Genomes and Genes
Experts and Doctors on intestines in United States
Locale: United States
Publications332 found, 100 shown here
- Neu J, Lorca G, Kingma S, Triplett E. The intestinal microbiome: relationship to type 1 diabetes. Endocrinol Metab Clin North Am. 2010;39:563-71 pubmed publisher..It attempts to identify avenues that should be pursued that relate this new evidence to interventions that eventually could result in prevention. ..
- Zhang Y, Limaye P, Lehman McKeeman L, Klaassen C. Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. PLoS ONE. 2012;7:e34522 pubmed publisher..In conclusion, the present study for the first time established that lack of a liver transporter (Oatp1a1) markedly alters the intestinal environment in mice, namely the bacteria composition. ..
- Mukherjee S, Zheng H, DEREBE M, Callenberg K, Partch C, Rollins D, et al. Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature. 2014;505:103-7 pubmed publisher..Our findings identify C-type lectins as mediators of membrane attack in the mucosal immune system, and provide detailed insight into an antibacterial mechanism that promotes mutualism with the resident microbiota. ..
- Kundrapu S, Sunkesula V, Jury L, Cadnum J, Nerandzic M, Musuuza J, et al. Do piperacillin/tazobactam and other antibiotics with inhibitory activity against Clostridium difficile reduce the risk for acquisition of C. difficile colonization?. BMC Infect Dis. 2016;16:159 pubmed publisher..Our findings suggest that piperacillin/tazobactam achieves sufficient concentrations in the intestinal tract to inhibit C. difficile colonization during therapy. ..
- Krautkramer K, Rey F, Denu J. Chemical signaling between gut microbiota and host chromatin: What is your gut really saying?. J Biol Chem. 2017;292:8582-8593 pubmed publisher..This review focuses on eukaryotic chromatin regulation by endogenous and gut microbial metabolites and how these regulatory events may impact host developmental and metabolic phenotypes. ..
- Nankervis C, Dunaway D, Miller C. Endothelin ET(A) and ET(B) receptors in postnatal intestine. Am J Physiol Gastrointest Liver Physiol. 2001;280:G555-62 pubmed..These results suggest that both ET receptor populations are expressed to a greater degree in younger animals and I/R significantly affects the ET(B) receptor...
- Ten Hagen K, Bedi G, Tetaert D, Kingsley P, Hagen F, Balys M, et al. Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9. J Biol Chem. 2001;276:17395-404 pubmed..These findings lend further support to the existence of a hierarchical network of differential enzymatic activity within the diversely regulated ppGaNTase family, which may play a role in the various processes governing development. ..
- Klett E, Lu K, Kosters A, Vink E, Lee M, Altenburg M, et al. A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med. 2004;2:5 pubmed..No phenotypic difference has yet been described in humans with complete defects in either ABCG5 or ABCG8. These proteins, based upon the defects in humans, are responsible for regulating dietary sterol entry and biliary sterol secretion...
- Pultz N, Stiefel U, Donskey C. Effects of daptomycin, linezolid, and vancomycin on establishment of intestinal colonization with vancomycin-resistant enterococci and extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae in mice. Antimicrob Agents Chemother. 2005;49:3513-6 pubmed..However, the effects varied depending on dose and duration of treatment. Daptomycin treatment did not disrupt the anaerobic microflora or promote either pathogen. ..
- Necela B, Su W, Thompson E. Peroxisome proliferator-activated receptor gamma down-regulates follistatin in intestinal epithelial cells through SP1. J Biol Chem. 2008;283:29784-94 pubmed publisher..Collectively, our data indicate that repression of Sp1 transcriptional activity by PPARgamma is the underlying mechanism responsible for PPARgamma-mediated regulation of follistatin expression. ..
- Davies P, Dismuke A, Powell A, Carroll K, Wong M. Wnt-reporter expression pattern in the mouse intestine during homeostasis. BMC Gastroenterol. 2008;8:57 pubmed publisher..Our findings have an important impact on understanding the regulation of the intestinal stem cell hierarchy during homeostasis and in disease states. ..
- Nerandzic M, Pultz M, Donskey C. Examination of potential mechanisms to explain the association between proton pump inhibitors and Clostridium difficile infection. Antimicrob Agents Chemother. 2009;53:4133-7 pubmed publisher..Our results suggest that the effects of PPIs in the stomach do not contribute to the pathogenesis of CDI...
