Experts and Doctors on in United States


Locale: United States

Top Publications

  1. Chandler L, Sutton G, Dorairaj N, Norwood D. N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures. J Biol Chem. 2001;276:2627-36 pubmed
    ..These results suggests that NMDA receptors can bidirectionally control ERK signaling. ..
  2. Pedram A, Razandi M, Levin E. Deciphering vascular endothelial cell growth factor/vascular permeability factor signaling to vascular permeability. Inhibition by atrial natriuretic peptide. J Biol Chem. 2002;277:44385-98 pubmed
    ..Thus, ANP acts as an anti-permeability factor by inhibiting the signaling functions of VPF that we define here and by preserving the endothelial cell TJ functional morphology. ..
  3. Zhang Y, Hong Y, Bounhar Y, Blacker M, Roucou X, Tounekti O, et al. p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity. J Neurosci. 2003;23:7385-94 pubmed
    ..Neuroprotection against Abeta is phosphatidylinositide 3-kinase dependent but Akt independent. These results are consistent with a neuroprotective role for p75NTR against extracellular Abeta toxicity in human neurons. ..
  4. Kim K, Ren J, Jiang Y, Ebrahem Q, Tipps R, Cristina K, et al. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. FASEB J. 2005;19:819-21 pubmed
    ..Moreover, the effects of SPC on EC require SPC induced trans-phosphorylation and activation of the VEGF receptor 2. These results identify SPC and its receptor, GPR4, as critical regulators of the angiogenic potential of EC. ..
  5. Fang P, Hwa V, Rosenfeld R. Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway. Exp Cell Res. 2006;312:1229-39 pubmed
    ..Our study thus provides novel insights into the contributions of signaling pathways other than the classical JAK/STAT1 pathway in the anti-proliferative, proapoptotic actions of IFN-gamma. ..
  6. Nitta T, Kim J, Mohuczy D, Behrns K. Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways. Hepatology. 2008;48:909-19 pubmed publisher
    ..These findings may have clinical implications for chemoprevention of hepatocellular carcinoma in the cirrhotic liver. ..
  7. Tallquist M, Klinghoffer R, Heuchel R, Mueting Nelsen P, Corrin P, Heldin C, et al. Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways. Genes Dev. 2000;14:3179-90 pubmed
    ..Our observations indicate that although loss of these pathways can lead to attenuated PDGF-dependent cellular function, certain PDGFR-beta-induced signal cascades are not essential for survival in mice. ..
  8. Ling X, Bernacki R, Brattain M, Li F. Induction of survivin expression by taxol (paclitaxel) is an early event, which is independent of taxol-mediated G2/M arrest. J Biol Chem. 2004;279:15196-203 pubmed
    ..This appears to be a new mechanism for cancer cells to evade taxol-induced apoptosis. Targeting this survival pathway may result in novel approaches for cancer therapeutics. ..
  9. Ma Y, Toth B, Keeton A, Holland L, Chaudry I, Messina J. Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha. Endocrinology. 2004;145:5168-76 pubmed
    ..Increased local TNFalpha may play a role in inducing this hepatic insulin resistance after trauma and hemorrhage. ..

More Information

Publications252 found, 100 shown here

  1. Keeton A, Bortoff K, Franklin J, Messina J. Blockade of rapid versus prolonged extracellularly regulated kinase 1/2 activation has differential effects on insulin-induced gene expression. Endocrinology. 2005;146:2716-25 pubmed
  2. Dhandapani K, Wade F, Mahesh V, Brann D. Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways. Endocrinology. 2005;146:2749-59 pubmed
  3. Ritch P, Carroll S, Sontheimer H. Neuregulin-1 enhances survival of human astrocytic glioma cells. Glia. 2005;51:217-28 pubmed
    ..This data suggests that glioma cells may use autocrine or paracrine neuregulin-1/erbB receptor signaling to enhance cell survival under conditions where growth would otherwise be limited. ..
  4. Rehani K, Wang H, Garcia C, Kinane D, Martin M. Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2. J Immunol. 2009;182:547-53 pubmed
    ..Our findings identify that GSK3 negatively regulates the levels of IL-1Ra produced by LPS-stimulated innate immune cells. ..
