Genomes and Genes
Experts and Doctors on in United States
Locale: United States
- Wayne M, Soundararajan U, Harshman L. Environmental stress and reproduction in Drosophila melanogaster: starvation resistance, ovariole numbers and early age egg production. BMC Evol Biol. 2006;6:57 pubmed..Further, ovariole number increased in a parallel response to maternal starvation, suggesting an evolutionary association between maternal environment and the reproductive system of female progeny. ..
- Dai L, Dewey E, Zitnan D, Luo C, Honegger H, Adams M. Identification, developmental expression, and functions of bursicon in the tobacco hawkmoth, Manduca sexta. J Comp Neurol. 2008;506:759-74 pubmed..Recombinant bursicon induces both wing expansion and tanning, whereas synthetic eclosion hormone induces only wing expansion...
- Ogden S, Casso D, Ascano M, Yore M, Kornberg T, Robbins D. Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. J Biol Chem. 2006;281:7237-43 pubmed
- Parks A, Klueg K, Stout J, Muskavitch M. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development. 2000;127:1373-85 pubmed..We suggest that endocytosis into delta-expressing cells of NotchECD bound to delta plays a critical role during activation of the Notch receptor and is required to achieve processing and dissociation of the Notch protein. ..
- Bantignies F, Goodman R, Smolik S. Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers. Mol Cell Biol. 2000;20:9317-30 pubmed..Our results thus implicate a second class of chromatin-associated proteins in mediating dCBP function and imply that dCBP might be involved in the regulation of higher-order chromatin structure. ..
- Schnepp B, Donaldson T, Grumbling G, Ostrowski S, Schweitzer R, Shilo B, et al. EGF domain swap converts a drosophila EGF receptor activator into an inhibitor. Genes Dev. 1998;12:908-13 pubmed..These results demonstrate that the EGF domain is the key determinant that gives DER inhibitors and activators their distinct properties. ..
- Carvalho G, Ja W, Benzer S. Non-lethal PCR genotyping of single Drosophila. Biotechniques. 2009;46:312-4 pubmed publisher..This advance should significantly facilitate several of the most fundamental and routine techniques in Drosophila genetics. ..
- Rulifson E, Micchelli C, Axelrod J, Perrimon N, Blair S. wingless refines its own expression domain on the Drosophila wing margin. Nature. 1996;384:72-4 pubmed..Cells unable to receive the Wg signal do not resolve the boundary between wg-expressing and proneural cells. ..
- Tomoyasu Y, Wheeler S, Denell R. Ultrabithorax is required for membranous wing identity in the beetle Tribolium castaneum. Nature. 2005;433:643-7 pubmed..This counteracting effect of Ubx in beetle hindwings represents a previously unknown mode of wing diversification in insects. ..
- Kimble M, Incardona J, Raff E. A variant beta-tubulin isoform of Drosophila melanogaster (beta 3) is expressed primarily in tissues of mesodermal origin in embryos and pupae, and is utilized in populations of transient microtubules. Dev Biol. 1989;131:415-29 pubmed..In both developing muscles and wings our results indicate that beta 3-tubulin is utilized in populations of specialized but transient cytoskeletal microtubules which are involved in establishing the final form of the tissue. ..
- Monteiro A, Chen B, Scott L, Vedder L, Prijs H, Belicha Villanueva A, et al. The combined effect of two mutations that alter serially homologous color pattern elements on the fore and hindwings of a butterfly. BMC Genet. 2007;8:22 pubmed..Spotty, unlike Missing, may be under Ubx gene regulation, since it affects a subset of eyespots on only one of the serially homologous wings. ..
- Deshpande G, Schedl P. HMGCoA reductase potentiates hedgehog signaling in Drosophila melanogaster. Dev Cell. 2005;9:629-38 pubmed..Consistent with this model, there are substantial germ cell migration defects in trans combinations between hmgcr and mutations in different components of the hh pathway. ..
- Roff D, Fairbairn D. Laboratory evolution of the migratory polymorphism in the sand cricket: combining physiology with quantitative genetics. Physiol Biochem Zool. 2007;80:358-69 pubmed..These results demonstrate the power of combining quantitative genetic and physiological approaches for understanding the evolution of complex traits. ..
- Casso D, Liu S, Iwaki D, Ogden S, Kornberg T. A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Genetics. 2008;178:1399-413 pubmed publisher..Characterization of newly isolated alleles indicates that swm is a negative regulator of Hh signaling and is essential for cell polarity. ..