- Deitch E. Gut lymph and lymphatics: a source of factors leading to organ injury and dysfunction. Ann N Y Acad Sci. 2010;1207 Suppl 1:E103-11 pubmed publisher..Second, this hypothesis provides new pathophysiologic information, thereby providing a basis for novel therapies. Finally, by studying the composition of lymph, MODS-inducing factors can be isolated and identified. ..
- Parthasarathy R, Lakshmanan J, Thangavel M, Seelan R, Stagner J, Janckila A, et al. Rat brain myo-inositol 3-phosphate synthase is a phosphoprotein. Mol Cell Biochem. 2013;378:83-9 pubmed publisher..These observations suggest a novel function for IPS in brain and other tissues. Future studies should resolve the functional role of phospho-IPS in brain inositol signaling. ..
- Wang H, Brown J, Gao S, Liang S, Jotwani R, Zhou H, et al. The role of JAK-3 in regulating TLR-mediated inflammatory cytokine production in innate immune cells. J Immunol. 2013;191:1164-74 pubmed publisher..These findings demonstrate the negative regulatory function of JAK3 and elucidate the signaling pathway by which JAK3 differentially regulates TLR-mediated inflammatory cytokine production in innate immune cells. ..
- Gulec S, Collins J. Silencing the Menkes copper-transporting ATPase (Atp7a) gene in rat intestinal epithelial (IEC-6) cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1). J Nutr. 2014;144:12-9 pubmed publisher..Alterations in copper transport, trafficking, or distribution may underlie the increase in transepithelial iron flux noted when ATP7A activity is diminished. ..
- Choi H, Broitman Maduro G, Maduro M. Partially compromised specification causes stochastic effects on gut development in C. elegans. Dev Biol. 2017;427:49-60 pubmed publisher..Hence, upstream perturbation of specification dramatically affects the E lineage, but as long as sufficient descendants adopt a gut fate, organogenesis overcomes these effects to form a relatively normal intestine. ..
- Harokopakis E, Hajishengallis G, Michalek S. Effectiveness of liposomes possessing surface-linked recombinant B subunit of cholera toxin as an oral antigen delivery system. Infect Immun. 1998;66:4299-304 pubmed..This oral immunization strategy should be applicable for the development of vaccines against oral, intestinal, or sexually transmitted diseases. ..
- Dufner Beattie J, Langmade S, Wang F, Eide D, Andrews G. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J Biol Chem. 2003;278:50142-50 pubmed..These studies suggest that all three of these ZIP proteins may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc. ..
- Pope M, Hoffman S, Tomlinson S, Fleming S. Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion. Mol Immunol. 2010;48:356-64 pubmed publisher..These data indicate that TLR4 regulates extrahepatic complement production while complement regulates TLR4-mediated cytokine production during intestinal IR. ..
- Wang X, Hardwidge P. Enterotoxigenic Escherichia coli prevents host NF-?B activation by targeting I?B? polyubiquitination. Infect Immun. 2012;80:4417-25 pubmed publisher..These data suggest that ETEC evades the host innate immune response by directly modulating NF-?B signaling. ..
- Lee K, Dabrowski K. Gossypol and gossypolone enantiomers in tissues of rainbow trout fed low and high levels of dietary cottonseed meal. J Agric Food Chem. 2002;50:3056-61 pubmed
- Zakaria E, Hurt R, Matheson P, Garrison R. A novel method of peritoneal resuscitation improves organ perfusion after hemorrhagic shock. Am J Surg. 2003;186:443-8 pubmed..Direct peritoneal resuscitation enhanced blood flow to organs incited in the pathogenesis of multiple organ failure that follows hemorrhagic shock. ..
- Pahar B, Lackner A, Veazey R. Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines. Eur J Immunol. 2006;36:583-92 pubmed..Finally, these intestinal DP T cells may be important target cells for HIV infection and replication due to their activation, memory phenotype and high expression of CCR5. ..
- Geiser J, Venken K, De Lisle R, Andrews G. A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. PLoS Genet. 2012;8:e1002766 pubmed publisher..These changes, in turn, cause a switch from anabolic to catabolic metabolism and altered homeostasis of several essential metals, which, if untreated by excess dietary zinc, leads to dramatic weight loss and death...