  5. Ruhland A, Kima P. Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonensis promastigotes. Exp Parasitol. 2009;122:28-36 pubmed publisher
    ..PI3K signaling activated by the infection is the negative signaling pathway that prevents IL-12 production. ..
  6. Garcia C, Wang H, Benakanakere M, Barrett E, Kinane D, Martin M. c-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells. J Immunol. 2009;183:4475-82 pubmed publisher
    ..These studies identify the cellular mechanism by which IL-12 induces IL-10 production from human memory CD4+ T cells. ..
  7. Dowdy S, Mariani A, Janknecht R. HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81. J Biol Chem. 2003;278:44377-84 pubmed
    ..This suggests that attenuation of TGF-beta signaling by activating Smad7 transcription may proceed not only through TGF-beta receptor-regulated Smad proteins but also through an independent pathway involving ER81 and TAK1. ..
  8. Lee J, Anderson P, Padgitt J, Hanson J, Waters C, Johnson J. Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element. Biochim Biophys Acta. 2003;1629:92-101 pubmed
    ..Taken together, these observations suggest that 4-hydroxyestradiol activates the ARE by a PI3-kinase-Nrf2 dependent mechanism, not involving ER. ..
  9. Aramoto H, Breslin J, Pappas P, Hobson R, Duran W. Vascular endothelial growth factor stimulates differential signaling pathways in in vivo microcirculation. Am J Physiol Heart Circ Physiol. 2004;287:H1590-8 pubmed
    ..Our data provide evidence for differential signaling as a regulatory step in VEGF-stimulated microvascular dynamics. ..
  10. Orr A, Pallero M, Murphy Ullrich J. Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation. J Biol Chem. 2002;277:20453-60 pubmed
    ..These data show that G(i) protein and ERK, in concert with PI3K, are stimulated by TSP.CRT interactions at the cell surface to induce de-adhesive changes in the cytoskeleton. ..
  11. Kirwan J, Jing M. Modulation of insulin signaling in human skeletal muscle in response to exercise. Exerc Sport Sci Rev. 2002;30:85-90 pubmed
    ..Recent discoveries in the molecular and cellular regulation of insulin-mediated glucose metabolism in skeletal muscle have provided a deeper understanding of how exercise modulates insulin action. ..
  12. Lafuse W, Alvarez G, Zwilling B. Role of MAP kinase activation in Nramp1 mRNA stability in RAW264.7 macrophages expressing Nramp1(Gly169). Cell Immunol. 2002;215:195-206 pubmed
    ..7-Nramp1(Gly169) cells than in RAW26.47-Nramp1(Asp169) cells. These results suggest that generation of oxidants by Nramp1 iron transport activates MAP kinase signaling cascades that result in stabilization of Nramp1 mRNA. ..
  13. Zhou X, Waite K, Pilarski R, Hampel H, Fernandez M, Bos C, et al. Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway. Am J Hum Genet. 2003;73:404-11 pubmed
    ..These data suggest that patients with BRRS and CS without PCR-detected intragenic PTEN mutations be offered clinical deletion analysis and promoter-mutation analysis, respectively. ..
  14. Song K, Cornelius S, Reiss M, Danielpour D. Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2. J Biol Chem. 2003;278:38342-51 pubmed
    ..In summary, our data suggest that IGF-I inhibits TGF-beta transcriptional responses through selective suppression of Smad3 activation via a PI3K/Akt-dependent pathway. ..
  15. Wang Y, Meng A, Zhou D. Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp Cell Res. 2004;298:188-96 pubmed
    ..These findings demonstrate that expression of the senescent phenotype can be uncoupled from cell cycle arrest in prematurely senescent cells induced by H2O2 and does not contribute to the maintenance of permanent cell cycle arrest. ..
  16. Al Shami R, Sorensen E, Ek Rylander B, Andersson G, Carson D, Farach Carson M. Phosphorylated osteopontin promotes migration of human choriocarcinoma cells via a p70 S6 kinase-dependent pathway. J Cell Biochem. 2005;94:1218-33 pubmed
    ..Because both OPN and TRAP are expressed in the uterus during early pregnancy, it is conceivable that extracellular phosphatases such as TRAP may modify OPN charge state and thus modulate cell migration. ..
