubmed..Several transcription factors interact in close proximity to control expression of the rat alpha7 nicotinic receptor gene. ..
- Yang J, Kawai Y, Hanson R, Arinze I. Sodium butyrate induces transcription from the G alpha(i2) gene promoter through multiple Sp1 sites in the promoter and by activating the MEK-ERK signal transduction pathway. J Biol Chem. 2001;276:25742-52 pubmed..These results show that the MEK-ERK signal transduction pathway is important in butyrate signaling, which eventually converges in the cell nucleus. ..
- Hahn C, Lowrey C. Eukaryotic initiation factor 2? phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism. Blood. 2013;122:477-85 pubmed publisher..Taken together, these findings identify eIF2? phosphorylation as a post-transcriptional regulator of HbF induction that may be pharmacologically targeted, either alone or in combination, in ?-hemoglobinopathy patients. ..
- Awasthi S, Singhal S, Singhal J, Cheng J, Zimniak P, Awasthi Y. Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76. Int J Oncol. 2003;22:713-20 pubmed..These studies demonstrate that DOX transport activity of RLIP76 is significantly greater in NSCLC as compared with SCLC, and that RLIP76 is the major DOX transporter in lung cancer cell lines...
- Wang H, Zhang Y, Cheng Y, Zhou Y, King D, Taylor J, et al. Experimental validation of predicted mammalian erythroid cis-regulatory modules. Genome Res. 2006;16:1480-92 pubmed..Genome-wide predictions based on RP and a large set of well-defined transcription factor binding sites are available through servers at http://www.bx.psu.edu/. ..
- Toska E, Campbell H, Shandilya J, Goodfellow S, Shore P, Medler K, et al. Repression of transcription by WT1-BASP1 requires the myristoylation of BASP1 and the PIP2-dependent recruitment of histone deacetylase. Cell Rep. 2012;2:462-9 pubmed publisher..Our findings uncover a role for myristoylation in transcription, as well as a critical function for PIP2 in gene-specific transcriptional repression through the recruitment of histone deacetylase. ..
- Chiu S, Liu S, Perrotti D, Marcucci G, Lee R. Efficient delivery of a Bcl-2-specific antisense oligodeoxyribonucleotide (G3139) via transferrin receptor-targeted liposomes. J Control Release. 2006;112:199-207 pubmed..8 microM to 0.18 microM. In conclusion, Tf-conjugated liposomes are effective delivery vehicles for G3139 antisense oligos in TfR positive K562 cells and warrant further investigation as an in vivo oligo delivery vehicle. ..
- Hendrie P, Huo Y, Stolitenko R, Russell D. A rapid and quantitative assay for measuring neighboring gene activation by vector proviruses. Mol Ther. 2008;16:534-40 pubmed publisher..Although the pACT assay does not measure oncogenesis directly, it should be useful for screening vectors before more time-consuming and costly animal studies are undertaken. ..
- Drake K, Singhal J, Yadav S, Nadkar A, Pungaliya C, Singhal S, et al. RALBP1/RLIP76 mediates multidrug resistance. Int J Oncol. 2007;30:139-44 pubmed..Conversely, inhibition of RALBP1 by polyclonal antibodies causes increased drug-accumulation and increased cytotoxicity. These studies demonstrate the potential utility of targeting RALBP1 in the treatment of leukemia...
- Satoh M, Chan J, Ross S, Li Y, Yamasaki Y, Yamada H, et al. Autoantibodies to transcription intermediary factor TIF1? associated with dermatomyositis. Arthritis Res Ther. 2012;14:R79 pubmed publisher..Anti-TIF1? is a new DM autoantibody associated with a mild form of myopathy. Whether it has an association with malignancy, as in the case of anti-TIF1?, or other unique features will need to be evaluated in future studies. ..
- Thongngarm T, Jenkins J, Ndebele K, McMurray R. Estrogen and progesterone modulate monocyte cell cycle progression and apoptosis. Am J Reprod Immunol. 2003;49:129-38 pubmed..Further investigation should provide a better understanding of pregnancy-induced immune changes and, perhaps, sex-based differences in monocyte function and immunologic responses. ..