- Wang Y, Liu Y, Kirpich I, Ma Z, Wang C, Zhang M, et al. Lactobacillus rhamnosus GG reduces hepatic TNF? production and inflammation in chronic alcohol-induced liver injury. J Nutr Biochem. 2013;24:1609-15 pubmed publisher..In conclusion, probiotic LGG treatment reduced alcohol-induced hepatic inflammation by attenuation of TNF? production via inhibition of TLR4- and TLR5-mediated endotoxin activation. ..
- Picco M, Cangemi J. Inflammatory bowel disease in the elderly. Gastroenterol Clin North Am. 2009;38:447-62 pubmed publisher..Distinguishing these conditions from IBD will significantly alter prognosis and treatment. Complications related to IBD and its treatment are common and must be recognized early to limit their impact in a vulnerable elderly population. ..
- Shorokhov D, Zewail A. New light on molecular and materials complexity: 4D electron imaging. J Am Chem Soc. 2009;131:17998-8015 pubmed publisher..This contribution provides an expose of emerging developments and an outlook on future applications in materials and biological sciences. ..
- Wang D, Sadee W. CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing. Pharmacogenet Genomics. 2016;26:40-3 pubmed publisher..These results indicate that tissue-specific increased formation of nonfunctional alternative splice variant causes reduced CYP3A4 mRNA/protein expression in CYP3A4*22 carriers. ..
- Reber K, Nankervis C, Nowicki P. Newborn intestinal circulation. Physiology and pathophysiology. Clin Perinatol. 2002;29:23-39 pubmed
- Jenkins J, Courtney P. Lactobacillus growth and membrane composition in the presence of linoleic or conjugated linoleic acid. Can J Microbiol. 2003;49:51-7 pubmed..No association between level of fatty acid incorporation into the membrane and inhibition by that fatty acid was observed. ..
- Roy H, Iversen P, Hart J, Liu Y, Koetsier J, Kim Y, et al. Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension. Mol Cancer Ther. 2004;3:1159-65 pubmed..While this PMO regimen afforded modest SNAIL suppression and hence tumor reduction, this provides compelling evidence for the role of SNAIL overexpression in colonic neoplasia. ..
- Wang Y, Li J, Tang L, Wang Y, Charnigo R, de Villiers W, et al. T-lymphocyte responses to intestinally absorbed antigens can contribute to adipose tissue inflammation and glucose intolerance during high fat feeding. PLoS ONE. 2010;5:e13951 pubmed publisher..Our results suggest that loss or lack of immunological tolerance to intestinally absorbed T-lymphocyte antigens can contribute to mesenteric adipose tissue inflammation and defective glucose metabolism during high-fat dieting. ..
- Obi I, Sterling K, Ahearn G. Transepithelial D-glucose and D-fructose transport across the American lobster, Homarus americanus, intestine. J Exp Biol. 2011;214:2337-44 pubmed publisher..The transport of d-glucose and d-fructose across lobster intestine is similar to sugar uptake in mammalian intestine, suggesting evolutionarily conserved absorption processes for these solutes. ..
- Bhasin A, Chaston J, Goodrich Blair H. Mutational analyses reveal overall topology and functional regions of NilB, a bacterial outer membrane protein required for host association in a model of animal-microbe mutualism. J Bacteriol. 2012;194:1763-76 pubmed publisher..These findings are an important step in understanding the function of NilB and, by extension, its homologs in mucosal pathogens. ..
- Heuer J, Li K, Kaufman T. The Drosophila homeotic target gene centrosomin (cnn) encodes a novel centrosomal protein with leucine zippers and maps to a genomic region required for midgut morphogenesis. Development. 1995;121:3861-76 pubmed
- Pultz N, Stiefel U, Ghannoum M, Helfand M, Donskey C. Effect of parenteral antibiotic administration on establishment of intestinal colonization by Candida glabrata in adult mice. Antimicrob Agents Chemother. 2005;49:438-40 pubmed..These findings suggest that antibiotics that inhibit intestinal anaerobes promote C. glabrata colonization. ..
