Genomes and Genes
Experts and Doctors on in United States
Locale: United States
Publications127 found, 100 shown here
- Montañez Wiscovich M, Shelton M, Seachrist D, Lozada K, Johnson E, Miedler J, et al. Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells. J Pathol. 2010;222:271-81 pubmed publisher..Furthermore, the correlation of centrosome amplification with genomic instability suggests that the impact of dysregulated LMO4 on the centrosome cycle may promote LMO4-induced tumour formation. ..
- Kieserman E, Wallingford J. In vivo imaging reveals a role for Cdc42 in spindle positioning and planar orientation of cell divisions during vertebrate neural tube closure. J Cell Sci. 2009;122:2481-90 pubmed publisher..Our data provide new insights into the coordination of cell division and morphogenesis in epithelial cell sheets and reveal novel, cell-type-specific roles for Cdc42 in spindle positioning and spindle orientation. ..
- Compton D. Chromosome segregation: pulling from the poles. Curr Biol. 2002;12:R651-3 pubmed..The data reveal that poleward microtubule flux provides the dominant force for separating chromatids in Drosophila embryos during anaphase A. ..
- Thompson S, Bakhoum S, Compton D. Mechanisms of chromosomal instability. Curr Biol. 2010;20:R285-95 pubmed publisher..Understanding these mechanisms provides insight into the cellular consequences of CIN and reveals the possibility of exploiting CIN in cancer therapy. ..
- Oakley B, Akkari Y. Gamma-tubulin at ten: progress and prospects. Cell Struct Funct. 1999;24:365-72 pubmed..Finally, there is evidence that gamma-tubulin has important functions in addition to microtubule nucleation, and these functions are just beginning to be investigated...
- Maney T, Hunter A, Wagenbach M, Wordeman L. Mitotic centromere-associated kinesin is important for anaphase chromosome segregation. J Cell Biol. 1998;142:787-801 pubmed..Live cell imaging indicates that MCAK may be required to coordinate the onset of sister centromere separation. ..
- Verbrugghe K, White J. Cortical centralspindlin and G alpha have parallel roles in furrow initiation in early C. elegans embryos. J Cell Sci. 2007;120:1772-8 pubmed..We also found spindle length or microtubule distribution did not correlate with furrow initiation. We propose that centralspindlin acts redundantly with G alpha to regulate furrow initiation. ..
- O Connell K, Caron C, Kopish K, Hurd D, Kemphues K, Li Y, et al. The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo. Cell. 2001;105:547-58 pubmed..ZYG-1 is therefore a key molecular component of the centrosome/centriole duplication process. ..
- Schmidt D, Rose D, Saxton W, Strome S. Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Mol Biol Cell. 2005;16:1200-12 pubmed..This suggests that temperature-sensitive mutations can be created for time-resolved function analyses of dyneins and perhaps other P-loop proteins in a variety of model systems. ..
- Dinkelmann M, Zhang H, Skop A, White J. SPD-3 is required for spindle alignment in Caenorhabditis elegans embryos and localizes to mitochondria. Genetics. 2007;177:1609-20 pubmed..elegans. To our knowledge, SPD-3 is the first example of a link between mitochondria and spindle alignment in C. elegans. ..
- Long B, Fairchild C. Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase. Cancer Res. 1994;54:4355-61 pubmed..It is proposed that this is the primary cytotoxic mechanism of paclitaxel. ..
- Gasparyan H, Xu L, Petreaca R, Rex A, Small V, Bhogal N, et al. Yeast telomere capping protein Stn1 overrides DNA replication control through the S phase checkpoint. Proc Natl Acad Sci U S A. 2009;106:2206-11 pubmed publisher..During replication stress, the mislocalized Stn1 may inappropriately promote Pol alpha in a manner that interferes with Rad53 effector mechanisms controlling replication fork integrity. ..
- Rajasekaran S, Christiansen J, Schmid I, Oshima E, Ryazantsev S, Sakamoto K, et al. Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability. Mol Cancer Ther. 2008;7:2142-51 pubmed publisher..Thus, these findings provide the first evidence that PSMA has a causal role in the induction of aneuploidy and might play an etiologic role in the progression of prostate cancer. ..