  17. Connor K, Subbaram S, Regan K, Nelson K, Mazurkiewicz J, Bartholomew P, et al. Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem. 2005;280:16916-24 pubmed
  18. Habas A, Kharebava G, Szatmari E, Hetman M. NMDA neuroprotection against a phosphatidylinositol-3 kinase inhibitor, LY294002 by NR2B-mediated suppression of glycogen synthase kinase-3beta-induced apoptosis. J Neurochem. 2006;96:335-48 pubmed
    ..Hence, the activation of NR2B and the Ser9-independent inhibition of GSK3beta are two newly identified elements of the signaling network that mediates the pro-survival effects of NMDA. ..
  19. Bevan C, Porter D, Schumann C, Bryleva E, Hendershot T, Liu H, et al. The endocrine-disrupting compound, nonylphenol, inhibits neurotrophin-dependent neurite outgrowth. Endocrinology. 2006;147:4192-204 pubmed
  20. Wilkes M, Leof E. Transforming growth factor beta activation of c-Abl is independent of receptor internalization and regulated by phosphatidylinositol 3-kinase and PAK2 in mesenchymal cultures. J Biol Chem. 2006;281:27846-54 pubmed
  21. Yalcin A, Clem B, Makoni S, Clem A, Nelson K, Thornburg J, et al. Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling. Oncogene. 2010;29:139-49 pubmed publisher
    ..Taken together, these data indicate that the pooling of phosphocholine in cancer cells may be required to provide a ready supply of phosphatidic acid necessary for the feed-forward amplification of cancer survival signaling pathways. ..
  22. Sarkaria J, Tibbetts R, Busby E, Kennedy A, Hill D, Abraham R. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res. 1998;58:4375-82 pubmed
    ..These results identify wortmannin as an inhibitor of ATM activity and suggest that ATM and DNA-PK are relevant targets for the radiosensitizing effect of this drug in cancer cells. ..
  23. Takikawa Y, Miyoshi H, Rust C, Roberts P, Siegel R, Mandal P, et al. The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes. Gastroenterology. 2001;120:1810-7 pubmed
    ..The TCDC/PI 3-K survival signal blocks Fas-mediated apoptosis by preventing caspase 8 activation and Bid mitochondrial translocation. Potentiation of this survival pathway in cholestasis has the potential to attenuate liver injury. ..
  24. Nguyen H, Ramana C, Bayes J, Stark G. Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression. J Biol Chem. 2001;276:33361-8 pubmed
  25. Rumsey L, Teague R, Benedict S, Chan M. MIP-1alpha induces activation of phosphatidylinositol-3 kinase that associates with Pyk-2 and is necessary for B-cell migration. Exp Cell Res. 2001;268:77-83 pubmed
    ..Hence, PI3-K and Pyk-2 seem to be components of a signal transduction pathway induced by stimulation of B cells with MIP-1alpha, and this pathway may play a role in B-cell migration. ..
  26. Blagoveshchenskaya A, Thomas L, Feliciangeli S, Hung C, Thomas G. HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. Cell. 2002;111:853-66 pubmed
    ..These data provide new insights into the cellular basis of HIV-1 immunoevasion. ..
  27. Goehring A, Rivers D, Sprague G. Urmylation: a ubiquitin-like pathway that functions during invasive growth and budding in yeast. Mol Biol Cell. 2003;14:4329-41 pubmed
    ..Moreover, these five genes have a role in invasive growth and display genetic interactions with the TOR pathway. In summary, our results suggest the urmylation pathway is involved in nutrient sensing and budding. ..
  28. Slomiany B, Slomiany A. Platelet-activating factor mediates Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis. IUBMB Life. 2004;56:41-6 pubmed
    ..Our findings suggest that PAF, through the interference with PI3K-dependent cNOS activation, plays a critical role in influencing the extent of pathological consequences of H. pylori infection on the synthesis of gastric mucin. ..
  29. Afaq F, Saleem M, Aziz M, Mukhtar H. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin. Toxicol Appl Pharmacol. 2004;195:361-9 pubmed
    ..One might envision the use of chemopreventive agents such as oleandrin in an emollient or patch for chemoprevention or treatment of skin cancer. ..