- Shapiro A, Green T, Rao S, White S, Carner G, Mertens P, et al. Morphological and molecular characterization of a Cypovirus (Reoviridae) from the mosquito Uranotaenia sapphirina (Diptera: Culicidae). J Virol. 2005;79:9430-8 pubmed..We conclude that UsCPV should be recognized as a member of a new Cypovirus species (Cypovirus 17, strain UsCPV-17)...
- Williams E, Carlson J, Lai W, Wong Y, Yoshimura T, Critchley D, et al. Investigation of the metabolism of rufinamide and its interaction with valproate. Drug Metab Lett. 2011;5:280-9 pubmed..Carboxylesterases were not significantly inhibited by CGP 47292. Inhibition of in vitro rufinamide hydrolysis by valproate could offer an explanation for the observed in vivo drug-drug interaction between the two antiepileptic drugs. ..
- Staley E, Yarbrough V, Schoeb T, Daft J, Tanner S, Steverson D, et al. Murine P-glycoprotein deficiency alters intestinal injury repair and blunts lipopolysaccharide-induced radioprotection. Radiat Res. 2012;178:207-16 pubmed
- Pope M, Bukovnik U, Tomich J, Fleming S. Small ?2-glycoprotein I peptides protect from intestinal ischemia reperfusion injury. J Immunol. 2012;189:5047-56 pubmed publisher..Thus, the ?2-glycoprotein I-derived peptides attenuate injury and inflammation when administered in a therapeutic manner in intestinal ischemia/reperfusion injury. ..
- Goudeau D, Parker C, Zhou Y, Sela S, Kroupitski Y, Brandl M. The salmonella transcriptome in lettuce and cilantro soft rot reveals a niche overlap with the animal host intestine. Appl Environ Microbiol. 2013;79:250-62 pubmed publisher..enterica to soft rot lesions, a common postharvest plant disease. ..
- Jones S, Paynich M, Kearns D, Knight K. Protection from intestinal inflammation by bacterial exopolysaccharides. J Immunol. 2014;192:4813-20 pubmed publisher..These studies provide a simple means of preventing intestinal inflammation caused by enteric pathogens. ..
- Strom M, Krisinger J, DeLuca H. Isolation of a mRNA that encodes a putative intestinal alkaline phosphatase regulated by 1,25-dihydroxyvitamin D-3. Biochim Biophys Acta. 1991;1090:299-304 pubmed..The corresponding mRNA is markedly increased by 6 h after a single dose of 1,25-dihydroxyvitamin D-3. The mRNA is also increased by 24-homologated analogs of 1,25-dihydroxyvitamin D-3 that do not increase calcium transport. ..
- Anderson P, Broderius M, Fong K, Tsui K, Chew S, Ip Y. Glutamine synthetase expression in liver, muscle, stomach and intestine of Bostrichthys sinensis in response to exposure to a high exogenous ammonia concentration. J Exp Biol. 2002;205:2053-65 pubmed
- Teng X, Cutler D, Davies N. Mometasone furoate degradation and metabolism in human biological fluids and tissues. Biopharm Drug Dispos. 2003;24:321-33 pubmed
- James M, Lou Z, Rowland Faux L, Celander M. Properties and regional expression of a CYP3A-like protein in channel catfish intestine. Aquat Toxicol. 2005;72:361-71 pubmed..77 pmol/min/mg protein, mean +/- S.D., n = 5 and 1.45 +/- 0.42 in these respective segments. The results of this study strongly suggest that CYP3A is important in the first pass metabolism of dietary xenobiotics in untreated fish. ..
- Matsler P, Chapman H. Characterization of a strain of Eimeria meleagridis from the turkey. Avian Dis. 2006;50:599-604 pubmed..An inoculum of 2 X 10(5) oocysts was found to cause a significant reduction in weight gain from days 0-3 and 0-6 after infection, suggesting that the significance of this species of Eimeria as a pathogen of turkeys should be reassessed. ..
- Wolff B, Viscusi E, Delaney C, Du W, Techner L. Patterns of gastrointestinal recovery after bowel resection and total abdominal hysterectomy: pooled results from the placebo arms of alvimopan phase III North American clinical trials. J Am Coll Surg. 2007;205:43-51 pubmed..This analysis provides important clinical insight into the differences in GI recovery patterns and the incidence and impact of POI after BR and TAH. ..