- Rayburn L, Gooding H, Choksi S, Maloney D, Kidd A, Siekhaus D, et al. amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development. Genetics. 2003;163:227-37 pubmed
- Conley C, Silburn R, Singer M, Ralston A, Rohwer Nutter D, Olson D, et al. Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila. Development. 2000;127:3947-59 pubmed..These features strongly suggest that Crossveinless 2 acts extracelluarly or in the secretory pathway to directly potentiate Dpp or Gbb signaling. ..
- Blair S. Engrailed expression in the anterior lineage compartment of the developing wing blade of Drosophila. Development. 1992;115:21-33 pubmed..A decapentaplegic-lacZ construct was expressed in a stripe several cells anterior to the lineage boundary, and did not define or overlap into the posterior lineage compartment. ..
- Maimon G, Straw A, Dickinson M. Active flight increases the gain of visual motion processing in Drosophila. Nat Neurosci. 2010;13:393-9 pubmed publisher..The ability to perform patch-clamp recordings in behaving Drosophila promises to help unify the understanding of behavior at the gene, cell and circuit levels. ..
- Carroll S, Gates J, Keys D, Paddock S, Panganiban G, Selegue J, et al. Pattern formation and eyespot determination in butterfly wings. Science. 1994;265:109-14 pubmed..These circular pattern elements appear to be generated by a process similar to, and perhaps evolved from, proximodistal pattern formation in insect appendages. ..
- Blair S, Ralston A. Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila. Development. 1997;124:4053-63 pubmed..Our results suggest that compartmentalization is a complex process involving intercompartmental signalling; models based on changes in affinity or growth will be discussed. ..
- Matakatsu H, Blair S. Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins. Development. 2006;133:2315-24 pubmed..Finally, we show that ft mutants or a dominant-negative Ft construct can affect disc growth without changes in the expression of wingless and Wingless target genes. ..
- Fisher M, Meyer C, Garber G, Dealy C. Role of IGFBP2, IGF-I and IGF-II in regulating long bone growth. Bone. 2005;37:741-50 pubmed..Our results emphasize the importance of a balance of IGF/IGFBP2 action at several stages during normal long bone development. ..
- Wandler A, Guillemin K. Transgenic expression of the Helicobacter pylori virulence factor CagA promotes apoptosis or tumorigenesis through JNK activation in Drosophila. PLoS Pathog. 2012;8:e1002939 pubmed publisher..These data suggest a potential role for CagA-mediated JNK pathway activation in promoting gastric cancer progression. ..
- Chu J, Dong P, Panganiban G. Limb type-specific regulation of bric a brac contributes to morphological diversity. Development. 2002;129:695-704 pubmed..We propose that the limb type-specific variations in expression of bric a brac repressors contribute to morphological variations by controlling distal limb segment number. ..
- Roff D. Inbreeding depression: tests of the overdominance and partial dominance hypotheses. Evolution. 2002;56:768-75 pubmed..These results provide support for the partial dominance hypothesis and are inconsistent with the overdominance hypothesis. ..
- Clark D. Molecular and genetic analyses of Drosophila Prat, which encodes the first enzyme of de novo purine biosynthesis. Genetics. 1994;136:547-57 pubmed
- Roff D, Fairbairn D. The costs of being dark: the genetic basis of melanism and its association with fitness-related traits in the sand cricket. J Evol Biol. 2013;26:1406-16 pubmed publisher..Our results support the general hypothesis that melanization is costly for insects and negatively impacts investment in early reproduction. ..
- Wu Y, Bolduc F, Bell K, Tully T, Fang Y, Sehgal A, et al. A Drosophila model for Angelman syndrome. Proc Natl Acad Sci U S A. 2008;105:12399-404 pubmed publisher..We conclude that dube3a mutants are a valid model for Angelman syndrome, with great potential for identifying the elusive UBE3A substrates relevant to the disease. ..
- Micchelli C, Blair S. Dorsoventral lineage restriction in wing imaginal discs requires Notch. Nature. 1999;401:473-6 pubmed..Here we show that the formation of Notch-dependent boundary cells is required for the D/V lineage restriction. ..
- Ascano M, Robbins D. An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling. Mol Cell Biol. 2004;24:10397-405 pubmed..Our results here enhance our understanding of one of the least characterized, yet critical, components of Hh signal transduction. ..