- Layon M, Ackley C, West R, Lowrey C. Expression of GATA-1 in a non-hematopoietic cell line induces beta-globin locus control region chromatin structure remodeling and an erythroid pattern of gene expression. J Mol Biol. 2007;366:737-44 pubmed..These results imply that GATA-1 is sufficient to direct chromatin structure reorganization within the beta-globin LCR and an erythroid pattern of gene expression in the absence of other hematopoietic transcription factors. ..
- Lee B, Bhinge A, Battenhouse A, McDaniell R, Liu Z, Song L, et al. Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells. Genome Res. 2012;22:9-24 pubmed publisher..These data illuminate how combinatorial binding of transcription factors in diverse cell types is associated with gene expression and cell-type specific biology...
- Shi Y, Dodson G, Mukhopadhyay P, Shanware N, Trinh A, Tibbetts R. Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. J Biol Chem. 2007;282:9236-43 pubmed..Our findings also suggest that DSQ motifs are common phosphoacceptor motifs for ATM family kinases. ..
- Chen A, Zhang E, Guan W, Cheng F, Kleiboeker S, Yankee T, et al. The small 11 kDa nonstructural protein of human parvovirus B19 plays a key role in inducing apoptosis during B19 virus infection of primary erythroid progenitor cells. Blood. 2010;115:1070-80 pubmed publisher..Taken together, these results demonstrate that the 11 kDa protein contributes to erythroid progenitor cell death during B19V infection...
- Mergia A, Chari S, Kolson D, Goodenow M, Ciccarone T. The efficiency of simian foamy virus vector type-1 (SFV-1) in nondividing cells and in human PBLs. Virology. 2001;280:243-52 pubmed..Together, these data indicate that SFV-1 based retroviral vectors may provide a safe, efficient alternative to current onco- and lentiviral vectors for gene transfer in cells from a broad spectrum of lineages across species boundaries. ..
- Johnson R, McCoy J, Bingman C, Phillips G, Raines R. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. J Mol Biol. 2007;368:434-49 pubmed..Together, these results provide new insight into an unusual and important protein-protein interaction, and could expedite the development of human ribonucleases as chemotherapeutic agents. ..
- Lee J, Bae E, Bingman C, Phillips G, Raines R. Structural basis for catalysis by onconase. J Mol Biol. 2008;375:165-77 pubmed..No variant, however, was more toxic to human cancer cells than wild-type ONC. Together, these findings provide a cynosure for understanding catalysis of RNA cleavage in a system of high medicinal relevance. ..
- Yu X, Zhu X, Pi W, Ling J, Ko L, Takeda Y, et al. The long terminal repeat (LTR) of ERV-9 human endogenous retrovirus binds to NF-Y in the assembly of an active LTR enhancer complex NF-Y/MZF1/GATA-2. J Biol Chem. 2005;280:35184-94 pubmed
- Soundararajan S, Wang L, Sridharan V, Chen W, Courtenay Luck N, Jones D, et al. Plasma membrane nucleolin is a receptor for the anticancer aptamer AS1411 in MV4-11 leukemia cells. Mol Pharmacol. 2009;76:984-91 pubmed publisher..These results provide evidence that plasma membrane nucleolin is a functional receptor for AS1411 in MV4-11 cells. ..
- Bhullar J, Sollars V. YBX1 expression and function in early hematopoiesis and leukemic cells. Immunogenetics. 2011;63:337-50 pubmed publisher..Thus, YBX1 protein could be an excellent molecular target for therapy in myeloproliferative disorders and leukemia. ..
- Butler B, Blystone S. Tyrosine phosphorylation of beta3 integrin provides a binding site for Pyk2. J Biol Chem. 2005;280:14556-62 pubmed..These data identify Pyk2 as a phosphorylated beta(3) binding partner, providing a potential structural and signaling platform to achieve alpha(V)beta(3) -mediated remodeling of the actin cytoskeleton. ..
- Avva J, Weis M, Sramkoski R, SREENATH S, Jacobberger J. Dynamic expression profiles from static cytometry data: component fitting and conversion to relative, "same scale" values. PLoS ONE. 2012;7:e38275 pubmed publisher..These expression profiles are the "state variable" outputs, useful for calibrating mathematical cell cycle models. ..
- Judge C, Reyes Aviles E, Conry S, Sieg S, Feng Z, Weinberg A, et al. HBD-3 induces NK cell activation, IFN-γ secretion and mDC dependent cytolytic function. Cell Immunol. 2015;297:61-8 pubmed publisher..HBD-3 may therefore act as a mediator of innate cell interactions that result in bridging of innate and adaptive immunity. ..