  30. Chen X, Splinter P, Tietz P, Huang B, Billadeau D, Larusso N. Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42. J Biol Chem. 2004;279:31671-8 pubmed
    ..parvum invasion of target epithelia results from the ability of the organism to trigger host cell PI3K/frabin signaling to activate the Cdc42 pathway, resulting in host cell actin remodeling at the host cell-parasite interface. ..
  31. McCurdy C, Davidson R, Cartee G. Calorie restriction increases the ratio of phosphatidylinositol 3-kinase catalytic to regulatory subunits in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2005;288:E996-E1001 pubmed
    ..The increased ratio of PI 3-kinase catalytic to regulatory subunits favors enhanced insulin signaling, which likely contributes to greater Akt phosphorylation and improved insulin sensitivity associated with CR in skeletal muscle. ..
  32. Slomiany M, Rosenzweig S. Hypoxia-inducible factor-1-dependent and -independent regulation of insulin-like growth factor-1-stimulated vascular endothelial growth factor secretion. J Pharmacol Exp Ther. 2006;318:666-75 pubmed
    ..In conclusion, IGF-1 regulates VEGF expression and secretion via HIF-1-dependent and -independent pathways. ..
  33. Sengupta S, Kim K, Berk M, Oates R, Escobar P, Belinson J, et al. Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion. Oncogene. 2007;26:2894-901 pubmed
    ..LPA downregulates TIMP3, which may have targets other than metalloproteinases. Our in vivo metastasis mouse model is useful for studying the efficacy of therapeutic regimes of ovarian cancer. ..
  34. Knostman K, McCubrey J, Morrison C, Zhang Z, Capen C, Jhiang S. PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer. BMC Cancer. 2007;7:137 pubmed
    ..Further study is warranted to realize the application of NIS-mediated radioiodide ablation in breast cancer. ..
  35. Park E, Wilder E, Chipuk J, Lane M. Retinol decreases phosphatidylinositol 3-kinase activity in colon cancer cells. Mol Carcinog. 2008;47:264-74 pubmed
    ..Thus, a decrease in PI3K activity due to retinol treatment may confer the ability of retinol to inhibit ATRA-resistant colon cancer cell invasion. ..
  36. Banerjee S, Mehta S, Haque I, Sengupta K, Dhar K, Kambhampati S, et al. VEGF-A165 induces human aortic smooth muscle cell migration by activating neuropilin-1-VEGFR1-PI3K axis. Biochemistry. 2008;47:3345-51 pubmed publisher
  37. Parsa K, Butchar J, Rajaram M, Cremer T, Tridandapani S. The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk. Mol Immunol. 2008;45:3012-21 pubmed publisher
    ..Collectively, these data identify Syk and Erk as key players in the phagocytosis of Francisella...
  38. Sharma P, Chakraborty R, Wang L, Min B, Tremblay M, Kawahara T, et al. Redox regulation of interleukin-4 signaling. Immunity. 2008;29:551-64 pubmed publisher
  39. COTERO V, Routh V. Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose. Am J Physiol Endocrinol Metab. 2009;296:E1101-9 pubmed publisher
    ..That is, in the presence of insulin, glucose levels must decline further before GE neurons respond. Thus, the set point for detection of glucose deficit and initiation of compensatory mechanisms would be lowered. ..
  40. Sand J, Aziz M, Dreckschmidt N, Havighurst T, Kim K, Oberley T, et al. PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas. J Invest Dermatol. 2010;130:270-7 pubmed publisher
    ..The results indicate that PKCepsilon level dictates susceptibility, irrespective of genetic background, to UVR carcinogenesis. ..
  41. Wang H, Leavitt L, Ramaswamy R, Rapraeger A. Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation. J Biol Chem. 2010;285:13569-79 pubmed publisher
    ..We propose that syndecans engage the distal region of the beta4 cytoplasmic domain and bring it to the plasma membrane, where it can be acted upon by Src family kinases. ..
  42. Kirwan J, Del Aguila L, Hernandez J, Williamson D, O Gorman D, Lewis R, et al. Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle. J Appl Physiol (1985). 2000;88:797-803 pubmed
    ..60, P < 0.02). We conclude that regular exercise leads to greater insulin-stimulated IRS-1-associated PI3-kinase activation in human skeletal muscle, thus facilitating enhanced insulin-mediated glucose uptake...