- Craig T, Itami J, Horner J. Geographic variation in the evolution and coevolution of a tritrophic interaction. Evolution. 2007;61:1137-52 pubmed..solidaginis. The parasitoid had significantly longer ovipositors in the prairie than in the forest, indicating the possibility that it has evolved in response to selection to reach larvae in the larger-diameter prairie galls...
- Warmke J, Yamakawa M, Molloy J, Falkenthal S, Maughan D. Myosin light chain-2 mutation affects flight, wing beat frequency, and indirect flight muscle contraction kinetics in Drosophila. J Cell Biol. 1992;119:1523-39 pubmed..Furthermore, these results suggest that the reduced wing beat frequency and possibly the flightless behavior conferred by Mlc2E38 is due in part to slower contraction kinetics of sarcomeric regions devoid or partly deficient in MLC-2. ..
- Malvadkar N, Hancock M, Sekeroglu K, Dressick W, Demirel M. An engineered anisotropic nanofilm with unidirectional wetting properties. Nat Mater. 2010;9:1023-8 pubmed publisher..An accompanying comprehensive model successfully describes the film's anisotropic wetting behaviour as a function of measurable film morphology parameters. ..
- Galant R, Walsh C, Carroll S. Hox repression of a target gene: extradenticle-independent, additive action through multiple monomer binding sites. Development. 2002;129:3115-26 pubmed
- Halder G, Polaczyk P, Kraus M, Hudson A, Kim J, Laughon A, et al. The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila. Genes Dev. 1998;12:3900-9 pubmed..Combinatorial regulation by selector proteins and signal transducers is likely to be a general feature of the tissue-specific control of gene expression during organogenesis. ..
- Zhang J, Liu M, Su Y, Du J, Zhu A. A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling. G3 (Bethesda). 2012;2:1563-75 pubmed publisher..Our study reveals a conserved molecular mechanism by which protein deubiquitination process contributes to the complex posttranslational regulation of Notch signaling in vivo. ..
- Matakatsu H, Blair S. The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity. Curr Biol. 2008;18:1390-5 pubmed publisher..We show that App encodes a member of the DHHC family, responsible for the palmitoylation of selected cytoplasmic proteins, and provide evidence that App acts by controlling the normal subcellular localization and activity of Dachs. ..
- Ralston A, Blair S. Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone. Dev Biol. 2005;280:187-200 pubmed..However, this requirement can be overridden by co-misexpression of the BMP agonist Cv-2, indicating the presence of as yet unknown cues; we discuss possible candidates. ..
- Gompel N, Prud homme B, Wittkopp P, Kassner V, Carroll S. Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila. Nature. 2005;433:481-7 pubmed
- Collier S, Lee H, Burgess R, Adler P. The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis. Genetics. 2005;169:2035-45 pubmed..We show that the fritz gene product functions cell-autonomously downstream of the core PCP proteins to regulate both the location and the number of wing cell prehair initiation sites. ..
- Loehlin D, Oliveira D, Edwards R, Giebel J, Clark M, Cattani M, et al. Non-coding changes cause sex-specific wing size differences between closely related species of Nasonia. PLoS Genet. 2010;6:e1000821 pubmed publisher..This study demonstrates the feasibility of efficient positional cloning of quantitative trait loci (QTL) involved in a broad array of phenotypic differences among Nasonia species...
- Evans T, Haridas H, Duffy J. Kekkon5 is an extracellular regulator of BMP signaling. Dev Biol. 2009;326:36-46 pubmed publisher..Our identification of Kek5 as a modulator of BMP signaling supports the emerging notion that LIG proteins function as diverse regulators of cellular communication. ..
- Engel M, Gross M. A giant termite from the Late Miocene of Styria, Austria (Isoptera). Naturwissenschaften. 2009;96:289-95 pubmed publisher..The genus is primitive in overall features but shares some similarity with the dampwood termites. ..
- Li X, Graner M, Williams E, Roote C, Bunch T, Zusman S. Requirements for the cytoplasmic domain of the alphaPS1, alphaPS2 and betaPS integrin subunits during Drosophila development. Development. 1998;125:701-11 pubmed..Furthermore, temperature-shift experiments suggest roles for the alphaPS2 cytoplasmic domain in signaling events occurring in the developing wing. ..
- Doyle K, Hogan J, Lester M, Collier S. The Frizzled Planar Cell Polarity signaling pathway controls Drosophila wing topography. Dev Biol. 2008;317:354-67 pubmed publisher..Our data suggest that isoforms of the Fz PCP pathway protein Prickle are differentially required for the two PCP Phases, with the Spiny-legs isoform primarily active in the Early PCP Phase and the Prickle isoform in the Late PCP Phase. ..