- Darst R, Pardo C, Pondugula S, Gangaraju V, Nabilsi N, Bartholomew B, et al. Simultaneous single-molecule detection of endogenous C-5 DNA methylation and chromatin accessibility using MAPit. Methods Mol Biol. 2012;833:125-41 pubmed publisher..CviPI). We term this technique MAPit, methylation accessibility protocol for individual templates. ..
- Lan X, Witt H, Katsumura K, Ye Z, Wang Q, Bresnick E, et al. Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages. Nucleic Acids Res. 2012;40:7690-704 pubmed..Our work, in combination with previous studies linking regulation by GATA factors with c-Jun and BRG1, provides genome-wide evidence that Hi-C data identify sets of biologically relevant interacting loci...
- Kurokawa M, Ito T, Yang C, Zhao C, Macintyre A, Rizzieri D, et al. Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. Proc Natl Acad Sci U S A. 2013;110:2300-5 pubmed publisher..Because we harness, rather than inhibit, the activity of leukemogenic kinases to kill transformed cells, this approach selectively eliminates leukemic cells regardless of drug-resistant mutations. ..
- Gaither L, Eide D. The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. J Biol Chem. 2001;276:22258-64 pubmed..The observation that hZIP1 is the major zinc transporter in K562 cells, coupled with its expression in many normal cell types, indicates that hZIP1 plays an important role in zinc uptake in human tissues. ..
- Pandya K, Townes T. Basic residues within the Kruppel zinc finger DNA binding domains are the critical nuclear localization determinants of EKLF/KLF-1. J Biol Chem. 2002;277:16304-12 pubmed..The basic residues of all mammalian Kruppel zinc fingers are highly conserved; therefore we propose that these basic residues are a common NLS shared by all Kruppel family members. ..
- Treff N, Su J, Taylor D, Scott R. Telomere DNA deficiency is associated with development of human embryonic aneuploidy. PLoS Genet. 2011;7:e1002161 pubmed publisher..Heterogeneity in telomere length within oocytes may provide an opportunity to improve the treatment of infertility through telomere-based selection of oocytes and embryos with reproductive competence. ..
- Chang J, Santhanam R, Trotta R, Neviani P, Eiring A, Briercheck E, et al. High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBPalpha-driven myeloid differentiation. Blood. 2007;110:994-1003 pubmed..Furthermore, these findings suggest the inclusion of clinically relevant MAPK inhibitors in the therapy of CML-BC. ..
- Rauen M, Burtelow M, Dufault V, Karnitz L. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. J Biol Chem. 2000;275:29767-71 pubmed..Collectively, these data provide the first experimental evidence that hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9 in manner similar to the interaction between RFC and PCNA. ..
- Singhal S, Singhal J, Sharma R, Singh S, Zimniak P, Awasthi Y, et al. Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. Int J Oncol. 2003;22:365-75 pubmed..Taken together, these findings suggest that RLIP76 activity is a general determinant of 4HNE and DOX resistance, and that its activity contributes to the drug-resistant phenotype of NSCLC...
- Prince T, Shao J, Matts R, Hartson S. Evidence for chaperone heterocomplexes containing both Hsp90 and VCP. Biochem Biophys Res Commun. 2005;331:1331-7 pubmed..Functional characterizations indicate that VCP is not an Hsp90 substrate, but rather demonstrate the biochemical hallmarks of an Hsp90 co-chaperone. Potential roles for a collaboration between for Hsp90 and VCP are discussed. ..
- Walters D, Mercher T, Gu T, O Hare T, Tyner J, Loriaux M, et al. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 2006;10:65-75 pubmed..These findings illustrate the biological importance of gain-of-function JAK3 mutations in leukemogenesis and demonstrate the utility of proteomic approaches to identifying clinically relevant mutations...
- Eiring A, Neviani P, Santhanam R, Oaks J, Chang J, Notari M, et al. Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. Blood. 2008;111:816-28 pubmed..Thus, the complexity of the mRNA/RBP network, together with the discovery of E2F3 as an hnRNP-A1-regulated factor, outlines the relevant role played by RBPs in posttranscriptional regulation of CML development and progression. ..