  43. Alexander A, Carey H. Involvement of PI 3-kinase in IGF-I stimulation of jejunal Na+-K+-ATPase activity and nutrient absorption. Am J Physiol Gastrointest Liver Physiol. 2001;280:G222-8 pubmed
    ..The results suggest that the effect of IGF-I on jejunal ion and nutrient transport involves activation of PI 3-kinase and stimulation of Na+-K+-ATPase activity in enterocytes...
  44. Sautin Y, Crawford J, Svetlov S. Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line. Am J Physiol Cell Physiol. 2001;281:C2010-9 pubmed
    ..Cell protection by LPA involves activation of the mitogen-activated protein kinase Erk1/Erk2 cascade and PI 3-kinase-dependent phosphorylation of Akt. ..
  45. Yang C, Lin H, Chen C, Yang Y, Tseng P, Rangnekar V, et al. Bcl-xL mediates a survival mechanism independent of the phosphoinositide 3-kinase/Akt pathway in prostate cancer cells. J Biol Chem. 2003;278:25872-8 pubmed
  46. Poser S, Impey S, Xia Z, Storm D. Brain-derived neurotrophic factor protection of cortical neurons from serum withdrawal-induced apoptosis is inhibited by cAMP. J Neurosci. 2003;23:4420-7 pubmed
    ..This study indicates that cAMP may inhibit some forms of neurotrophin-mediated neuronal survival and suggests that a number of PI3-kinase-regulated processes in neurons may be inhibited by cAMP. ..
  47. Siddiqui I, Adhami V, Afaq F, Ahmad N, Mukhtar H. Modulation of phosphatidylinositol-3-kinase/protein kinase B- and mitogen-activated protein kinase-pathways by tea polyphenols in human prostate cancer cells. J Cell Biochem. 2004;91:232-42 pubmed
    ..We suggest that detailed studies in appropriate tumor model system are needed to establish the relevance of the cell culture work to in vivo models. ..
  48. Razandi M, Pedram A, Merchenthaler I, Greene G, Levin E. Plasma membrane estrogen receptors exist and functions as dimers. Mol Endocrinol. 2004;18:2854-65 pubmed
    ..In summary, endogenous membrane ERs exist as dimers, a structural requirement that supports rapid signal transduction and affects cell physiology. ..
  49. Xin M, Deng X. Nicotine inactivation of the proapoptotic function of Bax through phosphorylation. J Biol Chem. 2005;280:10781-9 pubmed
    ..Thus, nicotine-induced survival and chemoresistance of human lung cancer cells may occur in a novel mechanism involving activation of PI3K/AKT that directly phosphorylates and inactivates the proapoptotic function of Bax. ..
  50. Gillio Meina C, Hui Y, Lavoie H. Expression of CCAAT/enhancer binding proteins alpha and beta in the porcine ovary and regulation in primary cultures of granulosa cells. Biol Reprod. 2005;72:1194-204 pubmed
    ..The differential expression of specific CEBPA/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity. ..
  51. Shingleton A. Body-size regulation: combining genetics and physiology. Curr Biol. 2005;15:R825-7 pubmed
    ..New research has revealed that the activity of the insulin-signaling pathway in the prothoracic gland of Drosophila modulates ecdysone release and thereby influences both the duration and rate of larval growth. ..
  52. Slomiany M, Black L, Kibbey M, Day T, Rosenzweig S. IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma. Biochem Biophys Res Commun. 2006;342:851-8 pubmed
    ..These results demonstrate the presence of an IGF-1 regulated VEGF autocrine loop in HNSCC. ..
  53. Ganesan L, Joshi T, Fang H, Kutala V, Roda J, Trotta R, et al. FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways. Blood. 2006;108:718-25 pubmed
    ..In contrast, inhibition of Ras/Erk, but not PI3K, suppressed IL-1beta production in these cells. Together, these data demonstrate that SHIP regulates phagocytosis-associated events through the inhibition of PI3K and Ras/Erk pathways. ..