- Shanks R, Bascom Slack C, Dawson D. Analysis of the kar3 meiotic arrest in Saccharomyces cerevisiae. Cell Cycle. 2004;3:363-71 pubmed
- Sundberg H, Davis T. A mutational analysis identifies three functional regions of the spindle pole component Spc110p in Saccharomyces cerevisiae. Mol Biol Cell. 1997;8:2575-90 pubmed..Our results strongly argue that Spc110p links the gamma-tubulin complex to the central plaque of the SPB. ..
- Wise S, Holmes A, Xie H, Thompson W, Wise J. Chronic exposure to particulate chromate induces spindle assembly checkpoint bypass in human lung cells. Chem Res Toxicol. 2006;19:1492-8 pubmed..These data suggest that lead chromate does induce CIN and may be one mechanism in the development of Cr(VI)-induced lung cancer. ..
- Compton D, Luo C. Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis. J Cell Sci. 1995;108 ( Pt 2):621-33 pubmed
- Salina D, Enarson P, Rattner J, Burke B. Nup358 integrates nuclear envelope breakdown with kinetochore assembly. J Cell Biol. 2003;162:991-1001 pubmed..Mitotic arrest associated with Nup358 depletion further suggests that mitotic checkpoint complexes may remain active at nonkinetochore sites. ..
- Knowlton A, Brown H, Richards T, Andreolas L, Patel R, Grieshaber S. Chlamydia trachomatis infection causes mitotic spindle pole defects independently from its effects on centrosome amplification. Traffic. 2011;12:854-66 pubmed publisher..We hypothesize that these combined effects on mitotic spindle architecture identifies a possible mechanism for Chlamydia as a cofactor in cervical cancer formation. ..
- Place S, Smith B. Effects of seawater acidification on cell cycle control mechanisms in Strongylocentrotus purpuratus embryos. PLoS ONE. 2012;7:e34068 pubmed publisher..These data suggest low pH environments may not impact developmental programs directly, but may act through secondary mechanisms such as cellular energetics...
- Wilson P, Fuller M, Borisy G. Monastral bipolar spindles: implications for dynamic centrosome organization. J Cell Sci. 1997;110 ( Pt 4):451-64 pubmed..Since urchin proved to be allelic to KLP61F which encodes a kinesin related motor protein (Heck et al. (1993) J. Cell Biol. 123, 665-671), our results suggest that motors influence the dynamic organization of centrosomes. ..
- Bowerman B, Severson A. Cell division: plant-like properties of animal cell cytokinesis. Curr Biol. 1999;9:R658-60 pubmed..Recent evidence that a syntaxin is required for cytokinesis in Caenorhabditis elegans embryos suggests that the mechanism of cell division in plant and animal cells may be more similar than previously imagined. ..
- Jwa M, Kim J, Chan C. Regulation of Sli15/INCENP, kinetochore, and Cdc14 phosphatase functions by the ribosome biogenesis protein Utp7. J Cell Biol. 2008;182:1099-111 pubmed publisher..Thus, Utp7 is a multifunctional protein that plays essential roles in the vital cellular processes of ribosome biogenesis, chromosome segregation, and cell cycle control. ..
- Schlesinger A, Shelton C, Maloof J, Meneghini M, Bowerman B. Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell. Genes Dev. 1999;13:2028-38 pubmed..Orientation of the mitotic spindle does not require gene transcription in EMS, suggesting that Wnt signaling may directly target the cytoskeleton in a responding cell. ..
- Kang J, Cheeseman I, Kallstrom G, Velmurugan S, Barnes G, Chan C. Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol. 2001;155:763-74 pubmed..Given their dual association with microtubules and kinetochores, Ipl1, Sli15, and Dam1 may play crucial roles in regulating chromosome-spindle interactions or in the movement of kinetochores along microtubules. ..
- Mack G, Compton D. Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein. Proc Natl Acad Sci U S A. 2001;98:14434-9 pubmed..Thus, we have generated a comprehensive list of major mitotic microtubule-associated proteins, among which is astrin, a nonmotor spindle protein. ..