- Crusselle Davis V, Zhou Z, Anantharaman A, Moghimi B, Dodev T, Huang S, et al. Recruitment of coregulator complexes to the beta-globin gene locus by TFII-I and upstream stimulatory factor. FEBS J. 2007;274:6065-73 pubmed
- Polireddy K, Khan M, Chavan H, Young S, Ma X, Waller A, et al. A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6. PLoS ONE. 2012;7:e40005 pubmed publisher..Application of this assay to other libraries of synthetic compounds and natural products is expected to identify novel modulators of ABCB6 activity...
- Beverly L, Howell L, Hernandez Corbacho M, Casson L, Chipuk J, Siskind L. BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins. Biochem J. 2013;452:111-9 pubmed publisher..Furthermore, we present a feed-forward model by which BAK activation of CerS by chemotherapeutic drugs leads to elevated ceramide levels that result in synergistic channel formation by ceramide (or one of its metabolites) and BAX/BAK. ..
- Jin S, Su H, Tran N, Song J, Lu S, Li Y, et al. Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1. PLoS ONE. 2017;12:e0175523 pubmed publisher..Therefore, mutations of SF3B1 may block erythropoiesis via dysregulation of alternative RNA splicing of transcription factor TAL1, and targeting PRMT1 may alleviate the anemic symptoms in MDS patients. ..
- Gaither L, Eide D. Functional expression of the human hZIP2 zinc transporter. J Biol Chem. 2000;275:5560-4 pubmed..Finally, hZip2 was exclusively localized in the plasma membrane. These results indicate that hZip2 is a zinc transporter, and its identification provides one of the first molecular tools to study zinc uptake in mammalian cells. ..
- Duan Z, Stamatoyannopoulos G, Li Q. Role of NF-Y in in vivo regulation of the gamma-globin gene. Mol Cell Biol. 2001;21:3083-95 pubmed..These findings suggest that recruitment of NF-Y to the duplicated CCAAT box plays a role in the chromatin opening of the gamma gene promoter as well as in the communication between the gamma gene promoter and the LCR. ..
- Leclerc G, Barredo J. Folylpoly-gamma-glutamate synthetase gene mRNA splice variants and protein expression in primary human leukemia cells, cell lines, and normal human tissues. Clin Cancer Res. 2001;7:942-51 pubmed..However, its role in regulating the expression of its mRNA remains to be determined. ..
- Shao J, Prince T, Hartson S, Matts R. Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37. J Biol Chem. 2003;278:38117-20 pubmed..Thus, the data indicate that phosphorylation of Cdc37 on Ser13 is critical for its ability to coordinate Hsp90 nucleotide-mediated conformational switching and kinase binding. ..
- Gustafson W, Ray S, Jamieson L, Thompson E, Brasier A, Fields A. Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter. J Biol Chem. 2004;279:9400-8 pubmed..Our results indicate that Bcr-Abl-mediated transformation involves transcriptional activation of the PKCiota gene, which in turn is required for Bcr-Abl-mediated chemoresistance. ..
- Xing H, Mayhew C, Cullen K, Park Sarge O, Sarge K. HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. J Biol Chem. 2004;279:10551-5 pubmed..Thus, HSF1 regulates HSP gene expression at not one but two different steps of the expression pathway, functioning both as a transcription factor and a polyadenylation stimulatory factor. ..
- Vieira K, Levings P, Hill M, Crusselle V, Kang S, Engel J, et al. Recruitment of transcription complexes to the beta-globin gene locus in vivo and in vitro. J Biol Chem. 2004;279:50350-7 pubmed..The data are consistent with the hypothesis that the LCR serves as the primary attachment site for the recruitment of macromolecular complexes involved in chromatin structure alterations and transcription of the globin genes. ..
- Prince T, Sun L, Matts R. Cdk2: a genuine protein kinase client of Hsp90 and Cdc37. Biochemistry. 2005;44:15287-95 pubmed
- Hu X, Yang D, Zimmerman M, Liu F, Yang J, Kannan S, et al. IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia. Cancer Res. 2011;71:2882-91 pubmed publisher..In summary, our findings determine the mechanism of IRF8 downregulation in CML cells and they determine a primary pathway of resistance to Fas-mediated apoptosis and disease progression. ..