- Firstenberg M, Sai Sudhakar C, Sirak J, Crestanello J, Sun B. Intestinal ischemia complicating ascending aortic dissection: first things first. Ann Thorac Surg. 2007;84:e8-9 pubmed..We present a case of acute ascending aortic dissection associated with an intra-abdominal vascular and enteric catastrophe that was successfully managed prior to aortic repair...
- Stevenson R, Rogers R, Chandler J, Gauderer M, Hunter A. Escape of the yolk sac: a hypothesis to explain the embryogenesis of gastroschisis. Clin Genet. 2009;75:326-33 pubmed publisher..This connection through the ventral wall prevents normal egress of the gut into the umbilical cord during the second month of development and acts as the egress point for the gut resulting in gastroschisis...
- Radulescu A, Zhang H, Chen C, Chen Y, Zhou Y, Yu X, et al. Heparin-binding EGF-like growth factor promotes intestinal anastomotic healing. J Surg Res. 2011;171:540-50 pubmed publisher..WT mice that received HB-EGF had increased bursting pressures compared with non-HB-EGF treated mice. Our results demonstrate that HB-EGF is an important factor involved in the healing of intestinal anastomoses. ..
- Khajuria C, Buschman L, Chen M, Siegfried B, Zhu K. Identification of a novel aminopeptidase P-like gene (OnAPP) possibly involved in Bt toxicity and resistance in a major corn pest (Ostrinia nubilalis). PLoS ONE. 2011;6:e23983 pubmed publisher..These results strongly suggest that the OnAPP gene could be involved in binding the Cry1Ab toxin in the ECB larval midgut and that mutations in this gene may be associated with Bt resistance in these two ECB strains. ..
- Yu T, Chen X, Zhang W, Li J, Xu R, Wang T, et al. Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. PLoS ONE. 2012;7:e32492 pubmed publisher..These findings suggest that, as a tumor suppressor in colorectal cancer, KLF4 affects intestinal epithelial cell morphology by regulating proliferation, differentiation and polarity of the cells. ..
- Chen C, Fang R, Chou L, Lowe A, Sibley E. PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells. Biochem Biophys Res Commun. 2012;423:183-7 pubmed publisher..PDX1 repression of FABP1, LCT, and SI suggests a role for PDX1 in patterning anterior intestinal development. ..
- Kakiyama G, Pandak W, Gillevet P, Hylemon P, Heuman D, Daita K, et al. Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. J Hepatol. 2013;58:949-55 pubmed publisher..Cirrhosis, especially advanced disease, is associated with a decreased conversion of primary to secondary fecal BAs, which is linked to abundance of key gut microbiome taxa. ..
- Bowerman B, Eaton B, Priess J. skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo. Cell. 1992;68:1061-75 pubmed..We propose that the maternally expressed skn-1 gene product acts to specify the fate of the EMS blastomere. ..
- Nemere I, Leathers V, Thompson B, Luben R, Norman A. Redistribution of calbindin-D28k in chick intestine in response to calcium transport. Endocrinology. 1991;129:2972-84 pubmed..Additionally, calbindin-D28K is dynamically involved in Ca2+ transport in the intestine. ..
- McClave S, Chang W. Complications of enteral access. Gastrointest Endosc. 2003;58:739-51 pubmed
- Cornelius J, Peck A. Colonization of the neonatal rat intestinal tract from environmental exposure to the anaerobic bacterium Oxalobacter formigenes. J Med Microbiol. 2004;53:249-54 pubmed..formigenes strain of the foster mothers. These data indicate that intestinal colonization occurs horizontally, but does not answer the question of how O. formigenes survives the aerobic environment in order to be transmitted...
- Haigis K, Hoff P, White A, Shoemaker A, Halberg R, Dove W. Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. Proc Natl Acad Sci U S A. 2004;101:9769-73 pubmed..Perhaps, the power of mouse genetics and biology can be harnessed to identify genetic and other factors that contribute to tumor regionality. ..
- McClave S, Lukan J, Stefater J, Lowen C, Looney S, Matheson P, et al. Poor validity of residual volumes as a marker for risk of aspiration in critically ill patients. Crit Care Med. 2005;33:324-30 pubmed..No appropriate designated RV level to identify aspiration could be derived as a result of poor sensitivity over a wide range of RV. Study results do not support the conventional use of RV as a marker for the risk of aspiration. ..