- Blanchard Z, Malik R, Mullins N, Maric C, Luk H, Horio D, et al. Geminin overexpression induces mammary tumors via suppressing cytokinesis. Oncotarget. 2011;2:1011-27 pubmed
- Eichenmuller B, Everley P, Palange J, Lepley D, Suprenant K. The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus. J Biol Chem. 2002;277:1301-9 pubmed..These data indicate that ELP70 is a novel MT destabilizer. A lateral destabilization model is presented to describe ELP70's effects on microtubules. ..
- Gong Y, Mo C, Fraser S. Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature. 2004;430:689-93 pubmed..Furthermore, we propose that non-canonical Wnt signalling has a conserved role in vertebrate axis elongation, orienting both cell intercalation and mitotic division. ..
- Walston T, Guo C, Proenca R, Wu M, Herman M, Hardin J, et al. mig-5/Dsh controls cell fate determination and cell migration in C. elegans. Dev Biol. 2006;298:485-97 pubmed..These defects demonstrate that MIG-5 is essential in determining proper cell fate and cell migration throughout C. elegans development. ..
- Zhang X, Lan W, Ems McClung S, Stukenberg P, Walczak C. Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function. Mol Biol Cell. 2007;18:3264-76 pubmed..Our study also shows that the interplay between multiple phosphorylation sites of MCAK may be critical to temporally and spatially control MCAK function. ..
- Liu H, De Souza C, Osmani A, Osmani S. The three fungal transmembrane nuclear pore complex proteins of Aspergillus nidulans are dispensable in the presence of an intact An-Nup84-120 complex. Mol Biol Cell. 2009;20:616-30 pubmed publisher..Therefore, the An-Nup84-120 complex performs roles, perhaps at the NPC membrane as proposed previously, that become essential without the An-Ndc1 transmembrane Nup. ..
- McGinnis L, Albertini D. Dynamics of protein phosphorylation during meiotic maturation. J Assist Reprod Genet. 2010;27:169-82 pubmed publisher..The findings indicate that distinct signaling pathways mediate nuclear and cytoplasmic maturation during in vitro maturation in a fashion consistent with a role for tyrosine kinases in cortical maturation and oocyte quality. ..
- Beh C, Brizzio V, Rose M. KAR5 encodes a novel pheromone-inducible protein required for homotypic nuclear fusion. J Cell Biol. 1997;139:1063-76 pubmed..We propose that Kar5p is required for the completion of nuclear membrane fusion and may play a role in the organization of the membrane fusion complex. ..
- Gordo A, He C, Smith S, Fissore R. Mitogen activated protein kinase plays a significant role in metaphase II arrest, spindle morphology, and maintenance of maturation promoting factor activity in bovine oocytes. Mol Reprod Dev. 2001;59:106-14 pubmed..In summary, our results demonstrate that in bovine oocytes MAPK activity is required for MII arrest, maintenance of MPF activity, and spindle organization. ..
- Yabe T, Ge X, Pelegri F. The zebrafish maternal-effect gene cellular atoll encodes the centriolar component sas-6 and defects in its paternal function promote whole genome duplication. Dev Biol. 2007;312:44-60 pubmed
- Torchia E, Chen Y, Sheng H, Katayama H, Fitzpatrick J, Brinkley W, et al. A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors. Cancer Res. 2009;69:7207-15 pubmed publisher..Our findings strongly implicate Aurora-A overexpression in the malignant progression of skin tumors and suggest that Aurora-A may be an important therapeutic target. ..
- Savoian M, Rieder C. Mitosis in primary cultures of Drosophila melanogaster larval neuroblasts. J Cell Sci. 2002;115:3061-72 pubmed
- Ganem N, Compton D. The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J Cell Biol. 2004;166:473-8 pubmed
- O Brien L, Albee A, Liu L, Tao W, Dobrzyn P, Lizarraga S, et al. The Xenopus TACC homologue, maskin, functions in mitotic spindle assembly. Mol Biol Cell. 2005;16:2836-47 pubmed..Together, these data suggest that in addition to its previously reported role as a translational regulator, maskin is also important for mitotic spindle assembly. ..