- Liu Y, Patwardhan G, Xie P, Gu X, Giuliano A, Cabot M. Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma. Int J Oncol. 2011;39:425-31 pubmed publisher..Although a small study, these data suggest that GCS may be a prognostic indicator and potential target for the treatment of chemotherapy-refractory breast cancer. ..
- Wang Y, Langer N, Shaw G, Yang G, Li L, Kaplan J, et al. Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria. Exp Hematol. 2011;39:784-94 pubmed publisher..Abnormal MFRN1 expression can contribute to erythropoietic protoporphyria phenotype in some patients, probably by causing a reduction in FECH activity. ..
- Murray S, Nesterenko P, Vanarsdall A, Munks M, Smart S, Veziroglu E, et al. Fibroblast-adapted human CMV vaccines elicit predominantly conventional CD8 T cell responses in humans. J Exp Med. 2017;214:1889-1899 pubmed publisher..These results indicate that fibroblast adaptation alone is unlikely to explain the unconventional responses observed in macaques. ..
- Cao Q, Anyansi C, Hu X, Xu L, Xiong L, Tang W, et al. Reconstruction of enhancer-target networks in 935 samples of human primary cells, tissues and cell lines. Nat Genet. 2017;49:1428-1436 pubmed publisher..We also identify differentially methylated enhancers in hepatocellular carcinoma (HCC) and experimentally confirm their altered regulation of HCC-related genes. ..
- Johnson M, Enns C. Diferric transferrin regulates transferrin receptor 2 protein stability. Blood. 2004;104:4287-93 pubmed..Our results support a role for TfR2 in monitoring iron levels by sensing changes in the concentration of diferric Tf. ..
- Zhang Y, Biggs J, Kraft A. Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation. J Biol Chem. 2004;279:53116-25 pubmed..Inhibitor assays suggest that the ERK family of protein kinases is activated by PEs to phosphorylate the (S/T)P sites within the AML1c molecule and markedly enhance the transcriptional activity of AML1c. ..
- Gao C, Schaefer E, Lakkis M, Blystone S. Beta3 tyrosine phosphorylation and alphavbeta3-mediated adhesion are required for Vav1 association and Rho activation in leukocytes. J Biol Chem. 2005;280:15422-9 pubmed..These studies describe a phosphorylation-dependent association between beta(3) integrin and Vav1 which is essential for cell progression to a Rho-dominant phenotype during cell adhesion. ..
- Olabisi O, Mahon G, Kostenko E, Liu Z, Ozer H, Whitehead I. Bcr interacts with components of the endosomal sorting complex required for transport-I and is required for epidermal growth factor receptor turnover. Cancer Res. 2006;66:6250-7 pubmed..Taken together, these observations suggest that Bcr is a component of the mammalian ESCRT complexes and plays an important role in cellular trafficking of growth factor receptors. ..
- Greenberg M, Sun M, Zhang R, Febbraio M, Silverstein R, Hazen S. Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells. J Exp Med. 2006;203:2613-25 pubmed..Collectively, these results identify oxPS-CD36 interactions on macrophages as potential participants in a broad range of physiologic processes where macrophage-mediated engulfment of apoptotic cells is involved. ..
- Lurie L, Boyer M, Grass J, Bresnick E. Differential GATA factor stabilities: implications for chromatin occupancy by structurally similar transcription factors. Biochemistry. 2008;47:859-69 pubmed
- Ahn S, Duke C, Barrett C, Hwang D, Li C, Miller D, et al. I-387, a novel antimitotic indole, displays a potent in vitro and in vivo antitumor activity with less neurotoxicity. Mol Cancer Ther. 2010;9:2859-68 pubmed publisher..The potent in vitro and in vivo antitumor activity of I-387 suggests that it may represent a new antimitotic agent for management of various malignancies, particularly for patients with drug-resistant cancer. ..
- Motiwala T, Zanesi N, Datta J, Roy S, Kutay H, Checovich A, et al. AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia. Blood. 2011;118:6132-40 pubmed publisher..Finally, using primary CLL cells we have shown an inverse relationship between TCL1 and PTPROt expression. These findings further substantiate the role of TCL1 in PTPROt suppression and its importance in the pathogenesis of CLL. ..
- Chini C, Chen J. Human claspin is required for replication checkpoint control. J Biol Chem. 2003;278:30057-62 pubmed..Taken together, these data imply a potentially critical role for Claspin in replication checkpoint control in mammalian cells. ..