- You S, Ohmori M, Pena M, Nassri B, Quiton J, Al Assad Z, et al. Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. Int J Exp Pathol. 2006;87:227-36 pubmed
- Slitt A, Allen K, Morrone J, Aleksunes L, Chen C, Maher J, et al. Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochim Biophys Acta. 2007;1768:637-47 pubmed
- Sharma R, Tepas J, Hudak M, Mollitt D, Wludyka P, Teng R, et al. Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis. J Pediatr Surg. 2007;42:454-61 pubmed..Endotoxemia was most severe at the onset of illness among the infants with NEC, suggesting that gut barrier failure plays an important role in adverse outcomes in the NICU. ..
- Douglass T, Driggers L, Zhang J, Hoa N, Delgado C, Williams C, et al. Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies. Int Immunopharmacol. 2008;8:1354-76 pubmed publisher..Recent experiments suggest that a tumor vaccine based on membrane-bound M-CSF-transduced tumor cells, combined with anti-angiogenic therapy, should be evaluated further for use in clinical trials. ..
- Kutuzova G, Sundersingh F, Vaughan J, Tadi B, Ansay S, Christakos S, et al. TRPV6 is not required for 1alpha,25-dihydroxyvitamin D3-induced intestinal calcium absorption in vivo. Proc Natl Acad Sci U S A. 2008;105:19655-9 pubmed publisher..These and previous results using calbindin D9k null mutant mice illustrate that molecular events in the intestinal calcium absorption process in response to the active form of vitamin D remain to be defined. ..
- McCulloch D, Le Goff C, Bhatt S, Dixon L, Sandy J, Apte S. Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. Gene Expr Patterns. 2009;9:314-23 pubmed publisher..These observations suggest the major contexts in which developmental and physiological roles could be sought for this protease. ..
- Mohamed M, Frye R. Inhibition of intestinal and hepatic glucuronidation of mycophenolic acid by Ginkgo biloba extract and flavonoids. Drug Metab Dispos. 2010;38:270-5 pubmed publisher..These results indicate that G. biloba extract or quercetin- and kaempferol-rich supplements may inhibit intestinal and hepatic glucuronidation of MPA. Future studies are needed to evaluate the clinical significance of this interaction...
- Presley L, Wei B, Braun J, Borneman J. Bacteria associated with immunoregulatory cells in mice. Appl Environ Microbiol. 2010;76:936-41 pubmed publisher..Associations between the abundance of several bacterial phylotypes and immunoregulatory target cell types were identified, suggesting that they may play a role in these phenotypes. ..
- Perez F, Pultz M, Endimiani A, Bonomo R, Donskey C. Effect of antibiotic treatment on establishment and elimination of intestinal colonization by KPC-producing Klebsiella pneumoniae in mice. Antimicrob Agents Chemother. 2011;55:2585-9 pubmed publisher..The administration of nonabsorbed oral antibiotics may be an effective strategy to suppress colonization with KPC-Kp. ..
- Choi K, Joo H, Campbell J, Clewell R, Andersen M, Clewell H. In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat. Toxicol In Vitro. 2012;26:315-22 pubmed publisher..Percent total normalized rates (%TNR) by CYP2C9(?)1 in human liver microsomes (HLM) were 94%, 98% and 100%, respectively, for 5-OH MEHP, 5-Oxo MEHP, 5-carboxy MEPP, and 76% for PA production by CYP3A4. ..
- Strate L, Modi R, Cohen E, Spiegel B. Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights. Am J Gastroenterol. 2012;107:1486-93 pubmed publisher..This review addresses the emerging literature regarding epidemiology, pathophysiology, and management of chronic, symptomatic diverticular disease, and provides current answers to common clinical questions. ..
- Betcher M, Fung J, Han A, O CONNOR R, Seronay R, Concepcion G, et al. Microbial distribution and abundance in the digestive system of five shipworm species (Bivalvia: Teredinidae). PLoS ONE. 2012;7:e45309 pubmed publisher..In contrast, the comparatively high population density of bacteria in the intestine suggests a possible role for intestinal bacteria in the degradation of lignocellulose...