- Cui H, Ghosh S, Jayaram M. The selfish yeast plasmid uses the nuclear motor Kip1p but not Cin8p for its localization and equal segregation. J Cell Biol. 2009;185:251-64 pubmed publisher..Exploiting Kip1p, which is subsidiary to Cin8p for chromosome segregation, to direct itself to a "partitioning center" represents yet another facet of the benign parasitism of the yeast plasmid. ..
- Lutz W, Lingle W, McCormick D, Greenwood T, Salisbury J. Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication. J Biol Chem. 2001;276:20774-80 pubmed..Taken together, these results suggest that centrin phosphorylation signals the separation of centrosomes at prophase and implicates centrin phosphorylation in centriole separation that normally precedes centrosome duplication. ..
- Chen Q, Li H, De Lozanne A. Contractile ring-independent localization of DdINCENP, a protein important for spindle stability and cytokinesis. Mol Biol Cell. 2006;17:779-88 pubmed publisher..Finally, we show that the localization of DdINCENP at the cleavage furrow is modulated by myosin II but it occurs by a mechanism different from that controlling the formation of the contractile ring...
- Brito D, Rieder C. Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr Biol. 2006;16:1194-200 pubmed..Thus, vertebrate cells do not adapt to the SAC. Rather, our data suggest that in normal cells, the SAC cannot prevent a slow but continuous degradation of cyclin B that ultimately drives the cell out of mitosis. ..
- Simeonov D, Kenny K, Seo L, Moyer A, Allen J, Paluh J. Distinct Kinesin-14 mitotic mechanisms in spindle bipolarity. Cell Cycle. 2009;8:3571-83 pubmed..Our analysis is the first to demonstrate distinct mechanisms between SpPkl1 and DmNcd, and reveal that HsHSET shares functional overlap in spindle pole mechanisms. ..
- Gestaut D, Cooper J, Asbury C, Davis T, Wordeman L. Reconstitution and functional analysis of kinetochore subcomplexes. Methods Cell Biol. 2010;95:641-56 pubmed publisher..Here we outline methods for rapid cloning of polycistronic vectors for expression of kinetochore subcomplexes, their purification, and techniques for functional analysis using total internal reflection fluorescence microscopy (TIRFM). ..
- Klenchin V, Frye J, Jones M, Winey M, Rayment I. Structure-function analysis of the C-terminal domain of CNM67, a core component of the Saccharomyces cerevisiae spindle pole body. J Biol Chem. 2011;286:18240-50 pubmed publisher..Finally, the C-terminal eight residues are disordered but are critical for protein folding and structural stability. ..
- Ferhat L, Cook C, Kuriyama R, Baas P. The nuclear/mitotic apparatus protein NuMA is a component of the somatodendritic microtubule arrays of the neuron. J Neurocytol. 1998;27:887-99 pubmed..These observations provide an initial set of clues regarding a potentially important function of NuMA in the organization of microtubules within the somatodendritic compartment of the neuron. ..
- Biggins S, Murray A. The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes Dev. 2001;15:3118-29 pubmed..Ipl1p localizes at or near kinetochores during mitosis, and we propose that Ipl1p is required to monitor tension at the kinetochore. ..
- Faruki S, Cole R, Rieder C. Separating centrosomes interact in the absence of associated chromosomes during mitosis in cultured vertebrate cells. Cell Motil Cytoskeleton. 2002;52:107-21 pubmed..e., the RCC1/RanGTP pathway), but instead some other chromosomal component, e.g., kinetochores. ..
- Cai S, Weaver L, Ems McClung S, Walczak C. Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules. Mol Biol Cell. 2009;20:1348-59 pubmed publisher..Kinesin-14s act during mitosis to cross-link and slide between parallel microtubules to regulate spindle length. ..