- Micchelli C, Rulifson E, Blair S. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development. 1997;124:1485-95 pubmed..We propose that the boundary of Notch ligand along the normal margin plays a similar role as part of a dynamic feedback loop that maintains the tripartite pattern of margin gene expression. ..
- O Keefe D, Gonzalez Niño E, Burnett M, Dylla L, Lambeth S, Licon E, et al. Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila. Dev Biol. 2009;333:143-60 pubmed publisher..Finally, we show that Rap1 acts through the effector Canoe to regulate these developmental processes. ..
- Huh J, Guo M, Hay B. Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role. Curr Biol. 2004;14:1262-6 pubmed..We speculate that dying cells may communicate cell fate or behavior instructions to their neighbors in other contexts as well. ..
- Blair S, Brower D, Thomas J, Zavortink M. The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila. Development. 1994;120:1805-15 pubmed..Thus, apterous plays a selector-like role both in terms of the control of lineage restrictions and the regulation of downstream gene expression. ..
- Swank D, Kronert W, Bernstein S, Maughan D. Alternative N-terminal regions of Drosophila myosin heavy chain tune muscle kinetics for optimal power output. Biophys J. 2004;87:1805-14 pubmed..Thus the N-terminal region is important in tuning myosin kinetics to match muscle speed for optimal locomotory performance. ..
- Ahmed A, Chandra S, Magarinos M, Vaessin H. Echinoid mutants exhibit neurogenic phenotypes and show synergistic interactions with the Notch signaling pathway. Development. 2003;130:6295-304 pubmed..Our work establishes a role of Ed during embryonic nervous system development, as well as adult sensory bristle specification and shows that Ed interacts synergistically with the Notch signaling pathway. ..
- Johnston L, Edgar B. Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. Nature. 1998;394:82-4 pubmed..Notch activity creates a third domain by preventing arrest at G2 in wg-expressing cells, resulting in their arrest in G1. ..
- Vance J, Faruque I, Humbert J. Kinematic strategies for mitigating gust perturbations in insects. Bioinspir Biomim. 2013;8:016004 pubmed publisher..Both insects coordinated asymmetric and symmetric kinematics in response to gusts, which provides model strategies for simple yet robust flight characteristics for MAVs. ..
- Peng Y, Axelrod J. Asymmetric protein localization in planar cell polarity: mechanisms, puzzles, and challenges. Curr Top Dev Biol. 2012;101:33-53 pubmed publisher..It is likely that results from Drosophila will continue to inform our views of the growing list of examples of PCP in vertebrate systems. ..
- Matakatsu H, Blair S. Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous. Development. 2012;139:1498-508 pubmed publisher..We also found that the extracellular domain of Ft can act independently of the Ft ICD in PCP and can trigger dominant-negative and boundary effects on Hippo activity, probably via binding to the protocadherin Dachsous. ..
- Blair S, Giangrande A, Skeath J, Palka J. The development of normal and ectopic sensilla in the wings of hairy and Hairy wing mutants of Drosophila. Mech Dev. 1992;38:3-16 pubmed..Rather, both act to induce the formation of a temporally and spatially distinct phase of sensillar development. ..
- Hersh B, Nelson C, Stoll S, Norton J, Albert T, Carroll S. The UBX-regulated network in the haltere imaginal disc of D. melanogaster. Dev Biol. 2007;302:717-27 pubmed..The evolution of haltere morphology involved changes in UBX-regulated target genes, both positive and negative, throughout the wing genetic regulatory network. ..
- Neufeld T, de la Cruz A, Johnston L, Edgar B. Coordination of growth and cell division in the Drosophila wing. Cell. 1998;93:1183-93 pubmed..We infer that dE2F and RBF function specifically in cell cycle control, and that cell cycle acceleration is insufficient to stimulate growth. Variations in dE2F activity could be used to coordinate cell division with growth. ..
- Kim J, Johnson K, Chen H, Carroll S, Laughon A. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature. 1997;388:304-8 pubmed..Mad also binds to Dpp-response elements in other genes. These results suggest that Dpp signalling regulates gene expression by activating Mad binding to target gene enhancers. ..
- Staehling Hampton K, Laughon A, Hoffmann F. A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling. Development. 1995;121:3393-403 pubmed..We conclude that shn function is critical for cells to respond properly to dpp and propose that shn protein is the first identified downstream component of the signal transduction pathway used by dpp and its receptors. ..