  54. Hsuan S, Klintworth H, Xia Z. Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways. J Neurosci. 2006;26:4481-91 pubmed
  55. Druse M, Gillespie R, Tajuddin N, Rich M. S100B-mediated protection against the pro-apoptotic effects of ethanol on fetal rhombencephalic neurons. Brain Res. 2007;1150:46-54 pubmed
    ..Although the MAPKK inhibitor PD98059 reduced the number of surviving neurons in S100B-treated cultures, S100B did not activate MAPKK. ..
  56. Shukla S, Gupta S. Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells. Cell Cycle. 2007;6:1102-14 pubmed
    ..This study provides an insight into the molecular mechanism of apigenin in modulating various tyrosine kinases and perturbs cell cycle progression, suggesting its future development and use as anticancer agent in humans. ..
  57. Shukla S, Shukla M, MacLennan G, Fu P, Gupta S. Deregulation of FOXO3A during prostate cancer progression. Int J Oncol. 2009;34:1613-20 pubmed
    ..Our findings demonstrate that tumor associated alterations and redistribution of FOXO3A are frequent events in the etiology of prostate cancer. ..
  58. Dong W, Albers J, Vuletic S. Phospholipid transfer protein reduces phosphorylation of tau in human neuronal cells. J Neurosci Res. 2009;87:3176-85 pubmed publisher
    ..Our study suggests that PLTP may be an important modulator of signal transduction pathways in human neurons. ..
  59. Pitt S, Chen H, Kunnimalaiyaan M. Phosphatidylinositol 3-kinase-Akt signaling in pulmonary carcinoid cells. J Am Coll Surg. 2009;209:82-8 pubmed publisher
    ..But the importance of PI3K-Akt signaling has not been explored in pulmonary carcinoids. In this study, our objective was to establish the role of the PI3K-Akt signal transduction pathway in pulmonary carcinoid cells...
  60. Sinsimer D, Fallows D, Peixoto B, Krahenbuhl J, Kaplan G, Manca C. Mycobacterium leprae actively modulates the cytokine response in naive human monocytes. Infect Immun. 2010;78:293-300 pubmed publisher
    ..leprae plays an active role to control the release of cytokines from monocytes by providing both positive and negative regulatory signals via multiple signaling pathways involving PI3K, NF-kappaB, and caspase-1...
  61. Sun C, Zubcevic J, Polson J, Potts J, Diez Freire C, Zhang Q, et al. Shift to an involvement of phosphatidylinositol 3-kinase in angiotensin II actions on nucleus tractus solitarii neurons of the spontaneously hypertensive rat. Circ Res. 2009;105:1248-55 pubmed publisher
  62. Troxell M, Levine J, Beadling C, Warrick A, Dunlap J, Presnell A, et al. High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast. Mod Pathol. 2010;23:27-37 pubmed publisher
    ..These findings indicate that approximately two-thirds of papillomas are driven by mutations in the PI3CA/AKT pathway. Some papillary carcinomas may arise from these lesions, but others may have different molecular origins. ..
  63. Lavan B, Kuhne M, Garner C, Anderson D, Reedijk M, Pawson T, et al. The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains. J Biol Chem. 1992;267:11631-6 pubmed
    ..These findings indicate that the Tyr(P) form of pp160 associates directly with PI3K in vivo. ..
  64. Hickey M, Tanner C, O Neill D, Morgan L, Dohm G, Houmard J. Insulin activation of phosphatidylinositol 3-kinase in human skeletal muscle in vivo. J Appl Physiol (1985). 1997;83:718-22 pubmed
  65. Niswender K, Gallis B, Blevins J, Corson M, Schwartz M, Baskin D. Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin. J Histochem Cytochem. 2003;51:275-83 pubmed
    ..We conclude that immunocytochemical PIP3 staining can detect changes in PI3K activation induced by insulin and leptin in cell culture and intact liver. ..
  66. Bois P, Grosveld G. FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts. EMBO J. 2003;22:1147-57 pubmed
    ..We conclude that in addition to the role of FoxO proteins in regulating cell cycle progress and apoptosis, FKHR controls the rate of myotube fusion during myogenic differentiation. ..