- Yi K, Unruh J, Deng M, Slaughter B, Rubinstein B, Li R. Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes. Nat Cell Biol. 2011;13:1252-8 pubmed publisher..Thus, the asymmetric MII spindle position is dynamically maintained as a result of balanced forces governed by the Arp2/3 complex. ..
- Chang B, Smith L, Huang J, Thayer M. Chromosomes with delayed replication timing lead to checkpoint activation, delayed recruitment of Aurora B and chromosome instability. Oncogene. 2007;26:1852-61 pubmed..Finally, cells with DRT/DMC chromosomes have centrosome amplification, abnormal spindle assembly, endoreduplication and significant chromosome instability. ..
- Xiang Y, Takeo S, Florens L, Hughes S, Huo L, Gilliland W, et al. The inhibition of polo kinase by matrimony maintains G2 arrest in the meiotic cell cycle. PLoS Biol. 2007;5:e323 pubmed..Our data suggest a model in which the eventual activation of Cdc25 by an excess of Polo at stage 13 triggers NEB and entry into prometaphase. ..
- Navolanic P, Sperry A. Identification of isoforms of a mitotic motor in mammalian spermatogenesis. Biol Reprod. 2000;62:1360-9 pubmed..These experiments suggest that KIFC5-like motor proteins are associated with multiple microtubule complexes in male germ cells, including the meiotic spindle, the manchette, and the flagella. ..
- Levesque A, Compton D. The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. J Cell Biol. 2001;154:1135-46 pubmed..This force increases the efficiency with which chromosomes make bipolar spindle attachments and regulates kinetochore activities necessary for chromosome oscillation, but is not essential for chromosome congression. ..
- Kline Smith S, Khodjakov A, Hergert P, Walczak C. Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments. Mol Biol Cell. 2004;15:1146-59 pubmed..These findings reveal an essential role for Kin Is in prevention and/or correction of improper kinetochore-microtubule attachments. ..
- Verbrugghe K, White J. SPD-1 is required for the formation of the spindle midzone but is not essential for the completion of cytokinesis in C. elegans embryos. Curr Biol. 2004;14:1755-60 pubmed..Also, it can localize to the midzone when other midzone components are depleted, suggesting that SPD-1 may play an early role in the pathway of midzone assembly. ..
- Ganem N, Upton K, Compton D. Efficient mitosis in human cells lacking poleward microtubule flux. Curr Biol. 2005;15:1827-32 pubmed
- Hajra S, Ghosh S, Jayaram M. The centromere-specific histone variant Cse4p (CENP-A) is essential for functional chromatin architecture at the yeast 2-microm circle partitioning locus and promotes equal plasmid segregation. J Cell Biol. 2006;174:779-90 pubmed..Poaching of a specific histone variant by the plasmid to mark its partitioning locus with a centromere tag reveals yet another one of the molecular trickeries it performs for achieving chromosome- like fidelity in segregation. ..
- Eckert C, Gravdahl D, Megee P. The enhancement of pericentromeric cohesin association by conserved kinetochore components promotes high-fidelity chromosome segregation and is sensitive to microtubule-based tension. Genes Dev. 2007;21:278-91 pubmed
- McEwen B, Dong Y, VandenBeldt K. Using electron microscopy to understand functional mechanisms of chromosome alignment on the mitotic spindle. Methods Cell Biol. 2007;79:259-93 pubmed
- Zhang H, Skop A, White J. Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos. J Cell Sci. 2008;121:155-61 pubmed publisher..By RNAi of a weak dnc-1(ts) allele, we showed that dynactin activity was required at least for EMS spindle rotational alignment. ..
- Hughes S, Gilliland W, Cotitta J, Takeo S, Collins K, Hawley R. Heterochromatic threads connect oscillating chromosomes during prometaphase I in Drosophila oocytes. PLoS Genet. 2009;5:e1000348 pubmed publisher..We propose that these threads assist in the rejoining of homologs and the congression of the migrating achiasmate homologs back to the main chromosomal mass prior to metaphase arrest. ..