- Tinghitella R. Rapid evolutionary change in a sexual signal: genetic control of the mutation 'flatwing' that renders male field crickets (Teleogryllus oceanicus) mute. Heredity (Edinb). 2008;100:261-7 pubmed
- Paddock S, DeVries P, Buth E, Carroll S. Morphing: a new graphics tool for animating confocal images. Biotechniques. 1994;16:448-52 pubmed..It is anticipated that morphing can be applied not only to the display and analysis of developing systems but also to the elucidation of evolutionary relationships between species and to comparative anatomy. ..
- Blochlinger K, Jan L, Jan Y. Postembryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila. Development. 1993;117:441-50 pubmed..Finally, we observe cut-expressing cells in other adult tissues, including Malpighian tubules, muscles, the central nervous system and ovarian follicle cells...
- Yu T, Bachman J, Lai Z. Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer. Genetics. 2013;195:1193-6 pubmed publisher..hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations. ..
- Rulifson E, Blair S. Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila. Development. 1995;121:2813-24 pubmed..Furthermore, overexpression of wingless with a heat shock-wingless construct rescued the loss of sensory precursors associated with the early loss of Notch. ..
- Kim J, Irvine K, Carroll S. Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing. Cell. 1995;82:795-802 pubmed..Ser in turn triggers the expression of genes involved in wing growth and patterning on both sides of the DV boundary. ..
- Swaminathan A, Barnes V, Fox S, Gammouh S, Pile L. Identification of genetic suppressors of the Sin3A knockdown wing phenotype. PLoS ONE. 2012;7:e49563 pubmed publisher..These data indicate that Sin3A function is quite diverse and impacts a wide variety of cellular processes. ..
- Nagy L, Carroll S. Conservation of wingless patterning functions in the short-germ embryos of Tribolium castaneum. Nature. 1994;367:460-3 pubmed
- Reiskind M, Zarrabi A. Is bigger really bigger? Differential responses to temperature in measures of body size of the mosquito, Aedes albopictus. J Insect Physiol. 2012;58:911-7 pubmed publisher..We therefore reject our hypothesis and propose several testable mechanisms that will provide greater insight into the relationship between temperature, food, and measures of growth...
- Penton A, Hoffmann F. Decapentaplegic restricts the domain of wingless during Drosophila limb patterning. Nature. 1996;382:162-4 pubmed..Such negative regulatory feedback loops between signalling molecules are likely to be critical for limb patterning in other species. ..
- Roff D, Fairbairn D. Path analysis of the genetic integration of traits in the sand cricket: a novel use of BLUPs. J Evol Biol. 2011;24:1857-69 pubmed publisher..Our results illustrate the benefits of combining a quantitative genetic analysis, which examines statistical correlations between traits, with a path model that focuses upon the causal components of variation. ..
- Johnston L, Prober D, Edgar B, Eisenman R, Gallant P. Drosophila myc regulates cellular growth during development. Cell. 1999;98:779-90 pubmed..Our results indicate that dMyc links patterning signals to cell division by regulating primary targets involved in cellular growth and metabolism. ..
- Skeath J, Carroll S. Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. Genes Dev. 1991;5:984-95 pubmed..Some or all of these interactions may involve specific dimerization reactions between different combinations of HLH proteins. ..
- Bixler G, Bhushan B. Fluid drag reduction and efficient self-cleaning with rice leaf and butterfly wing bioinspired surfaces. Nanoscale. 2013;5:7685-710 pubmed publisher..Modeling provides design guidance when developing novel low drag and self-cleaning surfaces for applications in the medical, marine, and industrial fields. ..
- Prober D, Edgar B. Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev. 2002;16:2286-99 pubmed
- Zraly C, Marenda D, Dingwall A. SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex. Genetics. 2004;168:199-214 pubmed..Thus, in addition to important functions of the Brm complex in G1-S control, the complex also appears to be important for transcription of genes required for cell cycle progression. ..
- Deshpande G, Zhou K, Wan J, Friedrich J, Jourjine N, Smith D, et al. The hedgehog pathway gene shifted functions together with the hmgcr-dependent isoprenoid biosynthetic pathway to orchestrate germ cell migration. PLoS Genet. 2013;9:e1003720 pubmed publisher..Finally, potentiation of Hh by hmgcr appears to depend upon cholesterol modification. ..