  67. Zhang S, Gozal D, Sachleben L, Rane M, Klein J, Gozal E. Hypoxia induces an autocrine-paracrine survival pathway via platelet-derived growth factor (PDGF)-B/PDGF-beta receptor/phosphatidylinositol 3-kinase/Akt signaling in RN46A neuronal cells. FASEB J. 2003;17:1709-11 pubmed
  68. Liu Y, Schiff M, Czymmek K, Tall czy Z, Levine B, Dinesh Kumar S. Autophagy regulates programmed cell death during the plant innate immune response. Cell. 2005;121:567-577 pubmed publisher
    ..Thus, the evolutionarily conserved autophagy pathway plays an essential role in plant innate immunity and negatively regulates PCD...
  69. Saleem M, Kaur S, Kweon M, Adhami V, Afaq F, Mukhtar H. Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway. Carcinogenesis. 2005;26:1956-64 pubmed
    ..Lupeol could be a potential agent against pancreatic cancer, however, further in-depth in vivo studies are warranted. ..
  70. Liu Y, Kvaratskhelia M, Hess S, Qu Y, Zou Y. Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B. J Biol Chem. 2005;280:32775-83 pubmed
  71. Ma Y, Yu W, Kong R, Trump D, Johnson C. Role of nongenomic activation of phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase 1/2 pathways in 1,25D3-mediated apoptosis in squamous cell carc. Cancer Res. 2006;66:8131-8 pubmed
    ..1,25D3 induces the activation of phosphatidylinositol 3-kinase/Akt, which suppresses 1,25D3-mediated apoptosis and prolongs the survival of SCC cells. ..
  72. Samant G, Sylvester P. gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. Cell Prolif. 2006;39:563-74 pubmed
  73. Mandal P, Hamilton T. Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophages. J Immunol. 2007;178:2542-8 pubmed
    ..These findings demonstrate that LY2/LY3 targets a novel TLR4-linked signaling pathway that selectively couples to the stabilization of FPR1 mRNA. ..
  74. Chen F, Wang C, Kim E, Harrison L. Hyperthermia in combination with oxidative stress induces autophagic cell death in HT-29 colon cancer cells. Cell Biol Int. 2008;32:715-23 pubmed publisher
    ..Thermal sensitization through modulation of cellular ROS may represent a novel approach to increase the efficacy of hyperthermia as an anticancer modality. ..
  75. Morris V, Punjabi A, Lagunoff M. Activation of Akt through gp130 receptor signaling is required for Kaposi's sarcoma-associated herpesvirus-induced lymphatic reprogramming of endothelial cells. J Virol. 2008;82:8771-9 pubmed publisher
  76. Lowry M, Lotinun S, Leontovich A, Zhang M, Maran A, Shogren K, et al. Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism. Endocrinology. 2008;149:5735-46 pubmed publisher
  77. Wang Y, Ji X, Pabbidi M, Samarel A, Lipsius S. Laminin acts via focal adhesion kinase/phosphatidylinositol-3' kinase/protein kinase B to down-regulate beta1-adrenergic receptor signalling in cat atrial myocytes. J Physiol. 2009;587:541-50 pubmed publisher
    ..These findings provide new insight into the cellular mechanisms by which the extracellular matrix can modulate atrial beta-AR signalling. ..
  78. Blagosklonny M. Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration. Cell Cycle. 2009;8:1883-7 pubmed
    ..How can growth inhibitors suppress senescence? May these aging-suppressants decelerate organismal aging? To answer these questions, we need to reconsider the meaning of aging. ..
  79. Stuart C, Howell M, Zhang Y, Yin D. Insulin-stimulated translocation of glucose transporter (GLUT) 12 parallels that of GLUT4 in normal muscle. J Clin Endocrinol Metab. 2009;94:3535-42 pubmed publisher
    ..Translocation of GLUT12 in cultured myoblasts was dependent on activation of PI3-K. GLUT12 may have evolutionarily preceded GLUT4 and now provides redundancy to the dominant GLUT4 system in muscle. ..
  80. Cholewa J, Nikolic D, Post S. Regulation of class A scavenger receptor-mediated cell adhesion and surface localization by PI3K: identification of a regulatory cytoplasmic motif. J Leukoc Biol. 2010;87:443-9 pubmed publisher
    ..Together, these results suggest a pathway in which SR-A binding to an immobilized ligand activates PI3K to recruit more receptor to the plasma membrane and enhances cell adhesion. ..