- Liu Y, Malureanu L, Jeganathan K, Tran D, Lindquist L, van Deursen J, et al. CAML loss causes anaphase failure and chromosome missegregation. Cell Cycle. 2009;8:940-9 pubmed..Thus, our data identify CAML as a novel chromosomal instability gene and suggest that CAML protein acts as a key regulator of mitotic spindle function and a modulator of SAC maintenance. ..
- Mauser J, Prehoda K. Inscuteable regulates the Pins-Mud spindle orientation pathway. PLoS ONE. 2012;7:e29611 pubmed publisher..Insc-regulated complex assembly may ensure that the spindle is attached to the cortex (via Dlg) before activation of spindle pulling forces by Dynein/Dynactin (via Mud). ..
- Kim J, Kang J, Chan C. Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. J Cell Biol. 1999;145:1381-94 pubmed..These genetic and biochemical studies indicate that Sli15 associates with Ipl1 to promote its function in chromosome segregation. ..
- Steadman B, Schmidt P, Shanks R, Lapierre L, Goldenring J. Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus. J Biol Chem. 2002;277:30165-76 pubmed publisher..We propose that AKAP350 is responsible for sequestration of TACC4 to the centrosome in interphase, whereas a separate TACC4 domain results in functional localization of TACC4 to the spindle apparatus in mitotic cells...
- Faitar S, Sossey Alaoui K, Ranalli T, Cowell J. EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. Exp Cell Res. 2006;312:2325-35 pubmed..Together, these data provide evidence that EVI5 is an essential component of the protein machinery facilitating the final stages of cell septation at the end of mitosis. ..
- Wiese C, Zheng Y. Microtubule nucleation: gamma-tubulin and beyond. J Cell Sci. 2006;119:4143-53 pubmed
- Zhang H, Squirrell J, White J. RAB-11 permissively regulates spindle alignment by modulating metaphase microtubule dynamics in Caenorhabditis elegans early embryos. Mol Biol Cell. 2008;19:2553-65 pubmed publisher..We hypothesize that RAB-11, in conjunction with the ER, acts to regulate cell cycle-specific changes in astral microtubule length to ensure proper spindle alignment in Caenorhabditis elegans early embryos. ..
- Ai E, Poole D, Skop A. RACK-1 directs dynactin-dependent RAB-11 endosomal recycling during mitosis in Caenorhabditis elegans. Mol Biol Cell. 2009;20:1629-38 pubmed publisher..Our findings suggest a mechanism by which RACK-1 directs the dynactin-dependent redistribution of recycling endosomes during the cell cycle, thus ensuring proper membrane trafficking events during cytokinesis. ..
- Graham A, Kiss D, Andrulis E. Core exosome-independent roles for Rrp6 in cell cycle progression. Mol Biol Cell. 2009;20:2242-53 pubmed publisher..Collectively, these data support the idea that dRrp6 has a core exosome-independent role in cell cycle and mitotic progression. ..
- Yabe T, Ge X, Lindeman R, Nair S, Runke G, Mullins M, et al. The maternal-effect gene cellular island encodes aurora B kinase and is essential for furrow formation in the early zebrafish embryo. PLoS Genet. 2009;5:e1000518 pubmed publisher..In accordance with the requirement for cei/aurB in furrow induction in the early cleavage embryo, germ plasm recruitment to the forming furrow is also affected in embryos lacking normal cei/aurB function. ..
- McGinnis L, Hong X, Christenson L, Kinsey W. Fer tyrosine kinase is required for germinal vesicle breakdown and meiosis-I in mouse oocytes. Mol Reprod Dev. 2011;78:33-47 pubmed publisher..The results demonstrate that FER kinase plays a critical role in oocyte meiotic spindle microtubule dynamics and may have an additional function in GVBD. ..
- Hafer N, Xu S, Bhat K, Schedl P. The Drosophila CPEB protein Orb2 has a novel expression pattern and is important for asymmetric cell division and nervous system function. Genetics. 2011;189:907-21 pubmed publisher..We also show that orb2 funtions in asymmetric division of stem cells and precursor cells during the development of the embryonic nervous system and mesoderm. ..