- Niederlechner S, Baird C, Petrie B, Wischmeyer E, Wischmeyer P. Epidermal growth factor receptor expression and signaling are essential in glutamine's cytoprotective mechanism in heat-stressed intestinal epithelial-6 cells. Am J Physiol Gastrointest Liver Physiol. 2013;304:G543-52 pubmed publisher..GLN-mediated EGFR signaling activated ERK1/2 and decreased p38MAPK signaling. However, GLN-mediated Akt phosphorylation after HS seems to be independent of EGFR signaling. ..
- Wiesenfahrt T, Berg J, Osborne Nishimura E, Robinson A, Goszczynski B, Lieb J, et al. The function and regulation of the GATA factor ELT-2 in the C. elegans endoderm. Development. 2016;143:483-91 pubmed publisher..Thus, in addition to controlling gene expression during differentiation, ELT-2 is capable of specifying the entire C. elegans endoderm. ..
- Watkins J, LaFollette J, Sanders R. Biotransformation in Egyptian spiny mouse Acomys cahirinus. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995;110:101-7 pubmed..No consistent relation appeared to exist between biotransformation activities in spiny mouse and those in other related rodent species. ..
- McGonigle S, Yoho E, James E. Immunisation of mice with fractions derived from the intestines of Dirofilaria immitis. Int J Parasitol. 2001;31:1459-66 pubmed
- Lyons E, DeLong R, Spraker T, Melin S, Tolliver S. Observations in 2001 on hookworms ( Uncinaria spp.) in otariid pinnipeds. Parasitol Res. 2003;89:503-5 pubmed..The apparent zero infection rate in these pups is possibly because the rocky terrain of this rookery is not suitable for hookworm transmission...
- Sugiura S, Ferraris R. Dietary phosphorus-responsive genes in the intestine, pyloric ceca, and kidney of rainbow trout. Am J Physiol Regul Integr Comp Physiol. 2004;287:R541-50 pubmed..Hence, these genes and NaPi-II are among the earliest steady-response genes capable of predicting P deficiency well before the onset of clinical deficiency. ..
- Poley J, Proud V. Hardikar syndrome: new features. Am J Med Genet A. 2008;146A:2473-9 pubmed publisher..It is intriguing to speculate, that HS could be genetically related to Alagille syndrome (AS), since both conditions share an unusual number of phenotypic abnormalities. ..
- Radulescu A, Zorko N, Yu X, Besner G. Preclinical neonatal rat studies of heparin-binding EGF-like growth factor in protection of the intestines from necrotizing enterocolitis. Pediatr Res. 2009;65:437-42 pubmed publisher..Thus, large-scale production of GMP-grade HB-EGF in Pichia pastoris yeast produces a biologically active molecule suitable for human clinical trials. ..
- Giannone P, Alcamo A, Schanbacher B, Nankervis C, Besner G, Bauer J. Poly(ADP-ribose) polymerase-1: a novel therapeutic target in necrotizing enterocolitis. Pediatr Res. 2011;70:67-71 pubmed publisher..We speculate that PARP-1 overactivation in NEC may drive mucosal cell death in this disease and that PARP-1 may be a novel therapeutic target in NEC. ..
- Allen R, Lafuse W, Galley J, Ali M, Ahmer B, Bailey M. The intestinal microbiota are necessary for stressor-induced enhancement of splenic macrophage microbicidal activity. Brain Behav Immun. 2012;26:371-82 pubmed publisher..This study demonstrates that the microbiota play a crucial role in stressor-induced immunoenhancement. ..
- Douard V, Sabbagh Y, Lee J, Patel C, Kemp F, Bogden J, et al. Excessive fructose intake causes 1,25-(OH)(2)D(3)-dependent inhibition of intestinal and renal calcium transport in growing rats. Am J Physiol Endocrinol Metab. 2013;304:E1303-13 pubmed publisher..This finding is significant because of the large amounts of fructose now consumed by Americans increasingly vulnerable to Ca(2+) and vitamin D deficiency. ..
- Dove W, Clipson L, Gould K, Luongo C, Marshall D, Moser A, et al. Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status. Cancer Res. 1997;57:812-4 pubmed..In parallel, we have found that C57BL/6-ApcMin/+ mice mutated at the beige locus, which controls natural killer activity, are also unaltered in adenoma multiplicity. ..