- Meng X, Lee S, Dai H, Loegering D, Yu C, Flatten K, et al. Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization. J Biol Chem. 2007;282:29831-46 pubmed..Collectively, these observations not only suggest a model in which Mcl-1 confers TRAIL resistance by serving as a buffer for Bak, Bim, and Puma, but also identify sorafenib as a potential modulator of TRAIL sensitivity...
- Pluskota E, Soloviev D, Szpak D, Weber C, Plow E. Neutrophil apoptosis: selective regulation by different ligands of integrin alphaMbeta2. J Immunol. 2008;181:3609-19 pubmed..Hence, engagement of a single integrin by closely related ligands can induce distinct signaling pathways, which can elicit distinct cellular responses. ..
- Benson D, Bakan C, Mishra A, Hofmeister C, Efebera Y, Becknell B, et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. Blood. 2010;116:2286-94 pubmed publisher..A phase 2 clinical trial of CT-011 in combination with lenalidomide for patients with MM should be considered. ..
- Advani A, Shadman M, Ali Osman F, Barker A, Rybicki L, Kalaycio M, et al. A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse. Clin Lymphoma Myeloma Leuk. 2010;10:473-6 pubmed publisher..The high expression of GSTP1 suggests that this may be a therapeutic target for relapsed AML. Finally, the rapidity and ease of using RT-PCR to quantify MDR in this study may have clinical utility in future trials. ..
- Barnes J, Warejcka D, Simpliciano J, TWINING S, Steet R. Latency-associated peptide of transforming growth factor-?1 is not subject to physiological mannose phosphorylation. J Biol Chem. 2012;287:7526-34 pubmed publisher..Collectively, these findings indicate that Man-6-P-dependent effects on latent TGF-?1 activation are not mediated by direct modification of its latency-associated peptide. ..
- Ceribelli A, Fredi M, Taraborelli M, Cavazzana I, Franceschini F, Quinzanini M, et al. Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis. Arthritis Res Ther. 2012;14:R97 pubmed publisher..Anti-MJ antibodies, which recognize the nuclear protein NXP-2/MORC3, are reported in ~25% of juvenile DM. Prevalence and clinical significance of anti-MJ antibodies in adult Italian PM/DM patients were studied...
- Hackanson B, Bennett K, Brena R, Jiang J, Claus R, Chen S, et al. Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia. Cancer Res. 2008;68:3142-51 pubmed publisher..Our results indicate that epigenetic alterations of C/EBP alpha are a frequent event in AML and that epigenetic treatment can result in down-regulation of a key hematopoietic transcription factor. ..
- Frisa P, Jacobberger J. Cell cycle-related cyclin b1 quantification. PLoS ONE. 2009;4:e7064 pubmed publisher..This suggests tight quantitative end point control. ..
- Cunningham E. An inositolphosphate-binding immunophilin, IPBP12. Blood. 1999;94:2778-89 pubmed..The latter is indicated to be phosphoprotein phosphatase 2A (PP-2A). It is suggested that immunophilins promote the assembly of multiprotein complexes that often include a protein kinase or a phosphoprotein phosphatase or both. ..
- Fair K, Anderson M, Bulanova E, Mi H, Tropschug M, Diaz M. Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells. Mol Cell Biol. 2001;21:3589-97 pubmed..These results suggest that binding of Cyp33 to MLL modulates its effects on the expression of target genes. ..
- Burtelow M, Roos Mattjus P, Rauen M, Babendure J, Karnitz L. Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex. J Biol Chem. 2001;276:25903-9 pubmed..Collectively, these analyses suggest a model of how these three proteins assemble to form a functional checkpoint complex, which we dubbed the 9-1-1 complex. ..
- Yamane K, Wu X, Chen J. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol. 2002;22:555-66 pubmed..Taken together, the data presented here suggest that, like its putative counterparts in yeast species, TopBP1 may be involved in DNA damage and replication checkpoint controls. ..
- Roos Mattjus P, Vroman B, Burtelow M, Rauen M, Eapen A, Karnitz L. Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event. J Biol Chem. 2002;277:43809-12 pubmed..Collectively, these studies demonstrate that 9-1-1 chromatin binding is a proximal event in the checkpoint signaling cascade. ..