- Brockman J, Gross S, Sussman M, Anderson R. Cell cycle-dependent localization of casein kinase I to mitotic spindles. Proc Natl Acad Sci U S A. 1992;89:9454-8 pubmed..This localization suggests that alpha-CKI, like HRR25, plays a role in the segregation of chromosomes during mitosis and may be cell cycle-regulated both in humans and in yeast. ..
- Burland T, Paul E, Oetliker M, Dove W. A gene encoding the major beta tubulin of the mitotic spindle in Physarum polycephalum plasmodia. Mol Cell Biol. 1988;8:1275-81 pubmed..Alternatively, restricted use of beta tubulins may allow positive selection to operate more freely to refine beta-tubulin function...
- Holy J. Chlorpropham [isopropyl N-(3-chlorophenyl) carbamate] disrupts microtubule organization, cell division, and early development of sea urchin embryos. J Toxicol Environ Health A. 1998;54:319-33 pubmed
- O Connell K, Leys C, White J. A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans. Genetics. 1998;149:1303-21 pubmed..We conclude that this approach can be used to identify mutations that affect various aspects of the cell-division cycle. ..
- Flory M, Morphew M, Joseph J, Means A, Davis T. Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe. Cell Growth Differ. 2002;13:47-58 pubmed
- Thompson H, Skop A, Euteneuer U, Meyer B, McNiven M. The large GTPase dynamin associates with the spindle midzone and is required for cytokinesis. Curr Biol. 2002;12:2111-7 pubmed..These findings indicate that, during mitosis, conventional dynamin is recruited to the spindle midzone and the subsequent intercellular bridge, where it plays an essential role in the final separation of dividing cells. ..
- Ovechkina Y, Maddox P, Oakley C, Xiang X, Osmani S, Salmon E, et al. Spindle formation in Aspergillus is coupled to tubulin movement into the nucleus. Mol Biol Cell. 2003;14:2192-200 pubmed..nidulans. They suggest that regulation of protein movement into the nucleoplasm may be important for regulating mitotic onset in organisms with intranuclear mitosis...
- Siegrist S, Doe C. Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts. Cell. 2005;123:1323-35 pubmed..These results identify a role for microtubules in polarizing the neuroblast cortex, a fundamental step for generating cell diversity through asymmetric cell division. ..
- Warsi T, Navarro M, Bachant J. DNA topoisomerase II is a determinant of the tensile properties of yeast centromeric chromatin and the tension checkpoint. Mol Biol Cell. 2008;19:4421-33 pubmed publisher..In sum, Top2 seems to play a novel role in CEN compaction that is distinct from decatenation. Perturbations to this function may allow weakened kinetochores to stretch CENs in a manner that mimics tension or evades Ipl1 surveillance. ..
- Manning A, Bakhoum S, Maffini S, Correia Melo C, Maiato H, Compton D. CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity. EMBO J. 2010;29:3531-43 pubmed publisher..Thus, CLASP1-astrin-Kif2b complex act as a central switch at kinetochores that defines mitotic progression and promotes fidelity by temporally regulating kMT attachments. ..
- Duncan A, Taylor M, Hickey R, Hanlon Newell A, Lenzi M, Olson S, et al. The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature. 2010;467:707-10 pubmed publisher..We propose that this mechanism evolved to generate genetic diversity and permits adaptation of hepatocytes to xenobiotic or nutritional injury. ..
- Pal D, Wu D, Haruta A, Matsumura F, Wei Q. Role of a novel coiled-coil domain-containing protein CCDC69 in regulating central spindle assembly. Cell Cycle. 2010;9:4117-29 pubmed..Our results indicate that CCDC69 acts as a scaffold to regulate the recruitment of midzone components and the assembly of central spindles. ..
- Lodde V, Peluso J. A novel role for progesterone and progesterone receptor membrane component 1 in regulating spindle microtubule stability during rat and human ovarian cell mitosis. Biol Reprod. 2011;84:715-22 pubmed publisher..Taken together, these results suggest that P4 inhibits mitosis of ovarian cells by increasing the stability of the mitotic spindle. Moreover, P4's actions appear to be dependent on PGRMC1's function within the mitotic spindle. ..