Experts and Doctors on ions in Israel


Locale: Israel
Topic: ions

Top Publications

  1. Cohen E, Goldshleger R, Shainskaya A, Tal D, Ebel C, le Maire M, et al. Purification of Na+,K+-ATPase expressed in Pichia pastoris reveals an essential role of phospholipid-protein interactions. J Biol Chem. 2005;280:16610-8 pubmed
    ..Purified recombinant Na+,K+-ATPase could become an important experimental tool for various purposes, including, hopefully, structural work. ..
  2. Friedman R, Nachliel E, Gutman M. Molecular dynamics of a protein surface: ion-residues interactions. Biophys J. 2005;89:768-81 pubmed
    ..The similarity between the motion of free ions next to a protein and the proton transfer on the protein's surface are discussed. ..
  3. Kapishnikov S, Weiner A, Shimoni E, Guttmann P, Schneider G, Dahan Pasternak N, et al. Oriented nucleation of hemozoin at the digestive vacuole membrane in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2012;109:11188-93 pubmed publisher
    ..Their analysis supports a model of hemozoin nucleation primarily in the DV. Modeling of the contrast at the DV membrane indicates a 4-nm thickness with patches about three times thicker, possibly implicated in the nucleation. ..
  4. Feine I, Pinkas I, Salomon Y, Scherz A. Local oxidative stress expansion through endothelial cells--a key role for gap junction intercellular communication. PLoS ONE. 2012;7:e41633 pubmed publisher
    ..Localized oxidative insults propagate through GJIC between ECs, while stimulating de-novo generation of ROS and RNS in bystander cells, thereby driving the insult's expansion. ..
  5. Katz A, Lifshitz Y, Bab Dinitz E, Kapri Pardes E, Goldshleger R, Tal D, et al. Selectivity of digitalis glycosides for isoforms of human Na,K-ATPase. J Biol Chem. 2010;285:19582-92 pubmed publisher
    ..In conclusion, several digitalis glycosides, but not ouabain, are moderately alpha2-selective. This supports a major role of alpha2 in cardiac contraction and cardiotonic effects of digitalis glycosides. ..
  6. Tawfik D, Viola R. Arsenate replacing phosphate: alternative life chemistries and ion promiscuity. Biochemistry. 2011;50:1128-34 pubmed publisher
    ..Finally, we highlight potential applications of arsenate as a structural and mechanistic probe of enzymes whose catalyzed reactions involve the making or breaking of phosphoester bonds. ..
  7. Faingold A, Cohen S, Wagner H. Nanoindentation of osteonal bone lamellae. J Mech Behav Biomed Mater. 2012;9:198-206 pubmed publisher
    ..Finally, based on the experimentally measured Young's modulus values, most osteonal lamellae appear to exhibit structural anisotropy. ..
  8. Erez O, Kahana C. Screening for modulators of spermine tolerance identifies Sky1, the SR protein kinase of Saccharomyces cerevisiae, as a regulator of polyamine transport and ion homeostasis. Mol Cell Biol. 2001;21:175-84 pubmed
    ..While deletion or overexpression of SKY1 did not significantly affect Pma1p activity, the ability of overexpressed Sky1p, Ptk1p, and Ptk2p to increase sensitivity to LiCl depends on the integrity of PPZ1 but not of ENA1. ..
  9. Frenkiel Krispin D, Levin Zaidman S, Shimoni E, Wolf S, Wachtel E, Arad T, et al. Regulated phase transitions of bacterial chromatin: a non-enzymatic pathway for generic DNA protection. EMBO J. 2001;20:1184-91 pubmed

More Information


  1. Erez O, Kahana C. Deletions of SKY1 or PTK2 in the Saccharomyces cerevisiae trk1Deltatrk2Delta mutant cells exert dual effect on ion homeostasis. Biochem Biophys Res Commun. 2002;295:1142-9 pubmed
    ..A model that integrates these results to explain the mechanism of ion transport across the plasma membrane is proposed. ..
  2. Opatowsky Y, Chomsky Hecht O, Kang M, Campbell K, Hirsch J. The voltage-dependent calcium channel beta subunit contains two stable interacting domains. J Biol Chem. 2003;278:52323-32 pubmed
    ..Domain II is responsible for this binding, but domain I enhances it. ..
  3. Soskine M, Adam Y, Schuldiner S. Direct evidence for substrate-induced proton release in detergent-solubilized EmrE, a multidrug transporter. J Biol Chem. 2004;279:9951-5 pubmed
    ..5 and for an aspartate replacement at the same position as 6.7. The high pK of the carboxyl at position 14 is essential for coupling of fluxes of protons and substrates. ..
  4. Katz B, Minke B. Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors. J Neurosci. 2012;32:2722-33 pubmed publisher
    ..We thus demonstrate how a G-protein-mediated transduction system, with PLC as its target, selectively suppresses its intrinsic noise while preserving reliable signaling. ..
  5. Cohen L, Asraf H, Sekler I, Hershfinkel M. Extracellular pH regulates zinc signaling via an Asp residue of the zinc-sensing receptor (ZnR/GPR39). J Biol Chem. 2012;287:33339-50 pubmed
    ..In conclusion, ZnR/GPR39 is tuned to sense physiologically relevant changes in extracellular pH that thus regulate ZnR-dependent signaling and ion transport activity. ..
  6. Distler U, Kuharev J, Navarro P, Levin Y, Schild H, Tenzer S. Drift time-specific collision energies enable deep-coverage data-independent acquisition proteomics. Nat Methods. 2014;11:167-70 pubmed publisher
    ..Additionally, we report a software tool, ISOQuant, for processing label-free quantitative UDMS(E) data. ..