  81. Ha T, Lu C, Liu L, Hua F, Hu Y, Kelley J, et al. TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism. Am J Physiol Heart Circ Physiol. 2010;298:H984-91 pubmed publisher
    ..More significantly, Pam3 therapeutic treatment will have a potential clinical relevance. ..
  82. Yoo S, Deng Q, Cavnar P, Wu Y, Hahn K, Huttenlocher A. Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev Cell. 2010;18:226-36 pubmed publisher
    ..This work provides new insight into how cell signaling at the front and back of the cell is coordinated during polarized cell migration in intact tissues within a multicellular organism. ..
  83. Xu K, Riggs A, Ding Y, Yu F. Role of ErbB2 in Corneal Epithelial Wound Healing. Invest Ophthalmol Vis Sci. 2004;45:4277-83 pubmed
    ..ErbB2 serves as a critical component that couples erbB receptor tyrosine kinase to the migration machinery of corneal epithelial cells. ..
  84. Weng L, Smith W, Dahia P, Ziebold U, Gil E, Lees J, et al. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. Cancer Res. 1999;59:5808-14 pubmed
    ..Therefore, PTEN appears to suppress breast cancer growth through down-regulating PI3K signaling, which leads to the blockage of cell cycle progression and the induction of cell death, in a sequential manner. ..
  85. Chang S, Poser S, Xia Z. A novel role for serum response factor in neuronal survival. J Neurosci. 2004;24:2277-85 pubmed
    ..Our data provide a direct demonstration of a biological function of SRF in neurons and a novel downstream neuroprotective mechanism common to both ERK1/2 and PI3K pathways. ..
  86. Young M. Tumor-derived prostaglandin E2 and transforming growth factor-beta stimulate endothelial cell motility through inhibition of protein phosphatase-2A and involvement of PTEN and phosphatidylinositide 3-kinase. Angiogenesis. 2004;7:123-31 pubmed
    ..These studies showed that the increased endothelial cell motility that resulted from PGE2/TGFbeta inhibition of PP-2A was dependent on PI3K. ..
  87. Ruth M, Xu Y, Maxwell I, Ahn N, Norris D, Shellman Y. RhoC promotes human melanoma invasion in a PI3K/Akt-dependent pathway. J Invest Dermatol. 2006;126:862-8 pubmed
    ..We propose that RhoC promotes melanoma progression via separate mechanisms that regulate the PI3K/Akt pathway and the ROCK signaling pathway. ..
  88. Rojnuckarin P, Miyakawa Y, Fox N, Deou J, Daum G, Kaushansky K. The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes. J Biol Chem. 2001;276:41014-22 pubmed
    ..These data demonstrate a novel role of PI3K and PKCzeta in steady-state megakaryopoiesis. ..
  89. Shin S, Asano T, Yao Y, Zhang R, Claret F, Korc M, et al. Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism. Mol Cancer Res. 2009;7:745-754 pubmed publisher
    ..Collectively, our findings indicate that AP-1 has an important function in pancreatic cancer cells and provide evidence for a previously unknown Akt-mediated mechanism of c-Jun activation. ..
  90. Bilderback T, Lee F, Auersperg N, Rodland K. Phosphatidylinositol 3-kinase-dependent, MEK- independent proliferation in response to CaR activation. Am J Physiol Cell Physiol. 2002;283:C282-8 pubmed
    ..These results demonstrate that ERK activation cannot account for the full proliferative effect of elevated calcium in OSE cells and suggest the presence of an ERK-independent, PI3K-dependent component in the proliferative response. ..
  91. Yamaguchi T, Wallace D, Magenheimer B, Hempson S, Grantham J, Calvet J. Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype. J Biol Chem. 2004;279:40419-30 pubmed
    ..We conclude that disruption of calcium mobilization in cells that are normally growth-inhibited by cAMP can derepress the B-Raf/ERK pathway, thus converting these cells to a phenotype that is growth-stimulated by cAMP. ..
  92. Hu H, Chai Y, Wang L, Zhang J, Lee H, Kim S, et al. Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells. Mol Cancer Ther. 2009;8:2833-43 pubmed publisher
    ..The induction by PGG of caspase-independent programmed cell death in aggressive prostate cancer cell lines supports testing its merit as a potential drug candidate for therapy of caspase-resistant recurrent prostate cancer...